-- dump date 20120504_163521 -- class Genbank::misc_feature -- table misc_feature_note -- id note 110662000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 110662000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 110662000003 putative DNA binding surface [nucleotide binding]; other site 110662000004 dimer interface [polypeptide binding]; other site 110662000005 beta-clamp/clamp loader binding surface; other site 110662000006 beta-clamp/translesion DNA polymerase binding surface; other site 110662000007 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 110662000008 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 110662000009 dimerization interface [polypeptide binding]; other site 110662000010 ATP binding site [chemical binding]; other site 110662000011 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 110662000012 dimerization interface [polypeptide binding]; other site 110662000013 ATP binding site [chemical binding]; other site 110662000014 amidophosphoribosyltransferase; Provisional; Region: PRK09246 110662000015 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 110662000016 active site 110662000017 tetramer interface [polypeptide binding]; other site 110662000018 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 110662000019 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 110662000020 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 110662000021 CAP-like domain; other site 110662000022 active site 110662000023 primary dimer interface [polypeptide binding]; other site 110662000024 Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188 110662000025 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 110662000026 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 110662000027 TPR motif; other site 110662000028 binding surface 110662000029 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662000030 binding surface 110662000031 TPR motif; other site 110662000032 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 110662000033 binding surface 110662000034 TPR motif; other site 110662000035 iron-sulfur cluster binding protein, putative; Region: TIGR00276 110662000036 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 110662000037 4Fe-4S binding domain; Region: Fer4; cl02805 110662000038 Protein of unknown function (DUF502); Region: DUF502; cl01107 110662000039 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 110662000040 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 110662000041 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 110662000042 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 110662000043 P loop; other site 110662000044 GTP binding site [chemical binding]; other site 110662000045 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 110662000046 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 110662000047 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 110662000048 argininosuccinate lyase; Provisional; Region: PRK00855 110662000049 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 110662000050 active sites [active] 110662000051 tetramer interface [polypeptide binding]; other site 110662000052 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 110662000053 RNA/DNA binding site [nucleotide binding]; other site 110662000054 RRM dimerization site [polypeptide binding]; other site 110662000055 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 110662000056 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 110662000057 FMN binding site [chemical binding]; other site 110662000058 active site 110662000059 catalytic residues [active] 110662000060 substrate binding site [chemical binding]; other site 110662000061 SelR domain; Region: SelR; cl00369 110662000062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000063 flavoprotein, HI0933 family; Region: TIGR00275 110662000064 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 110662000065 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 110662000066 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000067 Walker A motif; other site 110662000068 ATP binding site [chemical binding]; other site 110662000069 Walker B motif; other site 110662000070 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 110662000071 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 110662000072 dimer interface [polypeptide binding]; other site 110662000073 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 110662000074 chaperone protein DnaJ; Provisional; Region: PRK14293 110662000075 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 110662000076 HSP70 interaction site [polypeptide binding]; other site 110662000077 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 110662000078 substrate binding site [polypeptide binding]; other site 110662000079 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 110662000080 Zn binding sites [ion binding]; other site 110662000081 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 110662000082 dimer interface [polypeptide binding]; other site 110662000083 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 110662000084 CPxP motif; other site 110662000085 GTPase RsgA; Reviewed; Region: PRK00098 110662000086 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 110662000087 GTPase/OB domain interface [polypeptide binding]; other site 110662000088 GTPase/Zn-binding domain interface [polypeptide binding]; other site 110662000089 GTP/Mg2+ binding site [chemical binding]; other site 110662000090 G4 box; other site 110662000091 G5 box; other site 110662000092 G1 box; other site 110662000093 Switch I region; other site 110662000094 G2 box; other site 110662000095 G3 box; other site 110662000096 Switch II region; other site 110662000097 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 110662000098 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 110662000099 FAD binding domain; Region: FAD_binding_4; pfam01565 110662000100 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 110662000101 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 110662000102 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 110662000103 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 110662000104 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 110662000105 glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403 110662000106 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 110662000107 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 110662000108 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 110662000109 dimerization interface [polypeptide binding]; other site 110662000110 ATP binding site [chemical binding]; other site 110662000111 cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924 110662000112 active site 110662000113 elongation factor P; Validated; Region: PRK00529 110662000114 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 110662000115 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 110662000116 RNA binding site [nucleotide binding]; other site 110662000117 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 110662000118 RNA binding site [nucleotide binding]; other site 110662000119 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 110662000120 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 110662000121 carboxyltransferase (CT) interaction site; other site 110662000122 biotinylation site [posttranslational modification]; other site 110662000123 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 110662000124 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 110662000125 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 110662000126 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 110662000127 putative NAD(P) binding site [chemical binding]; other site 110662000128 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 110662000129 active site 110662000130 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 110662000131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662000132 ATP-binding site [chemical binding]; other site 110662000133 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662000134 TPR motif; other site 110662000135 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 110662000136 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 110662000137 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 110662000138 homodimer interface [polypeptide binding]; other site 110662000139 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662000140 catalytic residue [active] 110662000141 CbiD; Region: CbiD; cl00828 110662000142 GMP synthase; Reviewed; Region: guaA; PRK00074 110662000143 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 110662000144 AMP/PPi binding site [chemical binding]; other site 110662000145 candidate oxyanion hole; other site 110662000146 catalytic triad [active] 110662000147 potential glutamine specificity residues [chemical binding]; other site 110662000148 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 110662000149 ATP Binding subdomain [chemical binding]; other site 110662000150 Ligand Binding sites [chemical binding]; other site 110662000151 Dimerization subdomain; other site 110662000152 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662000153 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 110662000154 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 110662000155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 110662000156 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 110662000157 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 110662000158 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000159 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 110662000160 NAD(P) binding site [chemical binding]; other site 110662000161 active site 110662000162 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 110662000163 ThiS interaction site; other site 110662000164 putative active site [active] 110662000165 tetramer interface [polypeptide binding]; other site 110662000166 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662000167 binding surface 110662000168 TPR motif; other site 110662000169 ribosomal protein L20; Region: rpl20; CHL00068 110662000170 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 110662000171 23S rRNA binding site [nucleotide binding]; other site 110662000172 L21 binding site [polypeptide binding]; other site 110662000173 L13 binding site [polypeptide binding]; other site 110662000174 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 110662000175 Stage II sporulation protein; Region: SpoIID; pfam08486 110662000176 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 110662000177 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 110662000178 DXD motif; other site 110662000179 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662000180 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl01922 110662000181 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 110662000182 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662000183 Walker A motif; other site 110662000184 ATP binding site [chemical binding]; other site 110662000185 Walker B motif; other site 110662000186 arginine finger; other site 110662000187 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 110662000188 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948 110662000189 NC domain; Region: NC; pfam04970 110662000190 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 110662000191 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 110662000192 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662000194 Walker A motif; other site 110662000195 ATP binding site [chemical binding]; other site 110662000196 Walker B motif; other site 110662000197 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 110662000198 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 110662000199 oligomer interface [polypeptide binding]; other site 110662000200 active site residues [active] 110662000201 trigger factor; Provisional; Region: tig; PRK01490 110662000202 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 110662000203 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 110662000204 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 110662000205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000206 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 110662000207 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 110662000208 dihydrodipicolinate synthase; Region: dapA; TIGR00674 110662000209 dimer interface [polypeptide binding]; other site 110662000210 active site 110662000211 catalytic residue [active] 110662000212 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 110662000213 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662000214 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 110662000215 aspartate kinase; Provisional; Region: PRK07431 110662000216 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 110662000217 putative nucleotide binding site [chemical binding]; other site 110662000218 putative catalytic residues [active] 110662000219 putative Mg ion binding site [ion binding]; other site 110662000220 putative aspartate binding site [chemical binding]; other site 110662000221 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 110662000222 putative allosteric regulatory site; other site 110662000223 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 110662000224 putative allosteric regulatory residue; other site 110662000225 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 110662000226 putative allosteric regulatory site; other site 110662000227 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 110662000228 putative allosteric regulatory residue; other site 110662000229 DNA polymerase III subunit delta; Validated; Region: PRK07452 110662000230 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 110662000231 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 110662000232 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 110662000233 Ligand Binding Site [chemical binding]; other site 110662000234 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 110662000235 YCF9; Region: Ycf9; cl09269 110662000236 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 110662000237 homopentamer interface [polypeptide binding]; other site 110662000238 active site 110662000239 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 110662000240 MutS domain I; Region: MutS_I; pfam01624 110662000241 MutS domain II; Region: MutS_II; pfam05188 110662000242 MutS family domain IV; Region: MutS_IV; pfam05190 110662000243 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 110662000244 Walker A/P-loop; other site 110662000245 ATP binding site [chemical binding]; other site 110662000246 Q-loop/lid; other site 110662000247 ABC transporter signature motif; other site 110662000248 Walker B; other site 110662000249 D-loop; other site 110662000250 H-loop/switch region; other site 110662000251 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662000252 excinuclease ABC subunit B; Provisional; Region: PRK05298 110662000253 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662000254 ATP binding site [chemical binding]; other site 110662000255 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662000256 nucleotide binding region [chemical binding]; other site 110662000257 ATP-binding site [chemical binding]; other site 110662000258 Ultra-violet resistance protein B; Region: UvrB; pfam12344 110662000259 UvrB/uvrC motif; Region: UVR; pfam02151 110662000260 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902 110662000261 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000262 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 110662000263 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 110662000264 serine O-acetyltransferase; Region: cysE; TIGR01172 110662000265 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 110662000266 trimer interface [polypeptide binding]; other site 110662000267 active site 110662000268 substrate binding site [chemical binding]; other site 110662000269 Acyl-[acyl carrier protein]; Region: LpxA; COG1043 110662000270 CoA binding site [chemical binding]; other site 110662000271 Predicted transcriptional regulators [Transcription]; Region: COG1725 110662000272 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 110662000273 DNA-binding site [nucleotide binding]; DNA binding site 110662000274 Dienelactone hydrolase family; Region: DLH; pfam01738 110662000275 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 110662000276 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 110662000277 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 110662000278 IPP transferase; Region: IPPT; cl00403 110662000279 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 110662000280 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 110662000281 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 110662000282 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 110662000283 anchoring element; other site 110662000284 dimer interface [polypeptide binding]; other site 110662000285 ATP binding site [chemical binding]; other site 110662000286 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 110662000287 active site 110662000288 putative metal-binding site [ion binding]; other site 110662000289 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 110662000290 CrcB-like protein; Region: CRCB; cl09114 110662000291 CrcB-like protein; Region: CRCB; cl09114 110662000292 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 110662000293 catalytic residues [active] 110662000294 dimer interface [polypeptide binding]; other site 110662000295 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 110662000296 MgtE intracellular N domain; Region: MgtE_N; cl15244 110662000297 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 110662000298 Divalent cation transporter; Region: MgtE; cl00786 110662000299 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 110662000300 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 110662000301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662000302 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 110662000303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 110662000304 hydrolase, alpha/beta fold family protein; Region: PLN02824 110662000305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662000306 MoxR-like ATPases [General function prediction only]; Region: COG0714 110662000307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662000308 Walker A motif; other site 110662000309 ATP binding site [chemical binding]; other site 110662000310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000311 Walker B motif; other site 110662000312 arginine finger; other site 110662000313 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 110662000314 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 110662000315 minor groove reading motif; other site 110662000316 helix-hairpin-helix signature motif; other site 110662000317 substrate binding pocket [chemical binding]; other site 110662000318 active site 110662000319 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 110662000320 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 110662000321 active site 110662000322 8-oxo-dGMP binding site [chemical binding]; other site 110662000323 nudix motif; other site 110662000324 metal binding site [ion binding]; metal-binding site 110662000325 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 110662000326 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 110662000327 putative substrate binding site [chemical binding]; other site 110662000328 putative ATP binding site [chemical binding]; other site 110662000329 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 110662000330 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 110662000331 S-adenosyl-L-homocysteine hydrolase (AdoHycase) catalyzes the hydrolysis of S-adenosyl-L-homocysteine (AdoHyc) to form adenosine (Ado) and homocysteine (Hcy). The equilibrium lies far on the side of AdoHyc synthesis, but in nature the removal of Ado and...; Region: AdoHcyase; cd00401 110662000332 oligomerization interface [polypeptide binding]; other site 110662000333 active site 110662000334 NAD+ binding site [chemical binding]; other site 110662000335 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 110662000336 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 110662000337 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 110662000338 dimer interface [polypeptide binding]; other site 110662000339 ssDNA binding site [nucleotide binding]; other site 110662000340 tetramer (dimer of dimers) interface [polypeptide binding]; other site 110662000341 rod shape-determining protein MreB; Provisional; Region: PRK13927 110662000342 Cell division protein FtsA; Region: FtsA; cl11496 110662000343 rod shape-determining protein MreC; Region: MreC; pfam04085 110662000344 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 110662000345 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 110662000346 Ycf27; Reviewed; Region: orf27; CHL00148 110662000347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662000348 active site 110662000349 phosphorylation site [posttranslational modification] 110662000350 intermolecular recognition site; other site 110662000351 dimerization interface [polypeptide binding]; other site 110662000352 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662000353 DNA binding site [nucleotide binding] 110662000354 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 110662000355 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 110662000356 dimer interface [polypeptide binding]; other site 110662000357 putative anticodon binding site; other site 110662000358 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 110662000359 motif 1; other site 110662000360 active site 110662000361 motif 2; other site 110662000362 motif 3; other site 110662000363 probable methyltransferase; Region: TIGR03438 110662000364 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 110662000365 TIGR03440 family protein; Region: unchr_TIGR03440 110662000366 DinB superfamily; Region: DinB_2; cl00986 110662000367 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 110662000368 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 110662000369 SmpB-tmRNA interface; other site 110662000370 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 110662000371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662000372 Walker A motif; other site 110662000373 ATP binding site [chemical binding]; other site 110662000374 Walker B motif; other site 110662000375 arginine finger; other site 110662000376 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 110662000377 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cl08294 110662000378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662000379 binding surface 110662000380 TPR motif; other site 110662000381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662000382 binding surface 110662000383 TPR motif; other site 110662000384 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 110662000385 amidohydrolase; Region: amidohydrolases; TIGR01891 110662000386 metal binding site [ion binding]; metal-binding site 110662000387 dimer interface [polypeptide binding]; other site 110662000388 Protein of unknown function (DUF3188); Region: DUF3188; pfam11384 110662000389 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 110662000390 ThiC family; Region: ThiC; cl08031 110662000391 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 110662000392 transketolase; Region: PLN02790 110662000393 TPP-binding site [chemical binding]; other site 110662000394 dimer interface [polypeptide binding]; other site 110662000395 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 110662000396 PYR/PP interface [polypeptide binding]; other site 110662000397 dimer interface [polypeptide binding]; other site 110662000398 TPP binding site [chemical binding]; other site 110662000399 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 110662000400 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 110662000401 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 110662000402 dimer interface [polypeptide binding]; other site 110662000403 active site 110662000404 Phosphopantetheine attachment site; Region: PP-binding; cl09936 110662000405 photosystem I subunit VII; Region: psaC; CHL00065 110662000406 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 110662000407 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 110662000408 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 110662000409 glutaminase active site [active] 110662000410 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 110662000411 dimer interface [polypeptide binding]; other site 110662000412 active site 110662000413 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 110662000414 dimer interface [polypeptide binding]; other site 110662000415 active site 110662000416 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 110662000417 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 110662000418 Substrate binding site; other site 110662000419 Cupin domain; Region: Cupin_2; cl09118 110662000420 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 110662000421 RimM N-terminal domain; Region: RimM; pfam01782 110662000422 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 110662000423 Protein of unknown function (DUF3252); Region: DUF3252; pfam11623 110662000424 Ion transport protein; Region: Ion_trans; pfam00520 110662000425 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 110662000426 Ion channel; Region: Ion_trans_2; cl11596 110662000427 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 110662000428 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 110662000429 Alcohol dehydrogenase-like; Region: PLN02740 110662000430 NeuB family; Region: NeuB; cl00496 110662000431 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 110662000432 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 110662000433 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662000434 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 110662000435 Ligand binding site; other site 110662000436 oligomer interface; other site 110662000437 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662000438 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000439 NAD(P) binding site [chemical binding]; other site 110662000440 active site 110662000441 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662000442 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 110662000443 