-- dump date 20120504_155708 -- class Genbank::misc_feature -- table misc_feature_note -- id note 653045000001 Helix-turn-helix domains; Region: HTH; cl00088 653045000002 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 653045000003 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 653045000004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045000005 non-specific DNA binding site [nucleotide binding]; other site 653045000006 salt bridge; other site 653045000007 sequence-specific DNA binding site [nucleotide binding]; other site 653045000008 amidase; Provisional; Region: PRK08137 653045000009 Amidase; Region: Amidase; cl11426 653045000010 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045000011 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 653045000012 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045000013 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045000014 salt bridge; other site 653045000015 non-specific DNA binding site [nucleotide binding]; other site 653045000016 sequence-specific DNA binding site [nucleotide binding]; other site 653045000017 Zeta toxin; Region: Zeta_toxin; pfam06414 653045000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000019 Zeta toxin; Region: Zeta_toxin; pfam06414 653045000020 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045000021 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000023 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045000024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045000025 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045000026 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045000027 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045000028 DNA binding residues [nucleotide binding] 653045000029 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045000030 DinB superfamily; Region: DinB_2; pfam12867 653045000031 Helix-turn-helix domains; Region: HTH; cl00088 653045000032 Predicted transcriptional regulator [Transcription]; Region: COG2378 653045000033 WYL domain; Region: WYL; cl14852 653045000034 Protein of unknown function DUF262; Region: DUF262; cl14890 653045000035 Carboxyl transferase domain; Region: Carboxyl_trans; pfam01039 653045000036 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045000037 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045000038 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045000039 dimerization interface [polypeptide binding]; other site 653045000040 putative DNA binding site [nucleotide binding]; other site 653045000041 putative Zn2+ binding site [ion binding]; other site 653045000042 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000043 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 653045000044 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000045 peptide synthase; Provisional; Region: PRK12467 653045000046 AMP-binding enzyme; Region: AMP-binding; cl15778 653045000047 AMP-binding enzyme; Region: AMP-binding; cl15778 653045000048 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045000049 AMP-binding enzyme; Region: AMP-binding; cl15778 653045000050 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045000051 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045000052 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045000053 AMP-binding enzyme; Region: AMP-binding; cl15778 653045000054 AMP-binding enzyme; Region: AMP-binding; cl15778 653045000055 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045000056 allantoate amidohydrolase; Reviewed; Region: PRK09290 653045000057 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 653045000058 active site 653045000059 metal binding site [ion binding]; metal-binding site 653045000060 dimer interface [polypeptide binding]; other site 653045000061 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 653045000062 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 653045000063 tartrate dehydrogenase; Provisional; Region: PRK08194 653045000064 aminotransferase; Validated; Region: PRK07777 653045000065 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045000066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045000067 homodimer interface [polypeptide binding]; other site 653045000068 catalytic residue [active] 653045000069 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 653045000070 substrate binding site [chemical binding]; other site 653045000071 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 653045000072 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 653045000073 substrate binding site [chemical binding]; other site 653045000074 ligand binding site [chemical binding]; other site 653045000075 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 653045000076 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 653045000077 active site 653045000078 catalytic residues [active] 653045000079 metal binding site [ion binding]; metal-binding site 653045000080 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045000081 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 653045000082 active site 653045000083 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045000084 non-specific DNA binding site [nucleotide binding]; other site 653045000085 salt bridge; other site 653045000086 sequence-specific DNA binding site [nucleotide binding]; other site 653045000087 NB-ARC domain; Region: NB-ARC; pfam00931 653045000088 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 653045000090 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000091 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045000092 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 653045000093 Fic/DOC family; Region: Fic; cl00960 653045000094 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045000095 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000096 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045000097 binding surface 653045000098 TPR motif; other site 653045000099 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000100 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045000101 binding surface 653045000102 TPR motif; other site 653045000103 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000104 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045000105 binding surface 653045000106 TPR motif; other site 653045000107 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000108 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045000110 binding surface 653045000111 TPR motif; other site 653045000112 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000113 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 653045000114 Transposase; Region: DDE_Tnp_ISL3; pfam01610 653045000115 Helix-turn-helix domains; Region: HTH; cl00088 653045000116 Transposase; Region: DDE_Tnp_ISL3; pfam01610 653045000117 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 653045000118 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 653045000119 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 653045000120 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 653045000121 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09729 653045000122 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 653045000123 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 653045000124 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000125 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045000126 Helix-turn-helix domains; Region: HTH; cl00088 653045000127 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045000128 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045000129 putative NAD(P) binding site [chemical binding]; other site 653045000130 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 653045000131 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 653045000132 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 653045000133 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 653045000134 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045000135 MULE transposase domain; Region: MULE; pfam10551 653045000136 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 653045000137 Integrase core domain; Region: rve; cl01316 653045000138 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 653045000139 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045000140 Walker A motif; other site 653045000141 ATP binding site [chemical binding]; other site 653045000142 Walker B motif; other site 653045000143 arginine finger; other site 653045000144 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 653045000145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045000146 active site 653045000147 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 653045000148 active site 653045000149 catalytic residues [active] 653045000150 DNA binding site [nucleotide binding] 653045000151 Int/Topo IB signature motif; other site 653045000152 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045000153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045000154 DNA binding residues [nucleotide binding] 653045000155 Protein of unknown function DUF262; Region: DUF262; cl14890 653045000156 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045000157 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045000158 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 653045000159 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045000160 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 653045000161 active site 653045000162 DNA binding site [nucleotide binding] 653045000163 Int/Topo IB signature motif; other site 653045000164 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045000165 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000166 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045000167 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045000168 DNA-binding site [nucleotide binding]; DNA binding site 653045000169 UTRA domain; Region: UTRA; cl01230 653045000170 Transcription factor WhiB; Region: Whib; pfam02467 653045000171 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 653045000172 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 653045000173 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045000174 nudix motif; other site 653045000175 Phage protein Gp37/Gp68; Region: Gp37_Gp68; cl15384 653045000176 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 653045000177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000178 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 653045000179 Helix-turn-helix domains; Region: HTH; cl00088 653045000180 putative transposase OrfB; Reviewed; Region: PHA02517 653045000181 HTH-like domain; Region: HTH_21; pfam13276 653045000182 Integrase core domain; Region: rve; cl01316 653045000183 Integrase core domain; Region: rve_3; cl15866 653045000184 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000185 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000186 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 653045000187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045000188 putative substrate translocation pore; other site 653045000189 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 653045000190 active site 653045000191 catalytic site [active] 653045000192 substrate binding site [chemical binding]; other site 653045000193 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045000194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045000195 active site 653045000196 phosphorylation site [posttranslational modification] 653045000197 intermolecular recognition site; other site 653045000198 dimerization interface [polypeptide binding]; other site 653045000199 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045000200 DNA binding residues [nucleotide binding] 653045000201 Histidine kinase; Region: HisKA_3; pfam07730 653045000202 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045000203 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045000204 CHAT domain; Region: CHAT; pfam12770 653045000205 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 653045000206 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 653045000207 Magnesium ion binding site [ion binding]; other site 653045000208 ParB-like nuclease domain; Region: ParBc; cl02129 653045000209 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000210 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 653045000211 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 653045000212 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 653045000213 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000214 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000215 Tetratricopeptide repeat; Region: TPR_10; pfam13374 653045000216 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 653045000217 putative peptidoglycan binding site; other site 653045000218 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 653045000219 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000220 Walker A motif; other site 653045000221 ATP binding site [chemical binding]; other site 653045000222 Walker B motif; other site 653045000223 SAF domain; Region: SAF; cl00555 653045000224 Replication-relaxation; Region: Replic_Relax; pfam13814 653045000225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045000226 S-adenosylmethionine binding site [chemical binding]; other site 653045000227 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 653045000228 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 653045000229 Ligand Binding Site [chemical binding]; other site 653045000230 Molecular Tunnel; other site 653045000231 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 653045000232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045000233 S-adenosylmethionine binding site [chemical binding]; other site 653045000234 NlpC/P60 family; Region: NLPC_P60; cl11438 653045000235 AAA-like domain; Region: AAA_10; pfam12846 653045000236 TcpE family; Region: TcpE; pfam12648 653045000237 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 653045000238 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 653045000239 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 653045000240 Domain of unknown function (DUF4379); Region: DUF4379; pfam14311 653045000241 Transposase; Region: DEDD_Tnp_IS110; pfam01548 653045000242 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 653045000243 Superfamily II helicase [General function prediction only]; Region: COG1204 653045000244 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045000245 ATP binding site [chemical binding]; other site 653045000246 putative Mg++ binding site [ion binding]; other site 653045000247 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000248 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 653045000249 Divergent AAA domain; Region: AAA_4; pfam04326 653045000250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000251 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045000253 putative transposase OrfB; Reviewed; Region: PHA02517 653045000254 HTH-like domain; Region: HTH_21; pfam13276 653045000255 Integrase core domain; Region: rve; cl01316 653045000256 Integrase core domain; Region: rve_3; cl15866 653045000257 Helix-turn-helix domains; Region: HTH; cl00088 653045000258 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000259 AAA domain; Region: AAA_33; pfam13671 653045000260 AAA ATPase domain; Region: AAA_15; pfam13175 653045000261 AAA ATPase domain; Region: AAA_15; pfam13175 653045000262 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 653045000263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000264 Walker B; other site 653045000265 D-loop; other site 653045000266 H-loop/switch region; other site 653045000267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045000268 ATP binding site [chemical binding]; other site 653045000269 putative Mg++ binding site [ion binding]; other site 653045000270 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000271 Helicase associated domain; Region: HA; pfam03457 653045000272 Helicase associated domain; Region: HA; pfam03457 653045000273 Helicase associated domain; Region: HA; pfam03457 653045000274 Helicase associated domain; Region: HA; pfam03457 653045000275 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045000276 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 653045000277 active site 653045000278 Substrate binding site; other site 653045000279 Phage-related protein [Function unknown]; Region: COG5412 653045000280 Signal peptide peptidase; Region: Peptidase_A22B; cl01342 653045000281 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 653045000282 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 653045000283 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 653045000284 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 653045000285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045000286 cofactor binding site; other site 653045000287 DNA binding site [nucleotide binding] 653045000288 substrate interaction site [chemical binding]; other site 653045000289 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 653045000290 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 653045000291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045000292 cofactor binding site; other site 653045000293 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 653045000294 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 653045000295 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045000296 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045000297 active site 653045000298 DNA binding site [nucleotide binding] 653045000299 Int/Topo IB signature motif; other site 653045000300 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045000301 DNA-binding site [nucleotide binding]; DNA binding site 653045000302 RNA-binding motif; other site 653045000303 Helix-turn-helix domains; Region: HTH; cl00088 653045000304 DNA-binding site [nucleotide binding]; DNA binding site 653045000305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045000306 non-specific DNA binding site [nucleotide binding]; other site 653045000307 salt bridge; other site 653045000308 sequence-specific DNA binding site [nucleotide binding]; other site 653045000309 ERF superfamily; Region: ERF; pfam04404 653045000310 Flagellin N-methylase; Region: FliB; cl00497 653045000311 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 653045000312 active site 653045000313 catalytic site [active] 653045000314 substrate binding site [chemical binding]; other site 653045000315 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045000316 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 653045000317 Coenzyme A binding pocket [chemical binding]; other site 653045000318 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045000319 Protein of unknown function DUF262; Region: DUF262; cl14890 653045000320 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 653045000321 amidase catalytic site [active] 653045000322 Zn binding residues [ion binding]; other site 653045000323 substrate binding site [chemical binding]; other site 653045000324 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045000325 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 653045000326 nucleotide binding site/active site [active] 653045000327 HIT family signature motif; other site 653045000328 catalytic residue [active] 653045000329 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 653045000330 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 653045000331 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045000332 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 653045000333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045000334 catalytic residue [active] 653045000335 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 653045000336 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 653045000337 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045000338 FeS/SAM binding site; other site 653045000339 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 653045000340 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 653045000341 Probable Catalytic site; other site 653045000342 metal-binding site 653045000343 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045000344 nudix motif; other site 653045000345 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045000346 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13944 653045000347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045000348 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045000349 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045000350 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045000351 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045000352 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045000353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045000354 S-adenosylmethionine binding site [chemical binding]; other site 653045000355 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045000356 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 653045000357 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 653045000358 dimer interface [polypeptide binding]; other site 653045000359 active site 653045000360 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000361 NAD(P) binding site [chemical binding]; other site 653045000362 active site 653045000363 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045000364 classical (c) SDRs; Region: SDR_c; cd05233 653045000365 NAD(P) binding site [chemical binding]; other site 653045000366 active site 653045000367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045000368 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045000369 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045000370 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045000371 active site 653045000372 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 653045000373 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 653045000374 dimer interface [polypeptide binding]; other site 653045000375 active site 653045000376 CoA binding pocket [chemical binding]; other site 653045000377 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 653045000378 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 653045000379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045000380 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045000381 active site 653045000382 Int/Topo IB signature motif; other site 653045000383 DNA binding site [nucleotide binding] 653045000384 Recombination endonuclease VII; Region: Endonuclease_7; pfam02945 653045000385 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 653045000386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045000387 Coenzyme A binding pocket [chemical binding]; other site 653045000388 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 653045000389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045000390 Walker A motif; other site 653045000391 ATP binding site [chemical binding]; other site 653045000392 Walker B motif; other site 653045000393 arginine finger; other site 653045000394 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 653045000395 DnaA box-binding interface [nucleotide binding]; other site 653045000396 DNA polymerase III subunit beta; Validated; Region: PRK07761 653045000397 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 653045000398 putative DNA binding surface [nucleotide binding]; other site 653045000399 dimer interface [polypeptide binding]; other site 653045000400 beta-clamp/clamp loader binding surface; other site 653045000401 beta-clamp/translesion DNA polymerase binding surface; other site 653045000402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000403 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 653045000404 recombination protein F; Reviewed; Region: recF; PRK00064 653045000405 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 653045000406 Walker A/P-loop; other site 653045000407 ATP binding site [chemical binding]; other site 653045000408 Q-loop/lid; other site 653045000409 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000410 ABC transporter signature motif; other site 653045000411 Walker B; other site 653045000412 D-loop; other site 653045000413 H-loop/switch region; other site 653045000414 Protein of unknown function (DUF721); Region: DUF721; cl02324 653045000415 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 653045000416 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 653045000417 anchoring element; other site 653045000418 dimer interface [polypeptide binding]; other site 653045000419 ATP binding site [chemical binding]; other site 653045000420 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 653045000421 active site 653045000422 putative metal-binding site [ion binding]; other site 653045000423 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 653045000424 DNA gyrase subunit A; Validated; Region: PRK05560 653045000425 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 653045000426 CAP-like domain; other site 653045000427 active site 653045000428 primary dimer interface [polypeptide binding]; other site 653045000429 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 653045000430 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 653045000431 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 653045000432 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 653045000433 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 653045000434 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 653045000435 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 653045000436 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045000437 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045000438 active site 653045000439 ATP binding site [chemical binding]; other site 653045000440 substrate binding site [chemical binding]; other site 653045000441 activation loop (A-loop); other site 653045000442 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 653045000443 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 653045000444 Response regulator receiver domain; Region: Response_reg; pfam00072 653045000445 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045000446 active site 653045000447 phosphorylation site [posttranslational modification] 653045000448 intermolecular recognition site; other site 653045000449 dimerization interface [polypeptide binding]; other site 653045000450 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 653045000451 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 653045000452 active site 653045000453 Rhomboid family; Region: Rhomboid; cl11446 653045000454 Uncharacterized protein family (UPF0233); Region: UPF0233; cl11506 653045000455 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 653045000456 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 653045000457 active site 653045000458 catalytic site [active] 653045000459 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 653045000460 Glutamine amidotransferase class-I; Region: GATase; pfam00117 653045000461 glutamine binding [chemical binding]; other site 653045000462 catalytic triad [active] 653045000463 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 653045000464 active site 653045000465 catalytic site [active] 653045000466 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 653045000467 active site 653045000468 catalytic site [active] 653045000469 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045000470 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045000471 active site 653045000472 ATP binding site [chemical binding]; other site 653045000473 substrate binding site [chemical binding]; other site 653045000474 activation loop (A-loop); other site 653045000475 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 653045000476 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 653045000477 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 653045000478 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045000479 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 653045000480 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 653045000481 Protein phosphatase 2C; Region: PP2C; pfam00481 653045000482 active site 653045000483 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045000484 phosphopeptide binding site; other site 653045000485 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 653045000486 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045000487 phosphopeptide binding site; other site 653045000488 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045000489 Helix-turn-helix domains; Region: HTH; cl00088 653045000490 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 653045000491 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 653045000492 active site residue [active] 653045000493 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045000494 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 653045000495 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 653045000496 FAD binding pocket [chemical binding]; other site 653045000497 FAD binding motif [chemical binding]; other site 653045000498 phosphate binding motif [ion binding]; other site 653045000499 beta-alpha-beta structure motif; other site 653045000500 NAD(p) ribose binding residues [chemical binding]; other site 653045000501 NAD binding pocket [chemical binding]; other site 653045000502 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 653045000503 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045000504 catalytic loop [active] 653045000505 iron binding site [ion binding]; other site 653045000506 Domain of unknown function DUF59; Region: DUF59; cl00941 653045000507 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 653045000508 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 653045000509 Phenylacetic acid degradation B; Region: PaaB; cl01371 653045000510 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 653045000511 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 653045000512 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 653045000513 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 653045000514 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 653045000515 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 653045000516 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045000517 NAD(P) binding site [chemical binding]; other site 653045000518 catalytic residues [active] 653045000519 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 653045000520 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000521 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045000522 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045000523 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045000524 Helix-turn-helix domains; Region: HTH; cl00088 653045000525 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045000526 Helix-turn-helix domains; Region: HTH; cl00088 653045000527 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 653045000528 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 653045000529 tetramer interface [polypeptide binding]; other site 653045000530 TPP-binding site [chemical binding]; other site 653045000531 heterodimer interface [polypeptide binding]; other site 653045000532 phosphorylation loop region [posttranslational modification] 653045000533 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 653045000534 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 653045000535 alpha subunit interface [polypeptide binding]; other site 653045000536 TPP binding site [chemical binding]; other site 653045000537 heterodimer interface [polypeptide binding]; other site 653045000538 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 653045000539 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 653045000540 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 653045000541 E3 interaction surface; other site 653045000542 lipoyl attachment site [posttranslational modification]; other site 653045000543 e3 binding domain; Region: E3_binding; pfam02817 653045000544 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 653045000545 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045000546 active site 653045000547 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 653045000548 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 653045000549 dimer interface [polypeptide binding]; other site 653045000550 putative functional site; other site 653045000551 putative MPT binding site; other site 653045000552 Ion channel; Region: Ion_trans_2; cl11596 653045000553 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 653045000554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000555 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 653045000556 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 653045000557 NAD(P) binding site [chemical binding]; other site 653045000558 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 653045000559 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045000560 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045000561 active site 653045000562 ATP binding site [chemical binding]; other site 653045000563 substrate binding site [chemical binding]; other site 653045000564 activation loop (A-loop); other site 653045000565 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 653045000566 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045000567 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045000568 active site 653045000569 ATP binding site [chemical binding]; other site 653045000570 substrate binding site [chemical binding]; other site 653045000571 activation loop (A-loop); other site 653045000572 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045000573 Phosphotransferase enzyme family; Region: APH; pfam01636 653045000574 active site 653045000575 substrate binding site [chemical binding]; other site 653045000576 ATP binding site [chemical binding]; other site 653045000577 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045000578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045000579 active site 653045000580 phosphorylation site [posttranslational modification] 653045000581 intermolecular recognition site; other site 653045000582 dimerization interface [polypeptide binding]; other site 653045000583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045000584 DNA binding residues [nucleotide binding] 653045000585 dimerization interface [polypeptide binding]; other site 653045000586 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 653045000587 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 653045000588 TPP-binding site [chemical binding]; other site 653045000589 tetramer interface [polypeptide binding]; other site 653045000590 heterodimer interface [polypeptide binding]; other site 653045000591 phosphorylation loop region [posttranslational modification] 653045000592 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 653045000593 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 653045000594 alpha subunit interface [polypeptide binding]; other site 653045000595 TPP binding site [chemical binding]; other site 653045000596 heterodimer interface [polypeptide binding]; other site 653045000597 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 653045000598 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 653045000599 E3 interaction surface; other site 653045000600 lipoyl attachment site [posttranslational modification]; other site 653045000601 e3 binding domain; Region: E3_binding; pfam02817 653045000602 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 653045000603 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 653045000604 Helix-turn-helix domains; Region: HTH; cl00088 653045000605 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 653045000606 FCD domain; Region: FCD; cl11656 653045000607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045000608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045000609 putative substrate translocation pore; other site 653045000610 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 653045000611 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045000612 SCP-2 sterol transfer family; Region: SCP2; cl01225 653045000613 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 653045000614 TlpA-like family, DipZ-like subfamily; composed uncharacterized proteins containing a TlpA-like TRX domain. Some members show domain architectures similar to that of E. coli DipZ protein (also known as DsbD). The only eukaryotic members of the TlpA...; Region: TlpA_like_DipZ_like; cd03012 653045000615 catalytic residues [active] 653045000616 NHL repeat; Region: NHL; pfam01436 653045000617 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045000618 Helix-turn-helix domains; Region: HTH; cl00088 653045000619 DNA binding site [nucleotide binding] 653045000620 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045000621 M18 Peptidase Aspartyl aminopeptidase; Region: M18_DAP; cd05658 653045000622 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 653045000623 active site 653045000624 metal binding site [ion binding]; metal-binding site 653045000625 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 653045000626 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 653045000627 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 653045000628 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 653045000629 FAD binding site [chemical binding]; other site 653045000630 substrate binding site [chemical binding]; other site 653045000631 catalytic residues [active] 653045000632 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 653045000633 Pirin-related protein [General function prediction only]; Region: COG1741 653045000634 Cupin domain; Region: Cupin_2; cl09118 653045000635 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 653045000636 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045000637 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 653045000638 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 653045000639 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 653045000640 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 653045000641 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 653045000642 GAF domain; Region: GAF; cl15785 653045000643 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045000644 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045000645 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 653045000646 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 653045000647 dimer interface [polypeptide binding]; other site 653045000648 anticodon binding site; other site 653045000649 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 653045000650 homodimer interface [polypeptide binding]; other site 653045000651 motif 1; other site 653045000652 active site 653045000653 motif 2; other site 653045000654 GAD domain; Region: GAD; pfam02938 653045000655 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 653045000656 active site 653045000657 motif 3; other site 653045000658 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 653045000659 putative active site [active] 653045000660 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 653045000661 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 653045000662 active site 653045000663 HIGH motif; other site 653045000664 KMSKS motif; other site 653045000665 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 653045000666 tRNA binding surface [nucleotide binding]; other site 653045000667 anticodon binding site; other site 653045000668 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 653045000669 metal ion-dependent adhesion site (MIDAS); other site 653045000670 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 653045000671 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 653045000672 nucleotide binding site [chemical binding]; other site 653045000673 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045000674 Helix-turn-helix domains; Region: HTH; cl00088 653045000675 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045000676 dimerization interface [polypeptide binding]; other site 653045000677 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 653045000678 putative catalytic site [active] 653045000679 putative metal binding site [ion binding]; other site 653045000680 putative phosphate binding site [ion binding]; other site 653045000681 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 653045000682 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 653045000683 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 653045000684 active site 653045000685 DNA binding site [nucleotide binding] 653045000686 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 653045000687 DNA binding site [nucleotide binding] 653045000688 sensory histidine kinase DcuS; Provisional; Region: PRK11086 653045000689 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045000690 GAF domain; Region: GAF; cl15785 653045000691 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045000692 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045000693 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045000694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045000695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045000696 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045000697 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045000698 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 653045000699 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000700 G2 box; other site 653045000701 Switch I region; other site 653045000702 G3 box; other site 653045000703 Switch II region; other site 653045000704 G4 box; other site 653045000705 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045000706 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045000707 non-specific DNA binding site [nucleotide binding]; other site 653045000708 salt bridge; other site 653045000709 sequence-specific DNA binding site [nucleotide binding]; other site 653045000710 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 653045000711 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 653045000712 nudix motif; other site 653045000713 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000714 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000715 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 653045000716 putative trimer interface [polypeptide binding]; other site 653045000717 putative CoA binding site [chemical binding]; other site 653045000718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045000719 Helix-turn-helix domains; Region: HTH; cl00088 653045000720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045000721 dimerization interface [polypeptide binding]; other site 653045000722 Helix-turn-helix domains; Region: HTH; cl00088 653045000723 putative transposase OrfB; Reviewed; Region: PHA02517 653045000724 HTH-like domain; Region: HTH_21; pfam13276 653045000725 Integrase core domain; Region: rve; cl01316 653045000726 Integrase core domain; Region: rve_3; cl15866 653045000727 Domain of unknown function (DUF305); Region: DUF305; cl15795 653045000728 Protein of unknown function (DUF3105); Region: DUF3105; pfam11303 653045000729 AMP-binding enzyme; Region: AMP-binding; cl15778 653045000730 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045000731 NAD(P) binding site [chemical binding]; other site 653045000732 catalytic residues [active] 653045000733 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045000734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045000735 active site 653045000736 phosphorylation site [posttranslational modification] 653045000737 intermolecular recognition site; other site 653045000738 dimerization interface [polypeptide binding]; other site 653045000739 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045000740 DNA binding site [nucleotide binding] 653045000741 Cellulose binding domain; Region: CBM_2; cl02709 653045000742 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 653045000743 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 653045000744 inhibitor site; inhibition site 653045000745 active site 653045000746 dimer interface [polypeptide binding]; other site 653045000747 catalytic residue [active] 653045000748 Proline racemase; Region: Pro_racemase; pfam05544 653045000749 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 653045000750 FAD dependent oxidoreductase; Region: DAO; pfam01266 653045000751 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 653045000752 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 653045000753 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000754 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 653045000755 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 653045000756 DNA binding residues [nucleotide binding] 653045000757 TOBE domain; Region: TOBE_2; cl01440 653045000758 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 653045000759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045000760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045000761 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 653045000762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000763 Walker A/P-loop; other site 653045000764 ATP binding site [chemical binding]; other site 653045000765 Q-loop/lid; other site 653045000766 ABC transporter signature motif; other site 653045000767 Walker B; other site 653045000768 D-loop; other site 653045000769 H-loop/switch region; other site 653045000770 TOBE domain; Region: TOBE_2; cl01440 653045000771 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045000772 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045000773 non-specific DNA binding site [nucleotide binding]; other site 653045000774 salt bridge; other site 653045000775 sequence-specific DNA binding site [nucleotide binding]; other site 653045000776 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 653045000777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045000778 motif II; other site 653045000779 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 653045000780 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045000781 MMPL family; Region: MMPL; pfam03176 653045000782 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045000783 Histidine kinase; Region: HisKA_3; pfam07730 653045000784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045000785 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045000786 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045000787 active site 653045000788 phosphorylation site [posttranslational modification] 653045000789 intermolecular recognition site; other site 653045000790 dimerization interface [polypeptide binding]; other site 653045000791 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045000792 DNA binding residues [nucleotide binding] 653045000793 dimerization interface [polypeptide binding]; other site 653045000794 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 653045000795 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045000796 Helix-turn-helix domains; Region: HTH; cl00088 653045000797 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045000798 dimerization interface [polypeptide binding]; other site 653045000799 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 653045000800 active site 653045000801 8-oxo-dGMP binding site [chemical binding]; other site 653045000802 nudix motif; other site 653045000803 metal binding site [ion binding]; metal-binding site 653045000804 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 653045000805 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 653045000806 Domain of unknown function DUF21; Region: DUF21; pfam01595 653045000807 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 653045000808 Transporter associated domain; Region: CorC_HlyC; cl08393 653045000809 Domain of unknown function DUF21; Region: DUF21; pfam01595 653045000810 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 653045000811 Protein kinase domain; Region: Pkinase; pfam00069 653045000812 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045000813 active site 653045000814 ATP binding site [chemical binding]; other site 653045000815 substrate binding site [chemical binding]; other site 653045000816 activation loop (A-loop); other site 653045000817 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045000818 active site 653045000819 PQQ-like domain; Region: PQQ_2; pfam13360 653045000820 Trp docking motif [polypeptide binding]; other site 653045000821 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045000822 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045000823 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 653045000824 nudix motif; other site 653045000825 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045000826 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045000827 Predicted acetyltransferase [General function prediction only]; Region: COG3153 653045000828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045000829 Coenzyme A binding pocket [chemical binding]; other site 653045000830 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045000831 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045000832 active site 653045000833 phosphorylation site [posttranslational modification] 653045000834 intermolecular recognition site; other site 653045000835 dimerization interface [polypeptide binding]; other site 653045000836 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045000837 DNA binding residues [nucleotide binding] 653045000838 dimerization interface [polypeptide binding]; other site 653045000839 Histidine kinase; Region: HisKA_3; pfam07730 653045000840 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045000841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045000842 ATP binding site [chemical binding]; other site 653045000843 Mg2+ binding site [ion binding]; other site 653045000844 G-X-G motif; other site 653045000845 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045000846 Family description; Region: VCBS; pfam13517 653045000847 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045000848 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 653045000849 Flavoprotein; Region: Flavoprotein; cl08021 653045000850 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 653045000851 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 653045000852 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 653045000853 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 653045000854 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 653045000855 transmembrane helices; other site 653045000856 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 653045000857 Helix-turn-helix domains; Region: HTH; cl00088 653045000858 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045000859 Helix-turn-helix domains; Region: HTH; cl00088 653045000860 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045000861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045000862 putative substrate translocation pore; other site 653045000863 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045000864 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 653045000865 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045000866 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 653045000867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4315 653045000869 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045000870 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045000871 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045000872 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 653045000873 trimer interface [polypeptide binding]; other site 653045000874 active site 653045000875 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 653045000876 active site 653045000877 DDE superfamily endonuclease; Region: DDE_5; cl02413 653045000878 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 653045000879 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 653045000880 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045000881 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 653045000882 catalytic residues [active] 653045000883 catalytic nucleophile [active] 653045000884 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045000885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045000886 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045000887 active site 653045000888 metal binding site [ion binding]; metal-binding site 653045000889 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 653045000890 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045000891 putative active site [active] 653045000892 putative metal binding site [ion binding]; other site 653045000893 hypothetical protein; Provisional; Region: PRK06126 653045000894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045000895 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045000896 Helix-turn-helix domains; Region: HTH; cl00088 653045000897 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045000898 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 653045000899 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 653045000900 active site 653045000901 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000902 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045000903 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045000904 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045000905 DNA-binding site [nucleotide binding]; DNA binding site 653045000906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045000907 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 653045000908 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 653045000909 catalytic residues [active] 653045000910 catalytic nucleophile [active] 653045000911 Recombinase; Region: Recombinase; pfam07508 653045000912 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 653045000913 Yip1 domain; Region: Yip1; cl12048 653045000914 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045000915 GAF domain; Region: GAF; cl15785 653045000916 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045000917 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045000918 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045000919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045000920 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 653045000921 4Fe-4S binding domain; Region: Fer4; cl02805 653045000922 Cysteine-rich domain; Region: CCG; pfam02754 653045000923 Cysteine-rich domain; Region: CCG; pfam02754 653045000924 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 653045000925 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 653045000926 dimer interface [polypeptide binding]; other site 653045000927 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 653045000928 chaperone protein DnaJ; Provisional; Region: PRK14279 653045000929 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 653045000930 HSP70 interaction site [polypeptide binding]; other site 653045000931 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 653045000932 Zn binding sites [ion binding]; other site 653045000933 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 653045000934 dimer interface [polypeptide binding]; other site 653045000935 Helix-Turn-Helix DNA binding domain of HspR-like transcription regulators; Region: HTH_HspR-like; cd01279 653045000936 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045000937 DNA binding residues [nucleotide binding] 653045000938 putative dimer interface [polypeptide binding]; other site 653045000939 proline/glycine betaine transporter; Provisional; Region: PRK10642 653045000940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045000941 putative substrate translocation pore; other site 653045000942 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045000943 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 653045000944 Clp amino terminal domain; Region: Clp_N; pfam02861 653045000945 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045000946 Walker A motif; other site 653045000947 ATP binding site [chemical binding]; other site 653045000948 Walker B motif; other site 653045000949 arginine finger; other site 653045000950 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045000951 Walker A motif; other site 653045000952 ATP binding site [chemical binding]; other site 653045000953 Walker B motif; other site 653045000954 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 653045000955 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 653045000956 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045000957 aminotransferase; Validated; Region: PRK07777 653045000958 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045000959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045000960 homodimer interface [polypeptide binding]; other site 653045000961 catalytic residue [active] 653045000962 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045000963 Protein of unknown function DUF2617; Region: DUF2617; pfam10936 653045000964 spermidine synthase; Provisional; Region: PRK03612 653045000965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045000966 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045000967 hydrophobic ligand binding site; other site 653045000968 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 653045000969 active site 653045000970 catalytic residues [active] 653045000971 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 653045000972 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 653045000973 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045000974 active site 653045000975 intersubunit interface [polypeptide binding]; other site 653045000976 zinc binding site [ion binding]; other site 653045000977 Na+ binding site [ion binding]; other site 653045000978 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045000979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045000980 putative substrate translocation pore; other site 653045000981 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 653045000982 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 653045000983 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045000984 kynureninase; Region: kynureninase; TIGR01814 653045000985 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 653045000986 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045000987 Histidine kinase; Region: HisKA_3; pfam07730 653045000988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045000989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045000990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045000991 active site 653045000992 phosphorylation site [posttranslational modification] 653045000993 intermolecular recognition site; other site 653045000994 dimerization interface [polypeptide binding]; other site 653045000995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045000996 DNA binding residues [nucleotide binding] 653045000997 dimerization interface [polypeptide binding]; other site 653045000998 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045000999 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045001000 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045001001 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 653045001002 Walker A/P-loop; other site 653045001003 ATP binding site [chemical binding]; other site 653045001004 Q-loop/lid; other site 653045001005 ABC transporter signature motif; other site 653045001006 Walker B; other site 653045001007 D-loop; other site 653045001008 H-loop/switch region; other site 653045001009 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 653045001010 Predicted transcriptional regulators [Transcription]; Region: COG1510 653045001011 Helix-turn-helix domains; Region: HTH; cl00088 653045001012 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 653045001013 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 653045001014 GDP-binding site [chemical binding]; other site 653045001015 ACT binding site; other site 653045001016 IMP binding site; other site 653045001017 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045001018 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045001019 active site 653045001020 ATP binding site [chemical binding]; other site 653045001021 substrate binding site [chemical binding]; other site 653045001022 activation loop (A-loop); other site 653045001023 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 653045001024 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045001025 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045001026 active site 653045001027 ATP binding site [chemical binding]; other site 653045001028 substrate binding site [chemical binding]; other site 653045001029 activation loop (A-loop); other site 653045001030 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045001031 hypothetical protein; Provisional; Region: PRK06062 653045001032 inhibitor-cofactor binding pocket; inhibition site 653045001033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045001034 catalytic residue [active] 653045001035 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045001036 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045001037 DNA-binding site [nucleotide binding]; DNA binding site 653045001038 FCD domain; Region: FCD; cl11656 653045001039 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 653045001040 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 653045001041 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045001042 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 653045001043 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 653045001044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001045 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 653045001046 ATP binding site [chemical binding]; other site 653045001047 active site 653045001048 substrate binding site [chemical binding]; other site 653045001049 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045001050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045001051 active site 653045001052 phosphorylation site [posttranslational modification] 653045001053 intermolecular recognition site; other site 653045001054 dimerization interface [polypeptide binding]; other site 653045001055 Helix-turn-helix domains; Region: HTH; cl00088 653045001056 DNA binding residues [nucleotide binding] 653045001057 dimerization interface [polypeptide binding]; other site 653045001058 Lsr2; Region: Lsr2; pfam11774 653045001059 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 653045001060 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 653045001061 putative active site [active] 653045001062 catalytic triad [active] 653045001063 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 653045001064 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 653045001065 dimerization interface [polypeptide binding]; other site 653045001066 ATP binding site [chemical binding]; other site 653045001067 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 653045001068 dimerization interface [polypeptide binding]; other site 653045001069 ATP binding site [chemical binding]; other site 653045001070 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045001071 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045001072 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 653045001073 amidophosphoribosyltransferase; Provisional; Region: PRK07847 653045001074 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 653045001075 active site 653045001076 tetramer interface [polypeptide binding]; other site 653045001077 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 653045001078 active site 653045001079 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 653045001080 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 653045001081 dimerization interface [polypeptide binding]; other site 653045001082 putative ATP binding site [chemical binding]; other site 653045001083 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 653045001084 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 653045001085 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 653045001086 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 653045001087 NAD binding site [chemical binding]; other site 653045001088 Phe binding site; other site 653045001089 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 653045001090 DNA binding residues [nucleotide binding] 653045001091 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 653045001092 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045001093 ATP binding site [chemical binding]; other site 653045001094 putative Mg++ binding site [ion binding]; other site 653045001095 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045001096 nucleotide binding region [chemical binding]; other site 653045001097 ATP-binding site [chemical binding]; other site 653045001098 Helicase associated domain (HA2); Region: HA2; cl04503 653045001099 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 653045001100 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 653045001101 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 653045001102 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 653045001103 Protein of unknown function (DUF1152); Region: DUF1152; pfam06626 653045001104 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4034 653045001105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045001106 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045001107 putative substrate translocation pore; other site 653045001108 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045001109 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045001110 NAD(P) binding site [chemical binding]; other site 653045001111 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045001112 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045001113 type III secretion system protein SsaD; Provisional; Region: PRK15367 653045001114 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 653045001115 dimer interface [polypeptide binding]; other site 653045001116 active site 653045001117 ADP-ribose binding site [chemical binding]; other site 653045001118 nudix motif; other site 653045001119 metal binding site [ion binding]; metal-binding site 653045001120 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 653045001121 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045001122 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 653045001123 active site 653045001124 metal binding site [ion binding]; metal-binding site 653045001125 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 653045001126 helicase 45; Provisional; Region: PTZ00424 653045001127 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 653045001128 ATP binding site [chemical binding]; other site 653045001129 Mg++ binding site [ion binding]; other site 653045001130 motif III; other site 653045001131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045001132 nucleotide binding region [chemical binding]; other site 653045001133 ATP-binding site [chemical binding]; other site 653045001134 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045001135 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045001136 Peptidase family M23; Region: Peptidase_M23; pfam01551 653045001137 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045001138 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045001139 active site 653045001140 catalytic tetrad [active] 653045001141 NgoMIV restriction enzyme; Region: NgoMIV_restric; pfam09015 653045001142 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045001143 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045001144 non-specific DNA binding site [nucleotide binding]; other site 653045001145 salt bridge; other site 653045001146 sequence-specific DNA binding site [nucleotide binding]; other site 653045001147 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045001148 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 653045001149 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 653045001150 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 653045001151 cofactor binding site; other site 653045001152 DNA binding site [nucleotide binding] 653045001153 substrate interaction site [chemical binding]; other site 653045001154 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 653045001155 mismatch recognition site; other site 653045001156 additional DNA contacts [nucleotide binding]; other site 653045001157 active site 653045001158 zinc binding site [ion binding]; other site 653045001159 DNA intercalation site [nucleotide binding]; other site 653045001160 Restriction endonuclease NaeI; Region: NaeI; pfam09126 653045001161 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 653045001162 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045001163 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045001164 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045001165 DNA binding residues [nucleotide binding] 653045001166 EBNA-3B; Provisional; Region: PHA03378 653045001167 Protease prsW family; Region: PrsW-protease; cl15823 653045001168 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045001169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001170 hydroxyglutarate oxidase; Provisional; Region: PRK11728 653045001171 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 653045001172 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045001173 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001174 Predicted ATPase [General function prediction only]; Region: COG3903 653045001175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045001176 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 653045001177 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045001178 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045001179 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045001180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045001181 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045001182 Helix-turn-helix domains; Region: HTH; cl00088 653045001183 AAA-like domain; Region: AAA_10; pfam12846 653045001184 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045001185 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 653045001186 N-acetyl-D-glucosamine binding site [chemical binding]; other site 653045001187 catalytic residue [active] 653045001188 NlpC/P60 family; Region: NLPC_P60; cl11438 653045001189 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 653045001190 active site 653045001191 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 653045001192 FAD binding domain; Region: FAD_binding_4; pfam01565 653045001193 Berberine and berberine like; Region: BBE; pfam08031 653045001194 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 653045001195 putative homodimer interface [polypeptide binding]; other site 653045001196 putative homotetramer interface [polypeptide binding]; other site 653045001197 putative allosteric switch controlling residues; other site 653045001198 putative metal binding site [ion binding]; other site 653045001199 putative homodimer-homodimer interface [polypeptide binding]; other site 653045001200 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 653045001201 Phosphate transporter family; Region: PHO4; cl00396 653045001202 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 653045001203 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 653045001204 Walker A/P-loop; other site 653045001205 ATP binding site [chemical binding]; other site 653045001206 Q-loop/lid; other site 653045001207 ABC transporter signature motif; other site 653045001208 Walker B; other site 653045001209 D-loop; other site 653045001210 H-loop/switch region; other site 653045001211 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 653045001212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045001213 dimer interface [polypeptide binding]; other site 653045001214 conserved gate region; other site 653045001215 putative PBP binding loops; other site 653045001216 ABC-ATPase subunit interface; other site 653045001217 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 653045001218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045001219 dimer interface [polypeptide binding]; other site 653045001220 conserved gate region; other site 653045001221 putative PBP binding loops; other site 653045001222 ABC-ATPase subunit interface; other site 653045001223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045001224 NlpC/P60 family; Region: NLPC_P60; cl11438 653045001225 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 653045001226 putative ADP-ribose binding site [chemical binding]; other site 653045001227 putative active site [active] 653045001228 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 653045001229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 653045001230 active site 653045001231 phosphorylation site [posttranslational modification] 653045001232 intermolecular recognition site; other site 653045001233 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045001234 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 653045001235 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045001236 non-specific DNA binding site [nucleotide binding]; other site 653045001237 salt bridge; other site 653045001238 sequence-specific DNA binding site [nucleotide binding]; other site 653045001239 Helix-turn-helix domains; Region: HTH; cl00088 653045001240 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045001241 Carboxylesterase family; Region: COesterase; pfam00135 653045001242 substrate binding pocket [chemical binding]; other site 653045001243 catalytic triad [active] 653045001244 YCII-related domain; Region: YCII; cl00999 653045001245 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 653045001246 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045001247 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045001248 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045001249 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045001250 active site 653045001251 catalytic tetrad [active] 653045001252 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045001253 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045001254 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045001255 Helix-turn-helix domains; Region: HTH; cl00088 653045001256 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045001257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001258 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045001259 Walker A/P-loop; other site 653045001260 ATP binding site [chemical binding]; other site 653045001261 Q-loop/lid; other site 653045001262 ABC transporter signature motif; other site 653045001263 Walker B; other site 653045001264 D-loop; other site 653045001265 H-loop/switch region; other site 653045001266 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045001267 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045001268 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 653045001269 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 653045001270 DNA binding residues [nucleotide binding] 653045001271 dimer interface [polypeptide binding]; other site 653045001272 [2Fe-2S] cluster binding site [ion binding]; other site 653045001273 hypothetical protein; Provisional; Region: PRK01346 653045001274 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045001275 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 653045001276 putative active site [active] 653045001277 dimerization interface [polypeptide binding]; other site 653045001278 putative tRNAtyr binding site [nucleotide binding]; other site 653045001279 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 653045001280 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 653045001281 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 653045001282 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 653045001283 metal binding site 2 [ion binding]; metal-binding site 653045001284 putative DNA binding helix; other site 653045001285 metal binding site 1 [ion binding]; metal-binding site 653045001286 dimer interface [polypeptide binding]; other site 653045001287 structural Zn2+ binding site [ion binding]; other site 653045001288 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 653045001289 heme-binding site [chemical binding]; other site 653045001290 DsrE/DsrF-like family; Region: DrsE; cl00672 653045001291 Protein of unknown function (DUF1416); Region: DUF1416; pfam07210 653045001292 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 653045001293 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 653045001294 active site residue [active] 653045001295 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 653045001296 active site residue [active] 653045001297 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 653045001298 Ubiquitin-like proteins; Region: UBQ; cl00155 653045001299 charged pocket; other site 653045001300 hydrophobic patch; other site 653045001301 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045001302 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045001303 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001304 Walker A/P-loop; other site 653045001305 ATP binding site [chemical binding]; other site 653045001306 Q-loop/lid; other site 653045001307 ABC transporter signature motif; other site 653045001308 Walker B; other site 653045001309 D-loop; other site 653045001310 H-loop/switch region; other site 653045001311 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045001312 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 653045001313 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 653045001314 Walker A/P-loop; other site 653045001315 ATP binding site [chemical binding]; other site 653045001316 Q-loop/lid; other site 653045001317 ABC transporter signature motif; other site 653045001318 Walker B; other site 653045001319 D-loop; other site 653045001320 H-loop/switch region; other site 653045001321 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 653045001322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 653045001323 active site 653045001324 phosphorylation site [posttranslational modification] 653045001325 intermolecular recognition site; other site 653045001326 dimerization interface [polypeptide binding]; other site 653045001327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045001328 DNA binding site [nucleotide binding] 653045001329 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045001330 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045001331 DNA binding site [nucleotide binding] 653045001332 domain linker motif; other site 653045001333 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045001334 dimerization interface [polypeptide binding]; other site 653045001335 ligand binding site [chemical binding]; other site 653045001336 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045001337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045001338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045001339 active site 653045001340 phosphorylation site [posttranslational modification] 653045001341 intermolecular recognition site; other site 653045001342 dimerization interface [polypeptide binding]; other site 653045001343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045001344 DNA binding site [nucleotide binding] 653045001345 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045001346 dimerization interface [polypeptide binding]; other site 653045001347 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045001348 dimer interface [polypeptide binding]; other site 653045001349 phosphorylation site [posttranslational modification] 653045001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045001351 ATP binding site [chemical binding]; other site 653045001352 Mg2+ binding site [ion binding]; other site 653045001353 G-X-G motif; other site 653045001354 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 653045001355 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045001356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001357 Walker A/P-loop; other site 653045001358 ATP binding site [chemical binding]; other site 653045001359 Q-loop/lid; other site 653045001360 ABC transporter signature motif; other site 653045001361 Walker B; other site 653045001362 D-loop; other site 653045001363 H-loop/switch region; other site 653045001364 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045001365 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 653045001366 FtsX-like permease family; Region: FtsX; cl15850 653045001367 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045001368 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045001369 Walker A/P-loop; other site 653045001370 ATP binding site [chemical binding]; other site 653045001371 Q-loop/lid; other site 653045001372 ABC transporter signature motif; other site 653045001373 Walker B; other site 653045001374 D-loop; other site 653045001375 H-loop/switch region; other site 653045001376 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 653045001377 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 653045001378 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045001379 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045001380 active site 653045001381 phosphorylation site [posttranslational modification] 653045001382 intermolecular recognition site; other site 653045001383 dimerization interface [polypeptide binding]; other site 653045001384 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045001385 DNA binding site [nucleotide binding] 653045001386 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045001387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045001388 dimerization interface [polypeptide binding]; other site 653045001389 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 653045001390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045001391 ATP binding site [chemical binding]; other site 653045001392 Mg2+ binding site [ion binding]; other site 653045001393 G-X-G motif; other site 653045001394 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 653045001395 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 653045001396 RNA/DNA binding site [nucleotide binding]; other site 653045001397 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 653045001398 putative active site [active] 653045001399 putative FMN binding site [chemical binding]; other site 653045001400 putative substrate binding site [chemical binding]; other site 653045001401 putative catalytic residue [active] 653045001402 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13942 653045001403 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045001404 S-adenosylmethionine binding site [chemical binding]; other site 653045001405 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045001406 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045001407 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045001408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045001409 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 653045001410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001411 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 653045001412 Peptidase family M23; Region: Peptidase_M23; pfam01551 653045001413 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 653045001414 Helix-turn-helix domains; Region: HTH; cl00088 653045001415 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045001416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045001417 putative substrate translocation pore; other site 653045001418 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045001419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045001420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045001421 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 653045001422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045001423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045001424 dimer interface [polypeptide binding]; other site 653045001425 phosphorylation site [posttranslational modification] 653045001426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045001427 ATP binding site [chemical binding]; other site 653045001428 Mg2+ binding site [ion binding]; other site 653045001429 G-X-G motif; other site 653045001430 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045001431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045001432 active site 653045001433 phosphorylation site [posttranslational modification] 653045001434 intermolecular recognition site; other site 653045001435 dimerization interface [polypeptide binding]; other site 653045001436 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045001437 DNA binding site [nucleotide binding] 653045001438 LppP/LprE lipoprotein; Region: Lipoprotein_21; pfam14041 653045001439 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045001440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045001441 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045001442 DNA binding residues [nucleotide binding] 653045001443 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 653045001444 endonuclease III; Region: ENDO3c; smart00478 653045001445 minor groove reading motif; other site 653045001446 helix-hairpin-helix signature motif; other site 653045001447 substrate binding pocket [chemical binding]; other site 653045001448 active site 653045001449 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 653045001450 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 653045001451 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 653045001452 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 653045001453 DNA repair protein RadA; Provisional; Region: PRK11823 653045001454 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001455 Walker A motif; other site 653045001456 ATP binding site [chemical binding]; other site 653045001457 Walker B motif; other site 653045001458 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 653045001459 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 653045001460 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 653045001461 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045001462 Metal-binding active site; metal-binding site 653045001463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045001464 Helix-turn-helix domains; Region: HTH; cl00088 653045001465 Dehydratase family; Region: ILVD_EDD; cl00340 653045001466 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045001467 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045001468 active site 653045001469 ATP binding site [chemical binding]; other site 653045001470 substrate binding site [chemical binding]; other site 653045001471 activation loop (A-loop); other site 653045001472 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045001473 Trp docking motif [polypeptide binding]; other site 653045001474 active site 653045001475 PQQ-like domain; Region: PQQ_2; pfam13360 653045001476 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045001477 Uncharacterized protein with a bacterial SH3 domain homologue [Function unknown]; Region: COG4991 653045001478 Bacterial SH3 domain; Region: SH3_3; cl02551 653045001479 Sulfate transporter family; Region: Sulfate_transp; cl15842 653045001480 Sulfate transporter family; Region: Sulfate_transp; cl15842 653045001481 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 653045001482 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001483 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 653045001484 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 653045001485 active site 653045001486 HIGH motif; other site 653045001487 dimer interface [polypeptide binding]; other site 653045001488 KMSKS motif; other site 653045001489 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 653045001490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045001491 active site 653045001492 motif I; other site 653045001493 motif II; other site 653045001494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045001495 putative substrate translocation pore; other site 653045001496 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 653045001497 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 653045001498 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045001499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001500 NAD(P) binding site [chemical binding]; other site 653045001501 active site 653045001502 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987 653045001503 putative acyl-acceptor binding pocket; other site 653045001504 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 653045001505 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045001506 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045001507 DNA binding residues [nucleotide binding] 653045001508 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 653045001509 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045001510 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045001511 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 653045001512 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 653045001513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001514 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 653045001515 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 653045001516 tRNA; other site 653045001517 putative tRNA binding site [nucleotide binding]; other site 653045001518 putative NADP binding site [chemical binding]; other site 653045001519 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 653045001520 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 653045001521 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 653045001522 domain interfaces; other site 653045001523 active site 653045001524 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045001525 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 653045001526 active site 653045001527 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 653045001528 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 653045001529 dimer interface [polypeptide binding]; other site 653045001530 active site 653045001531 Schiff base residues; other site 653045001532 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001533 active site 653045001534 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 653045001535 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045001536 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045001537 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045001538 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 653045001539 arginine-tRNA ligase; Region: PLN02286 653045001540 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 653045001541 active site 653045001542 HIGH motif; other site 653045001543 KMSK motif region; other site 653045001544 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 653045001545 tRNA binding surface [nucleotide binding]; other site 653045001546 anticodon binding site; other site 653045001547 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 653045001548 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045001549 active site 653045001550 nucleotide binding site [chemical binding]; other site 653045001551 HIGH motif; other site 653045001552 KMSKS motif; other site 653045001553 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 653045001554 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 653045001555 hypothetical protein; Reviewed; Region: PRK09588 653045001556 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045001557 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 653045001558 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045001559 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045001560 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001561 NAD(P) binding site [chemical binding]; other site 653045001562 active site 653045001563 transcription termination factor Rho; Provisional; Region: PRK12678 653045001564 Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757 653045001565 DinB superfamily; Region: DinB_2; pfam12867 653045001566 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 653045001567 catalytic residues [active] 653045001568 catalytic nucleophile [active] 653045001569 Recombinase; Region: Recombinase; pfam07508 653045001570 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045001571 MULE transposase domain; Region: MULE; pfam10551 653045001572 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045001573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045001574 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045001575 DNA binding residues [nucleotide binding] 653045001576 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 653045001577 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045001578 inhibitor-cofactor binding pocket; inhibition site 653045001579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045001580 catalytic residue [active] 653045001581 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045001582 catalytic core [active] 653045001583 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 653045001584 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 653045001585 catalytic residues [active] 653045001586 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 653045001587 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 653045001588 ResB-like family; Region: ResB; pfam05140 653045001589 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 653045001590 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 653045001591 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 653045001592 UbiA prenyltransferase family; Region: UbiA; cl00337 653045001593 aromatic acid decarboxylase; Validated; Region: PRK05920 653045001594 Flavoprotein; Region: Flavoprotein; cl08021 653045001595 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045001596 Helix-turn-helix domains; Region: HTH; cl00088 653045001597 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 653045001598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045001599 FeS/SAM binding site; other site 653045001600 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 653045001601 Fe-S cluster binding site [ion binding]; other site 653045001602 active site 653045001603 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045001604 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 653045001605 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 653045001606 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 653045001607 Predicted esterase [General function prediction only]; Region: COG0627 653045001608 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045001609 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045001610 Helix-turn-helix domains; Region: HTH; cl00088 653045001611 Secretory lipase; Region: LIP; pfam03583 653045001612 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 653045001613 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045001614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045001615 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 653045001616 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045001617 DNA-binding site [nucleotide binding]; DNA binding site 653045001618 RNA-binding motif; other site 653045001619 NMT1-like family; Region: NMT1_2; cl15260 653045001620 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 653045001621 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045001622 active site 653045001623 ATP binding site [chemical binding]; other site 653045001624 substrate binding site [chemical binding]; other site 653045001625 activation loop (A-loop); other site 653045001626 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 653045001627 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045001628 FeS/SAM binding site; other site 653045001629 putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203 653045001630 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 653045001631 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045001632 S-adenosylmethionine binding site [chemical binding]; other site 653045001633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045001634 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 653045001635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001636 putative oxidoreductase; Provisional; Region: PRK11445 653045001637 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045001638 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045001639 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045001640 FOG: CBS domain [General function prediction only]; Region: COG0517 653045001641 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 653045001642 NlpC/P60 family; Region: NLPC_P60; cl11438 653045001643 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 653045001644 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 653045001645 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 653045001646 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16919 653045001647 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 653045001648 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 653045001649 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 653045001650 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 653045001651 putative dimer interface [polypeptide binding]; other site 653045001652 [2Fe-2S] cluster binding site [ion binding]; other site 653045001653 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 653045001654 SLBB domain; Region: SLBB; pfam10531 653045001655 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 653045001656 NADH dehydrogenase subunit G; Validated; Region: PRK07860 653045001657 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045001658 catalytic loop [active] 653045001659 iron binding site [ion binding]; other site 653045001660 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 653045001661 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045001662 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045001663 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 653045001664 NADH dehydrogenase; Region: NADHdh; cl00469 653045001665 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 653045001666 4Fe-4S binding domain; Region: Fer4; cl02805 653045001667 4Fe-4S binding domain; Region: Fer4; cl02805 653045001668 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 653045001669 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 653045001670 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 653045001671 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 653045001672 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 653045001673 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 653045001674 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 653045001675 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 653045001676 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 653045001677 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 653045001678 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 653045001679 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 653045001680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001681 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 653045001682 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 653045001683 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045001684 Walker A/P-loop; other site 653045001685 ATP binding site [chemical binding]; other site 653045001686 Q-loop/lid; other site 653045001687 ABC transporter signature motif; other site 653045001688 Walker B; other site 653045001689 D-loop; other site 653045001690 H-loop/switch region; other site 653045001691 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045001692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045001693 NMT1-like family; Region: NMT1_2; cl15260 653045001694 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 653045001695 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 653045001696 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 653045001697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045001698 DNA-binding site [nucleotide binding]; DNA binding site 653045001699 UTRA domain; Region: UTRA; cl01230 653045001700 PT repeat; Region: PT; pfam04886 653045001701 fumarylacetoacetase; Region: PLN02856 653045001702 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 653045001703 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045001704 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045001705 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001706 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 653045001707 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045001708 substrate binding pocket [chemical binding]; other site 653045001709 chain length determination region; other site 653045001710 substrate-Mg2+ binding site; other site 653045001711 catalytic residues [active] 653045001712 aspartate-rich region 1; other site 653045001713 active site lid residues [active] 653045001714 aspartate-rich region 2; other site 653045001715 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 653045001716 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045001717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001718 Walker A/P-loop; other site 653045001719 ATP binding site [chemical binding]; other site 653045001720 Q-loop/lid; other site 653045001721 ABC transporter signature motif; other site 653045001722 Walker B; other site 653045001723 D-loop; other site 653045001724 H-loop/switch region; other site 653045001725 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045001726 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 653045001727 active site 653045001728 metal binding site [ion binding]; metal-binding site 653045001729 Predicted permeases [General function prediction only]; Region: RarD; COG2962 653045001730 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045001731 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 653045001732 NADP binding site [chemical binding]; other site 653045001733 Amino acid permease; Region: AA_permease_2; pfam13520 653045001734 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 653045001735 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 653045001736 TPP-binding site [chemical binding]; other site 653045001737 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 653045001738 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 653045001739 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 653045001740 dimer interface [polypeptide binding]; other site 653045001741 PYR/PP interface [polypeptide binding]; other site 653045001742 TPP binding site [chemical binding]; other site 653045001743 substrate binding site [chemical binding]; other site 653045001744 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045001745 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045001746 active site 653045001747 phosphorylation site [posttranslational modification] 653045001748 intermolecular recognition site; other site 653045001749 dimerization interface [polypeptide binding]; other site 653045001750 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045001751 DNA binding residues [nucleotide binding] 653045001752 Putative sensor; Region: Sensor; pfam13796 653045001753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045001754 Histidine kinase; Region: HisKA_3; pfam07730 653045001755 Putative sensor; Region: Sensor; pfam13796 653045001756 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045001757 Histidine kinase; Region: HisKA_3; pfam07730 653045001758 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 653045001759 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 653045001760 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 653045001761 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16919 653045001762 NADH dehydrogenase; Region: NADHdh; cl00469 653045001763 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 653045001764 4Fe-4S binding domain; Region: Fer4; cl02805 653045001765 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 653045001766 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 653045001767 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 653045001768 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 653045001769 Peptidase family M48; Region: Peptidase_M48; cl12018 653045001770 hypothetical protein; Provisional; Region: PRK11770 653045001771 Domain of unknown function (DUF307); Region: DUF307; pfam03733 653045001772 Domain of unknown function (DUF307); Region: DUF307; pfam03733 653045001773 Protein of unknown function (DUF520); Region: DUF520; cl00723 653045001774 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 653045001775 active site 653045001776 catalytic residues [active] 653045001777 DNA binding site [nucleotide binding] 653045001778 Int/Topo IB signature motif; other site 653045001779 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045001780 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 653045001781 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 653045001782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045001783 cofactor binding site; other site 653045001784 DNA binding site [nucleotide binding] 653045001785 substrate interaction site [chemical binding]; other site 653045001786 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045001787 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045001788 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045001789 DNA-binding site [nucleotide binding]; DNA binding site 653045001790 UTRA domain; Region: UTRA; cl01230 653045001791 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045001792 S-adenosylmethionine binding site [chemical binding]; other site 653045001793 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 653045001794 DNA binding residues [nucleotide binding] 653045001795 putative dimer interface [polypeptide binding]; other site 653045001796 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 653045001797 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 653045001798 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 653045001799 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 653045001800 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 653045001801 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 653045001802 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045001803 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 653045001804 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 653045001805 Protein of unknown function (DUF3574); Region: DUF3574; pfam12098 653045001806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045001807 NAD(P) binding site [chemical binding]; other site 653045001808 active site 653045001809 cytosine deaminase; Provisional; Region: PRK05985 653045001810 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 653045001811 active site 653045001812 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 653045001813 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 653045001814 active site 653045001815 catalytic site [active] 653045001816 SAV4209_like. Similar in sequence to the Streptomyces avermitilis SAV4209 protein, with a hot dog fold that is similar to those of (R)-specific enoyl-CoA hydratase, the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid...; Region: SAV4209_like; cd03453 653045001817 active site 653045001818 catalytic site [active] 653045001819 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 653045001820 FAD binding domain; Region: FAD_binding_4; pfam01565 653045001821 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 653045001822 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 653045001823 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045001824 active site 653045001825 aspartate aminotransferase; Provisional; Region: PRK05764 653045001826 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045001827 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045001828 homodimer interface [polypeptide binding]; other site 653045001829 catalytic residue [active] 653045001830 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 653045001831 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 653045001832 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 653045001833 putative homodimer interface [polypeptide binding]; other site 653045001834 KOW motif; Region: KOW; cl00354 653045001835 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 653045001836 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 653045001837 23S rRNA interface [nucleotide binding]; other site 653045001838 L7/L12 interface [polypeptide binding]; other site 653045001839 putative thiostrepton binding site; other site 653045001840 L25 interface [polypeptide binding]; other site 653045001841 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 653045001842 mRNA/rRNA interface [nucleotide binding]; other site 653045001843 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 653045001844 23S rRNA interface [nucleotide binding]; other site 653045001845 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 653045001846 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 653045001847 peripheral dimer interface [polypeptide binding]; other site 653045001848 core dimer interface [polypeptide binding]; other site 653045001849 L10 interface [polypeptide binding]; other site 653045001850 L11 interface [polypeptide binding]; other site 653045001851 putative EF-Tu interaction site [polypeptide binding]; other site 653045001852 putative EF-G interaction site [polypeptide binding]; other site 653045001853 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 653045001854 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 653045001855 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 653045001856 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 653045001857 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 653045001858 RPB10 interaction site [polypeptide binding]; other site 653045001859 RPB1 interaction site [polypeptide binding]; other site 653045001860 RPB11 interaction site [polypeptide binding]; other site 653045001861 RPB3 interaction site [polypeptide binding]; other site 653045001862 RPB12 interaction site [polypeptide binding]; other site 653045001863 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 653045001864 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 653045001865 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 653045001866 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 653045001867 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 653045001868 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 653045001869 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 653045001870 G-loop; other site 653045001871 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 653045001872 DNA binding site [nucleotide binding] 653045001873 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 653045001874 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 653045001875 S17 interaction site [polypeptide binding]; other site 653045001876 S8 interaction site; other site 653045001877 16S rRNA interaction site [nucleotide binding]; other site 653045001878 streptomycin interaction site [chemical binding]; other site 653045001879 23S rRNA interaction site [nucleotide binding]; other site 653045001880 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 653045001881 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 653045001882 elongation factor G; Reviewed; Region: PRK00007 653045001883 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 653045001884 G1 box; other site 653045001885 putative GEF interaction site [polypeptide binding]; other site 653045001886 GTP/Mg2+ binding site [chemical binding]; other site 653045001887 Switch I region; other site 653045001888 G2 box; other site 653045001889 G3 box; other site 653045001890 Switch II region; other site 653045001891 G4 box; other site 653045001892 G5 box; other site 653045001893 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 653045001894 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 653045001895 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 653045001896 elongation factor Tu; Reviewed; Region: PRK00049 653045001897 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 653045001898 G1 box; other site 653045001899 GEF interaction site [polypeptide binding]; other site 653045001900 GTP/Mg2+ binding site [chemical binding]; other site 653045001901 Switch I region; other site 653045001902 G2 box; other site 653045001903 G3 box; other site 653045001904 Switch II region; other site 653045001905 G4 box; other site 653045001906 G5 box; other site 653045001907 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 653045001908 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 653045001909 Antibiotic Binding Site [chemical binding]; other site 653045001910 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 653045001911 putative hydrophobic ligand binding site [chemical binding]; other site 653045001912 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 653045001913 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045001914 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 653045001915 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 653045001916 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 653045001917 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 653045001918 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 653045001919 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 653045001920 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 653045001921 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 653045001922 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 653045001923 putative translocon binding site; other site 653045001924 protein-rRNA interface [nucleotide binding]; other site 653045001925 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 653045001926 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 653045001927 G-X-X-G motif; other site 653045001928 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 653045001929 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 653045001930 23S rRNA interface [nucleotide binding]; other site 653045001931 5S rRNA interface [nucleotide binding]; other site 653045001932 putative antibiotic binding site [chemical binding]; other site 653045001933 L25 interface [polypeptide binding]; other site 653045001934 L27 interface [polypeptide binding]; other site 653045001935 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 653045001936 23S rRNA interface [nucleotide binding]; other site 653045001937 putative translocon interaction site; other site 653045001938 signal recognition particle (SRP54) interaction site; other site 653045001939 L23 interface [polypeptide binding]; other site 653045001940 trigger factor interaction site; other site 653045001941 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 653045001942 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 653045001943 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 653045001944 KOW motif; Region: KOW; cl00354 653045001945 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 653045001946 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 653045001947 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 653045001948 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 653045001949 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 653045001950 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 653045001951 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 653045001952 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 653045001953 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 653045001954 5S rRNA interface [nucleotide binding]; other site 653045001955 L27 interface [polypeptide binding]; other site 653045001956 L5 interface [polypeptide binding]; other site 653045001957 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 653045001958 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 653045001959 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 653045001960 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 653045001961 23S rRNA binding site [nucleotide binding]; other site 653045001962 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 653045001963 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 653045001964 SecY translocase; Region: SecY; pfam00344 653045001965 adenylate kinase; Reviewed; Region: adk; PRK00279 653045001966 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 653045001967 AMP-binding site [chemical binding]; other site 653045001968 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 653045001969 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 653045001970 active site 653045001971 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 653045001972 rRNA binding site [nucleotide binding]; other site 653045001973 predicted 30S ribosome binding site; other site 653045001974 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 653045001975 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 653045001976 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 653045001977 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 653045001978 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 653045001979 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 653045001980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 653045001981 RNA binding surface [nucleotide binding]; other site 653045001982 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 653045001983 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 653045001984 alphaNTD homodimer interface [polypeptide binding]; other site 653045001985 alphaNTD - beta interaction site [polypeptide binding]; other site 653045001986 alphaNTD - beta' interaction site [polypeptide binding]; other site 653045001987 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 653045001988 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 653045001989 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 653045001990 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 653045001991 dimerization interface 3.5A [polypeptide binding]; other site 653045001992 active site 653045001993 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 653045001994 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 653045001995 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 653045001996 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 653045001997 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045001998 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045001999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045002000 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045002001 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045002002 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045002003 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045002004 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 653045002005 putative ADP-binding pocket [chemical binding]; other site 653045002006 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 653045002007 23S rRNA interface [nucleotide binding]; other site 653045002008 L3 interface [polypeptide binding]; other site 653045002009 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 653045002010 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 653045002011 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 653045002012 active site 653045002013 substrate binding site [chemical binding]; other site 653045002014 metal binding site [ion binding]; metal-binding site 653045002015 Domain of unknown function (DUF389); Region: DUF389; cl00781 653045002016 pantothenate kinase; Provisional; Region: PRK05439 653045002017 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point in...; Region: PanK; cd02025 653045002018 ATP-binding site [chemical binding]; other site 653045002019 CoA-binding site [chemical binding]; other site 653045002020 Mg2+-binding site [ion binding]; other site 653045002021 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 653045002022 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 653045002023 glutaminase active site [active] 653045002024 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 653045002025 dimer interface [polypeptide binding]; other site 653045002026 active site 653045002027 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 653045002028 dimer interface [polypeptide binding]; other site 653045002029 active site 653045002030 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 653045002031 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 653045002032 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 653045002033 putative substrate binding site [chemical binding]; other site 653045002034 putative ATP binding site [chemical binding]; other site 653045002035 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 653045002036 alanine racemase; Reviewed; Region: alr; PRK00053 653045002037 active site 653045002038 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045002039 dimer interface [polypeptide binding]; other site 653045002040 substrate binding site [chemical binding]; other site 653045002041 catalytic residues [active] 653045002042 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045002043 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045002044 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045002045 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045002046 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045002047 Helix-turn-helix domains; Region: HTH; cl00088 653045002048 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 653045002049 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 653045002050 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 653045002051 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045002052 putative glycoprotease GCP; Region: bact_gcp; TIGR03723 653045002053 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 653045002054 Helix-turn-helix domains; Region: HTH; cl00088 653045002055 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045002056 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045002057 Putative catalytic domain of uncharacterized prokaryotic polysaccharide deacetylases similar to bacterial PuuE allantoinases; Region: CE4_PuuE_like; cd10979 653045002058 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 653045002059 putative active site [active] 653045002060 putative catalytic site [active] 653045002061 N-acetyltransferase; Region: Acetyltransf_2; cl00949 653045002062 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045002063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045002064 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045002065 hydroxycinnamoyl-CoA:shikimate/quinate hydroxycinnamoyltransferase; Region: PLN02663 653045002066 Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601 653045002067 Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601 653045002068 Predicted methyltransferase [General function prediction only]; Region: COG2520 653045002069 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045002070 S-adenosylmethionine binding site [chemical binding]; other site 653045002071 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 653045002072 NodB motif; other site 653045002073 active site 653045002074 catalytic site [active] 653045002075 metal binding site [ion binding]; metal-binding site 653045002076 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 653045002077 oligomerisation interface [polypeptide binding]; other site 653045002078 mobile loop; other site 653045002079 roof hairpin; other site 653045002080 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 653045002081 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 653045002082 ring oligomerisation interface [polypeptide binding]; other site 653045002083 ATP/Mg binding site [chemical binding]; other site 653045002084 stacking interactions; other site 653045002085 hinge regions; other site 653045002086 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 653045002087 classical (c) SDRs; Region: SDR_c; cd05233 653045002088 NAD(P) binding site [chemical binding]; other site 653045002089 active site 653045002090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 653045002091 MOSC domain; Region: MOSC; pfam03473 653045002092 Helix-turn-helix domains; Region: HTH; cl00088 653045002093 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045002094 putative dimerization interface [polypeptide binding]; other site 653045002095 Transcription factor WhiB; Region: Whib; pfam02467 653045002096 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045002097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045002098 active site 653045002099 phosphorylation site [posttranslational modification] 653045002100 intermolecular recognition site; other site 653045002101 dimerization interface [polypeptide binding]; other site 653045002102 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045002103 DNA binding residues [nucleotide binding] 653045002104 dimerization interface [polypeptide binding]; other site 653045002105 RNA polymerase sigma factor SigD; Reviewed; Region: PRK09648 653045002106 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045002107 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045002108 DNA binding residues [nucleotide binding] 653045002109 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 653045002110 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045002111 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 653045002112 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 653045002113 active site 653045002114 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 653045002115 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 653045002116 active site 653045002117 rod shape-determining protein MreB; Provisional; Region: PRK13927 653045002118 Cell division protein FtsA; Region: FtsA; cl11496 653045002119 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 653045002120 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 653045002121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002122 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 653045002123 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045002124 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045002125 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045002126 active site 653045002127 ATP binding site [chemical binding]; other site 653045002128 substrate binding site [chemical binding]; other site 653045002129 activation loop (A-loop); other site 653045002130 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045002131 ATP binding site [chemical binding]; other site 653045002132 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045002133 cyclohexanecarboxylate-CoA ligase; Reviewed; Region: PRK13295 653045002134 AMP-binding enzyme; Region: AMP-binding; cl15778 653045002135 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 653045002136 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 653045002137 FAD binding site [chemical binding]; other site 653045002138 substrate binding site [chemical binding]; other site 653045002139 catalytic base [active] 653045002140 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045002141 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045002142 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045002143 Putative cyclase; Region: Cyclase; cl00814 653045002144 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 653045002145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002146 NAD(P) binding site [chemical binding]; other site 653045002147 active site 653045002148 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045002149 active site 653045002150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045002151 active site 653045002152 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045002153 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045002154 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045002155 NAD(P) binding site [chemical binding]; other site 653045002156 catalytic residues [active] 653045002157 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 653045002158 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 653045002159 NAD binding site [chemical binding]; other site 653045002160 catalytic Zn binding site [ion binding]; other site 653045002161 substrate binding site [chemical binding]; other site 653045002162 structural Zn binding site [ion binding]; other site 653045002163 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 653045002164 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045002165 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045002166 conserved cys residue [active] 653045002167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045002168 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045002169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045002170 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045002171 putative substrate translocation pore; other site 653045002172 Flavin Reductases; Region: FlaRed; cl00801 653045002173 enoyl-CoA hydratase; Provisional; Region: PRK06688 653045002174 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045002175 substrate binding site [chemical binding]; other site 653045002176 oxyanion hole (OAH) forming residues; other site 653045002177 trimer interface [polypeptide binding]; other site 653045002178 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 653045002179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002180 CoA-ligase; Region: Ligase_CoA; cl02894 653045002181 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045002182 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 653045002183 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 653045002184 DUF35 OB-fold domain; Region: DUF35; pfam01796 653045002185 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 653045002186 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045002187 thiolase; Provisional; Region: PRK06158 653045002188 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 653045002189 active site 653045002190 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045002191 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045002192 Domain of unknown function (DUF385); Region: DUF385; cl04387 653045002193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045002194 Helix-turn-helix domains; Region: HTH; cl00088 653045002195 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045002196 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045002197 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045002198 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045002199 active site 653045002200 ATP binding site [chemical binding]; other site 653045002201 substrate binding site [chemical binding]; other site 653045002202 activation loop (A-loop); other site 653045002203 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045002204 PQQ-like domain; Region: PQQ_2; pfam13360 653045002205 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045002206 Trp docking motif [polypeptide binding]; other site 653045002207 active site 653045002208 PQQ-like domain; Region: PQQ_2; pfam13360 653045002209 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 653045002210 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045002211 substrate binding site [chemical binding]; other site 653045002212 oxyanion hole (OAH) forming residues; other site 653045002213 trimer interface [polypeptide binding]; other site 653045002214 DUF35 OB-fold domain; Region: DUF35; pfam01796 653045002215 lipid-transfer protein; Provisional; Region: PRK07855 653045002216 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 653045002217 active site 653045002218 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 653045002219 AMP-binding enzyme; Region: AMP-binding; cl15778 653045002220 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045002221 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045002222 NB-ARC domain; Region: NB-ARC; pfam00931 653045002223 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045002224 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045002225 TPR motif; other site 653045002226 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045002227 binding surface 653045002228 NB-ARC domain; Region: NB-ARC; pfam00931 653045002229 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045002230 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045002231 binding surface 653045002232 TPR motif; other site 653045002233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045002234 binding surface 653045002235 TPR motif; other site 653045002236 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045002237 TPR repeat; Region: TPR_11; pfam13414 653045002238 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045002239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045002240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045002241 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 653045002242 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045002243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002244 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045002245 NAD(P) binding site [chemical binding]; other site 653045002246 active site 653045002247 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 653045002248 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045002249 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 653045002250 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 653045002251 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 653045002252 active site 653045002253 putative substrate binding pocket [chemical binding]; other site 653045002254 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045002255 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045002256 classical (c) SDRs; Region: SDR_c; cd05233 653045002257 NAD(P) binding site [chemical binding]; other site 653045002258 active site 653045002259 Helix-turn-helix domains; Region: HTH; cl00088 653045002260 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045002261 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 653045002262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045002263 S-adenosylmethionine binding site [chemical binding]; other site 653045002264 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 653045002265 FO synthase; Reviewed; Region: fbiC; PRK09234 653045002266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045002267 FeS/SAM binding site; other site 653045002268 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045002269 FeS/SAM binding site; other site 653045002270 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045002271 Probable transposase; Region: OrfB_IS605; pfam01385 653045002272 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 653045002273 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 653045002274 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 653045002275 Sodium:solute symporter family; Region: SSF; cl00456 653045002276 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 653045002277 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045002278 classical (c) SDRs; Region: SDR_c; cd05233 653045002279 NAD(P) binding site [chemical binding]; other site 653045002280 active site 653045002281 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045002282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045002283 sequence-specific DNA binding site [nucleotide binding]; other site 653045002284 salt bridge; other site 653045002285 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 653045002286 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 653045002287 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045002288 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045002289 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 653045002290 metal ion-dependent adhesion site (MIDAS); other site 653045002291 Double zinc ribbon; Region: DZR; pfam12773 653045002292 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045002293 active site 653045002294 ATP binding site [chemical binding]; other site 653045002295 substrate binding site [chemical binding]; other site 653045002296 activation loop (A-loop); other site 653045002297 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045002298 binding surface 653045002299 TPR motif; other site 653045002300 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045002301 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 653045002302 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 653045002303 G1 box; other site 653045002304 putative GEF interaction site [polypeptide binding]; other site 653045002305 GTP/Mg2+ binding site [chemical binding]; other site 653045002306 Switch I region; other site 653045002307 G2 box; other site 653045002308 G3 box; other site 653045002309 Switch II region; other site 653045002310 G4 box; other site 653045002311 G5 box; other site 653045002312 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 653045002313 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 653045002314 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 653045002315 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 653045002316 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 653045002317 Helix-turn-helix domains; Region: HTH; cl00088 653045002318 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045002319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002320 NAD(P) binding site [chemical binding]; other site 653045002321 active site 653045002322 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 653045002323 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 653045002324 putative DNA binding site [nucleotide binding]; other site 653045002325 putative homodimer interface [polypeptide binding]; other site 653045002326 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 653045002327 nucleotide binding site [chemical binding]; other site 653045002328 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 653045002329 active site 653045002330 DNA binding site [nucleotide binding] 653045002331 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 653045002332 Leucine carboxyl methyltransferase; Region: LCM; cl01306 653045002333 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 653045002334 active site 653045002335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002336 3-hydroxyacyl-CoA dehydrogenase; Validated; Region: PRK06129 653045002337 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045002338 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 653045002339 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 653045002340 Helix-turn-helix domains; Region: HTH; cl00088 653045002341 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045002342 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045002343 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045002344 active site 653045002345 ATP binding site [chemical binding]; other site 653045002346 substrate binding site [chemical binding]; other site 653045002347 activation loop (A-loop); other site 653045002348 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045002349 GYD domain; Region: GYD; cl01743 653045002350 FG-GAP repeat; Region: FG-GAP; cl15299 653045002351 Family description; Region: VCBS; pfam13517 653045002352 Family description; Region: VCBS; pfam13517 653045002353 Family description; Region: VCBS; pfam13517 653045002354 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 653045002355 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 653045002356 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045002357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002358 NAD(P) binding site [chemical binding]; other site 653045002359 active site 653045002360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045002361 non-specific DNA binding site [nucleotide binding]; other site 653045002362 salt bridge; other site 653045002363 sequence-specific DNA binding site [nucleotide binding]; other site 653045002364 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 653045002365 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 653045002366 IucA / IucC family; Region: IucA_IucC; pfam04183 653045002367 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 653045002368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 653045002369 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 653045002370 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 653045002371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002372 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 653045002373 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 653045002374 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045002375 catalytic residue [active] 653045002376 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 653045002377 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 653045002378 FAD binding pocket [chemical binding]; other site 653045002379 FAD binding motif [chemical binding]; other site 653045002380 phosphate binding motif [ion binding]; other site 653045002381 NAD binding pocket [chemical binding]; other site 653045002382 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 653045002383 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 653045002384 intersubunit interface [polypeptide binding]; other site 653045002385 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 653045002386 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 653045002387 FMN-binding pocket [chemical binding]; other site 653045002388 flavin binding motif; other site 653045002389 phosphate binding motif [ion binding]; other site 653045002390 beta-alpha-beta structure motif; other site 653045002391 NAD binding pocket [chemical binding]; other site 653045002392 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045002393 catalytic loop [active] 653045002394 iron binding site [ion binding]; other site 653045002395 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 653045002396 iron-sulfur cluster [ion binding]; other site 653045002397 [2Fe-2S] cluster binding site [ion binding]; other site 653045002398 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045002399 hydrophobic ligand binding site; other site 653045002400 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 653045002401 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 653045002402 Helix-turn-helix domains; Region: HTH; cl00088 653045002403 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 653045002404 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045002405 Helix-turn-helix domains; Region: HTH; cl00088 653045002406 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045002407 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045002408 Transcriptional regulators [Transcription]; Region: MarR; COG1846 653045002409 Helix-turn-helix domains; Region: HTH; cl00088 653045002410 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 653045002411 putative active site [active] 653045002412 metal binding site [ion binding]; metal-binding site 653045002413 Protein of unknown function (DUF4243); Region: DUF4243; pfam14027 653045002414 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 653045002415 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 653045002416 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045002417 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045002418 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045002419 DNA binding residues [nucleotide binding] 653045002420 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045002421 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002422 NAD(P) binding site [chemical binding]; other site 653045002423 active site 653045002424 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045002425 Helix-turn-helix domains; Region: HTH; cl00088 653045002426 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045002427 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 653045002428 putative substrate binding site [chemical binding]; other site 653045002429 putative ATP binding site [chemical binding]; other site 653045002430 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 653045002431 active site 653045002432 phosphorylation site [posttranslational modification] 653045002433 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 653045002434 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 653045002435 active site 653045002436 P-loop; other site 653045002437 phosphorylation site [posttranslational modification] 653045002438 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 653045002439 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 653045002440 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 653045002441 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 653045002442 cleavage site 653045002443 AMP-binding enzyme; Region: AMP-binding; cl15778 653045002444 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 653045002445 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 653045002446 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 653045002447 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 653045002448 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 653045002449 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 653045002450 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 653045002451 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 653045002452 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 653045002453 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 653045002454 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 653045002455 active site 653045002456 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 653045002457 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 653045002458 active site 653045002459 tetramer interface; other site 653045002460 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 653045002461 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 653045002462 dimer interface [polypeptide binding]; other site 653045002463 putative functional site; other site 653045002464 putative MPT binding site; other site 653045002465 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 653045002466 trimer interface [polypeptide binding]; other site 653045002467 dimer interface [polypeptide binding]; other site 653045002468 putative active site [active] 653045002469 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 653045002470 MPT binding site; other site 653045002471 trimer interface [polypeptide binding]; other site 653045002472 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045002473 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 653045002474 Ferritin-like domain; Region: Ferritin; pfam00210 653045002475 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 653045002476 dimerization interface [polypeptide binding]; other site 653045002477 DPS ferroxidase diiron center [ion binding]; other site 653045002478 ion pore; other site 653045002479 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045002480 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 653045002481 putative active site [active] 653045002482 putative DNA binding site [nucleotide binding]; other site 653045002483 putative catalytic site [active] 653045002484 putative phosphate binding site [ion binding]; other site 653045002485 metal binding site A [ion binding]; metal-binding site 653045002486 putative AP binding site [nucleotide binding]; other site 653045002487 putative metal binding site B [ion binding]; other site 653045002488 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045002489 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045002490 DNA binding residues [nucleotide binding] 653045002491 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 653045002492 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002493 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045002494 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045002495 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045002496 short chain dehydrogenase; Provisional; Region: PRK05872 653045002497 classical (c) SDRs; Region: SDR_c; cd05233 653045002498 NAD(P) binding site [chemical binding]; other site 653045002499 active site 653045002500 Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946 653045002501 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 653045002502 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 653045002503 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 653045002504 protein binding site [polypeptide binding]; other site 653045002505 Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562 653045002506 Domain interface; other site 653045002507 Peptide binding site; other site 653045002508 Active site tetrad [active] 653045002509 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045002510 Helix-turn-helix domains; Region: HTH; cl00088 653045002511 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045002512 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 653045002513 PDGLE domain; Region: PDGLE; cl07986 653045002514 Cobalt transport protein; Region: CbiQ; cl00463 653045002515 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 653045002516 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 653045002517 Walker A/P-loop; other site 653045002518 ATP binding site [chemical binding]; other site 653045002519 Q-loop/lid; other site 653045002520 ABC transporter signature motif; other site 653045002521 Walker B; other site 653045002522 D-loop; other site 653045002523 H-loop/switch region; other site 653045002524 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045002525 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045002526 classical (c) SDRs; Region: SDR_c; cd05233 653045002527 NAD(P) binding site [chemical binding]; other site 653045002528 active site 653045002529 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 653045002530 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 653045002531 peptide binding site [polypeptide binding]; other site 653045002532 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045002533 Helix-turn-helix domains; Region: HTH; cl00088 653045002534 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045002535 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 653045002536 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045002537 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045002538 non-specific DNA binding site [nucleotide binding]; other site 653045002539 salt bridge; other site 653045002540 sequence-specific DNA binding site [nucleotide binding]; other site 653045002541 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 653045002542 putative deacylase active site [active] 653045002543 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 653045002544 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045002545 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045002546 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 653045002547 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045002548 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 653045002549 active site 653045002550 Domain of unknown function (DUF348); Region: DUF348; pfam03990 653045002551 Domain of unknown function (DUF348); Region: DUF348; pfam03990 653045002552 Domain of unknown function (DUF348); Region: DUF348; pfam03990 653045002553 G5 domain; Region: G5; pfam07501 653045002554 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 653045002555 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045002556 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 653045002557 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 653045002558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045002559 Walker A/P-loop; other site 653045002560 ATP binding site [chemical binding]; other site 653045002561 Q-loop/lid; other site 653045002562 ABC transporter signature motif; other site 653045002563 Walker B; other site 653045002564 D-loop; other site 653045002565 H-loop/switch region; other site 653045002566 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 653045002567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045002568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045002569 DNA binding residues [nucleotide binding] 653045002570 dimerization interface [polypeptide binding]; other site 653045002571 Sodium:solute symporter family; Region: SSF; cl00456 653045002572 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 653045002573 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 653045002574 dimer interface [polypeptide binding]; other site 653045002575 active site 653045002576 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 653045002577 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 653045002578 NAD binding site [chemical binding]; other site 653045002579 homodimer interface [polypeptide binding]; other site 653045002580 active site 653045002581 substrate binding site [chemical binding]; other site 653045002582 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 653045002583 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 653045002584 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 653045002585 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 653045002586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045002587 active site 653045002588 dimerization interface [polypeptide binding]; other site 653045002589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045002590 DNA binding residues [nucleotide binding] 653045002591 Helix-turn-helix domains; Region: HTH; cl00088 653045002592 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 653045002593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045002594 S-adenosylmethionine binding site [chemical binding]; other site 653045002595 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 653045002596 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045002597 dimer interface [polypeptide binding]; other site 653045002598 putative metal binding site [ion binding]; other site 653045002599 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002600 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045002601 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045002602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045002603 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045002604 non-specific DNA binding site [nucleotide binding]; other site 653045002605 salt bridge; other site 653045002606 sequence-specific DNA binding site [nucleotide binding]; other site 653045002607 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045002608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045002609 Helix-turn-helix domains; Region: HTH; cl00088 653045002610 Fatty acid desaturase; Region: FA_desaturase; pfam00487 653045002611 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 653045002612 Di-iron ligands [ion binding]; other site 653045002613 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 653045002614 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 653045002615 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 653045002616 putative active site [active] 653045002617 catalytic residue [active] 653045002618 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 653045002619 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 653045002620 5S rRNA interface [nucleotide binding]; other site 653045002621 CTC domain interface [polypeptide binding]; other site 653045002622 L16 interface [polypeptide binding]; other site 653045002623 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 653045002624 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 653045002625 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 653045002626 active site 653045002627 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 653045002628 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 653045002629 Substrate binding site; other site 653045002630 Mg++ binding site; other site 653045002631 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 653045002632 active site 653045002633 substrate binding site [chemical binding]; other site 653045002634 CoA binding site [chemical binding]; other site 653045002635 Histidine kinase; Region: HisKA_3; pfam07730 653045002636 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045002637 SUKH-3 immunity protein; Region: SUKH-3; pfam14433 653045002638 YwqJ-like deaminase; Region: YwqJ-deaminase; pfam14431 653045002639 DNase/tRNase domain of colicin-like bacteriocin; Region: Colicin-DNase; cl15861 653045002640 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 653045002641 Xanthomonas XOO_2897-like deaminase; Region: XOO_2897-deam; pfam14440 653045002642 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 653045002643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045002644 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045002645 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045002646 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045002647 Walker A/P-loop; other site 653045002648 ATP binding site [chemical binding]; other site 653045002649 Q-loop/lid; other site 653045002650 ABC transporter signature motif; other site 653045002651 Walker B; other site 653045002652 D-loop; other site 653045002653 H-loop/switch region; other site 653045002654 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045002655 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 653045002656 FtsX-like permease family; Region: FtsX; cl15850 653045002657 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 653045002658 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045002659 FtsX-like permease family; Region: FtsX; cl15850 653045002660 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045002661 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045002662 active site 653045002663 catalytic tetrad [active] 653045002664 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045002665 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 653045002666 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 653045002667 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045002668 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045002669 active site 653045002670 Helix-turn-helix domains; Region: HTH; cl00088 653045002671 Gas vesicle protein K; Region: GvpK; pfam05121 653045002672 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045002673 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 653045002674 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045002675 Gas vesicle protein G; Region: GvpG; pfam05120 653045002676 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 653045002677 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045002678 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 653045002679 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 653045002680 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 653045002681 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045002682 ATP binding site [chemical binding]; other site 653045002683 putative Mg++ binding site [ion binding]; other site 653045002684 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045002685 nucleotide binding region [chemical binding]; other site 653045002686 ATP-binding site [chemical binding]; other site 653045002687 TRCF domain; Region: TRCF; cl04088 653045002688 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 653045002689 putative active site [active] 653045002690 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045002691 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 653045002692 Helix-turn-helix domains; Region: HTH; cl00088 653045002693 Helix-turn-helix domains; Region: HTH; cl00088 653045002694 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 653045002695 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045002696 Walker A/P-loop; other site 653045002697 ATP binding site [chemical binding]; other site 653045002698 Q-loop/lid; other site 653045002699 ABC transporter signature motif; other site 653045002700 Walker B; other site 653045002701 D-loop; other site 653045002702 H-loop/switch region; other site 653045002703 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045002704 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045002705 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045002706 Walker A/P-loop; other site 653045002707 ATP binding site [chemical binding]; other site 653045002708 Q-loop/lid; other site 653045002709 ABC transporter signature motif; other site 653045002710 Walker B; other site 653045002711 D-loop; other site 653045002712 H-loop/switch region; other site 653045002713 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045002714 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 653045002715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045002716 dimer interface [polypeptide binding]; other site 653045002717 conserved gate region; other site 653045002718 putative PBP binding loops; other site 653045002719 ABC-ATPase subunit interface; other site 653045002720 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045002721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045002722 dimer interface [polypeptide binding]; other site 653045002723 conserved gate region; other site 653045002724 putative PBP binding loops; other site 653045002725 ABC-ATPase subunit interface; other site 653045002726 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045002727 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045002728 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045002729 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045002730 DNA-binding site [nucleotide binding]; DNA binding site 653045002731 FCD domain; Region: FCD; cl11656 653045002732 Helix-turn-helix domains; Region: HTH; cl00088 653045002733 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045002734 dimerization interface [polypeptide binding]; other site 653045002735 substrate binding pocket [chemical binding]; other site 653045002736 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045002737 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045002738 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045002739 classical (c) SDRs; Region: SDR_c; cd05233 653045002740 NAD(P) binding site [chemical binding]; other site 653045002741 active site 653045002742 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 653045002743 Helix-turn-helix domains; Region: HTH; cl00088 653045002744 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045002745 dimerization interface [polypeptide binding]; other site 653045002746 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 653045002747 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 653045002748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045002749 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045002750 ATP binding site [chemical binding]; other site 653045002751 Mg2+ binding site [ion binding]; other site 653045002752 G-X-G motif; other site 653045002753 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045002754 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045002755 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045002756 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 653045002757 G1 box; other site 653045002758 GTP/Mg2+ binding site [chemical binding]; other site 653045002759 G2 box; other site 653045002760 Switch I region; other site 653045002761 G3 box; other site 653045002762 Switch II region; other site 653045002763 G4 box; other site 653045002764 G5 box; other site 653045002765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045002766 non-specific DNA binding site [nucleotide binding]; other site 653045002767 salt bridge; other site 653045002768 sequence-specific DNA binding site [nucleotide binding]; other site 653045002769 Cupin domain; Region: Cupin_2; cl09118 653045002770 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045002771 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045002772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045002773 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045002774 substrate binding pocket [chemical binding]; other site 653045002775 Helix-turn-helix domains; Region: HTH; cl00088 653045002776 WYL domain; Region: WYL; cl14852 653045002777 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 653045002778 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045002779 DNA binding residues [nucleotide binding] 653045002780 drug binding residues [chemical binding]; other site 653045002781 dimer interface [polypeptide binding]; other site 653045002782 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 653045002783 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 653045002784 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 653045002785 metal ion-dependent adhesion site (MIDAS); other site 653045002786 Helix-turn-helix domains; Region: HTH; cl00088 653045002787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045002788 S-adenosylmethionine binding site [chemical binding]; other site 653045002789 Putative SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_2; cl00827 653045002790 NADH:ubiquinone oxidoreductase, Na(+)-translocating, F subunit; Region: nqrF; TIGR01941 653045002791 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045002792 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 653045002793 B12 binding site [chemical binding]; other site 653045002794 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045002795 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 653045002796 catalytic residues [active] 653045002797 catalytic nucleophile [active] 653045002798 Recombinase; Region: Recombinase; pfam07508 653045002799 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 653045002800 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045002801 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045002802 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045002803 DNA-binding site [nucleotide binding]; DNA binding site 653045002804 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045002805 non-specific DNA binding site [nucleotide binding]; other site 653045002806 salt bridge; other site 653045002807 sequence-specific DNA binding site [nucleotide binding]; other site 653045002808 Flavoprotein; Region: Flavoprotein; cl08021 653045002809 DNA polymerase III subunit delta'; Validated; Region: PRK06090 653045002810 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 653045002811 Molecular chaperone, HSP90 family [Posttranslational modification, protein turnover, chaperones]; Region: HtpG; COG0326 653045002812 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 653045002813 cystathionine gamma-synthase; Provisional; Region: PRK07811 653045002814 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 653045002815 homodimer interface [polypeptide binding]; other site 653045002816 substrate-cofactor binding pocket; other site 653045002817 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045002818 catalytic residue [active] 653045002819 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045002820 DNA binding residues [nucleotide binding] 653045002821 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045002822 Helix-turn-helix domains; Region: HTH; cl00088 653045002823 threonine dehydratase; Provisional; Region: PRK08198 653045002824 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 653045002825 tetramer interface [polypeptide binding]; other site 653045002826 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045002827 catalytic residue [active] 653045002828 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 653045002829 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045002830 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045002831 active site 653045002832 catalytic tetrad [active] 653045002833 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 653045002834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045002835 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045002836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045002837 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045002838 Walker A/P-loop; other site 653045002839 ATP binding site [chemical binding]; other site 653045002840 Q-loop/lid; other site 653045002841 ABC transporter signature motif; other site 653045002842 Walker B; other site 653045002843 D-loop; other site 653045002844 H-loop/switch region; other site 653045002845 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045002846 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 653045002847 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 653045002848 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 653045002849 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 653045002850 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 653045002851 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045002852 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045002853 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045002854 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045002855 binding surface 653045002856 TPR motif; other site 653045002857 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 653045002858 Helix-turn-helix domains; Region: HTH; cl00088 653045002859 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045002860 dimerization interface [polypeptide binding]; other site 653045002861 substrate binding pocket [chemical binding]; other site 653045002862 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045002863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002864 NAD(P) binding site [chemical binding]; other site 653045002865 active site 653045002866 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045002867 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045002868 active site 653045002869 ATP binding site [chemical binding]; other site 653045002870 substrate binding site [chemical binding]; other site 653045002871 activation loop (A-loop); other site 653045002872 mercuric reductase; Validated; Region: PRK06370 653045002873 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045002874 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 653045002875 malate dehydrogenase; Provisional; Region: PRK13529 653045002876 Malic enzyme, N-terminal domain; Region: malic; pfam00390 653045002877 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045002878 NAD(P) binding pocket [chemical binding]; other site 653045002879 fumarate hydratase; Reviewed; Region: fumC; PRK00485 653045002880 Class II fumarases; Region: Fumarase_classII; cd01362 653045002881 active site 653045002882 tetramer interface [polypeptide binding]; other site 653045002883 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 653045002884 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 653045002885 catalytic residues [active] 653045002886 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 653045002887 Helix-turn-helix domains; Region: HTH; cl00088 653045002888 Haemolysin-III related; Region: HlyIII; cl03831 653045002889 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 653045002890 Phosphoenolpyruvate carboxykinase; Region: PEPCK; pfam00821 653045002891 active site 653045002892 substrate-binding site [chemical binding]; other site 653045002893 metal-binding site [ion binding] 653045002894 GTP binding site [chemical binding]; other site 653045002895 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 653045002896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045002897 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 653045002898 metal ion-dependent adhesion site (MIDAS); other site 653045002899 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045002900 Probable transposase; Region: OrfB_IS605; pfam01385 653045002901 alanine aminotransferase; Validated; Region: PRK08363 653045002902 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045002903 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045002904 homodimer interface [polypeptide binding]; other site 653045002905 catalytic residue [active] 653045002906 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 653045002907 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045002908 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045002909 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045002910 dimer interface [polypeptide binding]; other site 653045002911 conserved gate region; other site 653045002912 