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 110662000444 dimerization interface [polypeptide binding]; other site 110662000445 active site 110662000446 metal binding site [ion binding]; metal-binding site 110662000447 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 110662000448 dsRNA binding site [nucleotide binding]; other site 110662000449 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 110662000450 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 110662000451 homodimer interface [polypeptide binding]; other site 110662000452 active site pocket [active] 110662000453 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 110662000454 hydrolase; Region: PLN02578 110662000455 Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025 110662000456 Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017 110662000457 active site 110662000458 catalytic residues [active] 110662000459 FAD binding domain; Region: FAD_binding_4; pfam01565 110662000460 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 110662000461 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 110662000462 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 110662000463 Cysteine-rich domain; Region: CCG; pfam02754 110662000464 Cysteine-rich domain; Region: CCG; pfam02754 110662000465 isocitrate dehydrogenase; Validated; Region: PRK07362 110662000466 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 110662000467 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 110662000468 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 110662000469 Ligand binding site; other site 110662000470 Putative Catalytic site; other site 110662000471 DXD motif; other site 110662000472 GtrA-like protein; Region: GtrA; cl00971 110662000473 YdjC-like protein; Region: YdjC; cl01344 110662000474 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 110662000475 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 110662000476 heme binding pocket [chemical binding]; other site 110662000477 heme ligand [chemical binding]; other site 110662000478 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662000479 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 110662000480 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662000481 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000482 Walker A/P-loop; other site 110662000483 ATP binding site [chemical binding]; other site 110662000484 Q-loop/lid; other site 110662000485 ABC transporter signature motif; other site 110662000486 Walker B; other site 110662000487 D-loop; other site 110662000488 H-loop/switch region; other site 110662000489 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 110662000490 putative homodimer interface [polypeptide binding]; other site 110662000491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 110662000492 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 110662000493 putative ADP-binding pocket [chemical binding]; other site 110662000494 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 110662000495 putative ADP-binding pocket [chemical binding]; other site 110662000496 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844 110662000497 putative ADP-binding pocket [chemical binding]; other site 110662000498 Sulfotransferase family; Region: Sulfotransfer_3; cl14559 110662000499 NeuB family; Region: NeuB; cl00496 110662000500 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 110662000501 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 110662000502 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 110662000503 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000504 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000505 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 110662000506 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662000507 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 110662000508 Ligand binding site; other site 110662000509 oligomer interface; other site 110662000510 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 110662000511 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 110662000512 heme binding site [chemical binding]; other site 110662000513 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 110662000514 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 110662000515 motif II; other site 110662000516 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 110662000517 KpsF/GutQ family protein; Region: kpsF; TIGR00393 110662000518 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 110662000519 putative active site [active] 110662000520 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 110662000521 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 110662000522 active site 110662000523 NTP binding site [chemical binding]; other site 110662000524 metal binding triad [ion binding]; metal-binding site 110662000525 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 110662000526 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 110662000527 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 110662000528 dimerization interface [polypeptide binding]; other site 110662000529 putative ATP binding site [chemical binding]; other site 110662000530 UDP-glucose 4-epimerase; Region: PLN02240 110662000531 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 110662000532 NAD binding site [chemical binding]; other site 110662000533 homodimer interface [polypeptide binding]; other site 110662000534 active site 110662000535 substrate binding site [chemical binding]; other site 110662000536 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 110662000537 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 110662000538 dimer interface [polypeptide binding]; other site 110662000539 motif 1; other site 110662000540 active site 110662000541 motif 2; other site 110662000542 motif 3; other site 110662000543 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 110662000544 anticodon binding site; other site 110662000545 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 110662000546 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 110662000547 NAD binding site [chemical binding]; other site 110662000548 putative substrate binding site 2 [chemical binding]; other site 110662000549 putative substrate binding site 1 [chemical binding]; other site 110662000550 active site 110662000551 probable UDP-glucose 6-dehydrogenase; Region: PLN02353 110662000552 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 110662000553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000554 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 110662000555 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 110662000556 putative NAD(P) binding site [chemical binding]; other site 110662000557 active site 110662000558 putative substrate binding site [chemical binding]; other site 110662000559 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 110662000560 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662000561 active site 110662000562 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662000563 Rhamnan synthesis protein F; Region: RgpF; cl01529 110662000564 PsbJ; Region: PsbJ; cl09469 110662000565 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 110662000566 cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557 110662000567 Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834 110662000568 Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284 110662000569 Ycf48-like protein; Provisional; Region: PRK13684 110662000570 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 110662000571 Rubredoxin [Energy production and conversion]; Region: COG1773 110662000572 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 110662000573 iron binding site [ion binding]; other site 110662000574 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 110662000575 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 110662000576 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 110662000577 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 110662000578 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 110662000579 phosphate binding site [ion binding]; other site 110662000580 putative substrate binding pocket [chemical binding]; other site 110662000581 dimer interface [polypeptide binding]; other site 110662000582 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000583 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 110662000584 Walker A/P-loop; other site 110662000585 ATP binding site [chemical binding]; other site 110662000586 Q-loop/lid; other site 110662000587 ABC transporter signature motif; other site 110662000588 Walker B; other site 110662000589 D-loop; other site 110662000590 H-loop/switch region; other site 110662000591 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 110662000592 mce related protein; Region: MCE; cl15431 110662000593 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000594 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 110662000595 Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240 110662000596 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451 110662000597 metal ion-dependent adhesion site (MIDAS); other site 110662000598 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 110662000599 catalytic center binding site [active] 110662000600 ATP binding site [chemical binding]; other site 110662000601 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 110662000602 dimer interface [polypeptide binding]; other site 110662000603 ADP-ribose binding site [chemical binding]; other site 110662000604 active site 110662000605 nudix motif; other site 110662000606 metal binding site [ion binding]; metal-binding site 110662000607 deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556 110662000608 DNA photolyase; Region: DNA_photolyase; pfam00875 110662000609 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 110662000610 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 110662000611 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 110662000612 inhibitor-cofactor binding pocket; inhibition site 110662000613 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662000614 catalytic residue [active] 110662000615 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 110662000616 putative catalytic residue [active] 110662000617 DNA photolyase; Region: DNA_photolyase; pfam00875 110662000618 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 110662000619 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 110662000620 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 110662000621 NAD binding site [chemical binding]; other site 110662000622 homotetramer interface [polypeptide binding]; other site 110662000623 homodimer interface [polypeptide binding]; other site 110662000624 substrate binding site [chemical binding]; other site 110662000625 active site 110662000626 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 110662000627 putative active site pocket [active] 110662000628 4-fold oligomerization interface [polypeptide binding]; other site 110662000629 metal binding residues [ion binding]; metal-binding site 110662000630 3-fold/trimer interface [polypeptide binding]; other site 110662000631 Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670 110662000632 Retinal pigment epithelial membrane protein; Region: RPE65; cl10080 110662000633 Protein of unknown function (DUF541); Region: SIMPL; cl01077 110662000634 BCCT family transporter; Region: BCCT; cl00569 110662000635 sarcosine oxidase, monomeric form; Region: soxA_mon; TIGR01377 110662000636 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000637 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 110662000638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000639 NAD(P) binding pocket [chemical binding]; other site 110662000640 SAM dependent carboxyl methyltransferase; Region: Methyltransf_7; cl04109 110662000641 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 110662000642 active site 110662000643 dimerization interface [polypeptide binding]; other site 110662000644 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 110662000645 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 110662000646 active site 110662000647 substrate binding site [chemical binding]; other site 110662000648 metal binding site [ion binding]; metal-binding site 110662000649 RecB family nuclease, putative, TM0106 family; Region: TIGR03491 110662000650 Y-family of DNA polymerases; Region: PolY; cl12025 110662000651 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 110662000652 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 110662000653 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 110662000654 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 110662000655 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 110662000656 Domain of unknown function DUF21; Region: DUF21; pfam01595 110662000657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 110662000658 Transporter associated domain; Region: CorC_HlyC; cl08393 110662000659 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 110662000660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000661 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 110662000662 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 110662000663 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 110662000664 Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641 110662000665 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 110662000666 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 110662000667 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 110662000668 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 110662000669 dimer interface [polypeptide binding]; other site 110662000670 phosphorylation site [posttranslational modification] 110662000671 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 110662000672 ATP binding site [chemical binding]; other site 110662000673 Mg2+ binding site [ion binding]; other site 110662000674 G-X-G motif; other site 110662000675 Protein of unknown function (DUF3155); Region: DUF3155; pfam11352 110662000676 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 110662000677 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662000678 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662000679 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 110662000680 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 110662000681 purine monophosphate binding site [chemical binding]; other site 110662000682 dimer interface [polypeptide binding]; other site 110662000683 putative catalytic residues [active] 110662000684 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 110662000685 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 110662000686 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 110662000687 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 110662000688 LytB protein; Region: LYTB; cl00507 110662000689 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 110662000690 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 110662000691 Sugar fermentation stimulation protein; Region: SfsA; cl00647 110662000692 integral membrane protein MviN; Region: mviN; TIGR01695 110662000693 MatE; Region: MatE; cl10513 110662000694 Protein of unknown function (DUF3181); Region: DUF3181; pfam11378 110662000695 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 110662000696 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 110662000697 dimer interface [polypeptide binding]; other site 110662000698 glycine-pyridoxal phosphate binding site [chemical binding]; other site 110662000699 active site 110662000700 folate binding site [chemical binding]; other site 110662000701 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 110662000702 Mg++ binding site [ion binding]; other site 110662000703 putative catalytic motif [active] 110662000704 substrate binding site [chemical binding]; other site 110662000705 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 110662000706 competence damage-inducible protein A; Provisional; Region: PRK00549 110662000707 putative MPT binding site; other site 110662000708 Competence-damaged protein; Region: CinA; cl00666 110662000709 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 110662000710 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 110662000711 substrate binding site [chemical binding]; other site 110662000712 ligand binding site [chemical binding]; other site 110662000713 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 110662000714 substrate binding site [chemical binding]; other site 110662000715 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662000716 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662000717 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 110662000718 Protein of unknown function (DUF3769); Region: DUF3769; pfam12600 110662000719 Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640 110662000720 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 110662000721 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 110662000722 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 110662000723 Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605 110662000724 Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951 110662000725 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 110662000726 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 110662000727 putative active site [active] 110662000728 catalytic residue [active] 110662000729 Protein of unknown function (DUF3146); Region: DUF3146; pfam11344 110662000730 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 110662000731 Protein of unknown function (DUF3084); Region: DUF3084; pfam11283 110662000732 Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372 110662000733 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 110662000734 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 110662000735 ligand binding site [chemical binding]; other site 110662000736 flexible hinge region; other site 110662000737 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 110662000738 putative switch regulator; other site 110662000739 non-specific DNA interactions [nucleotide binding]; other site 110662000740 DNA binding site [nucleotide binding] 110662000741 sequence specific DNA binding site [nucleotide binding]; other site 110662000742 putative cAMP binding site [chemical binding]; other site 110662000743 ribonuclease PH; Reviewed; Region: rph; PRK00173 110662000744 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 110662000745 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 110662000746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662000747 Walker A motif; other site 110662000748 ATP binding site [chemical binding]; other site 110662000749 Walker B motif; other site 110662000750 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 110662000751 trimer interface [polypeptide binding]; other site 110662000752 active site 110662000753 Thymidylate synthase complementing protein; Region: Thy1; cl03630 110662000754 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 110662000755 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 110662000756 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 110662000757 N-acetyl-D-glucosamine binding site [chemical binding]; other site 110662000758 catalytic residue [active] 110662000759 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317 110662000760 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 110662000761 active site 110662000762 substrate binding site [chemical binding]; other site 110662000763 metal binding site [ion binding]; metal-binding site 110662000764 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 110662000765 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 110662000766 O-Antigen ligase; Region: Wzy_C; cl04850 110662000767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662000768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 110662000769 FIST N domain; Region: FIST; cl10701 110662000770 FIST C domain; Region: FIST_C; pfam10442 110662000771 Protein of unknown function (DUF3177); Region: DUF3177; pfam11375 110662000772 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 110662000773 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 110662000774 active site 110662000775 HIGH motif; other site 110662000776 nucleotide binding site [chemical binding]; other site 110662000777 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 110662000778 active site 110662000779 KMSKS motif; other site 110662000780 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 110662000781 tRNA binding surface [nucleotide binding]; other site 110662000782 anticodon binding site; other site 110662000783 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 110662000784 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 110662000785 Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514 110662000786 putative di-iron ligands [ion binding]; other site 110662000787 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 110662000788 Creatinine amidohydrolase; Region: Creatininase; cl00618 110662000789 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 110662000790 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 110662000791 active site 110662000792 DNA binding site [nucleotide binding] 110662000793 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 110662000794 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 110662000795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000797 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 110662000798 ATP binding site [chemical binding]; other site 110662000799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662000800 Protein of unknown function (DUF565); Region: DUF565; pfam04483 110662000801 Protein of unknown function (DUF2555); Region: DUF2555; pfam10742 110662000802 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 110662000803 Flavoprotein; Region: Flavoprotein; cl08021 110662000804 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 110662000805 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 110662000806 Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326 110662000807 ATP-sulfurylase; Region: ATPS; cd00517 110662000808 active site 110662000809 HXXH motif; other site 110662000810 flexible loop; other site 110662000811 FtsH Extracellular; Region: FtsH_ext; pfam06480 110662000812 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 110662000813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662000814 Walker A motif; other site 110662000815 ATP binding site [chemical binding]; other site 110662000816 Walker B motif; other site 110662000817 arginine finger; other site 110662000818 Peptidase family M41; Region: Peptidase_M41; pfam01434 110662000819 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 110662000820 active site 110662000821 intersubunit interface [polypeptide binding]; other site 110662000822 catalytic residue [active] 110662000823 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 110662000824 Tetramer interface [polypeptide binding]; other site 110662000825 active site 110662000826 FMN-binding site [chemical binding]; other site 110662000827 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 110662000828 Cupin domain; Region: Cupin_2; cl09118 110662000829 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 110662000830 protein I interface; other site 110662000831 D2 interface; other site 110662000832 protein T interface; other site 110662000833 chlorophyll binding site; other site 110662000834 beta carotene binding site; other site 110662000835 pheophytin binding site; other site 110662000836 manganese-stabilizing polypeptide interface; other site 110662000837 CP43 interface; other site 110662000838 protein L interface; other site 110662000839 oxygen evolving complex binding site; other site 110662000840 bromide binding site; other site 110662000841 quinone binding site; other site 110662000842 Fe binding site [ion binding]; other site 110662000843 core light harvesting interface; other site 110662000844 cytochrome b559 alpha subunit interface; other site 110662000845 cytochrome c-550 interface; other site 110662000846 protein J interface; other site 110662000847 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 110662000848 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 110662000849 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662000850 FeS/SAM binding site; other site 110662000851 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 110662000852 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 110662000853 LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542 110662000854 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 110662000855 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662000856 homodimer interface [polypeptide binding]; other site 110662000857 catalytic residue [active] 110662000858 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 110662000859 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 110662000860 B12 binding site [chemical binding]; other site 110662000861 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 110662000862 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 110662000863 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 110662000864 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 110662000865 homodimer interface [polypeptide binding]; other site 110662000866 oligonucleotide binding site [chemical binding]; other site 110662000867 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 110662000868 RNA/DNA hybrid binding site [nucleotide binding]; other site 110662000869 active site 110662000870 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 110662000871 prephenate dehydratase; Provisional; Region: PRK11898 110662000872 Prephenate dehydratase; Region: PDT; pfam00800 110662000873 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 110662000874 putative L-Phe binding site [chemical binding]; other site 110662000875 tocopherol O-methyltransferase; Region: PLN02244 110662000876 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662000877 S-adenosylmethionine binding site [chemical binding]; other site 110662000878 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 110662000879 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 110662000880 elongation factor Tu; Reviewed; Region: PRK00049 110662000881 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 110662000882 G1 box; other site 110662000883 GEF interaction site [polypeptide binding]; other site 110662000884 GTP/Mg2+ binding site [chemical binding]; other site 110662000885 Switch I region; other site 110662000886 G2 box; other site 110662000887 G3 box; other site 110662000888 Switch II region; other site 110662000889 G4 box; other site 110662000890 G5 box; other site 110662000891 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 110662000892 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 110662000893 Antibiotic Binding Site [chemical binding]; other site 110662000894 elongation factor G; Reviewed; Region: PRK00007 110662000895 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 110662000896 G1 box; other site 110662000897 putative GEF interaction site [polypeptide binding]; other site 110662000898 GTP/Mg2+ binding site [chemical binding]; other site 110662000899 Switch I region; other site 110662000900 G2 box; other site 110662000901 G3 box; other site 110662000902 Switch II region; other site 110662000903 G4 box; other site 110662000904 G5 box; other site 110662000905 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 110662000906 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 110662000907 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 110662000908 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 110662000909 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 110662000910 S17 interaction site [polypeptide binding]; other site 110662000911 S8 interaction site; other site 110662000912 16S rRNA interaction site [nucleotide binding]; other site 110662000913 streptomycin interaction site [chemical binding]; other site 110662000914 23S rRNA interaction site [nucleotide binding]; other site 110662000915 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 110662000916 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 110662000917 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 110662000918 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 110662000919 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 110662000920 active site 110662000921 dimer interface [polypeptide binding]; other site 110662000922 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 110662000923 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 110662000924 active site 110662000925 FMN binding site [chemical binding]; other site 110662000926 substrate binding site [chemical binding]; other site 110662000927 3Fe-4S cluster binding site [ion binding]; other site 110662000928 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 110662000929 domain interface; other site 110662000930 YCII-related domain; Region: YCII; cl00999 110662000931 lipoyl synthase; Provisional; Region: PRK05481 110662000932 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662000933 FeS/SAM binding site; other site 110662000934 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 110662000935 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 110662000936 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 110662000937 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 110662000938 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 110662000939 Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224 110662000940 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 110662000941 gentisate 1,2-dioxygenase; Region: gentisate_1_2; TIGR02272 110662000942 Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435 110662000943 Cupin domain; Region: Cupin_2; cl09118 110662000944 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 110662000945 Photosystem I reaction centre subunit XI; Region: PsaL; cl03651 110662000946 Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205 110662000947 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 110662000948 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 110662000949 Ligand binding site; other site 110662000950 Putative Catalytic site; other site 110662000951 DXD motif; other site 110662000952 NlpC/P60 family; Region: NLPC_P60; cl11438 110662000953 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 110662000954 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662000955 active site 110662000956 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 110662000957 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 110662000958 Protein of unknown function (DUF563); Region: DUF563; cl15705 110662000959 alanine racemase; Reviewed; Region: alr; PRK00053 110662000960 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 110662000961 active site 110662000962 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 110662000963 dimer interface [polypeptide binding]; other site 110662000964 substrate binding site [chemical binding]; other site 110662000965 catalytic residues [active] 110662000966 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 110662000967 active site 110662000968 peptide chain release factor 1; Validated; Region: prfA; PRK00591 110662000969 RF-1 domain; Region: RF-1; cl02875 110662000970 RF-1 domain; Region: RF-1; cl02875 110662000971 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 110662000972 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 110662000973 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 110662000974 23S rRNA interface [nucleotide binding]; other site 110662000975 L3 interface [polypeptide binding]; other site 110662000976 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 110662000977 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 110662000978 dimerization interface 3.5A [polypeptide binding]; other site 110662000979 active site 110662000980 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 110662000981 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 110662000982 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 110662000983 alphaNTD homodimer interface [polypeptide binding]; other site 110662000984 alphaNTD - beta interaction site [polypeptide binding]; other site 110662000985 alphaNTD - beta' interaction site [polypeptide binding]; other site 110662000986 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 110662000987 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 110662000988 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 110662000989 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 110662000990 adenylate kinase; Provisional; Region: PRK14531 110662000991 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 110662000992 AMP-binding site [chemical binding]; other site 110662000993 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 110662000994 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 110662000995 SecY translocase; Region: SecY; pfam00344 110662000996 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 110662000997 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 110662000998 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 110662000999 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 110662001000 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 110662001001 5S rRNA interface [nucleotide binding]; other site 110662001002 L27 interface [polypeptide binding]; other site 110662001003 23S rRNA interface [nucleotide binding]; other site 110662001004 L5 interface [polypeptide binding]; other site 110662001005 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 110662001006 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 110662001007 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 110662001008 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 110662001009 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 110662001010 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 110662001011 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 110662001012 KOW motif; Region: KOW; cl00354 110662001013 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 110662001014 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 110662001015 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 110662001016 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 110662001017 23S rRNA interface [nucleotide binding]; other site 110662001018 putative translocon interaction site; other site 110662001019 signal recognition particle (SRP54) interaction site; other site 110662001020 L23 interface [polypeptide binding]; other site 110662001021 trigger factor interaction site; other site 110662001022 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 110662001023 23S rRNA interface [nucleotide binding]; other site 110662001024 5S rRNA interface [nucleotide binding]; other site 110662001025 putative antibiotic binding site [chemical binding]; other site 110662001026 L25 interface [polypeptide binding]; other site 110662001027 L27 interface [polypeptide binding]; other site 110662001028 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 110662001029 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 110662001030 G-X-X-G motif; other site 110662001031 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 110662001032 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 110662001033 putative translocon binding site; other site 110662001034 protein-rRNA interface [nucleotide binding]; other site 110662001035 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 110662001036 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 110662001037 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 110662001038 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 110662001039 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 110662001040 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 110662001041 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 110662001042 NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909 110662001043 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 110662001044 4Fe-4S binding domain; Region: Fer4; cl02805 110662001045 Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617 110662001046 ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854 110662001047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662001048 Walker A motif; other site 110662001049 ATP binding site [chemical binding]; other site 110662001050 Walker B motif; other site 110662001051 R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645 110662001052 RxxxH motif; other site 110662001053 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 110662001054 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 110662001055 recombinase A; Provisional; Region: recA; PRK09354 110662001056 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 110662001057 hexamer interface [polypeptide binding]; other site 110662001058 Walker A motif; other site 110662001059 ATP binding site [chemical binding]; other site 110662001060 Walker B motif; other site 110662001061 Domain of unknown function (DUF1815); Region: DUF1815; pfam08844 110662001062 Protein of unknown function (DUF2839); Region: DUF2839; pfam10999 110662001063 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 110662001064 arogenate dehydrogenase; Reviewed; Region: PRK07417 110662001065 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001066 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 110662001067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001068 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 110662001069 Phosphotransferase enzyme family; Region: APH; pfam01636 110662001070 Domain of unknown function (DUF4308); Region: DUF4308; cl14566 110662001071 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 110662001072 MPN+ (JAMM) motif; other site 110662001073 Zinc-binding site [ion binding]; other site 110662001074 hypothetical protein; Validated; Region: PRK07411 110662001075 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 110662001076 ATP binding site [chemical binding]; other site 110662001077 substrate interface [chemical binding]; other site 110662001078 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 110662001079 active site residue [active] 110662001080 hypothetical protein; Validated; Region: PRK07413 110662001081 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001082 Walker A motif; other site 110662001083 ATP binding site [chemical binding]; other site 110662001084 Walker B motif; other site 110662001085 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001086 Walker A motif; other site 110662001087 ATP binding site [chemical binding]; other site 110662001088 Walker B motif; other site 110662001089 TIGR00268 family protein; Region: TIGR00268 110662001090 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 110662001091 Ligand Binding Site [chemical binding]; other site 110662001092 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 110662001093 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 110662001094 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001095 Walker A/P-loop; other site 110662001096 ATP binding site [chemical binding]; other site 110662001097 Q-loop/lid; other site 110662001098 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001099 ABC transporter signature motif; other site 110662001100 Walker B; other site 110662001101 D-loop; other site 110662001102 H-loop/switch region; other site 110662001103 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 110662001104 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 110662001105 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 110662001106 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 110662001107 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 110662001108 chorismate binding enzyme; Region: Chorismate_bind; cl10555 110662001109 PsaD; Region: PsaD; cl03639 110662001110 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 110662001111 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 110662001112 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433 110662001113 Protein of unknown function (DUF3529); Region: DUF3529; pfam12046 110662001114 Helix-turn-helix domains; Region: HTH; cl00088 110662001115 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 110662001116 putative active site [active] 110662001117 catalytic site [active] 110662001118 putative substrate binding site [chemical binding]; other site 110662001119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 110662001120 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662001121 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 110662001122 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 110662001123 active site 110662001124 catalytic tetrad [active] 110662001125 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 110662001126 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 110662001127 dimerization interface [polypeptide binding]; other site 110662001128 putative ATP binding site [chemical binding]; other site 110662001129 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 110662001130 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 110662001131 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 110662001132 active site 110662001133 nucleotide binding site [chemical binding]; other site 110662001134 HIGH motif; other site 110662001135 KMSKS motif; other site 110662001136 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 110662001137 CMP-binding site; other site 110662001138 The sites determining sugar specificity; other site 110662001139 Low molecular weight phosphatase family; Region: LMWPc; cd00115 110662001140 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 110662001141 active site 110662001142 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 110662001143 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 110662001144 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 110662001145 Phycobilisome protein; Region: Phycobilisome; cl08227 110662001146 Phycobilisome protein; Region: Phycobilisome; cl08227 110662001147 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 110662001148 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 110662001149 CpeS-like protein; Region: CpeS; pfam09367 110662001150 Phycobilisome protein; Region: Phycobilisome; cl08227 110662001151 Phycobilisome protein; Region: Phycobilisome; cl08227 110662001152 Protein of unknown function (DUF2656); Region: DUF2656; pfam10847 110662001153 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 110662001154 protein binding surface [polypeptide binding]; other site 110662001155 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 110662001156 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 110662001157 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 110662001158 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662001159 Phycobilisome protein; Region: Phycobilisome; cl08227 110662001160 Phycobilisome protein; Region: Phycobilisome; cl08227 110662001161 RNA polymerase factor sigma-70; Validated; Region: PRK09047 110662001162 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 110662001163 CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206 110662001164 CpeS-like protein; Region: CpeS; pfam09367 110662001165 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662001166 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 110662001167 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662001168 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662001169 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 110662001170 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662001171 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 110662001172 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 110662001173 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662001174 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662001175 Phycobilisome protein; Region: Phycobilisome; cl08227 110662001176 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 110662001177 large terminase protein; Provisional; Region: 17; PHA02533 110662001178 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 110662001179 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 110662001180 DNA utilization protein GntX; Provisional; Region: PRK11595 110662001181 Protein of unknown function (DUF2470); Region: DUF2470; pfam10615 110662001182 D-xylulose kinase; Region: XylB; TIGR01312 110662001183 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 110662001184 N- and C-terminal domain interface [polypeptide binding]; other site 110662001185 active site 110662001186 MgATP binding site [chemical binding]; other site 110662001187 catalytic site [active] 110662001188 metal binding site [ion binding]; metal-binding site 110662001189 carbohydrate binding site [chemical binding]; other site 110662001190 S-adenosylmethionine synthetase; Validated; Region: PRK05250 110662001191 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 110662001192 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 110662001193 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 110662001194 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 110662001195 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 110662001196 active site 110662001197 motif I; other site 110662001198 motif II; other site 110662001199 30S ribosomal protein S1; Reviewed; Region: PRK07400 110662001200 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 110662001201 RNA binding site [nucleotide binding]; other site 110662001202 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 110662001203 RNA binding site [nucleotide binding]; other site 110662001204 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 110662001205 RNA binding site [nucleotide binding]; other site 110662001206 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 110662001207 ATP cone domain; Region: ATP-cone; pfam03477 110662001208 Photosystem II protein; Region: PSII; cl08223 110662001209 Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459 110662001210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 110662001211 Ligand Binding Site [chemical binding]; other site 110662001212 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 110662001213 Ligand Binding Site [chemical binding]; other site 110662001214 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 110662001215 active site 110662001216 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 110662001217 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 110662001218 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 110662001219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662001220 S-adenosylmethionine binding site [chemical binding]; other site 110662001221 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 110662001222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 110662001223 dimerization interface [polypeptide binding]; other site 110662001224 DNA binding residues [nucleotide binding] 110662001225 Septum formation topological specificity factor MinE; Region: MinE; cl00538 110662001226 septum site-determining protein MinD; Region: minD_bact; TIGR01968 110662001227 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 110662001228 P-loop; other site 110662001229 ADP binding residues [chemical binding]; other site 110662001230 Switch I; other site 110662001231 Switch II; other site 110662001232 Septum formation inhibitor [Cell division and chromosome partitioning]; Region: MinC; COG0850 110662001233 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 110662001234 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 110662001235 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 110662001236 Zn2+ binding site [ion binding]; other site 110662001237 Mg2+ binding site [ion binding]; other site 110662001238 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 110662001239 C-terminal peptidase (prc); Region: prc; TIGR00225 110662001240 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 110662001241 protein binding site [polypeptide binding]; other site 110662001242 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 110662001243 Catalytic dyad [active] 110662001244 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 110662001245 Qi binding site; other site 110662001246 intrachain domain interface; other site 110662001247 interchain domain interface [polypeptide binding]; other site 110662001248 heme bH binding site [chemical binding]; other site 110662001249 heme bL binding site [chemical binding]; other site 110662001250 Qo binding site; other site 110662001251 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 110662001252 interchain domain interface [polypeptide binding]; other site 110662001253 intrachain domain interface; other site 110662001254 Qi binding site; other site 110662001255 Qo binding site; other site 110662001256 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 110662001257 Nepovirus coat protein, central domain; Region: Nepo_coat; pfam03391 110662001258 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 110662001259 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 110662001260 active site 110662001261 motif I; other site 110662001262 motif II; other site 110662001263 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 110662001264 intersubunit interface [polypeptide binding]; other site 110662001265 active site 110662001266 Zn2+ binding site [ion binding]; other site 110662001267 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 110662001268 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 110662001269 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 110662001270 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 110662001271 DNA binding site [nucleotide binding] 110662001272 catalytic residue [active] 110662001273 H2TH interface [polypeptide binding]; other site 110662001274 putative catalytic residues [active] 110662001275 turnover-facilitating residue; other site 110662001276 intercalation triad [nucleotide binding]; other site 110662001277 8OG recognition residue [nucleotide binding]; other site 110662001278 putative reading head residues; other site 110662001279 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 110662001280 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 110662001281 Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585 110662001282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662001283 ATP binding site [chemical binding]; other site 110662001284 putative Mg++ binding site [ion binding]; other site 110662001285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662001286 nucleotide binding region [chemical binding]; other site 110662001287 ATP-binding site [chemical binding]; other site 110662001288 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 110662001289 putative peptidoglycan binding site; other site 110662001290 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 110662001291 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 110662001292 putative peptidoglycan binding site; other site 110662001293 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 110662001294 putative peptidoglycan binding site; other site 110662001295 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 110662001296 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 110662001297 NAD(P) binding site [chemical binding]; other site 110662001298 catalytic residues [active] 110662001299 trehalose synthase; Region: treS_nterm; TIGR02456 110662001300 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 110662001301 active site 110662001302 catalytic site [active] 110662001303 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 110662001304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001305 glycerol kinase; Region: glycerol_kin; TIGR01311 110662001306 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 110662001307 N- and C-terminal domain interface [polypeptide binding]; other site 110662001308 active site 110662001309 MgATP binding site [chemical binding]; other site 110662001310 catalytic site [active] 110662001311 metal binding site [ion binding]; metal-binding site 110662001312 glycerol binding site [chemical binding]; other site 110662001313 homotetramer interface [polypeptide binding]; other site 110662001314 homodimer interface [polypeptide binding]; other site 110662001315 FBP binding site [chemical binding]; other site 110662001316 protein IIAGlc interface [polypeptide binding]; other site 110662001317 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 110662001318 active site 110662001319 homodimer interface [polypeptide binding]; other site 110662001320 catalytic site [active] 110662001321 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 110662001322 active site 110662001323 trimer interface [polypeptide binding]; other site 110662001324 dimer interface [polypeptide binding]; other site 110662001325 