putative PBP binding loops; other site 653045002913 ABC-ATPase subunit interface; other site 653045002914 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 653045002915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045002916 ABC-ATPase subunit interface; other site 653045002917 putative PBP binding loops; other site 653045002918 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 653045002919 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045002920 Walker A/P-loop; other site 653045002921 ATP binding site [chemical binding]; other site 653045002922 Q-loop/lid; other site 653045002923 ABC transporter signature motif; other site 653045002924 Walker B; other site 653045002925 D-loop; other site 653045002926 H-loop/switch region; other site 653045002927 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045002928 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045002929 Walker A/P-loop; other site 653045002930 ATP binding site [chemical binding]; other site 653045002931 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045002932 Q-loop/lid; other site 653045002933 ABC transporter signature motif; other site 653045002934 Walker B; other site 653045002935 D-loop; other site 653045002936 H-loop/switch region; other site 653045002937 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 653045002938 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045002939 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045002940 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045002941 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045002942 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045002943 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045002944 DNA binding residues [nucleotide binding] 653045002945 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 653045002946 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 653045002947 active site 653045002948 putative substrate binding pocket [chemical binding]; other site 653045002949 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045002950 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 653045002951 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818 653045002952 dimer interface [polypeptide binding]; other site 653045002953 active site 653045002954 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045002955 substrate binding site [chemical binding]; other site 653045002956 catalytic residue [active] 653045002957 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045002958 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 653045002959 substrate binding site [chemical binding]; other site 653045002960 ATP binding site [chemical binding]; other site 653045002961 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045002962 Helix-turn-helix domains; Region: HTH; cl00088 653045002963 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045002964 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 653045002965 homotrimer interaction site [polypeptide binding]; other site 653045002966 putative active site [active] 653045002967 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 653045002968 GntP family permease; Region: GntP_permease; pfam02447 653045002969 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045002970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045002971 Walker A/P-loop; other site 653045002972 ATP binding site [chemical binding]; other site 653045002973 Q-loop/lid; other site 653045002974 ABC transporter signature motif; other site 653045002975 Walker B; other site 653045002976 D-loop; other site 653045002977 H-loop/switch region; other site 653045002978 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045002979 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 653045002980 translocation protein TolB; Provisional; Region: tolB; PRK04792 653045002981 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 653045002982 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 653045002983 Phosphoesterase family; Region: Phosphoesterase; cl15450 653045002984 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045002985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045002986 non-specific DNA binding site [nucleotide binding]; other site 653045002987 salt bridge; other site 653045002988 sequence-specific DNA binding site [nucleotide binding]; other site 653045002989 protein-L-isoaspartate(D-aspartate) O-methyltransferase; Region: pimt; TIGR00080 653045002990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045002991 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 653045002992 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 653045002993 SpaB C-terminal domain; Region: SpaB_C; cl14828 653045002994 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 653045002995 active site 653045002996 zinc binding site [ion binding]; other site 653045002997 SpaB C-terminal domain; Region: SpaB_C; cl14828 653045002998 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 653045002999 putative active site [active] 653045003000 Zn binding site [ion binding]; other site 653045003001 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045003002 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 653045003003 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 653045003004 putative active site [active] 653045003005 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 653045003006 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 653045003007 Interdomain contacts; other site 653045003008 Cytokine receptor motif; other site 653045003009 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 653045003010 putative active site [active] 653045003011 SAF domain; Region: SAF; cl00555 653045003012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 653045003013 active site 653045003014 dimerization interface [polypeptide binding]; other site 653045003015 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 653045003016 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 653045003017 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 653045003018 ATP binding site [chemical binding]; other site 653045003019 Walker A motif; other site 653045003020 hexamer interface [polypeptide binding]; other site 653045003021 Walker B motif; other site 653045003022 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 653045003023 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 653045003024 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 653045003025 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 653045003026 ligand binding site [chemical binding]; other site 653045003027 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 653045003028 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 653045003029 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045003030 DNA-binding site [nucleotide binding]; DNA binding site 653045003031 RNA-binding motif; other site 653045003032 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 653045003033 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 653045003034 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 653045003035 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 653045003036 catalytic residue [active] 653045003037 putative FPP diphosphate binding site; other site 653045003038 putative FPP binding hydrophobic cleft; other site 653045003039 dimer interface [polypeptide binding]; other site 653045003040 putative IPP diphosphate binding site; other site 653045003041 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 653045003042 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 653045003043 putative active site [active] 653045003044 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003045 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 653045003046 N-acetyl-D-glucosamine binding site [chemical binding]; other site 653045003047 catalytic residue [active] 653045003048 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 653045003049 alkylhydroperoxidase, AhpD family; Region: ahpD; TIGR00777 653045003050 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045003051 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 653045003052 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 653045003053 dimer interface [polypeptide binding]; other site 653045003054 decamer (pentamer of dimers) interface [polypeptide binding]; other site 653045003055 catalytic triad [active] 653045003056 peroxidatic and resolving cysteines [active] 653045003057 Helix-turn-helix domains; Region: HTH; cl00088 653045003058 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 653045003059 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 653045003060 dimerization interface [polypeptide binding]; other site 653045003061 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045003062 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045003063 Walker A/P-loop; other site 653045003064 ATP binding site [chemical binding]; other site 653045003065 Q-loop/lid; other site 653045003066 ABC transporter signature motif; other site 653045003067 Walker B; other site 653045003068 D-loop; other site 653045003069 H-loop/switch region; other site 653045003070 Helix-turn-helix domains; Region: HTH; cl00088 653045003071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 653045003072 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 653045003073 Transglycosylase; Region: Transgly; cl07896 653045003074 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 653045003075 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045003076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045003077 Helix-turn-helix domains; Region: HTH; cl00088 653045003078 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045003079 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003080 Methyltransferase domain; Region: Methyltransf_31; pfam13847 653045003081 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045003082 S-adenosylmethionine binding site [chemical binding]; other site 653045003083 Protein of unknown function (DUF402); Region: DUF402; cl00979 653045003084 fumarate hydratase; Reviewed; Region: fumC; PRK00485 653045003085 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 653045003086 active sites [active] 653045003087 tetramer interface [polypeptide binding]; other site 653045003088 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 653045003089 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 653045003090 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 653045003091 DXD motif; other site 653045003092 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 653045003093 active site 653045003094 fumarate hydratase; Provisional; Region: PRK15389 653045003095 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 653045003096 Fumarase C-terminus; Region: Fumerase_C; cl00795 653045003097 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 653045003098 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 653045003099 Transcription factor WhiB; Region: Whib; pfam02467 653045003100 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 653045003101 putative active site [active] 653045003102 Protein of unknown function (DUF4245); Region: DUF4245; pfam14030 653045003103 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 653045003104 putative FMN binding site [chemical binding]; other site 653045003105 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 653045003106 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 653045003107 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 653045003108 generic binding surface II; other site 653045003109 generic binding surface I; other site 653045003110 LytB protein; Region: LYTB; cl00507 653045003111 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 653045003112 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045003113 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045003114 GTP-binding protein YchF; Reviewed; Region: PRK09601 653045003115 YchF GTPase; Region: YchF; cd01900 653045003116 G1 box; other site 653045003117 GTP/Mg2+ binding site [chemical binding]; other site 653045003118 Switch I region; other site 653045003119 G2 box; other site 653045003120 Switch II region; other site 653045003121 G3 box; other site 653045003122 G4 box; other site 653045003123 G5 box; other site 653045003124 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 653045003125 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045003126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045003127 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045003128 Walker A/P-loop; other site 653045003129 ATP binding site [chemical binding]; other site 653045003130 Q-loop/lid; other site 653045003131 ABC transporter signature motif; other site 653045003132 Walker B; other site 653045003133 D-loop; other site 653045003134 H-loop/switch region; other site 653045003135 Helix-turn-helix domains; Region: HTH; cl00088 653045003136 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 653045003137 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045003138 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 653045003139 active site 653045003140 putative transposase OrfB; Reviewed; Region: PHA02517 653045003141 HTH-like domain; Region: HTH_21; pfam13276 653045003142 Integrase core domain; Region: rve; cl01316 653045003143 Integrase core domain; Region: rve_3; cl15866 653045003144 TIR domain; Region: TIR_2; cl15770 653045003145 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045003146 non-specific DNA binding site [nucleotide binding]; other site 653045003147 salt bridge; other site 653045003148 sequence-specific DNA binding site [nucleotide binding]; other site 653045003149 Archaeal ATPase; Region: Arch_ATPase; pfam01637 653045003150 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003151 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 653045003152 classical (c) SDRs; Region: SDR_c; cd05233 653045003153 NAD(P) binding site [chemical binding]; other site 653045003154 active site 653045003155 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045003156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045003157 active site 653045003158 phosphorylation site [posttranslational modification] 653045003159 intermolecular recognition site; other site 653045003160 dimerization interface [polypeptide binding]; other site 653045003161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045003162 DNA binding site [nucleotide binding] 653045003163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045003164 dimerization interface [polypeptide binding]; other site 653045003165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045003166 dimer interface [polypeptide binding]; other site 653045003167 phosphorylation site [posttranslational modification] 653045003168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045003169 ATP binding site [chemical binding]; other site 653045003170 Mg2+ binding site [ion binding]; other site 653045003171 G-X-G motif; other site 653045003172 Helix-turn-helix domains; Region: HTH; cl00088 653045003173 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 653045003174 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003175 NAD(P) binding site [chemical binding]; other site 653045003176 active site 653045003177 benzoate transport; Region: 2A0115; TIGR00895 653045003178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045003179 putative substrate translocation pore; other site 653045003180 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045003181 classical (c) SDRs; Region: SDR_c; cd05233 653045003182 NAD(P) binding site [chemical binding]; other site 653045003183 active site 653045003184 Helix-turn-helix domains; Region: HTH; cl00088 653045003185 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045003186 dimerization interface [polypeptide binding]; other site 653045003187 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045003188 putative active site [active] 653045003189 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 653045003190 Zn binding site [ion binding]; other site 653045003191 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045003192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045003193 DNA-binding site [nucleotide binding]; DNA binding site 653045003194 UTRA domain; Region: UTRA; cl01230 653045003195 Sodium:solute symporter family; Region: SSF; cl00456 653045003196 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 653045003197 Spore germination protein; Region: Spore_permease; cl15802 653045003198 rare lipoprotein A; Provisional; Region: PRK10672 653045003199 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 653045003200 active site 653045003201 8-oxo-dGMP binding site [chemical binding]; other site 653045003202 nudix motif; other site 653045003203 metal binding site [ion binding]; metal-binding site 653045003204 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045003205 PAS domain; Region: PAS_9; pfam13426 653045003206 PAS fold; Region: PAS_4; pfam08448 653045003207 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045003208 putative active site [active] 653045003209 heme pocket [chemical binding]; other site 653045003210 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 653045003211 GAF domain; Region: GAF; cl15785 653045003212 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045003213 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045003214 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045003215 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003216 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 653045003217 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045003218 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 653045003219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003220 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 653045003221 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045003222 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045003223 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045003224 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 653045003225 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 653045003226 G1 box; other site 653045003227 putative GEF interaction site [polypeptide binding]; other site 653045003228 GTP/Mg2+ binding site [chemical binding]; other site 653045003229 Switch I region; other site 653045003230 G2 box; other site 653045003231 G3 box; other site 653045003232 Switch II region; other site 653045003233 G4 box; other site 653045003234 G5 box; other site 653045003235 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 653045003236 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 653045003237 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 653045003238 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 653045003239 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045003240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003241 dimer interface [polypeptide binding]; other site 653045003242 conserved gate region; other site 653045003243 putative PBP binding loops; other site 653045003244 ABC-ATPase subunit interface; other site 653045003245 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 653045003246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003247 dimer interface [polypeptide binding]; other site 653045003248 conserved gate region; other site 653045003249 putative PBP binding loops; other site 653045003250 ABC-ATPase subunit interface; other site 653045003251 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045003252 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045003253 Walker A/P-loop; other site 653045003254 ATP binding site [chemical binding]; other site 653045003255 Q-loop/lid; other site 653045003256 ABC transporter signature motif; other site 653045003257 Walker B; other site 653045003258 D-loop; other site 653045003259 H-loop/switch region; other site 653045003260 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045003261 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 653045003262 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045003263 Walker A/P-loop; other site 653045003264 ATP binding site [chemical binding]; other site 653045003265 Q-loop/lid; other site 653045003266 ABC transporter signature motif; other site 653045003267 Walker B; other site 653045003268 D-loop; other site 653045003269 H-loop/switch region; other site 653045003270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045003271 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045003272 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045003274 non-specific DNA binding site [nucleotide binding]; other site 653045003275 salt bridge; other site 653045003276 sequence-specific DNA binding site [nucleotide binding]; other site 653045003277 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045003278 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 653045003279 Epoxide hydrolase N terminus; Region: EHN; pfam06441 653045003280 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045003281 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 653045003282 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 653045003283 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045003284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045003285 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 653045003286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003287 dimer interface [polypeptide binding]; other site 653045003288 conserved gate region; other site 653045003289 putative PBP binding loops; other site 653045003290 ABC-ATPase subunit interface; other site 653045003291 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045003292 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045003293 Walker A/P-loop; other site 653045003294 ATP binding site [chemical binding]; other site 653045003295 Q-loop/lid; other site 653045003296 ABC transporter signature motif; other site 653045003297 Walker B; other site 653045003298 D-loop; other site 653045003299 H-loop/switch region; other site 653045003300 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045003301 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 653045003302 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045003303 Walker A/P-loop; other site 653045003304 ATP binding site [chemical binding]; other site 653045003305 Q-loop/lid; other site 653045003306 ABC transporter signature motif; other site 653045003307 Walker B; other site 653045003308 D-loop; other site 653045003309 H-loop/switch region; other site 653045003310 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045003311 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 653045003312 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045003313 Walker A/P-loop; other site 653045003314 ATP binding site [chemical binding]; other site 653045003315 Q-loop/lid; other site 653045003316 ABC transporter signature motif; other site 653045003317 Walker B; other site 653045003318 D-loop; other site 653045003319 H-loop/switch region; other site 653045003320 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045003321 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045003322 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045003323 Walker A/P-loop; other site 653045003324 ATP binding site [chemical binding]; other site 653045003325 Q-loop/lid; other site 653045003326 ABC transporter signature motif; other site 653045003327 Walker B; other site 653045003328 D-loop; other site 653045003329 H-loop/switch region; other site 653045003330 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045003331 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045003332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003333 dimer interface [polypeptide binding]; other site 653045003334 conserved gate region; other site 653045003335 putative PBP binding loops; other site 653045003336 ABC-ATPase subunit interface; other site 653045003337 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 653045003338 peptide binding site [polypeptide binding]; other site 653045003339 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045003340 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 653045003341 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 653045003342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003343 dimer interface [polypeptide binding]; other site 653045003344 conserved gate region; other site 653045003345 putative PBP binding loops; other site 653045003346 ABC-ATPase subunit interface; other site 653045003347 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 653045003348 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 653045003349 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045003350 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 653045003351 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 653045003352 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045003353 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 653045003354 Walker A/P-loop; other site 653045003355 ATP binding site [chemical binding]; other site 653045003356 Q-loop/lid; other site 653045003357 ABC transporter signature motif; other site 653045003358 Walker B; other site 653045003359 D-loop; other site 653045003360 H-loop/switch region; other site 653045003361 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045003362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045003363 Histidine kinase; Region: HisKA_3; pfam07730 653045003364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045003366 active site 653045003367 phosphorylation site [posttranslational modification] 653045003368 intermolecular recognition site; other site 653045003369 dimerization interface [polypeptide binding]; other site 653045003370 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045003371 DNA binding residues [nucleotide binding] 653045003372 dimerization interface [polypeptide binding]; other site 653045003373 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 653045003374 Tetratricopeptide repeat; Region: TPR_9; pfam13371 653045003375 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 653045003376 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045003377 Ferredoxin [Energy production and conversion]; Region: COG1146 653045003378 4Fe-4S binding domain; Region: Fer4; cl02805 653045003379 succinyldiaminopimelate transaminase; Region: DapC_actino; TIGR03539 653045003380 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045003381 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045003382 homodimer interface [polypeptide binding]; other site 653045003383 catalytic residue [active] 653045003384 succinyl-diaminopimelate desuccinylase; Region: dapE-gram_pos; TIGR01900 653045003385 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 653045003386 metal binding site [ion binding]; metal-binding site 653045003387 putative dimer interface [polypeptide binding]; other site 653045003388 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 653045003389 dihydropteroate synthase; Region: DHPS; TIGR01496 653045003390 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 653045003391 substrate binding pocket [chemical binding]; other site 653045003392 dimer interface [polypeptide binding]; other site 653045003393 inhibitor binding site; inhibition site 653045003394 DivIVA domain; Region: DivI1A_domain; TIGR03544 653045003395 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 653045003396 enoyl-CoA hydratase; Provisional; Region: PRK08140 653045003397 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045003398 substrate binding site [chemical binding]; other site 653045003399 oxyanion hole (OAH) forming residues; other site 653045003400 trimer interface [polypeptide binding]; other site 653045003401 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 653045003402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045003403 S-adenosylmethionine binding site [chemical binding]; other site 653045003404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045003405 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045003406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045003407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045003408 DNA binding residues [nucleotide binding] 653045003409 Putative zinc-finger; Region: zf-HC2; cl15806 653045003410 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045003411 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 653045003412 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 653045003413 Domain of unknown function DUF59; Region: DUF59; cl00941 653045003414 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 653045003415 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 653045003416 Protein of unknown function (DUF1003); Region: DUF1003; cl01831 653045003417 MgtE intracellular N domain; Region: MgtE_N; cl15244 653045003418 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 653045003419 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 653045003420 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 653045003421 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 653045003422 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 653045003423 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 653045003424 MarC family integral membrane protein; Region: MarC; cl00919 653045003425 LabA_like proteins; Region: LabA_like; cd06167 653045003426 putative metal binding site [ion binding]; other site 653045003427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045003428 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 653045003429 DEAD-like helicases superfamily; Region: DEXDc; smart00487 653045003430 ATP binding site [chemical binding]; other site 653045003431 Mg++ binding site [ion binding]; other site 653045003432 motif III; other site 653045003433 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045003434 nucleotide binding region [chemical binding]; other site 653045003435 ATP-binding site [chemical binding]; other site 653045003436 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 653045003437 dinuclear metal binding motif [ion binding]; other site 653045003438 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 653045003439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045003440 Helix-turn-helix domains; Region: HTH; cl00088 653045003441 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045003442 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045003443 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 653045003444 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045003445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003446 NAD(P) binding site [chemical binding]; other site 653045003447 active site 653045003448 Spherulation-specific family 4; Region: Spherulin4; pfam12138 653045003449 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 653045003450 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 653045003451 ATP binding site [chemical binding]; other site 653045003452 substrate interface [chemical binding]; other site 653045003453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 653045003454 active site residue [active] 653045003455 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045003456 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045003457 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 653045003458 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045003459 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045003460 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 653045003461 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 653045003462 active site 653045003463 DNA binding site [nucleotide binding] 653045003464 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 653045003465 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003466 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 653045003467 Family description; Region: UvrD_C_2; cl15862 653045003468 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 653045003469 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 653045003470 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 653045003471 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003472 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 653045003473 hypothetical protein; Provisional; Region: PRK08201 653045003474 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 653045003475 metal binding site [ion binding]; metal-binding site 653045003476 putative dimer interface [polypeptide binding]; other site 653045003477 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 653045003478 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 653045003479 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 653045003480 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 653045003481 putative NADH binding site [chemical binding]; other site 653045003482 putative active site [active] 653045003483 nudix motif; other site 653045003484 putative metal binding site [ion binding]; other site 653045003485 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 653045003486 catalytic residues [active] 653045003487 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 653045003488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003489 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 653045003490 Family description; Region: UvrD_C_2; cl15862 653045003491 HRDC domain; Region: HRDC; cl02578 653045003492 Transcription factor WhiB; Region: Whib; pfam02467 653045003493 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045003494 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 653045003495 active site 653045003496 ATP binding site [chemical binding]; other site 653045003497 Protein of unknown function DUF45; Region: DUF45; cl00636 653045003498 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045003499 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045003500 putative metal binding site [ion binding]; other site 653045003501 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 653045003502 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 653045003503 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 653045003504 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 653045003505 nudix motif; other site 653045003506 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 653045003507 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 653045003508 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045003509 putative NAD(P) binding site [chemical binding]; other site 653045003510 active site 653045003511 putative substrate binding site [chemical binding]; other site 653045003512 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 653045003513 MoaE homodimer interface [polypeptide binding]; other site 653045003514 MoaD interaction [polypeptide binding]; other site 653045003515 active site residues [active] 653045003516 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 653045003517 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 653045003518 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 653045003519 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 653045003520 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 653045003521 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 653045003522 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 653045003523 metal binding site 2 [ion binding]; metal-binding site 653045003524 putative DNA binding helix; other site 653045003525 metal binding site 1 [ion binding]; metal-binding site 653045003526 dimer interface [polypeptide binding]; other site 653045003527 structural Zn2+ binding site [ion binding]; other site 653045003528 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 653045003529 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 653045003530 tetramer interface [polypeptide binding]; other site 653045003531 heme binding pocket [chemical binding]; other site 653045003532 NADPH binding site [chemical binding]; other site 653045003533 FOG: CBS domain [General function prediction only]; Region: COG0517 653045003534 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_11; cd04624 653045003535 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 653045003536 active site 653045003537 Helix-turn-helix domains; Region: HTH; cl00088 653045003538 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 653045003539 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 653045003540 GTPase/Zn-binding domain interface [polypeptide binding]; other site 653045003541 GTP/Mg2+ binding site [chemical binding]; other site 653045003542 G4 box; other site 653045003543 G5 box; other site 653045003544 G1 box; other site 653045003545 Switch I region; other site 653045003546 G2 box; other site 653045003547 G3 box; other site 653045003548 Switch II region; other site 653045003549 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 653045003550 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 653045003551 hinge; other site 653045003552 active site 653045003553 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 653045003554 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 653045003555 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 653045003556 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 653045003557 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045003558 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045003559 DNA binding residues [nucleotide binding] 653045003560 Putative zinc-finger; Region: zf-HC2; cl15806 653045003561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 653045003562 Zn2+ binding site [ion binding]; other site 653045003563 Mg2+ binding site [ion binding]; other site 653045003564 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045003565 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 653045003566 active site 653045003567 catalytic residues [active] 653045003568 metal binding site [ion binding]; metal-binding site 653045003569 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 653045003570 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 653045003571 dimer interface [polypeptide binding]; other site 653045003572 putative radical transfer pathway; other site 653045003573 diiron center [ion binding]; other site 653045003574 tyrosyl radical; other site 653045003575 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 653045003576 Class I ribonucleotide reductase; Region: RNR_I; cd01679 653045003577 active site 653045003578 dimer interface [polypeptide binding]; other site 653045003579 catalytic residues [active] 653045003580 effector binding site; other site 653045003581 R2 peptide binding site; other site 653045003582 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045003583 Protein of unknown function (DUF1360); Region: DUF1360; pfam07098 653045003584 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 653045003585 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045003586 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045003587 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045003588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045003589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003590 Sodium:solute symporter family; Region: SSF; cl00456 653045003591 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 653045003592 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045003593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045003594 DNA-binding site [nucleotide binding]; DNA binding site 653045003595 UTRA domain; Region: UTRA; cl01230 653045003596 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 653045003597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045003598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003599 putative PBP binding loops; other site 653045003600 dimer interface [polypeptide binding]; other site 653045003601 ABC-ATPase subunit interface; other site 653045003602 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045003603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003604 dimer interface [polypeptide binding]; other site 653045003605 conserved gate region; other site 653045003606 putative PBP binding loops; other site 653045003607 ABC-ATPase subunit interface; other site 653045003608 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045003609 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 653045003610 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 653045003611 dimer interface [polypeptide binding]; other site 653045003612 active site 653045003613 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 653045003614 dimer interface [polypeptide binding]; other site 653045003615 active site 653045003616 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 653045003617 PAS fold; Region: PAS_4; pfam08448 653045003618 Histidine kinase; Region: HisKA_2; cl06527 653045003619 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045003620 ATP binding site [chemical binding]; other site 653045003621 Mg2+ binding site [ion binding]; other site 653045003622 G-X-G motif; other site 653045003623 Transcription factor WhiB; Region: Whib; pfam02467 653045003624 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 653045003625 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 653045003626 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045003627 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045003628 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045003629 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045003630 DNA binding residues [nucleotide binding] 653045003631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003632 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045003633 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 653045003634 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 653045003635 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 653045003636 Glutaminase; Region: Glutaminase; cl00907 653045003637 Helix-turn-helix domain; Region: HTH_18; pfam12833 653045003638 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045003639 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045003640 active site 653045003641 metal binding site [ion binding]; metal-binding site 653045003642 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 653045003643 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 653045003644 dimer interface [polypeptide binding]; other site 653045003645 active site 653045003646 CoA binding pocket [chemical binding]; other site 653045003647 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045003648 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045003649 anti sigma factor interaction site; other site 653045003650 regulatory phosphorylation site [posttranslational modification]; other site 653045003651 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045003652 anti sigma factor interaction site; other site 653045003653 regulatory phosphorylation site [posttranslational modification]; other site 653045003654 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 653045003655 Helix-turn-helix domains; Region: HTH; cl00088 653045003656 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045003657 dimerization interface [polypeptide binding]; other site 653045003658 substrate binding pocket [chemical binding]; other site 653045003659 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045003660 PAS domain; Region: PAS_9; pfam13426 653045003661 PAS fold; Region: PAS_4; pfam08448 653045003662 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045003663 putative active site [active] 653045003664 heme pocket [chemical binding]; other site 653045003665 GAF domain; Region: GAF; cl15785 653045003666 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045003667 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045003668 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003669 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003670 NmrA-like family; Region: NmrA; pfam05368 653045003671 NAD(P) binding site [chemical binding]; other site 653045003672 active site 653045003673 Helix-turn-helix domains; Region: HTH; cl00088 653045003674 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 653045003675 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 653045003676 Catalytic site [active] 653045003677 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045003678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045003679 S-adenosylmethionine binding site [chemical binding]; other site 653045003680 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 653045003681 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 653045003682 Walker A/P-loop; other site 653045003683 ATP binding site [chemical binding]; other site 653045003684 Q-loop/lid; other site 653045003685 ABC transporter signature motif; other site 653045003686 Walker B; other site 653045003687 D-loop; other site 653045003688 H-loop/switch region; other site 653045003689 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 653045003690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045003691 dimer interface [polypeptide binding]; other site 653045003692 conserved gate region; other site 653045003693 putative PBP binding loops; other site 653045003694 ABC-ATPase subunit interface; other site 653045003695 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045003696 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045003697 substrate binding pocket [chemical binding]; other site 653045003698 membrane-bound complex binding site; other site 653045003699 hinge residues; other site 653045003700 Malic enzyme, N-terminal domain; Region: malic; pfam00390 653045003701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003702 NAD(P) binding pocket [chemical binding]; other site 653045003703 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045003704 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045003705 NAD(P) binding site [chemical binding]; other site 653045003706 Helix-turn-helix domains; Region: HTH; cl00088 653045003707 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 653045003708 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 653045003709 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045003710 AMP-binding enzyme; Region: AMP-binding; cl15778 653045003711 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045003712 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 653045003713 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045003714 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003715 NAD(P) binding site [chemical binding]; other site 653045003716 active site 653045003717 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045003718 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 653045003719 putative FMN binding site [chemical binding]; other site 653045003720 Helix-turn-helix domains; Region: HTH; cl00088 653045003721 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 653045003722 Helix-turn-helix domains; Region: HTH; cl00088 653045003723 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045003724 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 653045003725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003726 NAD(P) binding site [chemical binding]; other site 653045003727 active site 653045003728 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 653045003729 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045003730 DNA binding residues [nucleotide binding] 653045003731 putative dimer interface [polypeptide binding]; other site 653045003732 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 653045003733 alpha-ketoglutarate decarboxylase; Reviewed; Region: kgd; PRK12270 653045003734 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 653045003735 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 653045003736 TPP-binding site [chemical binding]; other site 653045003737 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 653045003738 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045003739 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045003740 dimerization interface [polypeptide binding]; other site 653045003741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045003742 dimer interface [polypeptide binding]; other site 653045003743 phosphorylation site [posttranslational modification] 653045003744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045003745 ATP binding site [chemical binding]; other site 653045003746 Mg2+ binding site [ion binding]; other site 653045003747 G-X-G motif; other site 653045003748 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045003749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045003750 active site 653045003751 phosphorylation site [posttranslational modification] 653045003752 intermolecular recognition site; other site 653045003753 dimerization interface [polypeptide binding]; other site 653045003754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045003755 DNA binding site [nucleotide binding] 653045003756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045003757 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 653045003758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045003759 ATP binding site [chemical binding]; other site 653045003760 Walker A motif; other site 653045003761 Walker B motif; other site 653045003762 arginine finger; other site 653045003763 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 653045003764 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045003765 putative active site [active] 653045003766 classical (c) SDRs; Region: SDR_c; cd05233 653045003767 NAD(P) binding site [chemical binding]; other site 653045003768 active site 653045003769 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045003770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045003771 Helix-turn-helix domains; Region: HTH; cl00088 653045003772 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 653045003773 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 653045003774 active site 653045003775 Helix-turn-helix domains; Region: HTH; cl00088 653045003776 Nitrate and nitrite sensing; Region: NIT; pfam08376 653045003777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045003778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045003779 ATP binding site [chemical binding]; other site 653045003780 Mg2+ binding site [ion binding]; other site 653045003781 G-X-G motif; other site 653045003782 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045003783 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045003784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003785 NlpC/P60 family; Region: NLPC_P60; cl11438 653045003786 Helix-turn-helix domains; Region: HTH; cl00088 653045003787 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 653045003788 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 653045003789 dinuclear metal binding motif [ion binding]; other site 653045003790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045003791 Coenzyme A binding pocket [chemical binding]; other site 653045003792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045003793 putative substrate translocation pore; other site 653045003794 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045003795 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045003796 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045003797 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045003798 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045003799 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045003800 Transcriptional regulators [Transcription]; Region: MarR; COG1846 653045003801 Helix-turn-helix domains; Region: HTH; cl00088 653045003802 Domain of unknown function (DUF427); Region: DUF427; cl00998 653045003803 Chitin binding domain; Region: Chitin_bind_3; cl03871 653045003804 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045003805 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045003806 DNA binding residues [nucleotide binding] 653045003807 TIGR02679 family protein; Region: TIGR02679 653045003808 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 653045003809 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 653045003810 TIGR02680 family protein; Region: TIGR02680 653045003811 TIGR02680 family protein; Region: TIGR02680 653045003812 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 653045003813 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 653045003814 TIGR02677 family protein; Region: TIGR02677 653045003815 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 653045003816 Predicted helicase [General function prediction only]; Region: COG4889 653045003817 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045003818 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045003819 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045003820 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045003821 binding surface 653045003822 TPR motif; other site 653045003823 Beta protein; Region: Beta_protein; pfam14350 653045003824 Uncharacterized conserved protein (DUF2366); Region: DUF2366; pfam10171 653045003825 Response regulator receiver domain; Region: Response_reg; pfam00072 653045003826 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045003827 active site 653045003828 phosphorylation site [posttranslational modification] 653045003829 intermolecular recognition site; other site 653045003830 dimerization interface [polypeptide binding]; other site 653045003831 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 653045003832 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 653045003833 anticodon binding site; other site 653045003834 tRNA binding surface [nucleotide binding]; other site 653045003835 diaminopimelate decarboxylase; Region: lysA; TIGR01048 653045003836 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 653045003837 active site 653045003838 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045003839 substrate binding site [chemical binding]; other site 653045003840 catalytic residues [active] 653045003841 dimer interface [polypeptide binding]; other site 653045003842 homoserine dehydrogenase; Provisional; Region: PRK06349 653045003843 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 653045003844 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 653045003845 threonine synthase; Reviewed; Region: PRK06721 653045003846 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 653045003847 homodimer interface [polypeptide binding]; other site 653045003848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045003849 catalytic residue [active] 653045003850 homoserine kinase; Provisional; Region: PRK01212 653045003851 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 653045003852 transcription termination factor Rho; Provisional; Region: PRK12608 653045003853 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 653045003854 RNA binding site [nucleotide binding]; other site 653045003855 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 653045003856 multimer interface [polypeptide binding]; other site 653045003857 Walker A motif; other site 653045003858 ATP binding site [chemical binding]; other site 653045003859 Walker B motif; other site 653045003860 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045003861 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 653045003862 peptide chain release factor 1; Validated; Region: prfA; PRK00591 653045003863 RF-1 domain; Region: RF-1; cl02875 653045003864 RF-1 domain; Region: RF-1; cl02875 653045003865 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 653045003866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045003867 S-adenosylmethionine binding site [chemical binding]; other site 653045003868 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 653045003869 Low molecular weight phosphatase family; Region: LMWPc; cl00105 653045003870 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 653045003871 active site 653045003872 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 653045003873 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 653045003874 dimer interface [polypeptide binding]; other site 653045003875 active site 653045003876 glycine-pyridoxal phosphate binding site [chemical binding]; other site 653045003877 folate binding site [chemical binding]; other site 653045003878 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 653045003879 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 653045003880 Mg++ binding site [ion binding]; other site 653045003881 putative catalytic motif [active] 653045003882 substrate binding site [chemical binding]; other site 653045003883 ATP synthase A chain; Region: ATP-synt_A; cl00413 653045003884 ATP synthase subunit C; Region: ATP-synt_C; cl00466 653045003885 Plant ATP synthase F0; Region: YMF19; cl07975 653045003886 Plant ATP synthase F0; Region: YMF19; cl07975 653045003887 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 653045003888 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 653045003889 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 653045003890 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 653045003891 beta subunit interaction interface [polypeptide binding]; other site 653045003892 Walker A motif; other site 653045003893 ATP binding site [chemical binding]; other site 653045003894 Walker B motif; other site 653045003895 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 653045003896 ATP synthase; Region: ATP-synt; cl00365 653045003897 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 653045003898 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 653045003899 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 653045003900 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 653045003901 alpha subunit interaction interface [polypeptide binding]; other site 653045003902 Walker A motif; other site 653045003903 ATP binding site [chemical binding]; other site 653045003904 Walker B motif; other site 653045003905 inhibitor binding site; inhibition site 653045003906 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 653045003907 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 653045003908 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 653045003909 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045003910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045003911 active site 653045003912 phosphorylation site [posttranslational modification] 653045003913 intermolecular recognition site; other site 653045003914 dimerization interface [polypeptide binding]; other site 653045003915 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045003916 DNA binding residues [nucleotide binding] 653045003917 dimerization interface [polypeptide binding]; other site 653045003918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 653045003919 Histidine kinase; Region: HisKA_3; pfam07730 653045003920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045003921 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 653045003922 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045003923 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 653045003924 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003925 Walker A/P-loop; other site 653045003926 ATP binding site [chemical binding]; other site 653045003927 Q-loop/lid; other site 653045003928 ABC transporter signature motif; other site 653045003929 Walker B; other site 653045003930 D-loop; other site 653045003931 H-loop/switch region; other site 653045003932 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045003933 Helix-turn-helix domains; Region: HTH; cl00088 653045003934 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 653045003935 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045003936 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045003937 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045003938 anti sigma factor interaction site; other site 653045003939 regulatory phosphorylation site [posttranslational modification]; other site 653045003940 AAA domain; Region: AAA_22; pfam13401 653045003941 Protein of unknown function DUF91; Region: DUF91; cl00709 653045003942 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045003943 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 653045003944 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 653045003945 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045003946 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 653045003947 Walker A/P-loop; other site 653045003948 ATP binding site [chemical binding]; other site 653045003949 Q-loop/lid; other site 653045003950 ABC transporter signature motif; other site 653045003951 Walker B; other site 653045003952 D-loop; other site 653045003953 H-loop/switch region; other site 653045003954 phosphodiesterase; Provisional; Region: PRK12704 653045003955 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 653045003956 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 653045003957 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045003958 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 653045003959 dimer interface [polypeptide binding]; other site 653045003960 substrate binding site [chemical binding]; other site 653045003961 metal binding site [ion binding]; metal-binding site 653045003962 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045003963 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 653045003964 dimer interface [polypeptide binding]; other site 653045003965 active site 653045003966 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 653045003967 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 653045003968 Walker A; other site 653045003969 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045003970 G4 box; other site 653045003971 G5 box; other site 653045003972 transcriptional regulator Hpr; Provisional; Region: PRK13777 653045003973 Helix-turn-helix domains; Region: HTH; cl00088 653045003974 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 653045003975 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 653045003976 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 653045003977 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 653045003978 Domain of unknown function DUF77; Region: DUF77; cl00307 653045003979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045003980 putative DNA binding site [nucleotide binding]; other site 653045003981 putative Zn2+ binding site [ion binding]; other site 653045003982 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045003983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045003984 Transcriptional regulators [Transcription]; Region: MarR; COG1846 653045003985 Helix-turn-helix domains; Region: HTH; cl00088 653045003986 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 653045003987 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 653045003988 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 653045003989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045003990 Helix-turn-helix domains; Region: HTH; cl00088 653045003991 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 653045003992 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 653045003993 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045003994 pyruvate kinase; Provisional; Region: PRK06247 653045003995 domain interfaces; other site 653045003996 active site 653045003997 acetate kinase; Region: ackA; TIGR00016 653045003998 Acetokinase family; Region: Acetate_kinase; cl01029 653045003999 phosphate acetyltransferase; Reviewed; Region: PRK05632 653045004000 DRTGG domain; Region: DRTGG; cl12147 653045004001 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 653045004002 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 653045004003 active site 653045004004 ADP/pyrophosphate binding site [chemical binding]; other site 653045004005 dimerization interface [polypeptide binding]; other site 653045004006 allosteric effector site; other site 653045004007 fructose-1,6-bisphosphate binding site; other site 653045004008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045004009 dimer interface [polypeptide binding]; other site 653045004010 conserved gate region; other site 653045004011 putative PBP binding loops; other site 653045004012 ABC-ATPase subunit interface; other site 653045004013 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045004014 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045004015 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045004016 Probable transposase; Region: OrfB_IS605; pfam01385 653045004017 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045004018 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 653045004019 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 653045004020 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 653045004021 DXD motif; other site 653045004022 hypothetical protein; Provisional; Region: PRK08317 653045004023 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045004024 S-adenosylmethionine binding site [chemical binding]; other site 653045004025 hypothetical protein; Provisional; Region: PRK06834 653045004026 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004027 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045004028 Helix-turn-helix domains; Region: HTH; cl00088 653045004029 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045004030 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045004031 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045004032 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045004033 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045004034 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045004035 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045004036 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045004037 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045004038 DNA binding residues [nucleotide binding] 653045004039 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 653045004040 nucleotide binding site/active site [active] 653045004041 HIT family signature motif; other site 653045004042 catalytic residue [active] 653045004043 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004044 NmrA-like family; Region: NmrA; pfam05368 653045004045 NAD(P) binding site [chemical binding]; other site 653045004046 active site 653045004047 Helix-turn-helix domains; Region: HTH; cl00088 653045004048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045004049 dimer interface [polypeptide binding]; other site 653045004050 conserved gate region; other site 653045004051 putative PBP binding loops; other site 653045004052 ABC-ATPase subunit interface; other site 653045004053 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045004054 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 653045004055 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 653045004056 active site 653045004057 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045004058 Helix-turn-helix domains; Region: HTH; cl00088 653045004059 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 653045004060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045004061 active site 653045004062 phosphorylation site [posttranslational modification] 653045004063 intermolecular recognition site; other site 653045004064 dimerization interface [polypeptide binding]; other site 653045004065 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045004066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045004067 ATP binding site [chemical binding]; other site 653045004068 Mg2+ binding site [ion binding]; other site 653045004069 G-X-G motif; other site 653045004070 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 653045004071 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 653045004072 Helix-turn-helix domains; Region: HTH; cl00088 653045004073 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045004074 AAA domain; Region: AAA_22; pfam13401 653045004075 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045004076 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045004077 binding surface 653045004078 TPR motif; other site 653045004079 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045004080 glycogen branching enzyme; Provisional; Region: PRK05402 653045004081 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 653045004082 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 653045004083 active site 653045004084 catalytic site [active] 653045004085 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 653045004086 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 653045004087 trehalose synthase; Region: treS_nterm; TIGR02456 653045004088 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 653045004089 active site 653045004090 catalytic site [active] 653045004091 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 653045004092 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 653045004093 active site 653045004094 catalytic site [active] 653045004095 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 653045004096 calcium binding site 2 [ion binding]; other site 653045004097 active site 653045004098 catalytic triad [active] 653045004099 calcium binding site 1 [ion binding]; other site 653045004100 Pectate lyase; Region: Pectate_lyase; pfam03211 653045004101 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 653045004102 metal binding site [ion binding]; metal-binding site 653045004103 active site 653045004104 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 653045004105 putative homodimer interface [polypeptide binding]; other site 653045004106 putative active site pocket [active] 653045004107 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 653045004108 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045004109 non-specific DNA binding site [nucleotide binding]; other site 653045004110 salt bridge; other site 653045004111 sequence-specific DNA binding site [nucleotide binding]; other site 653045004112 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045004113 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045004114 NAD(P) binding site [chemical binding]; other site 653045004115 catalytic residues [active] 653045004116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045004117 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 653045004118 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 653045004119 active site 653045004120 Zn binding site [ion binding]; other site 653045004121 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 653045004122 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 653045004123 active site 653045004124 Zn binding site [ion binding]; other site 653045004125 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 653045004126 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 653045004127 active site 653045004128 Zn binding site [ion binding]; other site 653045004129 Cadherin repeat-like domain; Region: CA_like; cl15786 653045004130 Proprotein convertase P-domain; Region: P_proprotein; pfam01483 653045004131 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045004132 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 653045004133 active site pocket [active] 653045004134 oxyanion hole [active] 653045004135 catalytic triad [active] 653045004136 active site nucleophile [active] 653045004137 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045004138 Helix-turn-helix domains; Region: HTH; cl00088 653045004139 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045004140 Protein of unknown function (DUF1177); Region: DUF1177; pfam06675 653045004141 OPT oligopeptide transporter protein; Region: OPT; cl14607 653045004142 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 653045004143 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045004144 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045004145 Helix-turn-helix domains; Region: HTH; cl00088 653045004146 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 653045004147 substrate binding site [chemical binding]; other site 653045004148 active site 653045004149 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045004150 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045004151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004152 Walker A/P-loop; other site 653045004153 ATP binding site [chemical binding]; other site 653045004154 Q-loop/lid; other site 653045004155 ABC transporter signature motif; other site 653045004156 Walker B; other site 653045004157 D-loop; other site 653045004158 H-loop/switch region; other site 653045004159 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045004160 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045004161 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004162 Walker A/P-loop; other site 653045004163 ATP binding site [chemical binding]; other site 653045004164 Q-loop/lid; other site 653045004165 ABC transporter signature motif; other site 653045004166 Walker B; other site 653045004167 D-loop; other site 653045004168 H-loop/switch region; other site 653045004169 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 653045004170 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 653045004171 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 653045004172 active site 653045004173 catalytic site [active] 653045004174 Bacterial Ig-like domain; Region: Big_5; cl01012 653045004175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 653045004176 enoyl-CoA hydratase; Provisional; Region: PRK05862 653045004177 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045004178 substrate binding site [chemical binding]; other site 653045004179 oxyanion hole (OAH) forming residues; other site 653045004180 trimer interface [polypeptide binding]; other site 653045004181 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045004182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045004183 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 653045004184 amidase catalytic site [active] 653045004185 Zn binding residues [ion binding]; other site 653045004186 substrate binding site [chemical binding]; other site 653045004187 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 653045004188 EF-hand domain pair; Region: EF_hand_5; pfam13499 653045004189 Ca2+ binding site [ion binding]; other site 653045004190 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 653045004191 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 653045004192 active site 653045004193 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045004194 non-specific DNA binding site [nucleotide binding]; other site 653045004195 salt bridge; other site 653045004196 sequence-specific DNA binding site [nucleotide binding]; other site 653045004197 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045004198 Protease prsW family; Region: PrsW-protease; cl15823 653045004199 RHS Repeat; Region: RHS_repeat; cl11982 653045004200 RHS Repeat; Region: RHS_repeat; cl11982 653045004201 RHS Repeat; Region: RHS_repeat; cl11982 653045004202 RHS Repeat; Region: RHS_repeat; cl11982 653045004203 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 653045004204 RHS Repeat; Region: RHS_repeat; cl11982 653045004205 RHS Repeat; Region: RHS_repeat; cl11982 653045004206 RHS Repeat; Region: RHS_repeat; cl11982 653045004207 RHS Repeat; Region: RHS_repeat; cl11982 653045004208 RHS Repeat; Region: RHS_repeat; cl11982 653045004209 RHS Repeat; Region: RHS_repeat; cl11982 653045004210 RHS Repeat; Region: RHS_repeat; cl11982 653045004211 RHS Repeat; Region: RHS_repeat; cl11982 653045004212 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 653045004213 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045004214 putative active site [active] 653045004215 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 653045004216 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045004217 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045004218 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045004219 Uncharacterized conserved protein [Function unknown]; Region: COG2128 653045004220 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045004221 DEAD-like helicases superfamily; Region: DEXDc; smart00487 653045004222 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 653045004223 ATP binding site [chemical binding]; other site 653045004224 Mg++ binding site [ion binding]; other site 653045004225 motif III; other site 653045004226 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045004227 nucleotide binding region [chemical binding]; other site 653045004228 ATP-binding site [chemical binding]; other site 653045004229 DbpA RNA binding domain; Region: DbpA; pfam03880 653045004230 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045004231 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 653045004232 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 653045004233 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 653045004234 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 653045004235 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 653045004236 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 653045004237 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 653045004238 dimer interface [polypeptide binding]; other site 653045004239 active site 653045004240 glycine-pyridoxal phosphate binding site [chemical binding]; other site 653045004241 folate binding site [chemical binding]; other site 653045004242 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 653045004243 lipoyl attachment site [posttranslational modification]; other site 653045004244 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 653045004245 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 653045004246 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 653045004247 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 653045004248 AAA domain; Region: AAA_33; pfam13671 653045004249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045004251 dimer interface [polypeptide binding]; other site 653045004252 conserved gate region; other site 653045004253 putative PBP binding loops; other site 653045004254 ABC-ATPase subunit interface; other site 653045004255 The substrate-binding domain of an oligopeptide binding protein (OppA2) from the biosynthesis pathway of the beta-lactamase inhibitor clavulanic acid contains the type 2 periplasmic binding fold; Region: PBP2_clavulanate_OppA2; cd08506 653045004256 peptide binding site [polypeptide binding]; other site 653045004257 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045004258 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045004259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045004260 dimer interface [polypeptide binding]; other site 653045004261 conserved gate region; other site 653045004262 ABC-ATPase subunit interface; other site 653045004263 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045004264 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045004265 Walker A/P-loop; other site 653045004266 ATP binding site [chemical binding]; other site 653045004267 Q-loop/lid; other site 653045004268 ABC transporter signature motif; other site 653045004269 Walker B; other site 653045004270 D-loop; other site 653045004271 H-loop/switch region; other site 653045004272 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045004273 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 653045004274 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045004275 Walker A/P-loop; other site 653045004276 ATP binding site [chemical binding]; other site 653045004277 Q-loop/lid; other site 653045004278 ABC transporter signature motif; other site 653045004279 Walker B; other site 653045004280 D-loop; other site 653045004281 H-loop/switch region; other site 653045004282 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045004283 Predicted membrane protein [Function unknown]; Region: COG2860 653045004284 UPF0126 domain; Region: UPF0126; pfam03458 653045004285 UPF0126 domain; Region: UPF0126; pfam03458 653045004286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045004287 dimerization interface [polypeptide binding]; other site 653045004288 putative DNA binding site [nucleotide binding]; other site 653045004289 putative Zn2+ binding site [ion binding]; other site 653045004290 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 653045004291 putative hydrophobic ligand binding site [chemical binding]; other site 653045004292 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045004293 hydrophobic ligand binding site; other site 653045004294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045004295 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045004296 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 653045004297 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045004298 catalytic residue [active] 653045004299 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 653045004300 amidase catalytic site [active] 653045004301 Zn binding residues [ion binding]; other site 653045004302 substrate binding site [chemical binding]; other site 653045004303 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045004304 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 653045004305 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 653045004306 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 653045004307 Methyltransferase domain; Region: Methyltransf_31; pfam13847 653045004308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045004309 S-adenosylmethionine binding site [chemical binding]; other site 653045004310 phosphoethanolamine N-methyltransferase; Region: PLN02336 653045004311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045004312 S-adenosylmethionine binding site [chemical binding]; other site 653045004313 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045004314 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045004315 DNA binding residues [nucleotide binding] 653045004316 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045004317 homodimer interface [polypeptide binding]; other site 653045004318 active site 653045004319 TDP-binding site; other site 653045004320 acceptor substrate-binding pocket; other site 653045004321 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 653045004322 glutathione synthetase; Provisional; Region: PRK05246 653045004323 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045004324 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045004325 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045004326 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045004327 salt bridge; other site 653045004328 non-specific DNA binding site [nucleotide binding]; other site 653045004329 sequence-specific DNA binding site [nucleotide binding]; other site 653045004330 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045004331 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045004332 classical (c) SDRs; Region: SDR_c; cd05233 653045004333 NAD(P) binding site [chemical binding]; other site 653045004334 active site 653045004335 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310 653045004336 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 653045004337 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 653045004338 nucleotide binding pocket [chemical binding]; other site 653045004339 K-X-D-G motif; other site 653045004340 catalytic site [active] 653045004341 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 653045004342 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 653045004343 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 653045004344 Dimer interface [polypeptide binding]; other site 653045004345 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 653045004346 metal binding site [ion binding]; metal-binding site 653045004347 active site 653045004348 I-site; other site 653045004349 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 653045004350 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 653045004351 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 653045004352 Amidase; Region: Amidase; cl11426 653045004353 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 653045004354 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 653045004355 GatB domain; Region: GatB_Yqey; cl11497 653045004356 Uncharacterized conserved protein [Function unknown]; Region: COG5476 653045004357 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 653045004358 MlrC C-terminus; Region: MlrC_C; pfam07171 653045004359 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045004360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004361 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 653045004362 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045004363 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045004364 DNA binding residues [nucleotide binding] 653045004365 dimerization interface [polypeptide binding]; other site 653045004366 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 653045004367 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 653045004368 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045004369 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045004370 active site 653045004371 catalytic tetrad [active] 653045004372 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004373 PAS domain S-box; Region: sensory_box; TIGR00229 653045004374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045004375 putative active site [active] 653045004376 heme pocket [chemical binding]; other site 653045004377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 653045004378 metal binding site [ion binding]; metal-binding site 653045004379 active site 653045004380 I-site; other site 653045004381 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 653045004382 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 653045004383 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 653045004384 PYR/PP interface [polypeptide binding]; other site 653045004385 dimer interface [polypeptide binding]; other site 653045004386 TPP binding site [chemical binding]; other site 653045004387 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045004388 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 653045004389 TPP-binding site [chemical binding]; other site 653045004390 dimer interface [polypeptide binding]; other site 653045004391 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 653045004392 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 653045004393 putative valine binding site [chemical binding]; other site 653045004394 dimer interface [polypeptide binding]; other site 653045004395 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 653045004396 ketol-acid reductoisomerase; Provisional; Region: PRK05479 653045004397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004398 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 653045004399 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 653045004400 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004401 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 653045004402 putative L-serine binding site [chemical binding]; other site 653045004403 Helix-turn-helix domains; Region: HTH; cl00088 653045004404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045004405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045004406 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 653045004407 putative catalytic residues [active] 653045004408 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 653045004409 tetracycline repressor protein TetR; Provisional; Region: PRK13756 653045004410 Helix-turn-helix domains; Region: HTH; cl00088 653045004411 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045004412 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045004413 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045004414 putative active site [active] 653045004415 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 653045004416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045004417 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 653045004418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045004419 Helix-turn-helix domains; Region: HTH; cl00088 653045004420 Helix-turn-helix domains; Region: HTH; cl00088 653045004421 Proline dehydrogenase; Region: Pro_dh; cl03282 653045004422 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045004423 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045004424 NAD(P) binding site [chemical binding]; other site 653045004425 catalytic residues [active] 653045004426 PhoD-like phosphatase; Region: PhoD; pfam09423 653045004427 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045004428 active site 653045004429 metal binding site [ion binding]; metal-binding site 653045004430 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 653045004431 tartrate dehydrogenase; Provisional; Region: PRK08194 653045004432 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 653045004433 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 653045004434 homodimer interface [polypeptide binding]; other site 653045004435 substrate-cofactor binding pocket; other site 653045004436 catalytic residue [active] 653045004437 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 653045004438 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 653045004439 active site 653045004440 catalytic residues [active] 653045004441 metal binding site [ion binding]; metal-binding site 653045004442 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 653045004443 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 653045004444 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045004445 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045004446 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045004447 G2 box; other site 653045004448 Switch I region; other site 653045004449 G3 box; other site 653045004450 Switch II region; other site 653045004451 GTP/Mg2+ binding site [chemical binding]; other site 653045004452 G4 box; other site 653045004453 G5 box; other site 653045004454 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045004455 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045004456 Nitrate and nitrite sensing; Region: NIT; pfam08376 653045004457 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045004458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045004459 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045004460 ATP binding site [chemical binding]; other site 653045004461 Mg2+ binding site [ion binding]; other site 653045004462 G-X-G motif; other site 653045004463 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 653045004464 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045004465 G2 box; other site 653045004466 Switch I region; other site 653045004467 G3 box; other site 653045004468 Switch II region; other site 653045004469 GTP/Mg2+ binding site [chemical binding]; other site 653045004470 G4 box; other site 653045004471 G5 box; other site 653045004472 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045004473 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045004474 Nitrate and nitrite sensing; Region: NIT; pfam08376 653045004475 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045004476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045004477 ATP binding site [chemical binding]; other site 653045004478 Mg2+ binding site [ion binding]; other site 653045004479 G-X-G motif; other site 653045004480 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 653045004481 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 653045004482 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045004483 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 653045004484 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 653045004485 HIGH motif; other site 653045004486 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 653045004487 active site 653045004488 KMSKS motif; other site 653045004489 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045004490 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045004491 DNA binding residues [nucleotide binding] 653045004492 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045004493 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045004494 Helix-turn-helix domains; Region: HTH; cl00088 653045004495 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045004496 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 653045004497 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 653045004498 substrate binding site [chemical binding]; other site 653045004499 ligand binding site [chemical binding]; other site 653045004500 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 653045004501 substrate binding site [chemical binding]; other site 653045004502 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 653045004503 IHF dimer interface [polypeptide binding]; other site 653045004504 IHF - DNA interface [nucleotide binding]; other site 653045004505 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045004506 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 653045004507 putative acyl-acceptor binding pocket; other site 653045004508 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 653045004509 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004510 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 653045004511 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 653045004512 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 653045004513 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045004514 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 653045004515 Helix-turn-helix domains; Region: HTH; cl00088 653045004516 thiamine monophosphate kinase; Provisional; Region: PRK05731 653045004517 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 653045004518 ATP binding site [chemical binding]; other site 653045004519 dimerization interface [polypeptide binding]; other site 653045004520 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 653045004521 dimer interface [polypeptide binding]; other site 653045004522 substrate binding site [chemical binding]; other site 653045004523 ATP binding site [chemical binding]; other site 653045004524 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 653045004525 DAK2 domain; Region: Dak2; cl03685 653045004526 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 653045004527 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 653045004528 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 653045004529 generic binding surface II; other site 653045004530 ssDNA binding site; other site 653045004531 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045004532 ATP binding site [chemical binding]; other site 653045004533 putative Mg++ binding site [ion binding]; other site 653045004534 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045004535 nucleotide binding region [chemical binding]; other site 653045004536 ATP-binding site [chemical binding]; other site 653045004537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045004538 S-adenosylmethionine binding site [chemical binding]; other site 653045004539 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 653045004540 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 653045004541 active site 653045004542 (T/H)XGH motif; other site 653045004543 Plant ATP synthase F0; Region: YMF19; cl07975 653045004544 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 653045004545 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 653045004546 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 653045004547 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 653045004548 dimerization interface [polypeptide binding]; other site 653045004549 active site 653045004550 metal binding site [ion binding]; metal-binding site 653045004551 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 653045004552 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 653045004553 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 653045004554 DNA binding site [nucleotide binding] 653045004555 catalytic residue [active] 653045004556 H2TH interface [polypeptide binding]; other site 653045004557 putative catalytic residues [active] 653045004558 turnover-facilitating residue; other site 653045004559 intercalation triad [nucleotide binding]; other site 653045004560 8OG recognition residue [nucleotide binding]; other site 653045004561 putative reading head residues; other site 653045004562 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 653045004563 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 653045004564 Helix-turn-helix domains; Region: HTH; cl00088 653045004565 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 653045004566 Acylphosphatase; Region: Acylphosphatase; cl00551 653045004567 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 653045004568 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 653045004569 Walker A/P-loop; other site 653045004570 ATP binding site [chemical binding]; other site 653045004571 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 653045004572 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 653045004573 ABC transporter signature motif; other site 653045004574 Walker B; other site 653045004575 D-loop; other site 653045004576 H-loop/switch region; other site 653045004577 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 653045004578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045004579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045004580 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045004581 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 653045004582 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045004583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045004584 ATP binding site [chemical binding]; other site 653045004585 Mg2+ binding site [ion binding]; other site 653045004586 G-X-G motif; other site 653045004587 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045004588 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045004589 active site 653045004590 phosphorylation site [posttranslational modification] 653045004591 intermolecular recognition site; other site 653045004592 dimerization interface [polypeptide binding]; other site 653045004593 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045004594 DNA binding residues [nucleotide binding] 653045004595 dimerization interface [polypeptide binding]; other site 653045004596 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 653045004597 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 653045004598 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004599 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 653045004600 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 653045004601 Nitrogen regulatory protein P-II; Region: P-II; cl00412 653045004602 Nitrogen regulatory protein P-II; Region: P-II; smart00938 653045004603 PII uridylyl-transferase; Provisional; Region: PRK03381 653045004604 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 653045004605 metal binding triad; other site 653045004606 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 653045004607 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045004608 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 653045004609 signal recognition particle protein; Provisional; Region: PRK10867 653045004610 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 653045004611 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 653045004612 P loop; other site 653045004613 GTP binding site [chemical binding]; other site 653045004614 Signal peptide binding domain; Region: SRP_SPB; pfam02978 653045004615 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_arch_euk; cd00778 653045004616 dimer interface [polypeptide binding]; other site 653045004617 motif 1; other site 653045004618 active site 653045004619 motif 2; other site 653045004620 motif 3; other site 653045004621 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 653045004622 anticodon binding site; other site 653045004623 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 653045004624 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 653045004625 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 653045004626 RimM N-terminal domain; Region: RimM; pfam01782 653045004627 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 653045004628 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 653045004629 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 653045004630 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 653045004631 Catalytic site [active] 653045004632 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 653045004633 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 653045004634 Catalytic site [active] 653045004635 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 653045004636 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 653045004637 Catalytic site [active] 653045004638 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 653045004639 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 653045004640 Catalytic site [active] 653045004641 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 653045004642 nudix motif; other site 653045004643 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 653045004644 Restriction endonuclease; Region: Mrr_cat; cl00516 653045004645 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 653045004646 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 653045004647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004648 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 653045004649 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 653045004650 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 653045004651 RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288 653045004652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045004653 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045004654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045004655 DNA binding residues [nucleotide binding] 653045004656 Helix-turn-helix domains; Region: HTH; cl00088 653045004657 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 653045004658 rRNA interaction site [nucleotide binding]; other site 653045004659 S8 interaction site; other site 653045004660 putative laminin-1 binding site; other site 653045004661 elongation factor Ts; Provisional; Region: tsf; PRK09377 653045004662 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 653045004663 Elongation factor TS; Region: EF_TS; pfam00889 653045004664 Elongation factor TS; Region: EF_TS; pfam00889 653045004665 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 653045004666 putative nucleotide binding site [chemical binding]; other site 653045004667 uridine monophosphate binding site [chemical binding]; other site 653045004668 homohexameric interface [polypeptide binding]; other site 653045004669 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 653045004670 hinge region; other site 653045004671 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 653045004672 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045004673 active site 653045004674 DNA binding site [nucleotide binding] 653045004675 Int/Topo IB signature motif; other site 653045004676 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045004677 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 653045004678 Mobile element transfer protein; Region: SpdB; pfam05122 653045004679 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 653045004680 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004681 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045004682 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045004683 DNA-binding site [nucleotide binding]; DNA binding site 653045004684 UTRA domain; Region: UTRA; cl01230 653045004685 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 653045004686 putative active site [active] 653045004687 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 653045004688 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045004689 FeS/SAM binding site; other site 653045004690 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 653045004691 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045004692 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 653045004693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045004694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045004695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045004696 dimer interface [polypeptide binding]; other site 653045004697 conserved gate region; other site 653045004698 putative PBP binding loops; other site 653045004699 ABC-ATPase subunit interface; other site 653045004700 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 653045004701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004702 Walker A/P-loop; other site 653045004703 ATP binding site [chemical binding]; other site 653045004704 Q-loop/lid; other site 653045004705 ABC transporter signature motif; other site 653045004706 Walker B; other site 653045004707 D-loop; other site 653045004708 H-loop/switch region; other site 653045004709 TOBE domain; Region: TOBE_2; cl01440 653045004710 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 653045004711 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045004712 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045004713 Walker A/P-loop; other site 653045004714 ATP binding site [chemical binding]; other site 653045004715 Q-loop/lid; other site 653045004716 ABC transporter signature motif; other site 653045004717 Walker B; other site 653045004718 D-loop; other site 653045004719 H-loop/switch region; other site 653045004720 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 653045004721 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 653045004722 PYR/PP interface [polypeptide binding]; other site 653045004723 dimer interface [polypeptide binding]; other site 653045004724 TPP binding site [chemical binding]; other site 653045004725 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045004726 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 653045004727 TPP-binding site [chemical binding]; other site 653045004728 Sodium:solute symporter family; Region: SSF; cl00456 653045004729 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 653045004730 Helix-turn-helix domains; Region: HTH; cl00088 653045004731 hypothetical protein; Provisional; Region: PRK06541 653045004732 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045004733 inhibitor-cofactor binding pocket; inhibition site 653045004734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045004735 catalytic residue [active] 653045004736 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045004737 Helix-turn-helix domains; Region: HTH; cl00088 653045004738 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045004739 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 653045004740 tetrameric interface [polypeptide binding]; other site 653045004741 NAD binding site [chemical binding]; other site 653045004742 catalytic residues [active] 653045004743 substrate binding site [chemical binding]; other site 653045004744 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 653045004745 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 653045004746 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 653045004747 active site 653045004748 catalytic site [active] 653045004749 metal binding site [ion binding]; metal-binding site 653045004750 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 653045004751 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045004752 active site 653045004753 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045004754 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 653045004755 tetrameric interface [polypeptide binding]; other site 653045004756 NAD binding site [chemical binding]; other site 653045004757 catalytic residues [active] 653045004758 substrate binding site [chemical binding]; other site 653045004759 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 653045004760 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045004761 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 653045004762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004763 Walker A/P-loop; other site 653045004764 ATP binding site [chemical binding]; other site 653045004765 Q-loop/lid; other site 653045004766 ABC transporter signature motif; other site 653045004767 Walker B; other site 653045004768 D-loop; other site 653045004769 H-loop/switch region; other site 653045004770 TOBE domain; Region: TOBE_2; cl01440 653045004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045004772 dimer interface [polypeptide binding]; other site 653045004773 conserved gate region; other site 653045004774 putative PBP binding loops; other site 653045004775 ABC-ATPase subunit interface; other site 653045004776 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 653045004777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045004778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004779 FAD dependent oxidoreductase; Region: DAO; pfam01266 653045004780 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 653045004781 active site 653045004782 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 653045004783 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045004784 inhibitor-cofactor binding pocket; inhibition site 653045004785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045004786 catalytic residue [active] 653045004787 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 653045004788 Helix-turn-helix domains; Region: HTH; cl00088 653045004789 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045004790 Aldehyde dehydrogenase family 21A1-like; Region: ALDH_F21_RNP123; cd07147 653045004791 NAD(P) binding site [chemical binding]; other site 653045004792 catalytic residues [active] 653045004793 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045004794 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 653045004795 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 653045004796 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 653045004797 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045004798 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 653045004799 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045004800 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 653045004801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045004802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045004804 dimer interface [polypeptide binding]; other site 653045004805 conserved gate region; other site 653045004806 putative PBP binding loops; other site 653045004807 ABC-ATPase subunit interface; other site 653045004808 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 653045004809 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 653045004810 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 653045004811 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 653045004812 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 653045004813 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045004814 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045004815 DNA binding site [nucleotide binding] 653045004816 domain linker motif; other site 653045004817 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045004818 dimerization interface [polypeptide binding]; other site 653045004819 ligand binding site [chemical binding]; other site 653045004820 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045004821 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045004822 active site 653045004823 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 653045004824 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 653045004825 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 653045004826 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 653045004827 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 653045004828 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 653045004829 active site 653045004830 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 653045004831 protein binding site [polypeptide binding]; other site 653045004832 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 653045004833 putative substrate binding region [chemical binding]; other site 653045004834 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 653045004835 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 653045004836 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 653045004837 Predicted acetyltransferase [General function prediction only]; Region: COG3393 653045004838 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 653045004839 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045004840 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045004841 prolyl-tRNA synthetase; Provisional; Region: PRK09194 653045004842 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 653045004843 motif 1; other site 653045004844 dimer interface [polypeptide binding]; other site 653045004845 active site 653045004846 motif 2; other site 653045004847 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 653045004848 putative deacylase active site [active] 653045004849 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 653045004850 active site 653045004851 motif 3; other site 653045004852 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 653045004853 anticodon binding site; other site 653045004854 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045004855 ribosome maturation protein RimP; Reviewed; Region: PRK00092 653045004856 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 653045004857 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 653045004858 Hfq - Hfq interaction site; other site 653045004859 Sm1 motif; other site 653045004860 D1 - D2 interaction site; other site 653045004861 D3 - B interaction site; other site 653045004862 RNA binding pocket [nucleotide binding]; other site 653045004863 Sm2 motif; other site 653045004864 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 653045004865 NusA N-terminal domain; Region: NusA_N; pfam08529 653045004866 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 653045004867 RNA binding site [nucleotide binding]; other site 653045004868 homodimer interface [polypeptide binding]; other site 653045004869 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 653045004870 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 653045004871 G-X-X-G motif; other site 653045004872 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 653045004873 putative RNA binding cleft [nucleotide binding]; other site 653045004874 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 653045004875 translation initiation factor IF-2; Region: IF-2; TIGR00487 653045004876 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 653045004877 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 653045004878 G1 box; other site 653045004879 putative GEF interaction site [polypeptide binding]; other site 653045004880 GTP/Mg2+ binding site [chemical binding]; other site 653045004881 Switch I region; other site 653045004882 G2 box; other site 653045004883 G3 box; other site 653045004884 Switch II region; other site 653045004885 G4 box; other site 653045004886 G5 box; other site 653045004887 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 653045004888 Translation-initiation factor 2; Region: IF-2; pfam11987 653045004889 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 653045004890 Protein of unknown function (DUF503); Region: DUF503; cl00669 653045004891 Ribosome-binding factor A; Region: RBFA; cl00542 653045004892 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 653045004893 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 653045004894 RNA binding site [nucleotide binding]; other site 653045004895 active site 653045004896 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 653045004897 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 653045004898 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 653045004899 active site 653045004900 Riboflavin kinase; Region: Flavokinase; cl03312 653045004901 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 653045004902 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045004903 Protein of unknown function (DUF2984); Region: DUF2984; cl12752 653045004904 Protein of unknown function (DUF690); Region: DUF690; cl04939 653045004905 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 653045004906 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 653045004907 active site 653045004908 catalytic residues [active] 653045004909 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 653045004910 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 653045004911 active site 653045004912 catalytic residues [active] 653045004913 Proteins of 100 residues with WXG; Region: WXG100; cl02005 653045004914 Proteins of 100 residues with WXG; Region: WXG100; cl02005 653045004915 Winged helix-turn helix; Region: HTH_29; pfam13551 653045004916 Helix-turn-helix domains; Region: HTH; cl00088 653045004917 Winged helix-turn helix; Region: HTH_33; pfam13592 653045004918 Integrase core domain; Region: rve; cl01316 653045004919 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 653045004920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004921 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 653045004922 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004923 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045004924 Ubiquitin-like proteins; Region: UBQ; cl00155 653045004925 PQQ-like domain; Region: PQQ_2; pfam13360 653045004926 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045004927 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045004928 active site 653045004929 ATP binding site [chemical binding]; other site 653045004930 substrate binding site [chemical binding]; other site 653045004931 activation loop (A-loop); other site 653045004932 outer membrane assembly lipoprotein YfgL; Region: assembly_YfgL; TIGR03300 653045004933 PQQ-like domain; Region: PQQ_2; pfam13360 653045004934 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045004935 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045004936 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045004937 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045004938 active site 653045004939 ATP binding site [chemical binding]; other site 653045004940 substrate binding site [chemical binding]; other site 653045004941 activation loop (A-loop); other site 653045004942 PQQ-like domain; Region: PQQ_2; pfam13360 653045004943 PQQ-like domain; Region: PQQ_2; pfam13360 653045004944 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045004945 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045004946 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045004947 active site 653045004948 ATP binding site [chemical binding]; other site 653045004949 substrate binding site [chemical binding]; other site 653045004950 activation loop (A-loop); other site 653045004951 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045004952 active site 653045004953 PQQ-like domain; Region: PQQ_2; pfam13360 653045004954 Trp docking motif [polypeptide binding]; other site 653045004955 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 653045004956 16S/18S rRNA binding site [nucleotide binding]; other site 653045004957 S13e-L30e interaction site [polypeptide binding]; other site 653045004958 25S rRNA binding site [nucleotide binding]; other site 653045004959 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 653045004960 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 653045004961 oligomer interface [polypeptide binding]; other site 653045004962 RNA binding site [nucleotide binding]; other site 653045004963 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 653045004964 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 653045004965 RNase E interface [polypeptide binding]; other site 653045004966 trimer interface [polypeptide binding]; other site 653045004967 active site 653045004968 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 653045004969 putative nucleic acid binding region [nucleotide binding]; other site 653045004970 G-X-X-G motif; other site 653045004971 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 653045004972 RNA binding site [nucleotide binding]; other site 653045004973 domain interface; other site 653045004974 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 653045004975 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 653045004976 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 653045004977 dihydrodipicolinate reductase; Provisional; Region: PRK00048 653045004978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045004979 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 653045004980 Thymidylate synthase complementing protein; Region: Thy1; cl03630 653045004981 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 653045004982 dihydrodipicolinate synthase; Region: dapA; TIGR00674 653045004983 dimer interface [polypeptide binding]; other site 653045004984 active site 653045004985 catalytic residue [active] 653045004986 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 653045004987 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045004988 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 653045004989 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045004990 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045004991 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045004992 PAS fold; Region: PAS_4; pfam08448 653045004993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045004994 putative active site [active] 653045004995 heme pocket [chemical binding]; other site 653045004996 GAF domain; Region: GAF; cl15785 653045004997 GAF domain; Region: GAF_2; pfam13185 653045004998 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045004999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045005000 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 653045005001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045005002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045005003 dimerization interface [polypeptide binding]; other site 653045005004 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045005005 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045005006 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045005007 dimerization interface [polypeptide binding]; other site 653045005008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045005009 dimerization interface [polypeptide binding]; other site 653045005010 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 653045005011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045005012 dimerization interface [polypeptide binding]; other site 653045005013 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045005014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045005015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045005016 GAF domain; Region: GAF_2; pfam13185 653045005017 GAF domain; Region: GAF; cl15785 653045005018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045005019 Protein of unknown function (DUF904); Region: DUF904; cl11531 653045005020 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 653045005021 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005022 ATP binding site [chemical binding]; other site 653045005023 Mg2+ binding site [ion binding]; other site 653045005024 G-X-G motif; other site 653045005025 Response regulator receiver domain; Region: Response_reg; pfam00072 653045005026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005027 active site 653045005028 phosphorylation site [posttranslational modification] 653045005029 intermolecular recognition site; other site 653045005030 dimerization interface [polypeptide binding]; other site 653045005031 Response regulator receiver domain; Region: Response_reg; pfam00072 653045005032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005033 active site 653045005034 phosphorylation site [posttranslational modification] 653045005035 intermolecular recognition site; other site 653045005036 dimerization interface [polypeptide binding]; other site 653045005037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005038 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 653045005039 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045005040 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 653045005041 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 653045005042 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 653045005043 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045005044 FeS/SAM binding site; other site 653045005045 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045005046 Competence-damaged protein; Region: CinA; cl00666 653045005047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045005048 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 653045005049 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 653045005050 dimerization interface [polypeptide binding]; other site 653045005051 DPS ferroxidase diiron center [ion binding]; other site 653045005052 ion pore; other site 653045005053 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 653045005054 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 653045005055 putative DNA binding site [nucleotide binding]; other site 653045005056 catalytic residue [active] 653045005057 putative H2TH interface [polypeptide binding]; other site 653045005058 putative catalytic residues [active] 653045005059 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 653045005060 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 653045005061 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045005062 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 653045005063 ATP binding site [chemical binding]; other site 653045005064 putative Mg++ binding site [ion binding]; other site 653045005065 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045005066 nucleotide binding region [chemical binding]; other site 653045005067 ATP-binding site [chemical binding]; other site 653045005068 DEAD/H associated; Region: DEAD_assoc; pfam08494 653045005069 Cupin domain; Region: Cupin_2; cl09118 653045005070 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045005071 AzlC protein; Region: AzlC; cl00570 653045005072 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 653045005073 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 653045005074 recombinase A; Provisional; Region: recA; PRK09354 653045005075 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 653045005076 hexamer interface [polypeptide binding]; other site 653045005077 Walker A motif; other site 653045005078 ATP binding site [chemical binding]; other site 653045005079 Walker B motif; other site 653045005080 RecX family; Region: RecX; cl00936 653045005081 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 653045005082 active site residue [active] 653045005083 Cysteine dioxygenase type I; Region: CDO_I; cl15835 653045005084 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 653045005085 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 653045005086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005087 dimer interface [polypeptide binding]; other site 653045005088 conserved gate region; other site 653045005089 putative PBP binding loops; other site 653045005090 ABC-ATPase subunit interface; other site 653045005091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005092 dimer interface [polypeptide binding]; other site 653045005093 putative PBP binding loops; other site 653045005094 ABC-ATPase subunit interface; other site 653045005095 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045005096 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045005097 substrate binding pocket [chemical binding]; other site 653045005098 membrane-bound complex binding site; other site 653045005099 hinge residues; other site 653045005100 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 653045005101 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 653045005102 Walker A/P-loop; other site 653045005103 ATP binding site [chemical binding]; other site 653045005104 Q-loop/lid; other site 653045005105 ABC transporter signature motif; other site 653045005106 Walker B; other site 653045005107 D-loop; other site 653045005108 H-loop/switch region; other site 653045005109 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045005110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005111 active site 653045005112 phosphorylation site [posttranslational modification] 653045005113 intermolecular recognition site; other site 653045005114 dimerization interface [polypeptide binding]; other site 653045005115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045005116 DNA binding site [nucleotide binding] 653045005117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045005118 dimerization interface [polypeptide binding]; other site 653045005119 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 653045005120 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005121 ATP binding site [chemical binding]; other site 653045005122 Mg2+ binding site [ion binding]; other site 653045005123 G-X-G motif; other site 653045005124 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045005125 S-adenosylmethionine binding site [chemical binding]; other site 653045005126 NMT1-like family; Region: NMT1_2; cl15260 653045005127 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 653045005128 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045005129 Helix-turn-helix domains; Region: HTH; cl00088 653045005130 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045005131 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 653045005132 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 653045005133 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045005134 FeS/SAM binding site; other site 653045005135 TRAM domain; Region: TRAM; cl01282 653045005136 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 653045005137 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 653045005138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005139 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 653045005140 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 653045005141 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 653045005142 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 653045005143 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 653045005144 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045005145 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 653045005146 synthetase active site [active] 653045005147 NTP binding site [chemical binding]; other site 653045005148 metal binding site [ion binding]; metal-binding site 653045005149 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 653045005150 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 653045005151 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 653045005152 Peptidase family M1; Region: Peptidase_M1; pfam01433 653045005153 Zn binding site [ion binding]; other site 653045005154 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 653045005155 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 653045005156 HflX GTPase family; Region: HflX; cd01878 653045005157 G1 box; other site 653045005158 GTP/Mg2+ binding site [chemical binding]; other site 653045005159 Switch I region; other site 653045005160 G2 box; other site 653045005161 G3 box; other site 653045005162 Switch II region; other site 653045005163 G4 box; other site 653045005164 G5 box; other site 653045005165 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045005166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045005167 inhibitor-cofactor binding pocket; inhibition site 653045005168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045005169 catalytic residue [active] 653045005170 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045005171 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 653045005172 IucA / IucC family; Region: IucA_IucC; pfam04183 653045005173 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 653045005174 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 653045005175 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 653045005176 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045005177 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 653045005178 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005179 Helix-turn-helix domains; Region: HTH; cl00088 653045005180 LexA repressor; Validated; Region: PRK00215 653045005181 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 653045005182 Catalytic site [active] 653045005183 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 653045005184 ATP cone domain; Region: ATP-cone; pfam03477 653045005185 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 653045005186 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 653045005187 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 653045005188 active site 653045005189 dimer interface [polypeptide binding]; other site 653045005190 effector binding site; other site 653045005191 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 653045005192 TSCPD domain; Region: TSCPD; cl14834 653045005193 Helix-turn-helix domains; Region: HTH; cl00088 653045005194 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 653045005195 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005196 Walker A/P-loop; other site 653045005197 ATP binding site [chemical binding]; other site 653045005198 Q-loop/lid; other site 653045005199 ABC transporter signature motif; other site 653045005200 Walker B; other site 653045005201 D-loop; other site 653045005202 H-loop/switch region; other site 653045005203 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005204 Walker A/P-loop; other site 653045005205 ATP binding site [chemical binding]; other site 653045005206 Q-loop/lid; other site 653045005207 ABC transporter signature motif; other site 653045005208 Walker B; other site 653045005209 D-loop; other site 653045005210 H-loop/switch region; other site 653045005211 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045005212 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045005213 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045005214 catalytic core [active] 653045005215 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 653045005216 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 653045005217 RNA/DNA hybrid binding site [nucleotide binding]; other site 653045005218 active site 653045005219 hypothetical protein; Provisional; Region: yieM; PRK10997 653045005220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045005221 ATP binding site [chemical binding]; other site 653045005222 putative Mg++ binding site [ion binding]; other site 653045005223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045005224 nucleotide binding region [chemical binding]; other site 653045005225 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 653045005226 ATP-binding site [chemical binding]; other site 653045005227 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 653045005228 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045005229 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045005230 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 653045005231 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 653045005232 Walker A/P-loop; other site 653045005233 ATP binding site [chemical binding]; other site 653045005234 Q-loop/lid; other site 653045005235 ABC transporter signature motif; other site 653045005236 Walker B; other site 653045005237 D-loop; other site 653045005238 H-loop/switch region; other site 653045005239 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045005240 DNA-binding site [nucleotide binding]; DNA binding site 653045005241 FCD domain; Region: FCD; cl11656 653045005242 RNA polymerase sigma factor; Provisional; Region: PRK05901 653045005243 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 653045005244 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 653045005245 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045005246 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045005247 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045005248 DNA binding residues [nucleotide binding] 653045005249 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 653045005250 cleavage site 653045005251 active site 653045005252 substrate binding sites [chemical binding]; other site 653045005253 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 653045005254 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005255 ATP binding site [chemical binding]; other site 653045005256 Mg2+ binding site [ion binding]; other site 653045005257 G-X-G motif; other site 653045005258 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 653045005259 anchoring element; other site 653045005260 dimer interface [polypeptide binding]; other site 653045005261 ATP binding site [chemical binding]; other site 653045005262 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 653045005263 active site 653045005264 metal binding site [ion binding]; metal-binding site 653045005265 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 653045005266 Protein of unknown function, DUF485; Region: DUF485; cl01231 653045005267 Sodium:solute symporter family; Region: SSF; cl00456 653045005268 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 653045005269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005270 active site 653045005271 phosphorylation site [posttranslational modification] 653045005272 intermolecular recognition site; other site 653045005273 dimerization interface [polypeptide binding]; other site 653045005274 Helix-turn-helix domains; Region: HTH; cl00088 653045005275 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045005276 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045005277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005278 ATP binding site [chemical binding]; other site 653045005279 Mg2+ binding site [ion binding]; other site 653045005280 G-X-G motif; other site 653045005281 TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062 653045005282 putative dimer interface [polypeptide binding]; other site 653045005283 putative [2Fe-2S] cluster binding site [ion binding]; other site 653045005284 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 653045005285 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 653045005286 CAP-like domain; other site 653045005287 active site 653045005288 primary dimer interface [polypeptide binding]; other site 653045005289 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 653045005290 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 653045005291 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 653045005292 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 653045005293 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 653045005294 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 653045005295 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 653045005296 Peptidase family M23; Region: Peptidase_M23; pfam01551 653045005297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045005298 DNA-binding site [nucleotide binding]; DNA binding site 653045005299 FCD domain; Region: FCD; cl11656 653045005300 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 653045005301 dimerization domain swap beta strand [polypeptide binding]; other site 653045005302 regulatory protein interface [polypeptide binding]; other site 653045005303 active site 653045005304 regulatory phosphorylation site [posttranslational modification]; other site 653045005305 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 653045005306 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045005307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005308 CoA-ligase; Region: Ligase_CoA; cl02894 653045005309 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045005310 Sulfatase; Region: Sulfatase; cl10460 653045005311 thymidine kinase; Provisional; Region: PRK04296 653045005312 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045005313 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045005314 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045005315 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 653045005316 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 653045005317 active site residue [active] 653045005318 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 653045005319 active site residue [active] 653045005320 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 653045005321 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 653045005322 FAD binding domain; Region: FAD_binding_4; pfam01565 653045005323 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 653045005324 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045005325 ferrochelatase; Reviewed; Region: hemH; PRK00035 653045005326 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 653045005327 C-terminal domain interface [polypeptide binding]; other site 653045005328 active site 653045005329 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 653045005330 active site 653045005331 N-terminal domain interface [polypeptide binding]; other site 653045005332 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 653045005333 active site 653045005334 dimerization interface [polypeptide binding]; other site 653045005335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045005336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005337 active site 653045005338 phosphorylation site [posttranslational modification] 653045005339 intermolecular recognition site; other site 653045005340 dimerization interface [polypeptide binding]; other site 653045005341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045005342 DNA binding site [nucleotide binding] 653045005343 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045005344 dimerization interface [polypeptide binding]; other site 653045005345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045005346 dimer interface [polypeptide binding]; other site 653045005347 phosphorylation site [posttranslational modification] 653045005348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005349 ATP binding site [chemical binding]; other site 653045005350 Mg2+ binding site [ion binding]; other site 653045005351 G-X-G motif; other site 653045005352 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 653045005353 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 653045005354 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045005355 active site 2 [active] 653045005356 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 653045005357 trimer interface [polypeptide binding]; other site 653045005358 active site 653045005359 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 653045005360 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 653045005361 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 653045005362 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 653045005363 Ligand Binding Site [chemical binding]; other site 653045005364 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045005365 dimer interface [polypeptide binding]; other site 653045005366 phosphorylation site [posttranslational modification] 653045005367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005368 ATP binding site [chemical binding]; other site 653045005369 Mg2+ binding site [ion binding]; other site 653045005370 G-X-G motif; other site 653045005371 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 653045005372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005373 active site 653045005374 phosphorylation site [posttranslational modification] 653045005375 intermolecular recognition site; other site 653045005376 dimerization interface [polypeptide binding]; other site 653045005377 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045005378 DNA binding site [nucleotide binding] 653045005379 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 653045005380 ssDNA binding site; other site 653045005381 generic binding surface II; other site 653045005382 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 653045005383 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 653045005384 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005385 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 653045005386 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 653045005387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005388 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 653045005389 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045005390 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045005391 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045005392 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045005393 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 653045005394 G1 box; other site 653045005395 GTP/Mg2+ binding site [chemical binding]; other site 653045005396 G2 box; other site 653045005397 Switch I region; other site 653045005398 G3 box; other site 653045005399 Switch II region; other site 653045005400 G4 box; other site 653045005401 G5 box; other site 653045005402 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045005403 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045005404 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 653045005405 K+ potassium transporter; Region: K_trans; cl15781 653045005406 TRAM domain; Region: TRAM; cl01282 653045005407 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 653045005408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045005409 S-adenosylmethionine binding site [chemical binding]; other site 653045005410 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045005411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045005412 dimer interface [polypeptide binding]; other site 653045005413 phosphorylation site [posttranslational modification] 653045005414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005415 Mg2+ binding site [ion binding]; other site 653045005416 G-X-G motif; other site 653045005417 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045005418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005419 active site 653045005420 phosphorylation site [posttranslational modification] 653045005421 intermolecular recognition site; other site 653045005422 dimerization interface [polypeptide binding]; other site 653045005423 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045005424 DNA binding site [nucleotide binding] 653045005425 Peptidase family M48; Region: Peptidase_M48; cl12018 653045005426 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045005427 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 653045005428 Walker A/P-loop; other site 653045005429 ATP binding site [chemical binding]; other site 653045005430 Q-loop/lid; other site 653045005431 ABC transporter signature motif; other site 653045005432 Walker B; other site 653045005433 D-loop; other site 653045005434 H-loop/switch region; other site 653045005435 Histidine kinase; Region: HisKA_3; pfam07730 653045005436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005437 ATP binding site [chemical binding]; other site 653045005438 Mg2+ binding site [ion binding]; other site 653045005439 G-X-G motif; other site 653045005440 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045005441 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005442 active site 653045005443 phosphorylation site [posttranslational modification] 653045005444 intermolecular recognition site; other site 653045005445 dimerization interface [polypeptide binding]; other site 653045005446 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045005447 DNA binding residues [nucleotide binding] 653045005448 dimerization interface [polypeptide binding]; other site 653045005449 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 653045005450 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045005451 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045005452 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045005453 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045005454 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045005455 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045005456 DNA binding site [nucleotide binding] 653045005457 domain linker motif; other site 653045005458 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045005459 ligand binding site [chemical binding]; other site 653045005460 dimerization interface [polypeptide binding]; other site 653045005461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045005462 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045005463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005464 dimer interface [polypeptide binding]; other site 653045005465 conserved gate region; other site 653045005466 putative PBP binding loops; other site 653045005467 ABC-ATPase subunit interface; other site 653045005468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005469 dimer interface [polypeptide binding]; other site 653045005470 conserved gate region; other site 653045005471 putative PBP binding loops; other site 653045005472 ABC-ATPase subunit interface; other site 653045005473 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 653045005474 active site 653045005475 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005476 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045005477 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 653045005478 active site 653045005479 catalytic site [active] 653045005480 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045005481 AAA domain; Region: AAA_23; pfam13476 653045005482 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 653045005483 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045005484 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 653045005485 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 653045005486 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 653045005487 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 653045005488 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045005489 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 653045005490 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005491 Bacillus subtilis PrpE and related proteins, metallophosphatase domain; Region: MPP_PrpE; cd07423 653045005492 active site 653045005493 metal binding site [ion binding]; metal-binding site 653045005494 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045005495 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045005496 conserved cys residue [active] 653045005497 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045005498 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045005499 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045005500 putative substrate translocation pore; other site 653045005501 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045005502 ligand binding site [chemical binding]; other site 653045005503 flexible hinge region; other site 653045005504 Helix-turn-helix domains; Region: HTH; cl00088 653045005505 Amidinotransferase; Region: Amidinotransf; cl12043 653045005506 ornithine carbamoyltransferase; Validated; Region: PRK02102 653045005507 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 653045005508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005509 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045005510 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045005511 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 653045005512 substrate binding site [chemical binding]; other site 653045005513 ATP binding site [chemical binding]; other site 653045005514 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 653045005515 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 653045005516 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 653045005517 active site 653045005518 intersubunit interface [polypeptide binding]; other site 653045005519 catalytic residue [active] 653045005520 galactonate dehydratase; Provisional; Region: PRK14017 653045005521 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045005522 metal binding site [ion binding]; metal-binding site 653045005523 substrate binding pocket [chemical binding]; other site 653045005524 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045005525 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045005526 DNA-binding site [nucleotide binding]; DNA binding site 653045005527 FCD domain; Region: FCD; cl11656 653045005528 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045005529 classical (c) SDRs; Region: SDR_c; cd05233 653045005530 NAD(P) binding site [chemical binding]; other site 653045005531 active site 653045005532 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045005533 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045005534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005535 dimer interface [polypeptide binding]; other site 653045005536 putative PBP binding loops; other site 653045005537 ABC-ATPase subunit interface; other site 653045005538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005539 putative PBP binding loops; other site 653045005540 dimer interface [polypeptide binding]; other site 653045005541 ABC-ATPase subunit interface; other site 653045005542 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045005543 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045005544 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045005545 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 653045005546 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005547 NAD(P) binding site [chemical binding]; other site 653045005548 active site 653045005549 short chain dehydrogenase; Provisional; Region: PRK06180 653045005550 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045005551 NADP binding site [chemical binding]; other site 653045005552 active site 653045005553 steroid binding site; other site 653045005554 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045005555 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045005556 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 653045005557 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045005558 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045005559 Helix-turn-helix domains; Region: HTH; cl00088 653045005560 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 653045005561 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045005562 putative NAD(P) binding site [chemical binding]; other site 653045005563 Helix-turn-helix domains; Region: HTH; cl00088 653045005564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005565 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045005566 Helix-turn-helix domains; Region: HTH; cl00088 653045005567 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045005568 dimerization interface [polypeptide binding]; other site 653045005569 multidrug resistance protein MdtH; Provisional; Region: PRK11646 653045005570 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 653045005571 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 653045005572 dimer interface [polypeptide binding]; other site 653045005573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045005574 catalytic residue [active] 653045005575 Predicted permeases [General function prediction only]; Region: COG0701 653045005576 Predicted permease; Region: DUF318; pfam03773 653045005577 Domain of unknown function (DUF305); Region: DUF305; cl15795 653045005578 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045005579 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045005580 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045005581 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045005582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045005583 non-specific DNA binding site [nucleotide binding]; other site 653045005584 salt bridge; other site 653045005585 sequence-specific DNA binding site [nucleotide binding]; other site 653045005586 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 653045005587 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats with a...; Region: EPT_RTPC-like; cl00288 653045005588 putative active site [active] 653045005589 Helix-turn-helix domains; Region: HTH; cl00088 653045005590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045005591 dimerization interface [polypeptide binding]; other site 653045005592 Phosphotransferase enzyme family; Region: APH; pfam01636 653045005593 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045005594 active site 653045005595 substrate binding site [chemical binding]; other site 653045005596 ATP binding site [chemical binding]; other site 653045005597 aconitate hydratase; Validated; Region: PRK09277 653045005598 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 653045005599 substrate binding site [chemical binding]; other site 653045005600 ligand binding site [chemical binding]; other site 653045005601 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 653045005602 substrate binding site [chemical binding]; other site 653045005603 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045005604 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 653045005605 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 653045005606 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 653045005607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005608 NADH(P)-binding; Region: NAD_binding_10; pfam13460 653045005609 NAD(P) binding site [chemical binding]; other site 653045005610 active site 653045005611 Helix-turn-helix domains; Region: HTH; cl00088 653045005612 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045005613 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045005614 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 653045005615 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 653045005616 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 653045005617 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045005618 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 653045005619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005620 dimer interface [polypeptide binding]; other site 653045005621 putative PBP binding loops; other site 653045005622 ABC-ATPase subunit interface; other site 653045005623 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045005624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005625 dimer interface [polypeptide binding]; other site 653045005626 conserved gate region; other site 653045005627 putative PBP binding loops; other site 653045005628 ABC-ATPase subunit interface; other site 653045005629 Helix-turn-helix domains; Region: HTH; cl00088 653045005630 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045005631 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045005632 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 653045005633 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 653045005634 putative ligand binding site [chemical binding]; other site 653045005635 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005636 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 653045005637 Walker A/P-loop; other site 653045005638 ATP binding site [chemical binding]; other site 653045005639 Q-loop/lid; other site 653045005640 ABC transporter signature motif; other site 653045005641 Walker B; other site 653045005642 D-loop; other site 653045005643 H-loop/switch region; other site 653045005644 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 653045005645 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045005646 TM-ABC transporter signature motif; other site 653045005647 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12571 653045005648 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 653045005649 TPP-binding site; other site 653045005650 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 653045005651 PYR/PP interface [polypeptide binding]; other site 653045005652 dimer interface [polypeptide binding]; other site 653045005653 TPP binding site [chemical binding]; other site 653045005654 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 653045005655 amino acid transporter; Region: 2A0306; TIGR00909 653045005656 Spore germination protein; Region: Spore_permease; cl15802 653045005657 Spore germination protein; Region: Spore_permease; cl15802 653045005658 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 653045005659 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045005660 substrate binding site [chemical binding]; other site 653045005661 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 653045005662 oxyanion hole (OAH) forming residues; other site 653045005663 trimer interface [polypeptide binding]; other site 653045005664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005665 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045005666 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045005667 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 653045005668 dimer interface [polypeptide binding]; other site 653045005669 active site 653045005670 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 653045005671 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 653045005672 catalytic site [active] 653045005673 putative active site [active] 653045005674 putative substrate binding site [chemical binding]; other site 653045005675 HRDC domain; Region: HRDC; cl02578 653045005676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045005677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005678 active site 653045005679 phosphorylation site [posttranslational modification] 653045005680 intermolecular recognition site; other site 653045005681 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045005682 DNA binding residues [nucleotide binding] 653045005683 dimerization interface [polypeptide binding]; other site 653045005684 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 653045005685 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 653045005686 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 653045005687 substrate binding site [chemical binding]; other site 653045005688 active site 653045005689 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 653045005690 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045005691 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 653045005692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045005693 putative substrate translocation pore; other site 653045005694 D-galactonate transporter; Region: 2A0114; TIGR00893 653045005695 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045005696 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045005697 Helix-turn-helix domains; Region: HTH; cl00088 653045005698 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045005699 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 653045005700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005701 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 653045005702 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045005703 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045005704 Helix-turn-helix domains; Region: HTH; cl00088 653045005705 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045005706 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 653045005707 Helix-turn-helix domains; Region: HTH; cl00088 653045005708 Chlorite dismutase; Region: Chlor_dismutase; cl01280 653045005709 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045005710 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045005711 Protein of unknown function (DUF692); Region: DUF692; cl01263 653045005712 Transglycosylase; Region: Transgly; cl07896 653045005713 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 653045005714 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045005715 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 653045005716 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 653045005717 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 653045005718 Moco binding site; other site 653045005719 metal coordination site [ion binding]; other site 653045005720 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045005721 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045005722 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 653045005723 Ligand binding site; other site 653045005724 Putative Catalytic site; other site 653045005725 DXD motif; other site 653045005726 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045005727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045005728 active site 653045005729 phosphorylation site [posttranslational modification] 653045005730 intermolecular recognition site; other site 653045005731 dimerization interface [polypeptide binding]; other site 653045005732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045005733 DNA binding site [nucleotide binding] 653045005734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045005735 dimer interface [polypeptide binding]; other site 653045005736 phosphorylation site [posttranslational modification] 653045005737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045005738 ATP binding site [chemical binding]; other site 653045005739 Mg2+ binding site [ion binding]; other site 653045005740 G-X-G motif; other site 653045005741 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 653045005742 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005743 NAD(P) binding site [chemical binding]; other site 653045005744 active site 653045005745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045005746 MepB protein; Region: MepB; cl01985 653045005747 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cl00869 653045005748 dimer interface [polypeptide binding]; other site 653045005749 putative active site [active] 653045005750 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 653045005751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045005752 Walker A/P-loop; other site 653045005753 ATP binding site [chemical binding]; other site 653045005754 Q-loop/lid; other site 653045005755 ABC transporter signature motif; other site 653045005756 Walker B; other site 653045005757 D-loop; other site 653045005758 H-loop/switch region; other site 653045005759 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 653045005760 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045005761 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 653045005762 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 653045005763 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 653045005764 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 653045005765 methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841 653045005766 SelR domain; Region: SelR; pfam01641 653045005767 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 653045005768 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 653045005769 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 653045005770 catalytic site [active] 653045005771 active site 653045005772 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 653045005773 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045005774 Chitin binding domain; Region: Chitin_bind_3; cl03871 653045005775 Cellulose binding domain; Region: CBM_2; cl02709 653045005776 malto-oligosyltrehalose synthase; Region: trehalose_TreY; TIGR02401 653045005777 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 653045005778 active site 653045005779 catalytic site [active] 653045005780 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 653045005781 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045005782 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045005783 putative NAD(P) binding site [chemical binding]; other site 653045005784 Helix-turn-helix domains; Region: HTH; cl00088 653045005785 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 653045005786 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 653045005787 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 653045005788 active site 653045005789 catalytic site [active] 653045005790 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 653045005791 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 653045005792 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 653045005793 Walker A/P-loop; other site 653045005794 ATP binding site [chemical binding]; other site 653045005795 Q-loop/lid; other site 653045005796 ABC transporter signature motif; other site 653045005797 Walker B; other site 653045005798 D-loop; other site 653045005799 H-loop/switch region; other site 653045005800 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045005801 DNA-binding site [nucleotide binding]; DNA binding site 653045005802 FCD domain; Region: FCD; cl11656 653045005803 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 653045005804 active site 653045005805 catalytic site [active] 653045005806 substrate binding site [chemical binding]; other site 653045005807 TIGR03086 family protein; Region: TIGR03086 653045005808 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045005809 Phosphotransferase enzyme family; Region: APH; pfam01636 653045005810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005811 dimer interface [polypeptide binding]; other site 653045005812 conserved gate region; other site 653045005813 putative PBP binding loops; other site 653045005814 ABC-ATPase subunit interface; other site 653045005815 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045005816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005817 dimer interface [polypeptide binding]; other site 653045005818 conserved gate region; other site 653045005819 putative PBP binding loops; other site 653045005820 ABC-ATPase subunit interface; other site 653045005821 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045005822 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045005823 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045005824 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045005825 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 653045005826 Peptidase S8 family domain in ProteinaseK-like proteins; Region: Peptidases_S8_PCSK9_ProteinaseK_like; cd04077 653045005827 calcium binding site 2 [ion binding]; other site 653045005828 active site 653045005829 catalytic triad [active] 653045005830 calcium binding site 1 [ion binding]; other site 653045005831 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045005832 putative active site [active] 653045005833 Sporulation related domain; Region: SPOR; cl10051 653045005834 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 653045005835 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045005836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045005837 non-specific DNA binding site [nucleotide binding]; other site 653045005838 salt bridge; other site 653045005839 sequence-specific DNA binding site [nucleotide binding]; other site 653045005840 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 653045005841 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 653045005842 putative active site [active] 653045005843 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 653045005844 putative active site [active] 653045005845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045005846 dimer interface [polypeptide binding]; other site 653045005847 conserved gate region; other site 653045005848 putative PBP binding loops; other site 653045005849 ABC-ATPase subunit interface; other site 653045005850 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 653045005851 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045005852 Walker A/P-loop; other site 653045005853 ATP binding site [chemical binding]; other site 653045005854 Q-loop/lid; other site 653045005855 ABC transporter signature motif; other site 653045005856 Walker B; other site 653045005857 D-loop; other site 653045005858 H-loop/switch region; other site 653045005859 NMT1-like family; Region: NMT1_2; cl15260 653045005860 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 653045005861 sulfate adenylyltransferase, large subunit; Region: CysN; TIGR02034 653045005862 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 653045005863 CysD dimerization site [polypeptide binding]; other site 653045005864 G1 box; other site 653045005865 putative GEF interaction site [polypeptide binding]; other site 653045005866 GTP/Mg2+ binding site [chemical binding]; other site 653045005867 Switch I region; other site 653045005868 G2 box; other site 653045005869 G3 box; other site 653045005870 Switch II region; other site 653045005871 G4 box; other site 653045005872 G5 box; other site 653045005873 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 653045005874 