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 110662001326 active site 110662001327 dinuclear metal binding site [ion binding]; other site 110662001328 dimerization interface [polypeptide binding]; other site 110662001329 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 110662001330 Permease family; Region: Xan_ur_permease; cl00967 110662001331 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 110662001332 chaperone protein DnaJ; Provisional; Region: PRK14299 110662001333 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 110662001334 HSP70 interaction site [polypeptide binding]; other site 110662001335 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 110662001336 substrate binding site [polypeptide binding]; other site 110662001337 dimer interface [polypeptide binding]; other site 110662001338 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 110662001339 dimer interface [polypeptide binding]; other site 110662001340 active site 110662001341 aspartate-rich active site metal binding site; other site 110662001342 allosteric magnesium binding site [ion binding]; other site 110662001343 Schiff base residues; other site 110662001344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 110662001345 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 110662001346 active site 110662001347 metal binding site [ion binding]; metal-binding site 110662001348 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 110662001349 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001350 Walker A/P-loop; other site 110662001351 ATP binding site [chemical binding]; other site 110662001352 Q-loop/lid; other site 110662001353 ABC transporter signature motif; other site 110662001354 Walker B; other site 110662001355 D-loop; other site 110662001356 H-loop/switch region; other site 110662001357 Smr domain; Region: Smr; cl02619 110662001358 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 110662001359 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 110662001360 Walker A/P-loop; other site 110662001361 ATP binding site [chemical binding]; other site 110662001362 Q-loop/lid; other site 110662001363 ABC transporter signature motif; other site 110662001364 Walker B; other site 110662001365 D-loop; other site 110662001366 H-loop/switch region; other site 110662001367 TOBE domain; Region: TOBE_2; cl01440 110662001368 GTPase CgtA; Reviewed; Region: obgE; PRK12299 110662001369 GTP1/OBG; Region: GTP1_OBG; pfam01018 110662001370 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 110662001371 G1 box; other site 110662001372 GTP/Mg2+ binding site [chemical binding]; other site 110662001373 Switch I region; other site 110662001374 G2 box; other site 110662001375 G3 box; other site 110662001376 Switch II region; other site 110662001377 G4 box; other site 110662001378 G5 box; other site 110662001379 CP12 domain; Region: CP12; cl14670 110662001380 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 110662001381 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001382 Walker A/P-loop; other site 110662001383 ATP binding site [chemical binding]; other site 110662001384 Q-loop/lid; other site 110662001385 ABC transporter signature motif; other site 110662001386 Walker B; other site 110662001387 D-loop; other site 110662001388 H-loop/switch region; other site 110662001389 ABC transporter; Region: ABC_tran_2; pfam12848 110662001390 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 110662001391 Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241 110662001392 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 110662001393 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 110662001394 putative dimer interface [polypeptide binding]; other site 110662001395 N-terminal domain interface [polypeptide binding]; other site 110662001396 putative substrate binding pocket (H-site) [chemical binding]; other site 110662001397 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 110662001398 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 110662001399 active site 110662001400 Zn binding site [ion binding]; other site 110662001401 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 110662001402 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 110662001403 protein I interface; other site 110662001404 D2 interface; other site 110662001405 protein T interface; other site 110662001406 chlorophyll binding site; other site 110662001407 beta carotene binding site; other site 110662001408 pheophytin binding site; other site 110662001409 manganese-stabilizing polypeptide interface; other site 110662001410 CP43 interface; other site 110662001411 protein L interface; other site 110662001412 oxygen evolving complex binding site; other site 110662001413 bromide binding site; other site 110662001414 quinone binding site; other site 110662001415 Fe binding site [ion binding]; other site 110662001416 core light harvesting interface; other site 110662001417 cytochrome b559 alpha subunit interface; other site 110662001418 cytochrome c-550 interface; other site 110662001419 protein J interface; other site 110662001420 acetolactate synthase; Reviewed; Region: PRK08617 110662001421 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 110662001422 PYR/PP interface [polypeptide binding]; other site 110662001423 dimer interface [polypeptide binding]; other site 110662001424 TPP binding site [chemical binding]; other site 110662001425 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 110662001426 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 110662001427 TPP-binding site [chemical binding]; other site 110662001428 dimer interface [polypeptide binding]; other site 110662001429 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 110662001430 Domain of unknown function (DUF389); Region: DUF389; cl00781 110662001431 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 110662001432 Cupin domain; Region: Cupin_2; cl09118 110662001433 Protein of unknown function (DUF3288); Region: DUF3288; pfam11691 110662001434 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 110662001435 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 110662001436 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 110662001437 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 110662001438 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 110662001439 maleylacetoacetate isomerase; Region: maiA; TIGR01262 110662001440 C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191 110662001441 dimer interface [polypeptide binding]; other site 110662001442 N-terminal domain interface [polypeptide binding]; other site 110662001443 maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site 110662001444 GAF domain; Region: GAF; cl00853 110662001445 sulfotransferase; Region: PLN02164 110662001446 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 110662001447 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 110662001448 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 110662001449 Hef nuclease; Provisional; Region: PRK13766 110662001450 Phage integrase family; Region: Phage_integrase; pfam00589 110662001451 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662001452 DNA binding site [nucleotide binding] 110662001453 Int/Topo IB signature motif; other site 110662001454 active site 110662001455 catalytic residues [active] 110662001456 D5 N terminal like; Region: D5_N; cl07360 110662001457 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 110662001458 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 110662001459 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662001460 DNA binding site [nucleotide binding] 110662001461 Int/Topo IB signature motif; other site 110662001462 active site 110662001463 catalytic residues [active] 110662001464 Helix-turn-helix domains; Region: HTH; cl00088 110662001465 Predicted methyltransferases [General function prediction only]; Region: COG0313 110662001466 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 110662001467 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638 110662001468 active site 110662001469 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 110662001470 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 110662001471 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 110662001472 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 110662001473 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 110662001474 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 110662001475 putative nucleic acid binding region [nucleotide binding]; other site 110662001476 G-X-X-G motif; other site 110662001477 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 110662001478 RNA binding site [nucleotide binding]; other site 110662001479 domain interface; other site 110662001480 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 110662001481 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 110662001482 active site 110662001483 RIP metalloprotease RseP; Region: TIGR00054 110662001484 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 110662001485 putative substrate binding region [chemical binding]; other site 110662001486 seryl-tRNA synthetase; Provisional; Region: PRK05431 110662001487 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 110662001488 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 110662001489 dimer interface [polypeptide binding]; other site 110662001490 active site 110662001491 motif 1; other site 110662001492 motif 2; other site 110662001493 motif 3; other site 110662001494 Ycf46; Provisional; Region: ycf46; CHL00195 110662001495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662001496 ATP binding site [chemical binding]; other site 110662001497 Walker A motif; other site 110662001498 Walker B motif; other site 110662001499 arginine finger; other site 110662001500 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 110662001501 putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654 110662001502 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 110662001503 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 110662001504 Bacterial PH domain; Region: DUF304; cl01348 110662001505 Ribonuclease P; Region: Ribonuclease_P; cl00457 110662001506 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 110662001507 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 110662001508 homotrimer interaction site [polypeptide binding]; other site 110662001509 active site 110662001510 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 110662001511 tandem repeat interface [polypeptide binding]; other site 110662001512 oligomer interface [polypeptide binding]; other site 110662001513 active site residues [active] 110662001514 EamA-like transporter family; Region: EamA; cl01037 110662001515 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662001516 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 110662001517 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 110662001518 Protein of unknown function (DUF721); Region: DUF721; cl02324 110662001519 PspA/IM30 family; Region: PspA_IM30; pfam04012 110662001520 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 110662001521 catalytic residues [active] 110662001522 succinyldiaminopimelate transaminase; Validated; Region: PRK07366 110662001523 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 110662001524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662001525 homodimer interface [polypeptide binding]; other site 110662001526 catalytic residue [active] 110662001527 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 110662001528 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 110662001529 Peptidase family M23; Region: Peptidase_M23; pfam01551 110662001530 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662001531 DNA binding site [nucleotide binding] 110662001532 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662001533 active site 110662001534 phosphorylation site [posttranslational modification] 110662001535 intermolecular recognition site; other site 110662001536 dimerization interface [polypeptide binding]; other site 110662001537 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 110662001538 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 110662001539 Walker A/P-loop; other site 110662001540 ATP binding site [chemical binding]; other site 110662001541 Q-loop/lid; other site 110662001542 ABC transporter signature motif; other site 110662001543 Walker B; other site 110662001544 D-loop; other site 110662001545 H-loop/switch region; other site 110662001546 NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504 110662001547 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 110662001548 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 110662001549 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 110662001550 active site 110662001551 interdomain interaction site; other site 110662001552 putative metal-binding site [ion binding]; other site 110662001553 nucleotide binding site [chemical binding]; other site 110662001554 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 110662001555 domain I; other site 110662001556 phosphate binding site [ion binding]; other site 110662001557 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 110662001558 domain II; other site 110662001559 domain III; other site 110662001560 nucleotide binding site [chemical binding]; other site 110662001561 DNA binding groove [nucleotide binding] 110662001562 catalytic site [active] 110662001563 domain IV; other site 110662001564 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435 110662001565 active site pocket [active] 110662001566 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 110662001567 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 110662001568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 110662001569 active site 110662001570 catalytic tetrad [active] 110662001571 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 110662001572 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 110662001573 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 110662001574 Lumazine binding domain; Region: Lum_binding; pfam00677 110662001575 Lumazine binding domain; Region: Lum_binding; pfam00677 110662001576 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 110662001577 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 110662001578 Subunit I/III interface [polypeptide binding]; other site 110662001579 cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007 110662001580 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 110662001581 D-pathway; other site 110662001582 Low-spin heme binding site [chemical binding]; other site 110662001583 Putative water exit pathway; other site 110662001584 Binuclear center (active site) [active] 110662001585 K-pathway; other site 110662001586 Putative proton exit pathway; other site 110662001587 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 110662001588 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 110662001589 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 110662001590 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 110662001591 UbiA prenyltransferase family; Region: UbiA; cl00337 110662001592 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001593 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 110662001594 Walker A/P-loop; other site 110662001595 ATP binding site [chemical binding]; other site 110662001596 Q-loop/lid; other site 110662001597 ABC transporter signature motif; other site 110662001598 Walker B; other site 110662001599 D-loop; other site 110662001600 H-loop/switch region; other site 110662001601 ABC-2 type transporter; Region: ABC2_membrane; cl11417 110662001602 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 110662001603 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 110662001604 putative active site cavity [active] 110662001605 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 110662001606 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 110662001607 ring oligomerisation interface [polypeptide binding]; other site 110662001608 ATP/Mg binding site [chemical binding]; other site 110662001609 stacking interactions; other site 110662001610 hinge regions; other site 110662001611 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 110662001612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001613 NAD(P) binding site [chemical binding]; other site 110662001614 active site 110662001615 Ion channel; Region: Ion_trans_2; cl11596 110662001616 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 110662001617 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001618 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 110662001619 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 110662001620 substrate binding site; other site 110662001621 dimer interface; other site 110662001622 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 110662001623 dimer interface [polypeptide binding]; other site 110662001624 catalytic triad [active] 110662001625 UbiA prenyltransferase family; Region: UbiA; cl00337 110662001626 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 110662001627 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 110662001628 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 110662001629 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 110662001630 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 110662001631 cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474 110662001632 Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802 110662001633 Iron-sulfur protein (ISP) component of the b6f complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The cytochrome b6f complex from Mastigocladus laminosus, a thermophilic cyanobacterium; Region: Rieske_cytochrome_b6f; cd03471 110662001634 cytochrome b subunit interaction site [polypeptide binding]; other site 110662001635 [2Fe-2S] cluster binding site [ion binding]; other site 110662001636 Protein of unknown function (DUF3067); Region: DUF3067; pfam11267 110662001637 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 110662001638 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 110662001639 Domain of unknown function (DUF814); Region: DUF814; pfam05670 110662001640 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 110662001641 catalytic site [active] 110662001642 G-X2-G-X-G-K; other site 110662001643 Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320 110662001644 Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627 110662001645 UGMP family protein; Validated; Region: PRK09604 110662001646 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 110662001647 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 110662001648 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 110662001649 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001650 Walker A motif; other site 110662001651 ATP binding site [chemical binding]; other site 110662001652 Walker B motif; other site 110662001653 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 110662001654 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 110662001655 active site 110662001656 homodimer interface [polypeptide binding]; other site 110662001657 Protein of unknown function (DUF1643); Region: DUF1643; cl01787 110662001658 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 110662001659 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 110662001660 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 110662001661 HIGH motif; other site 110662001662 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 110662001663 active site 110662001664 KMSKS motif; other site 110662001665 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 110662001666 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 110662001667 active site 110662001668 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001669 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 110662001670 DRTGG domain; Region: DRTGG; cl12147 110662001671 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 110662001672 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 110662001673 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 110662001674 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 110662001675 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662001676 MAPEG family; Region: MAPEG; cl09190 110662001677 Protein of unknown function (DUF520); Region: DUF520; cl00723 110662001678 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662001679 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 110662001680 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl01450 110662001681 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 110662001682 active site 110662001683 catalytic motif [active] 110662001684 Zn binding site [ion binding]; other site 110662001685 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 110662001686 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 110662001687 inhibitor-cofactor binding pocket; inhibition site 110662001688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662001689 catalytic residue [active] 110662001690 FAD binding domain; Region: FAD_binding_4; pfam01565 110662001691 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 110662001692 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 110662001693 putative phosphate binding site [ion binding]; other site 110662001694 putative catalytic site [active] 110662001695 active site 110662001696 metal binding site A [ion binding]; metal-binding site 110662001697 DNA binding site [nucleotide binding] 110662001698 putative AP binding site [nucleotide binding]; other site 110662001699 putative metal binding site B [ion binding]; other site 110662001700 Protein of unknown function DUF111; Region: DUF111; cl03398 110662001701 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 110662001702 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 110662001703 active site 110662001704 metal binding site [ion binding]; metal-binding site 110662001705 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 110662001706 active site 110662001707 metal binding site [ion binding]; metal-binding site 110662001708 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 110662001709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 110662001710 dimer interface [polypeptide binding]; other site 110662001711 conserved gate region; other site 110662001712 putative PBP binding loops; other site 110662001713 ABC-ATPase subunit interface; other site 110662001714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662001715 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 110662001716 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001717 Walker A/P-loop; other site 110662001718 ATP binding site [chemical binding]; other site 110662001719 Q-loop/lid; other site 110662001720 ABC transporter signature motif; other site 110662001721 Walker B; other site 110662001722 D-loop; other site 110662001723 H-loop/switch region; other site 110662001724 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001725 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 110662001726 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 110662001727 aromatic arch; other site 110662001728 DCoH dimer interaction site [polypeptide binding]; other site 110662001729 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 110662001730 DCoH tetramer interaction site [polypeptide binding]; other site 110662001731 substrate binding site [chemical binding]; other site 110662001732 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 110662001733 Protein of unknown function, DUF393; Region: DUF393; cl01136 110662001734 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 110662001735 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 110662001736 active site 110662001737 Zn binding site [ion binding]; other site 110662001738 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 110662001739 dimer interface [polypeptide binding]; other site 110662001740 substrate binding site [chemical binding]; other site 110662001741 metal binding sites [ion binding]; metal-binding site 110662001742 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 110662001743 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 110662001744 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 110662001745 domain interfaces; other site 110662001746 active site 110662001747 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 110662001748 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 110662001749 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662001750 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 110662001751 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 110662001752 DNA binding residues [nucleotide binding] 110662001753 primosome assembly protein PriA; Validated; Region: PRK05580 110662001754 primosome assembly protein PriA; Validated; Region: PRK05580 110662001755 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662001756 ATP binding site [chemical binding]; other site 110662001757 putative Mg++ binding site [ion binding]; other site 110662001758 Protein of unknown function (DUF3153); Region: DUF3153; pfam11353 110662001759 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 110662001760 feedback inhibition sensing region; other site 110662001761 homohexameric interface [polypeptide binding]; other site 110662001762 nucleotide binding site [chemical binding]; other site 110662001763 N-acetyl-L-glutamate binding site [chemical binding]; other site 110662001764 Protein of unknown function (DUF2854); Region: DUF2854; pfam11016 110662001765 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 110662001766 dimer interface [polypeptide binding]; other site 110662001767 ssDNA binding site [nucleotide binding]; other site 110662001768 tetramer (dimer of dimers) interface [polypeptide binding]; other site 110662001769 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922 110662001770 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 110662001771 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 110662001772 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168 110662001773 substrate binding site [chemical binding]; other site 110662001774 ATP binding site [chemical binding]; other site 110662001775 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 110662001776 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 110662001777 GDP-binding site [chemical binding]; other site 110662001778 ACT binding site; other site 110662001779 IMP binding site; other site 110662001780 photosystem II protein Psb27; Provisional; Region: PLN00064; cl11841 110662001781 prolyl-tRNA synthetase; Provisional; Region: PRK09194 110662001782 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 110662001783 dimer interface [polypeptide binding]; other site 110662001784 motif 1; other site 110662001785 active site 110662001786 motif 2; other site 110662001787 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 110662001788 putative deacylase active site [active] 110662001789 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 110662001790 active site 110662001791 motif 3; other site 110662001792 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 110662001793 anticodon binding site; other site 110662001794 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 110662001795 dimer interface [polypeptide binding]; other site 110662001796 substrate binding site [chemical binding]; other site 110662001797 metal binding sites [ion binding]; metal-binding site 110662001798 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 110662001799 catalytic loop [active] 110662001800 iron binding site [ion binding]; other site 110662001801 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 110662001802 ArsC family; Region: ArsC; pfam03960 110662001803 putative ArsC-like catalytic residues; other site 110662001804 putative TRX-like catalytic residues [active] 110662001805 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 110662001806 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 110662001807 Catalytic site [active] 110662001808 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 110662001809 dihydroorotase, multifunctional complex type; Region: pyrC_multi; TIGR00857 110662001810 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 110662001811 active site 110662001812 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 110662001813 catalytic core [active] 110662001814 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 110662001815 catalytic core [active] 110662001816 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 110662001817 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 110662001818 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 110662001819 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 110662001820 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 110662001821 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 110662001822 active site 110662001823 dimer interface [polypeptide binding]; other site 110662001824 catalytic residue [active] 110662001825 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 110662001826 ligand binding site [chemical binding]; other site 110662001827 flexible hinge region; other site 110662001828 PUCC protein; Region: PUCC; pfam03209 110662001829 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 110662001830 DNA photolyase; Region: DNA_photolyase; pfam00875 110662001831 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 110662001832 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 110662001833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001834 ribosome recycling factor; Reviewed; Region: frr; PRK00083 110662001835 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 110662001836 hinge region; other site 110662001837 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 110662001838 putative nucleotide binding site [chemical binding]; other site 110662001839 uridine monophosphate binding site [chemical binding]; other site 110662001840 homohexameric interface [polypeptide binding]; other site 110662001841 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 110662001842 homodimer interface [polypeptide binding]; other site 110662001843 Walker A motif; other site 110662001844 ATP binding site [chemical binding]; other site 110662001845 hydroxycobalamin binding site [chemical binding]; other site 110662001846 Walker B motif; other site 110662001847 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662001848 S-adenosylmethionine binding site [chemical binding]; other site 110662001849 Phage integrase family; Region: Phage_integrase; pfam00589 110662001850 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662001851 DNA binding site [nucleotide binding] 110662001852 Int/Topo IB signature motif; other site 110662001853 active site 110662001854 catalytic residues [active] 110662001855 ferrochelatase; Reviewed; Region: hemH; PRK00035 110662001856 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 110662001857 C-terminal domain interface [polypeptide binding]; other site 110662001858 active site 110662001859 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 110662001860 active site 110662001861 N-terminal domain interface [polypeptide binding]; other site 110662001862 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418 110662001863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 110662001864 PYR/PP interface [polypeptide binding]; other site 110662001865 dimer interface [polypeptide binding]; other site 110662001866 TPP binding site [chemical binding]; other site 110662001867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 110662001868 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 110662001869 TPP-binding site [chemical binding]; other site 110662001870 dimer interface [polypeptide binding]; other site 110662001871 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 110662001872 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001874 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 110662001875 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 110662001876 Protein of unknown function (DUF1092); Region: DUF1092; pfam06485 110662001877 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 110662001878 RNA binding site [nucleotide binding]; other site 110662001879 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 110662001880 RNA binding site [nucleotide binding]; other site 110662001881 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 110662001882 RNA binding site [nucleotide binding]; other site 110662001883 Creatinine amidohydrolase; Region: Creatininase; cl00618 110662001884 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 110662001885 dinuclear metal binding motif [ion binding]; other site 110662001886 acyl-ACP reductase; Provisional; Region: PRK14982 110662001887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001888 NAD(P) binding pocket [chemical binding]; other site 110662001889 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 110662001890 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 110662001891 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK13394 110662001892 classical (c) SDRs; Region: SDR_c; cd05233 110662001893 NAD(P) binding site [chemical binding]; other site 110662001894 active site 110662001895 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 110662001896 GTP cyclohydrolase I; Provisional; Region: PLN03044 110662001897 active site 110662001898 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 110662001899 active site 110662001900 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 110662001901 active site 110662001902 putative substrate binding region [chemical binding]; other site 110662001903 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 110662001904 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 110662001905 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 110662001906 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 110662001907 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001908 short chain dehydrogenase; Provisional; Region: PRK06197 110662001909 NAD(P) binding site [chemical binding]; other site 110662001910 active site 110662001911 protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185 110662001912 This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032 110662001913 P-loop; other site 110662001914 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 110662001915 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662001916 light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910 110662001917 Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981 110662001918 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 110662001919 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 110662001920 light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279 110662001921 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051 110662001922 putative hexamer interface [polypeptide binding]; other site 110662001923 putative hexagonal pore; other site 110662001924 Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052 110662001925 putative hexamer interface [polypeptide binding]; other site 110662001926 putative hexagonal pore; other site 110662001927 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 110662001928 active site 110662001929 dimerization interface [polypeptide binding]; other site 110662001930 Carboxysome Shell 1 (CsoS1); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CsoS1; cd07058 110662001931 Hexamer interface [polypeptide binding]; other site 110662001932 Hexagonal pore residue; other site 110662001933 Hexagonal pore; other site 110662001934 ribulose bisophosphate carboxylase; Reviewed; Region: rbcL; PRK04208 110662001935 Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232 110662001936 dimer interface [polypeptide binding]; other site 110662001937 catalytic residue [active] 110662001938 metal binding site [ion binding]; metal-binding site 110662001939 Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527 110662001940 multimerization interface [polypeptide binding]; other site 110662001941 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 110662001942 Carboxysome shell peptide mid-region; Region: CsoS2_M; pfam12288 110662001943 Carboxysome Shell Carbonic Anhydrase; Region: CsoSCA; cl07510 110662001944 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 110662001945 Hexamer/Pentamer interface [polypeptide binding]; other site 110662001946 central pore; other site 110662001947 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 110662001948 Hexamer/Pentamer interface [polypeptide binding]; other site 110662001949 central pore; other site 110662001950 Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982 110662001951 Hexamer interface [polypeptide binding]; other site 110662001952 Hexagonal pore residue; other site 110662001953 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390 110662001954 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 110662001955 NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473 110662001956 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 110662001957 CO2 hydration protein (ChpXY); Region: ChpXY; cl10905 110662001958 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 110662001959 aromatic arch; other site 110662001960 DCoH dimer interaction site [polypeptide binding]; other site 110662001961 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 110662001962 DCoH tetramer interaction site [polypeptide binding]; other site 110662001963 substrate binding site [chemical binding]; other site 110662001964 probable Rubsico expression protein CbbX; Region: cbbX_cfxQ; TIGR02880 110662001965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662001966 Walker A motif; other site 110662001967 ATP binding site [chemical binding]; other site 110662001968 Walker B motif; other site 110662001969 arginine finger; other site 110662001970 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 110662001971 dimer interface [polypeptide binding]; other site 110662001972 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 110662001973 cobyric acid synthase; Provisional; Region: PRK00784 110662001974 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662001975 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 110662001976 catalytic triad [active] 110662001977 Maf-like protein; Region: Maf; pfam02545 110662001978 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 110662001979 active site 110662001980 dimer interface [polypeptide binding]; other site 110662001981 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 110662001982 Erv1 / Alr family; Region: Evr1_Alr; cl02107 110662001983 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 110662001984 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 110662001985 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 110662001986 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 110662001987 P-loop; other site 110662001988 Magnesium ion binding site [ion binding]; other site 110662001989 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 110662001990 Catalytic site; other site 110662001991 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 110662001992 T3/T7-like RNA polymerase; Region: PHA00452 110662001993 DNA-dependent RNA polymerase; Region: RNA_pol; pfam00940 110662001994 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662001995 DNA binding site [nucleotide binding] 110662001996 Int/Topo IB signature motif; other site 110662001997 active site 110662001998 catalytic residues [active] 110662001999 ribosomal protein S4; Reviewed; Region: rps4; CHL00113 110662002000 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 110662002001 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 110662002002 RNA binding surface [nucleotide binding]; other site 110662002003 Domain of unknown function DUF37; Region: DUF37; cl00506 110662002004 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 110662002005 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 110662002006 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 110662002007 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 110662002008 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 110662002009 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 110662002010 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662002011 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662002012 catalytic residue [active] 110662002013 GAF domain; Region: GAF; cl00853 110662002014 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 110662002015 Protein of unknown function (DUF4079); Region: DUF4079; pfam13301 110662002016 cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030 110662002017 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 110662002018 DXD motif; other site 110662002019 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 110662002020 dimerization interface [polypeptide binding]; other site 110662002021 putative catalytic residue [active] 110662002022 NifU-like domain; Region: NifU; cl00484 110662002023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002024 Predicted dehydrogenase [General function prediction only]; Region: COG0579 110662002025 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 110662002026 GTP-binding protein LepA; Provisional; Region: PRK05433 110662002027 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 110662002028 G1 box; other site 110662002029 putative GEF interaction site [polypeptide binding]; other site 110662002030 GTP/Mg2+ binding site [chemical binding]; other site 110662002031 Switch I region; other site 110662002032 G2 box; other site 110662002033 G3 box; other site 110662002034 Switch II region; other site 110662002035 G4 box; other site 110662002036 G5 box; other site 110662002037 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 110662002038 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 110662002039 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 110662002040 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 110662002041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662002042 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 110662002043 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 110662002044 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 110662002045 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 110662002046 DNA binding site [nucleotide binding] 110662002047 active site 110662002048 16S rRNA methyltransferase B; Provisional; Region: PRK14901 110662002049 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 110662002050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662002051 Transglycosylase; Region: Transgly; cl07896 110662002052 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 110662002053 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 110662002054 UbiA prenyltransferase family; Region: UbiA; cl00337 110662002055 Protein of unknown function (DUF2862); Region: DUF2862; pfam11061 110662002056 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 110662002057 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 110662002058 substrate binding site [chemical binding]; other site 110662002059 glutamase interaction surface [polypeptide binding]; other site 110662002060 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 110662002061 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662002062 S-adenosylmethionine binding site [chemical binding]; other site 110662002063 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662002064 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 110662002065 dimer interface [polypeptide binding]; other site 110662002066 motif 1; other site 110662002067 active site 110662002068 motif 2; other site 110662002069 motif 3; other site 110662002070 Competence protein; Region: Competence; cl00471 110662002071 AAA domain; Region: AAA_18; pfam13238 110662002072 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 110662002073 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 110662002074 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 110662002075 active site 110662002076 catalytic site [active] 110662002077 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 110662002078 N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942 110662002079 dimerization interface [polypeptide binding]; other site 110662002080 putative active cleft [active] 110662002081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 110662002082 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662002083 binding surface 110662002084 TPR motif; other site 110662002085 conserved hypothetical protein; Region: TIGR02466 110662002086 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 110662002087 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 110662002088 potential catalytic triad [active] 110662002089 conserved cys residue [active] 110662002090 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 110662002091 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 110662002092 PYR/PP interface [polypeptide binding]; other site 110662002093 dimer interface [polypeptide binding]; other site 110662002094 TPP binding site [chemical binding]; other site 110662002095 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 110662002096 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 110662002097 TPP-binding site [chemical binding]; other site 110662002098 dimer interface [polypeptide binding]; other site 110662002099 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 110662002100 NmrA-like family; Region: NmrA; pfam05368 110662002101 NADP binding site [chemical binding]; other site 110662002102 active site 110662002103 regulatory binding site [polypeptide binding]; other site 110662002104 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 110662002105 EthD protein; Region: EthD; cl06234 110662002106 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 110662002107 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 110662002108 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 110662002109 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 110662002110 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 110662002111 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 110662002112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002113 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 110662002114 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 110662002115 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 110662002116 potential catalytic triad [active] 110662002117 conserved cys residue [active] 110662002118 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662002119 proline-specific peptidases, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 110662002120 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394 110662002121 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 110662002122 active site 110662002123 metal binding site [ion binding]; metal-binding site 110662002124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 110662002125 S-layer homology domain; Region: SLH; pfam00395 110662002126 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 110662002127 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 110662002128 putative ADP-binding pocket [chemical binding]; other site 110662002129 Bacterial sugar transferase; Region: Bac_transf; cl00939 110662002130 CobD/Cbib protein; Region: CobD_Cbib; cl00561 110662002131 ketol-acid reductoisomerase; Provisional; Region: PRK05479 110662002132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002133 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 110662002134 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 110662002135 oligomer interface [polypeptide binding]; other site 110662002136 active site residues [active] 110662002137 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 110662002138 oligomer interface [polypeptide binding]; other site 110662002139 active site residues [active] 110662002140 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 110662002141 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 110662002142 putative active site [active] 110662002143 coproporphyrinogen III oxidase; Provisional; Region: PRK07379 110662002144 HemN C-terminal region; Region: HemN_C; pfam06969 110662002145 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 110662002146 oligomerization interface [polypeptide binding]; other site 110662002147 active site 110662002148 metal binding site [ion binding]; metal-binding site 110662002149 cell division protein FtsZ; Validated; Region: PRK09330 110662002150 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 110662002151 nucleotide binding site [chemical binding]; other site 110662002152 SulA interaction site; other site 110662002153 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 110662002154 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 110662002155 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 110662002156 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662002157 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333 110662002158 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 110662002159 TRAM domain; Region: TRAM; cl01282 110662002160 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 110662002161 active site 110662002162 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 110662002163 Domain of unknown function (DUF4359); Region: DUF4359; pfam14271 110662002164 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 110662002165 active site 110662002166 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 110662002167 FAD binding domain; Region: FAD_binding_4; pfam01565 110662002168 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662002169 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662002170 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662002171 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 110662002172 acetylornithine aminotransferase; Provisional; Region: PRK02627 110662002173 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 110662002174 inhibitor-cofactor binding pocket; inhibition site 110662002175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662002176 catalytic residue [active] 110662002177 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 110662002178 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 110662002179 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662002180 DNA binding site [nucleotide binding] 110662002181 Int/Topo IB signature motif; other site 110662002182 active site 110662002183 catalytic residues [active] 110662002184 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 110662002185 hinge; other site 110662002186 active site 110662002187 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 110662002188 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 110662002189 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 110662002190 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002192 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 110662002193 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 110662002194 active site 110662002195 ribulose/triose binding site [chemical binding]; other site 110662002196 phosphate binding site [ion binding]; other site 110662002197 substrate (anthranilate) binding pocket [chemical binding]; other site 110662002198 product (indole) binding pocket [chemical binding]; other site 110662002199 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 110662002200 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 110662002201 Catalytic site [active] 110662002202 Nickel-containing superoxide dismutase; Region: Sod_Ni; cl07609 110662002203 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 110662002204 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 110662002205 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 110662002206 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 110662002207 putative active site [active] 110662002208 catalytic triad [active] 110662002209 putative dimer interface [polypeptide binding]; other site 110662002210 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 110662002211 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 110662002212 Ligand Binding Site [chemical binding]; other site 110662002213 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 110662002214 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 110662002215 putative substrate binding site [chemical binding]; other site 110662002216 putative ATP binding site [chemical binding]; other site 110662002217 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 110662002218 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 110662002219 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662002220 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 110662002221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 110662002222 DNA binding residues [nucleotide binding] 110662002223 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 110662002224 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 