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 653045005875 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 653045005876 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 653045005877 Active Sites [active] 653045005878 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 653045005879 ligand-binding site [chemical binding]; other site 653045005880 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 653045005881 Active Sites [active] 653045005882 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains [Transcription]; Region: COG1327 653045005883 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 653045005884 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 653045005885 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 653045005886 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 653045005887 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045005888 Coenzyme A binding pocket [chemical binding]; other site 653045005889 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045005890 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 653045005891 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 653045005892 GTPase RsgA; Reviewed; Region: PRK01889 653045005893 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 653045005894 GTPase/Zn-binding domain interface [polypeptide binding]; other site 653045005895 GTP/Mg2+ binding site [chemical binding]; other site 653045005896 G4 box; other site 653045005897 G5 box; other site 653045005898 G1 box; other site 653045005899 Switch I region; other site 653045005900 G2 box; other site 653045005901 G3 box; other site 653045005902 Switch II region; other site 653045005903 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045005904 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 653045005905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045005906 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 653045005907 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045005908 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045005909 pyruvate dehydrogenase; Provisional; Region: PRK06546 653045005910 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 653045005911 PYR/PP interface [polypeptide binding]; other site 653045005912 tetramer interface [polypeptide binding]; other site 653045005913 dimer interface [polypeptide binding]; other site 653045005914 TPP binding site [chemical binding]; other site 653045005915 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045005916 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 653045005917 TPP-binding site [chemical binding]; other site 653045005918 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 653045005919 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 653045005920 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 653045005921 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045005922 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045005923 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 653045005924 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045005925 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045005926 DNA-binding site [nucleotide binding]; DNA binding site 653045005927 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 653045005928 Helix-turn-helix domains; Region: HTH; cl00088 653045005929 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 653045005930 FAD binding domain; Region: FAD_binding_4; pfam01565 653045005931 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 653045005932 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045005933 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045005934 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045005935 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 653045005936 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045005937 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045005938 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 653045005939 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 653045005940 XdhC Rossmann domain; Region: XdhC_C; pfam13478 653045005941 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 653045005942 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 653045005943 Catalytic domain of Bacillus cereus phosphatidylinositol-specific phospholipases C and similar proteins; Region: PI-PLCc_BcPLC_like; cd08586 653045005944 active site 653045005945 catalytic site [active] 653045005946 putative metal binding site [ion binding]; other site 653045005947 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 653045005948 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 653045005949 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045005950 DNA binding residues [nucleotide binding] 653045005951 dimerization interface [polypeptide binding]; other site 653045005952 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 653045005953 AMP-binding enzyme; Region: AMP-binding; cl15778 653045005954 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045005955 AMP-binding domain protein; Validated; Region: PRK08315 653045005956 AMP-binding enzyme; Region: AMP-binding; cl15778 653045005957 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045005958 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; cl00988 653045005959 Helix-turn-helix domains; Region: HTH; cl00088 653045005960 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 653045005961 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 653045005962 active site 653045005963 homotetramer interface [polypeptide binding]; other site 653045005964 urate oxidase; Region: urate_oxi; TIGR03383 653045005965 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 653045005966 active site 653045005967 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 653045005968 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 653045005969 active site 653045005970 putative substrate binding pocket [chemical binding]; other site 653045005971 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 653045005972 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 653045005973 PA14 domain; Region: PA14; cl08459 653045005974 malate synthase A; Region: malate_syn_A; TIGR01344 653045005975 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 653045005976 active site 653045005977 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 653045005978 metal-binding site 653045005979 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045005980 Helix-turn-helix domains; Region: HTH; cl00088 653045005981 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045005982 allantoinase; Region: allantoinase; TIGR03178 653045005983 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 653045005984 active site 653045005985 allantoicase; Provisional; Region: PRK13257 653045005986 Allantoicase repeat; Region: Allantoicase; pfam03561 653045005987 Allantoicase repeat; Region: Allantoicase; pfam03561 653045005988 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045005989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045005990 NAD(P) binding site [chemical binding]; other site 653045005991 active site 653045005992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045005993 Helix-turn-helix domains; Region: HTH; cl00088 653045005994 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 653045005995 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 653045005996 DNA binding residues [nucleotide binding] 653045005997 dimer interface [polypeptide binding]; other site 653045005998 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 653045005999 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 653045006000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 653045006001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045006002 non-specific DNA binding site [nucleotide binding]; other site 653045006003 salt bridge; other site 653045006004 sequence-specific DNA binding site [nucleotide binding]; other site 653045006005 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 653045006006 Ca2+ binding site [ion binding]; other site 653045006007 EF-hand domain pair; Region: EF_hand_6; pfam13833 653045006008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045006009 Helix-turn-helix domains; Region: HTH; cl00088 653045006010 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 653045006011 classical (c) SDRs; Region: SDR_c; cd05233 653045006012 NAD(P) binding site [chemical binding]; other site 653045006013 active site 653045006014 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 653045006015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006016 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006017 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 653045006018 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 653045006019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045006020 non-specific DNA binding site [nucleotide binding]; other site 653045006021 salt bridge; other site 653045006022 sequence-specific DNA binding site [nucleotide binding]; other site 653045006023 Cupin domain; Region: Cupin_2; cl09118 653045006024 RNase_Sa. Ribonucleases first isolated from Streptomyces aureofaciens. In general, ribonucleases cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. RNAse Sa is a guanylate...; Region: RNase_Sa; cd00607 653045006025 active site 653045006026 barstar interaction site; other site 653045006027 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 653045006028 substrate binding site [chemical binding]; other site 653045006029 ATP binding site [chemical binding]; other site 653045006030 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 653045006031 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 653045006032 active site 653045006033 intersubunit interface [polypeptide binding]; other site 653045006034 catalytic residue [active] 653045006035 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045006036 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045006037 substrate binding pocket [chemical binding]; other site 653045006038 membrane-bound complex binding site; other site 653045006039 hinge residues; other site 653045006040 Helix-turn-helix domains; Region: HTH; cl00088 653045006041 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045006042 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045006043 DNA-binding site [nucleotide binding]; DNA binding site 653045006044 UTRA domain; Region: UTRA; cl01230 653045006045 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 653045006046 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 653045006047 putative ligand binding site [chemical binding]; other site 653045006048 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045006049 TM-ABC transporter signature motif; other site 653045006050 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 653045006051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006052 Walker A/P-loop; other site 653045006053 ATP binding site [chemical binding]; other site 653045006054 Q-loop/lid; other site 653045006055 ABC transporter signature motif; other site 653045006056 Walker B; other site 653045006057 D-loop; other site 653045006058 H-loop/switch region; other site 653045006059 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 653045006060 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045006061 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045006062 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 653045006063 active site 653045006064 Peptidase family M48; Region: Peptidase_M48; cl12018 653045006065 Helix-turn-helix domains; Region: HTH; cl00088 653045006066 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 653045006067 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045006068 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 653045006069 NodB motif; other site 653045006070 putative active site [active] 653045006071 putative catalytic site [active] 653045006072 putative Zn binding site [ion binding]; other site 653045006073 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 653045006074 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045006075 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045006076 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045006077 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 653045006078 putative catalytic site [active] 653045006079 putative phosphate binding site [ion binding]; other site 653045006080 active site 653045006081 metal binding site A [ion binding]; metal-binding site 653045006082 DNA binding site [nucleotide binding] 653045006083 putative AP binding site [nucleotide binding]; other site 653045006084 putative metal binding site B [ion binding]; other site 653045006085 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 653045006086 active site 653045006087 catalytic triad [active] 653045006088 oxyanion hole [active] 653045006089 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 653045006090 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 653045006091 Walker A/P-loop; other site 653045006092 ATP binding site [chemical binding]; other site 653045006093 Q-loop/lid; other site 653045006094 ABC transporter signature motif; other site 653045006095 Walker B; other site 653045006096 D-loop; other site 653045006097 H-loop/switch region; other site 653045006098 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045006099 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045006100 substrate binding pocket [chemical binding]; other site 653045006101 membrane-bound complex binding site; other site 653045006102 hinge residues; other site 653045006103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045006104 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 653045006105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045006106 dimer interface [polypeptide binding]; other site 653045006107 conserved gate region; other site 653045006108 putative PBP binding loops; other site 653045006109 ABC-ATPase subunit interface; other site 653045006110 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 653045006111 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045006112 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045006113 Helix-turn-helix domains; Region: HTH; cl00088 653045006114 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 653045006115 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006116 Walker A/P-loop; other site 653045006117 ATP binding site [chemical binding]; other site 653045006118 Q-loop/lid; other site 653045006119 ABC transporter signature motif; other site 653045006120 Walker B; other site 653045006121 D-loop; other site 653045006122 H-loop/switch region; other site 653045006123 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 653045006124 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 653045006125 Isochorismatase family; Region: Isochorismatase; pfam00857 653045006126 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 653045006127 catalytic triad [active] 653045006128 conserved cis-peptide bond; other site 653045006129 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045006130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006131 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045006132 Helix-turn-helix domains; Region: HTH; cl00088 653045006133 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 653045006134 N-carbamolyputrescine amidase; Region: PLN02747 653045006135 active site 653045006136 catalytic triad [active] 653045006137 dimer interface [polypeptide binding]; other site 653045006138 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 653045006139 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045006140 inhibitor-cofactor binding pocket; inhibition site 653045006141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045006142 catalytic residue [active] 653045006143 phenylhydantoinase; Validated; Region: PRK08323 653045006144 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 653045006145 tetramer interface [polypeptide binding]; other site 653045006146 active site 653045006147 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 653045006148 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 653045006149 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045006150 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 653045006151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045006152 S-adenosylmethionine binding site [chemical binding]; other site 653045006153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006154 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045006155 putative substrate translocation pore; other site 653045006156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006157 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 653045006158 active site 653045006159 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 653045006160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006161 porphobilinogen deaminase; Region: hemC; TIGR00212 653045006162 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 653045006163 domain interfaces; other site 653045006164 active site 653045006165 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 653045006166 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045006167 Walker A motif; other site 653045006168 ATP binding site [chemical binding]; other site 653045006169 Walker B motif; other site 653045006170 arginine finger; other site 653045006171 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045006172 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 653045006173 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 653045006174 AlkA N-terminal domain; Region: AlkA_N; cl05528 653045006175 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 653045006176 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 653045006177 minor groove reading motif; other site 653045006178 helix-hairpin-helix signature motif; other site 653045006179 substrate binding pocket [chemical binding]; other site 653045006180 active site 653045006181 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 653045006182 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 653045006183 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 653045006184 DNA binding site [nucleotide binding] 653045006185 active site 653045006186 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 653045006187 NAD-dependent deacetylase; Provisional; Region: PRK00481 653045006188 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 653045006189 Glycerate kinase family; Region: Gly_kinase; cl00841 653045006190 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045006191 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 653045006192 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045006193 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045006194 active site 653045006195 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 653045006196 putative active site [active] 653045006197 putative catalytic site [active] 653045006198 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045006199 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 653045006200 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 653045006201 B12 binding site [chemical binding]; other site 653045006202 cobalt ligand [ion binding]; other site 653045006203 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045006204 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 653045006205 NAD(P) binding site [chemical binding]; other site 653045006206 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 653045006207 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045006208 Helix-turn-helix domains; Region: HTH; cl00088 653045006209 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 653045006210 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006211 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045006212 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 653045006213 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006214 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045006215 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 653045006216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045006217 FeS/SAM binding site; other site 653045006218 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045006219 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045006220 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006221 putative substrate translocation pore; other site 653045006222 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045006223 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045006224 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045006225 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045006226 GAF domain; Region: GAF_2; pfam13185 653045006227 GAF domain; Region: GAF; cl15785 653045006228 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045006229 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045006230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045006231 Predicted AdoMet-dependent methyltransferase; Region: AdoMet_MTase; pfam07757 653045006232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045006233 S-adenosylmethionine binding site [chemical binding]; other site 653045006234 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 653045006235 SxDxEG motif; other site 653045006236 active site 653045006237 metal binding site [ion binding]; metal-binding site 653045006238 homopentamer interface [polypeptide binding]; other site 653045006239 hypothetical protein; Provisional; Region: PRK07906 653045006240 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 653045006241 putative metal binding site [ion binding]; other site 653045006242 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045006243 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 653045006244 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 653045006245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045006246 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045006247 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045006248 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045006249 active site 653045006250 metal binding site [ion binding]; metal-binding site 653045006251 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045006252 Methyltransferase domain; Region: Methyltransf_31; pfam13847 653045006253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045006254 S-adenosylmethionine binding site [chemical binding]; other site 653045006255 Winged helix-turn helix; Region: HTH_29; pfam13551 653045006256 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 653045006257 Helix-turn-helix domains; Region: HTH; cl00088 653045006258 FOG: CBS domain [General function prediction only]; Region: COG0517 653045006259 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 653045006260 TIGR03086 family protein; Region: TIGR03086 653045006261 hydroperoxidase II; Provisional; Region: katE; PRK11249 653045006262 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 653045006263 tetramer interface [polypeptide binding]; other site 653045006264 heme binding pocket [chemical binding]; other site 653045006265 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 653045006266 domain interactions; other site 653045006267 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 653045006268 intracellular protease, PfpI family; Region: PfpI; TIGR01382 653045006269 proposed catalytic triad [active] 653045006270 conserved cys residue [active] 653045006271 thiamine pyrophosphate protein; Provisional; Region: PRK08273 653045006272 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 653045006273 PYR/PP interface [polypeptide binding]; other site 653045006274 dimer interface [polypeptide binding]; other site 653045006275 tetramer interface [polypeptide binding]; other site 653045006276 TPP binding site [chemical binding]; other site 653045006277 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045006278 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 653045006279 TPP-binding site [chemical binding]; other site 653045006280 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 653045006281 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 653045006282 PAS domain; Region: PAS_10; pfam13596 653045006283 ANTAR domain; Region: ANTAR; cl04297 653045006284 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774 653045006285 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045006286 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045006287 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045006288 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 653045006289 parallel beta-helix repeat (two copies); Region: para_beta_helix; TIGR03804 653045006290 O-methyltransferase; Region: Methyltransf_2; pfam00891 653045006291 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 653045006292 active site 653045006293 putative catalytic site [active] 653045006294 Polyketide synthesis cyclase; Region: Cyclase_polyket; pfam04673 653045006295 N-terminal aromatase/cyclase domain of the multifunctional protein tetracenomycin (TcmN) and related domains; Region: TcmN_ARO-CYC_like; cd08860 653045006296 putative hydrophobic ligand binding site [chemical binding]; other site 653045006297 active site 653045006298 catalytic residues_2 [active] 653045006299 catalytic residues_1 [active] 653045006300 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045006301 Chain-length factor (CLF) is a factor required for polyketide chain initiation of aromatic antibiotic-producing polyketide synthases (PKSs) of filamentous bacteria. CLFs have been shown to have decarboxylase activity towards malonyl-acyl carrier protein; Region: CLF; cd00832 653045006302 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 653045006303 active site 653045006304 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 653045006305 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 653045006306 dimer interface [polypeptide binding]; other site 653045006307 active site 653045006308 Cupin domain; Region: Cupin_2; cl09118 653045006309 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045006310 SchA/CurD like domain; Region: SchA_CurD; pfam04486 653045006311 SchA/CurD like domain; Region: SchA_CurD; pfam04486 653045006312 FAD binding domain; Region: FAD_binding_3; pfam01494 653045006313 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006315 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 653045006316 Helix-turn-helix domains; Region: HTH; cl00088 653045006317 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 653045006318 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045006319 substrate binding site [chemical binding]; other site 653045006320 oxyanion hole (OAH) forming residues; other site 653045006321 trimer interface [polypeptide binding]; other site 653045006322 Integrase core domain; Region: rve; cl01316 653045006323 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045006324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045006325 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 653045006326 active site 653045006327 dimer interface [polypeptide binding]; other site 653045006328 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045006329 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 653045006330 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006331 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045006332 Helix-turn-helix domains; Region: HTH; cl00088 653045006333 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045006334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 653045006335 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045006336 PAS fold; Region: PAS_3; pfam08447 653045006337 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 653045006338 GAF domain; Region: GAF_2; pfam13185 653045006339 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045006340 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045006341 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045006342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045006343 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 653045006344 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 653045006345 putative ligand binding site [chemical binding]; other site 653045006346 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 653045006347 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045006348 Walker A/P-loop; other site 653045006349 ATP binding site [chemical binding]; other site 653045006350 Q-loop/lid; other site 653045006351 ABC transporter signature motif; other site 653045006352 Walker B; other site 653045006353 D-loop; other site 653045006354 H-loop/switch region; other site 653045006355 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045006356 TM-ABC transporter signature motif; other site 653045006357 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045006358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045006359 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 653045006360 Helix-turn-helix domains; Region: HTH; cl00088 653045006361 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045006362 dimerization interface [polypeptide binding]; other site 653045006363 substrate binding pocket [chemical binding]; other site 653045006364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006365 NADH(P)-binding; Region: NAD_binding_10; pfam13460 653045006366 NAD(P) binding site [chemical binding]; other site 653045006367 active site 653045006368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045006369 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 653045006370 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 653045006371 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045006372 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045006373 Membrane transport protein; Region: Mem_trans; cl09117 653045006374 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 653045006375 tetramer interface [polypeptide binding]; other site 653045006376 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 653045006377 active site 653045006378 Mg2+/Mn2+ binding site [ion binding]; other site 653045006379 proline/glycine betaine transporter; Provisional; Region: PRK10642 653045006380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006381 putative substrate translocation pore; other site 653045006382 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045006383 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045006384 non-specific DNA binding site [nucleotide binding]; other site 653045006385 salt bridge; other site 653045006386 sequence-specific DNA binding site [nucleotide binding]; other site 653045006387 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 653045006388 aromatic arch; other site 653045006389 DCoH dimer interaction site [polypeptide binding]; other site 653045006390 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 653045006391 DCoH tetramer interaction site [polypeptide binding]; other site 653045006392 substrate binding site [chemical binding]; other site 653045006393 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 653045006394 DNA photolyase; Region: DNA_photolyase; pfam00875 653045006395 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 653045006396 Putative zinc-finger; Region: zf-HC2; cl15806 653045006397 Anti-sigma-K factor rskA; Region: RskA; pfam10099 653045006398 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 653045006399 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045006400 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045006401 DNA binding residues [nucleotide binding] 653045006402 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045006403 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045006404 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045006405 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045006406 active site 653045006407 catalytic tetrad [active] 653045006408 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 653045006409 AMP-binding enzyme; Region: AMP-binding; cl15778 653045006410 Helix-turn-helix domains; Region: HTH; cl00088 653045006411 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045006412 dimerization interface [polypeptide binding]; other site 653045006413 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 653045006414 Membrane transport protein; Region: Mem_trans; cl09117 653045006415 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 653045006416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045006417 S-adenosylmethionine binding site [chemical binding]; other site 653045006418 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045006419 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045006420 active site 653045006421 metal binding site [ion binding]; metal-binding site 653045006422 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 653045006423 catalytic site [active] 653045006424 BNR repeat-like domain; Region: BNR_2; pfam13088 653045006425 Asp-box motif; other site 653045006426 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 653045006427 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 653045006428 catalytic residues [active] 653045006429 catalytic nucleophile [active] 653045006430 Presynaptic Site I dimer interface [polypeptide binding]; other site 653045006431 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 653045006432 Synaptic Flat tetramer interface [polypeptide binding]; other site 653045006433 Synaptic Site I dimer interface [polypeptide binding]; other site 653045006434 DNA binding site [nucleotide binding] 653045006435 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 653045006436 DNA-binding interface [nucleotide binding]; DNA binding site 653045006437 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045006438 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045006439 Helix-turn-helix domains; Region: HTH; cl00088 653045006440 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045006441 NB-ARC domain; Region: NB-ARC; pfam00931 653045006442 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 653045006443 TPR motif; other site 653045006444 binding surface 653045006445 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045006446 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045006447 TPR motif; other site 653045006448 binding surface 653045006449 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045006450 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045006451 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 653045006452 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 653045006453 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045006454 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045006455 DNA binding residues [nucleotide binding] 653045006456 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045006457 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 653045006458 classical (c) SDRs; Region: SDR_c; cd05233 653045006459 NAD(P) binding site [chemical binding]; other site 653045006460 active site 653045006461 Probable transposase; Region: OrfB_IS605; pfam01385 653045006462 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045006463 Helix-turn-helix domains; Region: HTH; cl00088 653045006464 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045006465 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 653045006466 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045006467 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 653045006468 4Fe-4S binding domain; Region: Fer4; cl02805 653045006469 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045006470 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 653045006471 putative dimer interface [polypeptide binding]; other site 653045006472 [2Fe-2S] cluster binding site [ion binding]; other site 653045006473 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 653045006474 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 653045006475 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 653045006476 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045006477 molybdopterin cofactor binding site; other site 653045006478 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 653045006479 molybdopterin cofactor binding site; other site 653045006480 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 653045006481 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006482 putative substrate translocation pore; other site 653045006483 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045006484 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045006485 DNA-binding site [nucleotide binding]; DNA binding site 653045006486 FCD domain; Region: FCD; cl11656 653045006487 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 653045006488 Helix-turn-helix domains; Region: HTH; cl00088 653045006489 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045006490 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045006491 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 653045006492 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045006493 Walker A/P-loop; other site 653045006494 ATP binding site [chemical binding]; other site 653045006495 Q-loop/lid; other site 653045006496 ABC transporter signature motif; other site 653045006497 Walker B; other site 653045006498 D-loop; other site 653045006499 H-loop/switch region; other site 653045006500 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 653045006501 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045006502 TM-ABC transporter signature motif; other site 653045006503 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_3; cd06311 653045006504 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 653045006505 putative ligand binding site [chemical binding]; other site 653045006506 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045006507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006508 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045006509 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 653045006510 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 653045006511 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 653045006512 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 653045006513 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 653045006514 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 653045006515 metal binding site [ion binding]; metal-binding site 653045006516 ligand binding site [chemical binding]; other site 653045006517 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 653045006518 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 653045006519 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 653045006520 UbiA prenyltransferase family; Region: UbiA; cl00337 653045006521 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045006522 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045006523 active site 653045006524 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045006525 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 653045006526 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 653045006527 Sulfatase; Region: Sulfatase; cl10460 653045006528 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045006529 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045006530 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 653045006531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006532 putative substrate translocation pore; other site 653045006533 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045006534 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 653045006535 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006536 CoA-ligase; Region: Ligase_CoA; cl02894 653045006537 formyl-coenzyme A transferase; Provisional; Region: PRK05398 653045006538 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045006539 hypothetical protein; Provisional; Region: PRK05858 653045006540 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 653045006541 PYR/PP interface [polypeptide binding]; other site 653045006542 dimer interface [polypeptide binding]; other site 653045006543 TPP binding site [chemical binding]; other site 653045006544 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045006545 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 653045006546 TPP-binding site; other site 653045006547 dimer interface [polypeptide binding]; other site 653045006548 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 653045006549 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045006550 CoA-ligase; Region: Ligase_CoA; cl02894 653045006551 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 653045006552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006553 CoA-ligase; Region: Ligase_CoA; cl02894 653045006554 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045006555 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045006556 NAD(P) binding site [chemical binding]; other site 653045006557 catalytic residues [active] 653045006558 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045006559 MULE transposase domain; Region: MULE; pfam10551 653045006560 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 653045006561 active site 653045006562 Helix-turn-helix domains; Region: HTH; cl00088 653045006563 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 653045006564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045006565 S-adenosylmethionine binding site [chemical binding]; other site 653045006566 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045006567 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045006568 DNA binding residues [nucleotide binding] 653045006569 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 653045006570 replication factor C large subunit; Provisional; Region: PRK04195 653045006571 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045006572 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006573 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 653045006574 Bacterial transcriptional activator domain; Region: BTAD; smart01043 653045006575 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 653045006576 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 653045006577 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 653045006578 ATP binding site [chemical binding]; other site 653045006579 Walker A motif; other site 653045006580 hexamer interface [polypeptide binding]; other site 653045006581 Walker B motif; other site 653045006582 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 653045006583 SAF domain; Region: SAF; cl00555 653045006584 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045006585 transcriptional repressor DicA; Reviewed; Region: PRK09706 653045006586 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045006587 non-specific DNA binding site [nucleotide binding]; other site 653045006588 salt bridge; other site 653045006589 sequence-specific DNA binding site [nucleotide binding]; other site 653045006590 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045006591 active site 653045006592 metal binding site [ion binding]; metal-binding site 653045006593 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045006594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045006595 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 653045006596 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 653045006597 dimerization interface [polypeptide binding]; other site 653045006598 active site 653045006599 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 653045006600 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 653045006601 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 653045006602 topology modulation protein; Reviewed; Region: PRK08118 653045006603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006604 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045006605 S-adenosylmethionine binding site [chemical binding]; other site 653045006606 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045006607 catalytic core [active] 653045006608 Phosphotransferase enzyme family; Region: APH; pfam01636 653045006609 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045006610 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045006611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006612 NAD(P) binding site [chemical binding]; other site 653045006613 active site 653045006614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006615 active site 653045006616 NAD+ binding site [chemical binding]; other site 653045006617 oligomerization interface [polypeptide binding]; other site 653045006618 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 653045006619 nudix motif; other site 653045006620 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 653045006621 Ligand binding site; other site 653045006622 oligomer interface; other site 653045006623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045006624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045006625 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045006626 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006627 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 653045006628 Ubiquitin-like proteins; Region: UBQ; cl00155 653045006629 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 653045006630 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006631 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 653045006632 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006633 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 653045006634 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006635 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 653045006636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006637 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 653045006638 Walker A/P-loop; other site 653045006639 ATP binding site [chemical binding]; other site 653045006640 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 653045006641 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006642 ABC transporter signature motif; other site 653045006643 Walker B; other site 653045006644 D-loop; other site 653045006645 H-loop/switch region; other site 653045006646 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 653045006647 Family description; Region: UvrD_C_2; cl15862 653045006648 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045006650 ATP-binding site [chemical binding]; other site 653045006651 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 653045006652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045006653 ATP binding site [chemical binding]; other site 653045006654 putative Mg++ binding site [ion binding]; other site 653045006655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045006656 nucleotide binding region [chemical binding]; other site 653045006657 ATP-binding site [chemical binding]; other site 653045006658 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045006659 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045006660 active site 653045006661 ATP binding site [chemical binding]; other site 653045006662 substrate binding site [chemical binding]; other site 653045006663 activation loop (A-loop); other site 653045006664 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045006665 Competence protein CoiA-like family; Region: CoiA; cl11541 653045006666 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 653045006667 Zc3h12a-like Ribonuclease NYN domain; Region: RNase_Zc3h12a; pfam11977 653045006668 Protein of unknown function (DUF429); Region: DUF429; cl12046 653045006669 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 653045006670 putative active site [active] 653045006671 catalytic site [active] 653045006672 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045006673 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045006674 DNA binding residues [nucleotide binding] 653045006675 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl02940 653045006676 beta-clamp/clamp loader binding surface; other site 653045006677 beta-clamp/translesion DNA polymerase binding surface; other site 653045006678 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 653045006679 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 653045006680 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 653045006681 active site 653045006682 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 653045006683 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 653045006684 active site 653045006685 oxyanion hole [active] 653045006686 catalytic triad [active] 653045006687 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 653045006688 Helix-turn-helix domains; Region: HTH; cl00088 653045006689 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 653045006690 putative active site [active] 653045006691 putative FMN binding site [chemical binding]; other site 653045006692 putative substrate binding site [chemical binding]; other site 653045006693 putative catalytic residue [active] 653045006694 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045006695 classical (c) SDRs; Region: SDR_c; cd05233 653045006696 NAD(P) binding site [chemical binding]; other site 653045006697 active site 653045006698 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045006699 Helix-turn-helix domains; Region: HTH; cl00088 653045006700 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045006701 dimerization interface [polypeptide binding]; other site 653045006702 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045006703 classical (c) SDRs; Region: SDR_c; cd05233 653045006704 NAD(P) binding site [chemical binding]; other site 653045006705 active site 653045006706 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 653045006707 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 653045006708 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045006709 putative methyltransferase; Provisional; Region: PRK14968 653045006710 Predicted acyl esterases [General function prediction only]; Region: COG2936 653045006711 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045006712 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045006713 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK12815 653045006714 Protein kinase domain; Region: Pkinase; pfam00069 653045006715 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045006716 active site 653045006717 ATP binding site [chemical binding]; other site 653045006718 substrate binding site [chemical binding]; other site 653045006719 activation loop (A-loop); other site 653045006720 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045006721 structural tetrad; other site 653045006722 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045006723 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045006724 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 653045006725 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045006726 DNA binding residues [nucleotide binding] 653045006727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045006728 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045006729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045006730 salt bridge; other site 653045006731 non-specific DNA binding site [nucleotide binding]; other site 653045006732 sequence-specific DNA binding site [nucleotide binding]; other site 653045006733 short chain dehydrogenase; Provisional; Region: PRK12828 653045006734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006735 NAD(P) binding site [chemical binding]; other site 653045006736 active site 653045006737 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 653045006738 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 653045006739 active site 653045006740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045006741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045006742 DNA binding site [nucleotide binding] 653045006743 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045006744 ligand binding site [chemical binding]; other site 653045006745 dimerization interface [polypeptide binding]; other site 653045006746 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045006747 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045006748 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045006749 active site 653045006750 catalytic tetrad [active] 653045006751 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045006752 dimerization interface [polypeptide binding]; other site 653045006753 putative DNA binding site [nucleotide binding]; other site 653045006754 putative Zn2+ binding site [ion binding]; other site 653045006755 Muconolactone delta-isomerase; Region: MIase; cl01992 653045006756 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 653045006757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045006758 phosphorylation site [posttranslational modification] 653045006759 dimer interface [polypeptide binding]; other site 653045006760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045006761 ATP binding site [chemical binding]; other site 653045006762 Mg2+ binding site [ion binding]; other site 653045006763 G-X-G motif; other site 653045006764 Helix-turn-helix domains; Region: HTH; cl00088 653045006765 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 653045006766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045006767 motif II; other site 653045006768 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045006769 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 653045006770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006771 glucose-6-phosphate 1-dehydrogenase; Provisional; Region: PRK12854 653045006772 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 653045006773 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 653045006774 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 653045006775 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045006776 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045006777 classical (c) SDRs; Region: SDR_c; cd05233 653045006778 NAD(P) binding site [chemical binding]; other site 653045006779 active site 653045006780 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045006781 Helix-turn-helix domains; Region: HTH; cl00088 653045006782 Helix-turn-helix domains; Region: HTH; cl00088 653045006783 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 653045006784 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 653045006785 PYR/PP interface [polypeptide binding]; other site 653045006786 dimer interface [polypeptide binding]; other site 653045006787 TPP binding site [chemical binding]; other site 653045006788 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045006789 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 653045006790 TPP-binding site [chemical binding]; other site 653045006791 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 653045006792 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045006793 H-loop/switch region; other site 653045006794 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045006795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045006796 non-specific DNA binding site [nucleotide binding]; other site 653045006797 salt bridge; other site 653045006798 sequence-specific DNA binding site [nucleotide binding]; other site 653045006799 Domain of unknown function (DUF955); Region: DUF955; cl01076 653045006800 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 653045006801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045006802 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045006803 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045006804 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 653045006805 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 653045006806 active site 653045006807 dimer interface [polypeptide binding]; other site 653045006808 non-prolyl cis peptide bond; other site 653045006809 insertion regions; other site 653045006810 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 653045006811 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045006812 active site 653045006813 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045006814 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 653045006815 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 653045006816 active site 653045006817 dimer interface [polypeptide binding]; other site 653045006818 non-prolyl cis peptide bond; other site 653045006819 insertion regions; other site 653045006820 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045006821 Helix-turn-helix domains; Region: HTH; cl00088 653045006822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045006823 dimerization interface [polypeptide binding]; other site 653045006824 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 653045006825 F420-dependent oxidoreductase, G6PDH family; Region: F420_G6P_family; TIGR03557 653045006826 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 653045006827 active site 653045006828 catalytic triad [active] 653045006829 oxyanion hole [active] 653045006830 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 653045006831 active site 653045006832 catalytic triad [active] 653045006833 oxyanion hole [active] 653045006834 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045006835 Helix-turn-helix domains; Region: HTH; cl00088 653045006836 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045006837 choline dehydrogenase; Validated; Region: PRK02106 653045006838 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 653045006839 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 653045006840 Spore germination protein; Region: Spore_permease; cl15802 653045006841 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 653045006842 tetramerization interface [polypeptide binding]; other site 653045006843 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045006844 NAD(P) binding site [chemical binding]; other site 653045006845 catalytic residues [active] 653045006846 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045006847 non-specific DNA binding site [nucleotide binding]; other site 653045006848 salt bridge; other site 653045006849 sequence-specific DNA binding site [nucleotide binding]; other site 653045006850 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 653045006851 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 653045006852 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045006853 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045006854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045006855 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045006856 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045006857 YCII-related domain; Region: YCII; cl00999 653045006858 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 653045006859 Active_site [active] 653045006860 Protein of unknown function (DUF1203); Region: DUF1203; pfam06718 653045006861 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 653045006862 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 653045006863 inhibitor site; inhibition site 653045006864 active site 653045006865 dimer interface [polypeptide binding]; other site 653045006866 catalytic residue [active] 653045006867 putative sialic acid transporter; Provisional; Region: PRK03893 653045006868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006869 putative substrate translocation pore; other site 653045006870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006871 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 653045006872 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045006873 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 653045006874 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045006875 dimer interface [polypeptide binding]; other site 653045006876 active site 653045006877 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 653045006878 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045006879 substrate binding site [chemical binding]; other site 653045006880 oxyanion hole (OAH) forming residues; other site 653045006881 trimer interface [polypeptide binding]; other site 653045006882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006883 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045006884 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 653045006885 Helix-turn-helix domains; Region: HTH; cl00088 653045006886 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045006887 dimerization interface [polypeptide binding]; other site 653045006888 substrate binding pocket [chemical binding]; other site 653045006889 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045006890 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 653045006891 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045006892 DNA binding residues [nucleotide binding] 653045006893 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045006894 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045006895 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045006896 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 653045006897 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 653045006898 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 653045006899 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 653045006900 Zn binding site [ion binding]; other site 653045006901 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 653045006902 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045006903 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 653045006904 active site 653045006905 Zn binding site [ion binding]; other site 653045006906 BCCT family transporter; Region: BCCT; cl00569 653045006907 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 653045006908 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 653045006909 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 653045006910 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 653045006911 RNA binding site [nucleotide binding]; other site 653045006912 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045006913 enoyl-CoA hydratase; Provisional; Region: PRK06127 653045006914 substrate binding site [chemical binding]; other site 653045006915 oxyanion hole (OAH) forming residues; other site 653045006916 trimer interface [polypeptide binding]; other site 653045006917 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045006918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045006919 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045006920 nudix motif; other site 653045006921 Cation efflux family; Region: Cation_efflux; cl00316 653045006922 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 653045006923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006924 NAD(P) binding site [chemical binding]; other site 653045006925 active site 653045006926 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045006927 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 653045006928 active site 653045006929 metal-binding site 653045006930 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 653045006931 active site 653045006932 metal binding site [ion binding]; metal-binding site 653045006933 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045006934 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 653045006935 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045006936 active site 653045006937 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045006938 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 653045006939 ABC_KpsT_Wzt The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export. Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220 653045006940 Walker A/P-loop; other site 653045006941 ATP binding site [chemical binding]; other site 653045006942 Q-loop/lid; other site 653045006943 ABC transporter signature motif; other site 653045006944 Walker B; other site 653045006945 D-loop; other site 653045006946 H-loop/switch region; other site 653045006947 Helix-turn-helix domains; Region: HTH; cl00088 653045006948 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045006949 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045006950 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045006951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045006952 putative substrate translocation pore; other site 653045006953 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 653045006954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006955 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045006956 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045006957 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045006958 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045006959 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 653045006960 putative NAD(P) binding site [chemical binding]; other site 653045006961 active site 653045006962 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045006963 active site 653045006964 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045006965 active site 653045006966 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045006967 NAD(P) binding site [chemical binding]; other site 653045006968 active site 653045006969 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045006970 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 653045006971 putative NADP binding site [chemical binding]; other site 653045006972 active site 653045006973 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045006974 short chain dehydrogenase; Validated; Region: PRK06182 653045006975 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045006976 NADP binding site [chemical binding]; other site 653045006977 active site 653045006978 steroid binding site; other site 653045006979 Cytochrome P450; Region: p450; pfam00067 653045006980 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045006981 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045006982 Helix-turn-helix domains; Region: HTH; cl00088 653045006983 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 653045006984 substrate binding pocket [chemical binding]; other site 653045006985 substrate-Mg2+ binding site; other site 653045006986 aspartate-rich region 1; other site 653045006987 aspartate-rich region 2; other site 653045006988 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 653045006989 active site lid residues [active] 653045006990 substrate binding pocket [chemical binding]; other site 653045006991 catalytic residues [active] 653045006992 substrate-Mg2+ binding site; other site 653045006993 aspartate-rich region 1; other site 653045006994 aspartate-rich region 2; other site 653045006995 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 653045006996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045006997 substrate binding pocket [chemical binding]; other site 653045006998 chain length determination region; other site 653045006999 substrate-Mg2+ binding site; other site 653045007000 catalytic residues [active] 653045007001 aspartate-rich region 1; other site 653045007002 active site lid residues [active] 653045007003 aspartate-rich region 2; other site 653045007004 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 653045007005 Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY) and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892 653045007006 Active site cavity [active] 653045007007 catalytic acid [active] 653045007008 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 653045007009 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 653045007010 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045007011 FeS/SAM binding site; other site 653045007012 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 653045007013 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 653045007014 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 653045007015 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 653045007016 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 653045007017 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 653045007018 TPP-binding site; other site 653045007019 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 653045007020 PYR/PP interface [polypeptide binding]; other site 653045007021 dimer interface [polypeptide binding]; other site 653045007022 TPP binding site [chemical binding]; other site 653045007023 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 653045007024 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045007025 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 653045007026 inhibitor-cofactor binding pocket; inhibition site 653045007027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045007028 catalytic residue [active] 653045007029 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 653045007030 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 653045007031 reactive center loop; other site 653045007032 Protein tyrosine/serine phosphatase [Signal transduction mechanisms]; Region: COG2365 653045007033 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 653045007034 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 653045007035 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 653045007036 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045007037 catalytic site [active] 653045007038 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 653045007039 active site 653045007040 catalytic triad [active] 653045007041 oxyanion hole [active] 653045007042 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045007043 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045007044 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045007045 non-specific DNA binding site [nucleotide binding]; other site 653045007046 salt bridge; other site 653045007047 sequence-specific DNA binding site [nucleotide binding]; other site 653045007048 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045007049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 653045007050 FeS/SAM binding site; other site 653045007051 coproporphyrinogen III oxidase; Validated; Region: PRK08208 653045007052 HemN C-terminal domain; Region: HemN_C; pfam06969 653045007053 Sulfatase; Region: Sulfatase; cl10460 653045007054 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 653045007055 Substrate binding site [chemical binding]; other site 653045007056 Chitin/cellulose binding domain. Putative carbohydrate binding domain found in many different glycosyl hydrolase enzymes. May occur in tandem arrangements; Region: ChtBD3; cl00046 653045007057 Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325 653045007058 putative sugar binding site [chemical binding]; other site 653045007059 catalytic residues [active] 653045007060 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045007061 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045007062 Glycosyl hydrolase family 46 chitosanase domain. This family are composed of the chitosanase enzymes which hydrolyzes chitosan, a biopolymer of beta (1,4)-linked -D-glucosamine (GlcN) residues produced by partial or full deacetylation of chitin; Region: chitosanase_glyco_hydro_46; cd00978 653045007063 chitosan binding site [chemical binding]; other site 653045007064 catalytic residues [active] 653045007065 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045007066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045007067 Peptidase C26; Region: Peptidase_C26; pfam07722 653045007068 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 653045007069 catalytic triad [active] 653045007070 ethanolamine permease; Region: 2A0305; TIGR00908 653045007071 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045007072 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045007073 DNA-binding site [nucleotide binding]; DNA binding site 653045007074 FCD domain; Region: FCD; cl11656 653045007075 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 653045007076 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 653045007077 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045007078 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 653045007079 NAD(P) binding site [chemical binding]; other site 653045007080 catalytic residues [active] 653045007081 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 653045007082 classical (c) SDRs; Region: SDR_c; cd05233 653045007083 NAD(P) binding site [chemical binding]; other site 653045007084 active site 653045007085 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 653045007086 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045007087 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045007088 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045007089 putative NAD(P) binding site [chemical binding]; other site 653045007090 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 2; Region: PLPDE_III_DSD_D-TA_like_2; cd06813 653045007091 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 653045007092 dimer interface [polypeptide binding]; other site 653045007093 active site 653045007094 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045007095 substrate binding site [chemical binding]; other site 653045007096 catalytic residue [active] 653045007097 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 653045007098 active site 653045007099 catalytic residues [active] 653045007100 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 653045007101 amphipathic channel; other site 653045007102 Asn-Pro-Ala signature motifs; other site 653045007103 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 653045007104 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 653045007105 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 653045007106 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 653045007107 ribosomal protein L20; Region: rpl20; CHL00068 653045007108 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 653045007109 23S rRNA binding site [nucleotide binding]; other site 653045007110 L21 binding site [polypeptide binding]; other site 653045007111 L13 binding site [polypeptide binding]; other site 653045007112 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 653045007113 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 653045007114 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 653045007115 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 653045007116 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045007117 dimer interface [polypeptide binding]; other site 653045007118 phosphorylation site [posttranslational modification] 653045007119 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045007120 ATP binding site [chemical binding]; other site 653045007121 Mg2+ binding site [ion binding]; other site 653045007122 G-X-G motif; other site 653045007123 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 653045007124 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 653045007125 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 653045007126 dimer interface [polypeptide binding]; other site 653045007127 motif 1; other site 653045007128 active site 653045007129 motif 2; other site 653045007130 motif 3; other site 653045007131 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 653045007132 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 653045007133 putative tRNA-binding site [nucleotide binding]; other site 653045007134 B3/4 domain; Region: B3_4; cl11458 653045007135 tRNA synthetase B5 domain; Region: B5; cl08394 653045007136 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 653045007137 dimer interface [polypeptide binding]; other site 653045007138 motif 1; other site 653045007139 motif 3; other site 653045007140 motif 2; other site 653045007141 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 653045007142 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045007143 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 653045007144 dimer interface [polypeptide binding]; other site 653045007145 active site 653045007146 ADP-ribose binding site [chemical binding]; other site 653045007147 nudix motif; other site 653045007148 metal binding site [ion binding]; metal-binding site 653045007149 cyclase homology domain; Region: CHD; cd07302 653045007150 nucleotidyl binding site; other site 653045007151 metal binding site [ion binding]; metal-binding site 653045007152 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045007153 ligand binding site [chemical binding]; other site 653045007154 flexible hinge region; other site 653045007155 Helix-turn-helix domains; Region: HTH; cl00088 653045007156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007157 MgtC family; Region: MgtC; pfam02308 653045007158 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 653045007159 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 653045007160 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045007161 S-adenosylmethionine binding site [chemical binding]; other site 653045007162 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 653045007163 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007164 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045007165 VPS10 domain; Region: VPS10; smart00602 653045007166 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 653045007167 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 653045007168 EamA-like transporter family; Region: EamA; cl01037 653045007169 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 653045007170 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045007171 DNA-binding site [nucleotide binding]; DNA binding site 653045007172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045007173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045007174 homodimer interface [polypeptide binding]; other site 653045007175 catalytic residue [active] 653045007176 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 653045007177 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 653045007178 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045007179 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 653045007180 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045007181 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045007182 Helix-turn-helix domains; Region: HTH; cl00088 653045007183 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 653045007184 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 653045007185 active site 653045007186 catalytic triad [active] 653045007187 oxyanion hole [active] 653045007188 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045007189 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 653045007190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007191 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 653045007192 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 653045007193 heterotetramer interface [polypeptide binding]; other site 653045007194 active site pocket [active] 653045007195 cleavage site 653045007196 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 653045007197 feedback inhibition sensing region; other site 653045007198 homohexameric interface [polypeptide binding]; other site 653045007199 nucleotide binding site [chemical binding]; other site 653045007200 N-acetyl-L-glutamate binding site [chemical binding]; other site 653045007201 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 653045007202 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045007203 inhibitor-cofactor binding pocket; inhibition site 653045007204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045007205 catalytic residue [active] 653045007206 arginine repressor; Provisional; Region: PRK03341 653045007207 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 653045007208 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 653045007209 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 653045007210 Membrane transport protein; Region: Mem_trans; cl09117 653045007211 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045007212 Protein of unknown function, DUF488; Region: DUF488; cl01246 653045007213 ApbE family; Region: ApbE; cl00643 653045007214 FMN-binding domain; Region: FMN_bind; cl01081 653045007215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045007216 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045007217 Probable transposase; Region: OrfB_IS605; pfam01385 653045007218 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045007219 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 653045007220 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 653045007221 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 653045007222 FAD binding pocket [chemical binding]; other site 653045007223 FAD binding motif [chemical binding]; other site 653045007224 phosphate binding motif [ion binding]; other site 653045007225 beta-alpha-beta structure motif; other site 653045007226 NAD binding pocket [chemical binding]; other site 653045007227 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 653045007228 putative catalytic site [active] 653045007229 putative metal binding site [ion binding]; other site 653045007230 putative phosphate binding site [ion binding]; other site 653045007231 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045007232 putative active site [active] 653045007233 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 653045007234 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 653045007235 ANP binding site [chemical binding]; other site 653045007236 Substrate Binding Site II [chemical binding]; other site 653045007237 Substrate Binding Site I [chemical binding]; other site 653045007238 argininosuccinate lyase; Provisional; Region: PRK00855 653045007239 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 653045007240 active sites [active] 653045007241 tetramer interface [polypeptide binding]; other site 653045007242 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045007243 active site 653045007244 catalytic tetrad [active] 653045007245 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045007246 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 653045007247 putative acyl-acceptor binding pocket; other site 653045007248 Glycerophosphodiester phosphodiesterase domain of Streptomycin coelicolor (GlpQ1) and similar proteins; Region: GDPD_ScGlpQ1_like; cd08602 653045007249 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 653045007250 putative active site [active] 653045007251 catalytic site [active] 653045007252 putative metal binding site [ion binding]; other site 653045007253 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045007254 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 653045007255 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045007256 Coenzyme A binding pocket [chemical binding]; other site 653045007257 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 653045007258 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045007259 motif II; other site 653045007260 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 653045007261 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 653045007262 Walker A/P-loop; other site 653045007263 ATP binding site [chemical binding]; other site 653045007264 Q-loop/lid; other site 653045007265 ABC transporter signature motif; other site 653045007266 Walker B; other site 653045007267 D-loop; other site 653045007268 H-loop/switch region; other site 653045007269 NIL domain; Region: NIL; cl09633 653045007270 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045007271 dimer interface [polypeptide binding]; other site 653045007272 conserved gate region; other site 653045007273 putative PBP binding loops; other site 653045007274 ABC-ATPase subunit interface; other site 653045007275 NMT1-like family; Region: NMT1_2; cl15260 653045007276 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045007277 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045007278 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045007279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045007280 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 653045007281 putative FMN binding site [chemical binding]; other site 653045007282 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 653045007283 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 653045007284 putative dimer interface [polypeptide binding]; other site 653045007285 active site pocket [active] 653045007286 putative cataytic base [active] 653045007287 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007288 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045007289 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 653045007290 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 653045007291 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 653045007292 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045007293 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045007294 active site 653045007295 ATP binding site [chemical binding]; other site 653045007296 substrate binding site [chemical binding]; other site 653045007297 activation loop (A-loop); other site 653045007298 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045007299 MULE transposase domain; Region: MULE; pfam10551 653045007300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045007301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045007302 Helix-turn-helix domains; Region: HTH; cl00088 653045007303 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045007304 Helix-turn-helix domains; Region: HTH; cl00088 653045007305 Putative cyclase; Region: Cyclase; cl00814 653045007306 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 653045007307 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 653045007308 chorismate binding enzyme; Region: Chorismate_bind; cl10555 653045007309 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 653045007310 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045007311 catalytic residue [active] 653045007312 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045007313 Coenzyme A binding pocket [chemical binding]; other site 653045007314 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045007315 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 653045007316 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045007317 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 653045007318 Putative transmembrane protein (PGPGW); Region: PGPGW; cl09870 653045007319 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045007320 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045007321 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 653045007322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045007323 putative PBP binding loops; other site 653045007324 dimer interface [polypeptide binding]; other site 653045007325 ABC-ATPase subunit interface; other site 653045007326 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045007327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045007328 dimer interface [polypeptide binding]; other site 653045007329 conserved gate region; other site 653045007330 putative PBP binding loops; other site 653045007331 ABC-ATPase subunit interface; other site 653045007332 Protein of unknown function, DUF624; Region: DUF624; cl02369 653045007333 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045007334 hydrophobic ligand binding site; other site 653045007335 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045007336 active site 653045007337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045007338 metal binding site [ion binding]; metal-binding site 653045007339 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 653045007340 active site 653045007341 catalytic site [active] 653045007342 substrate binding site [chemical binding]; other site 653045007343 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 653045007344 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 653045007345 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 653045007346 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 653045007347 active site 653045007348 dimer interface [polypeptide binding]; other site 653045007349 motif 1; other site 653045007350 motif 2; other site 653045007351 motif 3; other site 653045007352 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 653045007353 anticodon binding site; other site 653045007354 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 653045007355 nucleotide binding site/active site [active] 653045007356 HIT family signature motif; other site 653045007357 catalytic residue [active] 653045007358 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 653045007359 elongation factor G; Reviewed; Region: PRK12740 653045007360 G1 box; other site 653045007361 putative GEF interaction site [polypeptide binding]; other site 653045007362 GTP/Mg2+ binding site [chemical binding]; other site 653045007363 Switch I region; other site 653045007364 G2 box; other site 653045007365 G3 box; other site 653045007366 Switch II region; other site 653045007367 G4 box; other site 653045007368 G5 box; other site 653045007369 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 653045007370 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 653045007371 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 653045007372 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045007373 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 653045007374 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045007375 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 653045007376 putative acyl-acceptor binding pocket; other site 653045007377 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045007378 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 653045007379 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 653045007380 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 653045007381 active site 653045007382 multimer interface [polypeptide binding]; other site 653045007383 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 653045007384 predicted active site [active] 653045007385 catalytic triad [active] 653045007386 Transcriptional regulator; Region: Transcrip_reg; cl00361 653045007387 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 653045007388 active site 653045007389 putative DNA-binding cleft [nucleotide binding]; other site 653045007390 dimer interface [polypeptide binding]; other site 653045007391 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 653045007392 RuvA N terminal domain; Region: RuvA_N; pfam01330 653045007393 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 653045007394 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 653045007395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045007396 Walker A motif; other site 653045007397 ATP binding site [chemical binding]; other site 653045007398 Walker B motif; other site 653045007399 arginine finger; other site 653045007400 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 653045007401 Preprotein translocase subunit; Region: YajC; cl00806 653045007402 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 653045007403 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 653045007404 Protein export membrane protein; Region: SecD_SecF; cl14618 653045007405 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 653045007406 Protein export membrane protein; Region: SecD_SecF; cl14618 653045007407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 653045007408 active site 653045007409 Protein of unknown function (DUF3275); Region: DUF3275; pfam11679 653045007410 (p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691 653045007411 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 653045007412 Zn2+ binding site [ion binding]; other site 653045007413 Mg2+ binding site [ion binding]; other site 653045007414 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 653045007415 synthetase active site [active] 653045007416 NTP binding site [chemical binding]; other site 653045007417 metal binding site [ion binding]; metal-binding site 653045007418 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 653045007419 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 653045007420 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 653045007421 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 653045007422 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 653045007423 peptidyl-prolyl cis-trans isomerase B (rotamase B); Provisional; Region: PRK10791 653045007424 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 653045007425 active site 653045007426 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045007427 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 653045007428 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 653045007429 dimer interface [polypeptide binding]; other site 653045007430 motif 1; other site 653045007431 active site 653045007432 motif 2; other site 653045007433 motif 3; other site 653045007434 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 653045007435 anticodon binding site; other site 653045007436 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045007437 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045007438 active site 653045007439 phosphorylation site [posttranslational modification] 653045007440 intermolecular recognition site; other site 653045007441 dimerization interface [polypeptide binding]; other site 653045007442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045007443 DNA binding residues [nucleotide binding] 653045007444 dimerization interface [polypeptide binding]; other site 653045007445 Histidine kinase; Region: HisKA_3; pfam07730 653045007446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045007447 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045007448 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045007449 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 653045007450 Walker A/P-loop; other site 653045007451 ATP binding site [chemical binding]; other site 653045007452 Q-loop/lid; other site 653045007453 ABC transporter signature motif; other site 653045007454 Walker B; other site 653045007455 D-loop; other site 653045007456 H-loop/switch region; other site 653045007457 Vitamin K epoxide reductase family; Region: VKOR; cl01729 653045007458 recombination factor protein RarA; Reviewed; Region: PRK13342 653045007459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045007460 Walker A motif; other site 653045007461 ATP binding site [chemical binding]; other site 653045007462 Walker B motif; other site 653045007463 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 653045007464 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 653045007465 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 653045007466 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 653045007467 RNA binding surface [nucleotide binding]; other site 653045007468 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 653045007469 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 653045007470 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 653045007471 motif 1; other site 653045007472 active site 653045007473 motif 2; other site 653045007474 motif 3; other site 653045007475 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 653045007476 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 653045007477 YceG-like family; Region: YceG; pfam02618 653045007478 proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675 653045007479 dimerization interface [polypeptide binding]; other site 653045007480 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 653045007481 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 653045007482 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 653045007483 NAD(P) binding site [chemical binding]; other site 653045007484 shikimate binding site; other site 653045007485 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 653045007486 Tetramer interface [polypeptide binding]; other site 653045007487 active site 653045007488 FMN-binding site [chemical binding]; other site 653045007489 Shikimate kinase; Region: SKI; pfam01202 653045007490 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 653045007491 ADP binding site [chemical binding]; other site 653045007492 magnesium binding site [ion binding]; other site 653045007493 putative shikimate binding site; other site 653045007494 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 653045007495 active site 653045007496 dimer interface [polypeptide binding]; other site 653045007497 metal binding site [ion binding]; metal-binding site 653045007498 AAA domain; Region: AAA_33; pfam13671 653045007499 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007500 active site 653045007501 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 653045007502 active site 653045007503 elongation factor P; Validated; Region: PRK00529 653045007504 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 653045007505 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 653045007506 RNA binding site [nucleotide binding]; other site 653045007507 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 653045007508 RNA binding site [nucleotide binding]; other site 653045007509 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 653045007510 putative RNA binding site [nucleotide binding]; other site 653045007511 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 653045007512 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045007513 non-specific DNA binding site [nucleotide binding]; other site 653045007514 salt bridge; other site 653045007515 sequence-specific DNA binding site [nucleotide binding]; other site 653045007516 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 653045007517 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 653045007518 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 653045007519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007520 dihydroorotase; Validated; Region: pyrC; PRK09357 653045007521 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045007522 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 653045007523 active site 653045007524 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 653045007525 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 653045007526 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 653045007527 catalytic site [active] 653045007528 subunit interface [polypeptide binding]; other site 653045007529 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 653045007530 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 653045007531 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045007532 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 653045007533 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 653045007534 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045007535 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 653045007536 IMP binding site; other site 653045007537 dimer interface [polypeptide binding]; other site 653045007538 interdomain contacts; other site 653045007539 partial ornithine binding site; other site 653045007540 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 653045007541 quinone interaction residues [chemical binding]; other site 653045007542 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 653045007543 active site 653045007544 catalytic residues [active] 653045007545 FMN binding site [chemical binding]; other site 653045007546 substrate binding site [chemical binding]; other site 653045007547 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 653045007548 active site 653045007549 dimer interface [polypeptide binding]; other site 653045007550 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 653045007551 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 653045007552 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 653045007553 catalytic site [active] 653045007554 G-X2-G-X-G-K; other site 653045007555 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 653045007556 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 653045007557 Flavoprotein; Region: Flavoprotein; cl08021 653045007558 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 653045007559 S-adenosylmethionine synthetase; Validated; Region: PRK05250 653045007560 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 653045007561 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 653045007562 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 653045007563 primosome assembly protein PriA; Provisional; Region: PRK14873 653045007564 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 653045007565 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 653045007566 putative active site [active] 653045007567 substrate binding site [chemical binding]; other site 653045007568 putative cosubstrate binding site; other site 653045007569 catalytic site [active] 653045007570 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 653045007571 substrate binding site [chemical binding]; other site 653045007572 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045007573 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007574 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045007575 Walker A/P-loop; other site 653045007576 ATP binding site [chemical binding]; other site 653045007577 Q-loop/lid; other site 653045007578 ABC transporter signature motif; other site 653045007579 Walker B; other site 653045007580 D-loop; other site 653045007581 H-loop/switch region; other site 653045007582 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 653045007583 putative RNA binding site [nucleotide binding]; other site 653045007584 16S rRNA methyltransferase B; Provisional; Region: PRK14902 653045007585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045007586 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045007587 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 653045007588 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 653045007589 substrate binding site [chemical binding]; other site 653045007590 hexamer interface [polypeptide binding]; other site 653045007591 metal binding site [ion binding]; metal-binding site 653045007592 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 653045007593 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 653045007594 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 653045007595 active site 653045007596 zinc binding site [ion binding]; other site 653045007597 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 653045007598 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 653045007599 SpaB C-terminal domain; Region: SpaB_C; cl14828 653045007600 SpaB C-terminal domain; Region: SpaB_C; cl14828 653045007601 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 653045007602 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045007603 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 653045007604 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 653045007605 active site 653045007606 amino acid transporter; Region: 2A0306; TIGR00909 653045007607 Spore germination protein; Region: Spore_permease; cl15802 653045007608 Spore germination protein; Region: Spore_permease; cl15802 653045007609 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045007610 Helix-turn-helix domains; Region: HTH; cl00088 653045007611 Predicted amidohydrolase [General function prediction only]; Region: COG0388 653045007612 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 653045007613 putative active site [active] 653045007614 catalytic triad [active] 653045007615 putative dimer interface [polypeptide binding]; other site 653045007616 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 653045007617 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 653045007618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007619 NAD(P) binding site [chemical binding]; other site 653045007620 active site 653045007621 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 653045007622 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 653045007623 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 653045007624 tetramer interface [polypeptide binding]; other site 653045007625 active site 653045007626 Mg2+/Mn2+ binding site [ion binding]; other site 653045007627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045007628 putative substrate translocation pore; other site 653045007629 Helix-turn-helix domains; Region: HTH; cl00088 653045007630 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045007631 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 653045007632 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 653045007633 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 653045007634 catalytic motif [active] 653045007635 Zn binding site [ion binding]; other site 653045007636 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045007637 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 653045007638 Lumazine binding domain; Region: Lum_binding; pfam00677 653045007639 Lumazine binding domain; Region: Lum_binding; pfam00677 653045007640 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 653045007641 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 653045007642 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 653045007643 dimerization interface [polypeptide binding]; other site 653045007644 active site 653045007645 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 653045007646 homopentamer interface [polypeptide binding]; other site 653045007647 active site 653045007648 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 653045007649 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 653045007650 ATP phosphoribosyltransferase; Region: HisG; cl15266 653045007651 HisG, C-terminal domain; Region: HisG_C; cl06867 653045007652 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 653045007653 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 653045007654 Domain of unknown function DUF21; Region: DUF21; pfam01595 653045007655 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 653045007656 Transporter associated domain; Region: CorC_HlyC; cl08393 653045007657 Domain of unknown function DUF21; Region: DUF21; pfam01595 653045007658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 653045007659 FOG: CBS domain [General function prediction only]; Region: COG0517 653045007660 type VII secretion AAA-ATPase EccA; Region: T7SS_EccA; TIGR03922 653045007661 stage V sporulation protein K; Region: spore_V_K; TIGR02881 653045007662 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045007663 Walker A motif; other site 653045007664 ATP binding site [chemical binding]; other site 653045007665 Walker B motif; other site 653045007666 arginine finger; other site 653045007667 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007668 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 653045007669 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39A; cd02549 653045007670 putative active site [active] 653045007671 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 653045007672 minor groove reading motif; other site 653045007673 helix-hairpin-helix signature motif; other site 653045007674 active site 653045007675 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 653045007676 Helix-turn-helix domains; Region: HTH; cl00088 653045007677 PAS domain S-box; Region: sensory_box; TIGR00229 653045007678 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045007679 putative active site [active] 653045007680 heme pocket [chemical binding]; other site 653045007681 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 653045007682 metal binding site [ion binding]; metal-binding site 653045007683 active site 653045007684 I-site; other site 653045007685 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 653045007686 Protein of unknown function (DUF779); Region: DUF779; cl01432 653045007687 hypothetical protein; Provisional; Region: PRK08244 653045007688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007689 tetracycline repressor protein TetR; Provisional; Region: PRK13756 653045007690 Helix-turn-helix domains; Region: HTH; cl00088 653045007691 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045007692 Helix-turn-helix domains; Region: HTH; cl00088 653045007693 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 653045007694 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 653045007695 substrate binding pocket [chemical binding]; other site 653045007696 active site 653045007697 iron coordination sites [ion binding]; other site 653045007698 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045007699 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045007700 peptide synthase; Provisional; Region: PRK12316 653045007701 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007702 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007703 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007704 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045007705 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007706 peptide synthase; Validated; Region: PRK05691 653045007707 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007708 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045007709 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007710 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007711 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045007712 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007713 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007714 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007715 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 653045007716 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045007717 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045007719 S-adenosylmethionine binding site [chemical binding]; other site 653045007720 peptide synthase; Provisional; Region: PRK12467 653045007721 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007722 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045007723 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007724 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007725 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007726 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 653045007727 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007728 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007729 Condensation domain; Region: Condensation; pfam00668 653045007730 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045007731 peptide synthase; Provisional; Region: PRK12316 653045007732 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007733 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007734 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045007735 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045007736 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007737 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007738 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045007739 AMP-binding enzyme; Region: AMP-binding; cl15778 653045007740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045007741 S-adenosylmethionine binding site [chemical binding]; other site 653045007742 peptide synthase; Provisional; Region: PRK12467 653045007743 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045007744 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045007745 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007746 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045007747 Walker A/P-loop; other site 653045007748 ATP binding site [chemical binding]; other site 653045007749 Q-loop/lid; other site 653045007750 ABC transporter signature motif; other site 653045007751 Walker B; other site 653045007752 D-loop; other site 653045007753 H-loop/switch region; other site 653045007754 DsrE/DsrF-like family; Region: DrsE; cl00672 653045007755 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007756 short chain dehydrogenase; Provisional; Region: PRK06197 653045007757 NAD(P) binding site [chemical binding]; other site 653045007758 active site 653045007759 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 653045007760 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045007761 S-adenosylmethionine binding site [chemical binding]; other site 653045007762 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 653045007763 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 653045007764 active site 653045007765 catalytic site [active] 653045007766 substrate binding site [chemical binding]; other site 653045007767 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045007768 putative metal binding site [ion binding]; other site 653045007769 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 653045007770 Di-iron ligands [ion binding]; other site 653045007771 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 653045007772 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045007773 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 653045007774 active site 653045007775 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045007776 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045007777 NAD(P) binding site [chemical binding]; other site 653045007778 catalytic residues [active] 653045007779 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 653045007780 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 653045007781 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 653045007782 Glyco_18 domain; Region: Glyco_18; smart00636 653045007783 active site 653045007784 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045007785 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045007786 active site 653045007787 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045007788 Helix-turn-helix domains; Region: HTH; cl00088 653045007789 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 653045007790 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045007791 active site 653045007792 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 653045007793 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 653045007794 putative active site [active] 653045007795 catalytic triad [active] 653045007796 putative dimer interface [polypeptide binding]; other site 653045007797 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 653045007798 Ligand binding site; other site 653045007799 Putative Catalytic site; other site 653045007800 DXD motif; other site 653045007801 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 653045007802 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 653045007803 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 653045007804 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 653045007805 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 653045007806 Predicted membrane protein [Function unknown]; Region: COG2364 653045007807 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 653045007808 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 653045007809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045007810 DNA-binding site [nucleotide binding]; DNA binding site 653045007811 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045007812 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045007813 homodimer interface [polypeptide binding]; other site 653045007814 catalytic residue [active] 653045007815 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007816 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045007817 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 653045007818 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 653045007819 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045007820 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045007821 Helix-turn-helix domains; Region: HTH; cl00088 653045007822 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045007823 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045007824 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 653045007825 active site 653045007826 catalytic residues [active] 653045007827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045007828 putative substrate translocation pore; other site 653045007829 Cupin domain; Region: Cupin_2; cl09118 653045007830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045007831 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045007832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045007833 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 653045007834 Amidase; Region: Amidase; cl11426 653045007835 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 653045007836 catalytic triad [active] 653045007837 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045007838 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 653045007839 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045007840 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045007841 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 653045007842 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045007843 D-allose kinase; Provisional; Region: PRK09698 653045007844 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 653045007845 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045007846 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 653045007847 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 653045007848 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 653045007849 Cysteine-rich domain; Region: CCG; pfam02754 653045007850 Cysteine-rich domain; Region: CCG; pfam02754 653045007851 L-rhamnulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 653045007852 N- and C-terminal domain interface [polypeptide binding]; other site 653045007853 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 653045007854 active site 653045007855 catalytic site [active] 653045007856 metal binding site [ion binding]; metal-binding site 653045007857 ATP binding site [chemical binding]; other site 653045007858 carbohydrate binding site [chemical binding]; other site 653045007859 short chain dehydrogenase; Validated; Region: PRK08324 653045007860 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 653045007861 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 653045007862 putative NAD(P) binding site [chemical binding]; other site 653045007863 active site 653045007864 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 653045007865 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 653045007866 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 653045007867 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 653045007868 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 653045007869 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045007870 Walker A/P-loop; other site 653045007871 ATP binding site [chemical binding]; other site 653045007872 Q-loop/lid; other site 653045007873 ABC transporter signature motif; other site 653045007874 Walker B; other site 653045007875 D-loop; other site 653045007876 H-loop/switch region; other site 653045007877 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 653045007878 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045007879 TM-ABC transporter signature motif; other site 653045007880 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045007881 TM-ABC transporter signature motif; other site 653045007882 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 653045007883 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 653045007884 ligand binding site [chemical binding]; other site 653045007885 Domain of unknown function (DUF718); Region: DUF718; cl01281 653045007886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045007887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045007888 DNA binding site [nucleotide binding] 653045007889 domain linker motif; other site 653045007890 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045007891 dimerization interface [polypeptide binding]; other site 653045007892 ligand binding site [chemical binding]; other site 653045007893 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045007894 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045007895 DNA binding site [nucleotide binding] 653045007896 domain linker motif; other site 653045007897 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045007898 dimerization interface [polypeptide binding]; other site 653045007899 ligand binding site [chemical binding]; other site 653045007900 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045007901 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045007902 Probable transposase; Region: OrfB_IS605; pfam01385 653045007903 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045007904 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 653045007905 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007906 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 653045007907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045007908 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045007909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045007910 S-adenosylmethionine binding site [chemical binding]; other site 653045007911 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045007912 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045007913 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045007914 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045007915 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045007916 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007917 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045007918 Walker A/P-loop; other site 653045007919 ATP binding site [chemical binding]; other site 653045007920 Q-loop/lid; other site 653045007921 ABC transporter signature motif; other site 653045007922 Walker B; other site 653045007923 D-loop; other site 653045007924 H-loop/switch region; other site 653045007925 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 653045007926 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 653045007927 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 653045007928 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 653045007929 Ligand Binding Site [chemical binding]; other site 653045007930 Molecular Tunnel; other site 653045007931 Helix-turn-helix domains; Region: HTH; cl00088 653045007932 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045007933 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045007934 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045007935 TPR motif; other site 653045007936 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045007937 binding surface 653045007938 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045007939 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045007940 binding surface 653045007941 TPR motif; other site 653045007942 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045007943 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 653045007944 putative active site [active] 653045007945 putative metal binding site [ion binding]; other site 653045007946 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 653045007947 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045007948 Helix-turn-helix domains; Region: HTH; cl00088 653045007949 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045007950 dimerization interface [polypeptide binding]; other site 653045007951 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 653045007952 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045007953 putative NAD(P) binding site [chemical binding]; other site 653045007954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045007955 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045007956 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045007957 acetaldehyde dehydrogenase; Validated; Region: PRK08300 653045007958 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045007959 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 653045007960 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 653045007961 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 653045007962 active site 653045007963 catalytic residues [active] 653045007964 metal binding site [ion binding]; metal-binding site 653045007965 DmpG-like communication domain; Region: DmpG_comm; pfam07836 653045007966 tetracycline repressor protein TetR; Provisional; Region: PRK13756 653045007967 Helix-turn-helix domains; Region: HTH; cl00088 653045007968 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045007969 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045007970 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045007971 putative substrate translocation pore; other site 653045007972 5,10-methylenetetrahydromethanopterin reductase; Region: F420_mer; TIGR03555 653045007973 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045007974 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 653045007975 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045007976 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045007977 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 653045007978 Cellulose binding domain; Region: CBM_2; cl02709 653045007979 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045007980 Carboxylesterase family; Region: COesterase; pfam00135 653045007981 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045007982 substrate binding pocket [chemical binding]; other site 653045007983 catalytic triad [active] 653045007984 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045007985 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 653045007986 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 653045007987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045007988 dimer interface [polypeptide binding]; other site 653045007989 conserved gate region; other site 653045007990 putative PBP binding loops; other site 653045007991 ABC-ATPase subunit interface; other site 653045007992 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045007993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045007994 putative PBP binding loops; other site 653045007995 dimer interface [polypeptide binding]; other site 653045007996 ABC-ATPase subunit interface; other site 653045007997 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045007998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045007999 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045008000 ligand binding site [chemical binding]; other site 653045008001 dimerization interface [polypeptide binding]; other site 653045008002 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045008003 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 653045008004 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045008005 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045008006 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045008007 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 653045008008 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045008009 Walker A/P-loop; other site 653045008010 ATP binding site [chemical binding]; other site 653045008011 Q-loop/lid; other site 653045008012 ABC transporter signature motif; other site 653045008013 Walker B; other site 653045008014 D-loop; other site 653045008015 H-loop/switch region; other site 653045008016 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045008017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008018 dimer interface [polypeptide binding]; other site 653045008019 conserved gate region; other site 653045008020 putative PBP binding loops; other site 653045008021 ABC-ATPase subunit interface; other site 653045008022 amidase; Provisional; Region: PRK08137 653045008023 Amidase; Region: Amidase; cl11426 653045008024 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045008025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008026 NAD(P) binding site [chemical binding]; other site 653045008027 active site 653045008028 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045008029 active site 653045008030 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 653045008031 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045008032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045008033 catalytic residue [active] 653045008034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045008035 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 653045008036 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008037 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008038 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 653045008039 ligand binding site [chemical binding]; other site 653045008040 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045008041 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045008042 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045008043 acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946 653045008044 Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007 653045008045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008046 NAD(P) binding site [chemical binding]; other site 653045008047 active site 653045008048 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045008049 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045008050 active site 653045008051 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045008052 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045008053 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045008054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045008055 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008056 Enoylreductase; Region: PKS_ER; smart00829 653045008057 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045008058 NAD(P) binding site [chemical binding]; other site 653045008059 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 653045008060 putative NADP binding site [chemical binding]; other site 653045008061 active site 653045008062 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045008063 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 653045008064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045008065 dimerization interface [polypeptide binding]; other site 653045008066 poly-gamma-glutamate synthase PgsB/CapB; Region: poly_gGlu_PgsB; TIGR04012 653045008067 cell division protein ZipA; Provisional; Region: PRK03427 653045008068 Capsule biosynthesis CapC; Region: Caps_synth_CapC; cl14855 653045008069 NlpC/P60 family; Region: NLPC_P60; cl11438 653045008070 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 653045008071 metal binding site 2 [ion binding]; metal-binding site 653045008072 putative DNA binding helix; other site 653045008073 metal binding site 1 [ion binding]; metal-binding site 653045008074 dimer interface [polypeptide binding]; other site 653045008075 structural Zn2+ binding site [ion binding]; other site 653045008076 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 653045008077 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 653045008078 dimer interface [polypeptide binding]; other site 653045008079 active site 653045008080 heme binding site [chemical binding]; other site 653045008081 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 653045008082 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 653045008083 active site 653045008084 putative catalytic site [active] 653045008085 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045008086 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045008087 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045008088 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 653045008089 Sodium:solute symporter family; Region: SSF; cl00456 653045008090 Protein of unknown function, DUF485; Region: DUF485; cl01231 653045008091 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 653045008092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045008093 putative substrate translocation pore; other site 653045008094 Nitrate and nitrite sensing; Region: NIT; pfam08376 653045008095 sensory histidine kinase CreC; Provisional; Region: PRK11100 653045008096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045008097 ATP binding site [chemical binding]; other site 653045008098 Mg2+ binding site [ion binding]; other site 653045008099 G-X-G motif; other site 653045008100 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045008101 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045008102 TM1410 hypothetical-related protein; Region: DUF297; cl00997 653045008103 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045008104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045008105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008106 dimer interface [polypeptide binding]; other site 653045008107 conserved gate region; other site 653045008108 putative PBP binding loops; other site 653045008109 ABC-ATPase subunit interface; other site 653045008110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008111 dimer interface [polypeptide binding]; other site 653045008112 conserved gate region; other site 653045008113 putative PBP binding loops; other site 653045008114 ABC-ATPase subunit interface; other site 653045008115 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045008116 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 653045008117 substrate binding site [chemical binding]; other site 653045008118 ATP binding site [chemical binding]; other site 653045008119 alpha-galactosidase; Provisional; Region: PRK15076 653045008120 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 653045008121 NAD binding site [chemical binding]; other site 653045008122 sugar binding site [chemical binding]; other site 653045008123 divalent metal binding site [ion binding]; other site 653045008124 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 653045008125 dimer interface [polypeptide binding]; other site 653045008126 NIPSNAP; Region: NIPSNAP; pfam07978 653045008127 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045008128 Helix-turn-helix domains; Region: HTH; cl00088 653045008129 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 653045008130 active site 653045008131 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 653045008132 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045008133 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045008134 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045008135 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 653045008136 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045008137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045008138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045008139 non-specific DNA binding site [nucleotide binding]; other site 653045008140 salt bridge; other site 653045008141 sequence-specific DNA binding site [nucleotide binding]; other site 653045008142 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045008143 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045008144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045008145 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045008146 putative substrate translocation pore; other site 653045008147 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 653045008148 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045008149 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045008150 DNA binding site [nucleotide binding] 653045008151 domain linker motif; other site 653045008152 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045008153 ligand binding site [chemical binding]; other site 653045008154 dimerization interface [polypeptide binding]; other site 653045008155 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 653045008156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045008157 active site 653045008158 phosphorylation site [posttranslational modification] 653045008159 intermolecular recognition site; other site 653045008160 dimerization interface [polypeptide binding]; other site 653045008161 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045008162 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045008163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045008164 ATP binding site [chemical binding]; other site 653045008165 Mg2+ binding site [ion binding]; other site 653045008166 G-X-G motif; other site 653045008167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 653045008168 NMT1-like family; Region: NMT1_2; cl15260 653045008169 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 653045008170 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 653045008171 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 653045008172 N- and C-terminal domain interface [polypeptide binding]; other site 653045008173 D-xylulose kinase; Region: XylB; TIGR01312 653045008174 putative active site [active] 653045008175 catalytic site [active] 653045008176 metal binding site [ion binding]; metal-binding site 653045008177 putative xylulose binding site [chemical binding]; other site 653045008178 putative ATP binding site [chemical binding]; other site 653045008179 putative homodimer interface [polypeptide binding]; other site 653045008180 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 653045008181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008182 NAD(P) binding site [chemical binding]; other site 653045008183 active site 653045008184 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 653045008185 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 653045008186 putative active site [active] 653045008187 putative substrate binding site [chemical binding]; other site 653045008188 ATP binding site [chemical binding]; other site 653045008189 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045008190 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045008191 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 653045008192 active site 653045008193 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045008194 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045008195 putative substrate translocation pore; other site 653045008196 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045008197 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008198 NAD(P) binding site [chemical binding]; other site 653045008199 active site 653045008200 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 653045008201 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 653045008202 NAD binding site [chemical binding]; other site 653045008203 substrate binding site [chemical binding]; other site 653045008204 catalytic Zn binding site [ion binding]; other site 653045008205 structural Zn binding site [ion binding]; other site 653045008206 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045008207 classical (c) SDRs; Region: SDR_c; cd05233 653045008208 NAD(P) binding site [chemical binding]; other site 653045008209 active site 653045008210 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 653045008211 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045008212 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045008213 active site 653045008214 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 653045008215 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045008216 substrate binding site [chemical binding]; other site 653045008217 oxyanion hole (OAH) forming residues; other site 653045008218 trimer interface [polypeptide binding]; other site 653045008219 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 653045008220 DUF35 OB-fold domain; Region: DUF35; pfam01796 653045008221 lipid-transfer protein; Provisional; Region: PRK08256 653045008222 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 653045008223 active site 653045008224 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045008225 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045008226 active site 653045008227 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 653045008228 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 653045008229 putative active site [active] 653045008230 putative substrate binding site [chemical binding]; other site 653045008231 ATP binding site [chemical binding]; other site 653045008232 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045008233 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045008234 active site 653045008235 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045008236 classical (c) SDRs; Region: SDR_c; cd05233 653045008237 NAD(P) binding site [chemical binding]; other site 653045008238 active site 653045008239 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 653045008240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008241 NAD(P) binding site [chemical binding]; other site 653045008242 active site 653045008243 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045008244 enoyl-CoA hydratase; Provisional; Region: PRK06688 653045008245 substrate binding site [chemical binding]; other site 653045008246 oxyanion hole (OAH) forming residues; other site 653045008247 trimer interface [polypeptide binding]; other site 653045008248 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 653045008249 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045008250 dimer interface [polypeptide binding]; other site 653045008251 active site 653045008252 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045008253 Helix-turn-helix domains; Region: HTH; cl00088 653045008254 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 653045008255 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045008256 AMP-binding enzyme; Region: AMP-binding; cl15778 653045008257 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045008258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045008259 Methyltransferase domain; Region: Methyltransf_31; pfam13847 653045008260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045008261 S-adenosylmethionine binding site [chemical binding]; other site 653045008262 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045008263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045008264 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 653045008265 catalytic triad [active] 653045008266 phosphoethanolamine N-methyltransferase; Region: PLN02336 653045008267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045008268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045008269 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 653045008270 tellurite resistance protein terB; Region: terB; cd07176 653045008271 putative metal binding site [ion binding]; other site 653045008272 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045008273 dimerization interface [polypeptide binding]; other site 653045008274 putative DNA binding site [nucleotide binding]; other site 653045008275 putative Zn2+ binding site [ion binding]; other site 653045008276 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 653045008277 DNA binding residues [nucleotide binding] 653045008278 dimer interface [polypeptide binding]; other site 653045008279 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045008280 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 653045008281 homotrimer interaction site [polypeptide binding]; other site 653045008282 putative active site [active] 653045008283 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045008284 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045008285 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045008286 conserved cys residue [active] 653045008287 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045008288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045008289 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045008290 Helix-turn-helix domains; Region: HTH; cl00088 653045008291 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 653045008292 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 653045008293 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008294 NAD(P) binding pocket [chemical binding]; other site 653045008295 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 653045008296 putative dimer interface [polypeptide binding]; other site 653045008297 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045008298 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 653045008299 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Y4yA; Region: PLPDE_III_Y4yA_like; cd06842 653045008300 dimer interface [polypeptide binding]; other site 653045008301 active site 653045008302 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045008303 catalytic residues [active] 653045008304 substrate binding site [chemical binding]; other site 653045008305 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 653045008306 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 653045008307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045008308 catalytic residue [active] 653045008309 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 653045008310 active site residue [active] 653045008311 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 653045008312 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045008313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045008314 catalytic residue [active] 653045008315 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045008316 S-adenosylmethionine binding site [chemical binding]; other site 653045008317 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045008318 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 653045008319 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008320 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 653045008321 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 653045008322 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 653045008323 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 653045008324 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 653045008325 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 653045008326 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 653045008327 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 653045008328 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 653045008329 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 653045008330 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 653045008331 Helix-turn-helix domains; Region: HTH; cl00088 653045008332 Predicted permeases [General function prediction only]; Region: COG0701 653045008333 Predicted permease; Region: DUF318; pfam03773 653045008334 Predicted permease; Region: DUF318; pfam03773 653045008335 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 653045008336 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045008337 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045008338 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045008339 active site 653045008340 phosphorylation site [posttranslational modification] 653045008341 intermolecular recognition site; other site 653045008342 dimerization interface [polypeptide binding]; other site 653045008343 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045008344 DNA binding site [nucleotide binding] 653045008345 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 653045008346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045008347 dimer interface [polypeptide binding]; other site 653045008348 phosphorylation site [posttranslational modification] 653045008349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045008350 ATP binding site [chemical binding]; other site 653045008351 Mg2+ binding site [ion binding]; other site 653045008352 G-X-G motif; other site 653045008353 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045008354 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045008355 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045008356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045008357 Helix-turn-helix domains; Region: HTH; cl00088 653045008358 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045008359 dimerization interface [polypeptide binding]; other site 653045008360 substrate binding pocket [chemical binding]; other site 653045008361 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008362 active site 653045008363 oxidoreductase; Provisional; Region: PRK06196 653045008364 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 653045008365 putative NAD(P) binding site [chemical binding]; other site 653045008366 active site 653045008367 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 653045008368 active site 653045008369 catalytic triad [active] 653045008370 oxyanion hole [active] 653045008371 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 653045008372 putative ligand binding site [chemical binding]; other site 653045008373 putative catalytic site [active] 653045008374 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 653045008375 active site 653045008376 catalytic triad [active] 653045008377 oxyanion hole [active] 653045008378 Helix-turn-helix domains; Region: HTH; cl00088 653045008379 Helix-turn-helix domains; Region: HTH; cl00088 653045008380 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045008381 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045008382 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 653045008383 putative metal binding site [ion binding]; other site 653045008384 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 653045008385 Right handed beta helix region; Region: Beta_helix; pfam13229 653045008386 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 653045008387 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045008388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008389 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045008390 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 653045008391 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 653045008392 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 653045008393 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 653045008394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008396 dimer interface [polypeptide binding]; other site 653045008397 conserved gate region; other site 653045008398 ABC-ATPase subunit interface; other site 653045008399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008400 dimer interface [polypeptide binding]; other site 653045008401 conserved gate region; other site 653045008402 putative PBP binding loops; other site 653045008403 ABC-ATPase subunit interface; other site 653045008404 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045008405 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 653045008406 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 653045008407 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 653045008408 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 653045008409 Helix-turn-helix domains; Region: HTH; cl00088 653045008410 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045008411 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045008412 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 653045008413 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045008414 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045008415 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045008416 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 653045008417 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 653045008418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045008419 short chain dehydrogenase; Provisional; Region: PRK06914 653045008420 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045008421 NADP binding site [chemical binding]; other site 653045008422 active site 653045008423 steroid binding site; other site 653045008424 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045008425 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045008426 putative active site [active] 653045008427 heme pocket [chemical binding]; other site 653045008428 PAS fold; Region: PAS_4; pfam08448 653045008429 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045008430 putative active site [active] 653045008431 heme pocket [chemical binding]; other site 653045008432 GAF domain; Region: GAF_2; pfam13185 653045008433 GAF domain; Region: GAF; cl15785 653045008434 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045008435 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045008436 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 653045008437 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 653045008438 NAD binding site [chemical binding]; other site 653045008439 catalytic Zn binding site [ion binding]; other site 653045008440 structural Zn binding site [ion binding]; other site 653045008441 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 653045008442 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 653045008443 dimer interface [polypeptide binding]; other site 653045008444 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 653045008445 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 653045008446 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 653045008447 HSP70 interaction site [polypeptide binding]; other site 653045008448 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 653045008449 substrate binding site [polypeptide binding]; other site 653045008450 dimer interface [polypeptide binding]; other site 653045008451 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 653045008452 Clp amino terminal domain; Region: Clp_N; pfam02861 653045008453 Clp amino terminal domain; Region: Clp_N; pfam02861 653045008454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045008455 Walker A motif; other site 653045008456 ATP binding site [chemical binding]; other site 653045008457 Walker B motif; other site 653045008458 arginine finger; other site 653045008459 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045008460 Walker A motif; other site 653045008461 ATP binding site [chemical binding]; other site 653045008462 Walker B motif; other site 653045008463 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 653045008464 thioredoxin 2; Provisional; Region: PRK10996 653045008465 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 653045008466 catalytic residues [active] 653045008467 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 653045008468 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045008469 ligand binding site [chemical binding]; other site 653045008470 flexible hinge region; other site 653045008471 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 653045008472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008473 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045008474 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 653045008475 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 653045008476 putative dimer interface [polypeptide binding]; other site 653045008477 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045008478 Domain of unknown function (DUF1931); Region: DUF1931; pfam09123 653045008479 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 653045008480 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 653045008481 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 653045008482 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045008483 active site 653045008484 Transmembrane secretion effector; Region: MFS_3; pfam05977 653045008485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008486 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045008487 NAD(P) binding site [chemical binding]; other site 653045008488 active site 653045008489 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 653045008490 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 653045008491 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045008492 active site 653045008493 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045008494 active site 653045008495 motif I; other site 653045008496 motif II; other site 653045008497 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 653045008498 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045008499 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 653045008500 putative active site [active] 653045008501 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045008502 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 653045008503 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 653045008504 putative ADP-binding pocket [chemical binding]; other site 653045008505 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 653045008506 dimer interface [polypeptide binding]; other site 653045008507 active site 653045008508 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 653045008509 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 653045008510 substrate binding site [chemical binding]; other site 653045008511 ATP binding site [chemical binding]; other site 653045008512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045008513 active site 653045008514 HIGH motif; other site 653045008515 nucleotide binding site [chemical binding]; other site 653045008516 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 653045008517 putative active site [active] 653045008518 oxidoreductase; Provisional; Region: PRK12743 653045008519 classical (c) SDRs; Region: SDR_c; cd05233 653045008520 NAD(P) binding site [chemical binding]; other site 653045008521 active site 653045008522 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045008523 active site 653045008524 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 653045008525 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045008526 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045008527 active site 653045008528 catalytic tetrad [active] 653045008529 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045008530 NAD(P) binding site [chemical binding]; other site 653045008531 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 653045008532 Cupin domain; Region: Cupin_2; cl09118 653045008533 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045008534 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045008535 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045008536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045008537 Flavin Reductases; Region: FlaRed; cl00801 653045008538 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 653045008539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045008540 motif II; other site 653045008541 Bacitracin resistance protein BacA; Region: BacA; cl00858 653045008542 benzoate transport; Region: 2A0115; TIGR00895 653045008543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045008544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045008545 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045008546 elongation factor Tu; Reviewed; Region: PRK12736 653045008547 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 653045008548 G1 box; other site 653045008549 GEF interaction site [polypeptide binding]; other site 653045008550 GTP/Mg2+ binding site [chemical binding]; other site 653045008551 Switch I region; other site 653045008552 G2 box; other site 653045008553 G3 box; other site 653045008554 Switch II region; other site 653045008555 G4 box; other site 653045008556 G5 box; other site 653045008557 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 653045008558 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 653045008559 Antibiotic Binding Site [chemical binding]; other site 653045008560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045008561 S-adenosylmethionine binding site [chemical binding]; other site 653045008562 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045008563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 653045008564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 653045008565 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 653045008566 CoenzymeA binding site [chemical binding]; other site 653045008567 subunit interaction site [polypeptide binding]; other site 653045008568 PHB binding site; other site 653045008569 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045008570 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 653045008571 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 653045008572 trimer interface [polypeptide binding]; other site 653045008573 putative metal binding site [ion binding]; other site 653045008574 GAF domain; Region: GAF_2; pfam13185 653045008575 ANTAR domain; Region: ANTAR; cl04297 653045008576 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045008577 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 653045008578 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 653045008579 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045008580 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045008581 Predicted membrane protein [Function unknown]; Region: COG4129 653045008582 EamA-like transporter family; Region: EamA; cl01037 653045008583 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 653045008584 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045008585 non-specific DNA binding site [nucleotide binding]; other site 653045008586 salt bridge; other site 653045008587 sequence-specific DNA binding site [nucleotide binding]; other site 653045008588 Cupin domain; Region: Cupin_2; cl09118 653045008589 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 653045008590 putative deacylase active site [active] 653045008591 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045008592 Helix-turn-helix domains; Region: HTH; cl00088 653045008593 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045008594 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045008595 NAD(P) binding site [chemical binding]; other site 653045008596 phenylalanyl-tRNA synthetase subunit alpha; Provisional; Region: pheS; PRK04172 653045008597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008598 Transposase domain (DUF772); Region: DUF772; pfam05598 653045008599 Integrase core domain; Region: rve; cl01316 653045008600 Integrase core domain; Region: rve_3; cl15866 653045008601 Leucine carboxyl methyltransferase; Region: LCM; cl01306 653045008602 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 653045008603 Helix-turn-helix domains; Region: HTH; cl00088 653045008604 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045008605 dimerization interface [polypeptide binding]; other site 653045008606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008607 NAD(P) binding site [chemical binding]; other site 653045008608 active site 653045008609 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 653045008610 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 653045008611 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 653045008612 DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420 653045008613 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 653045008614 active site 653045008615 metal binding site [ion binding]; metal-binding site 653045008616 DNA binding site [nucleotide binding] 653045008617 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 653045008618 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008619 Walker A/P-loop; other site 653045008620 ATP binding site [chemical binding]; other site 653045008621 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008622 Q-loop/lid; other site 653045008623 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008624 ABC transporter signature motif; other site 653045008625 Walker B; other site 653045008626 D-loop; other site 653045008627 H-loop/switch region; other site 653045008628 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045008629 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 653045008630 Helix-turn-helix domains; Region: HTH; cl00088 653045008631 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 653045008632 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045008633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045008634 catalytic residue [active] 653045008635 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 653045008636 Phosphodiesterase/alkaline phosphatase D [Inorganic ion transport and metabolism]; Region: PhoD; COG3540 653045008637 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 653045008638 putative active site [active] 653045008639 putative metal binding site [ion binding]; other site 653045008640 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045008641 short chain dehydrogenase; Provisional; Region: PRK06123 653045008642 classical (c) SDRs; Region: SDR_c; cd05233 653045008643 NAD(P) binding site [chemical binding]; other site 653045008644 active site 653045008645 Helix-turn-helix domains; Region: HTH; cl00088 653045008646 DNA-binding site [nucleotide binding]; DNA binding site 653045008647 UTRA domain; Region: UTRA; cl01230 653045008648 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045008649 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045008650 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 653045008651 active site 653045008652 SUMO-1 interface [polypeptide binding]; other site 653045008653 adenylosuccinate lyase; Region: purB; TIGR00928 653045008654 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 653045008655 tetramer interface [polypeptide binding]; other site 653045008656 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 653045008657 active site 653045008658 catalytic triad [active] 653045008659 oxyanion hole [active] 653045008660 Domain of unknown function DUF21; Region: DUF21; pfam01595 653045008661 FOG: CBS domain [General function prediction only]; Region: COG0517 653045008662 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 653045008663 Domain of unknown function DUF21; Region: DUF21; pfam01595 653045008664 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 653045008665 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 653045008666 Transporter associated domain; Region: CorC_HlyC; cl08393 653045008667 putative acetyltransferase; Provisional; Region: PRK03624 653045008668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045008669 Coenzyme A binding pocket [chemical binding]; other site 653045008670 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 653045008671 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045008672 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045008673 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045008674 Walker A/P-loop; other site 653045008675 ATP binding site [chemical binding]; other site 653045008676 Q-loop/lid; other site 653045008677 ABC transporter signature motif; other site 653045008678 Walker B; other site 653045008679 D-loop; other site 653045008680 H-loop/switch region; other site 653045008681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045008682 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008683 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 653045008684 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045008685 inhibitor-cofactor binding pocket; inhibition site 653045008686 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045008687 catalytic residue [active] 653045008688 biotin synthase; Validated; Region: PRK06256 653045008689 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045008690 FeS/SAM binding site; other site 653045008691 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 653045008692 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 653045008693 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045008694 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045008695 catalytic residue [active] 653045008696 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045008697 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045008698 non-specific DNA binding site [nucleotide binding]; other site 653045008699 salt bridge; other site 653045008700 sequence-specific DNA binding site [nucleotide binding]; other site 653045008701 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045008702 ATP binding site [chemical binding]; other site 653045008703 Mg2+ binding site [ion binding]; other site 653045008704 G-X-G motif; other site 653045008705 cyclase homology domain; Region: CHD; cd07302 653045008706 nucleotidyl binding site; other site 653045008707 metal binding site [ion binding]; metal-binding site 653045008708 dimer interface [polypeptide binding]; other site 653045008709 NlpC/P60 family; Region: NLPC_P60; cl11438 653045008710 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 653045008711 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 653045008712 oligomer interface [polypeptide binding]; other site 653045008713 active site residues [active] 653045008714 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 653045008715 M28 Zn-peptidase Streptomyces griseus Aminopeptidase and similar proteins; Region: M28_SGAP_like; cd03876 653045008716 active site 653045008717 metal binding site [ion binding]; metal-binding site 653045008718 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 653045008719 alpha-gamma subunit interface [polypeptide binding]; other site 653045008720 beta-gamma subunit interface [polypeptide binding]; other site 653045008721 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 653045008722 gamma-beta subunit interface [polypeptide binding]; other site 653045008723 alpha-beta subunit interface [polypeptide binding]; other site 653045008724 urease subunit alpha; Reviewed; Region: ureC; PRK13206 653045008725 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 653045008726 subunit interactions [polypeptide binding]; other site 653045008727 active site 653045008728 flap region; other site 653045008729 UreF; Region: UreF; pfam01730 653045008730 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008731 UreD urease accessory protein; Region: UreD; cl00530 653045008732 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045008733 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045008734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008735 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045008736 NAD(P) binding site [chemical binding]; other site 653045008737 active site 653045008738 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 653045008739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045008740 ATP binding site [chemical binding]; other site 653045008741 Mg2+ binding site [ion binding]; other site 653045008742 G-X-G motif; other site 653045008743 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 653045008744 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045008745 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045008746 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 653045008747 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045008748 G2 box; other site 653045008749 Switch I region; other site 653045008750 G3 box; other site 653045008751 Switch II region; other site 653045008752 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045008753 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 653045008754 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 653045008755 active site 653045008756 ADP/pyrophosphate binding site [chemical binding]; other site 653045008757 dimerization interface [polypeptide binding]; other site 653045008758 allosteric effector site; other site 653045008759 fructose-1,6-bisphosphate binding site; other site 653045008760 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 653045008761 catalytic triad [active] 653045008762 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 653045008763 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 653045008764 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 653045008765 active site 653045008766 catalytic residues [active] 653045008767 metal binding site [ion binding]; metal-binding site 653045008768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045008769 Helix-turn-helix domains; Region: HTH; cl00088 653045008770 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045008771 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045008772 active site 653045008773 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 653045008774 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 653045008775 catalytic residue [active] 653045008776 putative FPP diphosphate binding site; other site 653045008777 putative FPP binding hydrophobic cleft; other site 653045008778 dimer interface [polypeptide binding]; other site 653045008779 putative IPP diphosphate binding site; other site 653045008780 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045008781 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045008782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045008783 non-specific DNA binding site [nucleotide binding]; other site 653045008784 salt bridge; other site 653045008785 sequence-specific DNA binding site [nucleotide binding]; other site 653045008786 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045008787 classical (c) SDRs; Region: SDR_c; cd05233 653045008788 NAD(P) binding site [chemical binding]; other site 653045008789 active site 653045008790 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 653045008791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045008792 