110662002225 tetramer interface [polypeptide binding]; other site 110662002226 TPP-binding site [chemical binding]; other site 110662002227 heterodimer interface [polypeptide binding]; other site 110662002228 phosphorylation loop region [posttranslational modification] 110662002229 Protein of unknown function (DUF4101); Region: DUF4101; pfam13355 110662002230 signal recognition particle protein; Provisional; Region: PRK10867 110662002231 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 110662002232 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 110662002233 P loop; other site 110662002234 GTP binding site [chemical binding]; other site 110662002235 Signal peptide binding domain; Region: SRP_SPB; pfam02978 110662002236 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 110662002237 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662002238 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 110662002239 GTPase Era; Reviewed; Region: era; PRK00089 110662002240 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 110662002241 G1 box; other site 110662002242 GTP/Mg2+ binding site [chemical binding]; other site 110662002243 Switch I region; other site 110662002244 G2 box; other site 110662002245 Switch II region; other site 110662002246 G3 box; other site 110662002247 G4 box; other site 110662002248 G5 box; other site 110662002249 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 110662002250 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl02184 110662002251 CpeS-like protein; Region: CpeS; pfam09367 110662002252 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 110662002253 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 110662002254 homotrimer interaction site [polypeptide binding]; other site 110662002255 zinc binding site [ion binding]; other site 110662002256 CDP-binding sites; other site 110662002257 uncharacterized cyanobacterial protein, TIGR03792 family; Region: TIGR03792 110662002258 AIR carboxylase; Region: AIRC; cl00310 110662002259 Protein of unknown function (DUF1517); Region: DUF1517; cl01807 110662002260 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 110662002261 thiS-thiF/thiG interaction site; other site 110662002262 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 110662002263 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 110662002264 thiamine phosphate binding site [chemical binding]; other site 110662002265 active site 110662002266 pyrophosphate binding site [ion binding]; other site 110662002267 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 110662002268 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 110662002269 active site 110662002270 Riboflavin kinase; Region: Flavokinase; cl03312 110662002271 Protein of unknown function (DUF3611); Region: DUF3611; pfam12263 110662002272 Survival protein SurE; Region: SurE; cl00448 110662002273 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 110662002274 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 110662002275 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 110662002276 dimer interface [polypeptide binding]; other site 110662002277 motif 1; other site 110662002278 active site 110662002279 motif 2; other site 110662002280 motif 3; other site 110662002281 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 110662002282 Uncharacterized conserved protein [Function unknown]; Region: COG5361 110662002283 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 110662002284 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 110662002285 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 110662002286 transcriptional regulator PhoB; Provisional; Region: PRK10161 110662002287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662002288 DNA binding site [nucleotide binding] 110662002289 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 110662002290 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 110662002291 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 110662002292 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662002293 S-adenosylmethionine binding site [chemical binding]; other site 110662002294 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 110662002295 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 110662002296 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 110662002297 Protein of unknown function (DUF3122); Region: DUF3122; pfam11320 110662002298 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 110662002299 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 110662002300 catalytic motif [active] 110662002301 Zn binding site [ion binding]; other site 110662002302 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 110662002303 Ion channel; Region: Ion_trans_2; cl11596 110662002304 Uncharacterised ACR, COG2135; Region: DUF159; cl03646 110662002305 FtsH Extracellular; Region: FtsH_ext; pfam06480 110662002306 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 110662002307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662002308 Walker A motif; other site 110662002309 ATP binding site [chemical binding]; other site 110662002310 Walker B motif; other site 110662002311 arginine finger; other site 110662002312 Peptidase family M41; Region: Peptidase_M41; pfam01434 110662002313 ornithine carbamoyltransferase; Provisional; Region: PRK00779 110662002314 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 110662002315 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002316 SOS regulatory protein LexA; Region: lexA; TIGR00498 110662002317 Helix-turn-helix domains; Region: HTH; cl00088 110662002318 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 110662002319 Catalytic site [active] 110662002320 Predicted P-loop ATPase and inactivated derivatives [General function prediction only]; Region: COG5545 110662002321 Virulence-associated protein E; Region: VirE; pfam05272 110662002322 Virulence-associated protein E; Region: VirE; pfam05272 110662002323 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662002324 DNA binding site [nucleotide binding] 110662002325 Int/Topo IB signature motif; other site 110662002326 active site 110662002327 catalytic residues [active] 110662002328 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662002329 DNA binding site [nucleotide binding] 110662002330 Int/Topo IB signature motif; other site 110662002331 active site 110662002332 catalytic residues [active] 110662002333 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 110662002334 nucleotide binding site [chemical binding]; other site 110662002335 Phage integrase family; Region: Phage_integrase; pfam00589 110662002336 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662002337 DNA binding site [nucleotide binding] 110662002338 Int/Topo IB signature motif; other site 110662002339 active site 110662002340 catalytic residues [active] 110662002341 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 110662002342 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 110662002343 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 110662002344 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 110662002345 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 110662002346 homotrimer interaction site [polypeptide binding]; other site 110662002347 putative active site [active] 110662002348 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662002349 ATP phosphoribosyltransferase; Region: HisG; cl15266 110662002350 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 110662002351 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662002352 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 110662002353 Walker A/P-loop; other site 110662002354 ATP binding site [chemical binding]; other site 110662002355 Q-loop/lid; other site 110662002356 ABC transporter signature motif; other site 110662002357 Walker B; other site 110662002358 D-loop; other site 110662002359 H-loop/switch region; other site 110662002360 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 110662002361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 110662002362 Coenzyme A binding pocket [chemical binding]; other site 110662002363 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 110662002364 Probable Catalytic site; other site 110662002365 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662002366 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 110662002367 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 110662002368 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 110662002369 protein binding site [polypeptide binding]; other site 110662002370 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 110662002371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662002372 Walker A motif; other site 110662002373 ATP binding site [chemical binding]; other site 110662002374 Walker B motif; other site 110662002375 arginine finger; other site 110662002376 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 110662002377 DnaA box-binding interface [nucleotide binding]; other site 110662002378 Putative ParB-like nuclease; Region: ParBc_2; cl01772 110662002379 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 110662002380 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 110662002381 C-terminal domain interface [polypeptide binding]; other site 110662002382 GSH binding site (G-site) [chemical binding]; other site 110662002383 dimer interface [polypeptide binding]; other site 110662002384 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 110662002385 N-terminal domain interface [polypeptide binding]; other site 110662002386 glutathione reductase; Validated; Region: PRK06116 110662002387 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002388 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 110662002389 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 110662002390 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 110662002391 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 110662002392 Subunit I/III interface [polypeptide binding]; other site 110662002393 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 110662002394 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 110662002395 D-pathway; other site 110662002396 Low-spin heme binding site [chemical binding]; other site 110662002397 Putative water exit pathway; other site 110662002398 Binuclear center (active site) [active] 110662002399 K-pathway; other site 110662002400 Putative proton exit pathway; other site 110662002401 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 110662002402 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 110662002403 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 110662002404 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 110662002405 Predicted membrane protein (DUF2231); Region: DUF2231; cl01730 110662002406 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 110662002407 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 110662002408 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 110662002409 Permease family; Region: Xan_ur_permease; cl00967 110662002410 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 110662002411 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 110662002412 active site 110662002413 substrate binding pocket [chemical binding]; other site 110662002414 dimer interface [polypeptide binding]; other site 110662002415 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 110662002416 NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716 110662002417 Protein of unknown function (DUF3007); Region: DUF3007; pfam11460 110662002418 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 110662002419 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 110662002420 substrate binding site [chemical binding]; other site 110662002421 active site 110662002422 catalytic residues [active] 110662002423 heterodimer interface [polypeptide binding]; other site 110662002424 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 110662002425 YCII-related domain; Region: YCII; cl00999 110662002426 Cytochrome c; Region: Cytochrom_C; cl11414 110662002427 Protein of unknown function (DUF3136); Region: DUF3136; pfam11334 110662002428 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 110662002429 nif11 domain/cupin domain protein; Region: nif11_cupin; TIGR03890 110662002430 Cupin domain; Region: Cupin_2; cl09118 110662002431 Phosphate-starvation-inducible E; Region: PsiE; cl01264 110662002432 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 110662002433 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 110662002434 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 110662002435 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662002436 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 110662002437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 110662002438 DNA binding residues [nucleotide binding] 110662002439 Predicted membrane protein (DUF2214); Region: DUF2214; cl01427 110662002440 Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279 110662002441 active site 110662002442 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 110662002443 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 110662002444 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 110662002445 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 110662002446 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 110662002447 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 110662002448 Clp amino terminal domain; Region: Clp_N; pfam02861 110662002449 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662002450 Walker A motif; other site 110662002451 ATP binding site [chemical binding]; other site 110662002452 Walker B motif; other site 110662002453 arginine finger; other site 110662002454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662002455 Walker A motif; other site 110662002456 ATP binding site [chemical binding]; other site 110662002457 Walker B motif; other site 110662002458 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 110662002459 Cytochrome c; Region: Cytochrom_C; cl11414 110662002460 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 110662002461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002462 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 110662002463 NAD(P) binding site [chemical binding]; other site 110662002464 active site 110662002465 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 110662002466 substrate binding site [chemical binding]; other site 110662002467 active site 110662002468 glycogen branching enzyme; Provisional; Region: PRK05402 110662002469 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 110662002470 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 110662002471 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 110662002472 active site 110662002473 catalytic site [active] 110662002474 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 110662002475 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 110662002476 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 110662002477 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 110662002478 Protein of function (DUF2518); Region: DUF2518; pfam10726 110662002479 Family of unknown function (DUF490); Region: DUF490; pfam04357 110662002480 Family of unknown function (DUF490); Region: DUF490; pfam04357 110662002481 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 110662002482 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 110662002483 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 110662002484 putative catalytic cysteine [active] 110662002485 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 110662002486 active site 110662002487 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 110662002488 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 110662002489 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 110662002490 active site 110662002491 Zn binding site [ion binding]; other site 110662002492 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 110662002493 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 110662002494 homoserine kinase; Provisional; Region: PRK01212 110662002495 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 110662002496 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 110662002497 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 110662002498 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 110662002499 Domain of unknown function (DUF1824); Region: DUF1824; pfam08854 110662002500 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 110662002501 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 110662002502 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 110662002503 active site 110662002504 dimer interface [polypeptide binding]; other site 110662002505 motif 1; other site 110662002506 motif 2; other site 110662002507 motif 3; other site 110662002508 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 110662002509 anticodon binding site; other site 110662002510 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 110662002511 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 110662002512 catalytic residue [active] 110662002513 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 110662002514 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 110662002515 active site 110662002516 HIGH motif; other site 110662002517 dimer interface [polypeptide binding]; other site 110662002518 KMSKS motif; other site 110662002519 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 110662002520 Cation efflux family; Region: Cation_efflux; cl00316 110662002521 Domain of unknown function (DUF697); Region: DUF697; cl12064 110662002522 D1 subunit of photosystem II (PS II); Region: Photosystem-II_D1; cd09289 110662002523 protein I interface; other site 110662002524 D2 interface; other site 110662002525 protein T interface; other site 110662002526 chlorophyll binding site; other site 110662002527 beta carotene binding site; other site 110662002528 pheophytin binding site; other site 110662002529 manganese-stabilizing polypeptide interface; other site 110662002530 CP43 interface; other site 110662002531 protein L interface; other site 110662002532 oxygen evolving complex binding site; other site 110662002533 bromide binding site; other site 110662002534 quinone binding site; other site 110662002535 Fe binding site [ion binding]; other site 110662002536 core light harvesting interface; other site 110662002537 cytochrome b559 alpha subunit interface; other site 110662002538 cytochrome c-550 interface; other site 110662002539 protein J interface; other site 110662002540 L-seryl-tRNA(Sec) kinase, archaeal; Region: selen_PSTK; TIGR03574 110662002541 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662002542 active site 110662002543 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 110662002544 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 110662002545 CP12 domain; Region: CP12; cl14670 110662002546 DoxX; Region: DoxX; cl00976 110662002547 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 110662002548 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 110662002549 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 110662002550 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 110662002551 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 110662002552 Macrophage migration inhibitory factor (MIF); Region: MIF; pfam01187 110662002553 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 110662002554 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 110662002555 [2Fe-2S] cluster binding site [ion binding]; other site 110662002556 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 110662002557 alpha subunit interface [polypeptide binding]; other site 110662002558 active site 110662002559 substrate binding site [chemical binding]; other site 110662002560 Fe binding site [ion binding]; other site 110662002561 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 110662002562 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 110662002563 Walker A/P-loop; other site 110662002564 ATP binding site [chemical binding]; other site 110662002565 Q-loop/lid; other site 110662002566 ABC transporter signature motif; other site 110662002567 Walker B; other site 110662002568 D-loop; other site 110662002569 H-loop/switch region; other site 110662002570 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662002571 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 110662002572 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 110662002573 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662002574 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 110662002575 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; cl00418 110662002576 Arginase family; Region: Arginase; cl00306 110662002577 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 110662002578 NADP binding site [chemical binding]; other site 110662002579 homodimer interface [polypeptide binding]; other site 110662002580 active site 110662002581 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 110662002582 HSP70 interaction site [polypeptide binding]; other site 110662002583 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 110662002584 Uncharacterized conserved protein [Function unknown]; Region: COG3349 110662002585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002586 S-layer homology domain; Region: SLH; pfam00395 110662002587 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 110662002588 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 110662002589 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 110662002590 Walker A/P-loop; other site 110662002591 ATP binding site [chemical binding]; other site 110662002592 Q-loop/lid; other site 110662002593 ABC transporter signature motif; other site 110662002594 Walker B; other site 110662002595 D-loop; other site 110662002596 H-loop/switch region; other site 110662002597 Membrane transport protein; Region: Mem_trans; cl09117 110662002598 Chromate transporter; Region: Chromate_transp; pfam02417 110662002599 Chromate transporter; Region: Chromate_transp; pfam02417 110662002600 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 110662002601 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 110662002602 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002603 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002604 DsrE/DsrF-like family; Region: DrsE; cl00672 110662002605 Predicted amidohydrolase [General function prediction only]; Region: COG0388 110662002606 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 110662002607 putative active site [active] 110662002608 catalytic triad [active] 110662002609 putative dimer interface [polypeptide binding]; other site 110662002610 radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043 110662002611 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662002612 AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049 110662002613 AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192 110662002614 dimerization interface [polypeptide binding]; other site 110662002615 putative ATP binding site [chemical binding]; other site 110662002616 MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042 110662002617 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 110662002618 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 110662002619 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 110662002620 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 110662002621 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 110662002622 Protein of unknown function (DUF1254); Region: DUF1254; cl02257 110662002623 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 110662002624 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 110662002625 Protein of unknown function (DUF760); Region: DUF760; pfam05542 110662002626 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 110662002627 Catalytic site [active] 110662002628 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 110662002629 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 110662002630 dimer interface [polypeptide binding]; other site 110662002631 tetramer interface [polypeptide binding]; other site 110662002632 PYR/PP interface [polypeptide binding]; other site 110662002633 TPP binding site [chemical binding]; other site 110662002634 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 110662002635 TPP-binding site; other site 110662002636 dihydroxynaphthoic acid synthetase; Validated; Region: PRK07396 110662002637 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 110662002638 substrate binding site [chemical binding]; other site 110662002639 oxyanion hole (OAH) forming residues; other site 110662002640 trimer interface [polypeptide binding]; other site 110662002641 glycogen synthase; Provisional; Region: glgA; PRK00654 110662002642 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 110662002643 ADP-binding pocket [chemical binding]; other site 110662002644 homodimer interface [polypeptide binding]; other site 110662002645 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 110662002646 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 110662002647 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 110662002648 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360 110662002649 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 110662002650 Substrate binding site; other site 110662002651 Mg++ binding site; other site 110662002652 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 110662002653 active site 110662002654 substrate binding site [chemical binding]; other site 110662002655 CoA binding site [chemical binding]; other site 110662002656 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662002657 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 110662002658 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 110662002659 hinge; other site 110662002660 active site 110662002661 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 110662002662 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 110662002663 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 110662002664 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 110662002665 putative active site [active] 110662002666 catalytic triad [active] 110662002667 dimer interface [polypeptide binding]; other site 110662002668 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 110662002669 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 110662002670 active site 110662002671 metal binding site [ion binding]; metal-binding site 