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045008793 Helix-turn-helix domains; Region: HTH; cl00088 653045008794 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 653045008795 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045008796 PAS fold; Region: PAS_3; pfam08447 653045008797 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045008798 PAS fold; Region: PAS_4; pfam08448 653045008799 GAF domain; Region: GAF; cl15785 653045008800 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045008801 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 653045008802 active site 653045008803 homotetramer interface [polypeptide binding]; other site 653045008804 homodimer interface [polypeptide binding]; other site 653045008805 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045008806 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045008807 conserved cys residue [active] 653045008808 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045008809 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 653045008810 nucleotide binding site [chemical binding]; other site 653045008811 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 653045008812 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 653045008813 active site 653045008814 DNA binding site [nucleotide binding] 653045008815 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 653045008816 DNA binding site [nucleotide binding] 653045008817 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045008818 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045008819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045008820 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045008821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045008822 DNA binding residues [nucleotide binding] 653045008823 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 653045008824 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045008825 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045008826 substrate binding pocket [chemical binding]; other site 653045008827 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045008828 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045008829 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045008830 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008831 Walker A/P-loop; other site 653045008832 ATP binding site [chemical binding]; other site 653045008833 Q-loop/lid; other site 653045008834 ABC transporter signature motif; other site 653045008835 Walker B; other site 653045008836 D-loop; other site 653045008837 H-loop/switch region; other site 653045008838 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045008839 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045008840 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045008841 Walker A/P-loop; other site 653045008842 ATP binding site [chemical binding]; other site 653045008843 Q-loop/lid; other site 653045008844 ABC transporter signature motif; other site 653045008845 Walker B; other site 653045008846 D-loop; other site 653045008847 H-loop/switch region; other site 653045008848 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045008849 Helix-turn-helix domains; Region: HTH; cl00088 653045008850 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045008851 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 653045008852 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 653045008853 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 653045008854 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045008855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045008856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008857 dimer interface [polypeptide binding]; other site 653045008858 conserved gate region; other site 653045008859 ABC-ATPase subunit interface; other site 653045008860 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 653045008861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045008862 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045008863 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 653045008864 Walker A/P-loop; other site 653045008865 ATP binding site [chemical binding]; other site 653045008866 Q-loop/lid; other site 653045008867 ABC transporter signature motif; other site 653045008868 Walker B; other site 653045008869 D-loop; other site 653045008870 H-loop/switch region; other site 653045008871 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045008872 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 653045008873 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045008874 Walker A/P-loop; other site 653045008875 ATP binding site [chemical binding]; other site 653045008876 Q-loop/lid; other site 653045008877 ABC transporter signature motif; other site 653045008878 Walker B; other site 653045008879 D-loop; other site 653045008880 H-loop/switch region; other site 653045008881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045008882 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045008883 active site 653045008884 catalytic tetrad [active] 653045008885 BNR repeat-like domain; Region: BNR_2; pfam13088 653045008886 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 653045008887 Asp-box motif; other site 653045008888 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045008889 classical (c) SDRs; Region: SDR_c; cd05233 653045008890 NAD(P) binding site [chemical binding]; other site 653045008891 active site 653045008892 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045008893 Helix-turn-helix domains; Region: HTH; cl00088 653045008894 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045008895 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045008896 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 653045008897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045008898 motif II; other site 653045008899 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 653045008900 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 653045008901 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 653045008902 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 653045008903 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 653045008904 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 653045008905 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045008906 Helix-turn-helix domains; Region: HTH; cl00088 653045008907 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045008908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045008909 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045008910 DNA binding residues [nucleotide binding] 653045008911 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 653045008912 Domain of unknown function (DUF305); Region: DUF305; cl15795 653045008913 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045008914 NB-ARC domain; Region: NB-ARC; pfam00931 653045008915 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045008916 TPR motif; other site 653045008917 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045008918 binding surface 653045008919 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045008920 binding surface 653045008921 TPR motif; other site 653045008922 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045008923 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045008924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045008925 RNA polymerase factor sigma-70; Validated; Region: PRK09047 653045008926 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045008927 Helix-turn-helix domains; Region: HTH; cl00088 653045008928 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045008929 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045008930 dimerization interface [polypeptide binding]; other site 653045008931 ligand binding site [chemical binding]; other site 653045008932 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045008933 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045008934 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 653045008935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008936 dimer interface [polypeptide binding]; other site 653045008937 conserved gate region; other site 653045008938 putative PBP binding loops; other site 653045008939 ABC-ATPase subunit interface; other site 653045008940 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045008941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045008942 dimer interface [polypeptide binding]; other site 653045008943 conserved gate region; other site 653045008944 putative PBP binding loops; other site 653045008945 ABC-ATPase subunit interface; other site 653045008946 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045008947 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 653045008948 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045008949 AMP-binding enzyme; Region: AMP-binding; cl15778 653045008950 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 653045008951 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 653045008952 putative acyl-acceptor binding pocket; other site 653045008953 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045008954 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 653045008955 active site 653045008956 catalytic residues [active] 653045008957 metal binding site [ion binding]; metal-binding site 653045008958 ChaB; Region: ChaB; cl01887 653045008959 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 653045008960 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14965 653045008961 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045008962 Helix-turn-helix domains; Region: HTH; cl00088 653045008963 ubiquinone biosynthesis O-methyltransferase; Region: UbiG; TIGR01983 653045008964 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045008965 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045008966 nudix motif; other site 653045008967 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045008968 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045008969 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045008970 GAF domain; Region: GAF_2; pfam13185 653045008971 GAF domain; Region: GAF; cl15785 653045008972 GAF domain; Region: GAF; cl15785 653045008973 GAF domain; Region: GAF_2; pfam13185 653045008974 Histidine kinase; Region: HisKA_3; pfam07730 653045008975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045008976 hypothetical protein; Provisional; Region: PRK07877 653045008977 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 653045008978 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045008979 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045008980 active site 653045008981 phosphorylation site [posttranslational modification] 653045008982 intermolecular recognition site; other site 653045008983 dimerization interface [polypeptide binding]; other site 653045008984 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045008985 DNA binding residues [nucleotide binding] 653045008986 dimerization interface [polypeptide binding]; other site 653045008987 FOG: CBS domain [General function prediction only]; Region: COG0517 653045008988 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586 653045008989 nicotinate phosphoribosyltransferase; Provisional; Region: PRK12484 653045008990 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 653045008991 active site 653045008992 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 653045008993 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045008994 catalytic Zn binding site [ion binding]; other site 653045008995 structural Zn binding site [ion binding]; other site 653045008996 NAD(P) binding site [chemical binding]; other site 653045008997 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 653045008998 Ligand Binding Site [chemical binding]; other site 653045008999 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 653045009000 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 653045009001 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 653045009002 FOG: CBS domain [General function prediction only]; Region: COG0517 653045009003 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 653045009004 FOG: CBS domain [General function prediction only]; Region: COG0517 653045009005 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 653045009006 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 653045009007 FAD binding domain; Region: FAD_binding_4; pfam01565 653045009008 D-arabinono-1,4-lactone oxidase; Region: ALO; cl04370 653045009009 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 653045009010 amphipathic channel; other site 653045009011 Asn-Pro-Ala signature motifs; other site 653045009012 glycerol kinase; Provisional; Region: glpK; PRK00047 653045009013 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 653045009014 N- and C-terminal domain interface [polypeptide binding]; other site 653045009015 putative active site [active] 653045009016 putative MgATP binding site [chemical binding]; other site 653045009017 catalytic site [active] 653045009018 metal binding site [ion binding]; metal-binding site 653045009019 putative homotetramer interface [polypeptide binding]; other site 653045009020 putative glycerol binding site [chemical binding]; other site 653045009021 homodimer interface [polypeptide binding]; other site 653045009022 Pseudomonas putida aldehyde-dismutating formaldehyde dehydrogenase (PFDH); Region: PFDH_like; cd08282 653045009023 formaldehyde dehydrogenase, glutathione-independent; Region: fdhA_non_GSH; TIGR02819 653045009024 NAD binding site [chemical binding]; other site 653045009025 catalytic Zn binding site [ion binding]; other site 653045009026 structural Zn binding site [ion binding]; other site 653045009027 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 653045009028 putative hydrophobic ligand binding site [chemical binding]; other site 653045009029 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045009030 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 653045009031 Gas vesicle protein G; Region: GvpG; pfam05120 653045009032 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 653045009033 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045009034 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 653045009035 Gas vesicle protein K; Region: GvpK; pfam05121 653045009036 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045009037 dimerization interface [polypeptide binding]; other site 653045009038 putative DNA binding site [nucleotide binding]; other site 653045009039 putative Zn2+ binding site [ion binding]; other site 653045009040 Predicted acyl esterases [General function prediction only]; Region: COG2936 653045009041 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045009042 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045009043 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045009044 substrate binding pocket [chemical binding]; other site 653045009045 membrane-bound complex binding site; other site 653045009046 hinge residues; other site 653045009047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045009048 active site 653045009049 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 653045009050 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 653045009051 Walker A/P-loop; other site 653045009052 ATP binding site [chemical binding]; other site 653045009053 Q-loop/lid; other site 653045009054 ABC transporter signature motif; other site 653045009055 Walker B; other site 653045009056 D-loop; other site 653045009057 H-loop/switch region; other site 653045009058 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045009059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045009060 dimer interface [polypeptide binding]; other site 653045009061 conserved gate region; other site 653045009062 putative PBP binding loops; other site 653045009063 ABC-ATPase subunit interface; other site 653045009064 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045009065 Coenzyme A binding pocket [chemical binding]; other site 653045009066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045009067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045009068 Helix-turn-helix domains; Region: HTH; cl00088 653045009069 PA14 domain; Region: PA14; cl08459 653045009070 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045009071 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045009072 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045009073 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045009074 classical (c) SDRs; Region: SDR_c; cd05233 653045009075 NAD(P) binding site [chemical binding]; other site 653045009076 active site 653045009077 Lamin Tail Domain; Region: LTD; pfam00932 653045009078 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 653045009079 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 653045009080 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 653045009081 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 653045009082 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 653045009083 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 653045009084 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045009085 DNA-binding site [nucleotide binding]; DNA binding site 653045009086 FCD domain; Region: FCD; cl11656 653045009087 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045009088 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045009089 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045009090 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 653045009091 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 653045009092 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 653045009093 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 653045009094 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 653045009095 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 653045009096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045009097 ATP binding site [chemical binding]; other site 653045009098 putative Mg++ binding site [ion binding]; other site 653045009099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045009100 nucleotide binding region [chemical binding]; other site 653045009101 ATP-binding site [chemical binding]; other site 653045009102 RQC domain; Region: RQC; cl09632 653045009103 HRDC domain; Region: HRDC; cl02578 653045009104 Streptomyces extracellular neutral proteinase (M7) family; Region: Peptidase_M7; pfam02031 653045009105 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045009106 Helix-turn-helix domains; Region: HTH; cl00088 653045009107 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045009108 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 653045009109 manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845 653045009110 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 653045009111 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009112 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045009113 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 653045009114 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 653045009115 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045009116 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 653045009117 putative NAD(P) binding site [chemical binding]; other site 653045009118 catalytic Zn binding site [ion binding]; other site 653045009119 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045009120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045009121 dimer interface [polypeptide binding]; other site 653045009122 conserved gate region; other site 653045009123 putative PBP binding loops; other site 653045009124 ABC-ATPase subunit interface; other site 653045009125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045009126 dimer interface [polypeptide binding]; other site 653045009127 conserved gate region; other site 653045009128 putative PBP binding loops; other site 653045009129 ABC-ATPase subunit interface; other site 653045009130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045009131 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045009132 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045009133 Helix-turn-helix domains; Region: HTH; cl00088 653045009134 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045009135 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 653045009136 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 653045009137 NAD binding site [chemical binding]; other site 653045009138 sugar binding site [chemical binding]; other site 653045009139 divalent metal binding site [ion binding]; other site 653045009140 tetramer (dimer of dimers) interface [polypeptide binding]; other site 653045009141 dimer interface [polypeptide binding]; other site 653045009142 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045009143 Helix-turn-helix domains; Region: HTH; cl00088 653045009144 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045009145 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045009146 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 653045009147 substrate binding site [chemical binding]; other site 653045009148 ATP binding site [chemical binding]; other site 653045009149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045009150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045009151 2-aminoethylphosphonate transport system permease PhnU; Provisional; Region: PRK15050 653045009152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045009153 dimer interface [polypeptide binding]; other site 653045009154 conserved gate region; other site 653045009155 putative PBP binding loops; other site 653045009156 ABC-ATPase subunit interface; other site 653045009157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045009158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045009159 dimer interface [polypeptide binding]; other site 653045009160 conserved gate region; other site 653045009161 putative PBP binding loops; other site 653045009162 ABC-ATPase subunit interface; other site 653045009163 Protein of unknown function DUF72; Region: DUF72; cl00777 653045009164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 653045009165 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 653045009166 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 653045009167 putative peptidoglycan binding site; other site 653045009168 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045009169 NB-ARC domain; Region: NB-ARC; pfam00931 653045009170 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045009171 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045009172 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045009173 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045009174 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045009175 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045009176 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045009177 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045009178 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 653045009179 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 653045009180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045009181 Walker A motif; other site 653045009182 ATP binding site [chemical binding]; other site 653045009183 Helix-turn-helix domains; Region: HTH; cl00088 653045009184 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009185 FAD binding domain; Region: FAD_binding_3; pfam01494 653045009186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009187 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045009188 YceI-like domain; Region: YceI; cl01001 653045009189 Protein of unknown function (DUF3761); Region: DUF3761; pfam12587 653045009190 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 653045009191 catalytic residues [active] 653045009192 dimer interface [polypeptide binding]; other site 653045009193 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 653045009194 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 653045009195 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 653045009196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045009197 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045009198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045009199 active site 653045009200 phosphorylation site [posttranslational modification] 653045009201 intermolecular recognition site; other site 653045009202 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 653045009203 dimerization interface [polypeptide binding]; other site 653045009204 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045009205 DNA binding residues [nucleotide binding] 653045009206 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 653045009207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045009208 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045009209 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045009210 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 653045009211 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045009212 Helix-turn-helix domains; Region: HTH; cl00088 653045009213 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 653045009214 putative dimerization interface [polypeptide binding]; other site 653045009215 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 653045009216 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 653045009217 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 653045009218 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 653045009219 putative NAD(P) binding site [chemical binding]; other site 653045009220 catalytic Zn binding site [ion binding]; other site 653045009221 structural Zn binding site [ion binding]; other site 653045009222 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 653045009223 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; cl15460 653045009224 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009225 NAD(P) binding site [chemical binding]; other site 653045009226 active site 653045009227 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045009228 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 653045009229 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 653045009230 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 653045009231 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 653045009232 siderophore binding site; other site 653045009233 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 653045009234 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 653045009235 Helix-turn-helix domains; Region: HTH; cl00088 653045009236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045009237 putative substrate translocation pore; other site 653045009238 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 653045009239 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 653045009240 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 653045009241 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 653045009242 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 653045009243 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 653045009244 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045009245 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 653045009246 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045009247 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045009248 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 653045009249 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 653045009250 pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301 653045009251 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045009252 FeS/SAM binding site; other site 653045009253 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 653045009254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009255 NAD(P) binding site [chemical binding]; other site 653045009256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009257 active site 653045009258 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 653045009259 putative ADP-binding pocket [chemical binding]; other site 653045009260 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045009261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045009262 active site 653045009263 phosphorylation site [posttranslational modification] 653045009264 intermolecular recognition site; other site 653045009265 dimerization interface [polypeptide binding]; other site 653045009266 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045009267 DNA binding site [nucleotide binding] 653045009268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045009269 dimer interface [polypeptide binding]; other site 653045009270 phosphorylation site [posttranslational modification] 653045009271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045009272 ATP binding site [chemical binding]; other site 653045009273 Mg2+ binding site [ion binding]; other site 653045009274 G-X-G motif; other site 653045009275 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045009276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045009277 S-adenosylmethionine binding site [chemical binding]; other site 653045009278 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045009279 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 653045009280 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045009281 non-specific DNA binding site [nucleotide binding]; other site 653045009282 salt bridge; other site 653045009283 sequence-specific DNA binding site [nucleotide binding]; other site 653045009284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045009285 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 653045009286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045009287 putative substrate translocation pore; other site 653045009288 Helix-turn-helix domains; Region: HTH; cl00088 653045009289 Magnesium transporter NIPA; Region: Mg_trans_NIPA; pfam05653 653045009290 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 653045009291 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 653045009292 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045009293 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045009294 methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642 653045009295 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677 653045009296 heterodimer interface [polypeptide binding]; other site 653045009297 substrate interaction site [chemical binding]; other site 653045009298 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 653045009299 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 653045009300 active site 653045009301 substrate binding site [chemical binding]; other site 653045009302 coenzyme B12 binding site [chemical binding]; other site 653045009303 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 653045009304 B12 binding site [chemical binding]; other site 653045009305 cobalt ligand [ion binding]; other site 653045009306 membrane ATPase/protein kinase; Provisional; Region: PRK09435 653045009307 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 653045009308 Walker A; other site 653045009309 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 653045009310 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 653045009311 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 653045009312 putative trimer interface [polypeptide binding]; other site 653045009313 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 653045009314 trimer interface [polypeptide binding]; other site 653045009315 active site 653045009316 substrate binding site [chemical binding]; other site 653045009317 putative CoA binding site [chemical binding]; other site 653045009318 CoA binding site [chemical binding]; other site 653045009319 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045009320 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 653045009321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045009322 S-adenosylmethionine binding site [chemical binding]; other site 653045009323 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045009324 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 653045009325 CbiD; Region: CbiD; cl00828 653045009326 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 653045009327 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045009328 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 653045009329 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 653045009330 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590 653045009331 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 653045009332 Precorrin-8X methylmutase; Region: CbiC; pfam02570 653045009333 precorrin-3B synthase; Region: CobG; TIGR02435 653045009334 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 653045009335 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 653045009336 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 653045009337 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 653045009338 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 653045009339 Cation efflux family; Region: Cation_efflux; cl00316 653045009340 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 653045009341 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 653045009342 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 653045009343 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 653045009344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045009345 motif II; other site 653045009346 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 653045009347 Lipase maturation factor; Region: LMF1; pfam06762 653045009348 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 653045009349 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 653045009350 dimer interface [polypeptide binding]; other site 653045009351 active site 653045009352 CoA binding pocket [chemical binding]; other site 653045009353 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 653045009354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009355 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045009356 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 653045009357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009358 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045009359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045009360 Predicted ATPase [General function prediction only]; Region: COG3899 653045009361 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 653045009362 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045009363 DNA binding residues [nucleotide binding] 653045009364 dimerization interface [polypeptide binding]; other site 653045009365 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 653045009366 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 653045009367 substrate binding site; other site 653045009368 tetramer interface; other site 653045009369 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 653045009370 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 653045009371 NAD binding site [chemical binding]; other site 653045009372 substrate binding site [chemical binding]; other site 653045009373 homodimer interface [polypeptide binding]; other site 653045009374 active site 653045009375 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045009376 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009377 active site 653045009378 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045009379 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009380 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009381 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009382 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009383 active site 653045009384 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009385 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009386 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009387 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009388 putative NADP binding site [chemical binding]; other site 653045009389 active site 653045009390 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009391 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009392 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045009393 active site 653045009394 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045009395 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009396 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045009397 NADP binding site [chemical binding]; other site 653045009398 active site 653045009399 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009400 Erythronolide synthase docking; Region: Docking; pfam08990 653045009401 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009402 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045009403 active site 653045009404 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045009405 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009406 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009407 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045009408 NADP binding site [chemical binding]; other site 653045009409 active site 653045009410 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009411 Erythronolide synthase docking; Region: Docking; pfam08990 653045009412 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009413 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045009414 active site 653045009415 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045009416 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009417 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045009418 NADP binding site [chemical binding]; other site 653045009419 active site 653045009420 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009421 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009422 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045009423 active site 653045009424 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045009425 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009426 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045009427 NADP binding site [chemical binding]; other site 653045009428 active site 653045009429 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009430 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009431 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009432 active site 653045009433 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009434 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009435 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009436 putative NADP binding site [chemical binding]; other site 653045009437 active site 653045009438 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009439 Erythronolide synthase docking; Region: Docking; pfam08990 653045009440 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009441 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009442 active site 653045009443 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009444 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009445 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009446 putative NADP binding site [chemical binding]; other site 653045009447 active site 653045009448 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009449 Thioesterase; Region: PKS_TE; smart00824 653045009450 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 653045009451 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 653045009452 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045009453 homodimer interface [polypeptide binding]; other site 653045009454 active site 653045009455 TDP-binding site; other site 653045009456 acceptor substrate-binding pocket; other site 653045009457 Cupin domain; Region: Cupin_2; cl09118 653045009458 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045009459 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 653045009460 Walker A/P-loop; other site 653045009461 ATP binding site [chemical binding]; other site 653045009462 Q-loop/lid; other site 653045009463 ABC transporter signature motif; other site 653045009464 Walker B; other site 653045009465 D-loop; other site 653045009466 H-loop/switch region; other site 653045009467 Histidine kinase; Region: HisKA_3; pfam07730 653045009468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045009469 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045009470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045009471 active site 653045009472 phosphorylation site [posttranslational modification] 653045009473 intermolecular recognition site; other site 653045009474 dimerization interface [polypeptide binding]; other site 653045009475 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045009476 DNA binding residues [nucleotide binding] 653045009477 dimerization interface [polypeptide binding]; other site 653045009478 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 653045009479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009480 NAD(P) binding site [chemical binding]; other site 653045009481 active site 653045009482 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045009483 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045009484 active site 653045009485 catalytic tetrad [active] 653045009486 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 653045009487 NDP-hexose 2,3-dehydratase; Region: Hexose_dehydrat; pfam03559 653045009488 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 653045009489 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045009490 NAD(P) binding site [chemical binding]; other site 653045009491 Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506 653045009492 heme binding pocket [chemical binding]; other site 653045009493 Animal heme peroxidases and related proteins; Region: An_peroxidase_like; cl14561 653045009494 heme binding site [chemical binding]; other site 653045009495 substrate binding site [chemical binding]; other site 653045009496 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 653045009497 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 653045009498 putative DNA binding site [nucleotide binding]; other site 653045009499 catalytic residue [active] 653045009500 putative H2TH interface [polypeptide binding]; other site 653045009501 putative catalytic residues [active] 653045009502 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 653045009503 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 653045009504 FAD binding domain; Region: FAD_binding_3; pfam01494 653045009505 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009506 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 653045009507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009508 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045009509 transketolase; Reviewed; Region: PRK05899 653045009510 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 653045009511 TPP-binding site [chemical binding]; other site 653045009512 dimer interface [polypeptide binding]; other site 653045009513 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 653045009514 PYR/PP interface [polypeptide binding]; other site 653045009515 dimer interface [polypeptide binding]; other site 653045009516 TPP binding site [chemical binding]; other site 653045009517 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 653045009518 UDP-glucose 4 epimerase (G4E), subgroup 3, extended (e) SDRs; Region: UDP_G4E_3_SDR_e; cd05240 653045009519 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045009520 putative NAD(P) binding site [chemical binding]; other site 653045009521 active site 653045009522 putative substrate binding site [chemical binding]; other site 653045009523 Catalytic domain of Streptomyces antibioticus phosphatidylinositol-specific phospholipase C1-like proteins; Region: PI-PLCc_SaPLC1_like; cd08589 653045009524 putative active site [active] 653045009525 catalytic site [active] 653045009526 putative metal binding site [ion binding]; other site 653045009527 Dodecin; Region: Dodecin; cl01328 653045009528 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 653045009529 Ligand Binding Site [chemical binding]; other site 653045009530 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 653045009531 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045009532 active site 653045009533 metal binding site [ion binding]; metal-binding site 653045009534 Protein of unknown function (DUF575); Region: DUF575; pfam04746 653045009535 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045009536 Protein of unknown function (DUF4239); Region: DUF4239; pfam14023 653045009537 enoyl-CoA hydratase; Provisional; Region: PRK08252 653045009538 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045009539 substrate binding site [chemical binding]; other site 653045009540 oxyanion hole (OAH) forming residues; other site 653045009541 trimer interface [polypeptide binding]; other site 653045009542 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 653045009543 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045009544 active site 653045009545 PaaX-like protein; Region: PaaX; pfam07848 653045009546 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 653045009547 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045009548 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045009549 DNA binding site [nucleotide binding] 653045009550 domain linker motif; other site 653045009551 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 653045009552 putative dimerization interface [polypeptide binding]; other site 653045009553 putative ligand binding site [chemical binding]; other site 653045009554 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045009555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045009556 active site 653045009557 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045009558 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045009559 active site 653045009560 short chain dehydrogenase; Provisional; Region: PRK07831 653045009561 classical (c) SDRs; Region: SDR_c; cd05233 653045009562 NAD(P) binding site [chemical binding]; other site 653045009563 active site 653045009564 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045009565 Helix-turn-helix domains; Region: HTH; cl00088 653045009566 acetyl-CoA acetyltransferase; Provisional; Region: PRK07801 653045009567 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045009568 dimer interface [polypeptide binding]; other site 653045009569 active site 653045009570 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 653045009571 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 653045009572 Ubiquitin-like proteins; Region: UBQ; cl00155 653045009573 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 653045009574 Protein of unknown function DUF82; Region: DUF82; pfam01927 653045009575 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 653045009576 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 653045009577 dimer interface [polypeptide binding]; other site 653045009578 N-terminal domain interface [polypeptide binding]; other site 653045009579 substrate binding pocket (H-site) [chemical binding]; other site 653045009580 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045009581 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045009582 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 653045009583 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 653045009584 DNA binding site [nucleotide binding] 653045009585 catalytic residue [active] 653045009586 H2TH interface [polypeptide binding]; other site 653045009587 putative catalytic residues [active] 653045009588 turnover-facilitating residue; other site 653045009589 intercalation triad [nucleotide binding]; other site 653045009590 8OG recognition residue [nucleotide binding]; other site 653045009591 putative reading head residues; other site 653045009592 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 653045009593 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 653045009594 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045009595 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 653045009596 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 653045009597 D-pathway; other site 653045009598 Putative ubiquinol binding site [chemical binding]; other site 653045009599 Low-spin heme (heme b) binding site [chemical binding]; other site 653045009600 Putative water exit pathway; other site 653045009601 Binuclear center (heme o3/CuB) [ion binding]; other site 653045009602 K-pathway; other site 653045009603 Putative proton exit pathway; other site 653045009604 Transglycosylase; Region: Transgly; cl07896 653045009605 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 653045009606 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045009607 sensory histidine kinase CreC; Provisional; Region: PRK11100 653045009608 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045009609 dimer interface [polypeptide binding]; other site 653045009610 phosphorylation site [posttranslational modification] 653045009611 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045009612 ATP binding site [chemical binding]; other site 653045009613 Mg2+ binding site [ion binding]; other site 653045009614 G-X-G motif; other site 653045009615 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045009616 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045009617 active site 653045009618 phosphorylation site [posttranslational modification] 653045009619 intermolecular recognition site; other site 653045009620 dimerization interface [polypeptide binding]; other site 653045009621 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045009622 DNA binding site [nucleotide binding] 653045009623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045009624 putative active site [active] 653045009625 heme pocket [chemical binding]; other site 653045009626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045009627 DNA binding residues [nucleotide binding] 653045009628 dimerization interface [polypeptide binding]; other site 653045009629 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 653045009630 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 653045009631 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 653045009632 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045009633 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 653045009634 RNA polymerase factor sigma-70; Validated; Region: PRK08241 653045009635 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045009636 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045009637 DNA binding residues [nucleotide binding] 653045009638 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045009639 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 653045009640 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045009641 active site 653045009642 intersubunit interface [polypeptide binding]; other site 653045009643 zinc binding site [ion binding]; other site 653045009644 Na+ binding site [ion binding]; other site 653045009645 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 653045009646 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 653045009647 dimer interface [polypeptide binding]; other site 653045009648 active site 653045009649 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 653045009650 dimer interface [polypeptide binding]; other site 653045009651 active site 653045009652 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045009653 Helix-turn-helix domains; Region: HTH; cl00088 653045009654 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045009655 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 653045009656 trimer interface [polypeptide binding]; other site 653045009657 active site 653045009658 dimer interface [polypeptide binding]; other site 653045009659 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 653045009660 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 653045009661 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045009662 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045009663 sugar binding site [chemical binding]; other site 653045009664 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045009665 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045009666 DNA binding site [nucleotide binding] 653045009667 domain linker motif; other site 653045009668 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 653045009669 putative dimerization interface [polypeptide binding]; other site 653045009670 putative ligand binding site [chemical binding]; other site 653045009671 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045009672 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045009673 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045009674 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045009675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045009676 dimer interface [polypeptide binding]; other site 653045009677 conserved gate region; other site 653045009678 putative PBP binding loops; other site 653045009679 ABC-ATPase subunit interface; other site 653045009680 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045009681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045009682 dimer interface [polypeptide binding]; other site 653045009683 conserved gate region; other site 653045009684 putative PBP binding loops; other site 653045009685 ABC-ATPase subunit interface; other site 653045009686 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 653045009687 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045009688 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045009689 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 653045009690 active site 653045009691 catalytic residues [active] 653045009692 Domain of unknown function (DUF718); Region: DUF718; cl01281 653045009693 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045009694 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045009695 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 653045009696 Fe-S cluster binding site [ion binding]; other site 653045009697 DNA binding site [nucleotide binding] 653045009698 active site 653045009699 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 653045009700 hypothetical protein; Provisional; Region: PRK08609 653045009701 active site 653045009702 primer binding site [nucleotide binding]; other site 653045009703 NTP binding site [chemical binding]; other site 653045009704 metal binding triad [ion binding]; metal-binding site 653045009705 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045009706 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045009707 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 653045009708 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045009709 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045009710 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 653045009711 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045009712 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 653045009713 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 653045009714 putative active site [active] 653045009715 glucose-1-dehydrogenase; Provisional; Region: PRK08936 653045009716 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 653045009717 NAD binding site [chemical binding]; other site 653045009718 homodimer interface [polypeptide binding]; other site 653045009719 active site 653045009720 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045009721 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045009722 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045009723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045009724 DNA binding residues [nucleotide binding] 653045009725 Membrane transport protein; Region: Mem_trans; cl09117 653045009726 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 653045009727 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045009728 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045009729 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 653045009730 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045009731 DNA-binding site [nucleotide binding]; DNA binding site 653045009732 FCD domain; Region: FCD; cl11656 653045009733 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045009734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045009735 DNA-binding site [nucleotide binding]; DNA binding site 653045009736 FCD domain; Region: FCD; cl11656 653045009737 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045009738 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 653045009739 NAD(P) binding site [chemical binding]; other site 653045009740 catalytic residues [active] 653045009741 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 653045009742 Amino acid synthesis; Region: AA_synth; pfam06684 653045009743 Amino acid synthesis; Region: AA_synth; pfam06684 653045009744 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045009745 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 653045009746 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045009747 Flavin Reductases; Region: FlaRed; cl00801 653045009748 Sodium:solute symporter family; Region: SSF; cl00456 653045009749 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045009750 non-specific DNA binding site [nucleotide binding]; other site 653045009751 salt bridge; other site 653045009752 sequence-specific DNA binding site [nucleotide binding]; other site 653045009753 Cupin domain; Region: Cupin_2; cl09118 653045009754 Helix-turn-helix domains; Region: HTH; cl00088 653045009755 Protein of unknown function (DUF2000); Region: DUF2000; cl02074 653045009756 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 653045009757 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009758 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 653045009759 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 653045009760 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045009761 Protein of unknown function (DUF1275); Region: DUF1275; cl01453 653045009762 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 653045009763 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045009764 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 653045009765 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 653045009766 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 653045009767 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 653045009768 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 653045009769 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045009770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045009771 putative substrate translocation pore; other site 653045009772 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045009773 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 653045009774 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045009775 Uncharacterized conserved protein [Function unknown]; Region: COG2128 653045009776 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 653045009777 substrate-cofactor binding pocket; other site 653045009778 AMP-binding enzyme; Region: AMP-binding; cl15778 653045009779 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 653045009780 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 653045009781 Glutamine amidotransferase class-I; Region: GATase; pfam00117 653045009782 glutamine binding [chemical binding]; other site 653045009783 catalytic triad [active] 653045009784 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 653045009785 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 653045009786 chorismate binding enzyme; Region: Chorismate_bind; cl10555 653045009787 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045009788 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 653045009789 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045009790 inhibitor-cofactor binding pocket; inhibition site 653045009791 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045009792 catalytic residue [active] 653045009793 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 653045009794 Amidinotransferase; Region: Amidinotransf; cl12043 653045009795 Helix-turn-helix domains; Region: HTH; cl00088 653045009796 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 653045009797 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045009798 active site 653045009799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009800 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009801 active site 653045009802 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009803 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009805 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045009806 Enoylreductase; Region: PKS_ER; smart00829 653045009807 NAD(P) binding site [chemical binding]; other site 653045009808 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 653045009809 putative NADP binding site [chemical binding]; other site 653045009810 active site 653045009811 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009812 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045009813 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009814 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045009815 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045009816 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045009817 GAF domain; Region: GAF_2; pfam13185 653045009818 GAF domain; Region: GAF; cl15785 653045009819 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045009820 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045009821 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045009822 Cupin domain; Region: Cupin_2; cl09118 653045009823 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045009824 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045009825 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 653045009826 classical (c) SDRs; Region: SDR_c; cd05233 653045009827 NAD(P) binding site [chemical binding]; other site 653045009828 active site 653045009829 Helix-turn-helix domains; Region: HTH; cl00088 653045009830 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 653045009831 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 653045009832 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045009833 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045009834 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045009835 Helix-turn-helix domains; Region: HTH; cl00088 653045009836 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 653045009837 substrate binding site [chemical binding]; other site 653045009838 ATP binding site [chemical binding]; other site 653045009839 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 653045009840 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 653045009841 Protein of unknown function (DUF419); Region: DUF419; cl15265 653045009842 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045009843 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045009844 TPR motif; other site 653045009845 Tetratricopeptide repeat; Region: TPR_16; pfam13432 653045009846 binding surface 653045009847 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045009848 binding surface 653045009849 TPR motif; other site 653045009850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 653045009851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045009852 Coenzyme A binding pocket [chemical binding]; other site 653045009853 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045009854 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045009855 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045009856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045009857 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 653045009858 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 653045009859 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 653045009860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045009861 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045009862 DNA binding residues [nucleotide binding] 653045009863 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045009864 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045009865 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 653045009866 Clp amino terminal domain; Region: Clp_N; pfam02861 653045009867 Clp amino terminal domain; Region: Clp_N; pfam02861 653045009868 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045009869 Walker A motif; other site 653045009870 ATP binding site [chemical binding]; other site 653045009871 Walker B motif; other site 653045009872 arginine finger; other site 653045009873 UvrB/uvrC motif; Region: UVR; pfam02151 653045009874 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045009875 Walker A motif; other site 653045009876 ATP binding site [chemical binding]; other site 653045009877 Walker B motif; other site 653045009878 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 653045009879 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 653045009880 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 653045009881 putative active site [active] 653045009882 putative metal binding site [ion binding]; other site 653045009883 Leucine carboxyl methyltransferase; Region: LCM; cl01306 653045009884 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 653045009885 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045009886 Helix-turn-helix domains; Region: HTH; cl00088 653045009887 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045009888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045009889 S-adenosylmethionine binding site [chemical binding]; other site 653045009890 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045009891 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009892 active site 653045009893 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045009894 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009895 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009896 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009897 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009898 active site 653045009899 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009900 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009901 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009902 Erythronolide synthase docking; Region: Docking; pfam08990 653045009903 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009904 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009905 active site 653045009906 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009907 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009908 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009909 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045009910 Enoylreductase; Region: PKS_ER; smart00829 653045009911 NAD(P) binding site [chemical binding]; other site 653045009912 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009913 putative NADP binding site [chemical binding]; other site 653045009914 active site 653045009915 acyl-CoA synthetase; Validated; Region: PRK06060 653045009916 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009917 Erythronolide synthase docking; Region: Docking; pfam08990 653045009918 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009919 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009920 active site 653045009921 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009922 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009923 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009924 putative NADP binding site [chemical binding]; other site 653045009925 active site 653045009926 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009927 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009928 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009929 active site 653045009930 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009931 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009933 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045009934 Enoylreductase; Region: PKS_ER; smart00829 653045009935 NAD(P) binding site [chemical binding]; other site 653045009936 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009937 putative NADP binding site [chemical binding]; other site 653045009938 active site 653045009939 acyl-CoA synthetase; Validated; Region: PRK06060 653045009940 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009941 Erythronolide synthase docking; Region: Docking; pfam08990 653045009942 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009943 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009944 active site 653045009945 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009946 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009947 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009948 putative NADP binding site [chemical binding]; other site 653045009949 active site 653045009950 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009951 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009952 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009953 active site 653045009954 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009955 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009957 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045009958 Enoylreductase; Region: PKS_ER; smart00829 653045009959 NAD(P) binding site [chemical binding]; other site 653045009960 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009961 putative NADP binding site [chemical binding]; other site 653045009962 active site 653045009963 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009964 acyl-CoA synthetase; Validated; Region: PRK06060 653045009965 Erythronolide synthase docking; Region: Docking; pfam08990 653045009966 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009967 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009968 active site 653045009969 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009970 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009971 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009972 putative NADP binding site [chemical binding]; other site 653045009973 active site 653045009974 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009975 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045009976 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009977 active site 653045009978 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009979 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045009980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045009981 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045009982 Enoylreductase; Region: PKS_ER; smart00829 653045009983 NAD(P) binding site [chemical binding]; other site 653045009984 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045009985 putative NADP binding site [chemical binding]; other site 653045009986 active site 653045009987 acyl-CoA synthetase; Validated; Region: PRK06060 653045009988 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009989 Erythronolide synthase docking; Region: Docking; pfam08990 653045009990 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045009991 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045009992 active site 653045009993 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045009994 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045009995 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045009996 NADP binding site [chemical binding]; other site 653045009997 active site 653045009998 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045009999 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045010000 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045010001 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045010002 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010003 Erythronolide synthase docking; Region: Docking; pfam08990 653045010004 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010005 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010006 active site 653045010007 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010008 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010009 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010010 NADP binding site [chemical binding]; other site 653045010011 active site 653045010012 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 653045010013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010014 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045010015 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045010016 Erythronolide synthase docking; Region: Docking; pfam08990 653045010017 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010018 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010019 active site 653045010020 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010021 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010022 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010023 putative NADP binding site [chemical binding]; other site 653045010024 active site 653045010025 acyl-CoA synthetase; Validated; Region: PRK06060 653045010026 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010027 Erythronolide synthase docking; Region: Docking; pfam08990 653045010028 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010029 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010030 active site 653045010031 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010032 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010033 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010034 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045010035 Enoylreductase; Region: PKS_ER; smart00829 653045010036 NAD(P) binding site [chemical binding]; other site 653045010037 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010038 putative NADP binding site [chemical binding]; other site 653045010039 active site 653045010040 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010041 Erythronolide synthase docking; Region: Docking; pfam08990 653045010042 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010043 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010044 active site 653045010045 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010046 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010047 NADP binding site [chemical binding]; other site 653045010048 active site 653045010049 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010050 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010051 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010052 active site 653045010053 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010054 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010055 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010056 NADP binding site [chemical binding]; other site 653045010057 active site 653045010058 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010059 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010060 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010061 active site 653045010062 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010063 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010064 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010065 NADP binding site [chemical binding]; other site 653045010066 active site 653045010067 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010068 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 653045010069 metal binding site [ion binding]; metal-binding site 653045010070 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 653045010071 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 653045010072 AMP-binding enzyme; Region: AMP-binding; cl15778 653045010073 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045010074 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 653045010075 ArsC family; Region: ArsC; pfam03960 653045010076 catalytic residues [active] 653045010077 Domain of unknown function (DUF305); Region: DUF305; cl15795 653045010078 Peptidase family M48; Region: Peptidase_M48; cl12018 653045010079 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 653045010080 Helix-turn-helix domains; Region: HTH; cl00088 653045010081 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045010082 putative metal binding site [ion binding]; other site 653045010083 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 653045010084 metal ion-dependent adhesion site (MIDAS); other site 653045010085 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045010086 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 653045010087 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045010088 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045010089 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045010090 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 653045010091 Walker A/P-loop; other site 653045010092 ATP binding site [chemical binding]; other site 653045010093 Q-loop/lid; other site 653045010094 ABC transporter signature motif; other site 653045010095 Walker B; other site 653045010096 D-loop; other site 653045010097 H-loop/switch region; other site 653045010098 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010099 hypothetical protein; Validated; Region: PRK05868 653045010100 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 653045010101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045010102 active site 653045010103 phosphorylation site [posttranslational modification] 653045010104 dimerization interface [polypeptide binding]; other site 653045010105 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 653045010106 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 653045010107 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 653045010108 DXD motif; other site 653045010109 OpgC protein; Region: OpgC_C; cl00792 653045010110 CH-type (Chalaropsis-type) lysozymes represent one of four functionally-defined classes of peptidoglycan hydrolases (also referred to as endo-N-acetylmuramidases) that cleave bacterial cell wall peptidoglycans. CH-type lysozymes exhibit both lysozyme; Region: GH25_CH-type; cd06412 653045010111 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 653045010112 active site 653045010113 Helix-turn-helix domains; Region: HTH; cl00088 653045010114 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 653045010115 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045010116 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045010117 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 653045010118 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 653045010119 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 653045010120 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045010121 catalytic loop [active] 653045010122 iron binding site [ion binding]; other site 653045010123 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045010124 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 653045010125 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 653045010126 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 653045010127 XdhC Rossmann domain; Region: XdhC_C; pfam13478 653045010128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045010129 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045010130 putative substrate translocation pore; other site 653045010131 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010132 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 653045010133 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 653045010134 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045010135 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045010136 tetracycline repressor protein TetR; Provisional; Region: PRK13756 653045010137 Helix-turn-helix domains; Region: HTH; cl00088 653045010138 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045010139 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045010140 Helix-turn-helix domains; Region: HTH; cl00088 653045010141 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045010142 putative dimerization interface [polypeptide binding]; other site 653045010143 Cysteine dioxygenase type I; Region: CDO_I; cl15835 653045010144 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045010145 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 653045010146 putative dimer interface [polypeptide binding]; other site 653045010147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045010148 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 653045010149 putative dimerization interface [polypeptide binding]; other site 653045010150 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 653045010151 Predicted peptidase [General function prediction only]; Region: COG4099 653045010152 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045010153 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045010154 Helix-turn-helix domains; Region: HTH; cl00088 653045010155 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045010156 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 653045010157 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045010158 Helix-turn-helix domains; Region: HTH; cl00088 653045010159 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 653045010160 TPP-binding site [chemical binding]; other site 653045010161 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 653045010162 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 653045010163 PYR/PP interface [polypeptide binding]; other site 653045010164 dimer interface [polypeptide binding]; other site 653045010165 TPP binding site [chemical binding]; other site 653045010166 DoxX; Region: DoxX; cl00976 653045010167 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045010168 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 653045010169 active site 653045010170 metal binding site [ion binding]; metal-binding site 653045010171 homotetramer interface [polypeptide binding]; other site 653045010172 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045010173 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045010174 DNA-binding site [nucleotide binding]; DNA binding site 653045010175 FCD domain; Region: FCD; cl11656 653045010176 proline aminopeptidase P II; Provisional; Region: PRK10879 653045010177 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 653045010178 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 653045010179 active site 653045010180 Peptidase family M9 N-terminal; Region: Peptidase_M9_N; pfam08453 653045010181 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 653045010182 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 653045010183 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 653045010184 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045010185 active site 653045010186 metal binding site [ion binding]; metal-binding site 653045010187 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 653045010188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045010189 Probable transposase; Region: OrfB_IS605; pfam01385 653045010190 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045010191 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045010192 putative substrate translocation pore; other site 653045010193 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 653045010194 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 653045010195 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 653045010196 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 653045010197 putative active site pocket [active] 653045010198 putative metal binding site [ion binding]; other site 653045010199 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045010200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045010201 DNA-binding site [nucleotide binding]; DNA binding site 653045010202 FCD domain; Region: FCD; cl11656 653045010203 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045010204 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 653045010205 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 653045010206 DNA binding residues [nucleotide binding] 653045010207 putative dimer interface [polypeptide binding]; other site 653045010208 Sulfatase; Region: Sulfatase; cl10460 653045010209 Integral membrane protein TerC family; Region: TerC; cl10468 653045010210 Polysulphide reductase, NrfD; Region: NrfD; cl01295 653045010211 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 653045010212 4Fe-4S binding domain; Region: Fer4; cl02805 653045010213 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 653045010214 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045010215 molybdopterin cofactor binding site; other site 653045010216 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045010217 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045010218 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 653045010219 molybdopterin cofactor binding site; other site 653045010220 Protein of unknown function (DUF429); Region: DUF429; cl12046 653045010221 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 653045010222 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 653045010223 putative peptidoglycan binding site; other site 653045010224 Peptidase family M23; Region: Peptidase_M23; pfam01551 653045010225 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 653045010226 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 653045010227 MOSC domain; Region: MOSC; pfam03473 653045010228 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045010229 hydrophobic ligand binding site; other site 653045010230 Helix-turn-helix domains; Region: HTH; cl00088 653045010231 Helix-turn-helix domains; Region: HTH; cl00088 653045010232 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045010233 Helix-turn-helix domains; Region: HTH; cl00088 653045010234 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 653045010235 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 653045010236 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 653045010237 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 653045010238 metal binding site [ion binding]; metal-binding site 653045010239 dimer interface [polypeptide binding]; other site 653045010240 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045010241 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045010242 non-specific DNA binding site [nucleotide binding]; other site 653045010243 salt bridge; other site 653045010244 sequence-specific DNA binding site [nucleotide binding]; other site 653045010245 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 653045010246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045010247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045010248 homodimer interface [polypeptide binding]; other site 653045010249 catalytic residue [active] 653045010250 Predicted ATPase [General function prediction only]; Region: COG3903 653045010251 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 653045010252 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045010253 DNA binding residues [nucleotide binding] 653045010254 dimerization interface [polypeptide binding]; other site 653045010255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045010256 TOMM system kinase/cyclase multidomain protein; Region: TOMM_kin_cyc; TIGR03903 653045010257 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045010258 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045010259 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045010260 DNA binding residues [nucleotide binding] 653045010261 dimerization interface [polypeptide binding]; other site 653045010262 Predicted ATPase [General function prediction only]; Region: COG3899 653045010263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045010264 Helix-turn-helix domains; Region: HTH; cl00088 653045010265 Predicted ATPase [General function prediction only]; Region: COG3899 653045010266 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045010267 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045010268 DNA binding residues [nucleotide binding] 653045010269 dimerization interface [polypeptide binding]; other site 653045010270 PAS fold; Region: PAS_4; pfam08448 653045010271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045010272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045010273 DNA binding residues [nucleotide binding] 653045010274 dimerization interface [polypeptide binding]; other site 653045010275 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 653045010276 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 653045010277 Helix-turn-helix domains; Region: HTH; cl00088 653045010278 4-aminobutyrate aminotransferase; Provisional; Region: PRK08117 653045010279 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045010280 inhibitor-cofactor binding pocket; inhibition site 653045010281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045010282 catalytic residue [active] 653045010283 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045010284 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 653045010285 tetramerization interface [polypeptide binding]; other site 653045010286 NAD(P) binding site [chemical binding]; other site 653045010287 catalytic residues [active] 653045010288 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045010289 putative metal binding site [ion binding]; other site 653045010290 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 653045010291 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 653045010292 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 653045010293 hypothetical protein; Provisional; Region: PRK06185 653045010294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010296 amino acid permease (GABA permease); Region: 2A0304; TIGR00907 653045010297 Spore germination protein; Region: Spore_permease; cl15802 653045010298 Spore germination protein; Region: Spore_permease; cl15802 653045010299 glycerol kinase; Region: glycerol_kin; TIGR01311 653045010300 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 653045010301 N- and C-terminal domain interface [polypeptide binding]; other site 653045010302 active site 653045010303 MgATP binding site [chemical binding]; other site 653045010304 catalytic site [active] 653045010305 metal binding site [ion binding]; metal-binding site 653045010306 carbohydrate binding site [chemical binding]; other site 653045010307 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010308 Predicted dehydrogenase [General function prediction only]; Region: COG0579 653045010309 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 653045010310 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 653045010311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 653045010312 RNA binding surface [nucleotide binding]; other site 653045010313 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 653045010314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010315 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045010316 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 653045010317 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045010318 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 653045010319 GAF domain; Region: GAF; cl15785 653045010320 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045010321 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045010322 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045010323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045010324 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045010325 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 653045010326 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010327 Nitronate monooxygenase; Region: NMO; pfam03060 653045010328 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 653045010329 FMN binding site [chemical binding]; other site 653045010330 substrate binding site [chemical binding]; other site 653045010331 putative catalytic residue [active] 653045010332 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045010333 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045010334 enoyl-CoA hydratase; Provisional; Region: PRK06495 653045010335 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045010336 substrate binding site [chemical binding]; other site 653045010337 oxyanion hole (OAH) forming residues; other site 653045010338 trimer interface [polypeptide binding]; other site 653045010339 classical (c) SDRs; Region: SDR_c; cd05233 653045010340 NAD(P) binding site [chemical binding]; other site 653045010341 active site 653045010342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010343 NAD(P) binding site [chemical binding]; other site 653045010344 active site 653045010345 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 653045010346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010347 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 653045010348 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 653045010349 putative peptidoglycan binding site; other site 653045010350 Peptidase family M23; Region: Peptidase_M23; pfam01551 653045010351 probable methyltransferase; Region: TIGR03438 653045010352 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 653045010353 TIGR03442 family protein; Region: TIGR03442 653045010354 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 653045010355 putative active site [active] 653045010356 putative dimer interface [polypeptide binding]; other site 653045010357 TIGR03440 family protein; Region: unchr_TIGR03440 653045010358 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 653045010359 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 653045010360 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 653045010361 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045010362 NAD(P) binding site [chemical binding]; other site 653045010363 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045010364 active site 653045010365 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045010366 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045010367 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045010368 active site 653045010369 choline dehydrogenase; Validated; Region: PRK02106 653045010370 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 653045010371 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045010372 ligand binding site [chemical binding]; other site 653045010373 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045010374 ligand binding site [chemical binding]; other site 653045010375 flexible hinge region; other site 653045010376 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 653045010377 putative active site [active] 653045010378 catalytic site [active] 653045010379 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 653045010380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045010381 Coenzyme A binding pocket [chemical binding]; other site 653045010382 Helix-turn-helix domains; Region: HTH; cl00088 653045010383 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045010384 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045010385 D-xylulose kinase; Region: XylB; TIGR01312 653045010386 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 653045010387 active site 653045010388 MgATP binding site [chemical binding]; other site 653045010389 N- and C-terminal domain interface [polypeptide binding]; other site 653045010390 catalytic site [active] 653045010391 metal binding site [ion binding]; metal-binding site 653045010392 carbohydrate binding site [chemical binding]; other site 653045010393 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 653045010394 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045010395 Pectinesterase; Region: Pectinesterase; cl01911 653045010396 SWIM zinc finger; Region: SWIM; cl15408 653045010397 SNF2 Helicase protein; Region: DUF3670; pfam12419 653045010398 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 653045010399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045010400 ATP binding site [chemical binding]; other site 653045010401 putative Mg++ binding site [ion binding]; other site 653045010402 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045010403 nucleotide binding region [chemical binding]; other site 653045010404 ATP-binding site [chemical binding]; other site 653045010405 Helix-turn-helix domains; Region: HTH; cl00088 653045010406 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 653045010407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045010408 S-adenosylmethionine binding site [chemical binding]; other site 653045010409 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045010410 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 653045010411 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045010412 NAD binding site [chemical binding]; other site 653045010413 catalytic Zn binding site [ion binding]; other site 653045010414 structural Zn binding site [ion binding]; other site 653045010415 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045010416 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045010417 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 653045010418 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 653045010419 active site 653045010420 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 653045010421 catalytic triad [active] 653045010422 dimer interface [polypeptide binding]; other site 653045010423 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045010424 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045010425 ATP binding site [chemical binding]; other site 653045010426 putative Mg++ binding site [ion binding]; other site 653045010427 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045010428 nucleotide binding region [chemical binding]; other site 653045010429 ATP-binding site [chemical binding]; other site 653045010430 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 653045010431 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 653045010432 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045010433 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045010434 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045010435 Walker A/P-loop; other site 653045010436 ATP binding site [chemical binding]; other site 653045010437 Q-loop/lid; other site 653045010438 ABC transporter signature motif; other site 653045010439 Walker B; other site 653045010440 D-loop; other site 653045010441 H-loop/switch region; other site 653045010442 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045010443 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045010444 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045010445 Q-loop/lid; other site 653045010446 ABC transporter signature motif; other site 653045010447 Walker B; other site 653045010448 D-loop; other site 653045010449 H-loop/switch region; other site 653045010450 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 653045010451 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045010452 Helix-turn-helix domains; Region: HTH; cl00088 653045010453 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045010454 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045010455 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045010456 Walker A/P-loop; other site 653045010457 ATP binding site [chemical binding]; other site 653045010458 Q-loop/lid; other site 653045010459 ABC transporter signature motif; other site 653045010460 Walker B; other site 653045010461 D-loop; other site 653045010462 H-loop/switch region; other site 653045010463 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 653045010464 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 653045010465 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 653045010466 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 653045010467 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 653045010468 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 653045010469 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 653045010470 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 653045010471 putative peptidoglycan binding site; other site 653045010472 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 653045010473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: VgrG; COG3501 653045010474 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 653045010475 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 653045010476 Baseplate J-like protein; Region: Baseplate_J; cl01294 653045010477 Baseplate J-like protein; Region: Baseplate_J; cl01294 653045010478 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; cl01817 653045010479 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045010480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045010481 Walker A motif; other site 653045010482 ATP binding site [chemical binding]; other site 653045010483 Walker B motif; other site 653045010484 arginine finger; other site 653045010485 Helix-turn-helix domains; Region: HTH; cl00088 653045010486 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045010487 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045010488 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 653045010489 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045010490 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010491 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010492 active site 653045010493 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010494 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010495 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010496 putative NADP binding site [chemical binding]; other site 653045010497 active site 653045010498 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010499 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010500 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010501 active site 653045010502 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010503 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010504 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010505 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045010506 Enoylreductase; Region: PKS_ER; smart00829 653045010507 NAD(P) binding site [chemical binding]; other site 653045010508 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010509 putative NADP binding site [chemical binding]; other site 653045010510 active site 653045010511 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010512 Erythronolide synthase docking; Region: Docking; pfam08990 653045010513 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010514 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010515 active site 653045010516 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010517 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010518 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010519 NADP binding site [chemical binding]; other site 653045010520 active site 653045010521 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010522 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010523 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010524 active site 653045010525 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010526 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010527 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010528 putative NADP binding site [chemical binding]; other site 653045010529 active site 653045010530 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010531 Erythronolide synthase docking; Region: Docking; pfam08990 653045010532 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010533 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010534 active site 653045010535 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010536 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010537 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010538 putative NADP binding site [chemical binding]; other site 653045010539 active site 653045010540 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010541 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010542 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010543 active site 653045010544 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010545 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010546 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010547 NADP binding site [chemical binding]; other site 653045010548 active site 653045010549 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010550 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010551 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010552 active site 653045010553 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010554 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010555 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010556 NADP binding site [chemical binding]; other site 653045010557 active site 653045010558 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010559 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010560 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010561 active site 653045010562 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010563 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010564 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010565 NADP binding site [chemical binding]; other site 653045010566 active site 653045010567 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010568 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010569 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010570 active site 653045010571 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010572 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010573 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010574 NADP binding site [chemical binding]; other site 653045010575 active site 653045010576 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010577 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010578 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010579 active site 653045010580 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010581 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010582 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010583 NADP binding site [chemical binding]; other site 653045010584 active site 653045010585 acyl-CoA synthetase; Validated; Region: PRK06060 653045010586 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010587 Erythronolide synthase docking; Region: Docking; pfam08990 653045010588 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010589 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010590 active site 653045010591 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010592 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010593 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010594 NADP binding site [chemical binding]; other site 653045010595 active site 653045010596 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010597 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010598 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010599 active site 653045010600 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010601 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010602 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010603 NADP binding site [chemical binding]; other site 653045010604 active site 653045010605 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010606 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010607 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010608 active site 653045010609 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010610 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010611 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010612 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010613 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010614 active site 653045010615 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010616 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010617 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010618 NADP binding site [chemical binding]; other site 653045010619 active site 653045010620 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010621 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010622 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010623 active site 653045010624 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010625 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010626 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010627 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045010628 Enoylreductase; Region: PKS_ER; smart00829 653045010629 NAD(P) binding site [chemical binding]; other site 653045010630 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010631 putative NADP binding site [chemical binding]; other site 653045010632 active site 653045010633 acyl-CoA synthetase; Validated; Region: PRK06060 653045010634 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010635 Erythronolide synthase docking; Region: Docking; pfam08990 653045010636 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010637 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010638 active site 653045010639 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010640 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010641 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010642 NADP binding site [chemical binding]; other site 653045010643 active site 653045010644 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010645 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010646 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010647 active site 653045010648 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010649 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010650 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010651 NADP binding site [chemical binding]; other site 653045010652 active site 653045010653 acyl-CoA synthetase; Validated; Region: PRK06060 653045010654 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010655 Erythronolide synthase docking; Region: Docking; pfam08990 653045010656 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010657 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010658 active site 653045010659 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010660 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010661 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010662 NADP binding site [chemical binding]; other site 653045010663 active site 653045010664 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010665 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010666 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045010667 active site 653045010668 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010669 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010670 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010671 NADP binding site [chemical binding]; other site 653045010672 active site 653045010673 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010674 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010675 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010676 active site 653045010677 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010678 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010679 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010680 putative NADP binding site [chemical binding]; other site 653045010681 active site 653045010682 acyl-CoA synthetase; Validated; Region: PRK06060 653045010683 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010684 Erythronolide synthase docking; Region: Docking; pfam08990 653045010685 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010686 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010687 active site 653045010688 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010689 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010690 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010691 putative NADP binding site [chemical binding]; other site 653045010692 active site 653045010693 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045010694 NADP binding site [chemical binding]; other site 653045010695 active site 653045010696 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010697 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010698 Thioesterase; Region: PKS_TE; smart00824 653045010699 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010700 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045010701 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045010702 active site 653045010703 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010704 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045010705 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010706 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045010707 Enoylreductase; Region: PKS_ER; smart00829 653045010708 NAD(P) binding site [chemical binding]; other site 653045010709 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045010710 putative NADP binding site [chemical binding]; other site 653045010711 active site 653045010712 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045010713 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045010714 AMP-binding enzyme; Region: AMP-binding; cl15778 653045010715 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045010716 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045010717 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045010718 Helix-turn-helix domains; Region: HTH; cl00088 653045010719 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045010720 Helix-turn-helix domains; Region: HTH; cl00088 653045010721 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 653045010722 homotrimer interaction site [polypeptide binding]; other site 653045010723 putative active site [active] 653045010724 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 653045010725 Protein of unknown function (DUF3616); Region: DUF3616; pfam12275 653045010726 Sulphur transport; Region: Sulf_transp; cl01018 653045010727 putative inner membrane protein; Provisional; Region: PRK11099 653045010728 Sulphur transport; Region: Sulf_transp; cl01018 653045010729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045010730 sequence-specific DNA binding site [nucleotide binding]; other site 653045010731 salt bridge; other site 653045010732 Cupin domain; Region: Cupin_2; cl09118 653045010733 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045010734 S-adenosylmethionine binding site [chemical binding]; other site 653045010735 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045010736 DinB superfamily; Region: DinB_2; pfam12867 653045010737 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045010738 Helix-turn-helix domains; Region: HTH; cl00088 653045010739 DNA-binding site [nucleotide binding]; DNA binding site 653045010740 FCD domain; Region: FCD; cl11656 653045010741 Predicted amidohydrolase [General function prediction only]; Region: COG0388 653045010742 Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576 653045010743 putative active site [active] 653045010744 catalytic triad [active] 653045010745 putative dimer interface [polypeptide binding]; other site 653045010746 Amino acid permease; Region: AA_permease; pfam00324 653045010747 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045010748 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 653045010749 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 653045010750 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 653045010751 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 653045010752 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 653045010753 Ferritin-like domain; Region: Ferritin; pfam00210 653045010754 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 653045010755 dinuclear metal binding motif [ion binding]; other site 653045010756 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 653045010757 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045010758 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045010759 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 653045010760 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 653045010761 xanthine dehydrogenase E subunit; Region: pucE; TIGR03198 653045010762 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045010763 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045010764 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045010765 Helix-turn-helix domains; Region: HTH; cl00088 653045010766 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045010767 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010768 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045010769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010770 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045010771 short chain dehydrogenase; Provisional; Region: PRK06198 653045010772 classical (c) SDRs; Region: SDR_c; cd05233 653045010773 NAD(P) binding site [chemical binding]; other site 653045010774 active site 653045010775 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 653045010776 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045010777 DNA binding site [nucleotide binding] 653045010778 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 653045010779 putative ligand binding site [chemical binding]; other site 653045010780 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 653045010781 conserved cys residue [active] 653045010782 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 653045010783 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 653045010784 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045010785 Walker A/P-loop; other site 653045010786 ATP binding site [chemical binding]; other site 653045010787 Q-loop/lid; other site 653045010788 ABC transporter signature motif; other site 653045010789 Walker B; other site 653045010790 D-loop; other site 653045010791 H-loop/switch region; other site 653045010792 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045010793 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045010794 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045010795 Walker A/P-loop; other site 653045010796 ATP binding site [chemical binding]; other site 653045010797 Q-loop/lid; other site 653045010798 ABC transporter signature motif; other site 653045010799 Walker B; other site 653045010800 D-loop; other site 653045010801 H-loop/switch region; other site 653045010802 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045010803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045010804 dimer interface [polypeptide binding]; other site 653045010805 conserved gate region; other site 653045010806 putative PBP binding loops; other site 653045010807 ABC-ATPase subunit interface; other site 653045010808 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045010809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045010810 dimer interface [polypeptide binding]; other site 653045010811 conserved gate region; other site 653045010812 putative PBP binding loops; other site 653045010813 ABC-ATPase subunit interface; other site 653045010814 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045010815 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 653045010816 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010817 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045010818 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010819 NAD(P) binding site [chemical binding]; other site 653045010820 active site 653045010821 Helix-turn-helix domains; Region: HTH; cl00088 653045010822 D-cysteine desulfhydrase; Validated; Region: PRK03910 653045010823 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 653045010824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045010825 catalytic residue [active] 653045010826 Predicted transcriptional regulator [Transcription]; Region: COG2378 653045010827 Helix-turn-helix domains; Region: HTH; cl00088 653045010828 WYL domain; Region: WYL; cl14852 653045010829 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045010830 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045010831 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 653045010832 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045010833 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045010834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045010835 DNA-binding site [nucleotide binding]; DNA binding site 653045010836 UTRA domain; Region: UTRA; cl01230 653045010837 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 653045010838 Sodium:solute symporter family; Region: SSF; cl00456 653045010839 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045010840 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 653045010841 substrate binding site [chemical binding]; other site 653045010842 ATP binding site [chemical binding]; other site 653045010843 Helix-turn-helix domains; Region: HTH; cl00088 653045010844 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045010845 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010846 NAD(P) binding site [chemical binding]; other site 653045010847 active site 653045010848 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 653045010849 DJ-1 family protein; Region: not_thiJ; TIGR01383 653045010850 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 653045010851 conserved cys residue [active] 653045010852 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 653045010853 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 653045010854 active site 653045010855 dimer interface [polypeptide binding]; other site 653045010856 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 653045010857 Ligand Binding Site [chemical binding]; other site 653045010858 Molecular Tunnel; other site 653045010859 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289 653045010860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010861 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 653045010862 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045010863 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 653045010864 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045010865 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010866 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045010867 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 653045010868 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 653045010869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010870 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045010871 dimer interface [polypeptide binding]; other site 653045010872 conserved gate region; other site 653045010873 putative PBP binding loops; other site 653045010874 ABC-ATPase subunit interface; other site 653045010875 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 653045010876 active site 653045010877 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 653045010878 dimer interface [polypeptide binding]; other site 653045010879 non-prolyl cis peptide bond; other site 653045010880 insertion regions; other site 653045010881 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045010882 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045010883 substrate binding pocket [chemical binding]; other site 653045010884 membrane-bound complex binding site; other site 653045010885 hinge residues; other site 653045010886 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045010887 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045010888 putative NAD(P) binding site [chemical binding]; other site 653045010889 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 653045010890 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045010891 Walker A/P-loop; other site 653045010892 ATP binding site [chemical binding]; other site 653045010893 Q-loop/lid; other site 653045010894 ABC transporter signature motif; other site 653045010895 Walker B; other site 653045010896 D-loop; other site 653045010897 H-loop/switch region; other site 653045010898 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045010899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045010900 dimer interface [polypeptide binding]; other site 653045010901 conserved gate region; other site 653045010902 putative PBP binding loops; other site 653045010903 ABC-ATPase subunit interface; other site 653045010904 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045010905 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 653045010906 Walker A/P-loop; other site 653045010907 ATP binding site [chemical binding]; other site 653045010908 Q-loop/lid; other site 653045010909 ABC transporter signature motif; other site 653045010910 Walker B; other site 653045010911 D-loop; other site 653045010912 H-loop/switch region; other site 653045010913 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045010914 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045010915 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045010916 dimer interface [polypeptide binding]; other site 653045010917 conserved gate region; other site 653045010918 putative PBP binding loops; other site 653045010919 ABC-ATPase subunit interface; other site 653045010920 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045010921 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045010922 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045010923 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045010924 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045010925 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045010926 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045010927 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045010928 Helix-turn-helix domains; Region: HTH; cl00088 653045010929 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045010930 [FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105 653045010931 4Fe-4S binding domain; Region: Fer4; cl02805 653045010932 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 653045010933 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045010934 active site 2 [active] 653045010935 active site 1 [active] 653045010936 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045010937 Helix-turn-helix domains; Region: HTH; cl00088 653045010938 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045010939 acetoin dehydrogenase E2 subunit dihydrolipoyllysine-residue acetyltransferase; Provisional; Region: PRK14875 653045010940 Subunit B of the Class III Extradiol dioxygenase, Protocatechuate 4,5-dioxygenase, and simlar enzymes; Region: PCA_45_Doxase_B_like; cd07359 653045010941 active site 653045010942 Fe(II) binding site [ion binding]; other site 653045010943 dimer interface [polypeptide binding]; other site 653045010944 tetramer interface [polypeptide binding]; other site 653045010945 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 653045010946 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 653045010947 metal binding site [ion binding]; metal-binding site 653045010948 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 653045010949 iron-sulfur cluster [ion binding]; other site 653045010950 [2Fe-2S] cluster binding site [ion binding]; other site 653045010951 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045010952 hydrophobic ligand binding site; other site 653045010953 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045010954 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045010955 NAD(P) binding site [chemical binding]; other site 653045010956 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045010957 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045010958 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045010959 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 653045010960 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045010961 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 653045010962 AMP-binding enzyme; Region: AMP-binding; cl15778 653045010963 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045010964 LysE type translocator; Region: LysE; cl00565 653045010965 O-Antigen ligase; Region: Wzy_C; cl04850 653045010966 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045010967 Helix-turn-helix domains; Region: HTH; cl00088 653045010968 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045010969 Helix-turn-helix domains; Region: HTH; cl00088 653045010970 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 653045010971 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 653045010972 Amidohydrolase; Region: Amidohydro_4; pfam13147 653045010973 active site 653045010974 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 653045010975 Domain of unknown function (DUF427); Region: DUF427; cl00998 653045010976 Domain of unknown function (DUF427); Region: DUF427; cl00998 653045010977 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 653045010978 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 653045010979 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045010980 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 653045010981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045010982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045010983 DNA binding site [nucleotide binding] 653045010984 domain linker motif; other site 653045010985 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 653045010986 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 653045010987 active site 653045010988 oxyanion hole [active] 653045010989 catalytic triad [active] 653045010990 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 653045010991 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 653045010992 Walker A/P-loop; other site 653045010993 ATP binding site [chemical binding]; other site 653045010994 Q-loop/lid; other site 653045010995 ABC transporter signature motif; other site 653045010996 Walker B; other site 653045010997 D-loop; other site 653045010998 H-loop/switch region; other site 653045010999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045011000 dimer interface [polypeptide binding]; other site 653045011001 conserved gate region; other site 653045011002 putative PBP binding loops; other site 653045011003 ABC-ATPase subunit interface; other site 653045011004 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045011005 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045011006 substrate binding pocket [chemical binding]; other site 653045011007 membrane-bound complex binding site; other site 653045011008 hinge residues; other site 653045011009 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 653045011010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 653045011011 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 653045011012 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045011013 DNA binding residues [nucleotide binding] 653045011014 drug binding residues [chemical binding]; other site 653045011015 dimer interface [polypeptide binding]; other site 653045011016 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 653045011017 Protein phosphatase 2C; Region: PP2C; pfam00481 653045011018 active site 653045011019 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 653045011020 active site 653045011021 Glycosyl hydrolase family 43, includes mostly 1,4-beta-xylanases; Region: GH43_bXyl; cd09004 653045011022 putative substrate binding site [chemical binding]; other site 653045011023 active site 653045011024 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 653045011025 active site 653045011026 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 653045011027 active site 653045011028 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 653045011029 active site 653045011030 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 653045011031 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 653045011032 putative sugar binding sites [chemical binding]; other site 653045011033 Q-X-W motif; other site 653045011034 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 653045011035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 653045011036 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102 653045011037 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045011038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045011039 active site 653045011040 catalytic tetrad [active] 653045011041 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 653045011042 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045011043 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 653045011044 Family description; Region: VCBS; pfam13517 653045011045 Family description; Region: VCBS; pfam13517 653045011046 FG-GAP repeat; Region: FG-GAP; cl15299 653045011047 FG-GAP repeat; Region: FG-GAP; cl15299 653045011048 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045011049 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045011050 active site 653045011051 catalytic tetrad [active] 653045011052 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 653045011053 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 653045011054 putative active site pocket [active] 653045011055 putative metal binding site [ion binding]; other site 653045011056 Predicted amidohydrolase [General function prediction only]; Region: COG0388 653045011057 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 653045011058 active site 653045011059 catalytic triad [active] 653045011060 dimer interface [polypeptide binding]; other site 653045011061 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 653045011062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011063 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045011064 putative substrate translocation pore; other site 653045011065 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045011066 Helix-turn-helix domains; Region: HTH; cl00088 653045011067 Uncharacterized conserved protein [Function unknown]; Region: COG3391 653045011068 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 653045011069 Oxysterol-binding protein; Region: Oxysterol_BP; pfam01237 653045011070 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045011071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011072 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 653045011073 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045011074 motif II; other site 653045011075 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 653045011076 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 653045011077 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 653045011078 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 653045011079 hypothetical protein; Provisional; Region: PRK07945 653045011080 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 653045011081 Glycoside hydrolase 97; Region: Glyco_hydro_97; pfam10566 653045011082 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011083 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011084 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 653045011085 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 653045011086 Helix-turn-helix domains; Region: HTH; cl00088 653045011087 Isochorismatase family; Region: Isochorismatase; pfam00857 653045011088 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 653045011089 catalytic triad [active] 653045011090 conserved cis-peptide bond; other site 653045011091 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 653045011092 Helix-turn-helix domains; Region: HTH; cl00088 653045011093 Helix-turn-helix domains; Region: HTH; cl00088 653045011094 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 653045011095 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 653045011096 active site 653045011097 metal binding site [ion binding]; metal-binding site 653045011098 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 653045011099 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011100 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045011101 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 653045011102 NAD(P) binding site [chemical binding]; other site 653045011103 catalytic residues [active] 653045011104 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 653045011105 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 653045011106 active site pocket [active] 653045011107 Formaldehyde-activating enzyme (Fae); Region: Fae; cl00774 653045011108 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045011109 Helix-turn-helix domains; Region: HTH; cl00088 653045011110 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045011111 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045011112 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 653045011113 tetramerization interface [polypeptide binding]; other site 653045011114 NAD(P) binding site [chemical binding]; other site 653045011115 catalytic residues [active] 653045011116 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011117 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045011118 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011119 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 653045011120 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045011121 conserved cys residue [active] 653045011122 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045011123 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045011124 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045011125 Helix-turn-helix domains; Region: HTH; cl00088 653045011126 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045011127 Helix-turn-helix domains; Region: HTH; cl00088 653045011128 Arginase family; Region: Arginase; cl00306 653045011129 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 653045011130 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 653045011131 putative molybdopterin cofactor binding site [chemical binding]; other site 653045011132 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 653045011133 putative molybdopterin cofactor binding site; other site 653045011134 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 653045011135 putative hydrophobic ligand binding site [chemical binding]; other site 653045011136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011137 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 653045011138 putative substrate translocation pore; other site 653045011139 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011140 DoxX; Region: DoxX; cl00976 653045011141 Cupin domain; Region: Cupin_2; cl09118 653045011142 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 653045011143 Helix-turn-helix domains; Region: HTH; cl00088 653045011144 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045011145 dimerization interface [polypeptide binding]; other site 653045011146 substrate binding pocket [chemical binding]; other site 653045011147 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 653045011148 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045011149 catalytic site [active] 653045011150 Helix-turn-helix domains; Region: HTH; cl00088 653045011151 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045011152 alpha-galactosidase; Region: PLN02229 653045011153 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045011154 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 653045011155 Ca binding site [ion binding]; other site 653045011156 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 653045011157 active site 653045011158 catalytic triad [active] 653045011159 oxyanion hole [active] 653045011160 Helix-turn-helix domains; Region: HTH; cl00088 653045011161 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045011162 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 653045011163 Helix-turn-helix domains; Region: HTH; cl00088 653045011164 Integrase core domain; Region: rve; cl01316 653045011165 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045011166 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045011167 putative NAD(P) binding site [chemical binding]; other site 653045011168 Helix-turn-helix domains; Region: HTH; cl00088 653045011169 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 653045011170 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045011171 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045011172 active site 653045011173 metal binding site [ion binding]; metal-binding site 653045011174 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 653045011175 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045011176 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045011177 Helix-turn-helix domains; Region: HTH; cl00088 653045011178 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045011179 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011180 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045011181 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 653045011182 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045011183 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045011184 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045011185 enoyl-CoA hydratase; Provisional; Region: PRK08138 653045011186 substrate binding site [chemical binding]; other site 653045011187 oxyanion hole (OAH) forming residues; other site 653045011188 trimer interface [polypeptide binding]; other site 653045011189 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 653045011190 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 653045011191 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 653045011192 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045011193 catalytic loop [active] 653045011194 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045011195 iron binding site [ion binding]; other site 653045011196 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045011197 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 653045011198 putative hydrophobic ligand binding site [chemical binding]; other site 653045011199 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 653045011200 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045011201 Tannase and feruloyl esterase; Region: Tannase; pfam07519 653045011202 3HB-oligomer hydrolase (3HBOH); Region: 3HBOH; pfam10605 653045011203 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011204 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045011205 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045011206 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045011207 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 653045011208 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045011209 DNA binding site [nucleotide binding] 653045011210 domain linker motif; other site 653045011211 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045011212 ligand binding site [chemical binding]; other site 653045011213 dimerization interface [polypeptide binding]; other site 653045011214 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 653045011215 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 653045011216 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 653045011217 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 653045011218 active site 653045011219 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 653045011220 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045011221 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045011222 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883 653045011223 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045011224 nucleophilic elbow; other site 653045011225 catalytic triad; other site 653045011226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045011227 Helix-turn-helix domains; Region: HTH; cl00088 653045011228 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045011229 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 653045011230 putative NAD(P) binding site [chemical binding]; other site 653045011231 active site 653045011232 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045011233 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 653045011234 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045011235 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045011236 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045011237 Flavin Reductases; Region: FlaRed; cl00801 653045011238 putative FMN-dependent luciferase-like monooxygenase, KPN_01858 family; Region: LLM_KPN_01858; TIGR04027 653045011239 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045011240 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 653045011241 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045011242 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045011243 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045011244 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 653045011245 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045011246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045011247 dimer interface [polypeptide binding]; other site 653045011248 conserved gate region; other site 653045011249 putative PBP binding loops; other site 653045011250 ABC-ATPase subunit interface; other site 653045011251 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 653045011252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045011253 dimer interface [polypeptide binding]; other site 653045011254 conserved gate region; other site 653045011255 putative PBP binding loops; other site 653045011256 ABC-ATPase subunit interface; other site 653045011257 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045011258 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045011259 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045011260 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 653045011261 substrate binding site [chemical binding]; other site 653045011262 ATP binding site [chemical binding]; other site 653045011263 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045011264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045011265 DNA-binding site [nucleotide binding]; DNA binding site 653045011266 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045011267 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 653045011268 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 653045011269 NAD binding site [chemical binding]; other site 653045011270 sugar binding site [chemical binding]; other site 653045011271 divalent metal binding site [ion binding]; other site 653045011272 tetramer (dimer of dimers) interface [polypeptide binding]; other site 653045011273 dimer interface [polypeptide binding]; other site 653045011274 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 653045011275 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 653045011276 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 653045011277 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 653045011278 Helix-turn-helix domains; Region: HTH; cl00088 653045011279 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 653045011280 CoenzymeA binding site [chemical binding]; other site 653045011281 subunit interaction site [polypeptide binding]; other site 653045011282 PHB binding site; other site 653045011283 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045011284 NAD(P) binding site [chemical binding]; other site 653045011285 beta-D-glucuronidase; Provisional; Region: PRK10150 653045011286 Histidine kinase; Region: HisKA_3; pfam07730 653045011287 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045011288 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045011289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045011290 active site 653045011291 phosphorylation site [posttranslational modification] 653045011292 intermolecular recognition site; other site 653045011293 dimerization interface [polypeptide binding]; other site 653045011294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045011295 dimerization interface [polypeptide binding]; other site 653045011296 DNA binding residues [nucleotide binding] 653045011297 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 653045011298 putative active site [active] 653045011299 putative catalytic site [active] 653045011300 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 653045011301 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011302 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011303 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045011304 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045011305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011306 NAD(P) binding site [chemical binding]; other site 653045011307 active site 653045011308 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045011309 Helix-turn-helix domains; Region: HTH; cl00088 653045011310 Phenylacetic acid-responsive transcriptional repressor [Transcription]; Region: PaaX; COG3327 653045011311 PaaX-like protein; Region: PaaX; pfam07848 653045011312 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 653045011313 probable F420-dependent oxidoreductase, MSMEG_2516 family; Region: F420_MSMEG_2516; TIGR03621 653045011314 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045011315 Helix-turn-helix domains; Region: HTH; cl00088 653045011316 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045011317 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045011318 active site 653045011319 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 653045011320 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011321 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045011322 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045011323 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045011324 Helix-turn-helix domains; Region: HTH; cl00088 653045011325 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045011326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011327 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 653045011328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011330 putative substrate translocation pore; other site 653045011331 Helix-turn-helix domains; Region: HTH; cl00088 653045011332 ApbE family; Region: ApbE; cl00643 653045011333 FMN-binding domain; Region: FMN_bind; cl01081 653045011334 Helix-turn-helix domains; Region: HTH; cl00088 653045011335 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045011336 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045011337 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 653045011338 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 653045011339 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 653045011340 dimer interface [polypeptide binding]; other site 653045011341 active site 653045011342 non-prolyl cis peptide bond; other site 653045011343 insertion regions; other site 653045011344 crotonobetaine/carnitine-CoA ligase; Provisional; Region: PRK06155 653045011345 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011346 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045011347 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 653045011348 active site 653045011349 catalytic residues [active] 653045011350 metal binding site [ion binding]; metal-binding site 653045011351 tricarballylate dehydrogenase; Validated; Region: PRK08274 653045011352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011353 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045011354 Helix-turn-helix domains; Region: HTH; cl00088 653045011355 Flavin Reductases; Region: FlaRed; cl00801 653045011356 TIGR03084 family protein; Region: TIGR03084 653045011357 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045011358 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 653045011359 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045011360 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045011361 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045011362 Helix-turn-helix domains; Region: HTH; cl00088 653045011363 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045011364 dimerization interface [polypeptide binding]; other site 653045011365 substrate binding pocket [chemical binding]; other site 653045011366 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045011367 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045011368 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045011369 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519 653045011370 active site flap/lid [active] 653045011371 nucleophilic elbow; other site 653045011372 catalytic triad [active] 653045011373 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 653045011374 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 653045011375 active site 653045011376 substrate binding site [chemical binding]; other site 653045011377 ATP binding site [chemical binding]; other site 653045011378 Phosphotransferase enzyme family; Region: APH; pfam01636 653045011379 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045011380 Helix-turn-helix domains; Region: HTH; cl00088 653045011381 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 653045011382 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011383 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045011384 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 653045011385 NAD(P) binding site [chemical binding]; other site 653045011386 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 653045011387 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 653045011388 inhibitor site; inhibition site 653045011389 active site 653045011390 dimer interface [polypeptide binding]; other site 653045011391 catalytic residue [active] 653045011392 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045011393 Helix-turn-helix domains; Region: HTH; cl00088 653045011394 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045011395 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045011396 putative NAD(P) binding site [chemical binding]; other site 653045011397 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 653045011398 amphipathic channel; other site 653045011399 Asn-Pro-Ala signature motifs; other site 653045011400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045011401 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 653045011402 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045011403 Helix-turn-helix domains; Region: HTH; cl00088 653045011404 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045011405 Helix-turn-helix domains; Region: HTH; cl00088 653045011406 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Uncharacterized Proteins with similarity to Ornithine and Diaminopimelate Decarboxylases; Region: PLPDE_III_ODC_DapDC_like_1; cd06836 653045011407 diaminopimelate decarboxylase; Region: lysA; TIGR01048 653045011408 active site 653045011409 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045011410 dimer interface [polypeptide binding]; other site 653045011411 catalytic residues [active] 653045011412 substrate binding site [chemical binding]; other site 653045011413 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 653045011414 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 653045011415 active site 653045011416 putative substrate binding pocket [chemical binding]; other site 653045011417 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045011418 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045011419 anti sigma factor interaction site; other site 653045011420 regulatory phosphorylation site [posttranslational modification]; other site 653045011421 ANTAR domain; Region: ANTAR; cl04297 653045011422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011423 NAD(P) binding site [chemical binding]; other site 653045011424 active site 653045011425 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045011426 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045011427 active site 653045011428 catalytic tetrad [active] 653045011429 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 653045011430 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 653045011431 active site 653045011432 FMN binding site [chemical binding]; other site 653045011433 substrate binding site [chemical binding]; other site 653045011434 3Fe-4S cluster binding site [ion binding]; other site 653045011435 Restriction endonuclease; Region: Mrr_cat; cl00516 653045011436 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045011437 ATP binding site [chemical binding]; other site 653045011438 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 653045011439 Catalytic site [active] 653045011440 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045011441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045011442 Walker A/P-loop; other site 653045011443 ATP binding site [chemical binding]; other site 653045011444 Q-loop/lid; other site 653045011445 ABC transporter signature motif; other site 653045011446 Walker B; other site 653045011447 D-loop; other site 653045011448 H-loop/switch region; other site 653045011449 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 653045011450 catalytic residues [active] 653045011451 Helix-turn-helix domain; Region: HTH_18; pfam12833 653045011452 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045011453 TIGR03086 family protein; Region: TIGR03086 653045011454 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; cl01113 653045011455 agmatine deiminase; Region: agmatine_aguA; TIGR03380 653045011456 Helix-turn-helix domains; Region: HTH; cl00088 653045011457 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045011458 Helix-turn-helix domains; Region: HTH; cl00088 653045011459 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045011460 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045011461 active site 653045011462 metal binding site [ion binding]; metal-binding site 653045011463 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045011464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045011465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045011466 active site 653045011467 phosphorylation site [posttranslational modification] 653045011468 intermolecular recognition site; other site 653045011469 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045011470 DNA binding residues [nucleotide binding] 653045011471 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045011472 Histidine kinase; Region: HisKA_3; pfam07730 653045011473 Predicted transcriptional regulators [Transcription]; Region: COG1510 653045011474 choline dehydrogenase; Validated; Region: PRK02106 653045011475 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 653045011476 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045011477 NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078 653045011478 NAD(P) binding site [chemical binding]; other site 653045011479 catalytic residues [active] 653045011480 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 653045011481 amidohydrolase; Region: amidohydrolases; TIGR01891 653045011482 metal binding site [ion binding]; metal-binding site 653045011483 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 653045011484 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045011485 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 653045011486 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 653045011487 tetramer interface [polypeptide binding]; other site 653045011488 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045011489 catalytic residue [active] 653045011490 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045011491 Sulfatase; Region: Sulfatase; cl10460 653045011492 Uncharacterized conserved protein [Function unknown]; Region: COG1262 653045011493 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 653045011494 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 653045011495 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 653045011496 FAD binding pocket [chemical binding]; other site 653045011497 FAD binding motif [chemical binding]; other site 653045011498 phosphate binding motif [ion binding]; other site 653045011499 beta-alpha-beta structure motif; other site 653045011500 NAD binding pocket [chemical binding]; other site 653045011501 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045011502 catalytic loop [active] 653045011503 iron binding site [ion binding]; other site 653045011504 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 653045011505 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 653045011506 [2Fe-2S] cluster binding site [ion binding]; other site 653045011507 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 653045011508 putative alpha subunit interface [polypeptide binding]; other site 653045011509 putative active site [active] 653045011510 putative substrate binding site [chemical binding]; other site 653045011511 Fe binding site [ion binding]; other site 653045011512 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045011513 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045011514 Probable transposase; Region: OrfB_IS605; pfam01385 653045011515 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045011516 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045011517 Helix-turn-helix domains; Region: HTH; cl00088 653045011518 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045011519 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274 653045011520 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045011521 putative NAD(P) binding site [chemical binding]; other site 653045011522 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045011523 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 653045011524 metal binding site [ion binding]; metal-binding site 653045011525 substrate binding pocket [chemical binding]; other site 653045011526 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045011527 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045011528 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045011529 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045011530 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045011531 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 653045011532 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045011533 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 653045011534 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045011535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045011536 Helix-turn-helix domains; Region: HTH; cl00088 653045011537 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 653045011538 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 653045011539 DNA binding residues [nucleotide binding] 653045011540 dimer interface [polypeptide binding]; other site 653045011541 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 653045011542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011543 putative substrate translocation pore; other site 653045011544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045011545 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045011546 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 653045011547 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045011548 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 653045011549 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 653045011550 inhibitor binding site; inhibition site 653045011551 active site 653045011552 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 653045011553 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 653045011554 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 653045011555 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 653045011556 classical (c) SDRs; Region: SDR_c; cd05233 653045011557 NAD(P) binding site [chemical binding]; other site 653045011558 active site 653045011559 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045011560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011562 Helix-turn-helix domains; Region: HTH; cl00088 653045011563 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045011564 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 653045011565 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045011566 NAD binding site [chemical binding]; other site 653045011567 catalytic residues [active] 653045011568 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 653045011569 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 653045011570 NAD binding site [chemical binding]; other site 653045011571 catalytic Zn binding site [ion binding]; other site 653045011572 substrate binding site [chemical binding]; other site 653045011573 structural Zn binding site [ion binding]; other site 653045011574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011575 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045011576 putative substrate translocation pore; other site 653045011577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011578 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045011579 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045011580 DNA binding site [nucleotide binding] 653045011581 domain linker motif; other site 653045011582 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045011583 ligand binding site [chemical binding]; other site 653045011584 dimerization interface [polypeptide binding]; other site 653045011585 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 653045011586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045011587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045011588 dimer interface [polypeptide binding]; other site 653045011589 conserved gate region; other site 653045011590 putative PBP binding loops; other site 653045011591 ABC-ATPase subunit interface; other site 653045011592 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045011593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045011594 dimer interface [polypeptide binding]; other site 653045011595 conserved gate region; other site 653045011596 putative PBP binding loops; other site 653045011597 ABC-ATPase subunit interface; other site 653045011598 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 653045011599 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 653045011600 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045011601 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011603 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045011604 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045011605 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045011606 DNA-binding site [nucleotide binding]; DNA binding site 653045011607 UTRA domain; Region: UTRA; cl01230 653045011608 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045011609 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 653045011610 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 653045011611 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045011612 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 653045011613 NAD(P) binding site [chemical binding]; other site 653045011614 catalytic residues [active] 653045011615 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011616 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 653045011617 putative active site [active] 653045011618 putative NTP binding site [chemical binding]; other site 653045011619 putative nucleic acid binding site [nucleotide binding]; other site 653045011620 DDE superfamily endonuclease; Region: DDE_5; cl02413 653045011621 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045011622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045011623 DNA-binding site [nucleotide binding]; DNA binding site 653045011624 FCD domain; Region: FCD; cl11656 653045011625 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 653045011626 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045011627 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045011628 active site 653045011629 metal binding site [ion binding]; metal-binding site 653045011630 C-terminal domain of Burkholderia sp. NF100 MhqB and similar proteins; MhqB is a type I extradiol dioxygenase involved in the catabolism of methylhydroquinone, an intermediate in the degradation of fenitrothion; Region: MhqB_like_C; cd08360 653045011631 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045011632 putative active site [active] 653045011633 putative metal binding site [ion binding]; other site 653045011634 hypothetical protein; Provisional; Region: PRK06126 653045011635 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045011636 phosphate binding site [ion binding]; other site 653045011637 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045011638 3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843 653045011639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045011640 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 653045011641 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045011642 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 653045011643 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 653045011644 NAD binding site [chemical binding]; other site 653045011645 catalytic Zn binding site [ion binding]; other site 653045011646 substrate binding site [chemical binding]; other site 653045011647 structural Zn binding site [ion binding]; other site 653045011648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045011649 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045011650 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045011651 Fatty acid desaturase; Region: FA_desaturase; pfam00487 653045011652 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 653045011653 putative di-iron ligands [ion binding]; other site 653045011654 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045011655 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045011656 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 653045011657 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045011658 active site 653045011659 DNA binding site [nucleotide binding] 653045011660 Int/Topo IB signature motif; other site 653045011661 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 653045011662 Transposase domain (DUF772); Region: DUF772; pfam05598 653045011663 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011664 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045011665 MULE transposase domain; Region: MULE; pfam10551 653045011666 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045011667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045011668 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011669 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045011670 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011671 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 653045011672 CrcB-like protein; Region: CRCB; cl09114 653045011673 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 653045011674 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045011675 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 653045011676 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011677 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011678 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 653045011679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045011680 S-adenosylmethionine binding site [chemical binding]; other site 653045011681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011682 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045011683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011684 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045011685 argininosuccinate lyase; Provisional; Region: PRK02186 653045011686 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045011687 peptide synthase; Provisional; Region: PRK12467 653045011688 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011689 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011691 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045011692 putative substrate translocation pore; other site 653045011693 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 653045011694 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 653045011695 active site 653045011696 non-prolyl cis peptide bond; other site 653045011697 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 653045011698 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 653045011699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011700 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045011701 glycolate oxidase; Region: PLN02535 653045011702 phosphate binding site [ion binding]; other site 653045011703 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011704 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 653045011705 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045011706 glycerol kinase; Provisional; Region: glpK; PRK00047 653045011707 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 653045011708 N- and C-terminal domain interface [polypeptide binding]; other site 653045011709 active site 653045011710 MgATP binding site [chemical binding]; other site 653045011711 catalytic site [active] 653045011712 