110662002672 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 110662002673 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 110662002674 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 110662002675 substrate binding pocket [chemical binding]; other site 110662002676 chain length determination region; other site 110662002677 substrate-Mg2+ binding site; other site 110662002678 catalytic residues [active] 110662002679 aspartate-rich region 1; other site 110662002680 active site lid residues [active] 110662002681 aspartate-rich region 2; other site 110662002682 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 110662002683 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 110662002684 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 110662002685 motif II; other site 110662002686 acetyl-CoA synthetase; Provisional; Region: PRK00174 110662002687 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 110662002688 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 110662002689 Protein of unknown function (DUF1350); Region: DUF1350; pfam07082 110662002690 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 110662002691 catalytic triad [active] 110662002692 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 110662002693 active site 110662002694 substrate binding site [chemical binding]; other site 110662002695 catalytic site [active] 110662002696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 110662002697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 110662002698 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 110662002699 ligand binding site [chemical binding]; other site 110662002700 flexible hinge region; other site 110662002701 Helix-turn-helix domains; Region: HTH; cl00088 110662002702 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 110662002703 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 110662002704 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662002705 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662002706 Walker A/P-loop; other site 110662002707 ATP binding site [chemical binding]; other site 110662002708 Q-loop/lid; other site 110662002709 ABC transporter signature motif; other site 110662002710 Walker B; other site 110662002711 D-loop; other site 110662002712 H-loop/switch region; other site 110662002713 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 110662002714 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 110662002715 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 110662002716 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 110662002717 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 110662002718 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 110662002719 catalytic site [active] 110662002720 subunit interface [polypeptide binding]; other site 110662002721 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 110662002722 anti sigma factor interaction site; other site 110662002723 regulatory phosphorylation site [posttranslational modification]; other site 110662002724 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 110662002725 U2 snRNP auxilliary factor, large subunit, splicing factor; Region: U2AF_lg; TIGR01642 110662002726 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 110662002727 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 110662002728 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 110662002729 Domain of unknown function (DUF1816); Region: DUF1816; pfam08846 110662002730 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 110662002731 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 110662002732 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK07374 110662002733 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 110662002734 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 110662002735 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 110662002736 generic binding surface I; other site 110662002737 generic binding surface II; other site 110662002738 Protein of unknown function (DUF3464); Region: DUF3464; pfam11947 110662002739 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 110662002740 16S/18S rRNA binding site [nucleotide binding]; other site 110662002741 S13e-L30e interaction site [polypeptide binding]; other site 110662002742 25S rRNA binding site [nucleotide binding]; other site 110662002743 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 110662002744 RuvA N terminal domain; Region: RuvA_N; pfam01330 110662002745 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 110662002746 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 110662002747 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 110662002748 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 110662002749 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 110662002750 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 110662002751 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 110662002752 Ion transport protein; Region: Ion_trans; pfam00520 110662002753 Ion channel; Region: Ion_trans_2; cl11596 110662002754 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 110662002755 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 110662002756 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 110662002757 substrate binding pocket [chemical binding]; other site 110662002758 membrane-bound complex binding site; other site 110662002759 hinge residues; other site 110662002760 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 110662002761 EamA-like transporter family; Region: EamA; cl01037 110662002762 EamA-like transporter family; Region: EamA; cl01037 110662002763 DNA primase; Validated; Region: dnaG; PRK05667 110662002764 CHC2 zinc finger; Region: zf-CHC2; cl15369 110662002765 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 110662002766 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 110662002767 active site 110662002768 metal binding site [ion binding]; metal-binding site 110662002769 interdomain interaction site; other site 110662002770 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 110662002771 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 110662002772 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 110662002773 active site 110662002774 DNA binding site [nucleotide binding] 110662002775 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 110662002776 Catalytic site [active] 110662002777 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 110662002778 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773 110662002779 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 110662002780 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662002781 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662002782 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662002783 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 110662002784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662002785 S-adenosylmethionine binding site [chemical binding]; other site 110662002786 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534 110662002787 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 110662002788 Protein of unknown function (DUF3082); Region: DUF3082; pfam11282 110662002789 pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144 110662002790 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 110662002791 alpha subunit interface [polypeptide binding]; other site 110662002792 TPP binding site [chemical binding]; other site 110662002793 heterodimer interface [polypeptide binding]; other site 110662002794 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 110662002795 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 110662002796 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 110662002797 Protein export membrane protein; Region: SecD_SecF; cl14618 110662002798 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 110662002799 protein-export membrane protein SecF; Region: 3a0501s07; TIGR00966 110662002800 Protein export membrane protein; Region: SecD_SecF; cl14618 110662002801 Domain of unknown function DUF20; Region: UPF0118; cl00465 110662002802 Domain of unknown function DUF20; Region: UPF0118; cl00465 110662002803 Psb28 protein; Region: Psb28; cl04326 110662002804 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 110662002805 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 110662002806 active site residue [active] 110662002807 GUN4-like; Region: GUN4; pfam05419 110662002808 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 110662002809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662002810 S-adenosylmethionine binding site [chemical binding]; other site 110662002811 glutamine synthetase, type I; Region: GlnA; TIGR00653 110662002812 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 110662002813 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 110662002814 Phycobilisome protein; Region: Phycobilisome; cl08227 110662002815 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 110662002816 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 110662002817 homodimer interface [polypeptide binding]; other site 110662002818 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662002819 catalytic residue [active] 110662002820 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 110662002821 nucleoside/Zn binding site; other site 110662002822 dimer interface [polypeptide binding]; other site 110662002823 catalytic motif [active] 110662002824 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662002825 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662002826 catalytic residue [active] 110662002827 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 110662002828 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 110662002829 G1 box; other site 110662002830 GTP/Mg2+ binding site [chemical binding]; other site 110662002831 Switch I region; other site 110662002832 G2 box; other site 110662002833 Switch II region; other site 110662002834 G3 box; other site 110662002835 G4 box; other site 110662002836 G5 box; other site 110662002837 Domain of unknown function (DUF697); Region: DUF697; cl12064 110662002838 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 110662002839 lipoprotein signal peptidase; Provisional; Region: PRK14787 110662002840 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 110662002841 Protein of unknown function (DUF3148); Region: DUF3148; pfam11347 110662002842 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 110662002843 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 110662002844 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 110662002845 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 110662002846 Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930 110662002847 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 110662002848 DevC protein; Region: devC; TIGR01185 110662002849 FtsX-like permease family; Region: FtsX; pfam02687 110662002850 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 110662002851 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 110662002852 Walker A/P-loop; other site 110662002853 ATP binding site [chemical binding]; other site 110662002854 Q-loop/lid; other site 110662002855 ABC transporter signature motif; other site 110662002856 Walker B; other site 110662002857 D-loop; other site 110662002858 H-loop/switch region; other site 110662002859 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 110662002860 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 110662002861 Probable Catalytic site; other site 110662002862 metal-binding site 110662002863 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 110662002864 rRNA interaction site [nucleotide binding]; other site 110662002865 S8 interaction site; other site 110662002866 putative laminin-1 binding site; other site 110662002867 elongation factor Ts; Reviewed; Region: tsf; PRK12332 110662002868 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 110662002869 Elongation factor TS; Region: EF_TS; pfam00889 110662002870 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 110662002871 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 110662002872 generic binding surface II; other site 110662002873 ssDNA binding site; other site 110662002874 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662002875 ATP binding site [chemical binding]; other site 110662002876 putative Mg++ binding site [ion binding]; other site 110662002877 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662002878 nucleotide binding region [chemical binding]; other site 110662002879 ATP-binding site [chemical binding]; other site 110662002880 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 110662002881 sulfite reductase subunit beta; Provisional; Region: PRK13504 110662002882 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 110662002883 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 110662002884 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 110662002885 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 110662002886 DNA binding site [nucleotide binding] 110662002887 Int/Topo IB signature motif; other site 110662002888 active site 110662002889 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 110662002890 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002891 geranylgeranyl reductase; Region: ChlP; TIGR02028 110662002892 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 110662002893 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 110662002894 Peptidase family U32; Region: Peptidase_U32; cl03113 110662002895 Collagenase; Region: DUF3656; pfam12392 110662002896 Peptidase family U32; Region: Peptidase_U32; cl03113 110662002897 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 110662002898 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 110662002899 G1 box; other site 110662002900 putative GEF interaction site [polypeptide binding]; other site 110662002901 GTP/Mg2+ binding site [chemical binding]; other site 110662002902 Switch I region; other site 110662002903 G2 box; other site 110662002904 G3 box; other site 110662002905 Switch II region; other site 110662002906 G4 box; other site 110662002907 G5 box; other site 110662002908 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 110662002909 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 110662002910 Domain of unknown function (DUF309); Region: DUF309; cl00667 110662002911 OstA-like protein; Region: OstA; cl00844 110662002912 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 110662002913 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 110662002914 Walker A/P-loop; other site 110662002915 ATP binding site [chemical binding]; other site 110662002916 Q-loop/lid; other site 110662002917 ABC transporter signature motif; other site 110662002918 Walker B; other site 110662002919 D-loop; other site 110662002920 H-loop/switch region; other site 110662002921 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 110662002922 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 110662002923 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 110662002924 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 110662002925 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 110662002926 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 110662002927 substrate binding site [chemical binding]; other site 110662002928 hexamer interface [polypeptide binding]; other site 110662002929 metal binding site [ion binding]; metal-binding site 110662002930 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 110662002931 putative active site [active] 110662002932 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 110662002933 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 110662002934 tRNA; other site 110662002935 putative tRNA binding site [nucleotide binding]; other site 110662002936 putative NADP binding site [chemical binding]; other site 110662002937 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 110662002938 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 110662002939 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 110662002940 ligand binding site; other site 110662002941 oligomer interface; other site 110662002942 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662002943 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 110662002944 dimer interface [polypeptide binding]; other site 110662002945 N-terminal domain interface [polypeptide binding]; other site 110662002946 sulfate 1 binding site; other site 110662002947 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002948 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 110662002949 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 110662002950 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 110662002951 putative active site [active] 110662002952 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292 110662002953 Dehydratase family; Region: ILVD_EDD; cl00340 110662002954 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 110662002955 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 110662002956 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 110662002957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662002958 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 110662002959 Domain of unknown function (DUF389); Region: DUF389; cl00781 110662002960 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662002961 short chain dehydrogenase; Provisional; Region: PRK12937 110662002962 NAD(P) binding site [chemical binding]; other site 110662002963 active site 110662002964 SdiA-regulated; Region: SdiA-regulated; cl06158 110662002965 putative active site [active] 110662002966 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 110662002967 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 110662002968 HetN oxidoreductase-like, classical (c) SDR; Region: HetN_like_SDR_c; cd08932 110662002969 putative NAD(P) binding site [chemical binding]; other site 110662002970 active site 110662002971 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 110662002972 ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent; Region: RTPR; TIGR02505 110662002973 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 110662002974 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 110662002975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662002976 S-adenosylmethionine binding site [chemical binding]; other site 110662002977 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 110662002978 RF3 subfamily. Peptide chain release factor 3 (RF3) is a protein involved in the termination step of translation in bacteria. Termination occurs when class I release factors (RF1 or RF2) recognize the stop codon at the A-site of the ribosome and...; Region: RF3; cd04169 110662002979 G1 box; other site 110662002980 putative GEF interaction site [polypeptide binding]; other site 110662002981 GTP/Mg2+ binding site [chemical binding]; other site 110662002982 Switch I region; other site 110662002983 G2 box; other site 110662002984 G3 box; other site 110662002985 Switch II region; other site 110662002986 G4 box; other site 110662002987 G5 box; other site 110662002988 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 110662002989 Protein of unknown function (DUF3353); Region: DUF3353; pfam11833 110662002990 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 110662002991 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 110662002992 dimerization interface [polypeptide binding]; other site 110662002993 domain crossover interface; other site 110662002994 redox-dependent activation switch; other site 110662002995 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 110662002996 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 110662002997 Walker A/P-loop; other site 110662002998 ATP binding site [chemical binding]; other site 110662002999 Q-loop/lid; other site 110662003000 ABC transporter signature motif; other site 110662003001 Walker B; other site 110662003002 D-loop; other site 110662003003 H-loop/switch region; other site 110662003004 Protein of unknown function (DUF3531); Region: DUF3531; pfam12049 110662003005 RNA methyltransferase, RsmE family; Region: TIGR00046 110662003006 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 110662003007 Integral membrane protein DUF92; Region: DUF92; cl00793 110662003008 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 110662003009 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662003010 Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369 110662003011 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_3; cd01835 110662003012 active site 110662003013 catalytic triad [active] 110662003014 oxyanion hole [active] 110662003015 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 110662003016 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 110662003017 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 110662003018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003019 Walker A/P-loop; other site 110662003020 ATP binding site [chemical binding]; other site 110662003021 Q-loop/lid; other site 110662003022 ABC transporter signature motif; other site 110662003023 Walker B; other site 110662003024 D-loop; other site 110662003025 H-loop/switch region; other site 110662003026 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 110662003027 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 110662003028 aspartate aminotransferase; Provisional; Region: PRK05764 110662003029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 110662003030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662003031 homodimer interface [polypeptide binding]; other site 110662003032 catalytic residue [active] 110662003033 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 110662003034 active site 110662003035 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 110662003036 Fe-S cluster binding site [ion binding]; other site 110662003037 active site 110662003038 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 110662003039 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 110662003040 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 110662003041 C-terminal peptidase (prc); Region: prc; TIGR00225 110662003042 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 110662003043 protein binding site [polypeptide binding]; other site 110662003044 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 110662003045 Catalytic dyad [active] 110662003046 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 110662003047 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 110662003048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662003049 ATP binding site [chemical binding]; other site 110662003050 putative Mg++ binding site [ion binding]; other site 110662003051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662003052 nucleotide binding region [chemical binding]; other site 110662003053 ATP-binding site [chemical binding]; other site 110662003054 TRCF domain; Region: TRCF; cl04088 110662003055 Integral membrane protein TerC family; Region: TerC; cl10468 110662003056 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 110662003057 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 110662003058 putative active site [active] 110662003059 substrate binding site [chemical binding]; other site 110662003060 putative cosubstrate binding site; other site 110662003061 catalytic site [active] 110662003062 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 110662003063 substrate binding site [chemical binding]; other site 110662003064 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 110662003065 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 110662003066 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 110662003067 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 110662003068 Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047 110662003069 diiron binding motif [ion binding]; other site 110662003070 Protein of unknown function (DUF2996); Region: DUF2996; pfam11210 110662003071 aromatic acid decarboxylase; Validated; Region: PRK05920 110662003072 Flavoprotein; Region: Flavoprotein; cl08021 110662003073 Exoribonuclease R [Transcription]; Region: VacB; COG0557 110662003074 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 110662003075 RNB domain; Region: RNB; pfam00773 110662003076 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 110662003077 RNA binding site [nucleotide binding]; other site 110662003078 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 110662003079 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 110662003080 Flagellin N-methylase; Region: FliB; cl00497 110662003081 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 110662003082 DHH family; Region: DHH; pfam01368 110662003083 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 110662003084 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 110662003085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 110662003086 motif II; other site 110662003087 D-glycerate 3-kinase; Provisional; Region: PLN03046 110662003088 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003089 active site 110662003090 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 110662003091 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 110662003092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662003093 Walker A motif; other site 110662003094 ATP binding site [chemical binding]; other site 110662003095 Walker B motif; other site 110662003096 arginine finger; other site 110662003097 Peptidase family M41; Region: Peptidase_M41; pfam01434 110662003098 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 110662003099 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 110662003100 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 110662003101 dimer interface [polypeptide binding]; other site 110662003102 decamer (pentamer of dimers) interface [polypeptide binding]; other site 110662003103 catalytic triad [active] 110662003104 peroxidatic and resolving cysteines [active] 110662003105 autolysin; Reviewed; Region: PRK06347 110662003106 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 110662003107 putative peptidoglycan binding site; other site 110662003108 Peptidase family M23; Region: Peptidase_M23; pfam01551 110662003109 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 110662003110 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 110662003111 homotrimer interface [polypeptide binding]; other site 110662003112 Walker A motif; other site 110662003113 GTP binding site [chemical binding]; other site 110662003114 Walker