metal binding site [ion binding]; metal-binding site 653045011713 carbohydrate binding site [chemical binding]; other site 653045011714 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 653045011715 Helix-turn-helix domain; Region: HTH_18; pfam12833 653045011716 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045011717 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 653045011718 glycerol kinase; Provisional; Region: glpK; PRK00047 653045011719 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 653045011720 N- and C-terminal domain interface [polypeptide binding]; other site 653045011721 active site 653045011722 MgATP binding site [chemical binding]; other site 653045011723 catalytic site [active] 653045011724 metal binding site [ion binding]; metal-binding site 653045011725 carbohydrate binding site [chemical binding]; other site 653045011726 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 653045011727 putative catalytic residues [active] 653045011728 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 653045011729 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 653045011730 TPP-binding site; other site 653045011731 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 653045011732 PYR/PP interface [polypeptide binding]; other site 653045011733 dimer interface [polypeptide binding]; other site 653045011734 TPP binding site [chemical binding]; other site 653045011735 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 653045011736 Helix-turn-helix domains; Region: HTH; cl00088 653045011737 Biofilm formation and stress response factor; Region: BsmA; cl01794 653045011738 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045011739 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011740 putative substrate translocation pore; other site 653045011741 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011742 putative substrate translocation pore; other site 653045011743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011744 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 653045011745 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 653045011746 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 653045011747 active site 653045011748 substrate binding site [chemical binding]; other site 653045011749 cosubstrate binding site; other site 653045011750 catalytic site [active] 653045011751 Carboxy-terminal domain of Formyltransferase and similar domains; Region: FMT_C_like; cl14785 653045011752 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 653045011753 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011754 peptide synthase; Provisional; Region: PRK12467 653045011755 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011756 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045011757 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045011758 active site 653045011759 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045011760 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045011761 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045011762 putative NADP binding site [chemical binding]; other site 653045011763 active site 653045011764 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011765 thioester reductase domain; Region: Thioester-redct; TIGR01746 653045011766 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011767 NAD(P) binding site [chemical binding]; other site 653045011768 active site 653045011769 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045011770 Helix-turn-helix domains; Region: HTH; cl00088 653045011771 HTH-like domain; Region: HTH_21; pfam13276 653045011772 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 653045011773 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 653045011774 Integrase core domain; Region: rve; cl01316 653045011775 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 653045011776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045011777 Walker A motif; other site 653045011778 ATP binding site [chemical binding]; other site 653045011779 Walker B motif; other site 653045011780 arginine finger; other site 653045011781 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011782 AAA domain; Region: AAA_22; pfam13401 653045011783 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045011784 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045011786 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045011787 ATP binding site [chemical binding]; other site 653045011788 putative Mg++ binding site [ion binding]; other site 653045011789 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045011790 nucleotide binding region [chemical binding]; other site 653045011791 ATP-binding site [chemical binding]; other site 653045011792 Helicase associated domain; Region: HA; pfam03457 653045011793 Helicase associated domain; Region: HA; pfam03457 653045011794 Helicase associated domain; Region: HA; pfam03457 653045011795 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 653045011796 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 653045011797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045011798 active site 653045011799 DNA binding site [nucleotide binding] 653045011800 Int/Topo IB signature motif; other site 653045011801 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045011802 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045011803 Fatty acid desaturase; Region: FA_desaturase; pfam00487 653045011804 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 653045011805 putative di-iron ligands [ion binding]; other site 653045011806 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045011807 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 653045011808 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045011809 sequence-specific DNA binding site [nucleotide binding]; other site 653045011810 salt bridge; other site 653045011811 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 653045011812 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 653045011813 Helix-turn-helix domains; Region: HTH; cl00088 653045011814 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 653045011815 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 653045011816 catalytic residues [active] 653045011817 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045011818 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045011819 MULE transposase domain; Region: MULE; pfam10551 653045011820 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 653045011821 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011822 short chain dehydrogenase; Provisional; Region: PRK06197 653045011823 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 653045011824 putative NAD(P) binding site [chemical binding]; other site 653045011825 active site 653045011826 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045011827 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 653045011828 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045011829 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 653045011830 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 653045011831 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 653045011832 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045011833 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045011834 putative NAD(P) binding site [chemical binding]; other site 653045011835 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 653045011836 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 653045011837 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011838 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045011840 S-adenosylmethionine binding site [chemical binding]; other site 653045011841 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045011842 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045011843 Probable transposase; Region: OrfB_IS605; pfam01385 653045011844 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045011845 Transposase IS200 like; Region: Y1_Tnp; cl00848 653045011846 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 653045011847 Helix-turn-helix domains; Region: HTH; cl00088 653045011848 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045011849 dimerization interface [polypeptide binding]; other site 653045011850 substrate binding pocket [chemical binding]; other site 653045011851 short chain dehydrogenase; Provisional; Region: PRK06180 653045011852 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045011853 NADP binding site [chemical binding]; other site 653045011854 active site 653045011855 steroid binding site; other site 653045011856 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011857 NAD(P) binding site [chemical binding]; other site 653045011858 active site 653045011859 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045011860 Helix-turn-helix domains; Region: HTH; cl00088 653045011861 Helix-turn-helix domains; Region: HTH; cl00088 653045011862 Winged helix-turn helix; Region: HTH_29; pfam13551 653045011863 Helix-turn-helix domains; Region: HTH; cl00088 653045011864 Winged helix-turn helix; Region: HTH_33; pfam13592 653045011865 Integrase core domain; Region: rve; cl01316 653045011866 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045011867 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045011868 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 653045011869 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 653045011870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 653045011871 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 653045011872 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 653045011873 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 653045011874 putative DNA binding site [nucleotide binding]; other site 653045011875 putative homodimer interface [polypeptide binding]; other site 653045011876 peptide synthase; Provisional; Region: PRK12467 653045011877 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011878 peptide synthase; Provisional; Region: PRK12467 653045011879 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011880 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045011881 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045011882 AMP-binding enzyme; Region: AMP-binding; cl15778 653045011883 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 653045011884 putative catalytic residues [active] 653045011885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045011886 Helix-turn-helix domains; Region: HTH; cl00088 653045011887 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045011888 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045011889 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011890 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045011891 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045011892 active site 653045011893 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045011894 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045011895 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045011896 NADP binding site [chemical binding]; other site 653045011897 active site 653045011898 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011899 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045011900 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045011901 active site 653045011902 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045011903 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045011904 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045011905 putative NADP binding site [chemical binding]; other site 653045011906 active site 653045011907 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011908 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045011909 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045011910 active site 653045011911 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045011912 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045011913 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045011914 putative NADP binding site [chemical binding]; other site 653045011915 active site 653045011916 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045011917 Thioesterase; Region: PKS_TE; smart00824 653045011918 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 653045011919 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045011920 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 653045011921 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045011922 salt bridge; other site 653045011923 non-specific DNA binding site [nucleotide binding]; other site 653045011924 sequence-specific DNA binding site [nucleotide binding]; other site 653045011925 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045011926 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 653045011927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045011928 Helix-turn-helix domains; Region: HTH; cl00088 653045011929 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045011930 Isochorismatase family; Region: Isochorismatase; pfam00857 653045011931 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 653045011932 catalytic triad [active] 653045011933 conserved cis-peptide bond; other site 653045011934 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_5; cd07823 653045011935 putative hydrophobic ligand binding site [chemical binding]; other site 653045011936 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 653045011937 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045011938 catalytic loop [active] 653045011939 iron binding site [ion binding]; other site 653045011940 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045011941 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 653045011942 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045011943 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045011944 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 653045011945 benzoate transport; Region: 2A0115; TIGR00895 653045011946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011947 putative substrate translocation pore; other site 653045011948 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045011949 salicylate hydroxylase; Provisional; Region: PRK08163 653045011950 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045011951 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 653045011952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045011953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045011954 DNA binding site [nucleotide binding] 653045011955 domain linker motif; other site 653045011956 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045011957 ligand binding site [chemical binding]; other site 653045011958 dimerization interface [polypeptide binding]; other site 653045011959 Sodium:solute symporter family; Region: SSF; cl00456 653045011960 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 653045011961 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045011962 active site 653045011963 catalytic site [active] 653045011964 putative alpha-glucosidase; Provisional; Region: PRK10658 653045011965 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045011966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045011967 active site 653045011968 phosphorylation site [posttranslational modification] 653045011969 intermolecular recognition site; other site 653045011970 dimerization interface [polypeptide binding]; other site 653045011971 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045011972 DNA binding residues [nucleotide binding] 653045011973 dimerization interface [polypeptide binding]; other site 653045011974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045011975 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045011976 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045011977 classical (c) SDRs; Region: SDR_c; cd05233 653045011978 NAD(P) binding site [chemical binding]; other site 653045011979 active site 653045011980 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 653045011981 metal ion-dependent adhesion site (MIDAS); other site 653045011982 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 653045011983 TIGR03084 family protein; Region: TIGR03084 653045011984 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045011985 Wyosine base formation; Region: Wyosine_form; pfam08608 653045011986 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 653045011987 EamA-like transporter family; Region: EamA; cl01037 653045011988 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045011989 Helix-turn-helix domains; Region: HTH; cl00088 653045011990 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045011991 putative dimerization interface [polypeptide binding]; other site 653045011992 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 653045011993 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 653045011994 active site 653045011995 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 653045011996 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045011997 Helix-turn-helix domains; Region: HTH; cl00088 653045011998 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 653045011999 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045012000 The single-domain 2,3-dihydroxybiphenyl 1,2-dioxygenases (BphC, EC 1.13.11.39) from Rhodococcus globerulus P6, BphC2-RGP6 and BphC3-RGP6, and similar proteins; Region: BphC2-C3-RGP6_C_like; cd08348 653045012001 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045012002 putative active site [active] 653045012003 putative metal binding site [ion binding]; other site 653045012004 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045012005 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 653045012006 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045012007 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045012008 putative NAD(P) binding site [chemical binding]; other site 653045012009 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 653045012010 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045012013 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045012014 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045012015 Flavin Reductases; Region: FlaRed; cl00801 653045012016 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 653045012017 Prostaglandin dehydrogenases; Region: PGDH; cd05288 653045012018 NAD(P) binding site [chemical binding]; other site 653045012019 substrate binding site [chemical binding]; other site 653045012020 dimer interface [polypeptide binding]; other site 653045012021 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045012022 active site 653045012023 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 653045012024 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045012025 Helix-turn-helix domains; Region: HTH; cl00088 653045012026 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045012027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012028 dimer interface [polypeptide binding]; other site 653045012029 conserved gate region; other site 653045012030 putative PBP binding loops; other site 653045012031 ABC-ATPase subunit interface; other site 653045012032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045012033 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045012034 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045012035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045012036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045012037 DNA binding site [nucleotide binding] 653045012038 domain linker motif; other site 653045012039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045012040 dimerization interface [polypeptide binding]; other site 653045012041 ligand binding site [chemical binding]; other site 653045012042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012043 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 653045012044 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 653045012045 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 653045012046 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 653045012047 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 653045012048 putative dimer interface [polypeptide binding]; other site 653045012049 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045012050 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045012051 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 653045012052 homotrimer interaction site [polypeptide binding]; other site 653045012053 putative active site [active] 653045012054 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045012055 Helix-turn-helix domains; Region: HTH; cl00088 653045012056 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045012057 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045012058 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 653045012059 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 653045012060 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 653045012061 Protein of unknown function (DUF556); Region: DUF556; cl00822 653045012062 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045012063 Streptomyces aureofaciens putative aldehyde dehydrogenase AldA (AAD23400)-like; Region: ALDH_AldA-AAD23400; cd07106 653045012064 NAD(P) binding site [chemical binding]; other site 653045012065 catalytic residues [active] 653045012066 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 653045012067 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 653045012068 catalytic Zn binding site [ion binding]; other site 653045012069 NAD binding site [chemical binding]; other site 653045012070 structural Zn binding site [ion binding]; other site 653045012071 Leucine carboxyl methyltransferase; Region: LCM; cl01306 653045012072 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 653045012073 active site 653045012074 catalytic triad [active] 653045012075 oxyanion hole [active] 653045012076 Helix-turn-helix domains; Region: HTH; cl00088 653045012077 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 653045012078 homotrimer interaction site [polypeptide binding]; other site 653045012079 putative active site [active] 653045012080 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045012081 Helix-turn-helix domains; Region: HTH; cl00088 653045012082 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045012083 classical (c) SDRs; Region: SDR_c; cd05233 653045012084 NAD(P) binding site [chemical binding]; other site 653045012085 active site 653045012086 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 653045012087 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes Similar to D-Serine Dehydratase and D-Threonine Aldolase, Unknown Group 1; Region: PLPDE_III_DSD_D-TA_like_1; cd06812 653045012088 dimer interface [polypeptide binding]; other site 653045012089 active site 653045012090 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045012091 substrate binding site [chemical binding]; other site 653045012092 catalytic residue [active] 653045012093 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 653045012094 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045012095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012096 dimer interface [polypeptide binding]; other site 653045012097 conserved gate region; other site 653045012098 putative PBP binding loops; other site 653045012099 ABC-ATPase subunit interface; other site 653045012100 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 653045012101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012102 dimer interface [polypeptide binding]; other site 653045012103 conserved gate region; other site 653045012104 putative PBP binding loops; other site 653045012105 ABC-ATPase subunit interface; other site 653045012106 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 653045012107 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045012108 Walker A/P-loop; other site 653045012109 ATP binding site [chemical binding]; other site 653045012110 Q-loop/lid; other site 653045012111 ABC transporter signature motif; other site 653045012112 Walker B; other site 653045012113 D-loop; other site 653045012114 H-loop/switch region; other site 653045012115 TOBE domain; Region: TOBE_2; cl01440 653045012116 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 653045012117 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045012118 active site 653045012119 TDP-binding site; other site 653045012120 acceptor substrate-binding pocket; other site 653045012121 homodimer interface [polypeptide binding]; other site 653045012122 NMT1/THI5 like; Region: NMT1; pfam09084 653045012123 NMT1-like family; Region: NMT1_2; cl15260 653045012124 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045012125 nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184 653045012126 Walker A/P-loop; other site 653045012127 ATP binding site [chemical binding]; other site 653045012128 Q-loop/lid; other site 653045012129 ABC transporter signature motif; other site 653045012130 Walker B; other site 653045012131 D-loop; other site 653045012132 H-loop/switch region; other site 653045012133 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045012134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012135 dimer interface [polypeptide binding]; other site 653045012136 conserved gate region; other site 653045012137 putative PBP binding loops; other site 653045012138 ABC-ATPase subunit interface; other site 653045012139 Dihydroorotase and related cyclic amidohydrolases [Nucleotide transport and metabolism]; Region: PyrC; COG0044 653045012140 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045012141 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045012142 active site 653045012143 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045012144 Pirin-related protein [General function prediction only]; Region: COG1741 653045012145 Cupin domain; Region: Cupin_2; cl09118 653045012146 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045012147 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 653045012148 Walker A/P-loop; other site 653045012149 ATP binding site [chemical binding]; other site 653045012150 Q-loop/lid; other site 653045012151 ABC transporter signature motif; other site 653045012152 Walker B; other site 653045012153 D-loop; other site 653045012154 H-loop/switch region; other site 653045012155 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 653045012156 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 653045012157 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045012158 substrate binding pocket [chemical binding]; other site 653045012159 chain length determination region; other site 653045012160 substrate-Mg2+ binding site; other site 653045012161 catalytic residues [active] 653045012162 aspartate-rich region 1; other site 653045012163 active site lid residues [active] 653045012164 aspartate-rich region 2; other site 653045012165 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045012166 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045012167 DNA-binding site [nucleotide binding]; DNA binding site 653045012168 FCD domain; Region: FCD; cl11656 653045012169 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 653045012170 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 653045012171 Sulfatase; Region: Sulfatase; cl10460 653045012172 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045012173 classical (c) SDRs; Region: SDR_c; cd05233 653045012174 NAD(P) binding site [chemical binding]; other site 653045012175 active site 653045012176 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045012177 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045012178 NAD(P) binding site [chemical binding]; other site 653045012179 catalytic residues [active] 653045012180 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 653045012181 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045012182 Walker A/P-loop; other site 653045012183 ATP binding site [chemical binding]; other site 653045012184 Q-loop/lid; other site 653045012185 ABC transporter signature motif; other site 653045012186 Walker B; other site 653045012187 D-loop; other site 653045012188 H-loop/switch region; other site 653045012189 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045012190 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045012191 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045012192 Walker A/P-loop; other site 653045012193 ATP binding site [chemical binding]; other site 653045012194 Q-loop/lid; other site 653045012195 ABC transporter signature motif; other site 653045012196 Walker B; other site 653045012197 D-loop; other site 653045012198 H-loop/switch region; other site 653045012199 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045012200 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 653045012201 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012202 dimer interface [polypeptide binding]; other site 653045012203 conserved gate region; other site 653045012204 putative PBP binding loops; other site 653045012205 ABC-ATPase subunit interface; other site 653045012206 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 653045012207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012208 dimer interface [polypeptide binding]; other site 653045012209 conserved gate region; other site 653045012210 ABC-ATPase subunit interface; other site 653045012211 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 653045012212 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045012213 tartrate dehydrogenase; Provisional; Region: PRK08194 653045012214 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 653045012215 amidase; Provisional; Region: PRK07042 653045012216 Amidase; Region: Amidase; cl11426 653045012217 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045012218 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045012219 DNA-binding site [nucleotide binding]; DNA binding site 653045012220 FCD domain; Region: FCD; cl11656 653045012221 MoxR-like ATPases [General function prediction only]; Region: COG0714 653045012222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045012223 Walker A motif; other site 653045012224 ATP binding site [chemical binding]; other site 653045012225 Walker B motif; other site 653045012226 arginine finger; other site 653045012227 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 653045012228 metal ion-dependent adhesion site (MIDAS); other site 653045012229 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 653045012230 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045012231 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045012232 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045012233 Peptidase family M23; Region: Peptidase_M23; pfam01551 653045012234 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 653045012235 active site 653045012236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045012237 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045012238 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045012239 dimer interface [polypeptide binding]; other site 653045012240 phosphorylation site [posttranslational modification] 653045012241 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045012242 ATP binding site [chemical binding]; other site 653045012243 Mg2+ binding site [ion binding]; other site 653045012244 G-X-G motif; other site 653045012245 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045012246 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045012247 active site 653045012248 phosphorylation site [posttranslational modification] 653045012249 intermolecular recognition site; other site 653045012250 dimerization interface [polypeptide binding]; other site 653045012251 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045012252 DNA binding site [nucleotide binding] 653045012253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045012254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045012255 dimerization interface [polypeptide binding]; other site 653045012256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045012257 ATP binding site [chemical binding]; other site 653045012258 Mg2+ binding site [ion binding]; other site 653045012259 G-X-G motif; other site 653045012260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045012261 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045012262 Walker A/P-loop; other site 653045012263 ATP binding site [chemical binding]; other site 653045012264 Q-loop/lid; other site 653045012265 ABC transporter signature motif; other site 653045012266 Walker B; other site 653045012267 D-loop; other site 653045012268 H-loop/switch region; other site 653045012269 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045012270 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045012271 Walker A/P-loop; other site 653045012272 ATP binding site [chemical binding]; other site 653045012273 Q-loop/lid; other site 653045012274 ABC transporter signature motif; other site 653045012275 Walker B; other site 653045012276 D-loop; other site 653045012277 H-loop/switch region; other site 653045012278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045012279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045012280 active site 653045012281 phosphorylation site [posttranslational modification] 653045012282 intermolecular recognition site; other site 653045012283 dimerization interface [polypeptide binding]; other site 653045012284 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045012285 DNA binding site [nucleotide binding] 653045012286 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045012287 Helix-turn-helix domains; Region: HTH; cl00088 653045012288 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 653045012289 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045012290 putative NAD(P) binding site [chemical binding]; other site 653045012291 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045012292 Helix-turn-helix domains; Region: HTH; cl00088 653045012293 Protein of unknown function (DUF998); Region: DUF998; pfam06197 653045012294 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012295 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045012296 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 653045012297 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045012298 active site 653045012299 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045012300 S-adenosylmethionine binding site [chemical binding]; other site 653045012301 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 653045012302 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 653045012303 Helix-turn-helix domains; Region: HTH; cl00088 653045012304 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045012305 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045012306 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012307 NAD(P) binding site [chemical binding]; other site 653045012308 active site 653045012309 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 653045012310 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012311 CoA-ligase; Region: Ligase_CoA; cl02894 653045012312 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045012313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045012314 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 653045012315 active site 653045012316 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045012317 substrate binding site [chemical binding]; other site 653045012318 oxyanion hole (OAH) forming residues; other site 653045012319 trimer interface [polypeptide binding]; other site 653045012320 Sodium:solute symporter family; Region: SSF; cl00456 653045012321 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045012322 Leucine carboxyl methyltransferase; Region: LCM; cl01306 653045012323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045012324 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 653045012325 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 653045012326 Cupin domain; Region: Cupin_2; cl09118 653045012327 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045012328 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 653045012329 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045012330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045012331 homodimer interface [polypeptide binding]; other site 653045012332 catalytic residue [active] 653045012333 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045012334 extended (e) SDRs; Region: SDR_e; cd08946 653045012335 NAD(P) binding site [chemical binding]; other site 653045012336 active site 653045012337 substrate binding site [chemical binding]; other site 653045012338 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045012339 AMP-binding enzyme; Region: AMP-binding; cl15778 653045012340 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045012341 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 653045012342 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045012343 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045012344 classical (c) SDRs; Region: SDR_c; cd05233 653045012345 NAD(P) binding site [chemical binding]; other site 653045012346 active site 653045012347 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045012348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012349 putative substrate translocation pore; other site 653045012350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012351 Agrobacterium tumefaciens protein Atu4866; Region: Atu4866; pfam11512 653045012352 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045012353 salt bridge; other site 653045012354 non-specific DNA binding site [nucleotide binding]; other site 653045012355 sequence-specific DNA binding site [nucleotide binding]; other site 653045012356 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012357 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 653045012358 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 653045012359 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045012360 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045012361 conserved cys residue [active] 653045012362 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045012363 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 653045012364 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045012365 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 653045012366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045012367 S-adenosylmethionine binding site [chemical binding]; other site 653045012368 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012369 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045012370 NAD(P) binding site [chemical binding]; other site 653045012371 active site 653045012372 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045012373 classical (c) SDRs; Region: SDR_c; cd05233 653045012374 NAD(P) binding site [chemical binding]; other site 653045012375 active site 653045012376 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045012377 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 653045012378 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045012379 Helix-turn-helix domains; Region: HTH; cl00088 653045012380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012381 putative substrate translocation pore; other site 653045012382 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045012384 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045012385 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045012386 active site 653045012387 metal binding site [ion binding]; metal-binding site 653045012388 Helix-turn-helix domains; Region: HTH; cl00088 653045012389 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 653045012390 YceI-like domain; Region: YceI; cl01001 653045012391 Helix-turn-helix domains; Region: HTH; cl00088 653045012392 WHG domain; Region: WHG; pfam13305 653045012393 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_6; cd01844 653045012394 active site 653045012395 catalytic triad [active] 653045012396 oxyanion hole [active] 653045012397 Low molecular weight phosphatase family; Region: LMWPc; cd00115 653045012398 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 653045012399 active site 653045012400 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045012401 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 653045012402 putative catalytic site [active] 653045012403 putative metal binding site [ion binding]; other site 653045012404 putative phosphate binding site [ion binding]; other site 653045012405 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045012406 Helix-turn-helix domains; Region: HTH; cl00088 653045012407 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045012408 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045012409 DNA binding site [nucleotide binding] 653045012410 domain linker motif; other site 653045012411 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045012412 ligand binding site [chemical binding]; other site 653045012413 dimerization interface [polypeptide binding]; other site 653045012414 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 653045012415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012416 Alginate lyase; Region: Alginate_lyase2; pfam08787 653045012417 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 653045012418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012419 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 653045012420 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 653045012421 intersubunit interface [polypeptide binding]; other site 653045012422 active site 653045012423 Zn2+ binding site [ion binding]; other site 653045012424 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 653045012425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012426 putative substrate translocation pore; other site 653045012427 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 653045012428 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045012429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012430 NAD(P) binding site [chemical binding]; other site 653045012431 active site 653045012432 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045012433 DNA-binding site [nucleotide binding]; DNA binding site 653045012434 FCD domain; Region: FCD; cl11656 653045012435 Helix-turn-helix domains; Region: HTH; cl00088 653045012436 WYL domain; Region: WYL; cl14852 653045012437 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045012438 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045012439 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045012440 active site 653045012441 catalytic tetrad [active] 653045012442 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 653045012443 OpgC protein; Region: OpgC_C; cl00792 653045012444 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 653045012445 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045012446 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045012447 catalytic residue [active] 653045012448 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 653045012449 Rrf2 family protein; Region: rrf2_super; TIGR00738 653045012450 Helix-turn-helix domains; Region: HTH; cl00088 653045012451 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 653045012452 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 653045012453 heme-binding site [chemical binding]; other site 653045012454 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 653045012455 FAD binding pocket [chemical binding]; other site 653045012456 FAD binding motif [chemical binding]; other site 653045012457 phosphate binding motif [ion binding]; other site 653045012458 beta-alpha-beta structure motif; other site 653045012459 NAD binding pocket [chemical binding]; other site 653045012460 Heme binding pocket [chemical binding]; other site 653045012461 Leucine carboxyl methyltransferase; Region: LCM; cl01306 653045012462 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045012463 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 653045012464 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045012465 DNA binding residues [nucleotide binding] 653045012466 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 653045012467 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045012468 yiaA/B two helix domain; Region: YiaAB; cl01759 653045012469 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045012470 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045012471 DNA binding site [nucleotide binding] 653045012472 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045012473 dimerization interface [polypeptide binding]; other site 653045012474 ligand binding site [chemical binding]; other site 653045012475 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 653045012476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012477 putative substrate translocation pore; other site 653045012478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012479 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045012480 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012481 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045012482 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 653045012483 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 653045012484 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 653045012485 Metal-binding active site; metal-binding site 653045012486 AP (apurinic/apyrimidinic) site pocket; other site 653045012487 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045012488 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045012489 tetracycline repressor protein TetR; Provisional; Region: PRK13756 653045012490 Helix-turn-helix domains; Region: HTH; cl00088 653045012491 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045012492 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 653045012493 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012494 putative substrate translocation pore; other site 653045012495 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045012496 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 653045012497 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 653045012498 catalytic loop [active] 653045012499 iron binding site [ion binding]; other site 653045012500 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045012501 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 653045012502 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 653045012503 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 653045012504 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045012505 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045012506 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045012507 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 653045012508 [2Fe-2S] cluster binding site [ion binding]; other site 653045012509 Cytochrome P450; Region: p450; pfam00067 653045012510 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045012511 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045012512 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 653045012513 active site 653045012514 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045012515 1-cyclohexenylcarbonyl_coenzyme A_reductase (ChcA)_like, classical (c) SDRs; Region: ChcA_like_SDR_c; cd05359 653045012516 putative NAD(P) binding site [chemical binding]; other site 653045012517 active site 653045012518 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 653045012519 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045012520 active site 653045012521 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045012522 active site 653045012523 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012524 NAD(P) binding site [chemical binding]; other site 653045012525 active site 653045012526 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045012527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045012529 putative substrate translocation pore; other site 653045012530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012531 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 653045012532 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 653045012533 putative NAD(P) binding site [chemical binding]; other site 653045012534 catalytic Zn binding site [ion binding]; other site 653045012535 structural Zn binding site [ion binding]; other site 653045012536 Helix-turn-helix domains; Region: HTH; cl00088 653045012537 WHG domain; Region: WHG; pfam13305 653045012538 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045012539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045012540 Helix-turn-helix domains; Region: HTH; cl00088 653045012541 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268 653045012542 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045012543 putative NAD(P) binding site [chemical binding]; other site 653045012544 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 653045012545 SCP-2 sterol transfer family; Region: SCP2; cl01225 653045012546 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 653045012547 active site 653045012548 RNA/DNA hybrid binding site [nucleotide binding]; other site 653045012549 Endonuclease I; Region: Endonuclease_1; cl01003 653045012550 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 653045012551 conserved cys residue [active] 653045012552 ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351 653045012553 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045012554 metal binding site [ion binding]; metal-binding site 653045012555 Predicted transcriptional regulator [Transcription]; Region: COG1959 653045012556 Helix-turn-helix domains; Region: HTH; cl00088 653045012557 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045012558 classical (c) SDRs; Region: SDR_c; cd05233 653045012559 NAD(P) binding site [chemical binding]; other site 653045012560 active site 653045012561 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045012562 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 653045012563 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 653045012564 AlkA N-terminal domain; Region: AlkA_N; cl05528 653045012565 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 653045012566 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 653045012567 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 653045012568 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045012569 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 653045012570 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045012571 carotene biosynthesis associated membrane protein; Region: crt_membr; TIGR03459 653045012572 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 653045012573 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 653045012574 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 653045012575 putative active site [active] 653045012576 putative metal binding site [ion binding]; other site 653045012577 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 653045012578 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045012579 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045012580 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045012581 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045012582 phospholipase C, phosphocholine-specific, Pseudomonas-type; Region: PC_PLC; TIGR03396 653045012583 Phosphoesterase family; Region: Phosphoesterase; cl15450 653045012584 Domain of unknown function (DUF756); Region: DUF756; pfam05506 653045012585 Domain of unknown function (DUF756); Region: DUF756; pfam05506 653045012586 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 653045012587 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 653045012588 Flavoprotein; Region: Flavoprotein; cl08021 653045012589 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 653045012590 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045012591 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045012592 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 653045012593 Helix-turn-helix domains; Region: HTH; cl00088 653045012594 Right handed beta helix region; Region: Beta_helix; pfam13229 653045012595 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045012596 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 653045012597 metal binding site [ion binding]; metal-binding site 653045012598 ligand binding site [chemical binding]; other site 653045012599 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 653045012600 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045012601 Walker A/P-loop; other site 653045012602 ATP binding site [chemical binding]; other site 653045012603 Q-loop/lid; other site 653045012604 ABC transporter signature motif; other site 653045012605 Walker B; other site 653045012606 D-loop; other site 653045012607 H-loop/switch region; other site 653045012608 benzoylformate decarboxylase; Reviewed; Region: PRK07092 653045012609 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 653045012610 PYR/PP interface [polypeptide binding]; other site 653045012611 dimer interface [polypeptide binding]; other site 653045012612 TPP binding site [chemical binding]; other site 653045012613 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045012614 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 653045012615 TPP-binding site [chemical binding]; other site 653045012616 dimer interface [polypeptide binding]; other site 653045012617 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045012618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045012619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045012620 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045012621 substrate binding pocket [chemical binding]; other site 653045012622 membrane-bound complex binding site; other site 653045012623 hinge residues; other site 653045012624 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 653045012625 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045012626 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045012627 DinB superfamily; Region: DinB_2; pfam12867 653045012628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045012629 dimerization interface [polypeptide binding]; other site 653045012630 putative DNA binding site [nucleotide binding]; other site 653045012631 putative Zn2+ binding site [ion binding]; other site 653045012632 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 653045012633 putative hydrophobic ligand binding site [chemical binding]; other site 653045012634 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 653045012635 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 653045012636 Protein of unknown function DUF89; Region: DUF89; cl15397 653045012637 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 653045012638 Phosphate transporter family; Region: PHO4; cl00396 653045012639 hypothetical protein; Provisional; Region: PRK07538 653045012640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012641 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045012642 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 653045012643 Helix-turn-helix domains; Region: HTH; cl00088 653045012644 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 653045012645 putative dimerization interface [polypeptide binding]; other site 653045012646 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 653045012647 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 653045012648 Helix-turn-helix domains; Region: HTH; cl00088 653045012649 DNA binding site [nucleotide binding] 653045012650 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045012651 NB-ARC domain; Region: NB-ARC; pfam00931 653045012652 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045012653 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045012654 binding surface 653045012655 TPR motif; other site 653045012656 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045012657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045012658 binding surface 653045012659 TPR motif; other site 653045012660 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045012661 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045012662 MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417 653045012663 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045012664 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 653045012665 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 653045012666 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 653045012667 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 653045012668 NMT1-like family; Region: NMT1_2; cl15260 653045012669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045012670 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045012671 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 653045012672 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045012673 Walker A/P-loop; other site 653045012674 ATP binding site [chemical binding]; other site 653045012675 Q-loop/lid; other site 653045012676 ABC transporter signature motif; other site 653045012677 Walker B; other site 653045012678 D-loop; other site 653045012679 H-loop/switch region; other site 653045012680 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045012681 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045012682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045012683 ATP binding site [chemical binding]; other site 653045012684 Mg2+ binding site [ion binding]; other site 653045012685 G-X-G motif; other site 653045012686 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 653045012687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045012688 active site 653045012689 phosphorylation site [posttranslational modification] 653045012690 intermolecular recognition site; other site 653045012691 dimerization interface [polypeptide binding]; other site 653045012692 Helix-turn-helix domains; Region: HTH; cl00088 653045012693 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 653045012694 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045012696 S-adenosylmethionine binding site [chemical binding]; other site 653045012697 BNR repeat-like domain; Region: BNR_2; pfam13088 653045012698 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 653045012699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012700 NAD(P) binding site [chemical binding]; other site 653045012701 active site 653045012702 D-cysteine desulfhydrase; Validated; Region: PRK03910 653045012703 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 653045012704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045012705 catalytic residue [active] 653045012706 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 653045012707 Dak1 domain; Region: Dak1; pfam02733 653045012708 DAK2 domain; Region: Dak2; cl03685 653045012709 OpgC protein; Region: OpgC_C; cl00792 653045012710 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045012711 S-adenosylmethionine binding site [chemical binding]; other site 653045012712 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 653045012713 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045012714 sequence-specific DNA binding site [nucleotide binding]; other site 653045012715 salt bridge; other site 653045012716 Cupin domain; Region: Cupin_2; cl09118 653045012717 Cupin domain; Region: Cupin_2; cl09118 653045012718 Predicted transcriptional regulator [Transcription]; Region: COG1959 653045012719 Helix-turn-helix domains; Region: HTH; cl00088 653045012720 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 653045012721 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045012722 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045012723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045012724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012725 dimer interface [polypeptide binding]; other site 653045012726 conserved gate region; other site 653045012727 putative PBP binding loops; other site 653045012728 ABC-ATPase subunit interface; other site 653045012729 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045012730 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045012731 Walker A/P-loop; other site 653045012732 ATP binding site [chemical binding]; other site 653045012733 Q-loop/lid; other site 653045012734 ABC transporter signature motif; other site 653045012735 Walker B; other site 653045012736 D-loop; other site 653045012737 H-loop/switch region; other site 653045012738 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045012739 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 653045012740 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 653045012741 Walker A/P-loop; other site 653045012742 ATP binding site [chemical binding]; other site 653045012743 Q-loop/lid; other site 653045012744 ABC transporter signature motif; other site 653045012745 Walker B; other site 653045012746 D-loop; other site 653045012747 H-loop/switch region; other site 653045012748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 653045012749 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 653045012750 active site 653045012751 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 653045012752 dimer interface [polypeptide binding]; other site 653045012753 non-prolyl cis peptide bond; other site 653045012754 insertion regions; other site 653045012755 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045012756 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045012757 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 653045012758 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045012759 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045012760 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 653045012761 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 653045012762 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 653045012763 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045012764 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045012765 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 653045012766 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 653045012767 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 653045012768 Cation efflux family; Region: Cation_efflux; cl00316 653045012769 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 653045012770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045012771 motif II; other site 653045012772 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045012773 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045012774 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045012775 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045012776 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045012777 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045012778 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045012779 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045012780 active site 653045012781 ATP binding site [chemical binding]; other site 653045012782 substrate binding site [chemical binding]; other site 653045012783 activation loop (A-loop); other site 653045012784 FG-GAP repeat; Region: FG-GAP; cl15299 653045012785 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 653045012786 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045012787 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 653045012788 iron-sulfur cluster [ion binding]; other site 653045012789 [2Fe-2S] cluster binding site [ion binding]; other site 653045012790 Dienelactone hydrolase family; Region: DLH; pfam01738 653045012791 Domain of unknown function (DUF385); Region: DUF385; cl04387 653045012792 heat shock protein 90; Provisional; Region: PRK05218 653045012793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045012794 ATP binding site [chemical binding]; other site 653045012795 Mg2+ binding site [ion binding]; other site 653045012796 G-X-G motif; other site 653045012797 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045012798 Helix-turn-helix domains; Region: HTH; cl00088 653045012799 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 653045012800 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 653045012801 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045012802 catalytic residue [active] 653045012803 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 653045012804 dimer interface [polypeptide binding]; other site 653045012805 First Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt1; cd04772 653045012806 DNA binding residues [nucleotide binding] 653045012807 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045012808 putative dimer interface [polypeptide binding]; other site 653045012809 Second Helix-Turn-Helix DNA binding domain of the regulatory protein TioE; Region: HTH_TioE_rpt2; cd04773 653045012810 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045012811 DNA binding residues [nucleotide binding] 653045012812 putative dimer interface [polypeptide binding]; other site 653045012813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045012814 Walker A/P-loop; other site 653045012815 ATP binding site [chemical binding]; other site 653045012816 Q-loop/lid; other site 653045012817 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 653045012818 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045012819 Walker A/P-loop; other site 653045012820 ATP binding site [chemical binding]; other site 653045012821 Q-loop/lid; other site 653045012822 ABC transporter signature motif; other site 653045012823 Walker B; other site 653045012824 D-loop; other site 653045012825 H-loop/switch region; other site 653045012826 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 653045012827 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 653045012828 active site 653045012829 phosphorylation site [posttranslational modification] 653045012830 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 653045012831 active site 653045012832 P-loop; other site 653045012833 phosphorylation site [posttranslational modification] 653045012834 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045012835 Sodium:solute symporter family; Region: SSF; cl00456 653045012836 Sodium:solute symporter family; Region: SSF; cl00456 653045012837 Helix-turn-helix domains; Region: HTH; cl00088 653045012838 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 653045012839 Chitin binding domain; Region: Chitin_bind_3; cl03871 653045012840 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 653045012841 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 653045012842 substrate binding pocket [chemical binding]; other site 653045012843 active site 653045012844 iron coordination sites [ion binding]; other site 653045012845 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 653045012846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012848 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 653045012849 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 653045012850 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 653045012851 UbiA prenyltransferase family; Region: UbiA; cl00337 653045012852 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045012853 substrate binding pocket [chemical binding]; other site 653045012854 chain length determination region; other site 653045012855 substrate-Mg2+ binding site; other site 653045012856 catalytic residues [active] 653045012857 aspartate-rich region 1; other site 653045012858 active site lid residues [active] 653045012859 aspartate-rich region 2; other site 653045012860 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045012861 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 653045012862 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045012863 homodimer interface [polypeptide binding]; other site 653045012864 catalytic residue [active] 653045012865 Helix-turn-helix domains; Region: HTH; cl00088 653045012866 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045012867 putative dimerization interface [polypeptide binding]; other site 653045012868 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 653045012869 putative catalytic site [active] 653045012870 putative metal binding site [ion binding]; other site 653045012871 putative phosphate binding site [ion binding]; other site 653045012872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045012873 Mechanosensitive ion channel; Region: MS_channel; pfam00924 653045012874 transcriptional regulator NarL; Provisional; Region: PRK10651 653045012875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045012876 active site 653045012877 phosphorylation site [posttranslational modification] 653045012878 intermolecular recognition site; other site 653045012879 dimerization interface [polypeptide binding]; other site 653045012880 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045012881 DNA binding residues [nucleotide binding] 653045012882 dimerization interface [polypeptide binding]; other site 653045012883 Histidine kinase; Region: HisKA_3; pfam07730 653045012884 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045012885 ATP binding site [chemical binding]; other site 653045012886 Mg2+ binding site [ion binding]; other site 653045012887 G-X-G motif; other site 653045012888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045012889 S-adenosylmethionine binding site [chemical binding]; other site 653045012890 Ribosomally synthesized peptide in Streptomyces species; Region: Strep_pep; pfam14404 653045012891 Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189 653045012892 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 653045012893 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 653045012894 Protein of unknown function (DUF1266); Region: DUF1266; cl14673 653045012895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012896 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 653045012897 pyruvate carboxylase; Reviewed; Region: PRK12999 653045012898 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 653045012899 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045012900 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 653045012901 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 653045012902 active site 653045012903 catalytic residues [active] 653045012904 metal binding site [ion binding]; metal-binding site 653045012905 homodimer binding site [polypeptide binding]; other site 653045012906 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 653045012907 carboxyltransferase (CT) interaction site; other site 653045012908 biotinylation site [posttranslational modification]; other site 653045012909 Helix-turn-helix domains; Region: HTH; cl00088 653045012910 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 653045012911 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 653045012912 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045012913 Helix-turn-helix domains; Region: HTH; cl00088 653045012914 WHG domain; Region: WHG; pfam13305 653045012915 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045012916 active site 653045012917 metal binding site [ion binding]; metal-binding site 653045012918 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 653045012919 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 653045012920 Right handed beta helix region; Region: Beta_helix; pfam13229 653045012921 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 653045012922 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045012923 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012924 dimer interface [polypeptide binding]; other site 653045012925 conserved gate region; other site 653045012926 putative PBP binding loops; other site 653045012927 ABC-ATPase subunit interface; other site 653045012928 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 653045012929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045012930 dimer interface [polypeptide binding]; other site 653045012931 conserved gate region; other site 653045012932 putative PBP binding loops; other site 653045012933 ABC-ATPase subunit interface; other site 653045012934 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045012935 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045012936 muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534 653045012937 metal binding site [ion binding]; metal-binding site 653045012938 substrate binding pocket [chemical binding]; other site 653045012939 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 653045012940 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012941 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 653045012942 Helix-turn-helix domains; Region: HTH; cl00088 653045012943 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045012944 dimerization interface [polypeptide binding]; other site 653045012945 Domain of unknown function (DUF305); Region: DUF305; cl15795 653045012946 Domain of unknown function (DUF4388); Region: DUF4388; pfam14332 653045012947 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045012948 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 653045012949 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 653045012950 active site 653045012951 tetramer interface [polypeptide binding]; other site 653045012952 GntP family permease; Region: GntP_permease; pfam02447 653045012953 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 653045012954 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 653045012955 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 653045012956 active site pocket [active] 653045012957 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 653045012958 Helix-turn-helix domains; Region: HTH; cl00088 653045012959 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to regulators involved in the catabolism of aromatic compounds, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like_1; cd08447 653045012960 putative dimerization interface [polypeptide binding]; other site 653045012961 putative substrate binding pocket [chemical binding]; other site 653045012962 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 653045012963 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045012964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045012965 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045012966 Helix-turn-helix domains; Region: HTH; cl00088 653045012967 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045012968 glycerol kinase; Provisional; Region: glpK; PRK00047 653045012969 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 653045012970 N- and C-terminal domain interface [polypeptide binding]; other site 653045012971 putative active site [active] 653045012972 putative MgATP binding site [chemical binding]; other site 653045012973 catalytic site [active] 653045012974 metal binding site [ion binding]; metal-binding site 653045012975 putative homotetramer interface [polypeptide binding]; other site 653045012976 putative glycerol binding site [chemical binding]; other site 653045012977 homodimer interface [polypeptide binding]; other site 653045012978 Bacitracin resistance protein BacA; Region: BacA; cl00858 653045012979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045012980 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045012981 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 653045012982 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045012983 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045012984 Probable transposase; Region: OrfB_IS605; pfam01385 653045012985 Helix-turn-helix domains; Region: HTH; cl00088 653045012986 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045012987 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045012988 NAD(P) binding site [chemical binding]; other site 653045012989 active site 653045012990 tyramine oxidase; Provisional; Region: tynA; PRK11504 653045012991 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 653045012992 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 653045012993 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045012994 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045012995 AMP-binding enzyme; Region: AMP-binding; cl15778 653045012996 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045012997 peptide synthase; Provisional; Region: PRK12316 653045012998 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045012999 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013000 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013001 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045013002 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013003 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013004 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013005 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013006 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045013007 peptide synthase; Provisional; Region: PRK12467 653045013008 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013009 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013010 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013011 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045013012 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013013 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013014 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013015 peptide synthase; Provisional; Region: PRK12316 653045013016 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013017 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013018 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013019 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045013020 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013021 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013022 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013023 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013024 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013025 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013026 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045013027 peptide synthase; Provisional; Region: PRK12467 653045013028 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013029 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013030 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013031 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013032 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013033 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013034 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045013035 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045013036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 653045013037 MbtH-like protein; Region: MbtH; cl01279 653045013038 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045013039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045013040 S-adenosylmethionine binding site [chemical binding]; other site 653045013041 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 653045013042 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045013043 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 653045013044 Helix-turn-helix domains; Region: HTH; cl00088 653045013045 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 653045013046 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849 653045013047 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 653045013048 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 653045013049 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 653045013050 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013051 Family description; Region: UvrD_C_2; cl15862 653045013052 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045013053 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 653045013054 putative NAD(P) binding site [chemical binding]; other site 653045013055 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045013056 Helix-turn-helix domains; Region: HTH; cl00088 653045013057 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 653045013058 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045013059 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045013060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045013061 putative substrate translocation pore; other site 653045013062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045013063 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 653045013064 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045013065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013066 Walker A/P-loop; other site 653045013067 ATP binding site [chemical binding]; other site 653045013068 Q-loop/lid; other site 653045013069 ABC transporter signature motif; other site 653045013070 Walker B; other site 653045013071 D-loop; other site 653045013072 H-loop/switch region; other site 653045013073 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 653045013074 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 653045013075 putative active site [active] 653045013076 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045013077 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013078 Walker A/P-loop; other site 653045013079 ATP binding site [chemical binding]; other site 653045013080 Q-loop/lid; other site 653045013081 ABC transporter signature motif; other site 653045013082 Walker B; other site 653045013083 D-loop; other site 653045013084 H-loop/switch region; other site 653045013085 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 653045013086 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 653045013087 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 653045013088 putative dimer interface [polypeptide binding]; other site 653045013089 N-terminal domain interface [polypeptide binding]; other site 653045013090 putative substrate binding pocket (H-site) [chemical binding]; other site 653045013091 EamA-like transporter family; Region: EamA; cl01037 653045013092 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045013093 Helix-turn-helix domains; Region: HTH; cl00088 653045013094 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045013095 NlpC/P60 family; Region: NLPC_P60; cl11438 653045013096 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045013097 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045013098 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 653045013099 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 653045013100 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045013101 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045013102 classical (c) SDRs; Region: SDR_c; cd05233 653045013103 NAD(P) binding site [chemical binding]; other site 653045013104 active site 653045013105 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045013106 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 653045013107 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045013108 active site 653045013109 TDP-binding site; other site 653045013110 acceptor substrate-binding pocket; other site 653045013111 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045013112 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045013113 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045013114 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013115 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045013116 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013117 active site 653045013118 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013119 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045013120 phosphate binding site [ion binding]; other site 653045013121 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 653045013122 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045013123 phosphate binding site [ion binding]; other site 653045013124 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013125 active site 653045013126 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013127 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013128 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013129 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 653045013130 putative NADP binding site [chemical binding]; other site 653045013131 active site 653045013132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 653045013133 active site 653045013134 Erythromycin esterase homolog [General function prediction only]; Region: COG2312 653045013135 Erythromycin esterase; Region: Erythro_esteras; pfam05139 653045013136 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013137 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 653045013138 Walker A/P-loop; other site 653045013139 ATP binding site [chemical binding]; other site 653045013140 Q-loop/lid; other site 653045013141 ABC transporter signature motif; other site 653045013142 Walker B; other site 653045013143 D-loop; other site 653045013144 H-loop/switch region; other site 653045013145 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 653045013146 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045013147 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045013148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045013149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045013150 active site 653045013151 catalytic tetrad [active] 653045013152 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 653045013153 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 653045013154 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 653045013155 putative sugar binding sites [chemical binding]; other site 653045013156 Q-X-W motif; other site 653045013157 Methyltransferase domain; Region: Methyltransf_31; pfam13847 653045013158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045013159 S-adenosylmethionine binding site [chemical binding]; other site 653045013160 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 653045013161 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045013162 SGNH_hydrolase subfamily, similar to Ruminococcus flavefaciens XynB. Most likely a secreted hydrolase with xylanase activity. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from...; Region: XynB_like; cd01833 653045013163 active site 653045013164 catalytic triad [active] 653045013165 oxyanion hole [active] 653045013166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045013167 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 653045013168 Coenzyme A binding pocket [chemical binding]; other site 653045013169 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045013170 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 653045013171 tetrameric interface [polypeptide binding]; other site 653045013172 NAD binding site [chemical binding]; other site 653045013173 catalytic residues [active] 653045013174 substrate binding site [chemical binding]; other site 653045013175 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045013176 Putative cyclase; Region: Cyclase; cl00814 653045013177 Sodium:solute symporter family; Region: SSF; cl00456 653045013178 Arginase family; Region: Arginase; cl00306 653045013179 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 653045013180 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 653045013181 Helix-turn-helix domains; Region: HTH; cl00088 653045013182 Probable transposase; Region: OrfB_IS605; pfam01385 653045013183 hypothetical protein; Provisional; Region: PRK08317 653045013184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045013185 S-adenosylmethionine binding site [chemical binding]; other site 653045013186 Predicted acyl esterases [General function prediction only]; Region: COG2936 653045013187 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 653045013188 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045013189 Predicted transcriptional regulator [Transcription]; Region: COG1959 653045013190 Helix-turn-helix domains; Region: HTH; cl00088 653045013191 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 653045013192 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045013193 active site 653045013194 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045013195 classical (c) SDRs; Region: SDR_c; cd05233 653045013196 NAD(P) binding site [chemical binding]; other site 653045013197 active site 653045013198 classical (c) SDRs; Region: SDR_c; cd05233 653045013199 NAD(P) binding site [chemical binding]; other site 653045013200 active site 653045013201 Dehydratase family; Region: ILVD_EDD; cl00340 653045013202 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045013203 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045013204 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 653045013205 Predicted permease; Region: DUF318; pfam03773 653045013206 Predicted permeases [General function prediction only]; Region: COG0701 653045013207 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045013208 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013209 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045013210 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045013211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045013212 DNA binding site [nucleotide binding] 653045013213 domain linker motif; other site 653045013214 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045013215 dimerization interface [polypeptide binding]; other site 653045013216 ligand binding site [chemical binding]; other site 653045013217 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 653045013218 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 653045013219 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 653045013220 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 653045013221 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045013222 Histidine kinase; Region: HisKA_3; pfam07730 653045013223 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045013224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045013225 active site 653045013226 phosphorylation site [posttranslational modification] 653045013227 intermolecular recognition site; other site 653045013228 dimerization interface [polypeptide binding]; other site 653045013229 Helix-turn-helix domains; Region: HTH; cl00088 653045013230 dimerization interface [polypeptide binding]; other site 653045013231 DNA binding residues [nucleotide binding] 653045013232 Helix-turn-helix domains; Region: HTH; cl00088 653045013233 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045013234 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 653045013235 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045013236 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 653045013237 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013238 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 653045013239 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 653045013240 active site 653045013241 substrate binding site [chemical binding]; other site 653045013242 FMN binding site [chemical binding]; other site 653045013243 putative catalytic residues [active] 653045013244 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045013245 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 653045013246 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 653045013247 acyl-CoA synthetase; Validated; Region: PRK06188 653045013248 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013249 Golgi phosphoprotein 3 (GPP34); Region: GPP34; pfam05719 653045013250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045013251 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045013252 DNA binding residues [nucleotide binding] 653045013253 dimerization interface [polypeptide binding]; other site 653045013254 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045013255 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045013256 putative NAD(P) binding site [chemical binding]; other site 653045013257 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 653045013258 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 653045013259 substrate binding pocket [chemical binding]; other site 653045013260 catalytic residues [active] 653045013261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045013262 Helix-turn-helix domains; Region: HTH; cl00088 653045013263 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 653045013264 benzoate transport; Region: 2A0115; TIGR00895 653045013265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045013266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045013267 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 653045013268 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 653045013269 tetramer interface [polypeptide binding]; other site 653045013270 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 653045013271 tetramer interface [polypeptide binding]; other site 653045013272 active site 653045013273 metal binding site [ion binding]; metal-binding site 653045013274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2828 653045013275 probable AcnD-accessory protein PrpF; Region: prpF; TIGR02334 653045013276 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 653045013277 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045013278 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045013279 DNA-binding site [nucleotide binding]; DNA binding site 653045013280 FCD domain; Region: FCD; cl11656 653045013281 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl03513 653045013282 substrate binding site [chemical binding]; other site 653045013283 catalytic residues [active] 653045013284 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 653045013285 Spore germination protein; Region: Spore_permease; cl15802 653045013286 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 653045013287 NodB motif; other site 653045013288 active site 653045013289 catalytic site [active] 653045013290 metal binding site [ion binding]; metal-binding site 653045013291 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045013292 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 653045013293 Necrosis inducing protein (NPP1); Region: NPP1; pfam05630 653045013294 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045013295 Helix-turn-helix domains; Region: HTH; cl00088 653045013296 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045013297 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045013298 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045013299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045013300 dimer interface [polypeptide binding]; other site 653045013301 conserved gate region; other site 653045013302 putative PBP binding loops; other site 653045013303 ABC-ATPase subunit interface; other site 653045013304 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 653045013305 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045013306 Walker A/P-loop; other site 653045013307 ATP binding site [chemical binding]; other site 653045013308 Q-loop/lid; other site 653045013309 ABC transporter signature motif; other site 653045013310 Walker B; other site 653045013311 D-loop; other site 653045013312 H-loop/switch region; other site 653045013313 NMT1-like family; Region: NMT1_2; cl15260 653045013314 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 653045013315 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 653045013316 Sulfatase; Region: Sulfatase; cl10460 653045013317 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 653045013318 putative substrate binding site [chemical binding]; other site 653045013319 active site 653045013320 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045013321 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045013322 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045013323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045013324 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 653045013325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045013326 putative PBP binding loops; other site 653045013327 dimer interface [polypeptide binding]; other site 653045013328 ABC-ATPase subunit interface; other site 653045013329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045013330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045013331 dimer interface [polypeptide binding]; other site 653045013332 conserved gate region; other site 653045013333 ABC-ATPase subunit interface; other site 653045013334 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045013335 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045013336 DNA binding site [nucleotide binding] 653045013337 domain linker motif; other site 653045013338 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045013339 dimerization interface [polypeptide binding]; other site 653045013340 ligand binding site [chemical binding]; other site 653045013341 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013342 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013343 acyl-CoA synthetase; Validated; Region: PRK08308 653045013344 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013345 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 653045013346 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045013347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045013348 homodimer interface [polypeptide binding]; other site 653045013349 catalytic residue [active] 653045013350 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045013351 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 653045013352 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045013353 S-adenosylmethionine binding site [chemical binding]; other site 653045013354 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045013355 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013356 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045013357 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 653045013358 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045013359 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045013360 DNA binding site [nucleotide binding] 653045013361 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045013362 ligand binding site [chemical binding]; other site 653045013363 dimerization interface [polypeptide binding]; other site 653045013364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013366 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045013367 Helix-turn-helix domains; Region: HTH; cl00088 653045013368 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 653045013369 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 653045013370 potential catalytic triad [active] 653045013371 conserved cys residue [active] 653045013372 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045013373 Helix-turn-helix domains; Region: HTH; cl00088 653045013374 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045013375 dimerization interface [polypeptide binding]; other site 653045013376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045013377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045013378 active site 653045013379 phosphorylation site [posttranslational modification] 653045013380 intermolecular recognition site; other site 653045013381 dimerization interface [polypeptide binding]; other site 653045013382 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045013383 dimerization interface [polypeptide binding]; other site 653045013384 DNA binding residues [nucleotide binding] 653045013385 Histidine kinase; Region: HisKA_3; pfam07730 653045013386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045013387 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045013388 FtsX-like permease family; Region: FtsX; cl15850 653045013389 FtsX-like permease family; Region: FtsX; cl15850 653045013390 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045013391 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045013392 active site 653045013393 ATP binding site [chemical binding]; other site 653045013394 substrate binding site [chemical binding]; other site 653045013395 activation loop (A-loop); other site 653045013396 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 653045013397 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 653045013398 glycoside hydrolase family 64 (beta-1,3-glucanases which produce specific pentasaccharide oligomers) and thaumatin-like proteins; Region: GH64-TLP-SF; cl02511 653045013399 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 653045013400 Zn2+ binding site [ion binding]; other site 653045013401 Mg2+ binding site [ion binding]; other site 653045013402 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 653045013403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: GguC; COG3802 653045013404 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045013405 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045013406 substrate binding pocket [chemical binding]; other site 653045013407 chain length determination region; other site 653045013408 substrate-Mg2+ binding site; other site 653045013409 catalytic residues [active] 653045013410 aspartate-rich region 1; other site 653045013411 active site lid residues [active] 653045013412 geranyl diphosphate synthase; Region: PLN02890 653045013413 aspartate-rich region 2; other site 653045013414 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045013415 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045013416 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 653045013417 TPR repeat; Region: TPR_11; pfam13414 653045013418 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 653045013419 Domain of unknown function (DUF1338); Region: DUF1338; cl02226 653045013420 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 653045013421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045013422 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 653045013423 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045013424 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045013425 Helix-turn-helix domains; Region: HTH; cl00088 653045013426 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045013427 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 653045013428 trimer interface [polypeptide binding]; other site 653045013429 putative substrate binding pocket [chemical binding]; other site 653045013430 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 653045013431 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 653045013432 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 653045013433 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 653045013434 active site 653045013435 DNA binding site [nucleotide binding] 653045013436 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 653045013437 DNA binding site [nucleotide binding] 653045013438 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045013439 Predicted ATPase [General function prediction only]; Region: COG3899 653045013440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013441 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 653045013442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045013443 DNA binding residues [nucleotide binding] 653045013444 dimerization interface [polypeptide binding]; other site 653045013445 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045013446 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045013447 substrate binding pocket [chemical binding]; other site 653045013448 catalytic triad [active] 653045013449 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 653045013450 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 653045013451 CHAT domain; Region: CHAT; pfam12770 653045013452 RES domain; Region: RES; cl02411 653045013453 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045013454 phosphopeptide binding site; other site 653045013455 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045013457 Walker A motif; other site 653045013458 Walker A motif; other site 653045013459 ATP binding site [chemical binding]; other site 653045013460 Walker B motif; other site 653045013461 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 653045013462 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045013463 active site 653045013464 substrate binding site [chemical binding]; other site 653045013465 activation loop (A-loop); other site 653045013466 UbiA prenyltransferase family; Region: UbiA; cl00337 653045013467 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 653045013468 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 653045013469 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 653045013470 dimer interface [polypeptide binding]; other site 653045013471 active site 653045013472 metal binding site [ion binding]; metal-binding site 653045013473 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045013474 N-acetylmannosamine kinase; Provisional; Region: PRK05082 653045013475 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 653045013476 trimer interface [polypeptide binding]; other site 653045013477 active site 653045013478 dimer interface [polypeptide binding]; other site 653045013479 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 653045013480 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 653045013481 inhibitor-cofactor binding pocket; inhibition site 653045013482 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045013483 catalytic residue [active] 653045013484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045013485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013486 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045013487 3-amino-5-hydroxybenoic acid synthesis related protein; Region: AHBA_synth_RP; TIGR01454 653045013488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045013489 motif II; other site 653045013490 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045013491 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045013492 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045013493 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 653045013494 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 653045013495 PepSY-associated TM helix; Region: PepSY_TM_2; cl15813 653045013496 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 653045013497 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045013498 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 653045013499 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 653045013500 GAF domain; Region: GAF; cl15785 653045013501 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045013502 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045013503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013504 Walker A motif; other site 653045013505 ATP binding site [chemical binding]; other site 653045013506 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 653045013507 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 653045013508 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 653045013509 DNA binding site [nucleotide binding] 653045013510 active site 653045013511 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 653045013512 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 653045013513 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045013514 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 653045013515 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045013516 N-acetyltransferase; Region: Acetyltransf_2; cl00949 653045013517 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013518 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013519 active site 653045013520 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013521 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013522 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013523 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013524 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013525 active site 653045013526 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013527 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013528 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013529 putative NADP binding site [chemical binding]; other site 653045013530 active site 653045013531 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013532 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013533 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013535 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045013536 Enoylreductase; Region: PKS_ER; smart00829 653045013537 NAD(P) binding site [chemical binding]; other site 653045013538 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013539 putative NADP binding site [chemical binding]; other site 653045013540 active site 653045013541 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013542 Erythronolide synthase docking; Region: Docking; pfam08990 653045013543 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013544 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013545 active site 653045013546 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013547 Erythronolide synthase docking; Region: Docking; pfam08990 653045013548 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013549 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013550 active site 653045013551 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013552 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013553 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013554 putative NADP binding site [chemical binding]; other site 653045013555 active site 653045013556 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013557 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013558 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013559 active site 653045013560 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013561 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013562 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013563 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045013564 Enoylreductase; Region: PKS_ER; smart00829 653045013565 NAD(P) binding site [chemical binding]; other site 653045013566 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013567 putative NADP binding site [chemical binding]; other site 653045013568 active site 653045013569 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013570 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 653045013571 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013572 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013573 putative NADP binding site [chemical binding]; other site 653045013574 active site 653045013575 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013576 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013577 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013578 active site 653045013579 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013580 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013581 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013582 putative NADP binding site [chemical binding]; other site 653045013583 active site 653045013584 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013585 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013586 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013587 active site 653045013588 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013589 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013590 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013591 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013592 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013593 active site 653045013594 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013595 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013596 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013597 NADP binding site [chemical binding]; other site 653045013598 active site 653045013599 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013600 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 653045013601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013602 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045013603 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045013604 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045013605 DNA binding residues [nucleotide binding] 653045013606 dimerization interface [polypeptide binding]; other site 653045013607 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 653045013608 putative FMN binding site [chemical binding]; other site 653045013609 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045013610 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045013611 NAD(P) binding site [chemical binding]; other site 653045013612 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 653045013613 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 653045013614 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 653045013615 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045013616 Helix-turn-helix domains; Region: HTH; cl00088 653045013617 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 653045013618 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 653045013619 putative Iron-sulfur protein interface [polypeptide binding]; other site 653045013620 proximal heme binding site [chemical binding]; other site 653045013621 distal heme binding site [chemical binding]; other site 653045013622 putative dimer interface [polypeptide binding]; other site 653045013623 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 653045013624 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013625 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 653045013626 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 653045013627 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045013628 4Fe-4S binding domain; Region: Fer4; cl02805 653045013629 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_2; cd08895 653045013630 putative hydrophobic ligand binding site [chemical binding]; other site 653045013631 Helix-turn-helix domains; Region: HTH; cl00088 653045013632 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045013633 FAD binding domain; Region: FAD_binding_3; pfam01494 653045013634 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013635 Pectate lyase; Region: Pec_lyase_C; cl01593 653045013636 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 653045013637 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 653045013638 active site 653045013639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045013640 S-adenosylmethionine binding site [chemical binding]; other site 653045013641 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 653045013642 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 653045013643 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 653045013644 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 653045013645 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 653045013646 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 653045013647 active site 653045013648 NTP binding site [chemical binding]; other site 653045013649 metal binding triad [ion binding]; metal-binding site 653045013650 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045013651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045013652 active site 653045013653 phosphorylation site [posttranslational modification] 653045013654 intermolecular recognition site; other site 653045013655 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045013656 DNA binding residues [nucleotide binding] 653045013657 dimerization interface [polypeptide binding]; other site 653045013658 Histidine kinase; Region: HisKA_3; pfam07730 653045013659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045013660 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 653045013661 EamA-like transporter family; Region: EamA; cl01037 653045013662 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045013663 Helix-turn-helix domains; Region: HTH; cl00088 653045013664 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045013665 dimerization interface [polypeptide binding]; other site 653045013666 substrate binding pocket [chemical binding]; other site 653045013667 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 653045013668 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 653045013669 SpaB C-terminal domain; Region: SpaB_C; cl14828 653045013670 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 653045013671 active site 653045013672 zinc binding site [ion binding]; other site 653045013673 Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606 653045013674 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045013675 Erythronolide synthase docking; Region: Docking; pfam08990 653045013676 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013677 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013678 active site 653045013679 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013680 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013681 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013682 NADP binding site [chemical binding]; other site 653045013683 active site 653045013684 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013685 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013686 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013687 active site 653045013688 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013689 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013690 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013691 NADP binding site [chemical binding]; other site 653045013692 active site 653045013693 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013694 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013695 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013696 active site 653045013697 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013698 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013699 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013700 NADP binding site [chemical binding]; other site 653045013701 active site 653045013702 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013703 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013704 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013705 active site 653045013706 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013707 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013708 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013709 NADP binding site [chemical binding]; other site 653045013710 active site 653045013711 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013712 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013713 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013714 active site 653045013715 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013716 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013717 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013718 NADP binding site [chemical binding]; other site 653045013719 active site 653045013720 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013721 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013723 active site 653045013724 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013725 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013726 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013727 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045013728 Enoylreductase; Region: PKS_ER; smart00829 653045013729 NAD(P) binding site [chemical binding]; other site 653045013730 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013731 putative NADP binding site [chemical binding]; other site 653045013732 active site 653045013733 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013734 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013735 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013736 active site 653045013737 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013738 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013739 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013740 putative NADP binding site [chemical binding]; other site 653045013741 active site 653045013742 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013743 Erythronolide synthase docking; Region: Docking; pfam08990 653045013744 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013745 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013746 active site 653045013747 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013748 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013749 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013750 putative NADP binding site [chemical binding]; other site 653045013751 active site 653045013752 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013753 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013754 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013755 active site 653045013756 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013757 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013758 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013759 NADP binding site [chemical binding]; other site 653045013760 active site 653045013761 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013762 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013763 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013764 active site 653045013765 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013766 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013767 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013768 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045013769 Enoylreductase; Region: PKS_ER; smart00829 653045013770 NAD(P) binding site [chemical binding]; other site 653045013771 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013772 putative NADP binding site [chemical binding]; other site 653045013773 active site 653045013774 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013775 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013776 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013777 active site 653045013778 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013779 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013780 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013781 putative NADP binding site [chemical binding]; other site 653045013782 active site 653045013783 acyl-CoA synthetase; Validated; Region: PRK06060 653045013784 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013785 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013786 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013787 active site 653045013788 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013789 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013790 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013791 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013792 active site 653045013793 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013794 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013795 NADP binding site [chemical binding]; other site 653045013796 active site 653045013797 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013798 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045013799 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013800 active site 653045013801 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013802 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045013803 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045013804 putative NADP binding site [chemical binding]; other site 653045013805 active site 653045013806 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013807 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045013808 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045013809 active site 653045013810 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045013811 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045013812 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045013813 NADP binding site [chemical binding]; other site 653045013814 active site 653045013815 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013816 peptide synthase; Provisional; Region: PRK12467 653045013817 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013818 AMP-binding enzyme; Region: AMP-binding; cl15778 653045013819 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045013820 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045013821 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045013822 Helix-turn-helix domains; Region: HTH; cl00088 653045013823 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045013824 dimerization interface [polypeptide binding]; other site 653045013825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045013826 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045013827 Helix-turn-helix domains; Region: HTH; cl00088 653045013828 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045013829 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045013830 DNA binding site [nucleotide binding] 653045013831 domain linker motif; other site 653045013832 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 653045013833 putative dimerization interface [polypeptide binding]; other site 653045013834 putative ligand binding site [chemical binding]; other site 653045013835 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045013836 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 653045013837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045013838 dimer interface [polypeptide binding]; other site 653045013839 conserved gate region; other site 653045013840 putative PBP binding loops; other site 653045013841 ABC-ATPase subunit interface; other site 653045013842 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045013843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045013844 dimer interface [polypeptide binding]; other site 653045013845 conserved gate region; other site 653045013846 putative PBP binding loops; other site 653045013847 ABC-ATPase subunit interface; other site 653045013848 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 653045013849 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 653045013850 active site 653045013851 catalytic site [active] 653045013852 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 653045013853 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 653045013854 putative metal binding site [ion binding]; other site 653045013855 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 653045013856 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045013857 sugar binding site [chemical binding]; other site 653045013858 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 653045013859 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 653045013860 Ligand Binding Site [chemical binding]; other site 653045013861 Glycosyl hydrolase family 62, characterized arabinofuranosidases; Region: GH62; cd08987 653045013862 active site 653045013863 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 653045013864 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 653045013865 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 653045013866 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045013867 metal binding site [ion binding]; metal-binding site 653045013868 substrate binding pocket [chemical binding]; other site 653045013869 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 653045013870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045013871 putative substrate translocation pore; other site 653045013872 NIPSNAP; Region: NIPSNAP; pfam07978 653045013873 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045013874 putative NAD(P) binding site [chemical binding]; other site 653045013875 Helix-turn-helix domains; Region: HTH; cl00088 653045013876 YceI-like domain; Region: YceI; cl01001 653045013877 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 653045013878 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045013879 Uncharacterized conserved protein [Function unknown]; Region: COG3777 653045013880 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045013881 active site 2 [active] 653045013882 active site 1 [active] 653045013883 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 653045013884 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045013885 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 653045013886 Helix-turn-helix domains; Region: HTH; cl00088 653045013887 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 653045013888 putative dimerization interface [polypeptide binding]; other site 653045013889 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045013890 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045013891 active site 653045013892 FAD binding domain; Region: FAD_binding_4; pfam01565 653045013893 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 653045013894 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 653045013895 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045013896 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045013897 Helix-turn-helix domains; Region: HTH; cl00088 653045013898 Histidine kinase; Region: HisKA_3; pfam07730 653045013899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045013900 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045013901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045013902 active site 653045013903 phosphorylation site [posttranslational modification] 653045013904 intermolecular recognition site; other site 653045013905 dimerization interface [polypeptide binding]; other site 653045013906 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045013907 dimerization interface [polypeptide binding]; other site 653045013908 DNA binding residues [nucleotide binding] 653045013909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045013910 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045013911 FtsX-like permease family; Region: FtsX; cl15850 653045013912 FtsX-like permease family; Region: FtsX; cl15850 653045013913 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045013914 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045013915 Walker A/P-loop; other site 653045013916 ATP binding site [chemical binding]; other site 653045013917 Q-loop/lid; other site 653045013918 ABC transporter signature motif; other site 653045013919 Walker B; other site 653045013920 D-loop; other site 653045013921 H-loop/switch region; other site 653045013922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045013923 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045013924 active site 653045013925 phosphorylation site [posttranslational modification] 653045013926 intermolecular recognition site; other site 653045013927 dimerization interface [polypeptide binding]; other site 653045013928 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045013929 DNA binding residues [nucleotide binding] 653045013930 dimerization interface [polypeptide binding]; other site 653045013931 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045013932 Histidine kinase; Region: HisKA_3; pfam07730 653045013933 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045013934 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045013935 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 653045013936 active site 1 [active] 653045013937 dimer interface [polypeptide binding]; other site 653045013938 hexamer interface [polypeptide binding]; other site 653045013939 active site 2 [active] 653045013940 short chain dehydrogenase; Provisional; Region: PRK12937 653045013941 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013942 NAD(P) binding site [chemical binding]; other site 653045013943 active site 653045013944 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045013945 salt bridge; other site 653045013946 non-specific DNA binding site [nucleotide binding]; other site 653045013947 sequence-specific DNA binding site [nucleotide binding]; other site 653045013948 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045013949 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045013950 active site 653045013951 catalytic tetrad [active] 653045013952 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013953 NAD(P) binding site [chemical binding]; other site 653045013954 active site 653045013955 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 653045013956 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045013957 Helix-turn-helix domains; Region: HTH; cl00088 653045013958 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045013959 classical (c) SDRs; Region: SDR_c; cd05233 653045013960 NAD(P) binding site [chemical binding]; other site 653045013961 active site 653045013962 Alpha-L-arabinofuranosidase B, catalytic; Region: ArabFuran-catal; pfam09206 653045013963 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 653045013964 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 653045013965 active site 653045013966 catalytic site [active] 653045013967 substrate binding site [chemical binding]; other site 653045013968 Dienelactone hydrolase family; Region: DLH; pfam01738 653045013969 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045013970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045013971 Helix-turn-helix domains; Region: HTH; cl00088 653045013972 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045013973 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045013974 Helix-turn-helix domains; Region: HTH; cl00088 653045013975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045013976 dimerization interface [polypeptide binding]; other site 653045013977 Predicted transcriptional regulator [Transcription]; Region: COG1959 653045013978 Helix-turn-helix domains; Region: HTH; cl00088 653045013979 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 653045013980 putative active site [active] 653045013981 putative FMN binding site [chemical binding]; other site 653045013982 putative substrate binding site [chemical binding]; other site 653045013983 putative catalytic residue [active] 653045013984 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 653045013985 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045013986 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 653045013987 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045013988 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045013989 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 653045013990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045013991 NAD(P) binding site [chemical binding]; other site 653045013992 active site 653045013993 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 653045013994 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045013995 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045013996 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 653045013997 active site 653045013998 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045013999 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 653045014000 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 653045014001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045014002 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014003 NAD(P) binding site [chemical binding]; other site 653045014004 active site 653045014005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014006 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045014007 putative substrate translocation pore; other site 653045014008 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014009 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045014010 active site 653045014011 TDP-binding site; other site 653045014012 acceptor substrate-binding pocket; other site 653045014013 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 653045014014 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 653045014015 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014016 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045014017 Helix-turn-helix domains; Region: HTH; cl00088 653045014018 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 653045014019 amidase catalytic site [active] 653045014020 Zn binding residues [ion binding]; other site 653045014021 substrate binding site [chemical binding]; other site 653045014022 Baseplate J-like protein; Region: Baseplate_J; cl01294 653045014023 Baseplate J-like protein; Region: Baseplate_J; cl01294 653045014024 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 653045014025 Baseplate J-like protein; Region: Baseplate_J; cl01294 653045014026 Baseplate J-like protein; Region: Baseplate_J; cl01294 653045014027 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 653045014028 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 653045014029 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 653045014030 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 653045014031 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 653045014032 Phage-related protein [Function unknown]; Region: COG5412 653045014033 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045014034 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014035 Protein of unknown function (DUF4255); Region: DUF4255; pfam14065 653045014036 T4-like virus tail tube protein gp19; Region: Phage_T4_gp19; cl12125 653045014037 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 653045014038 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 653045014039 Probable transposase; Region: OrfB_IS605; pfam01385 653045014040 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 653045014041 Transposase IS200 like; Region: Y1_Tnp; cl00848 653045014042 SpoOM protein; Region: Spo0M; pfam07070 653045014043 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 653045014044 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045014045 hypothetical protein; Provisional; Region: PRK08317 653045014046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045014047 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045014048 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045014049 DNA binding residues [nucleotide binding] 653045014050 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045014051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 653045014052 active site 653045014053 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 653045014054 Spore germination protein; Region: Spore_permease; cl15802 653045014055 amino acid transporter; Region: 2A0306; TIGR00909 653045014056 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045014057 dimerization interface [polypeptide binding]; other site 653045014058 putative DNA binding site [nucleotide binding]; other site 653045014059 putative Zn2+ binding site [ion binding]; other site 653045014060 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 653045014061 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 653045014062 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045014063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045014064 dimerization interface [polypeptide binding]; other site 653045014065 putative DNA binding site [nucleotide binding]; other site 653045014066 putative Zn2+ binding site [ion binding]; other site 653045014067 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 653045014068 Cation efflux family; Region: Cation_efflux; cl00316 653045014069 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045014070 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045014071 DNA binding site [nucleotide binding] 653045014072 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045014073 ligand binding site [chemical binding]; other site 653045014074 dimerization interface [polypeptide binding]; other site 653045014075 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 653045014076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014077 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 653045014078 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045014079 metal binding site [ion binding]; metal-binding site 653045014080 substrate binding pocket [chemical binding]; other site 653045014081 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 653045014082 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 653045014083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014084 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045014085 putative substrate translocation pore; other site 653045014086 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 653045014087 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 653045014088 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 653045014089 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045014090 substrate binding site [chemical binding]; other site 653045014091 oxyanion hole (OAH) forming residues; other site 653045014092 trimer interface [polypeptide binding]; other site 653045014093 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 653045014094 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045014095 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045014096 active site 653045014097 metal binding site [ion binding]; metal-binding site 653045014098 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045014099 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045014100 anti sigma factor interaction site; other site 653045014101 regulatory phosphorylation site [posttranslational modification]; other site 653045014102 ANTAR domain; Region: ANTAR; cl04297 653045014103 GAF domain; Region: GAF_2; pfam13185 653045014104 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014105 FAD dependent oxidoreductase; Region: DAO; pfam01266 653045014106 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 653045014107 [2Fe-2S] cluster binding site [ion binding]; other site 653045014108 Protein of unknown function (DUF1396); Region: DUF1396; pfam07161 653045014109 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045014110 putative active site [active] 653045014111 heme pocket [chemical binding]; other site 653045014112 PAS fold; Region: PAS_4; pfam08448 653045014113 GAF domain; Region: GAF; cl15785 653045014114 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045014115 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045014116 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045014117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045014118 GAF domain; Region: GAF; cl15785 653045014119 Helix-turn-helix domains; Region: HTH; cl00088 653045014120 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 653045014121 Aspartase; Region: Aspartase; cd01357 653045014122 active sites [active] 653045014123 tetramer interface [polypeptide binding]; other site 653045014124 L-asparaginase II; Region: Asparaginase_II; cl01842 653045014125 L-asparagine permease; Provisional; Region: PRK15049 653045014126 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045014127 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045014128 DNA-binding site [nucleotide binding]; DNA binding site 653045014129 FCD domain; Region: FCD; cl11656 653045014130 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 653045014131 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 653045014132 ligand binding site [chemical binding]; other site 653045014133 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045014134 PAS domain; Region: PAS_9; pfam13426 653045014135 PAS fold; Region: PAS_4; pfam08448 653045014136 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045014137 putative active site [active] 653045014138 heme pocket [chemical binding]; other site 653045014139 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045014140 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045014141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045014142 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 653045014143 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 653045014144 putative active site [active] 653045014145 catalytic triad [active] 653045014146 putative dimer interface [polypeptide binding]; other site 653045014147 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045014148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014149 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 653045014150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014152 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045014153 DinB superfamily; Region: DinB_2; pfam12867 653045014154 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 653045014155 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 653045014156 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 653045014157 NHLP leader peptide domain; Region: TOMM_pelo; cl15464 653045014158 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 653045014159 nitrile hydratase, beta subunit; Region: nitrile_beta; cl03486 653045014160 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045014161 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045014162 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 653045014163 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045014164 Predicted transcriptional regulator [Transcription]; Region: COG2378 653045014165 Helix-turn-helix domains; Region: HTH; cl00088 653045014166 WYL domain; Region: WYL; cl14852 653045014167 Protein of unknown function (DUF3224); Region: DUF3224; pfam11528 653045014168 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 653045014169 ligand binding site [chemical binding]; other site 653045014170 active site 653045014171 UGI interface [polypeptide binding]; other site 653045014172 catalytic site [active] 653045014173 short chain dehydrogenase; Provisional; Region: PRK07856 653045014174 classical (c) SDRs; Region: SDR_c; cd05233 653045014175 NAD(P) binding site [chemical binding]; other site 653045014176 active site 653045014177 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 653045014178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014179 NAD(P) binding site [chemical binding]; other site 653045014180 active site 653045014181 Protein of unknown function (DUF3037); Region: DUF3037; pfam11236 653045014182 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 653045014183 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045014184 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 653045014185 Phosphotransferase enzyme family; Region: APH; pfam01636 653045014186 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 653045014187 substrate binding site [chemical binding]; other site 653045014188 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045014189 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 653045014190 hypothetical protein; Provisional; Region: PRK06185 653045014191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014192 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045014194 Helix-turn-helix domains; Region: HTH; cl00088 653045014195 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 653045014196 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 653045014197 putative active site [active] 653045014198 putative metal binding site [ion binding]; other site 653045014199 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 653045014200 Helix-turn-helix domains; Region: HTH; cl00088 653045014201 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 653045014202 Bacterial sugar transferase; Region: Bac_transf; cl00939 653045014203 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 653045014204 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 653045014205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014206 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 653045014207 Chain length determinant protein; Region: Wzz; cl15801 653045014208 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 653045014209 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 653045014210 active site 653045014211 dimer interface [polypeptide binding]; other site 653045014212 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 653045014213 Ligand Binding Site [chemical binding]; other site 653045014214 Molecular Tunnel; other site 653045014215 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045014216 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 653045014217 putative NAD(P) binding site [chemical binding]; other site 653045014218 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045014219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014220 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 653045014221 Right handed beta helix region; Region: Beta_helix; pfam13229 653045014222 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045014223 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 653045014224 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 653045014225 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045014226 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 653045014227 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045014228 active site 653045014229 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 653045014230 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045014231 extended (e) SDRs; Region: SDR_e; cd08946 653045014232 NAD(P) binding site [chemical binding]; other site 653045014233 active site 653045014234 substrate binding site [chemical binding]; other site 653045014235 M28 Zn-Peptidases; Region: M28_like_3; cd05644 653045014236 Domain of unknown function (DUF2172); Region: DUF2172; pfam09940 653045014237 active site 653045014238 metal binding site [ion binding]; metal-binding site 653045014239 MatE; Region: MatE; cl10513 653045014240 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045014241 active site 653045014242 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 653045014243 Cupin domain; Region: Cupin_2; cl09118 653045014244 glutamate-1-semialdehyde 2,1-aminomutase; Provisional; Region: PRK06209 653045014245 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045014246 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045014247 catalytic residue [active] 653045014248 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 653045014249 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045014250 Helix-turn-helix domains; Region: HTH; cl00088 653045014251 HutD; Region: HutD; cl01532 653045014252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014253 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 653045014254 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 653045014255 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045014256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045014257 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045014258 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045014259 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045014260 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 653045014261 Ligand Binding Site [chemical binding]; other site 653045014262 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 653045014263 Ligand Binding Site [chemical binding]; other site 653045014264 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045014265 Helix-turn-helix domains; Region: HTH; cl00088 653045014266 The C-terminal substrate-binding domain of putative LysR-type transcriptional regulator PAO1-like, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_PAO1_like; cd08412 653045014267 putative substrate binding pocket [chemical binding]; other site 653045014268 dimerization interface [polypeptide binding]; other site 653045014269 proline/glycine betaine transporter; Provisional; Region: PRK10642 653045014270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014271 putative substrate translocation pore; other site 653045014272 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 653045014273 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 653045014274 metal binding site [ion binding]; metal-binding site 653045014275 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 653045014276 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 653045014277 homotrimer interaction site [polypeptide binding]; other site 653045014278 putative active site [active] 653045014279 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 653045014280 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014281 Helix-turn-helix domains; Region: HTH; cl00088 653045014282 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045014283 ligand binding site [chemical binding]; other site 653045014284 flexible hinge region; other site 653045014285 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 653045014286 substrate binding pocket [chemical binding]; other site 653045014287 substrate-Mg2+ binding site; other site 653045014288 aspartate-rich region 1; other site 653045014289 active site lid residues [active] 653045014290 aspartate-rich region 2; other site 653045014291 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 653045014292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045014293 S-adenosylmethionine binding site [chemical binding]; other site 653045014294 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045014295 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 653045014296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014297 GAF domain; Region: GAF_2; pfam13185 653045014298 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045014299 putative active site [active] 653045014300 heme pocket [chemical binding]; other site 653045014301 GAF domain; Region: GAF_2; pfam13185 653045014302 GAF domain; Region: GAF; cl15785 653045014303 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045014304 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045014305 YCII-related domain; Region: YCII; cl00999 653045014306 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 653045014307 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045014308 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045014309 YCII-related domain; Region: YCII; cl00999 653045014310 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045014311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045014312 Helix-turn-helix domains; Region: HTH; cl00088 653045014313 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045014314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014315 NAD(P) binding site [chemical binding]; other site 653045014316 active site 653045014317 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045014318 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014319 putative substrate translocation pore; other site 653045014320 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045014321 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014322 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 653045014323 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014324 Walker A/P-loop; other site 653045014325 Walker A/P-loop; other site 653045014326 ATP binding site [chemical binding]; other site 653045014327 ATP binding site [chemical binding]; other site 653045014328 Q-loop/lid; other site 653045014329 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 653045014330 ABC transporter signature motif; other site 653045014331 Walker B; other site 653045014332 D-loop; other site 653045014333 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 653045014334 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 653045014335 iron-sulfur cluster [ion binding]; other site 653045014336 [2Fe-2S] cluster binding site [ion binding]; other site 653045014337 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 653045014338 catalytic triad [active] 653045014339 conserved cis-peptide bond; other site 653045014340 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045014341 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045014342 Helix-turn-helix domains; Region: HTH; cl00088 653045014343 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045014344 putative dimerization interface [polypeptide binding]; other site 653045014345 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 653045014346 EamA-like transporter family; Region: EamA; cl01037 653045014347 transcriptional regulatory protein PtsJ; Provisional; Region: PRK15481 653045014348 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045014349 DNA-binding site [nucleotide binding]; DNA binding site 653045014350 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045014351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045014352 homodimer interface [polypeptide binding]; other site 653045014353 catalytic residue [active] 653045014354 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045014355 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 653045014356 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045014357 hydrophobic ligand binding site; other site 653045014358 Helix-turn-helix domains; Region: HTH; cl00088 653045014359 Phenazine biosynthesis-like protein; Region: PhzC-PhzF; pfam02567 653045014360 CAAX protease self-immunity; Region: Abi; cl00558 653045014361 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 653045014362 glycine dehydrogenase; Provisional; Region: PRK05367 653045014363 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 653045014364 tetramer interface [polypeptide binding]; other site 653045014365 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045014366 catalytic residue [active] 653045014367 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 653045014368 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045014369 tetramer interface [polypeptide binding]; other site 653045014370 catalytic residue [active] 653045014371 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 653045014372 DNA polymerase IV; Provisional; Region: PRK03348 653045014373 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 653045014374 active site 653045014375 DNA binding site [nucleotide binding] 653045014376 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 653045014377 DNA binding residues [nucleotide binding] 653045014378 putative dimer interface [polypeptide binding]; other site 653045014379 Bifunctional nuclease; Region: DNase-RNase; cl00553 653045014380 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 653045014381 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045014382 DNA binding residues [nucleotide binding] 653045014383 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 653045014384 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045014385 phosphopeptide binding site; other site 653045014386 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 653045014387 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 653045014388 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 653045014389 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 653045014390 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 653045014391 active site 653045014392 Substrate binding site; other site 653045014393 Mg++ binding site; other site 653045014394 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 653045014395 putative trimer interface [polypeptide binding]; other site 653045014396 putative CoA binding site [chemical binding]; other site 653045014397 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 653045014398 GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity. The protein contains an...; Region: MPG1_transferase; cd05805 653045014399 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045014400 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 653045014401 HPr interaction site; other site 653045014402 glycerol kinase (GK) interaction site [polypeptide binding]; other site 653045014403 active site 653045014404 phosphorylation site [posttranslational modification] 653045014405 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 653045014406 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 653045014407 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 653045014408 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045014409 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 653045014410 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 653045014411 AMP-binding enzyme; Region: AMP-binding; cl15778 653045014412 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 653045014413 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 653045014414 trimer interface [polypeptide binding]; other site 653045014415 active site 653045014416 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 653045014417 catalytic site [active] 653045014418 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 653045014419 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 653045014420 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045014421 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 653045014422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045014423 dimer interface [polypeptide binding]; other site 653045014424 conserved gate region; other site 653045014425 putative PBP binding loops; other site 653045014426 ABC-ATPase subunit interface; other site 653045014427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045014428 putative PBP binding loops; other site 653045014429 dimer interface [polypeptide binding]; other site 653045014430 ABC-ATPase subunit interface; other site 653045014431 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 653045014432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045014433 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 653045014434 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014435 Walker A/P-loop; other site 653045014436 ATP binding site [chemical binding]; other site 653045014437 Q-loop/lid; other site 653045014438 ABC transporter signature motif; other site 653045014439 Walker B; other site 653045014440 D-loop; other site 653045014441 H-loop/switch region; other site 653045014442 TOBE domain; Region: TOBE_2; cl01440 653045014443 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 653045014444 lipid-transfer protein; Provisional; Region: PRK06059 653045014445 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 653045014446 active site 653045014447 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 653045014448 amphipathic channel; other site 653045014449 Asn-Pro-Ala signature motifs; other site 653045014450 glycerol kinase; Provisional; Region: glpK; PRK00047 653045014451 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 653045014452 N- and C-terminal domain interface [polypeptide binding]; other site 653045014453 putative active site [active] 653045014454 putative MgATP binding site [chemical binding]; other site 653045014455 catalytic site [active] 653045014456 metal binding site [ion binding]; metal-binding site 653045014457 putative homotetramer interface [polypeptide binding]; other site 653045014458 putative glycerol binding site [chemical binding]; other site 653045014459 homodimer interface [polypeptide binding]; other site 653045014460 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045014461 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 653045014462 G1 box; other site 653045014463 GTP/Mg2+ binding site [chemical binding]; other site 653045014464 G2 box; other site 653045014465 Switch I region; other site 653045014466 G3 box; other site 653045014467 Switch II region; other site 653045014468 G4 box; other site 653045014469 G5 box; other site 653045014470 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045014471 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045014472 Nitrate and nitrite sensing; Region: NIT; pfam08376 653045014473 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045014474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045014475 ATP binding site [chemical binding]; other site 653045014476 Mg2+ binding site [ion binding]; other site 653045014477 G-X-G motif; other site 653045014478 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 653045014479 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045014480 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 653045014481 [2Fe-2S] cluster binding site [ion binding]; other site 653045014482 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045014483 Helix-turn-helix domains; Region: HTH; cl00088 653045014484 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045014485 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 653045014486 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 653045014487 NAD binding site [chemical binding]; other site 653045014488 catalytic Zn binding site [ion binding]; other site 653045014489 substrate binding site [chemical binding]; other site 653045014490 structural Zn binding site [ion binding]; other site 653045014491 FAD dependent oxidoreductase; Region: DAO; pfam01266 653045014492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045014493 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 653045014494 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 653045014495 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 653045014496 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 653045014497 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 653045014498 [2Fe-2S] cluster binding site [ion binding]; other site 653045014499 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 653045014500 putative alpha subunit interface [polypeptide binding]; other site 653045014501 putative active site [active] 653045014502 putative substrate binding site [chemical binding]; other site 653045014503 Fe binding site [ion binding]; other site 653045014504 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 653045014505 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045014506 tetramerization interface [polypeptide binding]; other site 653045014507 NAD(P) binding site [chemical binding]; other site 653045014508 catalytic residues [active] 653045014509 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 653045014510 Protein of unknown function (DUF2891); Region: DUF2891; pfam11199 653045014511 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 653045014512 putative substrate binding pocket [chemical binding]; other site 653045014513 AC domain interface; other site 653045014514 catalytic triad [active] 653045014515 AB domain interface; other site 653045014516 interchain disulfide; other site 653045014517 Protein of unknown function (DUF979); Region: DUF979; cl01572 653045014518 Protein of unknown function (DUF969); Region: DUF969; cl01573 653045014519 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045014520 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045014521 DNA-binding site [nucleotide binding]; DNA binding site 653045014522 FCD domain; Region: FCD; cl11656 653045014523 LamB/YcsF family; Region: LamB_YcsF; cl00664 653045014524 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 653045014525 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 653045014526 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 653045014527 Transcription factor WhiB; Region: Whib; pfam02467 653045014528 5-oxoprolinase; Region: PLN02666 653045014529 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 653045014530 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 653045014531 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 653045014532 active site 653045014533 catalytic triad [active] 653045014534 oxyanion hole [active] 653045014535 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 653045014536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045014537 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 653045014538 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045014539 putative active site [active] 653045014540 heme pocket [chemical binding]; other site 653045014541 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045014542 Phosphotransferase enzyme family; Region: APH; pfam01636 653045014543 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045014544 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 653045014545 amidase catalytic site [active] 653045014546 Zn binding residues [ion binding]; other site 653045014547 substrate binding site [chemical binding]; other site 653045014548 Predicted ATPase [General function prediction only]; Region: COG3899 653045014549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014550 Helix-turn-helix domains; Region: HTH; cl00088 653045014551 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 653045014552 substrate binding pocket [chemical binding]; other site 653045014553 substrate-Mg2+ binding site; other site 653045014554 aspartate-rich region 1; other site 653045014555 aspartate-rich region 2; other site 653045014556 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 653045014557 AMP-binding enzyme; Region: AMP-binding; cl15778 653045014558 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045014559 acetyl-CoA acetyltransferase; Provisional; Region: PRK08313 653045014560 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 653045014561 active site 653045014562 lipid-transfer protein; Provisional; Region: PRK07937 653045014563 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045014564 active site 653045014565 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 653045014566 DUF35 OB-fold domain; Region: DUF35; pfam01796 653045014567 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 653045014568 DUF35 OB-fold domain; Region: DUF35; pfam01796 653045014569 enoyl-CoA hydratase; Provisional; Region: PRK07799 653045014570 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045014571 substrate binding site [chemical binding]; other site 653045014572 oxyanion hole (OAH) forming residues; other site 653045014573 trimer interface [polypeptide binding]; other site 653045014574 acyl-CoA synthetase; Validated; Region: PRK07798 653045014575 AMP-binding enzyme; Region: AMP-binding; cl15778 653045014576 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 653045014577 active site pocket [active] 653045014578 oxyanion hole [active] 653045014579 catalytic triad [active] 653045014580 active site nucleophile [active] 653045014581 Chorismate mutase type II; Region: CM_2; cl00693 653045014582 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08276 653045014583 AMP-binding enzyme; Region: AMP-binding; cl15778 653045014584 AMP-binding enzyme; Region: AMP-binding; cl15778 653045014585 Nitronate monooxygenase; Region: NMO; pfam03060 653045014586 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 653045014587 FMN binding site [chemical binding]; other site 653045014588 substrate binding site [chemical binding]; other site 653045014589 putative catalytic residue [active] 653045014590 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 653045014591 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014592 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045014593 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045014594 active site 653045014595 ATP binding site [chemical binding]; other site 653045014596 substrate binding site [chemical binding]; other site 653045014597 activation loop (A-loop); other site 653045014598 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045014599 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045014600 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045014601 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045014602 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 653045014603 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045014604 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 653045014605 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045014606 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045014607 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045014608 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 653045014609 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014610 Walker A/P-loop; other site 653045014611 ATP binding site [chemical binding]; other site 653045014612 Q-loop/lid; other site 653045014613 AAA domain; Region: AAA_21; pfam13304 653045014614 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 653045014615 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014616 Q-loop/lid; other site 653045014617 ABC transporter signature motif; other site 653045014618 Walker B; other site 653045014619 D-loop; other site 653045014620 H-loop/switch region; other site 653045014621 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045014622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045014623 dimer interface [polypeptide binding]; other site 653045014624 phosphorylation site [posttranslational modification] 653045014625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045014626 ATP binding site [chemical binding]; other site 653045014627 Mg2+ binding site [ion binding]; other site 653045014628 G-X-G motif; other site 653045014629 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045014630 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045014631 active site 653045014632 phosphorylation site [posttranslational modification] 653045014633 intermolecular recognition site; other site 653045014634 dimerization interface [polypeptide binding]; other site 653045014635 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045014636 DNA binding site [nucleotide binding] 653045014637 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 653045014638 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 653045014639 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 653045014640 FAD binding pocket [chemical binding]; other site 653045014641 FAD binding motif [chemical binding]; other site 653045014642 phosphate binding motif [ion binding]; other site 653045014643 beta-alpha-beta structure motif; other site 653045014644 NAD binding pocket [chemical binding]; other site 653045014645 FMN-binding domain; Region: FMN_bind; cl01081 653045014646 ApbE family; Region: ApbE; cl00643 653045014647 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045014648 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045014649 active site 653045014650 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045014651 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 653045014652 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 653045014653 DAK2 domain; Region: Dak2; cl03685 653045014654 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 653045014655 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045014656 substrate binding pocket [chemical binding]; other site 653045014657 chain length determination region; other site 653045014658 substrate-Mg2+ binding site; other site 653045014659 catalytic residues [active] 653045014660 aspartate-rich region 1; other site 653045014661 active site lid residues [active] 653045014662 aspartate-rich region 2; other site 653045014663 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 653045014664 substrate binding pocket [chemical binding]; other site 653045014665 substrate-Mg2+ binding site; other site 653045014666 aspartate-rich region 1; other site 653045014667 aspartate-rich region 2; other site 653045014668 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045014669 Cytochrome P450; Region: p450; pfam00067 653045014670 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045014671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045014672 Helix-turn-helix domains; Region: HTH; cl00088 653045014673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014674 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045014675 putative substrate translocation pore; other site 653045014676 GAF domain; Region: GAF_2; pfam13185 653045014677 GAF domain; Region: GAF; cl15785 653045014678 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 653045014679 Helix-turn-helix domains; Region: HTH; cl00088 653045014680 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014681 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 653045014682 NAD(P) binding site [chemical binding]; other site 653045014683 active site 653045014684 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 653045014685 nudix motif; other site 653045014686 O-Antigen ligase; Region: Wzy_C; cl04850 653045014687 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 653045014688 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 653045014689 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045014690 active site 653045014691 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045014692 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045014693 putative metal binding site [ion binding]; other site 653045014694 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 653045014695 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045014696 putative metal binding site [ion binding]; other site 653045014697 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045014698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045014699 active site 653045014700 dimerization interface [polypeptide binding]; other site 653045014701 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045014702 DNA binding residues [nucleotide binding] 653045014703 dimerization interface [polypeptide binding]; other site 653045014704 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045014705 ligand binding site [chemical binding]; other site 653045014706 flexible hinge region; other site 653045014707 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045014708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045014709 ATP binding site [chemical binding]; other site 653045014710 Mg2+ binding site [ion binding]; other site 653045014711 G-X-G motif; other site 653045014712 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 653045014713 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 653045014714 GAF domain; Region: GAF_2; pfam13185 653045014715 GAF domain; Region: GAF; cl15785 653045014716 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045014717 Histidine kinase; Region: HisKA_3; pfam07730 653045014718 Right handed beta helix region; Region: Beta_helix; pfam13229 653045014719 Right handed beta helix region; Region: Beta_helix; pfam13229 653045014720 stage V sporulation protein K; Region: spore_V_K; TIGR02881 653045014721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045014722 Walker A motif; other site 653045014723 ATP binding site [chemical binding]; other site 653045014724 Walker B motif; other site 653045014725 arginine finger; other site 653045014726 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045014727 Helix-turn-helix domains; Region: HTH; cl00088 653045014728 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045014729 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 653045014730 putative hydrophobic ligand binding site [chemical binding]; other site 653045014731 protein interface [polypeptide binding]; other site 653045014732 gate; other site 653045014733 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 653045014734 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 653045014735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045014736 catalytic residue [active] 653045014737 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045014738 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045014739 Short C-terminal domain; Region: SHOCT; cl01373 653045014740 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045014741 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045014742 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045014743 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045014744 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 653045014745 CoenzymeA binding site [chemical binding]; other site 653045014746 subunit interaction site [polypeptide binding]; other site 653045014747 PHB binding site; other site 653045014748 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 653045014749 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045014750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045014751 active site 653045014752 phosphorylation site [posttranslational modification] 653045014753 intermolecular recognition site; other site 653045014754 dimerization interface [polypeptide binding]; other site 653045014755 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045014756 dimerization interface [polypeptide binding]; other site 653045014757 DNA binding residues [nucleotide binding] 653045014758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045014759 Histidine kinase; Region: HisKA_3; pfam07730 653045014760 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 653045014761 hypothetical protein; Provisional; Region: PRK07907 653045014762 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 653045014763 active site 653045014764 metal binding site [ion binding]; metal-binding site 653045014765 dimer interface [polypeptide binding]; other site 653045014766 AAA domain; Region: AAA_33; pfam13671 653045014767 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014768 active site 653045014769 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 653045014770 nudix motif; other site 653045014771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045014772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045014773 dimer interface [polypeptide binding]; other site 653045014774 conserved gate region; other site 653045014775 putative PBP binding loops; other site 653045014776 ABC-ATPase subunit interface; other site 653045014777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045014778 dimer interface [polypeptide binding]; other site 653045014779 conserved gate region; other site 653045014780 putative PBP binding loops; other site 653045014781 ABC-ATPase subunit interface; other site 653045014782 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045014783 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045014784 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045014785 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 653045014786 NPCBM/NEW2 domain; Region: NPCBM; cl07060 653045014787 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045014788 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045014789 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045014790 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045014791 DNA binding site [nucleotide binding] 653045014792 domain linker motif; other site 653045014793 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045014794 ligand binding site [chemical binding]; other site 653045014795 dimerization interface [polypeptide binding]; other site 653045014796 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 653045014797 Short C-terminal domain; Region: SHOCT; cl01373 653045014798 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045014799 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 653045014800 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 653045014801 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 653045014802 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 653045014803 Ligand binding site [chemical binding]; other site 653045014804 Electron transfer flavoprotein domain; Region: ETF; pfam01012 653045014805 Flavin Reductases; Region: FlaRed; cl00801 653045014806 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 653045014807 catalytic residues [active] 653045014808 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 653045014809 putative acyl-acceptor binding pocket; other site 653045014810 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 653045014811 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 653045014812 tetramer interface [polypeptide binding]; other site 653045014813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045014814 catalytic residue [active] 653045014815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014816 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 653045014817 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 653045014818 active site 653045014819 catalytic site [active] 653045014820 putative acetyltransferase; Provisional; Region: PRK03624 653045014821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045014822 Coenzyme A binding pocket [chemical binding]; other site 653045014823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045014824 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045014825 active site 653045014826 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045014827 Peptidase family M48; Region: Peptidase_M48; cl12018 653045014828 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 653045014829 active site 653045014830 Cupin domain; Region: Cupin_2; cl09118 653045014831 Pirin-related protein [General function prediction only]; Region: COG1741 653045014832 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 653045014833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045014835 putative substrate translocation pore; other site 653045014836 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045014837 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045014838 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045014839 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045014840 Protein of unknown function (DUF461); Region: DUF461; cl01071 653045014841 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045014842 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045014843 active site 653045014844 metal binding site [ion binding]; metal-binding site 653045014845 Probable cobalt transporter subunit (CbtA); Region: CbtA; cl02266 653045014846 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 653045014847 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 653045014848 cobalamin binding residues [chemical binding]; other site 653045014849 putative BtuC binding residues; other site 653045014850 dimer interface [polypeptide binding]; other site 653045014851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045014852 putative substrate translocation pore; other site 653045014853 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 653045014854 active site 653045014855 LysE type translocator; Region: LysE; cl00565 653045014856 formate dehydrogenase; Provisional; Region: PRK07574 653045014857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014858 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045014859 Helix-turn-helix domains; Region: HTH; cl00088 653045014860 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045014861 dimerization interface [polypeptide binding]; other site 653045014862 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 653045014863 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045014864 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045014865 Cupin domain; Region: Cupin_2; cl09118 653045014866 Helix-turn-helix domain; Region: HTH_18; pfam12833 653045014867 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045014868 Helix-turn-helix domains; Region: HTH; cl00088 653045014869 hypothetical protein; Provisional; Region: PRK06834 653045014870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014872 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 653045014873 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 653045014874 AMP-binding enzyme; Region: AMP-binding; cl15778 653045014875 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014876 putative NADP binding site [chemical binding]; other site 653045014877 active site 653045014878 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014879 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045014880 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045014881 active site 653045014882 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045014883 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045014884 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014885 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045014886 Enoylreductase; Region: PKS_ER; smart00829 653045014887 NAD(P) binding site [chemical binding]; other site 653045014888 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014889 putative NADP binding site [chemical binding]; other site 653045014890 active site 653045014891 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014892 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045014893 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045014894 active site 653045014895 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045014896 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045014897 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014898 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045014899 Enoylreductase; Region: PKS_ER; smart00829 653045014900 NAD(P) binding site [chemical binding]; other site 653045014901 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014902 putative NADP binding site [chemical binding]; other site 653045014903 active site 653045014904 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014905 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045014906 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045014907 active site 653045014908 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045014909 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045014910 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045014911 NADP binding site [chemical binding]; other site 653045014912 active site 653045014913 acyl-CoA synthetase; Validated; Region: PRK06060 653045014914 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014915 Erythronolide synthase docking; Region: Docking; pfam08990 653045014916 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045014917 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045014918 active site 653045014919 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045014920 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045014921 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045014922 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014923 putative NADP binding site [chemical binding]; other site 653045014924 active site 653045014925 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014926 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045014927 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045014928 active site 653045014929 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045014930 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045014931 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045014932 NADP binding site [chemical binding]; other site 653045014933 active site 653045014934 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014935 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045014936 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045014937 active site 653045014938 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045014939 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045014940 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014941 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045014942 Enoylreductase; Region: PKS_ER; smart00829 653045014943 NAD(P) binding site [chemical binding]; other site 653045014944 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014945 putative NADP binding site [chemical binding]; other site 653045014946 active site 653045014947 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014948 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045014949 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045014950 active site 653045014951 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045014952 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045014953 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045014954 putative NADP binding site [chemical binding]; other site 653045014955 active site 653045014956 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014957 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 653045014958 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 653045014959 FkbH-like domain; Region: FkbH; TIGR01686 653045014960 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045014961 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045014962 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045014963 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 653045014964 active site 653045014965 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045014966 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 653045014967 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045014968 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045014969 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045014970 O-methyltransferase; Region: Methyltransf_3; pfam01596 653045014971 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014972 Predicted ATPase [General function prediction only]; Region: COG3899 653045014973 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 653045014974 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045014975 DNA binding residues [nucleotide binding] 653045014976 dimerization interface [polypeptide binding]; other site 653045014977 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 653045014978 dimer interface [polypeptide binding]; other site 653045014979 active site 653045014980 metal binding site [ion binding]; metal-binding site 653045014981 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 653045014982 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 653045014983 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045014984 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045014985 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045014986 DNA binding residues [nucleotide binding] 653045014987 dimerization interface [polypeptide binding]; other site 653045014988 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 653045014989 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045014990 motif II; other site 653045014991 Helix-turn-helix domains; Region: HTH; cl00088 653045014992 Uncharacterized conserved protein [Function unknown]; Region: COG5276 653045014993 Domain of unknown function (DUF305); Region: DUF305; cl15795 653045014994 ferredoxin-NADP+ reductase; Region: PLN02852 653045014995 xanthine permease; Region: pbuX; TIGR03173 653045014996 Helix-turn-helix domains; Region: HTH; cl00088 653045014997 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 653045014998 active site 653045014999 FMN binding site [chemical binding]; other site 653045015000 substrate binding site [chemical binding]; other site 653045015001 homotetramer interface [polypeptide binding]; other site 653045015002 catalytic residue [active] 653045015003 VPS10 domain; Region: VPS10; smart00602 653045015004 VPS10 domain; Region: VPS10; smart00602 653045015005 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 653045015006 ligand binding site [chemical binding]; other site 653045015007 active site 653045015008 UGI interface [polypeptide binding]; other site 653045015009 catalytic site [active] 653045015010 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 653045015011 Scramblase; Region: Scramblase; cl02043 653045015012 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 653045015013 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 653045015014 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 653045015015 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045015016 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045015017 motif II; other site 653045015018 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 653045015019 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045015020 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 653045015021 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045015022 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 653045015023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045015024 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 653045015025 Ca2+ binding site [ion binding]; other site 653045015026 EF-hand domain pair; Region: EF_hand_6; pfam13833 653045015027 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 653045015028 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045015029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045015030 dimer interface [polypeptide binding]; other site 653045015031 conserved gate region; other site 653045015032 putative PBP binding loops; other site 653045015033 ABC-ATPase subunit interface; other site 653045015034 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 653045015035 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 653045015036 Walker A/P-loop; other site 653045015037 ATP binding site [chemical binding]; other site 653045015038 Q-loop/lid; other site 653045015039 ABC transporter signature motif; other site 653045015040 Walker B; other site 653045015041 D-loop; other site 653045015042 H-loop/switch region; other site 653045015043 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 653045015044 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045015045 substrate binding pocket [chemical binding]; other site 653045015046 membrane-bound complex binding site; other site 653045015047 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045015048 Helix-turn-helix domains; Region: HTH; cl00088 653045015049 Predicted membrane protein [Function unknown]; Region: COG2311 653045015050 Protein of unknown function (DUF418); Region: DUF418; cl12135 653045015051 Protein of unknown function (DUF418); Region: DUF418; cl12135 653045015052 Helix-turn-helix domains; Region: HTH; cl00088 653045015053 Cupin domain; Region: Cupin_2; cl09118 653045015054 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045015055 Chitin binding domain; Region: Chitin_bind_3; cl03871 653045015056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4529 653045015057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 653045015059 Rrf2 family protein; Region: rrf2_super; TIGR00738 653045015060 Helix-turn-helix domains; Region: HTH; cl00088 653045015061 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045015062 CHAT domain; Region: CHAT; pfam12770 653045015063 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045015064 tocopherol O-methyltransferase; Region: PLN02244 653045015065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045015066 S-adenosylmethionine binding site [chemical binding]; other site 653045015067 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045015068 N-acetyltransferase; Region: Acetyltransf_2; cl00949 653045015069 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 653045015070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015072 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045015073 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 653045015074 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 653045015075 Sulfatase; Region: Sulfatase; cl10460 653045015076 YceI-like domain; Region: YceI; cl01001 653045015077 aconitate hydratase; Validated; Region: PRK07229 653045015078 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 653045015079 substrate binding site [chemical binding]; other site 653045015080 ligand binding site [chemical binding]; other site 653045015081 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 653045015082 substrate binding site [chemical binding]; other site 653045015083 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 653045015084 active site 653045015085 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 653045015086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045015087 dimer interface [polypeptide binding]; other site 653045015088 conserved gate region; other site 653045015089 putative PBP binding loops; other site 653045015090 ABC-ATPase subunit interface; other site 653045015091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045015092 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 653045015093 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045015094 Walker A/P-loop; other site 653045015095 ATP binding site [chemical binding]; other site 653045015096 Q-loop/lid; other site 653045015097 ABC transporter signature motif; other site 653045015098 Walker B; other site 653045015099 D-loop; other site 653045015100 H-loop/switch region; other site 653045015101 NMT1-like family; Region: NMT1_2; cl15260 653045015102 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 653045015103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045015104 active site 653045015105 Phosphate transporter family; Region: PHO4; cl00396 653045015106 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045015107 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045015108 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045015109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045015110 active site 653045015111 phosphorylation site [posttranslational modification] 653045015112 intermolecular recognition site; other site 653045015113 dimerization interface [polypeptide binding]; other site 653045015114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045015115 DNA binding residues [nucleotide binding] 653045015116 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 653045015117 Histidine kinase; Region: HisKA_3; pfam07730 653045015118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045015119 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045015120 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 653045015121 Walker A/P-loop; other site 653045015122 ATP binding site [chemical binding]; other site 653045015123 Q-loop/lid; other site 653045015124 ABC transporter signature motif; other site 653045015125 Walker B; other site 653045015126 D-loop; other site 653045015127 H-loop/switch region; other site 653045015128 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045015129 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 653045015130 inhibitor-cofactor binding pocket; inhibition site 653045015131 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045015132 catalytic residue [active] 653045015133 Helix-turn-helix domains; Region: HTH; cl00088 653045015134 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 653045015135 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045015136 putative dimerization interface [polypeptide binding]; other site 653045015137 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 653045015138 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 653045015139 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 653045015140 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045015141 Helix-turn-helix domains; Region: HTH; cl00088 653045015142 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045015143 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 653045015144 NAD binding site [chemical binding]; other site 653045015145 catalytic residues [active] 653045015146 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 653045015147 putative active site [active] 653045015148 putative metal binding site [ion binding]; other site 653045015149 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 653045015150 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045015151 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045015152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045015153 catalytic residue [active] 653045015154 Acetoacetate decarboxylase (ADC); Region: ADC; cl01919 653045015155 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045015156 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045015157 DNA-binding site [nucleotide binding]; DNA binding site 653045015158 UTRA domain; Region: UTRA; cl01230 653045015159 FAD dependent oxidoreductase TIGR03364; Region: HpnW_proposed 653045015160 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 653045015161 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045015162 motif II; other site 653045015163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045015164 dimer interface [polypeptide binding]; other site 653045015165 conserved gate region; other site 653045015166 putative PBP binding loops; other site 653045015167 ABC-ATPase subunit interface; other site 653045015168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045015169 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 653045015170 Helix-turn-helix domains; Region: HTH; cl00088 653045015171 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415 653045015172 Helix-turn-helix domains; Region: HTH; cl00088 653045015173 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045015174 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045015175 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 653045015176 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 653045015177 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 653045015178 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 653045015179 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 653045015180 FOG: PKD repeat [General function prediction only]; Region: COG3291 653045015181 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 653045015182 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 653045015183 metal binding site [ion binding]; metal-binding site 653045015184 ligand binding site [chemical binding]; other site 653045015185 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045015186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015187 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045015188 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 653045015189 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045015190 metal binding site [ion binding]; metal-binding site 653045015191 substrate binding pocket [chemical binding]; other site 653045015192 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 653045015193 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045015194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015195 NAD(P) binding site [chemical binding]; other site 653045015196 active site 653045015197 Glycoside hydrolase family 99, an endo-alpha-1,2-mannosidase; Region: GH99; cd11574 653045015198 ligand binding site [chemical binding]; other site 653045015199 putative catalytic site [active] 653045015200 Uncharacterized glycoside hydrolase family 99-like domain; Region: GH99_GH71_like_2; cd11576 653045015201 putative ligand binding site [chemical binding]; other site 653045015202 putative catalytic site [active] 653045015203 Cupin domain; Region: Cupin_2; cl09118 653045015204 Winged helix-turn helix; Region: HTH_29; pfam13551 653045015205 Helix-turn-helix domains; Region: HTH; cl00088 653045015206 Winged helix-turn helix; Region: HTH_33; pfam13592 653045015207 Integrase core domain; Region: rve; cl01316 653045015208 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 653045015209 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045015210 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 653045015211 Moco binding site; other site 653045015212 metal coordination site [ion binding]; other site 653045015213 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 653045015214 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 653045015215 gating phenylalanine in ion channel; other site 653045015216 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045015217 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045015218 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 653045015219 NAD(P) binding site [chemical binding]; other site 653045015220 catalytic residues [active] 653045015221 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 653045015222 Domain of unknown function (DUF4291); Region: DUF4291; pfam14124 653045015223 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045015224 MULE transposase domain; Region: MULE; pfam10551 653045015225 Integrase core domain; Region: rve; cl01316 653045015226 Integrase core domain; Region: rve_3; cl15866 653045015227 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045015228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045015229 active site 653045015230 phosphorylation site [posttranslational modification] 653045015231 intermolecular recognition site; other site 653045015232 dimerization interface [polypeptide binding]; other site 653045015233 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045015234 DNA binding residues [nucleotide binding] 653045015235 dimerization interface [polypeptide binding]; other site 653045015236 Histidine kinase; Region: HisKA_3; pfam07730 653045015237 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045015238 short chain dehydrogenase; Provisional; Region: PRK06940 653045015239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015240 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045015241 Helix-turn-helix domains; Region: HTH; cl00088 653045015242 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 653045015243 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045015244 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045015245 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045015246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045015247 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045015248 dimer interface [polypeptide binding]; other site 653045015249 phosphorylation site [posttranslational modification] 653045015250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045015251 ATP binding site [chemical binding]; other site 653045015252 Mg2+ binding site [ion binding]; other site 653045015253 G-X-G motif; other site 653045015254 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045015255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045015256 active site 653045015257 phosphorylation site [posttranslational modification] 653045015258 intermolecular recognition site; other site 653045015259 dimerization interface [polypeptide binding]; other site 653045015260 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045015261 DNA binding site [nucleotide binding] 653045015262 Cupin domain; Region: Cupin_2; cl09118 653045015263 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045015264 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015265 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 653045015266 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 653045015267 THF binding site; other site 653045015268 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 653045015269 substrate binding site [chemical binding]; other site 653045015270 THF binding site; other site 653045015271 zinc-binding site [ion binding]; other site 653045015272 Cupin domain; Region: Cupin_2; cl09118 653045015273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015274 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045015275 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015276 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 653045015277 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045015278 putative NAD(P) binding site [chemical binding]; other site 653045015279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045015280 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045015281 Epoxide hydrolase N terminus; Region: EHN; pfam06441 653045015282 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045015283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015284 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045015285 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015286 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 653045015287 FMN binding site [chemical binding]; other site 653045015288 active site 653045015289 substrate binding site [chemical binding]; other site 653045015290 catalytic residue [active] 653045015291 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045015292 Helix-turn-helix domains; Region: HTH; cl00088 653045015293 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045015294 Helix-turn-helix domains; Region: HTH; cl00088 653045015295 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045015296 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045015297 active site 653045015298 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 653045015299 NADP binding site [chemical binding]; other site 653045015300 homodimer interface [polypeptide binding]; other site 653045015301 active site 653045015302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015303 NmrA-like family; Region: NmrA; pfam05368 653045015304 NAD(P) binding site [chemical binding]; other site 653045015305 active site 653045015306 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 653045015307 Helix-turn-helix domains; Region: HTH; cl00088 653045015308 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045015309 dimerization interface [polypeptide binding]; other site 653045015310 substrate binding pocket [chemical binding]; other site 653045015311 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045015312 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045015313 active site 653045015314 catalytic tetrad [active] 653045015315 Domain of unknown function (DUF336); Region: DUF336; cl01249 653045015316 MFS transport protein AraJ; Provisional; Region: PRK10091 653045015317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045015318 Transcriptional regulators [Transcription]; Region: MarR; COG1846 653045015319 Helix-turn-helix domains; Region: HTH; cl00088 653045015320 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 653045015321 Helix-turn-helix domains; Region: HTH; cl00088 653045015322 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 653045015323 dimerization interface [polypeptide binding]; other site 653045015324 substrate binding pocket [chemical binding]; other site 653045015325 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045015326 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045015327 active site 653045015328 catalytic tetrad [active] 653045015329 Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821 653045015330 putative hydrophobic ligand binding site [chemical binding]; other site 653045015331 protein interface [polypeptide binding]; other site 653045015332 gate; other site 653045015333 hypothetical protein; Provisional; Region: PRK08244 653045015334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015335 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015337 Helix-turn-helix domains; Region: HTH; cl00088 653045015338 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045015339 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045015340 Helix-turn-helix domains; Region: HTH; cl00088 653045015341 Helix-turn-helix domains; Region: HTH; cl00088 653045015342 Helix-turn-helix domains; Region: HTH; cl00088 653045015343 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045015344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015345 NAD(P) binding site [chemical binding]; other site 653045015346 active site 653045015347 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 653045015348 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045015349 NAD binding site [chemical binding]; other site 653045015350 catalytic Zn binding site [ion binding]; other site 653045015351 structural Zn binding site [ion binding]; other site 653045015352 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 653045015353 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 653045015354 PaaX-like protein; Region: PaaX; pfam07848 653045015355 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 653045015356 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 653045015357 homotrimer interaction site [polypeptide binding]; other site 653045015358 putative active site [active] 653045015359 Cupin domain; Region: Cupin_2; cl09118 653045015360 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 653045015361 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 653045015362 active site 653045015363 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 653045015364 catalytic triad [active] 653045015365 dimer interface [polypeptide binding]; other site 653045015366 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 653045015367 AMP-binding enzyme; Region: AMP-binding; cl15778 653045015368 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045015369 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 653045015370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015371 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 653045015372 active site 653045015373 FMN binding site [chemical binding]; other site 653045015374 substrate binding site [chemical binding]; other site 653045015375 homotetramer interface [polypeptide binding]; other site 653045015376 catalytic residue [active] 653045015377 Epoxide hydrolase N terminus; Region: EHN; pfam06441 653045015378 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 653045015379 OpgC protein; Region: OpgC_C; cl00792 653045015380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045015381 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045015382 Probable transposase; Region: OrfB_IS605; pfam01385 653045015383 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045015384 enoyl-CoA hydratase; Provisional; Region: PRK08252 653045015385 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045015386 substrate binding site [chemical binding]; other site 653045015387 oxyanion hole (OAH) forming residues; other site 653045015388 trimer interface [polypeptide binding]; other site 653045015389 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 653045015390 Zn binding site [ion binding]; other site 653045015391 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045015392 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045015393 active site 653045015394 phosphorylation site [posttranslational modification] 653045015395 intermolecular recognition site; other site 653045015396 dimerization interface [polypeptide binding]; other site 653045015397 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045015398 DNA binding residues [nucleotide binding] 653045015399 dimerization interface [polypeptide binding]; other site 653045015400 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 653045015401 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 653045015402 Walker A/P-loop; other site 653045015403 ATP binding site [chemical binding]; other site 653045015404 Q-loop/lid; other site 653045015405 ABC transporter signature motif; other site 653045015406 Walker B; other site 653045015407 D-loop; other site 653045015408 H-loop/switch region; other site 653045015409 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 653045015410 ABC-ATPase subunit interface; other site 653045015411 dimer interface [polypeptide binding]; other site 653045015412 putative PBP binding regions; other site 653045015413 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 653045015414 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 653045015415 putative ligand binding residues [chemical binding]; other site 653045015416 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 653045015417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045015418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045015419 Uncharacterized conserved protein [Function unknown]; Region: COG2128 653045015420 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045015421 Predicted small integral membrane protein (DUF2165); Region: DUF2165; cl02290 653045015422 Domain of unknown function (DUF1996); Region: DUF1996; pfam09362 653045015423 Domain of unknown function (DUF305); Region: DUF305; cl15795 653045015424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045015425 salt bridge; other site 653045015426 non-specific DNA binding site [nucleotide binding]; other site 653045015427 sequence-specific DNA binding site [nucleotide binding]; other site 653045015428 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045015429 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045015430 NAD(P) binding site [chemical binding]; other site 653045015431 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045015432 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045015433 active site 653045015434 catalytic tetrad [active] 653045015435 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045015436 Helix-turn-helix domains; Region: HTH; cl00088 653045015437 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045015438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045015439 Helix-turn-helix domains; Region: HTH; cl00088 653045015440 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 653045015441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015442 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045015443 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 653045015444 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 653045015445 NAD binding site [chemical binding]; other site 653045015446 catalytic Zn binding site [ion binding]; other site 653045015447 substrate binding site [chemical binding]; other site 653045015448 structural Zn binding site [ion binding]; other site 653045015449 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 653045015450 dimer interface [polypeptide binding]; other site 653045015451 NADP binding site [chemical binding]; other site 653045015452 catalytic residues [active] 653045015453 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 653045015454 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045015455 phosphate binding site [ion binding]; other site 653045015456 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045015457 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 653045015458 putative NAD(P) binding site [chemical binding]; other site 653045015459 putative active site [active] 653045015460 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045015461 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045015462 putative substrate translocation pore; other site 653045015463 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045015464 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 653045015465 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 653045015466 active site 653045015467 NAD binding site [chemical binding]; other site 653045015468 metal binding site [ion binding]; metal-binding site 653045015469 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 653045015470 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 653045015471 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 653045015472 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045015473 DNA binding residues [nucleotide binding] 653045015474 dimer interface [polypeptide binding]; other site 653045015475 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 653045015476 nudix motif; other site 653045015477 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045015478 structural tetrad; other site 653045015479 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045015480 structural tetrad; other site 653045015481 Domain of unknown function (DUF336); Region: DUF336; cl01249 653045015482 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 653045015483 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 653045015484 putative active site [active] 653045015485 Helix-turn-helix domains; Region: HTH; cl00088 653045015486 short chain dehydrogenase; Provisional; Region: PRK08263 653045015487 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045015488 NADP binding site [chemical binding]; other site 653045015489 active site 653045015490 steroid binding site; other site 653045015491 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045015492 Helix-turn-helix domains; Region: HTH; cl00088 653045015493 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 653045015494 Amidase; Region: Amidase; cl11426 653045015495 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045015496 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 653045015497 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 653045015498 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045015499 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 653045015500 Sarcosine oxidase, delta subunit family; Region: SoxD; cl01767 653045015501 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 653045015502 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015503 Cysteine dioxygenase type I; Region: CDO_I; cl15835 653045015504 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 653045015505 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 653045015506 dimer interface [polypeptide binding]; other site 653045015507 active site 653045015508 glycine-pyridoxal phosphate binding site [chemical binding]; other site 653045015509 folate binding site [chemical binding]; other site 653045015510 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045015511 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045015512 DNA-binding site [nucleotide binding]; DNA binding site 653045015513 FCD domain; Region: FCD; cl11656 653045015514 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 653045015515 active site 653045015516 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 653045015517 active site 653045015518 Helix-turn-helix domains; Region: HTH; cl00088 653045015519 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 653045015520 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045015521 putative NAD(P) binding site [chemical binding]; other site 653045015522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045015523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045015524 DNA binding site [nucleotide binding] 653045015525 domain linker motif; other site 653045015526 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045015527 ligand binding site [chemical binding]; other site 653045015528 dimerization interface [polypeptide binding]; other site 653045015529 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 653045015530 FAD binding site [chemical binding]; other site 653045015531 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 653045015532 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 653045015533 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 653045015534 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 653045015535 AMP-binding enzyme; Region: AMP-binding; cl15778 653045015536 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045015537 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045015538 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045015539 DNA-binding site [nucleotide binding]; DNA binding site 653045015540 FCD domain; Region: FCD; cl11656 653045015541 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 653045015542 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045015543 Walker A/P-loop; other site 653045015544 ATP binding site [chemical binding]; other site 653045015545 Q-loop/lid; other site 653045015546 ABC transporter signature motif; other site 653045015547 Walker B; other site 653045015548 D-loop; other site 653045015549 H-loop/switch region; other site 653045015550 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 653045015551 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045015552 TM-ABC transporter signature motif; other site 653045015553 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045015554 TM-ABC transporter signature motif; other site 653045015555 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 653045015556 active site pocket [active] 653045015557 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 653045015558 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 653045015559 ligand binding site [chemical binding]; other site 653045015560 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 653045015561 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 653045015562 putative sugar binding sites [chemical binding]; other site 653045015563 Q-X-W motif; other site 653045015564 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 653045015565 active site 653045015566 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 653045015567 active site 653045015568 catalytic residues [active] 653045015569 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 653045015570 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 653045015571 putative sugar binding sites [chemical binding]; other site 653045015572 Q-X-W motif; other site 653045015573 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045015574 phosphopeptide binding site; other site 653045015575 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045015576 phosphopeptide binding site; other site 653045015577 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 653045015578 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045015579 Walker A/P-loop; other site 653045015580 ATP binding site [chemical binding]; other site 653045015581 Q-loop/lid; other site 653045015582 ABC transporter signature motif; other site 653045015583 Walker B; other site 653045015584 D-loop; other site 653045015585 H-loop/switch region; other site 653045015586 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045015587 Helix-turn-helix domains; Region: HTH; cl00088 653045015588 DNA-binding site [nucleotide binding]; DNA binding site 653045015589 FCD domain; Region: FCD; cl11656 653045015590 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 653045015591 Nitronate monooxygenase; Region: NMO; pfam03060 653045015592 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 653045015593 FMN binding site [chemical binding]; other site 653045015594 substrate binding site [chemical binding]; other site 653045015595 putative catalytic residue [active] 653045015596 Cupin domain; Region: Cupin_2; cl09118 653045015597 Streptomyces laminarinase-like, member of glycosyl hydrolase family 16; Region: GH16_Strep_laminarinase_like; cd02182 653045015598 active site 653045015599 catalytic residues [active] 653045015600 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 653045015601 dihydroxyacetone kinase; Provisional; Region: PRK14479 653045015602 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 653045015603 DAK2 domain; Region: Dak2; cl03685 653045015604 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 653045015605 L-xylulose kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 653045015606 putative N- and C-terminal domain interface [polypeptide binding]; other site 653045015607 putative active site [active] 653045015608 putative MgATP binding site [chemical binding]; other site 653045015609 catalytic site [active] 653045015610 metal binding site [ion binding]; metal-binding site 653045015611 putative xylulose binding site [chemical binding]; other site 653045015612 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 653045015613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015614 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 653045015615 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045015616 motif II; other site 653045015617 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045015618 Helix-turn-helix domains; Region: HTH; cl00088 653045015619 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045015620 polyol permease family; Region: 2A0118; TIGR00897 653045015621 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045015622 putative substrate translocation pore; other site 653045015623 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045015624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045015625 non-specific DNA binding site [nucleotide binding]; other site 653045015626 salt bridge; other site 653045015627 sequence-specific DNA binding site [nucleotide binding]; other site 653045015628 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045015629 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045015630 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 653045015631 Helix-turn-helix domains; Region: HTH; cl00088 653045015632 Helix-turn-helix domains; Region: HTH; cl00088 653045015633 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 653045015634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045015635 putative substrate translocation pore; other site 653045015636 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045015637 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 653045015638 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045015639 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045015640 active site 653045015641 Shikimate kinase; Region: SKI; pfam01202 653045015642 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045015643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045015644 non-specific DNA binding site [nucleotide binding]; other site 653045015645 salt bridge; other site 653045015646 sequence-specific DNA binding site [nucleotide binding]; other site 653045015647 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045015648 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045015649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045015650 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 653045015651 Helix-turn-helix domains; Region: HTH; cl00088 653045015652 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045015653 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045015654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045015655 phosphoenolpyruvate synthase; Validated; Region: PRK06241 653045015656 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 653045015657 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 653045015658 Helix-turn-helix domains; Region: HTH; cl00088 653045015659 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045015660 Predicted ATPase [General function prediction only]; Region: COG3903 653045015661 hypothetical protein; Provisional; Region: PRK06834 653045015662 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015663 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015664 Uncharacterized protein conserved in bacteria (DUF2236); Region: DUF2236; cl01472 653045015665 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 653045015666 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045015667 substrate binding pocket [chemical binding]; other site 653045015668 chain length determination region; other site 653045015669 substrate-Mg2+ binding site; other site 653045015670 catalytic residues [active] 653045015671 aspartate-rich region 1; other site 653045015672 active site lid residues [active] 653045015673 aspartate-rich region 2; other site 653045015674 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045015675 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045015676 DNA binding site [nucleotide binding] 653045015677 domain linker motif; other site 653045015678 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045015679 dimerization interface [polypeptide binding]; other site 653045015680 ligand binding site [chemical binding]; other site 653045015681 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 653045015682 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045015683 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 653045015684 Ca binding site [ion binding]; other site 653045015685 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 653045015686 Carbohydrate Binding Module family 35 (CBM35); appended mainly to enzymes that bind alpha-D-galactose (CBM35-Gal), including glycoside hydrolase (GH) families GH31 and GH43; Region: CBM35_galactosidase-like; cd04081 653045015687 Ca binding site [ion binding]; other site 653045015688 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 653045015689 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 653045015690 Helix-turn-helix domains; Region: HTH; cl00088 653045015691 Helix-turn-helix domains; Region: HTH; cl00088 653045015692 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045015693 Helix-turn-helix domains; Region: HTH; cl00088 653045015694 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 653045015695 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 653045015696 active site 653045015697 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 653045015698 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 653045015699 Amidase; Region: Amidase; cl11426 653045015700 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 653045015701 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 653045015702 tetramer interface [polypeptide binding]; other site 653045015703 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045015704 catalytic residue [active] 653045015705 Helix-turn-helix domains; Region: HTH; cl00088 653045015706 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045015707 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015708 NAD(P) binding site [chemical binding]; other site 653045015709 active site 653045015710 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045015711 Helix-turn-helix domains; Region: HTH; cl00088 653045015712 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 653045015713 classical (c) SDRs; Region: SDR_c; cd05233 653045015714 NAD(P) binding site [chemical binding]; other site 653045015715 active site 653045015716 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 653045015717 Helix-turn-helix domains; Region: HTH; cl00088 653045015718 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045015719 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045015720 conserved cys residue [active] 653045015721 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015722 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045015723 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045015724 putative NAD(P) binding site [chemical binding]; other site 653045015725 acyl-CoA synthetase; Validated; Region: PRK08316 653045015726 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656 653045015727 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045015728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045015729 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 653045015730 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045015731 NAD(P) binding site [chemical binding]; other site 653045015732 Cupin domain; Region: Cupin_2; cl09118 653045015733 Helix-turn-helix domains; Region: HTH; cl00088 653045015734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045015735 DNA-binding interface [nucleotide binding]; DNA binding site 653045015736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015737 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015738 NADH(P)-binding; Region: NAD_binding_10; pfam13460 653045015739 NAD(P) binding site [chemical binding]; other site 653045015740 active site 653045015741 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045015742 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 653045015743 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015744 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 653045015745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045015746 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045015747 putative substrate translocation pore; other site 653045015748 LamB/YcsF family; Region: LamB_YcsF; cl00664 653045015749 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 653045015750 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 653045015751 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 653045015752 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045015753 classical (c) SDRs; Region: SDR_c; cd05233 653045015754 NAD(P) binding site [chemical binding]; other site 653045015755 active site 653045015756 aspartate aminotransferase; Provisional; Region: PRK05764 653045015757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045015758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045015759 homodimer interface [polypeptide binding]; other site 653045015760 catalytic residue [active] 653045015761 Helix-turn-helix domains; Region: HTH; cl00088 653045015762 glutamate dehydrogenase; Provisional; Region: PRK09414 653045015763 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 653045015764 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 653045015765 NAD(P) binding site [chemical binding]; other site 653045015766 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045015767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045015768 active site 653045015769 catalytic tetrad [active] 653045015770 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 653045015771 Putative cyclase; Region: Cyclase; cl00814 653045015772 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 653045015773 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 653045015774 PYR/PP interface [polypeptide binding]; other site 653045015775 dimer interface [polypeptide binding]; other site 653045015776 TPP binding site [chemical binding]; other site 653045015777 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045015778 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 653045015779 TPP-binding site [chemical binding]; other site 653045015780 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 653045015781 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 653045015782 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 653045015783 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 653045015784 ligand binding site [chemical binding]; other site 653045015785 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045015786 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 653045015787 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045015788 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045015789 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045015790 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045015791 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045015792 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045015793 putative NAD(P) binding site [chemical binding]; other site 653045015794 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045015795 Helix-turn-helix domains; Region: HTH; cl00088 653045015796 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 653045015797 hypothetical protein; Provisional; Region: PRK08204 653045015798 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045015799 active site 653045015800 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045015801 active site 653045015802 Flavin Reductases; Region: FlaRed; cl00801 653045015803 Helix-turn-helix domains; Region: HTH; cl00088 653045015804 short chain dehydrogenase; Provisional; Region: PRK06523 653045015805 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015806 NAD(P) binding site [chemical binding]; other site 653045015807 active site 653045015808 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045015809 Helix-turn-helix domains; Region: HTH; cl00088 653045015810 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 653045015811 Helix-turn-helix domain; Region: HTH_18; pfam12833 653045015812 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045015813 short chain dehydrogenase; Provisional; Region: PRK06523 653045015814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015815 NAD(P) binding site [chemical binding]; other site 653045015816 active site 653045015817 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045015818 Helix-turn-helix domains; Region: HTH; cl00088 653045015819 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045015820 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045015821 DNA-binding site [nucleotide binding]; DNA binding site 653045015822 FCD domain; Region: FCD; cl11656 653045015823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045015824 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 653045015825 putative metal binding site [ion binding]; other site 653045015826 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045015827 classical (c) SDRs; Region: SDR_c; cd05233 653045015828 NAD(P) binding site [chemical binding]; other site 653045015829 active site 653045015830 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 653045015831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045015832 Helix-turn-helix domains; Region: HTH; cl00088 653045015833 WHG domain; Region: WHG; pfam13305 653045015834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045015835 Helix-turn-helix domains; Region: HTH; cl00088 653045015836 hypothetical protein; Provisional; Region: PRK07538 653045015837 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015838 Clp amino terminal domain; Region: Clp_N; pfam02861 653045015839 Clp amino terminal domain; Region: Clp_N; pfam02861 653045015840 Clp amino terminal domain; Region: Clp_N; pfam02861 653045015841 amidase; Provisional; Region: PRK06170 653045015842 Amidase; Region: Amidase; cl11426 653045015843 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 653045015844 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045015845 DNA binding residues [nucleotide binding] 653045015846 putative dimer interface [polypeptide binding]; other site 653045015847 putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800 653045015848 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 653045015849 HEAT repeats; Region: HEAT_2; pfam13646 653045015850 metal binding site [ion binding]; metal-binding site 653045015851 substrate binding site [chemical binding]; other site 653045015852 Cupin domain; Region: Cupin_2; cl09118 653045015853 HEAT repeats; Region: HEAT_2; pfam13646 653045015854 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 653045015855 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045015856 sugar binding site [chemical binding]; other site 653045015857 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045015858 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045015859 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 653045015860 putative metal binding site [ion binding]; other site 653045015861 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 653045015862 Right handed beta helix region; Region: Beta_helix; pfam13229 653045015863 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045015864 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 653045015865 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 653045015866 tetramer interface [polypeptide binding]; other site 653045015867 active site 653045015868 Mg2+/Mn2+ binding site [ion binding]; other site 653045015869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045015870 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045015871 Helix-turn-helix domains; Region: HTH; cl00088 653045015872 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045015873 Helix-turn-helix domains; Region: HTH; cl00088 653045015874 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 653045015875 Catalytic domain of Helicobacter pylori peptidoglycan deacetylase (HpPgdA) and similar proteins; Region: CE4_HpPgdA_like; cd10938 653045015876 active site 653045015877 catalytic site [active] 653045015878 Zn binding site [ion binding]; other site 653045015879 tetramer interface [polypeptide binding]; other site 653045015880 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045015881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045015882 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045015883 classical (c) SDRs; Region: SDR_c; cd05233 653045015884 NAD(P) binding site [chemical binding]; other site 653045015885 active site 653045015886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015887 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 653045015888 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 653045015889 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 653045015890 metal binding site [ion binding]; metal-binding site 653045015891 dimer interface [polypeptide binding]; other site 653045015892 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 653045015893 NAD-dependent deacetylase; Provisional; Region: PRK05333 653045015894 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045015895 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 653045015896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045015897 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045015898 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045015899 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045015900 DNA binding site [nucleotide binding] 653045015901 domain linker motif; other site 653045015902 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045015903 dimerization interface [polypeptide binding]; other site 653045015904 ligand binding site [chemical binding]; other site 653045015905 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 653045015906 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045015907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045015908 putative PBP binding loops; other site 653045015909 ABC-ATPase subunit interface; other site 653045015910 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045015911 dimer interface [polypeptide binding]; other site 653045015912 conserved gate region; other site 653045015913 putative PBP binding loops; other site 653045015914 ABC-ATPase subunit interface; other site 653045015915 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 653045015916 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 653045015917 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 653045015918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045015919 Walker A/P-loop; other site 653045015920 ATP binding site [chemical binding]; other site 653045015921 Q-loop/lid; other site 653045015922 ABC transporter signature motif; other site 653045015923 Walker B; other site 653045015924 D-loop; other site 653045015925 H-loop/switch region; other site 653045015926 Helix-turn-helix domains; Region: HTH; cl00088 653045015927 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045015928 substrate binding site [chemical binding]; other site 653045015929 oxyanion hole (OAH) forming residues; other site 653045015930 trimer interface [polypeptide binding]; other site 653045015931 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 653045015932 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 653045015933 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 653045015934 active site 653045015935 SUKH-4 immunity protein; Region: SUKH-4; pfam14435 653045015936 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07819 653045015937 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045015938 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045015939 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 653045015940 B12 binding site [chemical binding]; other site 653045015941 cobalt ligand [ion binding]; other site 653045015942 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 653045015943 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045015944 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 653045015945 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 653045015946 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045015947 S-adenosylmethionine binding site [chemical binding]; other site 653045015948 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 653045015949 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 653045015950 Sodium:solute symporter family; Region: SSF; cl00456 653045015951 Protein of unknown function (DUF3311); Region: DUF3311; pfam11755 653045015952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045015953 non-specific DNA binding site [nucleotide binding]; other site 653045015954 salt bridge; other site 653045015955 sequence-specific DNA binding site [nucleotide binding]; other site 653045015956 Cupin domain; Region: Cupin_2; cl09118 653045015957 Endo-beta-N-acetylglucosaminidases are bacterial chitinases that hydrolyze the chitin core of various asparagine (N)-linked glycans and glycoproteins. The endo-beta-N-acetylglucosaminidases have a glycosyl hydrolase family 18 (GH18) catalytic domain; Region: GH18_EndoS-like; cd06542 653045015958 active site 653045015959 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 653045015960 active site 653045015961 catalytic triad [active] 653045015962 oxyanion hole [active] 653045015963 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045015964 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045015965 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 653045015966 Walker A/P-loop; other site 653045015967 ATP binding site [chemical binding]; other site 653045015968 Q-loop/lid; other site 653045015969 ABC transporter signature motif; other site 653045015970 Walker B; other site 653045015971 D-loop; other site 653045015972 H-loop/switch region; other site 653045015973 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045015974 glycosyltransferase, MGT family; Region: MGT; TIGR01426 653045015975 active site 653045015976 TDP-binding site; other site 653045015977 acceptor substrate-binding pocket; other site 653045015978 homodimer interface [polypeptide binding]; other site 653045015979 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045015980 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045015981 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045015982 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 653045015983 active site 653045015984 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045015985 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 653045015986 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 653045015987 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045015988 phosphate binding site [ion binding]; other site 653045015989 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 653045015990 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045015991 active site 653045015992 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045015993 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045015994 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045015995 polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813 653045015996 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 653045015997 putative NADP binding site [chemical binding]; other site 653045015998 active site 653045015999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045016000 salt bridge; other site 653045016001 non-specific DNA binding site [nucleotide binding]; other site 653045016002 sequence-specific DNA binding site [nucleotide binding]; other site 653045016003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016004 NAD(P) binding site [chemical binding]; other site 653045016005 active site 653045016006 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016007 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045016008 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 653045016009 Zn binding site [ion binding]; other site 653045016010 AMP-binding enzyme; Region: AMP-binding; cl15778 653045016011 L-aminoadipate-semialdehyde dehydrogenase; Region: alpha_am_amid; TIGR03443 653045016012 non-ribosomal peptide synthetase terminal domain of unknown function; Region: NRPS_term_dom; TIGR02353 653045016013 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 653045016014 putative CoA binding site [chemical binding]; other site 653045016015 putative trimer interface [polypeptide binding]; other site 653045016016 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 653045016017 putative trimer interface [polypeptide binding]; other site 653045016018 putative CoA binding site [chemical binding]; other site 653045016019 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 653045016020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016021 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045016022 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016023 NAD(P) binding site [chemical binding]; other site 653045016024 active site 653045016025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016026 Epoxide hydrolase N terminus; Region: EHN; pfam06441 653045016027 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045016028 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 653045016029 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045016030 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045016031 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045016032 active site 653045016033 ATP binding site [chemical binding]; other site 653045016034 substrate binding site [chemical binding]; other site 653045016035 activation loop (A-loop); other site 653045016036 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045016037 structural tetrad; other site 653045016038 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045016039 structural tetrad; other site 653045016040 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045016041 phosphopeptide binding site; other site 653045016042 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045016043 active site 653045016044 ATP binding site [chemical binding]; other site 653045016045 substrate binding site [chemical binding]; other site 653045016046 activation loop (A-loop); other site 653045016047 Peptidase family M48; Region: Peptidase_M48; cl12018 653045016048 Helix-turn-helix domains; Region: HTH; cl00088 653045016049 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045016050 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 653045016051 putative ADP-binding pocket [chemical binding]; other site 653045016052 Bacitracin resistance protein BacA; Region: BacA; cl00858 653045016053 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 653045016054 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 653045016055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045016056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045016057 active site 653045016058 phosphorylation site [posttranslational modification] 653045016059 intermolecular recognition site; other site 653045016060 dimerization interface [polypeptide binding]; other site 653045016061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045016062 DNA binding site [nucleotide binding] 653045016063 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045016064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045016065 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045016066 dimer interface [polypeptide binding]; other site 653045016067 phosphorylation site [posttranslational modification] 653045016068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045016069 ATP binding site [chemical binding]; other site 653045016070 Mg2+ binding site [ion binding]; other site 653045016071 G-X-G motif; other site 653045016072 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705 653045016073 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045016074 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045016075 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045016076 Repeat of Unknown Function (DUF347); Region: DUF347; pfam03988 653045016077 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 653045016078 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045016079 dimer interface [polypeptide binding]; other site 653045016080 phosphorylation site [posttranslational modification] 653045016081 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045016082 ATP binding site [chemical binding]; other site 653045016083 Mg2+ binding site [ion binding]; other site 653045016084 G-X-G motif; other site 653045016085 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045016086 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045016087 active site 653045016088 phosphorylation site [posttranslational modification] 653045016089 intermolecular recognition site; other site 653045016090 dimerization interface [polypeptide binding]; other site 653045016091 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045016092 DNA binding site [nucleotide binding] 653045016093 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 653045016094 active site 653045016095 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045016096 Helix-turn-helix domains; Region: HTH; cl00088 653045016097 Peptidase family M48; Region: Peptidase_M48; cl12018 653045016098 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 653045016099 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045016100 Uncharacterized conserved protein [Function unknown]; Region: COG2128 653045016101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045016102 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045016103 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 653045016104 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045016105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045016106 catalytic residue [active] 653045016107 Cupin domain; Region: Cupin_2; cl09118 653045016108 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 653045016109 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045016110 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045016111 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 653045016112 active site 653045016113 catalytic tetrad [active] 653045016114 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cd00413 653045016115 active site 653045016116 catalytic residues [active] 653045016117 Helix-turn-helix domains; Region: HTH; cl00088 653045016118 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045016119 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045016120 putative NAD(P) binding site [chemical binding]; other site 653045016121 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016122 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045016123 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045016124 Integrase core domain; Region: rve; cl01316 653045016125 Integrase core domain; Region: rve_3; cl15866 653045016126 Integrase core domain; Region: rve; cl01316 653045016127 Integrase core domain; Region: rve_3; cl15866 653045016128 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 653045016129 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 653045016130 putative active site [active] 653045016131 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045016132 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045016133 active site 653045016134 ATP binding site [chemical binding]; other site 653045016135 substrate binding site [chemical binding]; other site 653045016136 activation loop (A-loop); other site 653045016137 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045016138 active site 653045016139 ATP binding site [chemical binding]; other site 653045016140 substrate binding site [chemical binding]; other site 653045016141 activation loop (A-loop); other site 653045016142 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045016143 Trp docking motif [polypeptide binding]; other site 653045016144 PQQ-like domain; Region: PQQ_2; pfam13360 653045016145 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 653045016146 Trp docking motif [polypeptide binding]; other site 653045016147 active site 653045016148 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045016149 Integrase core domain; Region: rve; cl01316 653045016150 Integrase core domain; Region: rve_3; cl15866 653045016151 Helix-turn-helix domains; Region: HTH; cl00088 653045016152 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 653045016153 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045016154 Epoxide hydrolase N terminus; Region: EHN; pfam06441 653045016155 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045016156 Transposase domain (DUF772); Region: DUF772; pfam05598 653045016157 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016158 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045016159 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045016160 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016161 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016162 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 653045016163 DNA binding residues [nucleotide binding] 653045016164 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045016165 drug binding residues [chemical binding]; other site 653045016166 dimer interface [polypeptide binding]; other site 653045016167 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 653045016168 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045016169 Protein of unknown function, DUF393; Region: DUF393; cl01136 653045016170 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016171 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045016172 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016173 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045016174 NAD(P) binding site [chemical binding]; other site 653045016175 active site 653045016176 Competence protein CoiA-like family; Region: CoiA; cl11541 653045016177 Integrase core domain; Region: rve; cl01316 653045016178 Integrase core domain; Region: rve_3; cl15866 653045016179 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045016180 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045016181 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045016182 Integrase core domain; Region: rve; cl01316 653045016183 Integrase core domain; Region: rve_3; cl15866 653045016184 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045016185 Helix-turn-helix domains; Region: HTH; cl00088 653045016186 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 653045016187 putative hydrophobic ligand binding site [chemical binding]; other site 653045016188 Integrase core domain; Region: rve; cl01316 653045016189 Integrase core domain; Region: rve_3; cl15866 653045016190 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045016191 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045016192 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045016193 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045016194 active site 653045016195 metal binding site [ion binding]; metal-binding site 653045016196 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045016197 Helix-turn-helix domains; Region: HTH; cl00088 653045016198 Helix-turn-helix domains; Region: HTH; cl00088 653045016199 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 653045016200 Rhodopirellula transposase DDE domain; Region: DDE_Tnp_ISAZ013; pfam07592 653045016201 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045016202 MULE transposase domain; Region: MULE; pfam10551 653045016203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045016204 putative substrate translocation pore; other site 653045016205 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016206 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045016207 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 653045016208 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045016209 DNA-binding site [nucleotide binding]; DNA binding site 653045016210 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045016211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045016212 homodimer interface [polypeptide binding]; other site 653045016213 catalytic residue [active] 653045016214 transaminase; Validated; Region: PRK07324 653045016215 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045016216 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045016217 homodimer interface [polypeptide binding]; other site 653045016218 catalytic residue [active] 653045016219 Putative cyclase; Region: Cyclase; cl00814 653045016220 DDE superfamily endonuclease; Region: DDE_5; cl02413 653045016221 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 653045016222 Helix-turn-helix domains; Region: HTH; cl00088 653045016223 Helix-turn-helix domains; Region: HTH; cl00088 653045016224 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 653045016225 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045016226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016227 NAD(P) binding site [chemical binding]; other site 653045016228 active site 653045016229 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045016230 classical (c) SDRs; Region: SDR_c; cd05233 653045016231 NAD(P) binding site [chemical binding]; other site 653045016232 active site 653045016233 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016235 hypothetical protein; Provisional; Region: PRK07588 653045016236 Helix-turn-helix domains; Region: HTH; cl00088 653045016237 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 653045016238 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016239 NAD(P) binding site [chemical binding]; other site 653045016240 active site 653045016241 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045016242 Helix-turn-helix domains; Region: HTH; cl00088 653045016243 uridine kinase; Validated; Region: PRK06696 653045016244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045016245 active site 653045016246 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 653045016247 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 653045016248 DNA-binding interface [nucleotide binding]; DNA binding site 653045016249 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045016250 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016251 NAD(P) binding site [chemical binding]; other site 653045016252 active site 653045016253 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 653045016254 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 653045016255 DNA binding residues [nucleotide binding] 653045016256 putative dimer interface [polypeptide binding]; other site 653045016257 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 653045016258 Helix-turn-helix domains; Region: HTH; cl00088 653045016259 Integrase core domain; Region: rve; cl01316 653045016260 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 653045016261 catalytic residues [active] 653045016262 catalytic nucleophile [active] 653045016263 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045016264 MULE transposase domain; Region: MULE; pfam10551 653045016265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045016266 Integrase core domain; Region: rve; cl01316 653045016267 Integrase core domain; Region: rve_3; cl15866 653045016268 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045016269 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045016270 active site 653045016271 metal binding site [ion binding]; metal-binding site 653045016272 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045016273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045016274 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045016275 classical (c) SDRs; Region: SDR_c; cd05233 653045016276 NAD(P) binding site [chemical binding]; other site 653045016277 active site 653045016278 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045016279 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 653045016280 NADP binding site [chemical binding]; other site 653045016281 dimer interface [polypeptide binding]; other site 653045016282 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045016283 Helix-turn-helix domains; Region: HTH; cl00088 653045016284 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045016285 Helix-turn-helix domains; Region: HTH; cl00088 653045016286 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045016287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045016288 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045016289 Domain of unknown function (DUF3471); Region: DUF3471; pfam11954 653045016290 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 653045016291 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 653045016292 active site 653045016293 dimer interface [polypeptide binding]; other site 653045016294 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016295 ornithine cyclodeaminase; Validated; Region: PRK06141 653045016296 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016297 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045016298 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045016300 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045016301 Integrase core domain; Region: rve; cl01316 653045016302 Integrase core domain; Region: rve_3; cl15866 653045016303 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045016304 non-specific DNA binding site [nucleotide binding]; other site 653045016305 salt bridge; other site 653045016306 sequence-specific DNA binding site [nucleotide binding]; other site 653045016307 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 653045016308 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 653045016309 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045016310 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 653045016311 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045016312 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016313 NAD(P) binding site [chemical binding]; other site 653045016314 active site 653045016315 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045016316 Helix-turn-helix domains; Region: HTH; cl00088 653045016317 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_1; cd08460 653045016318 putative substrate binding pocket [chemical binding]; other site 653045016319 putative dimerization interface [polypeptide binding]; other site 653045016320 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 653045016321 active site 653045016322 Winged helix-turn helix; Region: HTH_29; pfam13551 653045016323 Helix-turn-helix domains; Region: HTH; cl00088 653045016324 Winged helix-turn helix; Region: HTH_33; pfam13592 653045016325 Integrase core domain; Region: rve; cl01316 653045016326 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 653045016327 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045016328 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 653045016329 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 653045016330 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 653045016331 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 653045016332 putative DNA binding site [nucleotide binding]; other site 653045016333 putative homodimer interface [polypeptide binding]; other site 653045016334 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045016335 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045016336 DNA binding residues [nucleotide binding] 653045016337 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045016338 Cupin domain; Region: Cupin_2; cl09118 653045016339 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045016340 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045016341 active site 653045016342 catalytic tetrad [active] 653045016343 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045016344 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 653045016345 Helix-turn-helix domains; Region: HTH; cl00088 653045016346 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045016347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045016348 active site 653045016349 metal binding site [ion binding]; metal-binding site 653045016350 Cupin domain; Region: Cupin_2; cl09118 653045016351 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045016352 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 653045016353 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045016354 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045016355 active site 653045016356 catalytic tetrad [active] 653045016357 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016358 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 653045016359 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 653045016360 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016361 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045016362 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 653045016363 catalytic triad [active] 653045016364 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016365 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045016366 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045016367 Helix-turn-helix domains; Region: HTH; cl00088 653045016368 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016369 Helix-turn-helix domains; Region: HTH; cl00088 653045016370 Predicted transcriptional regulator [Transcription]; Region: COG2378 653045016371 WYL domain; Region: WYL; cl14852 653045016372 Uncharacterized conserved protein [Function unknown]; Region: COG3268 653045016373 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016374 NAD(P) binding site [chemical binding]; other site 653045016375 Integrase core domain; Region: rve_3; cl15866 653045016376 Integrase core domain; Region: rve; cl01316 653045016377 Integrase core domain; Region: rve_3; cl15866 653045016378 RHS Repeat; Region: RHS_repeat; cl11982 653045016379 RHS Repeat; Region: RHS_repeat; cl11982 653045016380 RHS Repeat; Region: RHS_repeat; cl11982 653045016381 RHS Repeat; Region: RHS_repeat; cl11982 653045016382 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 653045016383 RHS Repeat; Region: RHS_repeat; cl11982 653045016384 RHS Repeat; Region: RHS_repeat; cl11982 653045016385 RHS Repeat; Region: RHS_repeat; cl11982 653045016386 RHS Repeat; Region: RHS_repeat; cl11982 653045016387 RHS Repeat; Region: RHS_repeat; cl11982 653045016388 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 653045016389 DDE superfamily endonuclease; Region: DDE_5; cl02413 653045016390 Winged helix-turn helix; Region: HTH_29; pfam13551 653045016391 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045016392 Integrase core domain; Region: rve; cl01316 653045016393 Integrase core domain; Region: rve_3; cl15866 653045016394 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016395 Helix-turn-helix domains; Region: HTH; cl00088 653045016396 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045016397 Helix-turn-helix domains; Region: HTH; cl00088 653045016398 Winged helix-turn helix; Region: HTH_29; pfam13551 653045016399 Helix-turn-helix domains; Region: HTH; cl00088 653045016400 Predicted ATPase [General function prediction only]; Region: COG3899 653045016401 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045016402 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045016403 DNA binding residues [nucleotide binding] 653045016404 dimerization interface [polypeptide binding]; other site 653045016405 potential frameshift: common BLAST hit: gi|302866943|ref|YP_003835580.1| beta-ketoacyl synthase 653045016406 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016407 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016408 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016409 putative NADP binding site [chemical binding]; other site 653045016410 active site 653045016411 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016412 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016413 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016414 active site 653045016415 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016416 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016417 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016418 putative NADP binding site [chemical binding]; other site 653045016419 active site 653045016420 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016421 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016422 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045016423 active site 653045016424 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016425 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045016426 NADP binding site [chemical binding]; other site 653045016427 active site 653045016428 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016429 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016430 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016431 active site 653045016432 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016433 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016434 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016435 putative NADP binding site [chemical binding]; other site 653045016436 active site 653045016437 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016438 Thioesterase; Region: PKS_TE; smart00824 653045016439 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016440 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045016441 active site 653045016442 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016443 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016444 active site 653045016445 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016446 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016447 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016448 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016449 active site 653045016450 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016451 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016452 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016453 putative NADP binding site [chemical binding]; other site 653045016454 active site 653045016455 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016456 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016457 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016458 active site 653045016459 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016460 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016461 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016462 putative NADP binding site [chemical binding]; other site 653045016463 active site 653045016464 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016465 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016466 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016467 active site 653045016468 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016469 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016470 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016471 putative NADP binding site [chemical binding]; other site 653045016472 active site 653045016473 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016474 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016475 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045016476 substrate binding pocket [chemical binding]; other site 653045016477 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016478 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 653045016479 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 653045016480 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 653045016481 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 653045016482 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 653045016483 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 653045016484 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 653045016485 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016486 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 653045016487 classical (c) SDRs; Region: SDR_c; cd05233 653045016488 NAD(P) binding site [chemical binding]; other site 653045016489 active site 653045016490 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 653045016491 NAD binding site [chemical binding]; other site 653045016492 catalytic residues [active] 653045016493 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 653045016494 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 653045016495 catalytic Zn binding site [ion binding]; other site 653045016496 NAD binding site [chemical binding]; other site 653045016497 structural Zn binding site [ion binding]; other site 653045016498 Erythronolide synthase docking; Region: Docking; pfam08990 653045016499 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016500 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016501 active site 653045016502 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016503 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016504 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016505 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045016506 Enoylreductase; Region: PKS_ER; smart00829 653045016507 NAD(P) binding site [chemical binding]; other site 653045016508 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016509 putative NADP binding site [chemical binding]; other site 653045016510 active site 653045016511 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016512 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016513 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016514 active site 653045016515 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016516 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045016517 NADP binding site [chemical binding]; other site 653045016518 active site 653045016519 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016520 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016521 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045016522 active site 653045016523 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045016524 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016525 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045016526 NADP binding site [chemical binding]; other site 653045016527 active site 653045016528 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016529 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045016530 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016531 active site 653045016532 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016533 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045016534 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016535 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045016536 Enoylreductase; Region: PKS_ER; smart00829 653045016537 NAD(P) binding site [chemical binding]; other site 653045016538 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045016539 putative NADP binding site [chemical binding]; other site 653045016540 active site 653045016541 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016542 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045016543 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045016544 active site 653045016545 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045016546 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045016547 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045016548 NADP binding site [chemical binding]; other site 653045016549 active site 653045016550 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045016551 Transposase domain (DUF772); Region: DUF772; pfam05598 653045016552 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016553 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016554 short chain dehydrogenase; Provisional; Region: PRK06482 653045016555 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045016556 NADP binding site [chemical binding]; other site 653045016557 active site 653045016558 steroid binding site; other site 653045016559 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016560 Carboxylesterase family; Region: COesterase; pfam00135 653045016561 substrate binding pocket [chemical binding]; other site 653045016562 catalytic triad [active] 653045016563 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045016564 catalytic site [active] 653045016565 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045016566 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045016567 DNA-binding site [nucleotide binding]; DNA binding site 653045016568 UTRA domain; Region: UTRA; cl01230 653045016569 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 653045016570 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 653045016571 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 653045016572 dimer interface [polypeptide binding]; other site 653045016573 active site 653045016574 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 653045016575 putative active site [active] 653045016576 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045016577 EamA-like transporter family; Region: EamA; cl01037 653045016578 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 653045016579 intersubunit interface [polypeptide binding]; other site 653045016580 active site 653045016581 zinc binding site [ion binding]; other site 653045016582 Na+ binding site [ion binding]; other site 653045016583 Winged helix-turn helix; Region: HTH_29; pfam13551 653045016584 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045016585 Integrase core domain; Region: rve; cl01316 653045016586 Integrase core domain; Region: rve_3; cl15866 653045016587 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045016588 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045016589 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 653045016590 NmrA-like family; Region: NmrA; pfam05368 653045016591 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 653045016592 NADP binding site [chemical binding]; other site 653045016593 active site 653045016594 regulatory binding site [polypeptide binding]; other site 653045016595 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045016596 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045016597 putative NAD(P) binding site [chemical binding]; other site 653045016598 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045016599 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016600 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045016601 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 653045016602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016603 NAD(P) binding site [chemical binding]; other site 653045016604 active site 653045016605 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045016606 salt bridge; other site 653045016607 non-specific DNA binding site [nucleotide binding]; other site 653045016608 sequence-specific DNA binding site [nucleotide binding]; other site 653045016609 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045016610 MULE transposase domain; Region: MULE; pfam10551 653045016611 Winged helix-turn helix; Region: HTH_29; pfam13551 653045016612 Transposase; Region: HTH_Tnp_Tc3_2; pfam01498 653045016613 Integrase core domain; Region: rve; cl01316 653045016614 Integrase core domain; Region: rve_3; cl15866 653045016615 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 653045016616 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 653045016617 PYR/PP interface [polypeptide binding]; other site 653045016618 dimer interface [polypeptide binding]; other site 653045016619 TPP binding site [chemical binding]; other site 653045016620 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 653045016621 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016622 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 653045016623 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 653045016624 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 653045016625 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 653045016626 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045016627 Amidohydrolase; Region: Amidohydro_4; pfam13147 653045016628 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045016629 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045016630 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045016631 Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257 653045016632 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 653045016633 intersubunit interface [polypeptide binding]; other site 653045016634 TROVE domain; Region: TROVE; pfam05731 653045016635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045016636 dimer interface [polypeptide binding]; other site 653045016637 conserved gate region; other site 653045016638 putative PBP binding loops; other site 653045016639 ABC-ATPase subunit interface; other site 653045016640 NMT1-like family; Region: NMT1_2; cl15260 653045016641 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 653045016642 NMT1-like family; Region: NMT1_2; cl15260 653045016643 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 653045016644 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 653045016645 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 653045016646 Walker A/P-loop; other site 653045016647 ATP binding site [chemical binding]; other site 653045016648 Q-loop/lid; other site 653045016649 ABC transporter signature motif; other site 653045016650 Walker B; other site 653045016651 D-loop; other site 653045016652 H-loop/switch region; other site 653045016653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 653045016654 5'-3' exonuclease; Region: 53EXOc; smart00475 653045016655 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 653045016656 active site 653045016657 metal binding site 1 [ion binding]; metal-binding site 653045016658 putative 5' ssDNA interaction site; other site 653045016659 metal binding site 3; metal-binding site 653045016660 metal binding site 2 [ion binding]; metal-binding site 653045016661 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 653045016662 putative DNA binding site [nucleotide binding]; other site 653045016663 putative metal binding site [ion binding]; other site 653045016664 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 653045016665 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 653045016666 FAD binding pocket [chemical binding]; other site 653045016667 FAD binding motif [chemical binding]; other site 653045016668 phosphate binding motif [ion binding]; other site 653045016669 NAD binding pocket [chemical binding]; other site 653045016670 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 653045016671 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 653045016672 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 653045016673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045016674 ATP binding site [chemical binding]; other site 653045016675 putative Mg++ binding site [ion binding]; other site 653045016676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045016677 nucleotide binding region [chemical binding]; other site 653045016678 ATP-binding site [chemical binding]; other site 653045016679 rRNA-processing arch domain; Region: rRNA_proc-arch; pfam13234 653045016680 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 653045016681 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 653045016682 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 653045016683 WYL domain; Region: WYL; cl14852 653045016684 Predicted transcriptional regulator [Transcription]; Region: COG2378 653045016685 WYL domain; Region: WYL; cl14852 653045016686 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 653045016687 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 653045016688 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 653045016689 Pup-ligase protein; Region: Pup_ligase; cl15463 653045016690 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045016691 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045016692 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045016693 DNA binding site [nucleotide binding] 653045016694 domain linker motif; other site 653045016695 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045016696 dimerization interface [polypeptide binding]; other site 653045016697 ligand binding site [chemical binding]; other site 653045016698 proteasome, alpha subunit, bacterial type; Region: 20S_bact_alpha; TIGR03691 653045016699 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 653045016700 active site 653045016701 20S proteasome, alpha and beta subunits [Posttranslational modification, protein turnover, chaperones]; Region: PRE1; COG0638 653045016702 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 653045016703 active site 653045016704 Pup-like protein; Region: Pup; cl05289 653045016705 Pup-ligase protein; Region: Pup_ligase; cl15463 653045016706 proteasome ATPase; Region: pup_AAA; TIGR03689 653045016707 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045016708 Walker A motif; other site 653045016709 ATP binding site [chemical binding]; other site 653045016710 Walker B motif; other site 653045016711 arginine finger; other site 653045016712 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045016713 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 653045016714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045016715 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 653045016716 active site 653045016717 putative substrate binding region [chemical binding]; other site 653045016718 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 653045016719 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 653045016720 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 653045016721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045016722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045016723 active site 653045016724 phosphorylation site [posttranslational modification] 653045016725 intermolecular recognition site; other site 653045016726 dimerization interface [polypeptide binding]; other site 653045016727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045016728 DNA binding residues [nucleotide binding] 653045016729 dimerization interface [polypeptide binding]; other site 653045016730 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 653045016731 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045016732 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 653045016733 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 653045016734 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 653045016735 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045016736 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045016737 motif II; other site 653045016738 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 653045016739 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 653045016740 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 653045016741 substrate binding pocket [chemical binding]; other site 653045016742 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 653045016743 B12 binding site [chemical binding]; other site 653045016744 cobalt ligand [ion binding]; other site 653045016745 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 653045016746 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045016747 Helix-turn-helix domains; Region: HTH; cl00088 653045016748 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045016749 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 653045016750 amphipathic channel; other site 653045016751 Asn-Pro-Ala signature motifs; other site 653045016752 glycerol kinase; Region: glycerol_kin; TIGR01311 653045016753 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 653045016754 N- and C-terminal domain interface [polypeptide binding]; other site 653045016755 putative active site [active] 653045016756 putative MgATP binding site [chemical binding]; other site 653045016757 catalytic site [active] 653045016758 metal binding site [ion binding]; metal-binding site 653045016759 putative homotetramer interface [polypeptide binding]; other site 653045016760 putative glycerol binding site [chemical binding]; other site 653045016761 homodimer interface [polypeptide binding]; other site 653045016762 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 653045016763 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045016764 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045016765 DNA-binding site [nucleotide binding]; DNA binding site 653045016766 FCD domain; Region: FCD; cl11656 653045016767 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 653045016768 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045016769 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045016770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045016771 active site 653045016772 catalytic tetrad [active] 653045016773 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045016774 TM-ABC transporter signature motif; other site 653045016775 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 653045016776 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045016777 Walker A/P-loop; other site 653045016778 ATP binding site [chemical binding]; other site 653045016779 Q-loop/lid; other site 653045016780 ABC transporter signature motif; other site 653045016781 Walker B; other site 653045016782 D-loop; other site 653045016783 H-loop/switch region; other site 653045016784 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 653045016785 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 653045016786 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 653045016787 ligand binding site [chemical binding]; other site 653045016788 classical (c) SDRs; Region: SDR_c; cd05233 653045016789 NAD(P) binding site [chemical binding]; other site 653045016790 active site 653045016791 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 653045016792 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045016793 metal binding site [ion binding]; metal-binding site 653045016794 substrate binding pocket [chemical binding]; other site 653045016795 PAC2 family; Region: PAC2; cl00847 653045016796 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045016797 cysteinyl-tRNA synthetase; Provisional; Region: PRK12418 653045016798 active site 653045016799 HIGH motif; other site 653045016800 nucleotide binding site [chemical binding]; other site 653045016801 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045016802 active site 653045016803 KMSKS motif; other site 653045016804 Anticodon-binding domain of cysteinyl tRNA synthetases and domain found in MshC; Region: Anticodon_Ia_Cys_like; cd07955 653045016805 putative tRNA binding surface [nucleotide binding]; other site 653045016806 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 653045016807 Protein of unknown function (DUF3090); Region: DUF3090; cl12832 653045016808 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045016809 catalytic core [active] 653045016810 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 653045016811 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 653045016812 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 653045016813 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 653045016814 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045016815 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045016816 active site 653045016817 catalytic tetrad [active] 653045016818 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 653045016819 Family description; Region: UvrD_C_2; cl15862 653045016820 Small secreted domain (DUF320); Region: DUF320; pfam03777 653045016821 Small secreted domain (DUF320); Region: DUF320; pfam03777 653045016822 hypothetical protein; Provisional; Region: PRK07906 653045016823 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 653045016824 putative metal binding site [ion binding]; other site 653045016825 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045016826 classical (c) SDRs; Region: SDR_c; cd05233 653045016827 NAD(P) binding site [chemical binding]; other site 653045016828 active site 653045016829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016830 short chain dehydrogenase; Provisional; Region: PRK06180 653045016831 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045016832 NADP binding site [chemical binding]; other site 653045016833 active site 653045016834 steroid binding site; other site 653045016835 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045016836 Helix-turn-helix domains; Region: HTH; cl00088 653045016837 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 653045016838 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 653045016839 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 653045016840 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045016841 K+-transporting ATPase, c chain; Region: KdpC; cl00944 653045016842 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045016843 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045016844 DNA binding residues [nucleotide binding] 653045016845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045016846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045016847 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045016848 Probable transposase; Region: OrfB_IS605; pfam01385 653045016849 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045016850 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016851 NAD(P) binding site [chemical binding]; other site 653045016852 active site 653045016853 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 653045016854 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045016855 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 653045016856 putative NAD(P) binding site [chemical binding]; other site 653045016857 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 653045016858 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 653045016859 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 653045016860 Creatinine amidohydrolase; Region: Creatininase; cl00618 653045016861 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 653045016862 GTP cyclohydrolase II [Coenzyme metabolism]; Region: RibA; COG0807 653045016863 dimerization interface [polypeptide binding]; other site 653045016864 active site 653045016865 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 653045016866 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045016867 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 653045016868 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 653045016869 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 653045016870 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045016871 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045016872 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045016873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016874 NAD(P) binding site [chemical binding]; other site 653045016875 active site 653045016876 PAS fold; Region: PAS_4; pfam08448 653045016877 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045016878 putative active site [active] 653045016879 heme pocket [chemical binding]; other site 653045016880 GAF domain; Region: GAF_2; pfam13185 653045016881 GAF domain; Region: GAF; cl15785 653045016882 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045016883 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045016884 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045016885 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 653045016886 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 653045016887 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 653045016888 DXD motif; other site 653045016889 cellulose synthase A; Region: PLN02195 653045016890 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 653045016891 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 653045016892 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 653045016893 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 653045016894 Moco binding site; other site 653045016895 metal coordination site [ion binding]; other site 653045016896 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 653045016897 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045016898 nudix motif; other site 653045016899 Domain of unknown function (DUF202); Region: DUF202; cl09954 653045016900 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045016901 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045016902 putative NAD(P) binding site [chemical binding]; other site 653045016903 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 653045016904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045016905 Helix-turn-helix domains; Region: HTH; cl00088 653045016906 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 653045016907 putative active site [active] 653045016908 putative substrate binding site [chemical binding]; other site 653045016909 ATP binding site [chemical binding]; other site 653045016910 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045016911 Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155 653045016912 FAD binding site [chemical binding]; other site 653045016913 substrate binding site [chemical binding]; other site 653045016914 catalytic base [active] 653045016915 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045016916 Helix-turn-helix domains; Region: HTH; cl00088 653045016917 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 653045016918 AMP-binding enzyme; Region: AMP-binding; cl15778 653045016919 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045016920 classical (c) SDRs; Region: SDR_c; cd05233 653045016921 NAD(P) binding site [chemical binding]; other site 653045016922 active site 653045016923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045016924 dimerization interface [polypeptide binding]; other site 653045016925 Penicillin amidase; Region: Penicil_amidase; pfam01804 653045016926 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 653045016927 active site 653045016928 NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit. Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450 653045016929 putative active site [active] 653045016930 putative catalytic site [active] 653045016931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045016932 Helix-turn-helix domains; Region: HTH; cl00088 653045016933 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 653045016934 homodimer interface [polypeptide binding]; other site 653045016935 substrate-cofactor binding pocket; other site 653045016936 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045016937 catalytic residue [active] 653045016938 Protein of unknown function (DUF402); Region: DUF402; cl00979 653045016939 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045016940 putative substrate translocation pore; other site 653045016941 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 653045016942 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 653045016943 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 653045016944 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 653045016945 molybdopterin cofactor binding site; other site 653045016946 The MopB_CT_1 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_1; cd02782 653045016947 putative molybdopterin cofactor binding site; other site 653045016948 Helix-turn-helix domains; Region: HTH; cl00088 653045016949 Cupin domain; Region: Cupin_2; cl09118 653045016950 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045016951 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045016952 DNA-binding site [nucleotide binding]; DNA binding site 653045016953 UTRA domain; Region: UTRA; cl01230 653045016954 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 653045016955 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 653045016956 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 653045016957 binding surface 653045016958 TPR motif; other site 653045016959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045016960 TPR motif; other site 653045016961 binding surface 653045016962 High-affinity nickel-transport protein; Region: NicO; cl00964 653045016963 SEST_like. A family of secreted SGNH-hydrolases similar to Streptomyces scabies esterase (SEST), a causal agent of the potato scab disease, which hydrolyzes a specific ester bond in suberin, a plant lipid. The tertiary fold of this enzyme is...; Region: SEST_like; cd01823 653045016964 active site 653045016965 oxyanion hole [active] 653045016966 catalytic triad [active] 653045016967 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 653045016968 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045016969 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 653045016970 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 653045016971 Ligand binding site; other site 653045016972 Putative Catalytic site; other site 653045016973 DXD motif; other site 653045016974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045016975 active site 653045016976 envelope glycoprotein C; Provisional; Region: PHA03269 653045016977 Domain of unknown function (DUF3432); Region: DUF3432; pfam11914 653045016978 outer membrane N-deacetylase; Provisional; Region: hmsF; PRK14581 653045016979 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 653045016980 putative active site [active] 653045016981 putative metal binding site [ion binding]; other site 653045016982 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 653045016983 MatE; Region: MatE; cl10513 653045016984 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045016985 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 653045016986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045016987 Walker A motif; other site 653045016988 ATP binding site [chemical binding]; other site 653045016989 Walker B motif; other site 653045016990 arginine finger; other site 653045016991 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 653045016992 Amidinotransferase; Region: Amidinotransf; cl12043 653045016993 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045016994 DNA-binding site [nucleotide binding]; DNA binding site 653045016995 Helix-turn-helix domains; Region: HTH; cl00088 653045016996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045016997 S-adenosylmethionine binding site [chemical binding]; other site 653045016998 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 653045016999 nudix motif; other site 653045017000 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 653045017001 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045017002 S-adenosylmethionine binding site [chemical binding]; other site 653045017003 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045017004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045017005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017006 hypothetical protein; Provisional; Region: PRK07588 653045017007 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045017008 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045017009 active site 653045017010 phosphorylation site [posttranslational modification] 653045017011 intermolecular recognition site; other site 653045017012 dimerization interface [polypeptide binding]; other site 653045017013 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045017014 DNA binding residues [nucleotide binding] 653045017015 dimerization interface [polypeptide binding]; other site 653045017016 Histidine kinase; Region: HisKA_3; pfam07730 653045017017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045017018 ATP binding site [chemical binding]; other site 653045017019 Mg2+ binding site [ion binding]; other site 653045017020 G-X-G motif; other site 653045017021 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045017022 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045017023 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045017024 active site 653045017025 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045017026 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045017027 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045017028 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045017029 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045017030 active site 653045017031 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045017032 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045017033 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045017034 putative NADP binding site [chemical binding]; other site 653045017035 active site 653045017036 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045017037 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045017038 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045017039 active site 653045017040 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045017041 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045017042 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045017043 NADP binding site [chemical binding]; other site 653045017044 active site 653045017045 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045017046 Thioesterase; Region: PKS_TE; smart00824 653045017047 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045017048 O-methyltransferase; Region: Methyltransf_3; pfam01596 653045017049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045017050 S-adenosylmethionine binding site [chemical binding]; other site 653045017051 FkbH-like domain; Region: FkbH; TIGR01686 653045017052 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045017053 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045017054 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045017055 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 653045017056 active site 653045017057 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045017058 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 653045017059 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017060 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 653045017061 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045017062 Helix-turn-helix domains; Region: HTH; cl00088 653045017063 short chain dehydrogenase; Provisional; Region: PRK06197 653045017064 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 653045017065 putative NAD(P) binding site [chemical binding]; other site 653045017066 active site 653045017067 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 653045017068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045017069 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045017070 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045017071 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045017072 putative active site [active] 653045017073 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045017074 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045017075 active site 653045017076 catalytic tetrad [active] 653045017077 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045017078 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045017079 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045017080 Probable transposase; Region: OrfB_IS605; pfam01385 653045017081 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045017082 Helix-turn-helix domain; Region: HTH_18; pfam12833 653045017083 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045017084 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 653045017085 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme PvsE; Region: PLPDE_III_PvsE_like; cd06843 653045017086 dimer interface [polypeptide binding]; other site 653045017087 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 653045017088 active site 653045017089 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045017090 catalytic residues [active] 653045017091 substrate binding site [chemical binding]; other site 653045017092 IucA / IucC family; Region: IucA_IucC; pfam04183 653045017093 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 653045017094 IucA / IucC family; Region: IucA_IucC; pfam04183 653045017095 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 653045017096 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045017097 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045017098 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045017099 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045017100 Chitin binding domain; Region: Chitin_bind_3; cl03871 653045017101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045017102 Helix-turn-helix domains; Region: HTH; cl00088 653045017103 OsmC-like protein; Region: OsmC; cl00767 653045017104 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045017105 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 653045017106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017107 Y-family of DNA polymerases; Region: PolY; cl12025 653045017108 DNA binding site [nucleotide binding] 653045017109 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 653045017110 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 653045017111 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 653045017112 generic binding surface II; other site 653045017113 generic binding surface I; other site 653045017114 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045017115 Subtilisin inhibitor-like; Region: SSI; cl11594 653045017116 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045017117 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045017118 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 653045017119 Alpha-lytic protease prodomain; Region: Pro_Al_protease; pfam02983 653045017120 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045017121 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 653045017122 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 653045017123 active site 653045017124 non-prolyl cis peptide bond; other site 653045017125 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 653045017126 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045017127 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045017128 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045017129 substrate binding pocket [chemical binding]; other site 653045017130 membrane-bound complex binding site; other site 653045017131 hinge residues; other site 653045017132 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 653045017133 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 653045017134 Walker A/P-loop; other site 653045017135 ATP binding site [chemical binding]; other site 653045017136 Q-loop/lid; other site 653045017137 ABC transporter signature motif; other site 653045017138 Walker B; other site 653045017139 D-loop; other site 653045017140 H-loop/switch region; other site 653045017141 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 653045017142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045017143 dimer interface [polypeptide binding]; other site 653045017144 conserved gate region; other site 653045017145 putative PBP binding loops; other site 653045017146 ABC-ATPase subunit interface; other site 653045017147 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017148 Protein of unknown function (DUF552); Region: DUF552; cl00775 653045017149 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045017150 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045017151 active site 653045017152 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 653045017153 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045017154 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045017155 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 653045017156 active site 653045017157 Potato inhibitor I family; Region: potato_inhibit; cl15459 653045017158 Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800 653045017159 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045017160 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 653045017161 Gas vesicle protein G; Region: GvpG; pfam05120 653045017162 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045017163 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 653045017164 Gas vesicle protein; Region: Gas_vesicle; cl02954 653045017165 Gas vesicle protein K; Region: GvpK; pfam05121 653045017166 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 653045017167 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 653045017168 D-pathway; other site 653045017169 Putative ubiquinol binding site [chemical binding]; other site 653045017170 Low-spin heme (heme b) binding site [chemical binding]; other site 653045017171 Putative water exit pathway; other site 653045017172 Binuclear center (heme o3/CuB) [ion binding]; other site 653045017173 K-pathway; other site 653045017174 Putative proton exit pathway; other site 653045017175 WYL domain; Region: WYL; cl14852 653045017176 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045017177 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 653045017178 putative ADP-binding pocket [chemical binding]; other site 653045017179 GTP-binding protein Der; Reviewed; Region: PRK03003 653045017180 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 653045017181 G1 box; other site 653045017182 GTP/Mg2+ binding site [chemical binding]; other site 653045017183 Switch I region; other site 653045017184 G2 box; other site 653045017185 Switch II region; other site 653045017186 G3 box; other site 653045017187 G4 box; other site 653045017188 G5 box; other site 653045017189 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 653045017190 G1 box; other site 653045017191 GTP/Mg2+ binding site [chemical binding]; other site 653045017192 Switch I region; other site 653045017193 G2 box; other site 653045017194 G3 box; other site 653045017195 Switch II region; other site 653045017196 G4 box; other site 653045017197 G5 box; other site 653045017198 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 653045017199 putative acyl-acceptor binding pocket; other site 653045017200 cytidylate kinase; Provisional; Region: cmk; PRK00023 653045017201 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 653045017202 CMP-binding site; other site 653045017203 The sites determining sugar specificity; other site 653045017204 prephenate dehydrogenase; Validated; Region: PRK06545 653045017205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017206 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 653045017207 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 653045017208 homotrimer interaction site [polypeptide binding]; other site 653045017209 active site 653045017210 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 653045017211 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 653045017212 RNA binding surface [nucleotide binding]; other site 653045017213 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 653045017214 active site 653045017215 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 653045017216 ScpA/B protein; Region: ScpA_ScpB; cl00598 653045017217 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 653045017218 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 653045017219 P-loop; other site 653045017220 Magnesium ion binding site [ion binding]; other site 653045017221 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 653045017222 Magnesium ion binding site [ion binding]; other site 653045017223 alanine dehydrogenase; Region: alaDH; TIGR00518 653045017224 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 653045017225 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017226 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 653045017227 dimer interface [polypeptide binding]; other site 653045017228 ADP-ribose binding site [chemical binding]; other site 653045017229 active site 653045017230 nudix motif; other site 653045017231 metal binding site [ion binding]; metal-binding site 653045017232 CTP synthetase; Validated; Region: pyrG; PRK05380 653045017233 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 653045017234 Catalytic site [active] 653045017235 active site 653045017236 UTP binding site [chemical binding]; other site 653045017237 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 653045017238 active site 653045017239 putative oxyanion hole; other site 653045017240 catalytic triad [active] 653045017241 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 653045017242 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 653045017243 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 653045017244 Helix-turn-helix domains; Region: HTH; cl00088 653045017245 glycoside hydrolase family 64: laminaripentaose-producing, beta-1,3-glucanase (LPHase)-like; Region: GH64-LPHase-like; cd09216 653045017246 substrate binding pocket [chemical binding]; other site 653045017247 catalytic residues [active] 653045017248 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045017249 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 653045017250 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 653045017251 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 653045017252 Walker A/P-loop; other site 653045017253 ATP binding site [chemical binding]; other site 653045017254 Q-loop/lid; other site 653045017255 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 653045017256 ABC transporter signature motif; other site 653045017257 Walker B; other site 653045017258 D-loop; other site 653045017259 H-loop/switch region; other site 653045017260 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 653045017261 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 653045017262 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 653045017263 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 653045017264 RNA binding surface [nucleotide binding]; other site 653045017265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045017266 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 653045017267 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 653045017268 Walker A/P-loop; other site 653045017269 ATP binding site [chemical binding]; other site 653045017270 Q-loop/lid; other site 653045017271 ABC transporter signature motif; other site 653045017272 Walker B; other site 653045017273 D-loop; other site 653045017274 H-loop/switch region; other site 653045017275 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 653045017276 ABC-ATPase subunit interface; other site 653045017277 dimer interface [polypeptide binding]; other site 653045017278 putative PBP binding regions; other site 653045017279 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 653045017280 ABC-ATPase subunit interface; other site 653045017281 dimer interface [polypeptide binding]; other site 653045017282 putative PBP binding regions; other site 653045017283 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 653045017284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045017285 active site 653045017286 motif I; other site 653045017287 motif II; other site 653045017288 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045017289 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 653045017290 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 653045017291 active site 653045017292 DNA binding site [nucleotide binding] 653045017293 SpoOM protein; Region: Spo0M; pfam07070 653045017294 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 653045017295 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 653045017296 putative RNAase interaction site [polypeptide binding]; other site 653045017297 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 653045017298 substrate binding site [chemical binding]; other site 653045017299 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 653045017300 active site 653045017301 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 653045017302 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 653045017303 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 653045017304 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 653045017305 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 653045017306 Walker A/P-loop; other site 653045017307 ATP binding site [chemical binding]; other site 653045017308 Q-loop/lid; other site 653045017309 ABC transporter signature motif; other site 653045017310 Walker B; other site 653045017311 D-loop; other site 653045017312 H-loop/switch region; other site 653045017313 Small secreted domain (DUF320); Region: DUF320; pfam03777 653045017314 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045017315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045017316 active site 653045017317 phosphorylation site [posttranslational modification] 653045017318 intermolecular recognition site; other site 653045017319 dimerization interface [polypeptide binding]; other site 653045017320 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045017321 DNA binding residues [nucleotide binding] 653045017322 dimerization interface [polypeptide binding]; other site 653045017323 GAF domain; Region: GAF_2; pfam13185 653045017324 GAF domain; Region: GAF; cl15785 653045017325 Histidine kinase; Region: HisKA_3; pfam07730 653045017326 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045017327 ATP binding site [chemical binding]; other site 653045017328 Mg2+ binding site [ion binding]; other site 653045017329 G-X-G motif; other site 653045017330 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 653045017331 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045017332 phosphopeptide binding site; other site 653045017333 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045017334 phosphopeptide binding site; other site 653045017335 ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213 653045017336 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045017337 Walker A/P-loop; other site 653045017338 ATP binding site [chemical binding]; other site 653045017339 Q-loop/lid; other site 653045017340 ABC transporter signature motif; other site 653045017341 Walker B; other site 653045017342 D-loop; other site 653045017343 H-loop/switch region; other site 653045017344 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045017345 CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870 653045017346 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 653045017347 phosphoserine phosphatase SerB; Region: serB; TIGR00338 653045017348 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045017349 motif II; other site 653045017350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045017351 catalytic core [active] 653045017352 cyanate transporter; Region: CynX; TIGR00896 653045017353 cyanate transporter; Region: CynX; TIGR00896 653045017354 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045017355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045017356 DNA-binding site [nucleotide binding]; DNA binding site 653045017357 FCD domain; Region: FCD; cl11656 653045017358 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 653045017359 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 653045017360 NAD binding site [chemical binding]; other site 653045017361 homotetramer interface [polypeptide binding]; other site 653045017362 homodimer interface [polypeptide binding]; other site 653045017363 substrate binding site [chemical binding]; other site 653045017364 active site 653045017365 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 653045017366 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 653045017367 NAD(P) binding site [chemical binding]; other site 653045017368 homotetramer interface [polypeptide binding]; other site 653045017369 homodimer interface [polypeptide binding]; other site 653045017370 active site 653045017371 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 653045017372 NmrA-like family; Region: NmrA; pfam05368 653045017373 NADP binding site [chemical binding]; other site 653045017374 active site 653045017375 regulatory binding site [polypeptide binding]; other site 653045017376 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 653045017377 FMN binding site [chemical binding]; other site 653045017378 active site 653045017379 substrate binding site [chemical binding]; other site 653045017380 catalytic residue [active] 653045017381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045017382 Helix-turn-helix domains; Region: HTH; cl00088 653045017383 Helix-turn-helix domains; Region: HTH; cl00088 653045017384 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 653045017385 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 653045017386 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 653045017387 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 653045017388 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 653045017389 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045017390 active site 653045017391 nucleotide binding site [chemical binding]; other site 653045017392 HIGH motif; other site 653045017393 KMSKS motif; other site 653045017394 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 653045017395 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 653045017396 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 653045017397 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045017398 FeS/SAM binding site; other site 653045017399 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 653045017400 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 653045017401 Sodium:solute symporter family; Region: SSF; cl00456 653045017402 Protein of unknown function, DUF485; Region: DUF485; cl01231 653045017403 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 653045017404 active site 653045017405 catalytic residues [active] 653045017406 trigger factor; Provisional; Region: tig; PRK01490 653045017407 YhhN-like protein; Region: YhhN; cl01505 653045017408 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 653045017409 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 653045017410 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 653045017411 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 653045017412 active site 653045017413 catalytic site [active] 653045017414 substrate binding site [chemical binding]; other site 653045017415 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cl00038 653045017416 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 653045017417 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 653045017418 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 653045017419 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045017420 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017421 NAD(P) binding site [chemical binding]; other site 653045017422 active site 653045017423 Asp23 family; Region: Asp23; cl00574 653045017424 Response regulator receiver domain; Region: Response_reg; pfam00072 653045017425 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045017426 active site 653045017427 phosphorylation site [posttranslational modification] 653045017428 intermolecular recognition site; other site 653045017429 dimerization interface [polypeptide binding]; other site 653045017430 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045017431 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 653045017432 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045017433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045017434 dimerization interface [polypeptide binding]; other site 653045017435 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045017436 dimerization interface [polypeptide binding]; other site 653045017437 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045017438 dimerization interface [polypeptide binding]; other site 653045017439 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045017440 dimerization interface [polypeptide binding]; other site 653045017441 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045017442 GAF domain; Region: GAF_2; pfam13185 653045017443 GAF domain; Region: GAF; cl15785 653045017444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 653045017445 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045017446 ATP binding site [chemical binding]; other site 653045017447 Mg2+ binding site [ion binding]; other site 653045017448 G-X-G motif; other site 653045017449 Response regulator receiver domain; Region: Response_reg; pfam00072 653045017450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045017451 active site 653045017452 phosphorylation site [posttranslational modification] 653045017453 intermolecular recognition site; other site 653045017454 dimerization interface [polypeptide binding]; other site 653045017455 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045017456 GAF domain; Region: GAF; cl15785 653045017457 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045017458 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045017459 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045017460 substrate binding site [chemical binding]; other site 653045017461 oxyanion hole (OAH) forming residues; other site 653045017462 trimer interface [polypeptide binding]; other site 653045017463 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 653045017464 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017465 Walker A/P-loop; other site 653045017466 ATP binding site [chemical binding]; other site 653045017467 Q-loop/lid; other site 653045017468 ABC transporter signature motif; other site 653045017469 Walker B; other site 653045017470 D-loop; other site 653045017471 H-loop/switch region; other site 653045017472 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 653045017473 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 653045017474 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 653045017475 intersubunit interface [polypeptide binding]; other site 653045017476 active site 653045017477 Zn2+ binding site [ion binding]; other site 653045017478 Phosphate transporter family; Region: PHO4; cl00396 653045017479 CobD/Cbib protein; Region: CobD_Cbib; cl00561 653045017480 cobyric acid synthase; Provisional; Region: PRK00784 653045017481 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017482 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 653045017483 catalytic triad [active] 653045017484 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 653045017485 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017486 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 653045017487 metal ion-dependent adhesion site (MIDAS); other site 653045017488 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 653045017489 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 653045017490 homodimer interface [polypeptide binding]; other site 653045017491 Walker A motif; other site 653045017492 ATP binding site [chemical binding]; other site 653045017493 hydroxycobalamin binding site [chemical binding]; other site 653045017494 Walker B motif; other site 653045017495 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 653045017496 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017497 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 653045017498 catalytic triad [active] 653045017499 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 653045017500 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 653045017501 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 653045017502 putative active site [active] 653045017503 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 653045017504 putative active site [active] 653045017505 hypothetical protein; Provisional; Region: PRK07908 653045017506 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045017507 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045017508 homodimer interface [polypeptide binding]; other site 653045017509 catalytic residue [active] 653045017510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045017511 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045017512 classical (c) SDRs; Region: SDR_c; cd05233 653045017513 NAD(P) binding site [chemical binding]; other site 653045017514 active site 653045017515 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 653045017516 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045017517 active site 653045017518 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045017519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045017520 DNA binding residues [nucleotide binding] 653045017521 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045017522 Coenzyme A binding pocket [chemical binding]; other site 653045017523 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 653045017524 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045017525 inhibitor-cofactor binding pocket; inhibition site 653045017526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045017527 catalytic residue [active] 653045017528 Cupin domain; Region: Cupin_2; cl09118 653045017529 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 653045017530 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 653045017531 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045017532 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045017533 catalytic residue [active] 653045017534 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 653045017535 dimer interface [polypeptide binding]; other site 653045017536 NADP binding site [chemical binding]; other site 653045017537 catalytic residues [active] 653045017538 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045017539 Helix-turn-helix domains; Region: HTH; cl00088 653045017540 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045017541 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045017542 Histidine kinase; Region: HisKA_3; pfam07730 653045017543 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045017544 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045017545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045017546 active site 653045017547 phosphorylation site [posttranslational modification] 653045017548 intermolecular recognition site; other site 653045017549 dimerization interface [polypeptide binding]; other site 653045017550 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045017551 DNA binding residues [nucleotide binding] 653045017552 dimerization interface [polypeptide binding]; other site 653045017553 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045017554 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045017555 active site 653045017556 catalytic tetrad [active] 653045017557 parallel beta-helix repeat-containing protein; Region: beta_helix_1; TIGR03805 653045017558 Right handed beta helix region; Region: Beta_helix; pfam13229 653045017559 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 653045017560 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 653045017561 NodB motif; other site 653045017562 active site 653045017563 catalytic site [active] 653045017564 metal binding site [ion binding]; metal-binding site 653045017565 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045017566 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045017567 Methane oxygenase PmoA; Region: PmoA; pfam14100 653045017568 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045017569 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017570 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045017571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045017572 dimer interface [polypeptide binding]; other site 653045017573 conserved gate region; other site 653045017574 putative PBP binding loops; other site 653045017575 ABC-ATPase subunit interface; other site 653045017576 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 653045017577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045017578 dimer interface [polypeptide binding]; other site 653045017579 conserved gate region; other site 653045017580 putative PBP binding loops; other site 653045017581 ABC-ATPase subunit interface; other site 653045017582 Dehydratase family; Region: ILVD_EDD; cl00340 653045017583 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 653045017584 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 653045017585 inhibitor site; inhibition site 653045017586 active site 653045017587 dimer interface [polypeptide binding]; other site 653045017588 catalytic residue [active] 653045017589 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045017590 DNA-binding site [nucleotide binding]; DNA binding site 653045017591 FCD domain; Region: FCD; cl11656 653045017592 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 653045017593 5-dehydro-4-deoxyglucarate dehydratase, also called 5-keto-4-deoxy-glucarate dehydratase (KDGDH); Region: KDGDH; cd00951 653045017594 putative active site [active] 653045017595 catalytic residue [active] 653045017596 NADH(P)-binding; Region: NAD_binding_10; pfam13460 653045017597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017598 NAD(P) binding site [chemical binding]; other site 653045017599 active site 653045017600 Isochorismatase family; Region: Isochorismatase; pfam00857 653045017601 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 653045017602 catalytic triad [active] 653045017603 conserved cis-peptide bond; other site 653045017604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045017605 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045017606 putative substrate translocation pore; other site 653045017607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045017608 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045017609 Helix-turn-helix domains; Region: HTH; cl00088 653045017610 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 653045017611 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 653045017612 potential catalytic triad [active] 653045017613 conserved cys residue [active] 653045017614 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045017615 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045017616 substrate binding pocket [chemical binding]; other site 653045017617 membrane-bound complex binding site; other site 653045017618 hinge residues; other site 653045017619 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 653045017620 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 653045017621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045017622 Lamin Tail Domain; Region: LTD; pfam00932 653045017623 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045017624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045017625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045017626 Helix-turn-helix domains; Region: HTH; cl00088 653045017627 EamA-like transporter family; Region: EamA; cl01037 653045017628 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045017629 putative metal binding site [ion binding]; other site 653045017630 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045017631 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045017632 putative metal binding site [ion binding]; other site 653045017633 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 653045017634 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 653045017635 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045017636 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 653045017637 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 653045017638 generic binding surface I; other site 653045017639 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 653045017640 putative catalytic site [active] 653045017641 putative metal binding site [ion binding]; other site 653045017642 putative phosphate binding site [ion binding]; other site 653045017643 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 653045017644 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 653045017645 putative trimer interface [polypeptide binding]; other site 653045017646 putative CoA binding site [chemical binding]; other site 653045017647 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 653045017648 Helix-turn-helix domains; Region: HTH; cl00088 653045017649 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045017650 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 653045017651 Domain of unknown function DUF59; Region: DUF59; cl00941 653045017652 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 653045017653 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 653045017654 trimerization site [polypeptide binding]; other site 653045017655 active site 653045017656 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 653045017657 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 653045017658 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045017659 catalytic residue [active] 653045017660 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 653045017661 FeS assembly ATPase SufC; Region: sufC; TIGR01978 653045017662 Walker A/P-loop; other site 653045017663 ATP binding site [chemical binding]; other site 653045017664 Q-loop/lid; other site 653045017665 ABC transporter signature motif; other site 653045017666 Walker B; other site 653045017667 D-loop; other site 653045017668 H-loop/switch region; other site 653045017669 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 653045017670 [2Fe-2S] cluster binding site [ion binding]; other site 653045017671 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 653045017672 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 653045017673 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 653045017674 FeS assembly protein SufB; Region: sufB; TIGR01980 653045017675 Predicted transcriptional regulator [Transcription]; Region: COG2345 653045017676 Helix-turn-helix domains; Region: HTH; cl00088 653045017677 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045017678 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 653045017679 Walker A/P-loop; other site 653045017680 ATP binding site [chemical binding]; other site 653045017681 Q-loop/lid; other site 653045017682 ABC transporter signature motif; other site 653045017683 Walker B; other site 653045017684 D-loop; other site 653045017685 H-loop/switch region; other site 653045017686 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045017687 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 653045017688 UbiA prenyltransferase family; Region: UbiA; cl00337 653045017689 transketolase; Reviewed; Region: PRK05899 653045017690 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 653045017691 TPP-binding site [chemical binding]; other site 653045017692 dimer interface [polypeptide binding]; other site 653045017693 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 653045017694 PYR/PP interface [polypeptide binding]; other site 653045017695 dimer interface [polypeptide binding]; other site 653045017696 TPP binding site [chemical binding]; other site 653045017697 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 653045017698 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 653045017699 putative active site [active] 653045017700 transaldolase; Provisional; Region: PRK03903 653045017701 catalytic residue [active] 653045017702 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 653045017703 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 653045017704 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 653045017705 opcA protein; Region: OpcA; TIGR00534 653045017706 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 653045017707 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 653045017708 putative active site [active] 653045017709 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 653045017710 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 653045017711 active site 653045017712 dimer interface [polypeptide binding]; other site 653045017713 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 653045017714 dimer interface [polypeptide binding]; other site 653045017715 active site 653045017716 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045017717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045017718 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 653045017719 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 653045017720 substrate binding site [chemical binding]; other site 653045017721 dimer interface [polypeptide binding]; other site 653045017722 catalytic triad [active] 653045017723 Phosphoglycerate kinase; Region: PGK; pfam00162 653045017724 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 653045017725 substrate binding site [chemical binding]; other site 653045017726 hinge regions; other site 653045017727 ADP binding site [chemical binding]; other site 653045017728 catalytic site [active] 653045017729 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017730 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 653045017731 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 653045017732 Peptidase M14 Carboxypeptidase T subfamily; Region: M14_CPT; cd03859 653045017733 putative active site [active] 653045017734 Zn binding site [ion binding]; other site 653045017735 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 653045017736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 653045017737 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 653045017738 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 653045017739 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 653045017740 putative substrate binding pocket [chemical binding]; other site 653045017741 dimer interface [polypeptide binding]; other site 653045017742 phosphate binding site [ion binding]; other site 653045017743 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 653045017744 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 653045017745 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 653045017746 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 653045017747 GIY-YIG motif/motif A; other site 653045017748 active site 653045017749 catalytic site [active] 653045017750 putative DNA binding site [nucleotide binding]; other site 653045017751 metal binding site [ion binding]; metal-binding site 653045017752 UvrB/uvrC motif; Region: UVR; pfam02151 653045017753 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 653045017754 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 653045017755 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 653045017756 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 653045017757 iron-sulfur cluster [ion binding]; other site 653045017758 [2Fe-2S] cluster binding site [ion binding]; other site 653045017759 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045017760 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045017761 DNA binding site [nucleotide binding] 653045017762 domain linker motif; other site 653045017763 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045017764 ligand binding site [chemical binding]; other site 653045017765 dimerization interface [polypeptide binding]; other site 653045017766 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 653045017767 putative substrate binding site [chemical binding]; other site 653045017768 putative ATP binding site [chemical binding]; other site 653045017769 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 653045017770 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 653045017771 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 653045017772 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 653045017773 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045017774 TIGR03085 family protein; Region: TIGR03085 653045017775 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045017776 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045017777 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045017778 putative substrate translocation pore; other site 653045017779 Integral membrane protein TerC family; Region: TerC; cl10468 653045017780 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045017781 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045017782 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045017783 putative metal binding site [ion binding]; other site 653045017784 excinuclease ABC subunit B; Provisional; Region: PRK05298 653045017785 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017786 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045017787 nucleotide binding region [chemical binding]; other site 653045017788 ATP-binding site [chemical binding]; other site 653045017789 Ultra-violet resistance protein B; Region: UvrB; pfam12344 653045017790 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 653045017791 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 653045017792 active site 653045017793 catalytic site [active] 653045017794 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 653045017795 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 653045017796 DNA binding site [nucleotide binding] 653045017797 active site 653045017798 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 653045017799 Domain of unknown function (DUF4360); Region: DUF4360; pfam14273 653045017800 uridine kinase; Validated; Region: PRK06696 653045017801 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 653045017802 PemK-like protein; Region: PemK; cl00995 653045017803 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 653045017804 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 653045017805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 653045017806 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 653045017807 dephospho-CoA kinase; Region: TIGR00152 653045017808 CoA-binding site [chemical binding]; other site 653045017809 ATP-binding [chemical binding]; other site 653045017810 PAC2 family; Region: PAC2; cl00847 653045017811 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 653045017812 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 653045017813 RNA binding site [nucleotide binding]; other site 653045017814 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 653045017815 RNA binding site [nucleotide binding]; other site 653045017816 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 653045017817 RNA binding site [nucleotide binding]; other site 653045017818 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 653045017819 RNA binding site [nucleotide binding]; other site 653045017820 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045017821 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 653045017822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017823 ATP binding site [chemical binding]; other site 653045017824 putative Mg++ binding site [ion binding]; other site 653045017825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017826 Helicase associated domain (HA2); Region: HA2; cl04503 653045017827 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 653045017828 Protein of unknown function (DUF3068); Region: DUF3068; pfam11271 653045017829 Membrane-bound lytic murein transglycosylase B [Cell envelope biogenesis, outer membrane]; Region: MltB; COG2951 653045017830 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 653045017831 N-acetyl-D-glucosamine binding site [chemical binding]; other site 653045017832 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045017833 DNA polymerase I; Provisional; Region: PRK05755 653045017834 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 653045017835 active site 653045017836 metal binding site 1 [ion binding]; metal-binding site 653045017837 putative 5' ssDNA interaction site; other site 653045017838 metal binding site 3; metal-binding site 653045017839 metal binding site 2 [ion binding]; metal-binding site 653045017840 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 653045017841 putative DNA binding site [nucleotide binding]; other site 653045017842 putative metal binding site [ion binding]; other site 653045017843 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 653045017844 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 653045017845 active site 653045017846 DNA binding site [nucleotide binding] 653045017847 catalytic site [active] 653045017848 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 653045017849 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 653045017850 putative molybdopterin cofactor binding site [chemical binding]; other site 653045017851 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 653045017852 putative molybdopterin cofactor binding site; other site 653045017853 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 653045017854 CoenzymeA binding site [chemical binding]; other site 653045017855 subunit interaction site [polypeptide binding]; other site 653045017856 PHB binding site; other site 653045017857 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 653045017858 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 653045017859 dimerization interface [polypeptide binding]; other site 653045017860 ligand binding site [chemical binding]; other site 653045017861 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 653045017862 TM-ABC transporter signature motif; other site 653045017863 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 653045017864 TM-ABC transporter signature motif; other site 653045017865 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 653045017866 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 653045017867 Walker A/P-loop; other site 653045017868 ATP binding site [chemical binding]; other site 653045017869 Q-loop/lid; other site 653045017870 ABC transporter signature motif; other site 653045017871 Walker B; other site 653045017872 D-loop; other site 653045017873 H-loop/switch region; other site 653045017874 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 653045017875 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 653045017876 Walker A/P-loop; other site 653045017877 ATP binding site [chemical binding]; other site 653045017878 Q-loop/lid; other site 653045017879 ABC transporter signature motif; other site 653045017880 Walker B; other site 653045017881 D-loop; other site 653045017882 H-loop/switch region; other site 653045017883 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 653045017884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045017885 active site 653045017886 phosphorylation site [posttranslational modification] 653045017887 intermolecular recognition site; other site 653045017888 dimerization interface [polypeptide binding]; other site 653045017889 ANTAR domain; Region: ANTAR; cl04297 653045017890 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045017891 pyruvate kinase; Provisional; Region: PRK06247 653045017892 domain interfaces; other site 653045017893 active site 653045017894 Protein of unknown function (DUF541); Region: SIMPL; cl01077 653045017895 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 653045017896 2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390 653045017897 active site 653045017898 metal binding site [ion binding]; metal-binding site 653045017899 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 653045017900 L-lysine 6-monooxygenase (NADPH-requiring); Region: K_oxygenase; pfam13434 653045017901 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045017902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045017903 catalytic residue [active] 653045017904 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 653045017905 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 653045017906 Zn binding site [ion binding]; other site 653045017907 Chorismate mutase type II; Region: CM_2; cl00693 653045017908 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045017909 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045017910 active site 653045017911 metal binding site [ion binding]; metal-binding site 653045017912 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 653045017913 cleavage site 653045017914 active site 653045017915 substrate binding sites [chemical binding]; other site 653045017916 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045017917 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045017918 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045017919 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 653045017920 Walker A/P-loop; other site 653045017921 ATP binding site [chemical binding]; other site 653045017922 Q-loop/lid; other site 653045017923 ABC transporter signature motif; other site 653045017924 Walker B; other site 653045017925 D-loop; other site 653045017926 H-loop/switch region; other site 653045017927 Predicted transcriptional regulators [Transcription]; Region: COG1725 653045017928 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045017929 DNA-binding site [nucleotide binding]; DNA binding site 653045017930 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 653045017931 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017932 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045017933 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 653045017934 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 653045017935 active site 653045017936 dimer interface [polypeptide binding]; other site 653045017937 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 653045017938 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 653045017939 active site 653045017940 FMN binding site [chemical binding]; other site 653045017941 substrate binding site [chemical binding]; other site 653045017942 3Fe-4S cluster binding site [ion binding]; other site 653045017943 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 653045017944 domain interface; other site 653045017945 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 653045017946 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 653045017947 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045017948 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 653045017949 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 653045017950 substrate binding site [chemical binding]; other site 653045017951 active site 653045017952 catalytic residues [active] 653045017953 heterodimer interface [polypeptide binding]; other site 653045017954 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 653045017955 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 653045017956 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045017957 catalytic residue [active] 653045017958 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 653045017959 active site 653045017960 ribulose/triose binding site [chemical binding]; other site 653045017961 phosphate binding site [ion binding]; other site 653045017962 substrate (anthranilate) binding pocket [chemical binding]; other site 653045017963 product (indole) binding pocket [chemical binding]; other site 653045017964 trp region conserved hypothetical membrane protein; Region: trp_oprn_chp; TIGR02234 653045017965 anthranilate synthase component I; Provisional; Region: PRK13571 653045017966 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 653045017967 chorismate binding enzyme; Region: Chorismate_bind; cl10555 653045017968 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 653045017969 Septum formation; Region: Septum_form; pfam13845 653045017970 TIGR03085 family protein; Region: TIGR03085 653045017971 TM1410 hypothetical-related protein; Region: DUF297; cl00997 653045017972 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 653045017973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045017974 NAD(P) binding site [chemical binding]; other site 653045017975 active site 653045017976 OsmC-like protein; Region: OsmC; cl00767 653045017977 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 653045017978 FMN binding site [chemical binding]; other site 653045017979 active site 653045017980 substrate binding site [chemical binding]; other site 653045017981 catalytic residue [active] 653045017982 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 653045017983 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045017984 DNA binding residues [nucleotide binding] 653045017985 putative dimer interface [polypeptide binding]; other site 653045017986 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 653045017987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045017988 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045017989 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 653045017990 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 653045017991 substrate binding site [chemical binding]; other site 653045017992 glutamase interaction surface [polypeptide binding]; other site 653045017993 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 653045017994 homotrimer interaction site [polypeptide binding]; other site 653045017995 putative active site [active] 653045017996 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106 653045017997 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 653045017998 catalytic residues [active] 653045017999 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 653045018000 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 653045018001 putative active site [active] 653045018002 oxyanion strand; other site 653045018003 catalytic triad [active] 653045018004 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 653045018005 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 653045018006 putative active site pocket [active] 653045018007 4-fold oligomerization interface [polypeptide binding]; other site 653045018008 metal binding residues [ion binding]; metal-binding site 653045018009 3-fold/trimer interface [polypeptide binding]; other site 653045018010 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 653045018011 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045018012 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045018013 homodimer interface [polypeptide binding]; other site 653045018014 catalytic residue [active] 653045018015 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 653045018016 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 653045018017 NAD binding site [chemical binding]; other site 653045018018 dimerization interface [polypeptide binding]; other site 653045018019 product binding site; other site 653045018020 substrate binding site [chemical binding]; other site 653045018021 zinc binding site [ion binding]; other site 653045018022 catalytic residues [active] 653045018023 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 653045018024 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 653045018025 putative deacylase active site [active] 653045018026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045018027 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045018028 Walker A/P-loop; other site 653045018029 ATP binding site [chemical binding]; other site 653045018030 Q-loop/lid; other site 653045018031 ABC transporter signature motif; other site 653045018032 Walker B; other site 653045018033 D-loop; other site 653045018034 H-loop/switch region; other site 653045018035 LabA_like proteins; Region: LabA_like; cd06167 653045018036 putative metal binding site [ion binding]; other site 653045018037 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 653045018038 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 653045018039 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 653045018040 generic binding surface II; other site 653045018041 generic binding surface I; other site 653045018042 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 653045018043 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045018044 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045018045 PhoD-like phosphatase; Region: PhoD; pfam09423 653045018046 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 653045018047 putative active site [active] 653045018048 putative metal binding site [ion binding]; other site 653045018049 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 653045018050 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 653045018051 Mechanosensitive ion channel; Region: MS_channel; pfam00924 653045018052 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045018053 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 653045018054 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 653045018055 RNA binding surface [nucleotide binding]; other site 653045018056 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 653045018057 active site 653045018058 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 653045018059 lipoprotein signal peptidase; Provisional; Region: PRK14787 653045018060 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 653045018061 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 653045018062 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 653045018063 HIGH motif; other site 653045018064 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 653045018065 active site 653045018066 KMSKS motif; other site 653045018067 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 653045018068 tRNA binding surface [nucleotide binding]; other site 653045018069 anticodon binding site; other site 653045018070 DivIVA domain; Region: DivI1A_domain; TIGR03544 653045018071 Plant ATP synthase F0; Region: YMF19; cl07975 653045018072 YGGT family; Region: YGGT; cl00508 653045018073 Protein of unknown function (DUF552); Region: DUF552; cl00775 653045018074 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 653045018075 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045018076 catalytic residue [active] 653045018077 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 653045018078 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 653045018079 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 653045018080 nucleotide binding site [chemical binding]; other site 653045018081 SulA interaction site; other site 653045018082 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 653045018083 Cell division protein FtsQ; Region: FtsQ; pfam03799 653045018084 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 653045018085 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 653045018086 active site 653045018087 homodimer interface [polypeptide binding]; other site 653045018088 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 653045018089 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 653045018090 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018091 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 653045018092 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 653045018093 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 653045018094 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 653045018095 Mg++ binding site [ion binding]; other site 653045018096 putative catalytic motif [active] 653045018097 putative substrate binding site [chemical binding]; other site 653045018098 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 653045018099 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 653045018100 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 653045018101 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 653045018102 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 653045018103 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 653045018104 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 653045018105 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 653045018106 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 653045018107 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 653045018108 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045018109 Septum formation initiator; Region: DivIC; cl11433 653045018110 envelope glycoprotein C; Provisional; Region: PHA03269 653045018111 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 653045018112 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045018113 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 653045018114 active site clefts [active] 653045018115 zinc binding site [ion binding]; other site 653045018116 dimer interface [polypeptide binding]; other site 653045018117 MoxR-like ATPases [General function prediction only]; Region: COG0714 653045018118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045018119 Walker A motif; other site 653045018120 ATP binding site [chemical binding]; other site 653045018121 Walker B motif; other site 653045018122 arginine finger; other site 653045018123 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 653045018124 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 653045018125 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 653045018126 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 653045018127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045018128 S-adenosylmethionine binding site [chemical binding]; other site 653045018129 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 653045018130 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045018131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045018132 Helix-turn-helix domains; Region: HTH; cl00088 653045018133 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 653045018134 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 653045018135 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 653045018136 FAD binding site [chemical binding]; other site 653045018137 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 653045018138 thiamine phosphate binding site [chemical binding]; other site 653045018139 active site 653045018140 pyrophosphate binding site [ion binding]; other site 653045018141 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045018142 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 653045018143 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045018144 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 653045018145 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 653045018146 thiS-thiF/thiG interaction site; other site 653045018147 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 653045018148 ThiS interaction site; other site 653045018149 putative active site [active] 653045018150 tetramer interface [polypeptide binding]; other site 653045018151 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045018152 hydrophobic ligand binding site; other site 653045018153 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045018154 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045018155 active site 653045018156 ATP binding site [chemical binding]; other site 653045018157 substrate binding site [chemical binding]; other site 653045018158 activation loop (A-loop); other site 653045018159 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 653045018160 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 653045018161 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 653045018162 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 653045018163 AP endonuclease family 2; Region: AP2Ec; smart00518 653045018164 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 653045018165 AP (apurinic/apyrimidinic) site pocket; other site 653045018166 DNA interaction; other site 653045018167 Metal-binding active site; metal-binding site 653045018168 Domain of unknown function (DUF4396); Region: DUF4396; pfam14342 653045018169 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 653045018170 Moco binding site; other site 653045018171 metal coordination site [ion binding]; other site 653045018172 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 653045018173 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 653045018174 heme binding site [chemical binding]; other site 653045018175 ferroxidase pore; other site 653045018176 ferroxidase diiron center [ion binding]; other site 653045018177 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 653045018178 Class-II DAHP synthetase family; Region: DAHP_synth_2; cl03230 653045018179 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045018180 putative active site [active] 653045018181 chorismate binding enzyme; Region: Chorismate_bind; cl10555 653045018182 Glutamine amidotransferase class-I; Region: GATase; pfam00117 653045018183 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 653045018184 glutamine binding [chemical binding]; other site 653045018185 catalytic triad [active] 653045018186 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cd00363 653045018187 active site 653045018188 ADP/pyrophosphate binding site [chemical binding]; other site 653045018189 dimerization interface [polypeptide binding]; other site 653045018190 allosteric effector site; other site 653045018191 fructose-1,6-bisphosphate binding site; other site 653045018192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045018193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045018194 active site 653045018195 phosphorylation site [posttranslational modification] 653045018196 intermolecular recognition site; other site 653045018197 dimerization interface [polypeptide binding]; other site 653045018198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045018199 DNA binding residues [nucleotide binding] 653045018200 dimerization interface [polypeptide binding]; other site 653045018201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045018202 ATP binding site [chemical binding]; other site 653045018203 Mg2+ binding site [ion binding]; other site 653045018204 G-X-G motif; other site 653045018205 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 653045018206 putative acyl-acceptor binding pocket; other site 653045018207 Esterase/lipase [General function prediction only]; Region: COG1647 653045018208 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 653045018209 putative catalytic site [active] 653045018210 putative metal binding site [ion binding]; other site 653045018211 putative phosphate binding site [ion binding]; other site 653045018212 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 653045018213 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045018214 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 653045018215 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045018216 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819 653045018217 putative hydrophobic ligand binding site [chemical binding]; other site 653045018218 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 653045018219 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045018220 active site 653045018221 metal binding site [ion binding]; metal-binding site 653045018222 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 653045018223 AMP-binding enzyme; Region: AMP-binding; cl15778 653045018224 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 653045018225 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 653045018226 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 653045018227 NlpC/P60 family; Region: NLPC_P60; cl11438 653045018228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 653045018229 NlpC/P60 family; Region: NLPC_P60; cl11438 653045018230 YacP-like NYN domain; Region: NYN_YacP; cl01491 653045018231 Rhomboid family; Region: Rhomboid; cl11446 653045018232 Helix-turn-helix domains; Region: HTH; cl00088 653045018233 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045018234 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045018235 catalytic residue [active] 653045018236 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 653045018237 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 653045018238 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 653045018239 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 653045018240 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 653045018241 heme bH binding site [chemical binding]; other site 653045018242 intrachain domain interface; other site 653045018243 heme bL binding site [chemical binding]; other site 653045018244 interchain domain interface [polypeptide binding]; other site 653045018245 Qo binding site; other site 653045018246 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 653045018247 iron-sulfur cluster [ion binding]; other site 653045018248 [2Fe-2S] cluster binding site [ion binding]; other site 653045018249 Cytochrome c; Region: Cytochrom_C; cl11414 653045018250 Cytochrome c; Region: Cytochrom_C; cl11414 653045018251 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 653045018252 Subunit I/III interface [polypeptide binding]; other site 653045018253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045018254 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 653045018255 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 653045018256 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 653045018257 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 653045018258 D-pathway; other site 653045018259 Putative ubiquinol binding site [chemical binding]; other site 653045018260 Low-spin heme (heme b) binding site [chemical binding]; other site 653045018261 Putative water exit pathway; other site 653045018262 Binuclear center (heme o3/CuB) [ion binding]; other site 653045018263 K-pathway; other site 653045018264 Putative proton exit pathway; other site 653045018265 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 653045018266 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045018267 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 653045018268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045018269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045018270 catalytic residue [active] 653045018271 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 653045018272 CPxP motif; other site 653045018273 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045018274 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 653045018275 substrate binding site [chemical binding]; other site 653045018276 ATP binding site [chemical binding]; other site 653045018277 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 653045018278 Quinolinate synthetase A protein; Region: NadA; cl00420 653045018279 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045018280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045018281 active site 653045018282 phosphorylation site [posttranslational modification] 653045018283 intermolecular recognition site; other site 653045018284 dimerization interface [polypeptide binding]; other site 653045018285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045018286 DNA binding residues [nucleotide binding] 653045018287 dimerization interface [polypeptide binding]; other site 653045018288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045018289 Histidine kinase; Region: HisKA_3; pfam07730 653045018290 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045018291 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 653045018292 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 653045018293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045018294 S-adenosylmethionine binding site [chemical binding]; other site 653045018295 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 653045018296 homotrimer interface [polypeptide binding]; other site 653045018297 Walker A motif; other site 653045018298 GTP binding site [chemical binding]; other site 653045018299 Walker B motif; other site 653045018300 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 653045018301 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 653045018302 active site pocket [active] 653045018303 putative dimer interface [polypeptide binding]; other site 653045018304 putative cataytic base [active] 653045018305 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 653045018306 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 653045018307 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 653045018308 interface (dimer of trimers) [polypeptide binding]; other site 653045018309 Substrate-binding/catalytic site; other site 653045018310 Zn-binding sites [ion binding]; other site 653045018311 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 653045018312 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045018313 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 653045018314 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 653045018315 E3 interaction surface; other site 653045018316 lipoyl attachment site [posttranslational modification]; other site 653045018317 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 653045018318 E3 interaction surface; other site 653045018319 lipoyl attachment site [posttranslational modification]; other site 653045018320 e3 binding domain; Region: E3_binding; pfam02817 653045018321 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 653045018322 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 653045018323 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 653045018324 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045018325 DNA-binding site [nucleotide binding]; DNA binding site 653045018326 FCD domain; Region: FCD; cl11656 653045018327 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 653045018328 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 653045018329 dimer interface [polypeptide binding]; other site 653045018330 TPP-binding site [chemical binding]; other site 653045018331 Helix-turn-helix domains; Region: HTH; cl00088 653045018332 WYL domain; Region: WYL; cl14852 653045018333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018334 NAD(P) binding site [chemical binding]; other site 653045018335 active site 653045018336 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 653045018337 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 653045018338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045018339 Coenzyme A binding pocket [chemical binding]; other site 653045018340 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018341 TIGR01777 family protein; Region: yfcH 653045018342 NAD(P) binding site [chemical binding]; other site 653045018343 active site 653045018344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018345 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045018346 putative DNA binding site [nucleotide binding]; other site 653045018347 putative Zn2+ binding site [ion binding]; other site 653045018348 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 653045018349 lipoyl synthase; Provisional; Region: PRK05481 653045018350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045018351 FeS/SAM binding site; other site 653045018352 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 653045018353 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 653045018354 RDD family; Region: RDD; cl00746 653045018355 glutamine synthetase, type I; Region: GlnA; TIGR00653 653045018356 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 653045018357 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 653045018358 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045018359 LysE type translocator; Region: LysE; cl00565 653045018360 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045018361 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045018362 Walker A/P-loop; other site 653045018363 ATP binding site [chemical binding]; other site 653045018364 Q-loop/lid; other site 653045018365 ABC transporter signature motif; other site 653045018366 Walker B; other site 653045018367 D-loop; other site 653045018368 H-loop/switch region; other site 653045018369 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 653045018370 dimer interface [polypeptide binding]; other site 653045018371 substrate binding site [chemical binding]; other site 653045018372 metal binding sites [ion binding]; metal-binding site 653045018373 Helix-turn-helix domains; Region: HTH; cl00088 653045018374 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 653045018375 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045018376 putative NAD(P) binding site [chemical binding]; other site 653045018377 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045018378 Helix-turn-helix domains; Region: HTH; cl00088 653045018379 FCD domain; Region: FCD; cl11656 653045018380 Cupin domain; Region: Cupin_2; cl09118 653045018381 Predicted amidohydrolase [General function prediction only]; Region: COG0388 653045018382 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 653045018383 putative active site [active] 653045018384 catalytic triad [active] 653045018385 putative dimer interface [polypeptide binding]; other site 653045018386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018387 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045018388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018389 Protein of unknown function (DUF2848); Region: DUF2848; pfam11010 653045018390 SPW repeat; Region: SPW; pfam03779 653045018391 SPW repeat; Region: SPW; pfam03779 653045018392 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 653045018393 putative substrate binding pocket [chemical binding]; other site 653045018394 trimer interface [polypeptide binding]; other site 653045018395 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045018396 DNA binding site [nucleotide binding] 653045018397 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045018398 Putative sensor; Region: Sensor; pfam13796 653045018399 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045018400 Histidine kinase; Region: HisKA_3; pfam07730 653045018401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045018402 Plant protein of unknown function (DUF946); Region: DUF946; pfam06101 653045018403 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045018404 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045018405 active site 653045018406 phosphorylation site [posttranslational modification] 653045018407 intermolecular recognition site; other site 653045018408 dimerization interface [polypeptide binding]; other site 653045018409 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045018410 DNA binding residues [nucleotide binding] 653045018411 dimerization interface [polypeptide binding]; other site 653045018412 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 653045018413 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 653045018414 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 653045018415 alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103 653045018416 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 653045018417 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 653045018418 Ca binding site [ion binding]; other site 653045018419 active site 653045018420 catalytic site [active] 653045018421 Domain of unknown function (DUF3372); Region: DUF3372; pfam11852 653045018422 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 653045018423 active site 653045018424 Ca binding site [ion binding]; other site 653045018425 catalytic site [active] 653045018426 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 653045018427 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045018428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045018429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045018430 DNA binding site [nucleotide binding] 653045018431 domain linker motif; other site 653045018432 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 653045018433 putative dimerization interface [polypeptide binding]; other site 653045018434 putative ligand binding site [chemical binding]; other site 653045018435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045018436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045018437 dimer interface [polypeptide binding]; other site 653045018438 conserved gate region; other site 653045018439 putative PBP binding loops; other site 653045018440 ABC-ATPase subunit interface; other site 653045018441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045018442 dimer interface [polypeptide binding]; other site 653045018443 conserved gate region; other site 653045018444 putative PBP binding loops; other site 653045018445 ABC-ATPase subunit interface; other site 653045018446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045018447 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045018448 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 653045018449 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 653045018450 active site 653045018451 catalytic site [active] 653045018452 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 653045018453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045018454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045018455 DNA binding site [nucleotide binding] 653045018456 domain linker motif; other site 653045018457 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 653045018458 putative dimerization interface [polypeptide binding]; other site 653045018459 putative ligand binding site [chemical binding]; other site 653045018460 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 653045018461 active site 653045018462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045018463 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 653045018464 active site 653045018465 motif I; other site 653045018466 motif II; other site 653045018467 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045018468 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 653045018469 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 653045018470 homodimer interface [polypeptide binding]; other site 653045018471 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045018472 catalytic residue [active] 653045018473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 653045018474 YheO-like PAS domain; Region: PAS_6; pfam08348 653045018475 Helix-turn-helix domains; Region: HTH; cl00088 653045018476 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 653045018477 Active site serine [active] 653045018478 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045018479 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045018480 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045018481 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045018482 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 653045018483 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 653045018484 metal binding triad; other site 653045018485 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 653045018486 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 653045018487 metal binding triad; other site 653045018488 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 653045018489 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 653045018490 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045018491 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 653045018492 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 653045018493 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 653045018494 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045018495 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045018496 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045018497 NAD synthetase; Provisional; Region: PRK13981 653045018498 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 653045018499 multimer interface [polypeptide binding]; other site 653045018500 active site 653045018501 catalytic triad [active] 653045018502 protein interface 1 [polypeptide binding]; other site 653045018503 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 653045018504 homodimer interface [polypeptide binding]; other site 653045018505 NAD binding pocket [chemical binding]; other site 653045018506 ATP binding pocket [chemical binding]; other site 653045018507 Mg binding site [ion binding]; other site 653045018508 active-site loop [active] 653045018509 MFS transport protein AraJ; Provisional; Region: PRK10091 653045018510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018511 putative substrate translocation pore; other site 653045018512 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 653045018513 putative catalytic site [active] 653045018514 putative metal binding site [ion binding]; other site 653045018515 putative phosphate binding site [ion binding]; other site 653045018516 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045018517 Helix-turn-helix domains; Region: HTH; cl00088 653045018518 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 653045018519 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018520 putative substrate translocation pore; other site 653045018521 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018522 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 653045018523 oligomerization interface [polypeptide binding]; other site 653045018524 active site 653045018525 metal binding site [ion binding]; metal-binding site 653045018526 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045018527 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045018528 Walker A/P-loop; other site 653045018529 ATP binding site [chemical binding]; other site 653045018530 Q-loop/lid; other site 653045018531 ABC transporter signature motif; other site 653045018532 Walker B; other site 653045018533 D-loop; other site 653045018534 H-loop/switch region; other site 653045018535 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045018536 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045018537 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045018538 Predicted ATPase [General function prediction only]; Region: COG3903 653045018539 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 653045018540 active site 653045018541 putative substrate binding region [chemical binding]; other site 653045018542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018543 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 653045018544 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045018545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045018546 dimer interface [polypeptide binding]; other site 653045018547 conserved gate region; other site 653045018548 putative PBP binding loops; other site 653045018549 ABC-ATPase subunit interface; other site 653045018550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045018551 dimer interface [polypeptide binding]; other site 653045018552 conserved gate region; other site 653045018553 ABC-ATPase subunit interface; other site 653045018554 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045018555 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045018556 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 653045018557 catalytic site [active] 653045018558 BNR repeat-like domain; Region: BNR_2; pfam13088 653045018559 Asp-box motif; other site 653045018560 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 653045018561 active site 653045018562 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 653045018563 Predicted periplasmic lipoprotein involved in iron transport [Inorganic ion transport and metabolism]; Region: COG2822 653045018564 Imelysin; Region: Peptidase_M75; cl09159 653045018565 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 653045018566 Iron permease FTR1 family; Region: FTR1; cl00475 653045018567 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 653045018568 Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566 653045018569 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 653045018570 putative active site [active] 653045018571 catalytic site [active] 653045018572 putative metal binding site [ion binding]; other site 653045018573 oligomer interface [polypeptide binding]; other site 653045018574 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 653045018575 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045018576 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045018577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018578 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 653045018579 putative substrate translocation pore; other site 653045018580 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045018581 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018582 PhoD-like phosphatase; Region: PhoD; pfam09423 653045018583 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 653045018584 putative active site [active] 653045018585 putative metal binding site [ion binding]; other site 653045018586 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 653045018587 classical (c) SDRs; Region: SDR_c; cd05233 653045018588 NAD(P) binding site [chemical binding]; other site 653045018589 active site 653045018590 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 653045018591 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045018592 active site 653045018593 Helix-turn-helix domains; Region: HTH; cl00088 653045018594 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045018595 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045018596 PAS domain; Region: PAS_9; pfam13426 653045018597 putative active site [active] 653045018598 heme pocket [chemical binding]; other site 653045018599 PAS fold; Region: PAS_4; pfam08448 653045018600 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 653045018601 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 653045018602 dimer interface [polypeptide binding]; other site 653045018603 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 653045018604 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 653045018605 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 653045018606 HSP70 interaction site [polypeptide binding]; other site 653045018607 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 653045018608 substrate binding site [polypeptide binding]; other site 653045018609 dimer interface [polypeptide binding]; other site 653045018610 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 653045018611 Clp amino terminal domain; Region: Clp_N; pfam02861 653045018612 Clp amino terminal domain; Region: Clp_N; pfam02861 653045018613 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045018614 Walker A motif; other site 653045018615 ATP binding site [chemical binding]; other site 653045018616 Walker B motif; other site 653045018617 arginine finger; other site 653045018618 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045018619 Walker A motif; other site 653045018620 ATP binding site [chemical binding]; other site 653045018621 Walker B motif; other site 653045018622 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 653045018623 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; cl09957 653045018624 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045018625 ligand binding site [chemical binding]; other site 653045018626 flexible hinge region; other site 653045018627 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 653045018628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018630 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 653045018631 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045018632 Helix-turn-helix domains; Region: HTH; cl00088 653045018633 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045018634 Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100 653045018635 active site 653045018636 citrylCoA binding site [chemical binding]; other site 653045018637 oxalacetate binding site [chemical binding]; other site 653045018638 coenzyme A binding site [chemical binding]; other site 653045018639 catalytic triad [active] 653045018640 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 653045018641 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045018642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018643 metabolite-proton symporter; Region: 2A0106; TIGR00883 653045018644 putative substrate translocation pore; other site 653045018645 Protein of unknown function (DUF2795); Region: DUF2795; pfam11387 653045018646 Protein of unknown function (DUF328); Region: DUF328; cl01143 653045018647 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 653045018648 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 653045018649 active site 653045018650 intersubunit interface [polypeptide binding]; other site 653045018651 catalytic residue [active] 653045018652 bifunctional RNase H/acid phosphatase; Provisional; Region: PRK07238 653045018653 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 653045018654 RNA/DNA hybrid binding site [nucleotide binding]; other site 653045018655 active site 653045018656 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045018657 catalytic core [active] 653045018658 Uncharacterized conserved protein [Function unknown]; Region: COG0327 653045018659 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 653045018660 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 653045018661 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 653045018662 siderophore binding site; other site 653045018663 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07792 653045018664 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018665 NAD(P) binding site [chemical binding]; other site 653045018666 active site 653045018667 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 653045018668 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 653045018669 NAD binding site [chemical binding]; other site 653045018670 catalytic Zn binding site [ion binding]; other site 653045018671 substrate binding site [chemical binding]; other site 653045018672 structural Zn binding site [ion binding]; other site 653045018673 enoyl-CoA hydratase; Region: PLN02864 653045018674 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045018675 HDE_HSD The R-hydratase-like hot dog fold of the 17-beta-hydroxysteriod dehydrogenase (HSD), and Hydratase-Dehydrogenase-Epimerase (HDE) proteins. Other enzymes with this fold include MaoC dehydratase, and the fatty acid synthase beta subunit; Region: HDE_HSD; cd03448 653045018676 dimer interaction site [polypeptide binding]; other site 653045018677 substrate-binding tunnel; other site 653045018678 active site 653045018679 catalytic site [active] 653045018680 substrate binding site [chemical binding]; other site 653045018681 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045018682 Histidine kinase; Region: HisKA_3; pfam07730 653045018683 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045018684 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045018685 active site 653045018686 phosphorylation site [posttranslational modification] 653045018687 intermolecular recognition site; other site 653045018688 dimerization interface [polypeptide binding]; other site 653045018689 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045018690 DNA binding residues [nucleotide binding] 653045018691 dimerization interface [polypeptide binding]; other site 653045018692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045018693 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 653045018694 active site 653045018695 metal binding site [ion binding]; metal-binding site 653045018696 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 653045018697 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 653045018698 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 653045018699 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 653045018700 Methyltransferase domain; Region: Methyltransf_31; pfam13847 653045018701 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045018702 S-adenosylmethionine binding site [chemical binding]; other site 653045018703 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 653045018704 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 653045018705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045018706 Helix-turn-helix domains; Region: HTH; cl00088 653045018707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045018708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 653045018709 active site 653045018710 phosphorylation site [posttranslational modification] 653045018711 intermolecular recognition site; other site 653045018712 dimerization interface [polypeptide binding]; other site 653045018713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045018714 DNA binding residues [nucleotide binding] 653045018715 dimerization interface [polypeptide binding]; other site 653045018716 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 653045018717 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045018718 Mycobacterium tuberculosis aldehyde dehydrogenase AldA-like; Region: ALDH_AldA-Rv0768; cd07139 653045018719 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045018720 NAD binding site [chemical binding]; other site 653045018721 catalytic residues [active] 653045018722 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045018723 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045018724 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045018725 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045018726 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 653045018727 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 653045018728 Cobalt transport protein; Region: CbiQ; cl00463 653045018729 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 653045018730 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 653045018731 Walker A/P-loop; other site 653045018732 ATP binding site [chemical binding]; other site 653045018733 Q-loop/lid; other site 653045018734 ABC transporter signature motif; other site 653045018735 Walker B; other site 653045018736 D-loop; other site 653045018737 H-loop/switch region; other site 653045018738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045018739 Walker A/P-loop; other site 653045018740 ATP binding site [chemical binding]; other site 653045018741 Q-loop/lid; other site 653045018742 ABC transporter signature motif; other site 653045018743 Walker B; other site 653045018744 D-loop; other site 653045018745 H-loop/switch region; other site 653045018746 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 653045018747 acetyl-CoA acetyltransferase; Provisional; Region: PRK07850 653045018748 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045018749 dimer interface [polypeptide binding]; other site 653045018750 active site 653045018751 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045018752 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045018753 classical (c) SDRs; Region: SDR_c; cd05233 653045018754 NAD(P) binding site [chemical binding]; other site 653045018755 active site 653045018756 Helix-turn-helix domains; Region: HTH; cl00088 653045018757 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045018758 dimerization interface [polypeptide binding]; other site 653045018759 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045018760 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cl00891 653045018761 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 653045018762 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 653045018763 active site 653045018764 Cupin domain; Region: Cupin_2; cl09118 653045018765 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 653045018766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045018767 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045018768 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045018769 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045018770 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045018771 active site 653045018772 catalytic tetrad [active] 653045018773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045018774 non-specific DNA binding site [nucleotide binding]; other site 653045018775 salt bridge; other site 653045018776 sequence-specific DNA binding site [nucleotide binding]; other site 653045018777 Helix-turn-helix domains; Region: HTH; cl00088 653045018778 WHG domain; Region: WHG; pfam13305 653045018779 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 653045018780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018781 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 653045018782 NAD(P) binding site [chemical binding]; other site 653045018783 active site 653045018784 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 653045018785 active site 653045018786 Omega-hydroxypalmitate O-feruloyl transferase; Region: PLN02481; cl03601 653045018787 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045018788 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045018789 active site 653045018790 phosphorylation site [posttranslational modification] 653045018791 intermolecular recognition site; other site 653045018792 dimerization interface [polypeptide binding]; other site 653045018793 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045018794 DNA binding site [nucleotide binding] 653045018795 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045018796 phosphorylation site [posttranslational modification] 653045018797 dimer interface [polypeptide binding]; other site 653045018798 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045018799 ATP binding site [chemical binding]; other site 653045018800 Mg2+ binding site [ion binding]; other site 653045018801 G-X-G motif; other site 653045018802 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045018803 Protein of unknown function (DUF1271); Region: DUF1271; cl01443 653045018804 4Fe-4S single cluster domain; Region: Fer4_15; pfam13459 653045018805 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 653045018806 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 653045018807 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 653045018808 active site 653045018809 dimer interface [polypeptide binding]; other site 653045018810 motif 1; other site 653045018811 motif 2; other site 653045018812 motif 3; other site 653045018813 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 653045018814 anticodon binding site; other site 653045018815 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045018816 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045018817 Coenzyme A binding pocket [chemical binding]; other site 653045018818 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 653045018819 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045018820 non-specific DNA binding site [nucleotide binding]; other site 653045018821 salt bridge; other site 653045018822 sequence-specific DNA binding site [nucleotide binding]; other site 653045018823 Cupin domain; Region: Cupin_2; cl09118 653045018824 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045018825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045018826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018827 putative substrate translocation pore; other site 653045018828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018829 putative substrate translocation pore; other site 653045018830 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045018831 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 653045018832 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045018833 Predicted membrane protein [Function unknown]; Region: COG2119 653045018834 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 653045018835 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 653045018836 Protein of unknown function DUF262; Region: DUF262; cl14890 653045018837 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 653045018838 putative active site [active] 653045018839 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045018840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018841 DoxX; Region: DoxX; cl00976 653045018842 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045018843 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 653045018844 N-acetyl-D-glucosamine binding site [chemical binding]; other site 653045018845 catalytic residue [active] 653045018846 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045018847 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 653045018848 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 653045018849 putative sugar binding sites [chemical binding]; other site 653045018850 Q-X-W motif; other site 653045018851 MASE1; Region: MASE1; pfam05231 653045018852 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 653045018853 putative metal binding site [ion binding]; other site 653045018854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045018855 dimerization interface [polypeptide binding]; other site 653045018856 putative DNA binding site [nucleotide binding]; other site 653045018857 putative Zn2+ binding site [ion binding]; other site 653045018858 Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798 653045018859 Membrane transport protein; Region: Mem_trans; cl09117 653045018860 Low molecular weight phosphatase family; Region: LMWPc; cd00115 653045018861 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 653045018862 active site 653045018863 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 653045018864 FAD binding domain; Region: FAD_binding_4; pfam01565 653045018865 Berberine and berberine like; Region: BBE; pfam08031 653045018866 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 653045018867 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 653045018868 oligomer interface [polypeptide binding]; other site 653045018869 active site residues [active] 653045018870 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 653045018871 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 653045018872 oligomer interface [polypeptide binding]; other site 653045018873 active site residues [active] 653045018874 Restriction endonuclease; Region: Mrr_cat; cl00516 653045018875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045018876 Helix-turn-helix domains; Region: HTH; cl00088 653045018877 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045018878 putative dimerization interface [polypeptide binding]; other site 653045018879 short chain dehydrogenase; Provisional; Region: PRK08263 653045018880 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 653045018881 NADP binding site [chemical binding]; other site 653045018882 active site 653045018883 steroid binding site; other site 653045018884 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018885 NADH(P)-binding; Region: NAD_binding_10; pfam13460 653045018886 NAD(P) binding site [chemical binding]; other site 653045018887 active site 653045018888 Predicted transcriptional regulator [Transcription]; Region: COG1959 653045018889 Helix-turn-helix domains; Region: HTH; cl00088 653045018890 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 653045018891 putative FMN binding site [chemical binding]; other site 653045018892 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 653045018893 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045018894 Helix-turn-helix domains; Region: HTH; cl00088 653045018895 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045018896 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045018897 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045018898 non-specific DNA binding site [nucleotide binding]; other site 653045018899 salt bridge; other site 653045018900 sequence-specific DNA binding site [nucleotide binding]; other site 653045018901 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045018902 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045018903 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045018904 Helix-turn-helix domains; Region: HTH; cl00088 653045018905 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 653045018906 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045018907 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045018908 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045018909 putative NAD(P) binding site [chemical binding]; other site 653045018910 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045018911 Helix-turn-helix domains; Region: HTH; cl00088 653045018912 oxidoreductase; Provisional; Region: PRK06196 653045018913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045018914 NAD(P) binding site [chemical binding]; other site 653045018915 active site 653045018916 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045018917 DNA-binding site [nucleotide binding]; DNA binding site 653045018918 RNA-binding motif; other site 653045018919 Helix-turn-helix domains; Region: HTH; cl00088 653045018920 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045018921 classical (c) SDRs; Region: SDR_c; cd05233 653045018922 NAD(P) binding site [chemical binding]; other site 653045018923 active site 653045018924 Integrase core domain; Region: rve; cl01316 653045018925 Integrase core domain; Region: rve_3; cl15866 653045018926 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045018927 active site 653045018928 metal binding site [ion binding]; metal-binding site 653045018929 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045018930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045018931 active site 653045018932 phosphorylation site [posttranslational modification] 653045018933 intermolecular recognition site; other site 653045018934 dimerization interface [polypeptide binding]; other site 653045018935 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045018936 DNA binding residues [nucleotide binding] 653045018937 dimerization interface [polypeptide binding]; other site 653045018938 Histidine kinase; Region: HisKA_3; pfam07730 653045018939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045018940 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045018941 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045018942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045018943 non-specific DNA binding site [nucleotide binding]; other site 653045018944 salt bridge; other site 653045018945 sequence-specific DNA binding site [nucleotide binding]; other site 653045018946 hypothetical protein; Provisional; Region: PRK06849 653045018947 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045018948 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045018949 S-adenosylmethionine binding site [chemical binding]; other site 653045018950 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 653045018951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045018952 O-methyltransferase; Region: Methyltransf_3; pfam01596 653045018953 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 653045018954 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 653045018955 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 653045018956 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045018957 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045018958 putative metal binding site [ion binding]; other site 653045018959 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 653045018960 Tellurium resistance protein; Region: Tellurium_res; pfam10138 653045018961 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045018962 putative metal binding site [ion binding]; other site 653045018963 Integral membrane protein TerC family; Region: TerC; cl10468 653045018964 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045018965 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045018966 putative metal binding site [ion binding]; other site 653045018967 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045018968 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045018969 putative metal binding site [ion binding]; other site 653045018970 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 653045018971 dimer interface [polypeptide binding]; other site 653045018972 catalytic triad [active] 653045018973 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 653045018974 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 653045018975 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 653045018976 dimer interface [polypeptide binding]; other site 653045018977 TPP-binding site [chemical binding]; other site 653045018978 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 653045018979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018980 putative substrate translocation pore; other site 653045018981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045018982 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045018983 Helix-turn-helix domains; Region: HTH; cl00088 653045018984 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 653045018985 Short C-terminal domain; Region: SHOCT; cl01373 653045018986 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 653045018987 Histidine kinase; Region: HisKA_3; pfam07730 653045018988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045018989 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045018990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045018991 active site 653045018992 phosphorylation site [posttranslational modification] 653045018993 intermolecular recognition site; other site 653045018994 dimerization interface [polypeptide binding]; other site 653045018995 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045018996 DNA binding residues [nucleotide binding] 653045018997 dimerization interface [polypeptide binding]; other site 653045018998 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 653045018999 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045019000 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045019001 active site 653045019002 catalytic tetrad [active] 653045019003 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 653045019004 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 653045019005 DNA binding residues [nucleotide binding] 653045019006 putative dimer interface [polypeptide binding]; other site 653045019007 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045019008 Pirin-related protein [General function prediction only]; Region: COG1741 653045019009 Cupin domain; Region: Cupin_2; cl09118 653045019010 Helix-turn-helix domains; Region: HTH; cl00088 653045019011 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045019012 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045019013 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 653045019014 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 653045019015 dimer interface [polypeptide binding]; other site 653045019016 active site 653045019017 CoA binding pocket [chemical binding]; other site 653045019018 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045019019 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 653045019020 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 653045019021 dimer interface [polypeptide binding]; other site 653045019022 active site 653045019023 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 653045019024 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045019025 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 653045019026 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 653045019027 active site 653045019028 catalytic triad [active] 653045019029 oxyanion hole [active] 653045019030 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045019031 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 653045019032 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 653045019033 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045019034 Helix-turn-helix domains; Region: HTH; cl00088 653045019035 Bacterial transcriptional repressor; Region: TetR_C_6; cl07106 653045019036 galactonate dehydratase; Provisional; Region: PRK14017 653045019037 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 653045019038 active site pocket [active] 653045019039 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045019040 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045019041 NAD(P) binding site [chemical binding]; other site 653045019042 Peptidase family U32; Region: Peptidase_U32; cl03113 653045019043 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 653045019044 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 653045019045 putative ligand binding site [chemical binding]; other site 653045019046 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 653045019047 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045019048 Walker A/P-loop; other site 653045019049 ATP binding site [chemical binding]; other site 653045019050 Q-loop/lid; other site 653045019051 ABC transporter signature motif; other site 653045019052 Walker B; other site 653045019053 D-loop; other site 653045019054 H-loop/switch region; other site 653045019055 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 653045019056 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045019057 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045019058 TM-ABC transporter signature motif; other site 653045019059 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 653045019060 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 653045019061 active site 653045019062 catalytic residues [active] 653045019063 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cl00237 653045019064 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 653045019065 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 653045019066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019067 Walker A/P-loop; other site 653045019068 ATP binding site [chemical binding]; other site 653045019069 Q-loop/lid; other site 653045019070 ABC transporter signature motif; other site 653045019071 Walker B; other site 653045019072 D-loop; other site 653045019073 H-loop/switch region; other site 653045019074 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045019075 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 653045019076 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045019077 DNA binding residues [nucleotide binding] 653045019078 dimer interface [polypeptide binding]; other site 653045019079 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045019080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045019081 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045019082 dimerization interface [polypeptide binding]; other site 653045019083 putative DNA binding site [nucleotide binding]; other site 653045019084 putative Zn2+ binding site [ion binding]; other site 653045019085 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045019086 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045019087 NAD(P) binding site [chemical binding]; other site 653045019088 active site 653045019089 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 653045019090 PHP domain; Region: PHP; pfam02811 653045019091 Pectate lyase; Region: Pec_lyase_C; cl01593 653045019092 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 653045019093 putative active site [active] 653045019094 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 653045019095 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 653045019096 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 653045019097 Prostaglandin dehydrogenases; Region: PGDH; cd05288 653045019098 NAD(P) binding site [chemical binding]; other site 653045019099 substrate binding site [chemical binding]; other site 653045019100 dimer interface [polypeptide binding]; other site 653045019101 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045019102 Helix-turn-helix domains; Region: HTH; cl00088 653045019103 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 653045019104 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 653045019105 Helix-turn-helix domains; Region: HTH; cl00088 653045019106 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045019107 OsmC-like protein; Region: OsmC; cl00767 653045019108 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045019109 catalytic core [active] 653045019110 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 653045019111 catalytic residues [active] 653045019112 FG-GAP repeat; Region: FG-GAP; cl15299 653045019113 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 653045019114 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 653045019115 trimer interface [polypeptide binding]; other site 653045019116 active site 653045019117 substrate binding site [chemical binding]; other site 653045019118 CoA binding site [chemical binding]; other site 653045019119 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045019120 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045019121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045019122 Alginate lyase; Region: Alginate_lyase2; pfam08787 653045019123 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 653045019124 active site 653045019125 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045019126 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045019127 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019128 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045019129 structural tetrad; other site 653045019130 PQQ-like domain; Region: PQQ_2; pfam13360 653045019131 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045019132 structural tetrad; other site 653045019133 Peptidase family M48; Region: Peptidase_M48; cl12018 653045019134 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045019135 non-specific DNA binding site [nucleotide binding]; other site 653045019136 salt bridge; other site 653045019137 sequence-specific DNA binding site [nucleotide binding]; other site 653045019138 Cupin domain; Region: Cupin_2; cl09118 653045019139 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 653045019140 aspartate racemase; Region: asp_race; TIGR00035 653045019141 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045019142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045019143 active site 653045019144 catalytic tetrad [active] 653045019145 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 653045019146 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 653045019147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045019148 Helix-turn-helix domains; Region: HTH; cl00088 653045019149 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 653045019150 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 653045019151 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045019152 NAD(P) binding site [chemical binding]; other site 653045019153 active site 653045019154 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045019155 Transposase, Mutator family; Region: Transposase_mut; pfam00872 653045019156 MULE transposase domain; Region: MULE; pfam10551 653045019157 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045019158 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 653045019159 N- and C-terminal domain interface [polypeptide binding]; other site 653045019160 active site 653045019161 MgATP binding site [chemical binding]; other site 653045019162 catalytic site [active] 653045019163 metal binding site [ion binding]; metal-binding site 653045019164 carbohydrate binding site [chemical binding]; other site 653045019165 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 653045019166 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 653045019167 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045019168 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045019169 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045019170 DNA binding residues [nucleotide binding] 653045019171 DNA primase; Validated; Region: dnaG; PRK05667 653045019172 CHC2 zinc finger; Region: zf-CHC2; cl15369 653045019173 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 653045019174 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 653045019175 active site 653045019176 metal binding site [ion binding]; metal-binding site 653045019177 interdomain interaction site; other site 653045019178 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; cl07879 653045019179 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 653045019180 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045019181 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 653045019182 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045019183 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 653045019184 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 653045019185 putative active site [active] 653045019186 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 653045019187 putative active site [active] 653045019188 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 653045019189 [4Fe-4S] binding site [ion binding]; other site 653045019190 molybdopterin cofactor binding site; other site 653045019191 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 653045019192 molybdopterin cofactor binding site; other site 653045019193 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 653045019194 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 653045019195 active site 653045019196 purine riboside binding site [chemical binding]; other site 653045019197 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 653045019198 putative active site [active] 653045019199 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 653045019200 Right handed beta helix region; Region: Beta_helix; pfam13229 653045019201 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 653045019202 Interdomain contacts; other site 653045019203 Cytokine receptor motif; other site 653045019204 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 653045019205 Interdomain contacts; other site 653045019206 Cytokine receptor motif; other site 653045019207 glycogen branching enzyme; Provisional; Region: PRK14705 653045019208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045019209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045019210 active site 653045019211 phosphorylation site [posttranslational modification] 653045019212 intermolecular recognition site; other site 653045019213 dimerization interface [polypeptide binding]; other site 653045019214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045019215 DNA binding site [nucleotide binding] 653045019216 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045019217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045019218 dimer interface [polypeptide binding]; other site 653045019219 phosphorylation site [posttranslational modification] 653045019220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045019221 ATP binding site [chemical binding]; other site 653045019222 Mg2+ binding site [ion binding]; other site 653045019223 G-X-G motif; other site 653045019224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045019225 ATP binding site [chemical binding]; other site 653045019226 Mg2+ binding site [ion binding]; other site 653045019227 G-X-G motif; other site 653045019228 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045019229 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045019230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019231 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045019232 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 653045019233 G1 box; other site 653045019234 G1 box; other site 653045019235 GTP/Mg2+ binding site [chemical binding]; other site 653045019236 GTP/Mg2+ binding site [chemical binding]; other site 653045019237 G2 box; other site 653045019238 Switch I region; other site 653045019239 G3 box; other site 653045019240 Switch II region; other site 653045019241 G4 box; other site 653045019242 G5 box; other site 653045019243 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045019244 Cytochrome P450; Region: p450; pfam00067 653045019245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045019246 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045019247 Probable transposase; Region: OrfB_IS605; pfam01385 653045019248 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045019249 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045019250 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 653045019251 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045019252 Cornifin (SPRR) family; Region: Cornifin; pfam02389 653045019253 nitrite reductase subunit NirD; Provisional; Region: PRK14989 653045019254 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 653045019255 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 653045019256 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 653045019257 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 653045019258 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045019259 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045019260 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045019261 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045019262 DNA binding site [nucleotide binding] 653045019263 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 653045019264 putative dimerization interface [polypeptide binding]; other site 653045019265 putative ligand binding site [chemical binding]; other site 653045019266 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045019267 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 653045019268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045019269 dimer interface [polypeptide binding]; other site 653045019270 conserved gate region; other site 653045019271 putative PBP binding loops; other site 653045019272 ABC-ATPase subunit interface; other site 653045019273 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045019274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045019275 dimer interface [polypeptide binding]; other site 653045019276 conserved gate region; other site 653045019277 putative PBP binding loops; other site 653045019278 ABC-ATPase subunit interface; other site 653045019279 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 653045019280 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045019281 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 653045019282 Fibronectin type III-like domain; Region: Fn3-like; cl15273 653045019283 Transcriptional regulators [Transcription]; Region: GntR; COG1802 653045019284 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045019285 DNA-binding site [nucleotide binding]; DNA binding site 653045019286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045019287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045019288 putative substrate translocation pore; other site 653045019289 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 653045019290 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 653045019291 short chain dehydrogenase; Provisional; Region: PRK06197 653045019292 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 653045019293 putative NAD(P) binding site [chemical binding]; other site 653045019294 active site 653045019295 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045019296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045019297 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045019298 Helix-turn-helix domains; Region: HTH; cl00088 653045019299 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045019300 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045019301 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 653045019302 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045019303 dimer interface [polypeptide binding]; other site 653045019304 active site 653045019305 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045019306 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 653045019307 active site 653045019308 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045019309 active site 653045019310 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 653045019311 3-carboxy-cis,cis-muconate cycloisomerase; Provisional; Region: PRK09053 653045019312 tetramer interface [polypeptide binding]; other site 653045019313 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 653045019314 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045019315 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045019316 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045019317 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045019318 Helix-turn-helix domains; Region: HTH; cl00088 653045019319 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045019320 classical (c) SDRs; Region: SDR_c; cd05233 653045019321 NAD(P) binding site [chemical binding]; other site 653045019322 active site 653045019323 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045019324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045019325 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045019326 dimer interface [polypeptide binding]; other site 653045019327 conserved gate region; other site 653045019328 putative PBP binding loops; other site 653045019329 ABC-ATPase subunit interface; other site 653045019330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045019331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045019332 dimer interface [polypeptide binding]; other site 653045019333 conserved gate region; other site 653045019334 putative PBP binding loops; other site 653045019335 ABC-ATPase subunit interface; other site 653045019336 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045019337 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045019338 DNA-binding site [nucleotide binding]; DNA binding site 653045019339 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045019340 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045019341 catalytic residue [active] 653045019342 amino acid transporter; Region: 2A0306; TIGR00909 653045019343 Spore germination protein; Region: Spore_permease; cl15802 653045019344 Spore germination protein; Region: Spore_permease; cl15802 653045019345 Histidine kinase; Region: HisKA_3; pfam07730 653045019346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045019347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045019348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045019349 active site 653045019350 phosphorylation site [posttranslational modification] 653045019351 intermolecular recognition site; other site 653045019352 dimerization interface [polypeptide binding]; other site 653045019353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045019354 DNA binding residues [nucleotide binding] 653045019355 dimerization interface [polypeptide binding]; other site 653045019356 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045019357 putative DNA binding site [nucleotide binding]; other site 653045019358 putative Zn2+ binding site [ion binding]; other site 653045019359 Helix-turn-helix domains; Region: HTH; cl00088 653045019360 putative transposase OrfB; Reviewed; Region: PHA02517 653045019361 HTH-like domain; Region: HTH_21; pfam13276 653045019362 Integrase core domain; Region: rve; cl01316 653045019363 Integrase core domain; Region: rve_3; cl15866 653045019364 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045019365 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 653045019366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045019367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045019368 non-specific DNA binding site [nucleotide binding]; other site 653045019369 salt bridge; other site 653045019370 sequence-specific DNA binding site [nucleotide binding]; other site 653045019371 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045019372 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045019373 active site 653045019374 DNA binding site [nucleotide binding] 653045019375 Int/Topo IB signature motif; other site 653045019376 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045019377 hypothetical protein; Validated; Region: PRK07078 653045019378 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 653045019379 active site 653045019380 metal binding site [ion binding]; metal-binding site 653045019381 interdomain interaction site; other site 653045019382 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 653045019383 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 653045019384 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 653045019385 dimer interface [polypeptide binding]; other site 653045019386 ssDNA binding site [nucleotide binding]; other site 653045019387 tetramer (dimer of dimers) interface [polypeptide binding]; other site 653045019388 Phosphotransferase enzyme family; Region: APH; pfam01636 653045019389 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045019390 substrate binding site [chemical binding]; other site 653045019391 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045019392 non-specific DNA binding site [nucleotide binding]; other site 653045019393 salt bridge; other site 653045019394 sequence-specific DNA binding site [nucleotide binding]; other site 653045019395 Domain of Unknown Function with PDB structure (DUF3857); Region: DUF3857; pfam12969 653045019396 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 653045019397 active site 653045019398 catalytic residues [active] 653045019399 metal binding site [ion binding]; metal-binding site 653045019400 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 653045019401 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 653045019402 Viral (Superfamily 1) RNA helicase; Region: Viral_helicase1; pfam01443 653045019403 Phage Terminase; Region: Terminase_1; pfam03354 653045019404 Phage-related protein [Function unknown]; Region: COG4695; cl01923 653045019405 Phage portal protein; Region: Phage_portal; pfam04860 653045019406 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 653045019407 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 653045019408 Phage capsid family; Region: Phage_capsid; pfam05065 653045019409 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 653045019410 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 653045019411 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 653045019412 amidase catalytic site [active] 653045019413 Zn binding residues [ion binding]; other site 653045019414 substrate binding site [chemical binding]; other site 653045019415 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 653045019416 putative peptidoglycan binding site; other site 653045019417 Protein of unknown function (DUF1218); Region: DUF1218; pfam06749 653045019418 pyruvate phosphate dikinase; Provisional; Region: PRK09279 653045019419 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 653045019420 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 653045019421 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 653045019422 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 653045019423 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 653045019424 active site 653045019425 zinc binding site [ion binding]; other site 653045019426 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 653045019427 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045019428 FtsX-like permease family; Region: FtsX; cl15850 653045019429 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 653045019430 FtsX-like permease family; Region: FtsX; cl15850 653045019431 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045019432 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045019433 Walker A/P-loop; other site 653045019434 ATP binding site [chemical binding]; other site 653045019435 Q-loop/lid; other site 653045019436 ABC transporter signature motif; other site 653045019437 Walker B; other site 653045019438 D-loop; other site 653045019439 H-loop/switch region; other site 653045019440 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045019441 active site 653045019442 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 653045019443 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 653045019444 FMN binding site [chemical binding]; other site 653045019445 active site 653045019446 catalytic residues [active] 653045019447 substrate binding site [chemical binding]; other site 653045019448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045019449 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045019450 putative substrate translocation pore; other site 653045019451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045019452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045019453 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045019454 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045019455 putative substrate translocation pore; other site 653045019456 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045019457 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045019458 active site 653045019459 catalytic tetrad [active] 653045019460 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045019461 Helix-turn-helix domains; Region: HTH; cl00088 653045019462 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045019463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045019464 active site 653045019465 phosphorylation site [posttranslational modification] 653045019466 intermolecular recognition site; other site 653045019467 dimerization interface [polypeptide binding]; other site 653045019468 Helix-turn-helix domains; Region: HTH; cl00088 653045019469 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045019470 Histidine kinase; Region: HisKA_3; pfam07730 653045019471 glycyl-tRNA synthetase; Provisional; Region: PRK04173 653045019472 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 653045019473 motif 1; other site 653045019474 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 653045019475 active site 653045019476 motif 2; other site 653045019477 motif 3; other site 653045019478 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 653045019479 anticodon binding site; other site 653045019480 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 653045019481 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 653045019482 intersubunit interface [polypeptide binding]; other site 653045019483 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 653045019484 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 653045019485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 653045019486 ABC-ATPase subunit interface; other site 653045019487 dimer interface [polypeptide binding]; other site 653045019488 putative PBP binding regions; other site 653045019489 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 653045019490 metal binding site 2 [ion binding]; metal-binding site 653045019491 putative DNA binding helix; other site 653045019492 metal binding site 1 [ion binding]; metal-binding site 653045019493 dimer interface [polypeptide binding]; other site 653045019494 structural Zn2+ binding site [ion binding]; other site 653045019495 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 653045019496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045019497 putative substrate translocation pore; other site 653045019498 RHS Repeat; Region: RHS_repeat; cl11982 653045019499 RHS Repeat; Region: RHS_repeat; cl11982 653045019500 RHS Repeat; Region: RHS_repeat; cl11982 653045019501 RHS Repeat; Region: RHS_repeat; cl11982 653045019502 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 653045019503 RHS Repeat; Region: RHS_repeat; cl11982 653045019504 RHS Repeat; Region: RHS_repeat; cl11982 653045019505 RHS Repeat; Region: RHS_repeat; cl11982 653045019506 RHS Repeat; Region: RHS_repeat; cl11982 653045019507 RHS Repeat; Region: RHS_repeat; cl11982 653045019508 RHS Repeat; Region: RHS_repeat; cl11982 653045019509 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 653045019510 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 653045019511 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045019512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 653045019513 Helix-turn-helix domains; Region: HTH; cl00088 653045019514 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 653045019515 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 653045019516 catalytic residue [active] 653045019517 putative FPP diphosphate binding site; other site 653045019518 putative FPP binding hydrophobic cleft; other site 653045019519 dimer interface [polypeptide binding]; other site 653045019520 putative IPP diphosphate binding site; other site 653045019521 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 653045019522 Recombination protein O N terminal; Region: RecO_N; cl15812 653045019523 Recombination protein O C terminal; Region: RecO_C; pfam02565 653045019524 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045019525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045019526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045019527 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045019528 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045019529 Helix-turn-helix domains; Region: HTH; cl00088 653045019530 putative transposase OrfB; Reviewed; Region: PHA02517 653045019531 HTH-like domain; Region: HTH_21; pfam13276 653045019532 Integrase core domain; Region: rve; cl01316 653045019533 Integrase core domain; Region: rve_3; cl15866 653045019534 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019535 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 653045019536 Ca binding site [ion binding]; other site 653045019537 Ca binding site (active) [ion binding]; other site 653045019538 ligand binding site [chemical binding]; other site 653045019539 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 653045019540 Ca binding site [ion binding]; other site 653045019541 Ca binding site (active) [ion binding]; other site 653045019542 ligand binding site [chemical binding]; other site 653045019543 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 653045019544 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 653045019545 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 653045019546 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 653045019547 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 653045019548 substrate binding site [chemical binding]; other site 653045019549 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045019550 Helix-turn-helix domains; Region: HTH; cl00088 653045019551 Helix-turn-helix domains; Region: HTH; cl00088 653045019552 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045019553 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045019554 Protein of unknown function (DUF419); Region: DUF419; cl15265 653045019555 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 653045019556 active site 653045019557 catalytic residues [active] 653045019558 Predicted acetyltransferase [General function prediction only]; Region: COG3153 653045019559 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045019560 Coenzyme A binding pocket [chemical binding]; other site 653045019561 Clp amino terminal domain; Region: Clp_N; pfam02861 653045019562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045019563 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045019564 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045019565 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 653045019566 active site 653045019567 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045019568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045019569 active site 653045019570 phosphorylation site [posttranslational modification] 653045019571 intermolecular recognition site; other site 653045019572 dimerization interface [polypeptide binding]; other site 653045019573 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045019574 DNA binding residues [nucleotide binding] 653045019575 dimerization interface [polypeptide binding]; other site 653045019576 Histidine kinase; Region: HisKA_3; pfam07730 653045019577 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045019578 Transport protein; Region: actII; TIGR00833 653045019579 Transport protein; Region: actII; TIGR00833 653045019580 2-isopropylmalate synthase; Validated; Region: PRK03739 653045019581 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 653045019582 active site 653045019583 catalytic residues [active] 653045019584 metal binding site [ion binding]; metal-binding site 653045019585 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 653045019586 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 653045019587 active site 653045019588 Zn binding site [ion binding]; other site 653045019589 GTPase Era; Reviewed; Region: era; PRK00089 653045019590 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 653045019591 G1 box; other site 653045019592 GTP/Mg2+ binding site [chemical binding]; other site 653045019593 Switch I region; other site 653045019594 G2 box; other site 653045019595 Switch II region; other site 653045019596 G3 box; other site 653045019597 G4 box; other site 653045019598 G5 box; other site 653045019599 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 653045019600 Domain of unknown function DUF21; Region: DUF21; pfam01595 653045019601 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 653045019602 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 653045019603 Transporter associated domain; Region: CorC_HlyC; cl08393 653045019604 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 653045019605 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 653045019606 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019607 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045019608 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 653045019609 substrate binding site [chemical binding]; other site 653045019610 ATP binding site [chemical binding]; other site 653045019611 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045019612 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 653045019613 nucleotide binding site/active site [active] 653045019614 HIT family signature motif; other site 653045019615 catalytic residue [active] 653045019616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 653045019617 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 653045019618 Nitronate monooxygenase; Region: NMO; pfam03060 653045019619 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 653045019620 FMN binding site [chemical binding]; other site 653045019621 substrate binding site [chemical binding]; other site 653045019622 putative catalytic residue [active] 653045019623 chaperone protein DnaJ; Provisional; Region: PRK14278 653045019624 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 653045019625 HSP70 interaction site [polypeptide binding]; other site 653045019626 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 653045019627 Zn binding sites [ion binding]; other site 653045019628 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 653045019629 dimer interface [polypeptide binding]; other site 653045019630 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 653045019631 Helix-turn-helix domains; Region: HTH; cl00088 653045019632 HrcA protein C terminal domain; Region: HrcA; pfam01628 653045019633 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045019634 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045019635 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045019636 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 653045019637 coproporphyrinogen III oxidase; Validated; Region: PRK05628 653045019638 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045019639 FeS/SAM binding site; other site 653045019640 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045019641 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045019642 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045019643 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 653045019644 AMP-binding enzyme; Region: AMP-binding; cl15778 653045019645 GTP-binding protein LepA; Provisional; Region: PRK05433 653045019646 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 653045019647 G1 box; other site 653045019648 putative GEF interaction site [polypeptide binding]; other site 653045019649 GTP/Mg2+ binding site [chemical binding]; other site 653045019650 Switch I region; other site 653045019651 G2 box; other site 653045019652 G3 box; other site 653045019653 Switch II region; other site 653045019654 G4 box; other site 653045019655 G5 box; other site 653045019656 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 653045019657 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 653045019658 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 653045019659 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 653045019660 hypothetical protein; Reviewed; Region: PRK07914 653045019661 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 653045019662 MOSC domain; Region: MOSC; pfam03473 653045019663 YdjC-like protein; Region: YdjC; cl01344 653045019664 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 653045019665 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045019666 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 653045019667 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 653045019668 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 653045019669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019670 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045019671 Walker A/P-loop; other site 653045019672 ATP binding site [chemical binding]; other site 653045019673 Q-loop/lid; other site 653045019674 ABC transporter signature motif; other site 653045019675 Walker B; other site 653045019676 D-loop; other site 653045019677 H-loop/switch region; other site 653045019678 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045019679 Competence protein; Region: Competence; cl00471 653045019680 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045019681 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 653045019682 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 653045019683 Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577 653045019684 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 653045019685 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045019686 active site 653045019687 HIGH motif; other site 653045019688 nucleotide binding site [chemical binding]; other site 653045019689 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 653045019690 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045019691 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045019692 active site 653045019693 KMSKS motif; other site 653045019694 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 653045019695 tRNA binding surface [nucleotide binding]; other site 653045019696 Probable metal-binding protein (DUF2387); Region: DUF2387; cl01410 653045019697 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045019698 catalytic core [active] 653045019699 Oligomerisation domain; Region: Oligomerisation; cl00519 653045019700 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045019701 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 653045019702 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 653045019703 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 653045019704 active site 653045019705 (T/H)XGH motif; other site 653045019706 Peptidase family M48; Region: Peptidase_M48; cl12018 653045019707 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 653045019708 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 653045019709 putative catalytic cysteine [active] 653045019710 gamma-glutamyl kinase; Provisional; Region: PRK05429 653045019711 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 653045019712 nucleotide binding site [chemical binding]; other site 653045019713 substrate binding site [chemical binding]; other site 653045019714 PUA domain; Region: PUA; cl00607 653045019715 GTPase CgtA; Reviewed; Region: obgE; PRK12296 653045019716 GTP1/OBG; Region: GTP1_OBG; pfam01018 653045019717 Obg GTPase; Region: Obg; cd01898 653045019718 G1 box; other site 653045019719 GTP/Mg2+ binding site [chemical binding]; other site 653045019720 Switch I region; other site 653045019721 G2 box; other site 653045019722 G3 box; other site 653045019723 Switch II region; other site 653045019724 G4 box; other site 653045019725 G5 box; other site 653045019726 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 653045019727 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 653045019728 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 653045019729 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 653045019730 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 653045019731 homodimer interface [polypeptide binding]; other site 653045019732 oligonucleotide binding site [chemical binding]; other site 653045019733 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 653045019734 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 653045019735 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 653045019736 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 653045019737 B12 binding site [chemical binding]; other site 653045019738 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045019739 FeS/SAM binding site; other site 653045019740 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cd07374 653045019741 putative active site; other site 653045019742 putative metal binding residues [ion binding]; other site 653045019743 signature motif; other site 653045019744 putative triphosphate binding site [ion binding]; other site 653045019745 CHAD domain; Region: CHAD; cl10506 653045019746 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 653045019747 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 653045019748 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 653045019749 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045019750 rod shape-determining protein MreC; Region: MreC; pfam04085 653045019751 rod shape-determining protein MreB; Provisional; Region: PRK13927 653045019752 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 653045019753 ATP binding site [chemical binding]; other site 653045019754 profilin binding site; other site 653045019755 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 653045019756 active site 653045019757 multimer interface [polypeptide binding]; other site 653045019758 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 653045019759 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 653045019760 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 653045019761 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 653045019762 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045019763 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 653045019764 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 653045019765 HIGH motif; other site 653045019766 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 653045019767 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 653045019768 active site 653045019769 KMSKS motif; other site 653045019770 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 653045019771 tRNA binding surface [nucleotide binding]; other site 653045019772 anticodon binding site; other site 653045019773 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 653045019774 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 653045019775 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 653045019776 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045019777 Walker A motif; other site 653045019778 ATP binding site [chemical binding]; other site 653045019779 Walker B motif; other site 653045019780 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 653045019781 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 653045019782 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 653045019783 oligomer interface [polypeptide binding]; other site 653045019784 active site residues [active] 653045019785 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 653045019786 Clp protease; Region: CLP_protease; pfam00574 653045019787 oligomer interface [polypeptide binding]; other site 653045019788 active site residues [active] 653045019789 trigger factor; Provisional; Region: tig; PRK01490 653045019790 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 653045019791 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 653045019792 OpgC protein; Region: OpgC_C; cl00792 653045019793 Acyltransferase family; Region: Acyl_transf_3; pfam01757 653045019794 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045019795 hypothetical protein; Provisional; Region: PRK01346 653045019796 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045019797 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 653045019798 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 653045019799 putative DNA binding site [nucleotide binding]; other site 653045019800 catalytic residue [active] 653045019801 putative H2TH interface [polypeptide binding]; other site 653045019802 putative catalytic residues [active] 653045019803 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 653045019804 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 653045019805 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 653045019806 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 653045019807 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 653045019808 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 653045019809 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 653045019810 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 653045019811 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 653045019812 gamma-aminobutyrate permease; Region: GABAperm; TIGR01773 653045019813 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 653045019814 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 653045019815 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 653045019816 catalytic residues [active] 653045019817 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 653045019818 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 653045019819 Zn binding site [ion binding]; other site 653045019820 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 653045019821 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 653045019822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045019823 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 653045019824 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 653045019825 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 653045019826 Zn binding site [ion binding]; other site 653045019827 Fatty acid desaturase; Region: FA_desaturase_2; pfam03405 653045019828 Acyl ACP desaturase, ferritin-like diiron-binding domain; Region: Acyl_ACP_Desat; cd01050 653045019829 homodimer interface [polypeptide binding]; other site 653045019830 putative substrate binding pocket [chemical binding]; other site 653045019831 diiron center [ion binding]; other site 653045019832 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 653045019833 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 653045019834 putative bifunctional 4-alpha-glucanotransferase/malto-oligosyltrehalose synthase; Provisional; Region: PRK14507 653045019835 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 653045019836 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 653045019837 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045019838 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 653045019839 active site 653045019840 Mechanosensitive ion channel; Region: MS_channel; pfam00924 653045019841 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cd11377 653045019842 peptidase domain interface [polypeptide binding]; other site 653045019843 Peptidase domain in the S53 family; Region: Peptidases_S53; cd04056 653045019844 active site 653045019845 catalytic triad [active] 653045019846 calcium binding site [ion binding]; other site 653045019847 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045019848 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045019849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045019850 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 653045019851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045019852 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 653045019853 ABC-ATPase subunit interface; other site 653045019854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045019855 dimer interface [polypeptide binding]; other site 653045019856 conserved gate region; other site 653045019857 putative PBP binding loops; other site 653045019858 ABC-ATPase subunit interface; other site 653045019859 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 653045019860 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 653045019861 NAD binding site [chemical binding]; other site 653045019862 sugar binding site [chemical binding]; other site 653045019863 divalent metal binding site [ion binding]; other site 653045019864 tetramer (dimer of dimers) interface [polypeptide binding]; other site 653045019865 dimer interface [polypeptide binding]; other site 653045019866 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045019867 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045019868 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 653045019869 substrate binding pocket [chemical binding]; other site 653045019870 membrane-bound complex binding site; other site 653045019871 hinge residues; other site 653045019872 chromosome segregation protein; Provisional; Region: PRK03918 653045019873 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045019874 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045019875 active site 653045019876 ATP binding site [chemical binding]; other site 653045019877 substrate binding site [chemical binding]; other site 653045019878 activation loop (A-loop); other site 653045019879 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045019880 binding surface 653045019881 Tetratricopeptide repeat; Region: TPR_16; pfam13432 653045019882 TPR motif; other site 653045019883 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 653045019884 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 653045019885 metal ion-dependent adhesion site (MIDAS); other site 653045019886 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 653045019887 phosphopeptide binding site; other site 653045019888 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045019889 S-adenosylmethionine binding site [chemical binding]; other site 653045019890 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 653045019891 apolar tunnel; other site 653045019892 heme binding site [chemical binding]; other site 653045019893 dimerization interface [polypeptide binding]; other site 653045019894 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 653045019895 active site 653045019896 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 653045019897 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019898 Walker A/P-loop; other site 653045019899 ATP binding site [chemical binding]; other site 653045019900 Q-loop/lid; other site 653045019901 ABC transporter signature motif; other site 653045019902 Walker B; other site 653045019903 D-loop; other site 653045019904 H-loop/switch region; other site 653045019905 ABC transporter; Region: ABC_tran_2; pfam12848 653045019906 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 653045019907 TQXA domain; Region: TQXA_dom; TIGR03934 653045019908 Domain of unknown function (DUF756); Region: DUF756; pfam05506 653045019909 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 653045019910 dimer interface [polypeptide binding]; other site 653045019911 ssDNA binding site [nucleotide binding]; other site 653045019912 tetramer (dimer of dimers) interface [polypeptide binding]; other site 653045019913 Dynamin family; Region: Dynamin_N; pfam00350 653045019914 YfjP GTPase; Region: YfjP; cd11383 653045019915 G1 box; other site 653045019916 GTP/Mg2+ binding site [chemical binding]; other site 653045019917 Switch I region; other site 653045019918 G2 box; other site 653045019919 Switch II region; other site 653045019920 G3 box; other site 653045019921 G4 box; other site 653045019922 G5 box; other site 653045019923 Predicted GTPase [General function prediction only]; Region: ThdF; COG0486 653045019924 Dynamin family; Region: Dynamin_N; pfam00350 653045019925 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045019926 G1 box; other site 653045019927 GTP/Mg2+ binding site [chemical binding]; other site 653045019928 G2 box; other site 653045019929 Switch I region; other site 653045019930 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 653045019931 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 653045019932 FAD binding pocket [chemical binding]; other site 653045019933 FAD binding motif [chemical binding]; other site 653045019934 phosphate binding motif [ion binding]; other site 653045019935 NAD binding pocket [chemical binding]; other site 653045019936 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 653045019937 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 653045019938 D-pathway; other site 653045019939 Putative ubiquinol binding site [chemical binding]; other site 653045019940 Low-spin heme (heme b) binding site [chemical binding]; other site 653045019941 Putative water exit pathway; other site 653045019942 Binuclear center (heme o3/CuB) [ion binding]; other site 653045019943 K-pathway; other site 653045019944 Putative proton exit pathway; other site 653045019945 SpoOM protein; Region: Spo0M; pfam07070 653045019946 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 653045019947 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 653045019948 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 653045019949 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 653045019950 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD2; cd08298 653045019951 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_2; TIGR02822 653045019952 putative NAD(P) binding site [chemical binding]; other site 653045019953 putative substrate binding site [chemical binding]; other site 653045019954 catalytic Zn binding site [ion binding]; other site 653045019955 structural Zn binding site [ion binding]; other site 653045019956 MbtH-like protein; Region: MbtH; cl01279 653045019957 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 653045019958 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 653045019959 substrate binding pocket [chemical binding]; other site 653045019960 chain length determination region; other site 653045019961 substrate-Mg2+ binding site; other site 653045019962 catalytic residues [active] 653045019963 aspartate-rich region 1; other site 653045019964 active site lid residues [active] 653045019965 aspartate-rich region 2; other site 653045019966 CrcB-like protein; Region: CRCB; cl09114 653045019967 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 653045019968 CrcB-like protein; Region: CRCB; cl09114 653045019969 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 653045019970 Helix-turn-helix domains; Region: HTH; cl00088 653045019971 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045019972 dimerization interface [polypeptide binding]; other site 653045019973 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019974 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045019975 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045019976 DNA binding residues [nucleotide binding] 653045019977 dimerization interface [polypeptide binding]; other site 653045019978 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045019979 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 653045019980 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 653045019981 AMP-binding enzyme; Region: AMP-binding; cl15778 653045019982 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 653045019983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045019984 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045019985 Walker A/P-loop; other site 653045019986 ATP binding site [chemical binding]; other site 653045019987 Q-loop/lid; other site 653045019988 ABC transporter signature motif; other site 653045019989 Walker B; other site 653045019990 D-loop; other site 653045019991 H-loop/switch region; other site 653045019992 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045019993 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045019994 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045019995 NB-ARC domain; Region: NB-ARC; pfam00931 653045019996 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045019997 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045019998 binding surface 653045019999 TPR motif; other site 653045020000 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045020001 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045020002 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045020003 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045020004 binding surface 653045020005 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045020006 TPR motif; other site 653045020007 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045020008 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045020009 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045020010 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 653045020011 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045020012 non-specific DNA binding site [nucleotide binding]; other site 653045020013 salt bridge; other site 653045020014 sequence-specific DNA binding site [nucleotide binding]; other site 653045020015 Erythronolide synthase docking; Region: Docking; pfam08990 653045020016 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020017 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020018 active site 653045020019 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020020 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020021 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020022 putative NADP binding site [chemical binding]; other site 653045020023 active site 653045020024 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020025 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020026 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020027 active site 653045020028 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020029 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020030 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020031 putative NADP binding site [chemical binding]; other site 653045020032 active site 653045020033 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020034 Thioesterase; Region: PKS_TE; smart00824 653045020035 Erythronolide synthase docking; Region: Docking; pfam08990 653045020036 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020037 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020038 active site 653045020039 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020040 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020041 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020042 putative NADP binding site [chemical binding]; other site 653045020043 active site 653045020044 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020045 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020046 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020047 active site 653045020048 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020049 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020050 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020051 Enoylreductase; Region: PKS_ER; smart00829 653045020052 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 653045020053 NAD(P) binding site [chemical binding]; other site 653045020054 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020055 putative NADP binding site [chemical binding]; other site 653045020056 active site 653045020057 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020058 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020059 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020060 active site 653045020061 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020062 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020064 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020065 putative NADP binding site [chemical binding]; other site 653045020066 active site 653045020067 acyl-CoA synthetase; Validated; Region: PRK06060 653045020068 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020069 Erythronolide synthase docking; Region: Docking; pfam08990 653045020070 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020071 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020072 active site 653045020073 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020074 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020075 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020076 NADP binding site [chemical binding]; other site 653045020077 active site 653045020078 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020079 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020080 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020081 active site 653045020082 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020083 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020084 NADP binding site [chemical binding]; other site 653045020085 active site 653045020086 acyl-CoA synthetase; Validated; Region: PRK06060 653045020087 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020088 Erythronolide synthase docking; Region: Docking; pfam08990 653045020089 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020090 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020091 active site 653045020092 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020093 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020094 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020095 putative NADP binding site [chemical binding]; other site 653045020096 active site 653045020097 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020098 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020099 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020100 active site 653045020101 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020102 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020103 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020104 putative NADP binding site [chemical binding]; other site 653045020105 active site 653045020106 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020107 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020108 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020109 active site 653045020110 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020111 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020112 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020113 putative NADP binding site [chemical binding]; other site 653045020114 active site 653045020115 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020116 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020117 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020118 active site 653045020119 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020120 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020121 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020122 putative NADP binding site [chemical binding]; other site 653045020123 active site 653045020124 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020125 Erythronolide synthase docking; Region: Docking; pfam08990 653045020126 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020127 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020128 active site 653045020129 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020130 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020131 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020132 NADP binding site [chemical binding]; other site 653045020133 active site 653045020134 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020135 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020136 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020137 active site 653045020138 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020139 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020140 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020141 putative NADP binding site [chemical binding]; other site 653045020142 active site 653045020143 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020144 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020145 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020146 active site 653045020147 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020148 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020149 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020150 putative NADP binding site [chemical binding]; other site 653045020151 active site 653045020152 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020153 Erythronolide synthase docking; Region: Docking; pfam08990 653045020154 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020155 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020156 active site 653045020157 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020158 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020159 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020160 NADP binding site [chemical binding]; other site 653045020161 active site 653045020162 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020163 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020164 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020165 active site 653045020166 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020167 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020168 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020169 putative NADP binding site [chemical binding]; other site 653045020170 active site 653045020171 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020172 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020173 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020174 active site 653045020175 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020176 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020177 NADP binding site [chemical binding]; other site 653045020178 active site 653045020179 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020180 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020181 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020182 active site 653045020183 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020184 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020185 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020186 putative NADP binding site [chemical binding]; other site 653045020187 active site 653045020188 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020189 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020190 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020191 active site 653045020192 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020193 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020194 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020195 NADP binding site [chemical binding]; other site 653045020196 active site 653045020197 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020198 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020199 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020200 active site 653045020201 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020202 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020203 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020204 putative NADP binding site [chemical binding]; other site 653045020205 active site 653045020206 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020207 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020208 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020209 active site 653045020210 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020211 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020212 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020213 putative NADP binding site [chemical binding]; other site 653045020214 active site 653045020215 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020216 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020217 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020218 active site 653045020219 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020220 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020221 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020222 NADP binding site [chemical binding]; other site 653045020223 active site 653045020224 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020225 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020226 NADP binding site [chemical binding]; other site 653045020227 active site 653045020228 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020229 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 653045020230 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020231 active site 653045020232 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020233 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 653045020234 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 3, complex (x); Region: KR_3_FAS_SDR_x; cd08956 653045020235 putative NADP binding site [chemical binding]; other site 653045020236 active site 653045020237 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020238 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020239 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020240 active site 653045020241 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020242 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020243 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020244 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020245 NADP binding site [chemical binding]; other site 653045020246 active site 653045020247 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020248 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020249 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020250 active site 653045020251 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020252 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020253 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020254 NADP binding site [chemical binding]; other site 653045020255 active site 653045020256 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020257 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020258 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020259 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020260 active site 653045020261 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020262 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020263 ketoreductase (KR), subgroup 1, complex (x) SDRs; Region: KR_1_SDR_x; cd08952 653045020264 NADP binding site [chemical binding]; other site 653045020265 active site 653045020266 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020267 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 653045020268 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 653045020269 active site 653045020270 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020271 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020272 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020273 Predicted membrane protein [Function unknown]; Region: COG3428 653045020274 Bacterial PH domain; Region: DUF304; cl01348 653045020275 Bacterial PH domain; Region: DUF304; cl01348 653045020276 Bacterial PH domain; Region: DUF304; cl01348 653045020277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 653045020278 Histidine kinase; Region: HisKA_3; pfam07730 653045020279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045020280 ATP binding site [chemical binding]; other site 653045020281 Mg2+ binding site [ion binding]; other site 653045020282 G-X-G motif; other site 653045020283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045020284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045020285 active site 653045020286 phosphorylation site [posttranslational modification] 653045020287 intermolecular recognition site; other site 653045020288 dimerization interface [polypeptide binding]; other site 653045020289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045020290 DNA binding residues [nucleotide binding] 653045020291 dimerization interface [polypeptide binding]; other site 653045020292 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045020293 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 653045020294 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045020295 DNA binding residues [nucleotide binding] 653045020296 dimerization interface [polypeptide binding]; other site 653045020297 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 653045020298 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045020299 Fusaric acid resistance protein-like; Region: FUSC_2; cl15844 653045020300 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 653045020301 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 653045020302 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 653045020303 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045020304 tetrameric interface [polypeptide binding]; other site 653045020305 NAD binding site [chemical binding]; other site 653045020306 catalytic residues [active] 653045020307 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 653045020308 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 653045020309 PYR/PP interface [polypeptide binding]; other site 653045020310 dimer interface [polypeptide binding]; other site 653045020311 TPP binding site [chemical binding]; other site 653045020312 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 653045020313 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 653045020314 TPP-binding site; other site 653045020315 KduI/IolB family; Region: KduI; cl01508 653045020316 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045020317 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 653045020318 substrate binding site [chemical binding]; other site 653045020319 ATP binding site [chemical binding]; other site 653045020320 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 653045020321 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 653045020322 putative ligand binding site [chemical binding]; other site 653045020323 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045020324 TM-ABC transporter signature motif; other site 653045020325 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 653045020326 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045020327 Walker A/P-loop; other site 653045020328 ATP binding site [chemical binding]; other site 653045020329 Q-loop/lid; other site 653045020330 ABC transporter signature motif; other site 653045020331 Walker B; other site 653045020332 D-loop; other site 653045020333 H-loop/switch region; other site 653045020334 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045020335 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045020336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020337 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045020338 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 653045020339 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045020340 Helix-turn-helix domains; Region: HTH; cl00088 653045020341 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 653045020342 metal-binding site [ion binding] 653045020343 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 653045020344 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 653045020345 metal-binding site [ion binding] 653045020346 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 653045020347 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045020348 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 653045020349 dimer interface [polypeptide binding]; other site 653045020350 Citrate synthase; Region: Citrate_synt; pfam00285 653045020351 active site 653045020352 citrylCoA binding site [chemical binding]; other site 653045020353 NADH binding [chemical binding]; other site 653045020354 cationic pore residues; other site 653045020355 oxalacetate/citrate binding site [chemical binding]; other site 653045020356 coenzyme A binding site [chemical binding]; other site 653045020357 catalytic triad [active] 653045020358 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 653045020359 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045020360 Family description; Region: UvrD_C_2; cl15862 653045020361 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045020362 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045020363 DNA binding site [nucleotide binding] 653045020364 domain linker motif; other site 653045020365 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045020366 dimerization interface [polypeptide binding]; other site 653045020367 ligand binding site [chemical binding]; other site 653045020368 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 653045020369 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045020370 Walker A/P-loop; other site 653045020371 ATP binding site [chemical binding]; other site 653045020372 Q-loop/lid; other site 653045020373 ABC transporter signature motif; other site 653045020374 Walker B; other site 653045020375 D-loop; other site 653045020376 H-loop/switch region; other site 653045020377 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 653045020378 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 653045020379 TM-ABC transporter signature motif; other site 653045020380 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 653045020381 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 653045020382 ligand binding site [chemical binding]; other site 653045020383 dimerization interface [polypeptide binding]; other site 653045020384 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 653045020385 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 653045020386 substrate binding site [chemical binding]; other site 653045020387 dimer interface [polypeptide binding]; other site 653045020388 ATP binding site [chemical binding]; other site 653045020389 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 653045020390 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045020391 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045020392 DNA binding residues [nucleotide binding] 653045020393 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 653045020394 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045020395 substrate binding pocket [chemical binding]; other site 653045020396 catalytic triad [active] 653045020397 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045020398 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045020399 salt bridge; other site 653045020400 non-specific DNA binding site [nucleotide binding]; other site 653045020401 sequence-specific DNA binding site [nucleotide binding]; other site 653045020402 OsmC-like protein; Region: OsmC; cl00767 653045020403 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 653045020404 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 653045020405 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 653045020406 catalytic residue [active] 653045020407 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045020408 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045020409 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045020410 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045020411 dimer interface [polypeptide binding]; other site 653045020412 conserved gate region; other site 653045020413 putative PBP binding loops; other site 653045020414 ABC-ATPase subunit interface; other site 653045020415 ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176 653045020416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045020417 dimer interface [polypeptide binding]; other site 653045020418 conserved gate region; other site 653045020419 putative PBP binding loops; other site 653045020420 ABC-ATPase subunit interface; other site 653045020421 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045020422 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045020423 Cupin domain; Region: Cupin_2; cl09118 653045020424 Methane oxygenase PmoA; Region: PmoA; pfam14100 653045020425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020426 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 653045020427 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045020428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045020429 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045020430 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045020431 dimerization interface [polypeptide binding]; other site 653045020432 ligand binding site [chemical binding]; other site 653045020433 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045020434 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371 653045020435 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 653045020436 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045020437 sugar binding site [chemical binding]; other site 653045020438 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045020439 sugar binding site [chemical binding]; other site 653045020440 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045020441 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045020442 non-specific DNA binding site [nucleotide binding]; other site 653045020443 salt bridge; other site 653045020444 sequence-specific DNA binding site [nucleotide binding]; other site 653045020445 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045020446 non-specific DNA binding site [nucleotide binding]; other site 653045020447 salt bridge; other site 653045020448 sequence-specific DNA binding site [nucleotide binding]; other site 653045020449 Helix-turn-helix domains; Region: HTH; cl00088 653045020450 Predicted acetyltransferase [General function prediction only]; Region: COG3153 653045020451 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045020452 Coenzyme A binding pocket [chemical binding]; other site 653045020453 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 653045020454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045020455 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045020456 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 653045020457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045020458 S-adenosylmethionine binding site [chemical binding]; other site 653045020459 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045020460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045020461 active site 653045020462 catalytic tetrad [active] 653045020463 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045020464 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 653045020465 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 653045020466 EamA-like transporter family; Region: EamA; cl01037 653045020467 EamA-like transporter family; Region: EamA; cl01037 653045020468 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 653045020469 Helix-turn-helix domains; Region: HTH; cl00088 653045020470 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045020471 putative dimerization interface [polypeptide binding]; other site 653045020472 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045020473 glycosyltransferase, MGT family; Region: MGT; TIGR01426 653045020474 active site 653045020475 TDP-binding site; other site 653045020476 acceptor substrate-binding pocket; other site 653045020477 homodimer interface [polypeptide binding]; other site 653045020478 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 653045020479 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 653045020480 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045020481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020482 NAD(P) binding site [chemical binding]; other site 653045020483 active site 653045020484 Serine carboxypeptidase S28; Region: Peptidase_S28; cl15279 653045020485 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 653045020486 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045020487 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045020488 Walker A/P-loop; other site 653045020489 ATP binding site [chemical binding]; other site 653045020490 Q-loop/lid; other site 653045020491 ABC transporter signature motif; other site 653045020492 Walker B; other site 653045020493 D-loop; other site 653045020494 H-loop/switch region; other site 653045020495 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045020496 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 653045020497 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045020498 Walker A/P-loop; other site 653045020499 ATP binding site [chemical binding]; other site 653045020500 Q-loop/lid; other site 653045020501 ABC transporter signature motif; other site 653045020502 Walker B; other site 653045020503 D-loop; other site 653045020504 H-loop/switch region; other site 653045020505 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 653045020506 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045020507 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 653045020508 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 653045020509 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 653045020510 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 653045020511 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045020512 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045020513 active site 653045020514 phosphorylation site [posttranslational modification] 653045020515 intermolecular recognition site; other site 653045020516 dimerization interface [polypeptide binding]; other site 653045020517 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045020518 DNA binding residues [nucleotide binding] 653045020519 dimerization interface [polypeptide binding]; other site 653045020520 Histidine kinase; Region: HisKA_3; pfam07730 653045020521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045020522 Acyltransferase family; Region: Acyl_transf_3; pfam01757 653045020523 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 653045020524 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 653045020525 Zn binding site [ion binding]; other site 653045020526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045020527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045020528 active site 653045020529 phosphorylation site [posttranslational modification] 653045020530 intermolecular recognition site; other site 653045020531 dimerization interface [polypeptide binding]; other site 653045020532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045020533 DNA binding site [nucleotide binding] 653045020534 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045020535 sensor kinase CusS; Provisional; Region: PRK09835 653045020536 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045020537 dimer interface [polypeptide binding]; other site 653045020538 phosphorylation site [posttranslational modification] 653045020539 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045020540 ATP binding site [chemical binding]; other site 653045020541 Mg2+ binding site [ion binding]; other site 653045020542 G-X-G motif; other site 653045020543 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 653045020544 putative catalytic site [active] 653045020545 putative phosphate binding site [ion binding]; other site 653045020546 putative metal binding site [ion binding]; other site 653045020547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045020548 dimerization interface [polypeptide binding]; other site 653045020549 putative DNA binding site [nucleotide binding]; other site 653045020550 putative Zn2+ binding site [ion binding]; other site 653045020551 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045020552 DNA-binding site [nucleotide binding]; DNA binding site 653045020553 RNA-binding motif; other site 653045020554 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 653045020555 DEAD-like helicases superfamily; Region: DEXDc; smart00487 653045020556 ATP binding site [chemical binding]; other site 653045020557 Mg++ binding site [ion binding]; other site 653045020558 motif III; other site 653045020559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045020560 nucleotide binding region [chemical binding]; other site 653045020561 ATP-binding site [chemical binding]; other site 653045020562 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 653045020563 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 653045020564 active site 653045020565 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 653045020566 catalytic triad [active] 653045020567 dimer interface [polypeptide binding]; other site 653045020568 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045020569 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045020570 active site 653045020571 Helix-turn-helix domains; Region: HTH; cl00088 653045020572 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 653045020573 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045020574 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 653045020575 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 653045020576 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 653045020577 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 653045020578 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 653045020579 carboxyltransferase (CT) interaction site; other site 653045020580 biotinylation site [posttranslational modification]; other site 653045020581 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 653045020582 active site 653045020583 catalytic residues [active] 653045020584 metal binding site [ion binding]; metal-binding site 653045020585 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045020586 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045020587 active site 653045020588 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045020589 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 653045020590 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 653045020591 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 653045020592 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 653045020593 active site 653045020594 Short C-terminal domain; Region: SHOCT; cl01373 653045020595 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 653045020596 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 653045020597 glutaminase active site [active] 653045020598 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 653045020599 dimer interface [polypeptide binding]; other site 653045020600 active site 653045020601 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 653045020602 dimer interface [polypeptide binding]; other site 653045020603 active site 653045020604 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 653045020605 Ligand Binding Site [chemical binding]; other site 653045020606 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045020607 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045020608 conserved cys residue [active] 653045020609 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 653045020610 catalytic site [active] 653045020611 putative active site [active] 653045020612 putative substrate binding site [chemical binding]; other site 653045020613 dimer interface [polypeptide binding]; other site 653045020614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045020615 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045020616 active site 653045020617 metal binding site [ion binding]; metal-binding site 653045020618 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 653045020619 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045020620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045020621 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045020622 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045020623 Phosphotransferase enzyme family; Region: APH; pfam01636 653045020624 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045020625 active site 653045020626 ATP binding site [chemical binding]; other site 653045020627 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 653045020628 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045020629 DNA binding residues [nucleotide binding] 653045020630 putative dimer interface [polypeptide binding]; other site 653045020631 Helix-turn-helix domains; Region: HTH; cl00088 653045020632 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045020633 anti sigma factor interaction site; other site 653045020634 regulatory phosphorylation site [posttranslational modification]; other site 653045020635 Clp amino terminal domain; Region: Clp_N; pfam02861 653045020636 Clp amino terminal domain; Region: Clp_N; pfam02861 653045020637 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045020638 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045020639 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 653045020640 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045020641 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045020642 DNA binding site [nucleotide binding] 653045020643 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 653045020644 putative ligand binding site [chemical binding]; other site 653045020645 putative dimerization interface [polypeptide binding]; other site 653045020646 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 653045020647 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045020648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045020649 dimer interface [polypeptide binding]; other site 653045020650 conserved gate region; other site 653045020651 putative PBP binding loops; other site 653045020652 ABC-ATPase subunit interface; other site 653045020653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045020654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045020655 dimer interface [polypeptide binding]; other site 653045020656 conserved gate region; other site 653045020657 putative PBP binding loops; other site 653045020658 ABC-ATPase subunit interface; other site 653045020659 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 653045020660 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 653045020661 heme bH binding site [chemical binding]; other site 653045020662 Qi binding site; other site 653045020663 intrachain domain interface; other site 653045020664 heme bL binding site [chemical binding]; other site 653045020665 interchain domain interface [polypeptide binding]; other site 653045020666 Qo binding site; other site 653045020667 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 653045020668 active site 653045020669 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045020670 dimerization interface [polypeptide binding]; other site 653045020671 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045020672 dimer interface [polypeptide binding]; other site 653045020673 phosphorylation site [posttranslational modification] 653045020674 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045020675 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045020676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045020677 active site 653045020678 phosphorylation site [posttranslational modification] 653045020679 intermolecular recognition site; other site 653045020680 dimerization interface [polypeptide binding]; other site 653045020681 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045020682 DNA binding site [nucleotide binding] 653045020683 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045020684 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045020685 catalytic core [active] 653045020686 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 653045020687 active site 653045020688 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045020689 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 653045020690 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020691 NAD(P) binding site [chemical binding]; other site 653045020692 active site 653045020693 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045020694 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045020695 conserved cys residue [active] 653045020696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045020697 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045020698 hypothetical protein; Provisional; Region: PRK06185 653045020699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020701 Helix-turn-helix domains; Region: HTH; cl00088 653045020702 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045020703 MoeZ/MoeB domain; Region: MoeZ_MoeB; cl14816 653045020704 bacteriocin biosynthesis docking scaffold, SagD family; Region: docking_ocin; cl09146 653045020705 YcaO-like family; Region: YcaO; pfam02624 653045020706 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045020707 Histidine kinase; Region: HisKA_3; pfam07730 653045020708 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045020709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045020710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045020711 active site 653045020712 phosphorylation site [posttranslational modification] 653045020713 intermolecular recognition site; other site 653045020714 dimerization interface [polypeptide binding]; other site 653045020715 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045020716 DNA binding residues [nucleotide binding] 653045020717 dimerization interface [polypeptide binding]; other site 653045020718 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 653045020719 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045020720 PAS domain S-box; Region: sensory_box; TIGR00229 653045020721 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 653045020722 metal binding site [ion binding]; metal-binding site 653045020723 active site 653045020724 I-site; other site 653045020725 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 653045020726 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 653045020727 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045020728 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 653045020729 Phosphoesterase family; Region: Phosphoesterase; cl15450 653045020730 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 653045020731 Imelysin; Region: Peptidase_M75; cl09159 653045020732 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 653045020733 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 653045020734 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 653045020735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020736 putative amidase; Provisional; Region: PRK06169 653045020737 Amidase; Region: Amidase; cl11426 653045020738 Cyclophilin-like; Region: Cyclophil_like; cl00950 653045020739 ectoine/hydroxyectoine ABC transporter solute-binding protein; Region: ectoine_ehuB; TIGR02995 653045020740 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045020741 substrate binding pocket [chemical binding]; other site 653045020742 membrane-bound complex binding site; other site 653045020743 hinge residues; other site 653045020744 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 653045020745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045020746 dimer interface [polypeptide binding]; other site 653045020747 conserved gate region; other site 653045020748 putative PBP binding loops; other site 653045020749 ABC-ATPase subunit interface; other site 653045020750 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 653045020751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045020752 dimer interface [polypeptide binding]; other site 653045020753 conserved gate region; other site 653045020754 putative PBP binding loops; other site 653045020755 ABC-ATPase subunit interface; other site 653045020756 ectoine/hydroxyectoine ABC transporter, ATP-binding protein; Region: ectoine_ehuA; TIGR03005 653045020757 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 653045020758 Walker A/P-loop; other site 653045020759 ATP binding site [chemical binding]; other site 653045020760 Q-loop/lid; other site 653045020761 ABC transporter signature motif; other site 653045020762 Walker B; other site 653045020763 D-loop; other site 653045020764 H-loop/switch region; other site 653045020765 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045020766 Helix-turn-helix domains; Region: HTH; cl00088 653045020767 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045020768 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045020769 putative active site [active] 653045020770 Uncharacterized conserved protein (DUF2277); Region: DUF2277; cl02349 653045020771 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 653045020772 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045020773 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045020774 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045020775 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 653045020776 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 653045020777 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045020778 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 653045020779 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 653045020780 carboxyltransferase (CT) interaction site; other site 653045020781 biotinylation site [posttranslational modification]; other site 653045020782 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045020783 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045020784 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045020785 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045020786 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 653045020787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020788 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 653045020789 NAD(P) binding site [chemical binding]; other site 653045020790 active site 653045020791 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 653045020792 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045020793 active site 2 [active] 653045020794 active site 1 [active] 653045020795 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020796 Acyl transferase domain; Region: Acyl_transf_1; cl08282 653045020797 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 653045020798 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045020799 active site 653045020800 classical (c) SDRs; Region: SDR_c; cd05233 653045020801 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 653045020802 NAD(P) binding site [chemical binding]; other site 653045020803 active site 653045020804 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045020805 active site 653045020806 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 653045020807 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 653045020808 dimer interface [polypeptide binding]; other site 653045020809 active site 653045020810 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045020811 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045020812 active site 653045020813 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 653045020814 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045020815 active site 653045020816 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 653045020817 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 653045020818 dimer interface [polypeptide binding]; other site 653045020819 active site 653045020820 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045020821 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045020822 dimerization interface [polypeptide binding]; other site 653045020823 DNA binding residues [nucleotide binding] 653045020824 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045020825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045020826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045020827 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 653045020828 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045020829 NAD(P) binding site [chemical binding]; other site 653045020830 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 653045020831 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045020832 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 653045020833 NMT1/THI5 like; Region: NMT1; pfam09084 653045020834 substrate binding pocket [chemical binding]; other site 653045020835 membrane-bound complex binding site; other site 653045020836 hinge residues; other site 653045020837 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 653045020838 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045020839 putative PBP binding loops; other site 653045020840 ABC-ATPase subunit interface; other site 653045020841 Helix-turn-helix domains; Region: HTH; cl00088 653045020842 Helix-turn-helix domains; Region: HTH; cl00088 653045020843 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045020844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045020845 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045020846 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045020847 Chitin binding domain; Region: Chitin_bind_3; cl03871 653045020848 Helix-turn-helix domains; Region: HTH; cl00088 653045020849 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 653045020850 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 653045020851 Protein of unknown function, DUF642; Region: DUF642; pfam04862 653045020852 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045020853 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 653045020854 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045020855 non-specific DNA binding site [nucleotide binding]; other site 653045020856 salt bridge; other site 653045020857 sequence-specific DNA binding site [nucleotide binding]; other site 653045020858 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045020859 Transcriptional regulators [Transcription]; Region: FadR; COG2186 653045020860 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045020861 DNA-binding site [nucleotide binding]; DNA binding site 653045020862 FCD domain; Region: FCD; cl11656 653045020863 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045020864 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045020865 C-terminal Early set domain associated with the catalytic domain of galactose oxidase; Region: E_set_GO_C; cd02851 653045020866 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 653045020867 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 653045020868 active site 653045020869 putative catalytic site [active] 653045020870 UMP phosphatase; Provisional; Region: PRK10444 653045020871 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045020872 active site 653045020873 motif I; other site 653045020874 motif II; other site 653045020875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045020876 active site 653045020877 motif I; other site 653045020878 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 653045020879 Helix-turn-helix domains; Region: HTH; cl00088 653045020880 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045020881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045020882 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 653045020883 Domain of unknown function (DUF336); Region: DUF336; cl01249 653045020884 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 653045020885 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 653045020886 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 653045020887 active site 653045020888 catalytic site [active] 653045020889 Protein of unknown function (DUF445); Region: DUF445; pfam04286 653045020890 SGNH_hydrolase subfamily, similar to the putative arylesterase/acylhydrolase from the rumen anaerobe Prevotella bryantii XynE. The P. bryantii XynE gene is located in a xylanase gene cluster. SGNH hydrolases are a diverse family of lipases and esterases; Region: XynE_like; cd01830 653045020891 active site 653045020892 catalytic triad [active] 653045020893 oxyanion hole [active] 653045020894 Domain of unknown function (DUF1707); Region: DUF1707; pfam08044 653045020895 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 653045020896 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045020897 Walker A/P-loop; other site 653045020898 ATP binding site [chemical binding]; other site 653045020899 Q-loop/lid; other site 653045020900 ABC transporter signature motif; other site 653045020901 Walker B; other site 653045020902 D-loop; other site 653045020903 H-loop/switch region; other site 653045020904 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 653045020905 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 653045020906 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 653045020907 Transglycosylase; Region: Transgly; cl07896 653045020908 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 653045020909 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045020910 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 653045020911 oligomerisation interface [polypeptide binding]; other site 653045020912 mobile loop; other site 653045020913 roof hairpin; other site 653045020914 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 653045020915 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 653045020916 catalytic triad [active] 653045020917 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 653045020918 active site 653045020919 dimerization interface [polypeptide binding]; other site 653045020920 ribonuclease PH; Reviewed; Region: rph; PRK00173 653045020921 Ribonuclease PH; Region: RNase_PH_bact; cd11362 653045020922 hexamer interface [polypeptide binding]; other site 653045020923 active site 653045020924 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 653045020925 active site turn [active] 653045020926 phosphorylation site [posttranslational modification] 653045020927 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 653045020928 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 653045020929 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045020930 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 653045020931 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 653045020932 dimer interface [polypeptide binding]; other site 653045020933 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045020934 catalytic residue [active] 653045020935 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 653045020936 MoaE interaction surface [polypeptide binding]; other site 653045020937 MoeB interaction surface [polypeptide binding]; other site 653045020938 thiocarboxylated glycine; other site 653045020939 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 653045020940 MPN+ (JAMM) motif; other site 653045020941 Zinc-binding site [ion binding]; other site 653045020942 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 653045020943 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 653045020944 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 653045020945 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 653045020946 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 653045020947 active site 653045020948 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 653045020949 Isochorismatase family; Region: Isochorismatase; pfam00857 653045020950 catalytic triad [active] 653045020951 metal binding site [ion binding]; metal-binding site 653045020952 conserved cis-peptide bond; other site 653045020953 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 653045020954 RDD family; Region: RDD; cl00746 653045020955 RDD family; Region: RDD; cl00746 653045020956 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 653045020957 RDD family; Region: RDD; cl00746 653045020958 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045020959 salt bridge; other site 653045020960 non-specific DNA binding site [nucleotide binding]; other site 653045020961 sequence-specific DNA binding site [nucleotide binding]; other site 653045020962 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 653045020963 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 653045020964 putative NAD(P) binding site [chemical binding]; other site 653045020965 putative substrate binding site [chemical binding]; other site 653045020966 catalytic Zn binding site [ion binding]; other site 653045020967 structural Zn binding site [ion binding]; other site 653045020968 dimer interface [polypeptide binding]; other site 653045020969 FAD binding domain; Region: FAD_binding_4; pfam01565 653045020970 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 653045020971 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 653045020972 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 653045020973 dimer interface [polypeptide binding]; other site 653045020974 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 653045020975 active site 653045020976 Fe binding site [ion binding]; other site 653045020977 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045020978 Helix-turn-helix domains; Region: HTH; cl00088 653045020979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045020980 dimerization interface [polypeptide binding]; other site 653045020981 putative DNA binding site [nucleotide binding]; other site 653045020982 putative Zn2+ binding site [ion binding]; other site 653045020983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045020984 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045020985 putative substrate translocation pore; other site 653045020986 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 653045020987 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 653045020988 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045020989 Helix-turn-helix domains; Region: HTH; cl00088 653045020990 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 653045020991 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045020992 ATP binding site [chemical binding]; other site 653045020993 putative Mg++ binding site [ion binding]; other site 653045020994 Fic/DOC family; Region: Fic; cl00960 653045020995 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045020996 putative substrate translocation pore; other site 653045020997 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045020998 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 653045020999 Cysteine dioxygenase type I; Region: CDO_I; cl15835 653045021000 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045021001 Helix-turn-helix domains; Region: HTH; cl00088 653045021002 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_6; cd08423 653045021003 putative dimerization interface [polypeptide binding]; other site 653045021004 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045021005 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 653045021006 AMP-binding enzyme; Region: AMP-binding; cl15778 653045021007 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045021008 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 653045021009 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 653045021010 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 653045021011 4-hydroxybenzoyl-CoA reductase, gamma subunit; Region: 4hydroxCoAred; TIGR03193 653045021012 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 653045021013 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 653045021014 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 653045021015 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 653045021016 active site 653045021017 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045021018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021019 dimer interface [polypeptide binding]; other site 653045021020 conserved gate region; other site 653045021021 putative PBP binding loops; other site 653045021022 ABC-ATPase subunit interface; other site 653045021023 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021024 dimer interface [polypeptide binding]; other site 653045021025 conserved gate region; other site 653045021026 putative PBP binding loops; other site 653045021027 ABC-ATPase subunit interface; other site 653045021028 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 653045021029 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045021030 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 653045021031 catalytic residues [active] 653045021032 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 653045021033 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 653045021034 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 653045021035 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 653045021036 hinge; other site 653045021037 active site 653045021038 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 653045021039 IHF dimer interface [polypeptide binding]; other site 653045021040 IHF - DNA interface [nucleotide binding]; other site 653045021041 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 653045021042 Malic enzyme, N-terminal domain; Region: malic; pfam00390 653045021043 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 653045021044 putative NAD(P) binding site [chemical binding]; other site 653045021045 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045021046 DNA-binding site [nucleotide binding]; DNA binding site 653045021047 RNA-binding motif; other site 653045021048 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 653045021049 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021050 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 653045021051 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021052 Family description; Region: UvrD_C_2; cl15862 653045021053 Putative zinc-finger; Region: zf-HC2; cl15806 653045021054 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 653045021055 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045021056 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045021057 DNA binding residues [nucleotide binding] 653045021058 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 653045021059 CGNR zinc finger; Region: zf-CGNR; pfam11706 653045021060 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 653045021061 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 653045021062 active site 653045021063 Helix-turn-helix domains; Region: HTH; cl00088 653045021064 DNA binding site [nucleotide binding] 653045021065 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 653045021066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045021067 putative substrate translocation pore; other site 653045021068 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045021069 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045021070 DNA binding residues [nucleotide binding] 653045021071 DEAD-like helicases superfamily; Region: DEXDc; smart00487 653045021072 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021073 ATP binding site [chemical binding]; other site 653045021074 putative Mg++ binding site [ion binding]; other site 653045021075 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045021076 nucleotide binding region [chemical binding]; other site 653045021077 ATP-binding site [chemical binding]; other site 653045021078 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045021079 DNA-binding site [nucleotide binding]; DNA binding site 653045021080 RNA-binding motif; other site 653045021081 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045021082 Helix-turn-helix domains; Region: HTH; cl00088 653045021083 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045021084 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045021085 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045021086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021087 dimer interface [polypeptide binding]; other site 653045021088 conserved gate region; other site 653045021089 putative PBP binding loops; other site 653045021090 ABC-ATPase subunit interface; other site 653045021091 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045021092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021093 dimer interface [polypeptide binding]; other site 653045021094 conserved gate region; other site 653045021095 putative PBP binding loops; other site 653045021096 ABC-ATPase subunit interface; other site 653045021097 putative alpha-glucosidase; Provisional; Region: PRK10658 653045021098 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 653045021099 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 653045021100 active site 653045021101 homotrimer interface [polypeptide binding]; other site 653045021102 catalytic site [active] 653045021103 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 653045021104 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045021105 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 653045021106 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 653045021107 Helix-turn-helix domains; Region: HTH; cl00088 653045021108 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR4; cd08270 653045021109 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045021110 putative NAD(P) binding site [chemical binding]; other site 653045021111 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045021112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021113 active site 653045021114 NAD+ binding site [chemical binding]; other site 653045021115 oligomerization interface [polypeptide binding]; other site 653045021116 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 653045021117 nudix motif; other site 653045021118 Helix-turn-helix domains; Region: HTH; cl00088 653045021119 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045021120 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021121 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 653045021122 SmpB-tmRNA interface; other site 653045021123 C-terminal peptidase (prc); Region: prc; TIGR00225 653045021124 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 653045021125 protein binding site [polypeptide binding]; other site 653045021126 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 653045021127 Catalytic dyad [active] 653045021128 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 653045021129 FtsX-like permease family; Region: FtsX; cl15850 653045021130 FtsX-like permease family; Region: FtsX; cl15850 653045021131 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 653045021132 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021133 Walker A/P-loop; other site 653045021134 ATP binding site [chemical binding]; other site 653045021135 Q-loop/lid; other site 653045021136 ABC transporter signature motif; other site 653045021137 Walker B; other site 653045021138 D-loop; other site 653045021139 H-loop/switch region; other site 653045021140 peptide chain release factor 2; Validated; Region: prfB; PRK00578 653045021141 RF-1 domain; Region: RF-1; cl02875 653045021142 RF-1 domain; Region: RF-1; cl02875 653045021143 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045021144 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045021145 active site 653045021146 ATP binding site [chemical binding]; other site 653045021147 substrate binding site [chemical binding]; other site 653045021148 activation loop (A-loop); other site 653045021149 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045021150 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045021151 active site 653045021152 ATP binding site [chemical binding]; other site 653045021153 substrate binding site [chemical binding]; other site 653045021154 activation loop (A-loop); other site 653045021155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045021156 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045021157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045021158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021159 putative PBP binding loops; other site 653045021160 dimer interface [polypeptide binding]; other site 653045021161 ABC-ATPase subunit interface; other site 653045021162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 653045021163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021164 dimer interface [polypeptide binding]; other site 653045021165 conserved gate region; other site 653045021166 putative PBP binding loops; other site 653045021167 ABC-ATPase subunit interface; other site 653045021168 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 653045021169 hydrophobic ligand binding site; other site 653045021170 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045021171 Helix-turn-helix domains; Region: HTH; cl00088 653045021172 WHG domain; Region: WHG; pfam13305 653045021173 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR8; cd08273 653045021174 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045021175 putative NAD(P) binding site [chemical binding]; other site 653045021176 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 653045021177 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045021178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045021179 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045021180 non-specific DNA binding site [nucleotide binding]; other site 653045021181 salt bridge; other site 653045021182 sequence-specific DNA binding site [nucleotide binding]; other site 653045021183 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045021184 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045021185 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045021186 NB-ARC domain; Region: NB-ARC; pfam00931 653045021187 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045021188 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045021189 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 653045021190 binding surface 653045021191 TPR motif; other site 653045021192 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045021193 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045021194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 653045021195 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 653045021196 FeS/SAM binding site; other site 653045021197 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 653045021198 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 653045021199 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045021200 Coenzyme A binding pocket [chemical binding]; other site 653045021201 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045021202 Helix-turn-helix domains; Region: HTH; cl00088 653045021203 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 653045021204 classical (c) SDRs; Region: SDR_c; cd05233 653045021205 NAD(P) binding site [chemical binding]; other site 653045021206 active site 653045021207 Helix-turn-helix domains; Region: HTH; cl00088 653045021208 putative glycosyl transferase; Provisional; Region: PRK10073 653045021209 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 653045021210 active site 653045021211 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 653045021212 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045021213 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 653045021214 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045021215 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 653045021216 active site 653045021217 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 653045021218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 653045021219 active site 653045021220 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 653045021221 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 653045021222 active site 653045021223 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 653045021224 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 653045021225 intracellular protease, PfpI family; Region: PfpI; TIGR01382 653045021226 conserved cys residue [active] 653045021227 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 653045021228 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045021229 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045021230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 653045021231 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 653045021232 Probable transposase; Region: OrfB_IS605; pfam01385 653045021233 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 653045021234 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 653045021235 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 653045021236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045021237 nucleotide binding region [chemical binding]; other site 653045021238 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 653045021239 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045021240 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 653045021241 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045021242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045021243 active site 653045021244 phosphorylation site [posttranslational modification] 653045021245 intermolecular recognition site; other site 653045021246 dimerization interface [polypeptide binding]; other site 653045021247 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045021248 DNA binding residues [nucleotide binding] 653045021249 dimerization interface [polypeptide binding]; other site 653045021250 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 653045021251 30S subunit binding site; other site 653045021252 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 653045021253 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 653045021254 lipoprotein LpqB; Provisional; Region: PRK13613 653045021255 Sporulation and spore germination; Region: Germane; cl11253 653045021256 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 653045021257 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045021258 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045021259 dimer interface [polypeptide binding]; other site 653045021260 phosphorylation site [posttranslational modification] 653045021261 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045021262 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045021263 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045021264 active site 653045021265 phosphorylation site [posttranslational modification] 653045021266 intermolecular recognition site; other site 653045021267 dimerization interface [polypeptide binding]; other site 653045021268 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045021269 DNA binding site [nucleotide binding] 653045021270 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 653045021271 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 653045021272 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 653045021273 Adenosylhomocysteinase; Provisional; Region: PTZ00075 653045021274 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 653045021275 oligomerization interface [polypeptide binding]; other site 653045021276 active site 653045021277 NAD+ binding site [chemical binding]; other site 653045021278 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 653045021279 active site 653045021280 P-loop; other site 653045021281 phosphorylation site [posttranslational modification] 653045021282 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 653045021283 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 653045021284 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 653045021285 active site 653045021286 phosphorylation site [posttranslational modification] 653045021287 Cation efflux family; Region: Cation_efflux; cl00316 653045021288 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 653045021289 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 653045021290 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 653045021291 Trm112p-like protein; Region: Trm112p; cl01066 653045021292 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 653045021293 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 653045021294 active site 653045021295 substrate binding site [chemical binding]; other site 653045021296 metal binding site [ion binding]; metal-binding site 653045021297 glycolate transporter; Provisional; Region: PRK09695 653045021298 L-lactate permease; Region: Lactate_perm; cl00701 653045021299 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 653045021300 Possibl zinc metallo-peptidase; Region: DUF1025; cl01577 653045021301 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045021302 active site 653045021303 Transcription factor WhiB; Region: Whib; pfam02467 653045021304 Cysteine dioxygenase type I; Region: CDO_I; cl15835 653045021305 LPPG:FO 2-phospho-L-lactate transferase; important in F420 biosynthesis; Region: CofD_like; cd07186 653045021306 phosphate binding site [ion binding]; other site 653045021307 dimer interface [polypeptide binding]; other site 653045021308 substrate binding site [chemical binding]; other site 653045021309 F420-0--gamma-glutamyl ligase; Provisional; Region: PRK13294 653045021310 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 653045021311 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 653045021312 putative FMN binding site [chemical binding]; other site 653045021313 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 653045021314 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 653045021315 minor groove reading motif; other site 653045021316 helix-hairpin-helix signature motif; other site 653045021317 substrate binding pocket [chemical binding]; other site 653045021318 active site 653045021319 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 653045021320 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 653045021321 active site 653045021322 Substrate binding site; other site 653045021323 Mg++ binding site; other site 653045021324 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 653045021325 putative trimer interface [polypeptide binding]; other site 653045021326 putative CoA binding site [chemical binding]; other site 653045021327 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 653045021328 amidase catalytic site [active] 653045021329 Zn binding residues [ion binding]; other site 653045021330 substrate binding site [chemical binding]; other site 653045021331 AMP-binding enzyme; Region: AMP-binding; cl15778 653045021332 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045021333 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045021334 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 653045021335 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045021336 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 653045021337 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 653045021338 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 653045021339 Ligand binding site; other site 653045021340 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045021341 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 653045021342 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 653045021343 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045021344 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045021345 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 653045021346 active site 653045021347 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 653045021348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021349 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 653045021350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021351 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 653045021352 active site 653045021353 dimer interface [polypeptide binding]; other site 653045021354 AIR carboxylase; Region: AIRC; cl00310 653045021355 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 653045021356 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045021357 GtrA-like protein; Region: GtrA; cl00971 653045021358 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045021359 dimer interface [polypeptide binding]; other site 653045021360 phosphorylation site [posttranslational modification] 653045021361 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045021362 ATP binding site [chemical binding]; other site 653045021363 Mg2+ binding site [ion binding]; other site 653045021364 G-X-G motif; other site 653045021365 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045021366 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045021367 active site 653045021368 phosphorylation site [posttranslational modification] 653045021369 intermolecular recognition site; other site 653045021370 dimerization interface [polypeptide binding]; other site 653045021371 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045021372 DNA binding site [nucleotide binding] 653045021373 amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924 653045021374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 653045021375 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 653045021376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045021377 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045021378 anti sigma factor interaction site; other site 653045021379 regulatory phosphorylation site [posttranslational modification]; other site 653045021380 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045021381 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045021382 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045021383 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045021384 DNA binding residues [nucleotide binding] 653045021385 imidazolonepropionase; Provisional; Region: PRK14085 653045021386 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 653045021387 active site 653045021388 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 653045021389 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045021390 active site 653045021391 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 653045021392 allantoate amidohydrolase; Reviewed; Region: PRK09290 653045021393 active site 653045021394 metal binding site [ion binding]; metal-binding site 653045021395 dimer interface [polypeptide binding]; other site 653045021396 urocanate hydratase; Provisional; Region: PRK05414 653045021397 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 653045021398 Prostaglandin dehydrogenases; Region: PGDH; cd05288 653045021399 NAD(P) binding site [chemical binding]; other site 653045021400 substrate binding site [chemical binding]; other site 653045021401 dimer interface [polypeptide binding]; other site 653045021402 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 653045021403 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045021404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045021405 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 653045021406 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 653045021407 conserved cys residue [active] 653045021408 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 653045021409 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045021410 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 653045021411 active site 653045021412 DNA binding site [nucleotide binding] 653045021413 Int/Topo IB signature motif; other site 653045021414 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 653045021415 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045021416 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045021417 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 653045021418 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045021419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045021420 Helix-turn-helix domains; Region: HTH; cl00088 653045021421 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 653045021422 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 653045021423 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 653045021424 putative active site [active] 653045021425 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 653045021426 active sites [active] 653045021427 tetramer interface [polypeptide binding]; other site 653045021428 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 653045021429 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 653045021430 Walker A/P-loop; other site 653045021431 ATP binding site [chemical binding]; other site 653045021432 Q-loop/lid; other site 653045021433 ABC transporter signature motif; other site 653045021434 Walker B; other site 653045021435 D-loop; other site 653045021436 H-loop/switch region; other site 653045021437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021438 dimer interface [polypeptide binding]; other site 653045021439 conserved gate region; other site 653045021440 putative PBP binding loops; other site 653045021441 ABC-ATPase subunit interface; other site 653045021442 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021443 dimer interface [polypeptide binding]; other site 653045021444 conserved gate region; other site 653045021445 putative PBP binding loops; other site 653045021446 ABC-ATPase subunit interface; other site 653045021447 NMT1-like family; Region: NMT1_2; cl15260 653045021448 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 653045021449 Sodium:solute symporter family; Region: SSF; cl00456 653045021450 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045021451 Tetratricopeptide repeat; Region: TPR_12; pfam13424 653045021452 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045021453 acyl-CoA synthetase; Validated; Region: PRK07787 653045021454 AMP-binding enzyme; Region: AMP-binding; cl15778 653045021455 AMP-binding enzyme; Region: AMP-binding; cl15778 653045021456 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 653045021457 Integrase core domain; Region: rve; cl01316 653045021458 Winged helix-turn helix; Region: HTH_29; pfam13551 653045021459 Helix-turn-helix domains; Region: HTH; cl00088 653045021460 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 653045021461 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 653045021462 dimer interface [polypeptide binding]; other site 653045021463 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045021464 catalytic residue [active] 653045021465 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 653045021466 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 653045021467 active site 653045021468 catalytic triad [active] 653045021469 oxyanion hole [active] 653045021470 acetyl-CoA acetyltransferase; Provisional; Region: PRK07851 653045021471 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 653045021472 dimer interface [polypeptide binding]; other site 653045021473 active site 653045021474 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 653045021475 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 653045021476 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045021477 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045021478 Walker A/P-loop; other site 653045021479 ATP binding site [chemical binding]; other site 653045021480 Q-loop/lid; other site 653045021481 ABC transporter signature motif; other site 653045021482 Walker B; other site 653045021483 D-loop; other site 653045021484 H-loop/switch region; other site 653045021485 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 653045021486 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045021487 FtsX-like permease family; Region: FtsX; cl15850 653045021488 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045021489 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 653045021490 FtsX-like permease family; Region: FtsX; cl15850 653045021491 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 653045021492 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045021493 S-adenosylmethionine binding site [chemical binding]; other site 653045021494 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 653045021495 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 653045021496 Protein of unknown function (DUF501); Region: DUF501; cl00652 653045021497 Septum formation initiator; Region: DivIC; cl11433 653045021498 enolase; Provisional; Region: eno; PRK00077 653045021499 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 653045021500 dimer interface [polypeptide binding]; other site 653045021501 metal binding site [ion binding]; metal-binding site 653045021502 substrate binding pocket [chemical binding]; other site 653045021503 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 653045021504 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 653045021505 putative peptidoglycan binding site; other site 653045021506 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 653045021507 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045021508 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 653045021509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045021510 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 653045021511 Protein of unknown function (DUF742); Region: DUF742; pfam05331 653045021512 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 653045021513 Conserved hypothetical ATP binding protein; Region: ATP_bind_1; pfam03029 653045021514 G1 box; other site 653045021515 GTP/Mg2+ binding site [chemical binding]; other site 653045021516 G2 box; other site 653045021517 Switch I region; other site 653045021518 G3 box; other site 653045021519 Switch II region; other site 653045021520 G4 box; other site 653045021521 G5 box; other site 653045021522 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045021523 aromatic prenyltransferase, DMATS type; Region: arom_pren_DMATS; cl15444 653045021524 Tryptophan dimethylallyltransferase; Region: Trp_DMAT; pfam11991 653045021525 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 653045021526 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045021527 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045021528 catalytic residue [active] 653045021529 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 653045021530 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 653045021531 Protein of unknown function DUF262; Region: DUF262; cl14890 653045021532 Predicted membrane protein [Function unknown]; Region: COG3463 653045021533 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 653045021534 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045021535 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045021536 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045021537 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045021538 Bacterial Ig-like domain; Region: Big_5; cl01012 653045021539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 653045021540 Bacterial Ig-like domain; Region: Big_5; cl01012 653045021541 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 653045021542 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 653045021543 active sites [active] 653045021544 tetramer interface [polypeptide binding]; other site 653045021545 GAF domain; Region: GAF; cl15785 653045021546 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 653045021547 metal binding site [ion binding]; metal-binding site 653045021548 active site 653045021549 I-site; other site 653045021550 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045021551 enoyl-CoA hydratase; Provisional; Region: PRK07657 653045021552 substrate binding site [chemical binding]; other site 653045021553 oxyanion hole (OAH) forming residues; other site 653045021554 trimer interface [polypeptide binding]; other site 653045021555 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 653045021556 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045021557 cyclase homology domain; Region: CHD; cd07302 653045021558 nucleotidyl binding site; other site 653045021559 metal binding site [ion binding]; metal-binding site 653045021560 dimer interface [polypeptide binding]; other site 653045021561 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 653045021562 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 653045021563 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 653045021564 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 653045021565 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045021566 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045021567 Acyl-CoA carboxylase epsilon subunit; Region: ACC_epsilon; pfam13822 653045021568 Maf-like protein; Region: Maf; pfam02545 653045021569 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 653045021570 active site 653045021571 dimer interface [polypeptide binding]; other site 653045021572 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 653045021573 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 653045021574 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045021575 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 653045021576 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 653045021577 carboxyltransferase (CT) interaction site; other site 653045021578 biotinylation site [posttranslational modification]; other site 653045021579 Predicted esterase [General function prediction only]; Region: COG0627 653045021580 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045021581 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045021582 Helix-turn-helix domains; Region: HTH; cl00088 653045021583 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 653045021584 Helix-turn-helix domains; Region: HTH; cl00088 653045021585 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 653045021586 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 653045021587 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045021588 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045021589 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 653045021590 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 653045021591 putative active site pocket [active] 653045021592 dimerization interface [polypeptide binding]; other site 653045021593 putative catalytic residue [active] 653045021594 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 653045021595 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 653045021596 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 653045021597 active site 653045021598 substrate binding site [chemical binding]; other site 653045021599 metal binding site [ion binding]; metal-binding site 653045021600 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 653045021601 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 653045021602 intersubunit interface [polypeptide binding]; other site 653045021603 active site 653045021604 catalytic residue [active] 653045021605 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 653045021606 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045021607 NAD(P) binding site [chemical binding]; other site 653045021608 catalytic residues [active] 653045021609 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045021610 NAD(P) binding site [chemical binding]; other site 653045021611 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045021612 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 653045021613 2-pyrone-4,6-dicarboxylic acid (PDC) hydrolase hydrolyzes PDC to yield 4-oxalomesaconic acid (OMA) or its tautomer, 4-carboxy-2-hydroxymuconic acid (CHM). This reaction is part of the protocatechuate (PCA) 4,5-cleavage pathway. PCA is one of the most...; Region: PDC_hydrolase; cd01311 653045021614 active site 653045021615 benzoate transport; Region: 2A0115; TIGR00895 653045021616 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045021617 putative substrate translocation pore; other site 653045021618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045021619 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021620 active site 653045021621 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045021622 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045021623 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045021624 DNA binding residues [nucleotide binding] 653045021625 Ycf27; Reviewed; Region: orf27; CHL00148 653045021626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045021627 active site 653045021628 phosphorylation site [posttranslational modification] 653045021629 intermolecular recognition site; other site 653045021630 dimerization interface [polypeptide binding]; other site 653045021631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045021632 DNA binding site [nucleotide binding] 653045021633 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 653045021634 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 653045021635 dimerization interface [polypeptide binding]; other site 653045021636 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045021637 dimer interface [polypeptide binding]; other site 653045021638 phosphorylation site [posttranslational modification] 653045021639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045021640 ATP binding site [chemical binding]; other site 653045021641 Mg2+ binding site [ion binding]; other site 653045021642 G-X-G motif; other site 653045021643 PspC domain; Region: PspC; cl00864 653045021644 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 653045021645 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 653045021646 active site 653045021647 Predicted esterase [General function prediction only]; Region: COG0400 653045021648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045021649 putative substrate translocation pore; other site 653045021650 Helix-turn-helix domains; Region: HTH; cl00088 653045021651 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 653045021652 putative dimerization interface [polypeptide binding]; other site 653045021653 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 653045021654 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 653045021655 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 653045021656 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 653045021657 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 653045021658 active site 653045021659 catalytic motif [active] 653045021660 Zn binding site [ion binding]; other site 653045021661 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 653045021662 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 653045021663 TM-ABC transporter signature motif; other site 653045021664 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 653045021665 TM-ABC transporter signature motif; other site 653045021666 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 653045021667 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 653045021668 Walker A/P-loop; other site 653045021669 ATP binding site [chemical binding]; other site 653045021670 Q-loop/lid; other site 653045021671 ABC transporter signature motif; other site 653045021672 Walker B; other site 653045021673 D-loop; other site 653045021674 H-loop/switch region; other site 653045021675 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 653045021676 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 653045021677 ligand binding site [chemical binding]; other site 653045021678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045021679 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045021680 non-specific DNA binding site [nucleotide binding]; other site 653045021681 salt bridge; other site 653045021682 sequence-specific DNA binding site [nucleotide binding]; other site 653045021683 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 653045021684 amidohydrolase; Region: amidohydrolases; TIGR01891 653045021685 metal binding site [ion binding]; metal-binding site 653045021686 putative dimer interface [polypeptide binding]; other site 653045021687 NeuB family; Region: NeuB; cl00496 653045021688 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 653045021689 ligand binding site; other site 653045021690 tetramer interface; other site 653045021691 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045021692 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 653045021693 active site 653045021694 OpgC protein; Region: OpgC_C; cl00792 653045021695 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 653045021696 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045021697 active site 653045021698 substrate binding site [chemical binding]; other site 653045021699 ATP binding site [chemical binding]; other site 653045021700 CoA-transferase family III; Region: CoA_transf_3; pfam02515 653045021701 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045021702 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 653045021703 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 653045021704 putative NAD(P) binding site [chemical binding]; other site 653045021705 catalytic Zn binding site [ion binding]; other site 653045021706 gluconate 5-dehydrogenase; Provisional; Region: PRK06124 653045021707 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 653045021708 NADP binding site [chemical binding]; other site 653045021709 homodimer interface [polypeptide binding]; other site 653045021710 active site 653045021711 GntP family permease; Region: GntP_permease; pfam02447 653045021712 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 653045021713 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 653045021714 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 653045021715 ATP-binding site [chemical binding]; other site 653045021716 Gluconate-6-phosphate binding site [chemical binding]; other site 653045021717 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045021718 DNA-binding site [nucleotide binding]; DNA binding site 653045021719 FCD domain; Region: FCD; cl11656 653045021720 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 653045021721 putative active site [active] 653045021722 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 653045021723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045021724 Helix-turn-helix domains; Region: HTH; cl00088 653045021725 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_3; cd08436 653045021726 putative dimerization interface [polypeptide binding]; other site 653045021727 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045021728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021729 NAD(P) binding site [chemical binding]; other site 653045021730 active site 653045021731 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045021732 non-specific DNA binding site [nucleotide binding]; other site 653045021733 salt bridge; other site 653045021734 sequence-specific DNA binding site [nucleotide binding]; other site 653045021735 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045021736 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 653045021737 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 653045021738 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 653045021739 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 653045021740 DXD motif; other site 653045021741 amidase; Provisional; Region: PRK06061 653045021742 Amidase; Region: Amidase; cl11426 653045021743 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 653045021744 B3/4 domain; Region: B3_4; cl11458 653045021745 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 653045021746 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 653045021747 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 653045021748 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 653045021749 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 653045021750 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045021751 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045021752 Domain of unknown function (DUF4328); Region: DUF4328; pfam14219 653045021753 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 653045021754 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 653045021755 active site 653045021756 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 653045021757 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 653045021758 putative Iron-sulfur protein interface [polypeptide binding]; other site 653045021759 putative proximal heme binding site [chemical binding]; other site 653045021760 putative SdhD-like interface [polypeptide binding]; other site 653045021761 putative distal heme binding site [chemical binding]; other site 653045021762 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 653045021763 putative Iron-sulfur protein interface [polypeptide binding]; other site 653045021764 putative proximal heme binding site [chemical binding]; other site 653045021765 putative SdhC-like subunit interface [polypeptide binding]; other site 653045021766 putative distal heme binding site [chemical binding]; other site 653045021767 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 653045021768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021769 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 653045021770 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 653045021771 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 653045021772 VanZ like family; Region: VanZ; cl01971 653045021773 RDD family; Region: RDD; cl00746 653045021774 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 653045021775 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 653045021776 putative active site [active] 653045021777 putative metal binding site [ion binding]; other site 653045021778 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 653045021779 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 653045021780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021781 NAD(P) binding site [chemical binding]; other site 653045021782 active site 653045021783 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 653045021784 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 653045021785 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 653045021786 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 653045021787 active site 653045021788 HIGH motif; other site 653045021789 dimer interface [polypeptide binding]; other site 653045021790 KMSKS motif; other site 653045021791 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 653045021792 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 653045021793 dimer interface [polypeptide binding]; other site 653045021794 active site 653045021795 glycine-pyridoxal phosphate binding site [chemical binding]; other site 653045021796 folate binding site [chemical binding]; other site 653045021797 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 653045021798 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 653045021799 inhibitor-cofactor binding pocket; inhibition site 653045021800 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045021801 catalytic residue [active] 653045021802 NMT1-like family; Region: NMT1_2; cl15260 653045021803 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 653045021804 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 653045021805 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045021806 dimer interface [polypeptide binding]; other site 653045021807 conserved gate region; other site 653045021808 putative PBP binding loops; other site 653045021809 ABC-ATPase subunit interface; other site 653045021810 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 653045021811 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021812 choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415 653045021813 Walker A/P-loop; other site 653045021814 ATP binding site [chemical binding]; other site 653045021815 Q-loop/lid; other site 653045021816 ABC transporter signature motif; other site 653045021817 Walker B; other site 653045021818 D-loop; other site 653045021819 H-loop/switch region; other site 653045021820 choline dehydrogenase; Validated; Region: PRK02106 653045021821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021822 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 653045021823 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 653045021824 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045021825 NAD(P) binding site [chemical binding]; other site 653045021826 catalytic residues [active] 653045021827 malate dehydrogenase; Provisional; Region: PRK05442 653045021828 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 653045021829 NAD(P) binding site [chemical binding]; other site 653045021830 dimer interface [polypeptide binding]; other site 653045021831 malate binding site [chemical binding]; other site 653045021832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045021833 Protein of unknown function (DUF2690); Region: DUF2690; pfam10901 653045021834 Protein of unknown function (DUF3017); Region: DUF3017; pfam11222 653045021835 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 653045021836 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 653045021837 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 653045021838 homodimer interface [polypeptide binding]; other site 653045021839 NADP binding site [chemical binding]; other site 653045021840 substrate binding site [chemical binding]; other site 653045021841 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 653045021842 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 653045021843 purine monophosphate binding site [chemical binding]; other site 653045021844 dimer interface [polypeptide binding]; other site 653045021845 putative catalytic residues [active] 653045021846 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 653045021847 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 653045021848 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 653045021849 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 653045021850 active site 653045021851 substrate binding site [chemical binding]; other site 653045021852 cosubstrate binding site; other site 653045021853 catalytic site [active] 653045021854 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 653045021855 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021856 CoA-ligase; Region: Ligase_CoA; cl02894 653045021857 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 653045021858 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045021859 CoA-ligase; Region: Ligase_CoA; cl02894 653045021860 E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387 653045021861 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 653045021862 metal ion-dependent adhesion site (MIDAS); other site 653045021863 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021864 SWIM zinc finger; Region: SWIM; cl15408 653045021865 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 653045021866 B12 binding site [chemical binding]; other site 653045021867 cobalt ligand [ion binding]; other site 653045021868 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 653045021869 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045021870 Peptidase family M23; Region: Peptidase_M23; pfam01551 653045021871 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 653045021872 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045021873 Family description; Region: UvrD_C_2; cl15862 653045021874 NlpC/P60 family; Region: NLPC_P60; cl11438 653045021875 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 653045021876 NlpC/P60 family; Region: NLPC_P60; cl11438 653045021877 short chain dehydrogenase; Provisional; Region: PRK06197 653045021878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045021879 NAD(P) binding site [chemical binding]; other site 653045021880 active site 653045021881 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045021882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045021883 active site 653045021884 phosphorylation site [posttranslational modification] 653045021885 intermolecular recognition site; other site 653045021886 dimerization interface [polypeptide binding]; other site 653045021887 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045021888 DNA binding residues [nucleotide binding] 653045021889 dimerization interface [polypeptide binding]; other site 653045021890 PspC domain; Region: PspC; cl00864 653045021891 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045021892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045021893 ATP binding site [chemical binding]; other site 653045021894 Mg2+ binding site [ion binding]; other site 653045021895 G-X-G motif; other site 653045021896 PspC domain; Region: PspC; cl00864 653045021897 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045021898 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045021899 active site 653045021900 ATP binding site [chemical binding]; other site 653045021901 substrate binding site [chemical binding]; other site 653045021902 activation loop (A-loop); other site 653045021903 DoxX; Region: DoxX; cl00976 653045021904 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 653045021905 intersubunit interface [polypeptide binding]; other site 653045021906 active site 653045021907 Zn2+ binding site [ion binding]; other site 653045021908 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045021909 putative active site [active] 653045021910 GMP synthase; Reviewed; Region: guaA; PRK00074 653045021911 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 653045021912 AMP/PPi binding site [chemical binding]; other site 653045021913 candidate oxyanion hole; other site 653045021914 catalytic triad [active] 653045021915 potential glutamine specificity residues [chemical binding]; other site 653045021916 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 653045021917 ATP Binding subdomain [chemical binding]; other site 653045021918 Ligand Binding sites [chemical binding]; other site 653045021919 Dimerization subdomain; other site 653045021920 Chorismate mutase type II; Region: CM_2; cl00693 653045021921 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 653045021922 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 653045021923 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 2-like; Region: ALDH_SSADH2_GabD2; cd07101 653045021924 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045021925 NAD(P) binding site [chemical binding]; other site 653045021926 catalytic residues [active] 653045021927 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045021928 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045021929 active site 653045021930 ATP binding site [chemical binding]; other site 653045021931 substrate binding site [chemical binding]; other site 653045021932 activation loop (A-loop); other site 653045021933 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 653045021934 Catalytic domain of Protein Kinases; Region: PKc; cd00180 653045021935 active site 653045021936 ATP binding site [chemical binding]; other site 653045021937 substrate binding site [chemical binding]; other site 653045021938 activation loop (A-loop); other site 653045021939 IgA Peptidase M64; Region: Peptidase_M64; pfam09471 653045021940 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045021941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045021942 non-specific DNA binding site [nucleotide binding]; other site 653045021943 salt bridge; other site 653045021944 sequence-specific DNA binding site [nucleotide binding]; other site 653045021945 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045021946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045021947 active site 653045021948 phosphorylation site [posttranslational modification] 653045021949 intermolecular recognition site; other site 653045021950 dimerization interface [polypeptide binding]; other site 653045021951 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045021952 DNA binding residues [nucleotide binding] 653045021953 dimerization interface [polypeptide binding]; other site 653045021954 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045021955 Histidine kinase; Region: HisKA_3; pfam07730 653045021956 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045021957 anti sigma factor interaction site; other site 653045021958 regulatory phosphorylation site [posttranslational modification]; other site 653045021959 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 653045021960 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045021961 Putative zinc-finger; Region: zf-HC2; cl15806 653045021962 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 653045021963 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 653045021964 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 653045021965 putative active site [active] 653045021966 putative substrate binding site [chemical binding]; other site 653045021967 putative cosubstrate binding site; other site 653045021968 catalytic site [active] 653045021969 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_7; cd06341 653045021970 putative ligand binding site [chemical binding]; other site 653045021971 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 653045021972 polymerase nucleotide-binding site; other site 653045021973 DNA-binding residues [nucleotide binding]; DNA binding site 653045021974 nucleotide binding site [chemical binding]; other site 653045021975 primase nucleotide-binding site [nucleotide binding]; other site 653045021976 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 653045021977 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 653045021978 Walker A/P-loop; other site 653045021979 ATP binding site [chemical binding]; other site 653045021980 Q-loop/lid; other site 653045021981 ABC transporter signature motif; other site 653045021982 Walker B; other site 653045021983 D-loop; other site 653045021984 H-loop/switch region; other site 653045021985 L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought...; Region: LMO_FMN; cd03332 653045021986 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 653045021987 putative active site [active] 653045021988 putative substrate binding site [chemical binding]; other site 653045021989 putative FMN binding site [chemical binding]; other site 653045021990 putative catalytic residues [active] 653045021991 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045021992 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045021993 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 653045021994 Helix-turn-helix domains; Region: HTH; cl00088 653045021995 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 653045021996 hypothetical protein; Provisional; Region: PRK02947 653045021997 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 653045021998 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 653045021999 putative active site [active] 653045022000 PAS domain; Region: PAS_9; pfam13426 653045022001 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045022002 putative active site [active] 653045022003 heme pocket [chemical binding]; other site 653045022004 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 653045022005 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045022006 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 653045022007 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 653045022008 dimer interface [polypeptide binding]; other site 653045022009 Citrate synthase; Region: Citrate_synt; pfam00285 653045022010 active site 653045022011 citrylCoA binding site [chemical binding]; other site 653045022012 oxalacetate/citrate binding site [chemical binding]; other site 653045022013 coenzyme A binding site [chemical binding]; other site 653045022014 catalytic triad [active] 653045022015 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 653045022016 Helix-turn-helix domains; Region: HTH; cl00088 653045022017 enoyl-CoA hydratase; Provisional; Region: PRK07827 653045022018 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 653045022019 substrate binding site [chemical binding]; other site 653045022020 oxyanion hole (OAH) forming residues; other site 653045022021 trimer interface [polypeptide binding]; other site 653045022022 4-coumarate--CoA ligase; Region: PLN02246 653045022023 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022024 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 653045022025 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 653045022026 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 653045022027 active site 653045022028 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 653045022029 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 653045022030 ATP-grasp domain; Region: ATP-grasp_4; cl03087 653045022031 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 653045022032 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 653045022033 carboxyltransferase (CT) interaction site; other site 653045022034 biotinylation site [posttranslational modification]; other site 653045022035 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 653045022036 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045022037 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 653045022038 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 653045022039 TIGR03084 family protein; Region: TIGR03084 653045022040 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045022041 Wyosine base formation; Region: Wyosine_form; pfam08608 653045022042 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 653045022043 FAD binding domain; Region: FAD_binding_4; pfam01565 653045022044 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 653045022045 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 653045022046 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045022047 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045022048 catalytic residue [active] 653045022049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 653045022050 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045022051 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045022052 active site 653045022053 catalytic tetrad [active] 653045022054 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 653045022055 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 653045022056 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045022057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045022058 putative substrate translocation pore; other site 653045022059 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 653045022060 Helix-turn-helix domains; Region: HTH; cl00088 653045022061 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 653045022062 S-adenosyl methyltransferase; Region: Methyltransf_19; pfam04672 653045022063 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 653045022064 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045022065 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 653045022066 NMT1-like family; Region: NMT1_2; cl15260 653045022067 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045022068 DNA-binding site [nucleotide binding]; DNA binding site 653045022069 RNA-binding motif; other site 653045022070 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 653045022071 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045022072 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045022073 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 653045022074 ABC-ATPase subunit interface; other site 653045022075 dimer interface [polypeptide binding]; other site 653045022076 putative PBP binding regions; other site 653045022077 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 653045022078 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 653045022079 ABC-ATPase subunit interface; other site 653045022080 dimer interface [polypeptide binding]; other site 653045022081 putative PBP binding regions; other site 653045022082 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 653045022083 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 653045022084 Walker A/P-loop; other site 653045022085 ATP binding site [chemical binding]; other site 653045022086 Q-loop/lid; other site 653045022087 ABC transporter signature motif; other site 653045022088 Walker B; other site 653045022089 D-loop; other site 653045022090 H-loop/switch region; other site 653045022091 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 653045022092 WYL domain; Region: WYL; cl14852 653045022093 VanZ like family; Region: VanZ; cl01971 653045022094 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 653045022095 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 653045022096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 653045022097 ATP binding site [chemical binding]; other site 653045022098 putative Mg++ binding site [ion binding]; other site 653045022099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045022100 nucleotide binding region [chemical binding]; other site 653045022101 ATP-binding site [chemical binding]; other site 653045022102 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 653045022103 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022104 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 653045022105 Family description; Region: UvrD_C_2; cl15862 653045022106 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045022107 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 653045022108 active site 653045022109 metal binding site [ion binding]; metal-binding site 653045022110 CutC family; Region: CutC; cl01218 653045022111 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 653045022112 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 653045022113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045022114 putative substrate translocation pore; other site 653045022115 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 653045022116 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 653045022117 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 653045022118 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 653045022119 putative active site [active] 653045022120 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 653045022121 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 653045022122 putative active site [active] 653045022123 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 653045022124 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 653045022125 ring oligomerisation interface [polypeptide binding]; other site 653045022126 ATP/Mg binding site [chemical binding]; other site 653045022127 stacking interactions; other site 653045022128 hinge regions; other site 653045022129 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045022130 DNA-binding site [nucleotide binding]; DNA binding site 653045022131 RNA-binding motif; other site 653045022132 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 653045022133 MoaE interaction surface [polypeptide binding]; other site 653045022134 MoeB interaction surface [polypeptide binding]; other site 653045022135 thiocarboxylated glycine; other site 653045022136 threonine synthase; Validated; Region: PRK07591 653045022137 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 653045022138 homodimer interface [polypeptide binding]; other site 653045022139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045022140 catalytic residue [active] 653045022141 putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915 653045022142 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045022143 active site 653045022144 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 653045022145 active site 653045022146 homotetramer interface [polypeptide binding]; other site 653045022147 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045022148 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 653045022149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 653045022150 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 653045022151 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 653045022152 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 653045022153 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 653045022154 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 653045022155 active site 653045022156 dimer interface [polypeptide binding]; other site 653045022157 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 653045022158 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 653045022159 putative substrate binding site [chemical binding]; other site 653045022160 putative ATP binding site [chemical binding]; other site 653045022161 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 653045022162 putative metal binding site [ion binding]; other site 653045022163 PAS domain S-box; Region: sensory_box; TIGR00229 653045022164 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045022165 putative active site [active] 653045022166 heme pocket [chemical binding]; other site 653045022167 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 653045022168 metal binding site [ion binding]; metal-binding site 653045022169 active site 653045022170 I-site; other site 653045022171 Flavin Reductases; Region: FlaRed; cl00801 653045022172 RF-1 domain; Region: RF-1; cl02875 653045022173 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045022174 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045022175 putative metal binding site [ion binding]; other site 653045022176 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 653045022177 putative active site [active] 653045022178 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 653045022179 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 653045022180 putative NAD(P) binding site [chemical binding]; other site 653045022181 putative substrate binding site [chemical binding]; other site 653045022182 catalytic Zn binding site [ion binding]; other site 653045022183 structural Zn binding site [ion binding]; other site 653045022184 dimer interface [polypeptide binding]; other site 653045022185 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 653045022186 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 653045022187 active site 653045022188 Zn binding site [ion binding]; other site 653045022189 mycothiol-dependent formaldehyde dehydrogenase; Region: mycoS_dep_FDH; TIGR03451 653045022190 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 653045022191 NAD binding site [chemical binding]; other site 653045022192 catalytic Zn binding site [ion binding]; other site 653045022193 substrate binding site [chemical binding]; other site 653045022194 structural Zn binding site [ion binding]; other site 653045022195 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045022196 Flavin Reductases; Region: FlaRed; cl00801 653045022197 peptide synthase; Provisional; Region: PRK12467 653045022198 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022199 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022200 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022201 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045022202 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022203 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022204 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022205 peptide synthase; Provisional; Region: PRK12467 653045022206 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045022207 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022208 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022209 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022210 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045022211 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022212 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022213 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022214 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022215 Condensation domain; Region: Condensation; pfam00668 653045022216 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045022217 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045022218 peptide synthase; Provisional; Region: PRK12467 653045022219 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022220 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022221 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045022222 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022223 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022224 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045022225 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022226 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022227 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022228 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 653045022229 peptide synthase; Provisional; Region: PRK12467 653045022230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045022231 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022232 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022233 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022234 peptide synthase; Provisional; Region: PRK12467 653045022235 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045022236 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022237 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022238 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022239 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 653045022240 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022241 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022242 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 653045022243 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045022244 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045022245 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 653045022246 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045022247 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022248 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045022249 Walker A/P-loop; other site 653045022250 ATP binding site [chemical binding]; other site 653045022251 Q-loop/lid; other site 653045022252 ABC transporter signature motif; other site 653045022253 Walker B; other site 653045022254 D-loop; other site 653045022255 H-loop/switch region; other site 653045022256 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045022257 4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263 653045022258 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 653045022259 dimer interface [polypeptide binding]; other site 653045022260 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 653045022261 active site 653045022262 Fe binding site [ion binding]; other site 653045022263 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 653045022264 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 653045022265 active site 653045022266 substrate binding site [chemical binding]; other site 653045022267 FMN binding site [chemical binding]; other site 653045022268 putative catalytic residues [active] 653045022269 aspartate aminotransferase; Provisional; Region: PRK05764 653045022270 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045022271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045022272 homodimer interface [polypeptide binding]; other site 653045022273 catalytic residue [active] 653045022274 prephenate dehydrogenase; Validated; Region: PRK06545 653045022275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045022276 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 653045022277 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045022278 MbtH-like protein; Region: MbtH; cl01279 653045022279 2-hydroxychromene-2-carboxylate isomerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NahD; COG3917 653045022280 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 653045022281 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 653045022282 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 653045022283 NAD(P) binding site [chemical binding]; other site 653045022284 homotetramer interface [polypeptide binding]; other site 653045022285 homodimer interface [polypeptide binding]; other site 653045022286 active site 653045022287 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 653045022288 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045022289 active site 2 [active] 653045022290 active site 1 [active] 653045022291 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045022292 active site 653045022293 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045022294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045022295 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 653045022296 active site 653045022297 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 653045022298 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 653045022299 dimer interface [polypeptide binding]; other site 653045022300 active site 653045022301 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 653045022302 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 653045022303 dimer interface [polypeptide binding]; other site 653045022304 active site 653045022305 Phosphopantetheine attachment site; Region: PP-binding; cl09936 653045022306 Helix-turn-helix domains; Region: HTH; cl00088 653045022307 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 653045022308 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045022309 Helix-turn-helix domains; Region: HTH; cl00088 653045022310 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045022311 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 653045022312 Helix-turn-helix domains; Region: HTH; cl00088 653045022313 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 653045022314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045022315 DNA binding residues [nucleotide binding] 653045022316 dimerization interface [polypeptide binding]; other site 653045022317 Helix-turn-helix domains; Region: HTH; cl00088 653045022318 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 653045022319 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 653045022320 Walker A/P-loop; other site 653045022321 ATP binding site [chemical binding]; other site 653045022322 Q-loop/lid; other site 653045022323 ABC transporter signature motif; other site 653045022324 Walker B; other site 653045022325 D-loop; other site 653045022326 H-loop/switch region; other site 653045022327 TOBE domain; Region: TOBE_2; cl01440 653045022328 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 653045022329 active site 653045022330 Substrate binding site; other site 653045022331 Mg++ binding site; other site 653045022332 DoxX; Region: DoxX; cl00976 653045022333 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 653045022334 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 653045022335 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 653045022336 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 653045022337 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 653045022338 active site 653045022339 HIGH motif; other site 653045022340 nucleotide binding site [chemical binding]; other site 653045022341 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 653045022342 KMSKS motif; other site 653045022343 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 653045022344 tRNA binding surface [nucleotide binding]; other site 653045022345 anticodon binding site; other site 653045022346 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 653045022347 homotrimer interaction site [polypeptide binding]; other site 653045022348 zinc binding site [ion binding]; other site 653045022349 CDP-binding sites; other site 653045022350 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 653045022351 substrate binding site; other site 653045022352 dimer interface; other site 653045022353 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 653045022354 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045022355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022356 active site 653045022357 phosphorylation site [posttranslational modification] 653045022358 intermolecular recognition site; other site 653045022359 dimerization interface [polypeptide binding]; other site 653045022360 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045022361 DNA binding site [nucleotide binding] 653045022362 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 653045022363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045022364 dimer interface [polypeptide binding]; other site 653045022365 phosphorylation site [posttranslational modification] 653045022366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045022367 ATP binding site [chemical binding]; other site 653045022368 Mg2+ binding site [ion binding]; other site 653045022369 G-X-G motif; other site 653045022370 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 653045022371 PhoU domain; Region: PhoU; pfam01895 653045022372 PhoU domain; Region: PhoU; pfam01895 653045022373 FOG: WD40 repeat [General function prediction only]; Region: COG2319 653045022374 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045022375 structural tetrad; other site 653045022376 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 653045022377 structural tetrad; other site 653045022378 FOG: WD40 repeat [General function prediction only]; Region: COG2319 653045022379 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045022380 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045022381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 653045022382 active site 653045022383 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045022384 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045022385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045022386 DNA-binding site [nucleotide binding]; DNA binding site 653045022387 UTRA domain; Region: UTRA; cl01230 653045022388 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045022389 putative DNA binding site [nucleotide binding]; other site 653045022390 dimerization interface [polypeptide binding]; other site 653045022391 putative Zn2+ binding site [ion binding]; other site 653045022392 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045022393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045022394 UTRA domain; Region: UTRA; cl01230 653045022395 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045022396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045022397 DNA-binding site [nucleotide binding]; DNA binding site 653045022398 UTRA domain; Region: UTRA; cl01230 653045022399 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 653045022400 classical (c) SDRs; Region: SDR_c; cd05233 653045022401 NAD(P) binding site [chemical binding]; other site 653045022402 active site 653045022403 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045022404 putative DNA binding site [nucleotide binding]; other site 653045022405 putative Zn2+ binding site [ion binding]; other site 653045022406 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 653045022407 catalytic core [active] 653045022408 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 653045022409 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045022410 Major Facilitator Superfamily; Region: MFS_1; pfam07690 653045022411 putative substrate translocation pore; other site 653045022412 Peptidase family M48; Region: Peptidase_M48; cl12018 653045022413 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 653045022414 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045022415 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045022416 DNA binding residues [nucleotide binding] 653045022417 NIMA-related protein kinase; Provisional; Region: PTZ00266 653045022418 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 653045022419 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 653045022420 UDP-N-acetylglucosamine: 1L-myo-inositol-1-phosphate 1-alpha-D-N-acetylglucosaminyltransferase; Region: mycothiol_MshA; TIGR03449 653045022421 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 653045022422 putative ADP-binding pocket [chemical binding]; other site 653045022423 Spore germination protein; Region: Spore_permease; cl15802 653045022424 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045022425 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 653045022426 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 653045022427 active site 653045022428 catalytic tetrad [active] 653045022429 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 653045022430 active site 653045022431 Ap6A binding site [chemical binding]; other site 653045022432 nudix motif; other site 653045022433 metal binding site [ion binding]; metal-binding site 653045022434 polyphosphate kinase; Provisional; Region: PRK05443 653045022435 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 653045022436 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 653045022437 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 653045022438 putative domain interface [polypeptide binding]; other site 653045022439 putative active site [active] 653045022440 catalytic site [active] 653045022441 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 653045022442 putative domain interface [polypeptide binding]; other site 653045022443 putative active site [active] 653045022444 catalytic site [active] 653045022445 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 653045022446 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045022447 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045022448 Coenzyme A binding pocket [chemical binding]; other site 653045022449 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 653045022450 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 653045022451 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 653045022452 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 653045022453 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 653045022454 putative active site [active] 653045022455 putative metal binding site [ion binding]; other site 653045022456 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 653045022457 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 653045022458 glycosyltransferase, MGT family; Region: MGT; TIGR01426 653045022459 active site 653045022460 TDP-binding site; other site 653045022461 acceptor substrate-binding pocket; other site 653045022462 homodimer interface [polypeptide binding]; other site 653045022463 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045022464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045022465 non-specific DNA binding site [nucleotide binding]; other site 653045022466 salt bridge; other site 653045022467 sequence-specific DNA binding site [nucleotide binding]; other site 653045022468 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 653045022469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045022470 ATP binding site [chemical binding]; other site 653045022471 Mg2+ binding site [ion binding]; other site 653045022472 G-X-G motif; other site 653045022473 Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635 653045022474 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022475 Clp protease ATP binding subunit; Region: clpC; CHL00095 653045022476 Clp amino terminal domain; Region: Clp_N; pfam02861 653045022477 Clp amino terminal domain; Region: Clp_N; pfam02861 653045022478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045022479 Walker A motif; other site 653045022480 ATP binding site [chemical binding]; other site 653045022481 Walker B motif; other site 653045022482 arginine finger; other site 653045022483 UvrB/uvrC motif; Region: UVR; pfam02151 653045022484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045022485 Walker A motif; other site 653045022486 ATP binding site [chemical binding]; other site 653045022487 Walker B motif; other site 653045022488 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 653045022489 Lsr2; Region: Lsr2; pfam11774 653045022490 amino-acid N-acetyltransferase; Region: N-Ac-Glu-synth; TIGR01890 653045022491 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045022492 Coenzyme A binding pocket [chemical binding]; other site 653045022493 Helix-turn-helix domains; Region: HTH; cl00088 653045022494 Type III pantothenate kinase; Region: Pan_kinase; cl09130 653045022495 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07896 653045022496 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 653045022497 dimerization interface [polypeptide binding]; other site 653045022498 active site 653045022499 L-aspartate oxidase; Provisional; Region: PRK07804 653045022500 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045022501 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 653045022502 pantoate--beta-alanine ligase; Region: panC; TIGR00018 653045022503 Pantoate-beta-alanine ligase; Region: PanC; cd00560 653045022504 active site 653045022505 ATP-binding site [chemical binding]; other site 653045022506 pantoate-binding site; other site 653045022507 HXXH motif; other site 653045022508 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045022509 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 653045022510 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 653045022511 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 653045022512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 653045022513 catalytic residue [active] 653045022514 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 653045022515 dimerization interface [polypeptide binding]; other site 653045022516 putative DNA binding site [nucleotide binding]; other site 653045022517 putative Zn2+ binding site [ion binding]; other site 653045022518 Helix-turn-helix domains; Region: HTH; cl00088 653045022519 Helix-turn-helix domains; Region: HTH; cl00088 653045022520 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045022521 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022522 active site 653045022523 phosphorylation site [posttranslational modification] 653045022524 intermolecular recognition site; other site 653045022525 dimerization interface [polypeptide binding]; other site 653045022526 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045022527 DNA binding residues [nucleotide binding] 653045022528 dimerization interface [polypeptide binding]; other site 653045022529 Histidine kinase; Region: HisKA_3; pfam07730 653045022530 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045022531 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 653045022532 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 653045022533 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 653045022534 NMT1-like family; Region: NMT1_2; cl15260 653045022535 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 653045022536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045022537 dimer interface [polypeptide binding]; other site 653045022538 conserved gate region; other site 653045022539 ABC-ATPase subunit interface; other site 653045022540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 653045022541 dimer interface [polypeptide binding]; other site 653045022542 conserved gate region; other site 653045022543 ABC-ATPase subunit interface; other site 653045022544 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 653045022545 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 653045022546 Walker A/P-loop; other site 653045022547 ATP binding site [chemical binding]; other site 653045022548 Q-loop/lid; other site 653045022549 ABC transporter signature motif; other site 653045022550 Walker B; other site 653045022551 D-loop; other site 653045022552 H-loop/switch region; other site 653045022553 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 653045022554 Predicted esterase [General function prediction only]; Region: COG0627 653045022555 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045022556 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 653045022557 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 653045022558 substrate binding pocket [chemical binding]; other site 653045022559 inhibitor binding site; inhibition site 653045022560 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045022561 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 653045022562 homooctamer interface [polypeptide binding]; other site 653045022563 active site 653045022564 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 653045022565 catalytic center binding site [active] 653045022566 ATP binding site [chemical binding]; other site 653045022567 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 653045022568 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 653045022569 homodecamer interface [polypeptide binding]; other site 653045022570 GTP cyclohydrolase I; Provisional; Region: PLN03044 653045022571 active site 653045022572 putative catalytic site residues [active] 653045022573 zinc binding site [ion binding]; other site 653045022574 GTP-CH-I/GFRP interaction surface; other site 653045022575 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 653045022576 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045022577 Walker A motif; other site 653045022578 ATP binding site [chemical binding]; other site 653045022579 Walker B motif; other site 653045022580 arginine finger; other site 653045022581 Peptidase family M41; Region: Peptidase_M41; pfam01434 653045022582 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 653045022583 active site 653045022584 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 653045022585 Ligand Binding Site [chemical binding]; other site 653045022586 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 653045022587 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045022588 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 653045022589 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045022590 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 653045022591 dimer interface [polypeptide binding]; other site 653045022592 substrate binding site [chemical binding]; other site 653045022593 metal binding sites [ion binding]; metal-binding site 653045022594 Uncharacterized conserved protein [Function unknown]; Region: COG2966 653045022595 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 653045022596 Protein of unknown function (DUF1212); Region: DUF1212; cl01118 653045022597 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 653045022598 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 653045022599 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045022600 DNA binding residues [nucleotide binding] 653045022601 dimer interface [polypeptide binding]; other site 653045022602 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 653045022603 LysE type translocator; Region: LysE; cl00565 653045022604 LysE type translocator; Region: LysE; cl00565 653045022605 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 653045022606 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 653045022607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045022608 catalytic residue [active] 653045022609 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045022610 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022611 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045022612 Walker A/P-loop; other site 653045022613 ATP binding site [chemical binding]; other site 653045022614 Q-loop/lid; other site 653045022615 ABC transporter signature motif; other site 653045022616 Walker B; other site 653045022617 D-loop; other site 653045022618 H-loop/switch region; other site 653045022619 Helix-turn-helix domains; Region: HTH; cl00088 653045022620 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 653045022621 DinB superfamily; Region: DinB_2; pfam12867 653045022622 NADP+-dependent p-hydroxybenzaldehyde dehydrogenase-like; Region: ALDH_HBenzADH; cd07151 653045022623 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 653045022624 NAD(P) binding site [chemical binding]; other site 653045022625 catalytic residues [active] 653045022626 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045022627 non-specific DNA binding site [nucleotide binding]; other site 653045022628 salt bridge; other site 653045022629 sequence-specific DNA binding site [nucleotide binding]; other site 653045022630 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045022631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045022632 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 653045022633 active site 653045022634 putative substrate binding region [chemical binding]; other site 653045022635 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 653045022636 Domain of unknown function (DUF397); Region: DUF397; pfam04149 653045022637 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 653045022638 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 653045022639 active site 653045022640 DNA binding site [nucleotide binding] 653045022641 catalytic site [active] 653045022642 rod shape-determining protein MreB; Provisional; Region: PRK13930 653045022643 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 653045022644 ATP binding site [chemical binding]; other site 653045022645 profilin binding site; other site 653045022646 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 653045022647 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045022648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045022649 DNA binding residues [nucleotide binding] 653045022650 Putative zinc-finger; Region: zf-HC2; cl15806 653045022651 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 653045022652 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045022653 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045022654 DNA binding residues [nucleotide binding] 653045022655 Putative zinc-finger; Region: zf-HC2; cl15806 653045022656 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 653045022657 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 653045022658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022659 active site 653045022660 phosphorylation site [posttranslational modification] 653045022661 intermolecular recognition site; other site 653045022662 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 653045022663 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 653045022664 active site 653045022665 catalytic residues [active] 653045022666 GtrA-like protein; Region: GtrA; cl00971 653045022667 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 653045022668 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 653045022669 active site 653045022670 N-glycosyltransferase; Provisional; Region: PRK11204 653045022671 Brain acid soluble protein 1 (BASP1 protein); Region: BASP1; pfam05466 653045022672 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 653045022673 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045022674 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 653045022675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022676 active site 653045022677 phosphorylation site [posttranslational modification] 653045022678 intermolecular recognition site; other site 653045022679 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 653045022680 PAS domain; Region: PAS_9; pfam13426 653045022681 PAS domain S-box; Region: sensory_box; TIGR00229 653045022682 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045022683 putative active site [active] 653045022684 heme pocket [chemical binding]; other site 653045022685 Histidine kinase; Region: HisKA_3; pfam07730 653045022686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045022687 ATP binding site [chemical binding]; other site 653045022688 Mg2+ binding site [ion binding]; other site 653045022689 G-X-G motif; other site 653045022690 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045022691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022692 active site 653045022693 phosphorylation site [posttranslational modification] 653045022694 intermolecular recognition site; other site 653045022695 dimerization interface [polypeptide binding]; other site 653045022696 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045022697 DNA binding residues [nucleotide binding] 653045022698 dimerization interface [polypeptide binding]; other site 653045022699 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 653045022700 active site 653045022701 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045022702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022703 active site 653045022704 phosphorylation site [posttranslational modification] 653045022705 intermolecular recognition site; other site 653045022706 dimerization interface [polypeptide binding]; other site 653045022707 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045022708 DNA binding residues [nucleotide binding] 653045022709 dimerization interface [polypeptide binding]; other site 653045022710 GAF domain; Region: GAF_2; pfam13185 653045022711 GAF domain; Region: GAF; cl15785 653045022712 GAF domain; Region: GAF; cl15785 653045022713 Histidine kinase; Region: HisKA_3; pfam07730 653045022714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045022715 ATP binding site [chemical binding]; other site 653045022716 Mg2+ binding site [ion binding]; other site 653045022717 G-X-G motif; other site 653045022718 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 653045022719 substrate binding pocket [chemical binding]; other site 653045022720 substrate-Mg2+ binding site; other site 653045022721 aspartate-rich region 1; other site 653045022722 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 653045022723 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 653045022724 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045022725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045022726 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045022727 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045022728 DNA binding residues [nucleotide binding] 653045022729 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 653045022730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045022731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022732 active site 653045022733 phosphorylation site [posttranslational modification] 653045022734 intermolecular recognition site; other site 653045022735 dimerization interface [polypeptide binding]; other site 653045022736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045022737 DNA binding residues [nucleotide binding] 653045022738 dimerization interface [polypeptide binding]; other site 653045022739 Histidine kinase; Region: HisKA_3; pfam07730 653045022740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045022741 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045022742 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 653045022743 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 653045022744 FOG: CBS domain [General function prediction only]; Region: COG0517 653045022745 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 653045022746 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 653045022747 DEAD-like helicases superfamily; Region: DEXDc; smart00487 653045022748 ATP binding site [chemical binding]; other site 653045022749 Mg++ binding site [ion binding]; other site 653045022750 motif III; other site 653045022751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045022752 nucleotide binding region [chemical binding]; other site 653045022753 ATP-binding site [chemical binding]; other site 653045022754 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 653045022755 DNA-binding site [nucleotide binding]; DNA binding site 653045022756 RNA-binding motif; other site 653045022757 Haemolysin-III related; Region: HlyIII; cl03831 653045022758 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 653045022759 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 653045022760 DNA binding residues [nucleotide binding] 653045022761 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045022762 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 653045022763 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045022764 DNA polymerase III subunit delta'; Validated; Region: PRK07940 653045022765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022766 thymidylate kinase; Validated; Region: tmk; PRK00698 653045022767 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 653045022768 TMP-binding site; other site 653045022769 ATP-binding site [chemical binding]; other site 653045022770 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 653045022771 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 653045022772 active site 653045022773 interdomain interaction site; other site 653045022774 putative metal-binding site [ion binding]; other site 653045022775 nucleotide binding site [chemical binding]; other site 653045022776 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 653045022777 domain I; other site 653045022778 phosphate binding site [ion binding]; other site 653045022779 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 653045022780 domain II; other site 653045022781 domain III; other site 653045022782 nucleotide binding site [chemical binding]; other site 653045022783 DNA binding groove [nucleotide binding] 653045022784 catalytic site [active] 653045022785 domain IV; other site 653045022786 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 653045022787 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 653045022788 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 653045022789 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045022790 S-adenosylmethionine binding site [chemical binding]; other site 653045022791 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 653045022792 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 653045022793 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045022794 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045022795 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 653045022796 anti sigma factor interaction site; other site 653045022797 regulatory phosphorylation site [posttranslational modification]; other site 653045022798 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 653045022799 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022800 ATP binding site [chemical binding]; other site 653045022801 putative Mg++ binding site [ion binding]; other site 653045022802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 653045022803 nucleotide binding region [chemical binding]; other site 653045022804 ATP-binding site [chemical binding]; other site 653045022805 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 653045022806 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 653045022807 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 653045022808 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 653045022809 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 653045022810 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 653045022811 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 653045022812 ATP binding site [chemical binding]; other site 653045022813 Walker A motif; other site 653045022814 hexamer interface [polypeptide binding]; other site 653045022815 Walker B motif; other site 653045022816 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 653045022817 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 653045022818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045022819 motif II; other site 653045022820 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 653045022821 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 653045022822 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 653045022823 active site clefts [active] 653045022824 zinc binding site [ion binding]; other site 653045022825 dimer interface [polypeptide binding]; other site 653045022826 acetyl-CoA synthetase; Provisional; Region: PRK00174 653045022827 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 653045022828 AMP-binding enzyme; Region: AMP-binding; cl15778 653045022829 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045022830 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 653045022831 Protein of unknown function (DUF1469); Region: DUF1469; cl12095 653045022832 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 653045022833 Colicin V production protein; Region: Colicin_V; cl00567 653045022834 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045022835 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 653045022836 putative active site [active] 653045022837 putative CoA binding site [chemical binding]; other site 653045022838 nudix motif; other site 653045022839 metal binding site [ion binding]; metal-binding site 653045022840 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 653045022841 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 653045022842 minor groove reading motif; other site 653045022843 helix-hairpin-helix signature motif; other site 653045022844 substrate binding pocket [chemical binding]; other site 653045022845 active site 653045022846 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 653045022847 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 653045022848 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 653045022849 ligand binding site [chemical binding]; other site 653045022850 flexible hinge region; other site 653045022851 Helix-turn-helix domains; Region: HTH; cl00088 653045022852 putative switch regulator; other site 653045022853 non-specific DNA interactions [nucleotide binding]; other site 653045022854 DNA binding site [nucleotide binding] 653045022855 sequence specific DNA binding site [nucleotide binding]; other site 653045022856 putative cAMP binding site [chemical binding]; other site 653045022857 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 653045022858 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 653045022859 homotrimer interaction site [polypeptide binding]; other site 653045022860 putative active site [active] 653045022861 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 653045022862 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 653045022863 DTAP/Switch II; other site 653045022864 Switch I; other site 653045022865 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 653045022866 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 653045022867 P loop; other site 653045022868 Nucleotide binding site [chemical binding]; other site 653045022869 DTAP/Switch II; other site 653045022870 Switch I; other site 653045022871 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 653045022872 Transcription factor WhiB; Region: Whib; pfam02467 653045022873 Transglycosylase; Region: Transgly; cl07896 653045022874 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 653045022875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045022876 GatB domain; Region: GatB_Yqey; cl11497 653045022877 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 653045022878 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 653045022879 putative active site [active] 653045022880 putative metal binding site [ion binding]; other site 653045022881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045022882 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045022883 DNA binding site [nucleotide binding] 653045022884 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 653045022885 DNA binding site [nucleotide binding] 653045022886 active site 653045022887 Int/Topo IB signature motif; other site 653045022888 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 653045022889 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 653045022890 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022891 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 653045022892 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 653045022893 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 653045022894 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 653045022895 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045022896 DNA-binding site [nucleotide binding]; DNA binding site 653045022897 UTRA domain; Region: UTRA; cl01230 653045022898 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045022899 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 653045022900 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 653045022901 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045022902 TOBE domain; Region: TOBE_2; cl01440 653045022903 TOBE domain; Region: TOBE_2; cl01440 653045022904 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045022905 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045022906 putative metal binding site [ion binding]; other site 653045022907 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 653045022908 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 653045022909 putative metal binding site [ion binding]; other site 653045022910 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 653045022911 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 653045022912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045022913 active site 653045022914 metal binding site [ion binding]; metal-binding site 653045022915 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045022916 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 653045022917 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 653045022918 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045022919 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 653045022920 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 653045022921 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 653045022922 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 653045022923 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045022924 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045022925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 653045022926 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 653045022927 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045022928 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 653045022929 aspartate kinase; Reviewed; Region: PRK06635 653045022930 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 653045022931 putative nucleotide binding site [chemical binding]; other site 653045022932 putative catalytic residues [active] 653045022933 putative Mg ion binding site [ion binding]; other site 653045022934 putative aspartate binding site [chemical binding]; other site 653045022935 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 653045022936 putative allosteric regulatory site; other site 653045022937 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 653045022938 putative allosteric regulatory residue; other site 653045022939 recombination protein RecR; Reviewed; Region: recR; PRK00076 653045022940 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 653045022941 RecR protein; Region: RecR; pfam02132 653045022942 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 653045022943 putative active site [active] 653045022944 putative metal-binding site [ion binding]; other site 653045022945 tetramer interface [polypeptide binding]; other site 653045022946 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 653045022947 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 653045022948 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 653045022949 Walker A motif; other site 653045022950 ATP binding site [chemical binding]; other site 653045022951 Walker B motif; other site 653045022952 arginine finger; other site 653045022953 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 653045022954 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 653045022955 Histidine kinase; Region: HisKA_3; pfam07730 653045022956 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045022957 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045022958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022959 active site 653045022960 phosphorylation site [posttranslational modification] 653045022961 intermolecular recognition site; other site 653045022962 dimerization interface [polypeptide binding]; other site 653045022963 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045022964 DNA binding residues [nucleotide binding] 653045022965 dimerization interface [polypeptide binding]; other site 653045022966 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190 653045022967 cleavage site 653045022968 active site 653045022969 substrate binding sites [chemical binding]; other site 653045022970 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045022971 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 653045022972 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 653045022973 Helix-turn-helix domains; Region: HTH; cl00088 653045022974 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 653045022975 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 653045022976 putative NAD(P) binding site [chemical binding]; other site 653045022977 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 653045022978 Putative sensor; Region: Sensor; pfam13796 653045022979 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 653045022980 Histidine kinase; Region: HisKA_3; pfam07730 653045022981 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 653045022982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045022983 active site 653045022984 phosphorylation site [posttranslational modification] 653045022985 intermolecular recognition site; other site 653045022986 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 653045022987 DNA binding residues [nucleotide binding] 653045022988 dimerization interface [polypeptide binding]; other site 653045022989 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 653045022990 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 653045022991 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 653045022992 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 653045022993 Walker A/P-loop; other site 653045022994 ATP binding site [chemical binding]; other site 653045022995 Q-loop/lid; other site 653045022996 ABC transporter signature motif; other site 653045022997 Walker B; other site 653045022998 D-loop; other site 653045022999 H-loop/switch region; other site 653045023000 glutamate dehydrogenase; Provisional; Region: PRK09414 653045023001 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 653045023002 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 653045023003 NAD(P) binding site [chemical binding]; other site 653045023004 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 653045023005 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045023006 Transcriptional regulator [Transcription]; Region: IclR; COG1414 653045023007 Helix-turn-helix domains; Region: HTH; cl00088 653045023008 Bacterial transcriptional regulator; Region: IclR; pfam01614 653045023009 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 653045023010 putative hydrophobic ligand binding site [chemical binding]; other site 653045023011 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 653045023012 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045023013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 653045023014 amidase; Provisional; Region: PRK07486 653045023015 Amidase; Region: Amidase; cl11426 653045023016 Non-plant Terpene Cyclases, Class 1; Region: Terpene_cyclase_nonplant_C1; cd00687 653045023017 substrate binding pocket [chemical binding]; other site 653045023018 substrate-Mg2+ binding site; other site 653045023019 aspartate-rich region 1; other site 653045023020 active site lid residues [active] 653045023021 aspartate-rich region 2; other site 653045023022 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 653045023023 substrate binding pocket [chemical binding]; other site 653045023024 substrate-Mg2+ binding site; other site 653045023025 aspartate-rich region 1; other site 653045023026 aspartate-rich region 2; other site 653045023027 OpgC protein; Region: OpgC_C; cl00792 653045023028 tellurite resistance protein terB; Region: terB; cd07176 653045023029 putative metal binding site [ion binding]; other site 653045023030 Peptidase family M48; Region: Peptidase_M48; cl12018 653045023031 Helix-turn-helix domains; Region: HTH; cl00088 653045023032 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078 653045023033 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 653045023034 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 653045023035 putative NAD(P) binding site [chemical binding]; other site 653045023036 putative active site [active] 653045023037 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 653045023038 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 653045023039 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 653045023040 active site 653045023041 putative tRNA adenosine deaminase-associated protein; Region: tRNA_deam_assoc; TIGR03941 653045023042 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 653045023043 nucleoside/Zn binding site; other site 653045023044 dimer interface [polypeptide binding]; other site 653045023045 catalytic motif [active] 653045023046 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 653045023047 Helix-turn-helix domains; Region: HTH; cl00088 653045023048 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 653045023049 FAD binding domain; Region: FAD_binding_4; pfam01565 653045023050 Berberine and berberine like; Region: BBE; pfam08031 653045023051 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 653045023052 active site 653045023053 ADP/pyrophosphate binding site [chemical binding]; other site 653045023054 dimerization interface [polypeptide binding]; other site 653045023055 allosteric effector site; other site 653045023056 fructose-1,6-bisphosphate binding site; other site 653045023057 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045023058 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045023059 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045023060 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045023061 DNA binding residues [nucleotide binding] 653045023062 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 653045023063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045023064 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 653045023065 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045023066 DNA binding residues [nucleotide binding] 653045023067 Helix-turn-helix domains; Region: HTH; cl00088 653045023068 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 653045023069 YceI-like domain; Region: YceI; cl01001 653045023070 Helix-turn-helix domains; Region: HTH; cl00088 653045023071 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 653045023072 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 653045023073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045023074 putative substrate translocation pore; other site 653045023075 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769 653045023076 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 653045023077 DPG_synthase is involved in protein N-linked glycosylation; Region: DPG_synthase; cd04188 653045023078 Ligand binding site; other site 653045023079 Ligand binding site; other site 653045023080 Ligand binding site; other site 653045023081 Putative Catalytic site; other site 653045023082 DXD motif; other site 653045023083 GtrA-like protein; Region: GtrA; cl00971 653045023084 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 653045023085 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 653045023086 dimer interface [polypeptide binding]; other site 653045023087 phosphorylation site [posttranslational modification] 653045023088 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045023089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 653045023090 ATP binding site [chemical binding]; other site 653045023091 G-X-G motif; other site 653045023092 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 653045023093 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045023094 active site 653045023095 phosphorylation site [posttranslational modification] 653045023096 intermolecular recognition site; other site 653045023097 dimerization interface [polypeptide binding]; other site 653045023098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 653045023099 DNA binding site [nucleotide binding] 653045023100 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045023101 F420-dependent oxidoreductase, MSMEG_4879 family; Region: F420_MSMEG_4879; TIGR03564 653045023102 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 653045023103 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 653045023104 active site 653045023105 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 653045023106 active site 653045023107 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 653045023108 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045023109 active site 653045023110 motif I; other site 653045023111 motif II; other site 653045023112 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 653045023113 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045023114 Family description; Region: VCBS; pfam13517 653045023115 Family description; Region: VCBS; pfam13517 653045023116 Family description; Region: VCBS; pfam13517 653045023117 FG-GAP repeat; Region: FG-GAP; cl15299 653045023118 DDE superfamily endonuclease; Region: DDE_4; cl15789 653045023119 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 653045023120 nudix motif; other site 653045023121 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 653045023122 catalytic motif [active] 653045023123 Zn binding site [ion binding]; other site 653045023124 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045023125 Subtilisin inhibitor-like; Region: SSI; cl11594 653045023126 PAS domain; Region: PAS_9; pfam13426 653045023127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 653045023128 PAS domain; Region: PAS_9; pfam13426 653045023129 putative active site [active] 653045023130 heme pocket [chemical binding]; other site 653045023131 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 653045023132 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 653045023133 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 653045023134 active site 653045023135 phosphorylation site [posttranslational modification] 653045023136 intermolecular recognition site; other site 653045023137 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 653045023138 AMP-binding enzyme; Region: AMP-binding; cl15778 653045023139 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 653045023140 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045023141 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045023142 DNA binding residues [nucleotide binding] 653045023143 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 653045023144 active site 653045023145 lipid-transfer protein; Provisional; Region: PRK07855 653045023146 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 653045023147 active site 653045023148 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045023149 active site 2 [active] 653045023150 active site 1 [active] 653045023151 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 653045023152 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 653045023153 DUF35 OB-fold domain; Region: DUF35; pfam01796 653045023154 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 653045023155 nucleotide binding site [chemical binding]; other site 653045023156 polymerase nucleotide-binding site; other site 653045023157 primase nucleotide-binding site [nucleotide binding]; other site 653045023158 DNA-binding residues [nucleotide binding]; DNA binding site 653045023159 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 653045023160 salt bridge; other site 653045023161 non-specific DNA binding site [nucleotide binding]; other site 653045023162 sequence-specific DNA binding site [nucleotide binding]; other site 653045023163 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 653045023164 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 653045023165 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 653045023166 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_like_2; cd08582 653045023167 putative active site [active] 653045023168 catalytic site [active] 653045023169 putative metal binding site [ion binding]; other site 653045023170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045023171 preprotein translocase subunit SecA; Reviewed; Region: PRK13107 653045023172 SEC-C motif; Region: SEC-C; pfam02810 653045023173 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 653045023174 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 653045023175 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 653045023176 proline aminopeptidase P II; Provisional; Region: PRK10879 653045023177 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 653045023178 active site 653045023179 Uncharacterized conserved protein [Function unknown]; Region: COG2128 653045023180 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 653045023181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045023182 DNA-binding site [nucleotide binding]; DNA binding site 653045023183 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 653045023184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045023185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045023186 homodimer interface [polypeptide binding]; other site 653045023187 catalytic residue [active] 653045023188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045023189 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 653045023190 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 653045023191 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 653045023192 Cu(I) binding site [ion binding]; other site 653045023193 Protein of unknown function (DUF461); Region: DUF461; cl01071 653045023194 Bacterial Ig-like domain; Region: Big_5; cl01012 653045023195 Copper resistance protein D; Region: CopD; cl00563 653045023196 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 653045023197 prephenate dehydratase; Provisional; Region: PRK11898 653045023198 Prephenate dehydratase; Region: PDT; pfam00800 653045023199 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 653045023200 putative L-Phe binding site [chemical binding]; other site 653045023201 seryl-tRNA synthetase; Provisional; Region: PRK05431 653045023202 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 653045023203 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 653045023204 dimer interface [polypeptide binding]; other site 653045023205 active site 653045023206 motif 1; other site 653045023207 motif 2; other site 653045023208 motif 3; other site 653045023209 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 653045023210 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045023211 Prokaryotic phospholipase A2; Region: Phospholip_A2_3; pfam09056 653045023212 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 653045023213 Helix-turn-helix domains; Region: HTH; cl00088 653045023214 Helix-turn-helix domains; Region: HTH; cl00088 653045023215 Helix-turn-helix domains; Region: HTH; cl00088 653045023216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045023217 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 653045023218 putative substrate translocation pore; other site 653045023219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 653045023220 DNA-binding site [nucleotide binding]; DNA binding site 653045023221 FCD domain; Region: FCD; cl11656 653045023222 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 653045023223 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 653045023224 putative substrate translocation pore; other site 653045023225 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045023226 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045023227 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 653045023228 Walker A/P-loop; other site 653045023229 ATP binding site [chemical binding]; other site 653045023230 Q-loop/lid; other site 653045023231 ABC transporter signature motif; other site 653045023232 Walker B; other site 653045023233 D-loop; other site 653045023234 H-loop/switch region; other site 653045023235 ABC-2 type transporter; Region: ABC2_membrane; cl11417 653045023236 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 653045023237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045023238 Walker A/P-loop; other site 653045023239 ATP binding site [chemical binding]; other site 653045023240 Q-loop/lid; other site 653045023241 ABC transporter signature motif; other site 653045023242 Walker B; other site 653045023243 D-loop; other site 653045023244 H-loop/switch region; other site 653045023245 Peptidase family M48; Region: Peptidase_M48; cl12018 653045023246 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 653045023247 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 653045023248 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 653045023249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 653045023250 active site 653045023251 motif I; other site 653045023252 motif II; other site 653045023253 GAF domain; Region: GAF; cl15785 653045023254 GAF domain; Region: GAF; cl15785 653045023255 Histidine kinase; Region: HisKA_3; pfam07730 653045023256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 653045023257 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 653045023258 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 653045023259 The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export. They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins. The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228 653045023260 Walker A/P-loop; other site 653045023261 ATP binding site [chemical binding]; other site 653045023262 Q-loop/lid; other site 653045023263 ABC transporter signature motif; other site 653045023264 Walker B; other site 653045023265 D-loop; other site 653045023266 H-loop/switch region; other site 653045023267 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 653045023268 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 653045023269 Walker A/P-loop; other site 653045023270 ATP binding site [chemical binding]; other site 653045023271 Q-loop/lid; other site 653045023272 ABC transporter signature motif; other site 653045023273 Walker B; other site 653045023274 D-loop; other site 653045023275 H-loop/switch region; other site 653045023276 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 653045023277 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 653045023278 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 653045023279 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 653045023280 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 653045023281 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 653045023282 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 653045023283 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045023284 homodimer interface [polypeptide binding]; other site 653045023285 catalytic residue [active] 653045023286 Transcriptional regulators [Transcription]; Region: PurR; COG1609 653045023287 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 653045023288 DNA binding site [nucleotide binding] 653045023289 domain linker motif; other site 653045023290 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 653045023291 ligand binding site [chemical binding]; other site 653045023292 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 653045023293 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 653045023294 active site 653045023295 metal binding site [ion binding]; metal-binding site 653045023296 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045023297 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 653045023298 ThiC-associated domain; Region: ThiC-associated; pfam13667 653045023299 ThiC family; Region: ThiC; cl08031 653045023300 YibE/F-like protein; Region: YibE_F; cl02259 653045023301 Streptomyces sporulation and cell division protein, SsgA; Region: SsgA; pfam04686 653045023302 Cupin domain; Region: Cupin_2; cl09118 653045023303 Membrane protein of unknown function; Region: DUF360; cl00850 653045023304 Low molecular weight phosphatase family; Region: LMWPc; cd00115 653045023305 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 653045023306 active site 653045023307 cystathionine gamma-lyase; Validated; Region: PRK07582 653045023308 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 653045023309 homodimer interface [polypeptide binding]; other site 653045023310 substrate-cofactor binding pocket; other site 653045023311 pyridoxal 5'-phosphate binding site [chemical binding]; other site 653045023312 catalytic residue [active] 653045023313 Transcriptional regulator [Transcription]; Region: LysR; COG0583 653045023314 Helix-turn-helix domains; Region: HTH; cl00088 653045023315 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 653045023316 dimerization interface [polypeptide binding]; other site 653045023317 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 653045023318 nudix motif; other site 653045023319 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 653045023320 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 653045023321 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 653045023322 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 653045023323 heme-binding site [chemical binding]; other site 653045023324 The oxygenase reductase FAD/NADH binding domain acts as part of the multi-component bacterial oxygenases which oxidize hydrocarbons using oxygen as the oxidant. Electron transfer is from NADH via FAD (in the oxygenase reductase) and an [2FE-2S]...; Region: O2ase_reductase_like; cd06187 653045023325 FAD binding pocket [chemical binding]; other site 653045023326 FAD binding motif [chemical binding]; other site 653045023327 phosphate binding motif [ion binding]; other site 653045023328 beta-alpha-beta structure motif; other site 653045023329 NAD binding pocket [chemical binding]; other site 653045023330 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 653045023331 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 653045023332 Transcriptional regulators [Transcription]; Region: MarR; COG1846 653045023333 Helix-turn-helix domains; Region: HTH; cl00088 653045023334 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 653045023335 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 653045023336 Coenzyme A binding pocket [chemical binding]; other site 653045023337 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045023338 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 653045023339 DNA binding residues [nucleotide binding] 653045023340 putative dimer interface [polypeptide binding]; other site 653045023341 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 653045023342 catalytic residues [active] 653045023343 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 653045023344 active site 653045023345 catalytic residues [active] 653045023346 metal binding site [ion binding]; metal-binding site 653045023347 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 653045023348 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 653045023349 S-adenosylmethionine binding site [chemical binding]; other site 653045023350 replicative DNA helicase; Region: DnaB; TIGR00665 653045023351 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 653045023352 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 653045023353 Walker A motif; other site 653045023354 ATP binding site [chemical binding]; other site 653045023355 Walker B motif; other site 653045023356 DNA binding loops [nucleotide binding] 653045023357 putative efflux protein, MATE family; Region: matE; TIGR00797 653045023358 MatE; Region: MatE; cl10513 653045023359 MatE; Region: MatE; cl10513 653045023360 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 653045023361 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 653045023362 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 653045023363 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 653045023364 dimer interface [polypeptide binding]; other site 653045023365 ssDNA binding site [nucleotide binding]; other site 653045023366 tetramer (dimer of dimers) interface [polypeptide binding]; other site 653045023367 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 653045023368 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045023369 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 653045023370 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 653045023371 catalytic residue [active] 653045023372 Protein of unknown function (DUF2029); Region: DUF2029; cl09812 653045023373 Transglycosylase; Region: Transgly; cl07896 653045023374 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 653045023375 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 653045023376 Helix-turn-helix domains; Region: HTH; cl00088 653045023377 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 653045023378 H+ Antiporter protein; Region: 2A0121; TIGR00900 653045023379 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 653045023380 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 653045023381 active site 653045023382 NTP binding site [chemical binding]; other site 653045023383 metal binding triad [ion binding]; metal-binding site 653045023384 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 653045023385 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 653045023386 Zn2+ binding site [ion binding]; other site 653045023387 Mg2+ binding site [ion binding]; other site 653045023388 MatE; Region: MatE; cl10513 653045023389 MatE; Region: MatE; cl10513 653045023390 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 653045023391 active site 653045023392 ATP binding site [chemical binding]; other site 653045023393 substrate binding site [chemical binding]; other site 653045023394 activation loop (A-loop); other site 653045023395 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 653045023396 RNA polymerase sigma factor SigM; Reviewed; Region: PRK09643 653045023397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 653045023398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 653045023399 DNA binding residues [nucleotide binding] 653045023400 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 653045023401 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 653045023402 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 653045023403 catalytic residues [active] 653045023404 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 653045023405 ParB-like partition proteins; Region: parB_part; TIGR00180 653045023406 ParB-like nuclease domain; Region: ParBc; cl02129 653045023407 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 653045023408 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 653045023409 P-loop; other site 653045023410 Magnesium ion binding site [ion binding]; other site 653045023411 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 653045023412 Magnesium ion binding site [ion binding]; other site 653045023413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 653045023414 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 653045023415 G-X-X-G motif; other site 653045023416 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 653045023417 RxxxH motif; other site 653045023418 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 653045023419 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 653045023420 Haemolytic domain; Region: Haemolytic; cl00506