B motif; other site 110662003115 CemA family; Region: CemA; cl03855 110662003116 Domain of unknown function (DUF477); Region: DUF477; cl01535 110662003117 tellurium resistance terB-like protein; Region: terB_like; cl11965 110662003118 metal binding site [ion binding]; metal-binding site 110662003119 Protein of unknown function (DUF2930); Region: DUF2930; pfam11152 110662003120 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 110662003121 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 110662003122 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 110662003123 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 110662003124 active site 110662003125 HIGH motif; other site 110662003126 KMSKS motif; other site 110662003127 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 110662003128 tRNA binding surface [nucleotide binding]; other site 110662003129 anticodon binding site; other site 110662003130 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 110662003131 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 110662003132 RNB domain; Region: RNB; pfam00773 110662003133 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 110662003134 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 110662003135 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 110662003136 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 110662003137 putative tRNA-binding site [nucleotide binding]; other site 110662003138 B3/4 domain; Region: B3_4; cl11458 110662003139 tRNA synthetase B5 domain; Region: B5; cl08394 110662003140 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 110662003141 dimer interface [polypeptide binding]; other site 110662003142 motif 1; other site 110662003143 motif 3; other site 110662003144 motif 2; other site 110662003145 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 110662003146 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 110662003147 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662003148 Phycobilisome protein; Region: Phycobilisome; cl08227 110662003149 Uncharacterized protein family, UPF0114; Region: UPF0114; cl01078 110662003150 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 110662003151 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 110662003152 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662003153 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 110662003154 nucleotide binding site/active site [active] 110662003155 HIT family signature motif; other site 110662003156 catalytic residue [active] 110662003157 ATP adenylyltransferase; Region: ATP_transf; pfam09830 110662003158 Stage II sporulation protein; Region: SpoIID; pfam08486 110662003159 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 110662003160 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003161 NAD(P) binding site [chemical binding]; other site 110662003162 active site 110662003163 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467 110662003164 Protein of unknown function (DUF4090); Region: DUF4090; pfam13319 110662003165 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 110662003166 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 110662003167 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 110662003168 substrate binding pocket [chemical binding]; other site 110662003169 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 110662003170 B12 binding site [chemical binding]; other site 110662003171 cobalt ligand [ion binding]; other site 110662003172 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 110662003173 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 110662003174 homodimer interface [polypeptide binding]; other site 110662003175 substrate-cofactor binding pocket; other site 110662003176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662003177 Aminotransferase class IV; Region: Aminotran_4; pfam01063 110662003178 catalytic residue [active] 110662003179 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 110662003180 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 110662003181 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 110662003182 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 110662003183 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 110662003184 Uncharacterised protein family (UPF0093); Region: UPF0093; cl00863 110662003185 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 110662003186 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 110662003187 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 110662003188 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 110662003189 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 110662003190 GIY-YIG motif/motif A; other site 110662003191 active site 110662003192 catalytic site [active] 110662003193 putative DNA binding site [nucleotide binding]; other site 110662003194 metal binding site [ion binding]; metal-binding site 110662003195 UvrB/uvrC motif; Region: UVR; pfam02151 110662003196 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 110662003197 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 110662003198 Flavin Reductases; Region: FlaRed; cl00801 110662003199 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 110662003200 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 110662003201 active site 110662003202 (T/H)XGH motif; other site 110662003203 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 110662003204 phosphodiesterase; Provisional; Region: PRK12704 110662003205 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 110662003206 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl15297 110662003207 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 110662003208 Domain of unknown function (DUF1995); Region: DUF1995; pfam09353 110662003209 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662003210 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662003211 catalytic residue [active] 110662003212 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 110662003213 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 110662003214 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 110662003215 TFIIE alpha subunit; Region: TFIIE_alpha; pfam02002 110662003216 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 110662003217 Phage integrase family; Region: Phage_integrase; pfam00589 110662003218 DNA binding site [nucleotide binding] 110662003219 Int/Topo IB signature motif; other site 110662003220 active site 110662003221 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 110662003222 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 110662003223 HIGH motif; other site 110662003224 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 110662003225 active site 110662003226 KMSKS motif; other site 110662003227 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 110662003228 tRNA binding surface [nucleotide binding]; other site 110662003229 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 110662003230 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096 110662003231 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 110662003232 active site 110662003233 dimer interface [polypeptide binding]; other site 110662003234 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 110662003235 dimer interface [polypeptide binding]; other site 110662003236 active site 110662003237 Protein of unknown function (DUF2805); Region: DUF2805; cl11923 110662003238 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 110662003239 amidase catalytic site [active] 110662003240 Zn binding residues [ion binding]; other site 110662003241 substrate binding site [chemical binding]; other site 110662003242 Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975 110662003243 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 110662003244 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 110662003245 Zn binding site [ion binding]; other site 110662003246 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 110662003247 protein binding site [polypeptide binding]; other site 110662003248 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 110662003249 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 110662003250 phosphoribosylglycinamide formyltransferase, formyltetrahydrofolate-dependent; Region: PurN; TIGR00639 110662003251 active site 110662003252 substrate binding site [chemical binding]; other site 110662003253 cosubstrate binding site; other site 110662003254 catalytic site [active] 110662003255 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 110662003256 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003257 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 110662003258 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319 110662003259 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 110662003260 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 110662003261 dimerization interface [polypeptide binding]; other site 110662003262 active site 110662003263 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 110662003264 active site 110662003265 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 110662003266 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 110662003267 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 110662003268 putative active site [active] 110662003269 Protein of unknown function (DUF3110); Region: DUF3110; pfam11360 110662003270 chaperone protein DnaJ; Provisional; Region: PRK14299 110662003271 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 110662003272 HSP70 interaction site [polypeptide binding]; other site 110662003273 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 110662003274 substrate binding site [polypeptide binding]; other site 110662003275 dimer interface [polypeptide binding]; other site 110662003276 molecular chaperone DnaK; Provisional; Region: PRK13410 110662003277 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 110662003278 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 110662003279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 110662003280 dimer interface [polypeptide binding]; other site 110662003281 conserved gate region; other site 110662003282 putative PBP binding loops; other site 110662003283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662003284 ABC-ATPase subunit interface; other site 110662003285 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 110662003286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 110662003287 dimer interface [polypeptide binding]; other site 110662003288 conserved gate region; other site 110662003289 putative PBP binding loops; other site 110662003290 ABC-ATPase subunit interface; other site 110662003291 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14259 110662003292 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 110662003293 Walker A/P-loop; other site 110662003294 ATP binding site [chemical binding]; other site 110662003295 Q-loop/lid; other site 110662003296 ABC transporter signature motif; other site 110662003297 Walker B; other site 110662003298 D-loop; other site 110662003299 H-loop/switch region; other site 110662003300 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 110662003301 catalytic loop [active] 110662003302 iron binding site [ion binding]; other site 110662003303 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 110662003304 active site 110662003305 dimerization interface [polypeptide binding]; other site 110662003306 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 110662003307 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 110662003308 dimer interface [polypeptide binding]; other site 110662003309 motif 1; other site 110662003310 active site 110662003311 motif 2; other site 110662003312 motif 3; other site 110662003313 Ferredoxin [Energy production and conversion]; Region: COG1146 110662003314 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 110662003315 heat shock protein 90; Provisional; Region: PRK05218 110662003316 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 110662003317 ATP binding site [chemical binding]; other site 110662003318 Mg2+ binding site [ion binding]; other site 110662003319 G-X-G motif; other site 110662003320 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 110662003321 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 110662003322 catalytic triad [active] 110662003323 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 110662003324 glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398 110662003325 active site 110662003326 homotetramer interface [polypeptide binding]; other site 110662003327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 110662003328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662003329 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 110662003330 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662003331 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 110662003332 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 110662003333 DNA binding site [nucleotide binding] 110662003334 Int/Topo IB signature motif; other site 110662003335 active site 110662003336 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 110662003337 Helix-turn-helix domains; Region: HTH; cl00088 110662003338 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 110662003339 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003340 Walker A/P-loop; other site 110662003341 ATP binding site [chemical binding]; other site 110662003342 Q-loop/lid; other site 110662003343 ABC transporter signature motif; other site 110662003344 Walker B; other site 110662003345 D-loop; other site 110662003346 H-loop/switch region; other site 110662003347 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 110662003348 Protein of unknown function (DUF2499); Region: DUF2499; pfam10693 110662003349 Protein of unknown function (DUF3593); Region: DUF3593; pfam12159 110662003350 Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425 110662003351 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 110662003352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003353 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 110662003354 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 110662003355 TPP-binding site; other site 110662003356 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 110662003357 PYR/PP interface [polypeptide binding]; other site 110662003358 dimer interface [polypeptide binding]; other site 110662003359 TPP binding site [chemical binding]; other site 110662003360 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 110662003361 threonine dehydratase; Reviewed; Region: PRK09224 110662003362 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 110662003363 tetramer interface [polypeptide binding]; other site 110662003364 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662003365 catalytic residue [active] 110662003366 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 110662003367 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 110662003368 putative Ile/Val binding site [chemical binding]; other site 110662003369 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 110662003370 YGGT family; Region: YGGT; cl00508 110662003371 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 110662003372 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 110662003373 pyruvate kinase; Provisional; Region: PRK05826 110662003374 domain interfaces; other site 110662003375 active site 110662003376 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 110662003377 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 110662003378 FtsX-like permease family; Region: FtsX; pfam02687 110662003379 cell division protein; Validated; Region: ftsH; CHL00176 110662003380 FtsH Extracellular; Region: FtsH_ext; pfam06480 110662003381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662003382 Walker A motif; other site 110662003383 ATP binding site [chemical binding]; other site 110662003384 Walker B motif; other site 110662003385 arginine finger; other site 110662003386 Peptidase family M41; Region: Peptidase_M41; pfam01434 110662003387 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; cl01792 110662003388 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 110662003389 oligomer interface [polypeptide binding]; other site 110662003390 active site residues [active] 110662003391 Thylakoid formation protein; Region: ThylakoidFormat; cl12138 110662003392 PetN; Region: PetN; cl15376 110662003393 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933 110662003394 Predicted metal-binding protein (DUF2103); Region: DUF2103; cl01651 110662003395 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 110662003396 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662003397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662003398 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 110662003399 active site 110662003400 dimer interface [polypeptide binding]; other site 110662003401 metal binding site [ion binding]; metal-binding site 110662003402 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 110662003403 Domain of unknown function (DUF477); Region: DUF477; cl01535 110662003404 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 110662003405 catalytic residue [active] 110662003406 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662003407 Myxococcus xanthus DevT and related proteins, metallophosphatase domain; Region: MPP_DevT; cd07397 110662003408 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 110662003409 putative active site [active] 110662003410 putative metal binding site [ion binding]; other site 110662003411 Quinolinate synthetase A protein; Region: NadA; cl00420 110662003412 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 110662003413 catalytic residues [active] 110662003414 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 110662003415 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662003416 ATP-dependent DNA ligase; Validated; Region: PRK09247 110662003417 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 110662003418 active site 110662003419 DNA binding site [nucleotide binding] 110662003420 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 110662003421 DNA binding site [nucleotide binding] 110662003422 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 110662003423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662003424 ATP binding site [chemical binding]; other site 110662003425 putative Mg++ binding site [ion binding]; other site 110662003426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662003427 nucleotide binding region [chemical binding]; other site 110662003428 ATP-binding site [chemical binding]; other site 110662003429 DEAD/H associated; Region: DEAD_assoc; pfam08494 110662003430 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 110662003431 Domain of Unknown Function (DUF1543); Region: DUF1543; pfam07566 110662003432 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 110662003433 HSP70 interaction site [polypeptide binding]; other site 110662003434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662003435 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 110662003436 light-harvesting-like protein 3; Provisional; Region: PLN00014 110662003437 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 110662003438 nudix motif; other site 110662003439 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 110662003440 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 110662003441 Walker A/P-loop; other site 110662003442 ATP binding site [chemical binding]; other site 110662003443 Q-loop/lid; other site 110662003444 ABC transporter signature motif; other site 110662003445 Walker B; other site 110662003446 D-loop; other site 110662003447 H-loop/switch region; other site 110662003448 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 110662003449 ABC-ATPase subunit interface; other site 110662003450 dimer interface [polypeptide binding]; other site 110662003451 putative PBP binding regions; other site 110662003452 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662003453 putative acyl-acceptor binding pocket; other site 110662003454 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 110662003455 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 110662003456 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 110662003457 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 110662003458 metal binding site [ion binding]; metal-binding site 110662003459 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 110662003460 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 110662003461 minor groove reading motif; other site 110662003462 helix-hairpin-helix signature motif; other site 110662003463 substrate binding pocket [chemical binding]; other site 110662003464 active site 110662003465 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 110662003466 catalytic loop [active] 110662003467 iron binding site [ion binding]; other site 110662003468 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 110662003469 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 110662003470 active site 110662003471 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 110662003472 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 110662003473 Protein of unknown function, DUF393; Region: DUF393; cl01136 110662003474 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 110662003475 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 110662003476 putative NAD(P) binding site [chemical binding]; other site 110662003477 hypothetical protein; Provisional; Region: PRK11770 110662003478 Domain of unknown function (DUF307); Region: DUF307; pfam03733 110662003479 Domain of unknown function (DUF307); Region: DUF307; pfam03733 110662003480 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 110662003481 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 110662003482 E-class dimer interface [polypeptide binding]; other site 110662003483 P-class dimer interface [polypeptide binding]; other site 110662003484 active site 110662003485 Cu2+ binding site [ion binding]; other site 110662003486 Zn2+ binding site [ion binding]; other site 110662003487 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 110662003488 RNA/DNA binding site [nucleotide binding]; other site 110662003489 RRM dimerization site [polypeptide binding]; other site 110662003490 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 110662003491 active site 110662003492 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 110662003493 Bacterial protein of unknown function (DUF924); Region: DUF924; cl01561 110662003494 Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428 110662003495 Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696 110662003496 tellurite resistance protein terB; Region: terB; cd07176 110662003497 putative metal binding site [ion binding]; other site 110662003498 Protein of unknown function (DUF805); Region: DUF805; cl01224 110662003499 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 110662003500 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 110662003501 Lipocalin-like domain; Region: Lipocalin_5; pfam13924 110662003502 Cytochrome P450; Region: p450; cl12078 110662003503 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662003504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662003505 active site 110662003506 phosphorylation site [posttranslational modification] 110662003507 intermolecular recognition site; other site 110662003508 Protein of unknown function (DUF429); Region: DUF429; cl12046 110662003509 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 110662003510 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 110662003511 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 110662003512 putative active site [active] 110662003513 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003514 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 110662003515 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 110662003516 Protein of unknown function (DUF1651); Region: DUF1651; pfam07864 110662003517 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 110662003518 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 110662003519 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 110662003520 Coenzyme A binding pocket [chemical binding]; other site 110662003521 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 110662003522 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003523 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 110662003524 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 110662003525 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 110662003526 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 110662003527 metal binding site [ion binding]; metal-binding site 110662003528 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 110662003529 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003530 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458 110662003531 Protein of unknown function; Region: DUF3721; pfam12518 110662003532 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 110662003533 Helix-turn-helix domains; Region: HTH; cl00088 110662003534 S-layer homology domain; Region: SLH; pfam00395 110662003535 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 110662003536 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 110662003537 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 110662003538 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 110662003539 Ferritin-like domain; Region: Ferritin; pfam00210 110662003540 ferroxidase diiron center [ion binding]; other site 110662003541 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 110662003542 catalytic loop [active] 110662003543 iron binding site [ion binding]; other site 110662003544 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 110662003545 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 110662003546 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 110662003547 Helix-turn-helix domains; Region: HTH; cl00088 110662003548 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 110662003549 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 110662003550 Photosystem II protein; Region: PSII; cl08223 110662003551 S-layer homology domain; Region: SLH; pfam00395 110662003552 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 110662003553 5-oxoprolinase; Region: PLN02666 110662003554 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 110662003555 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 110662003556 Predicted permease; Region: DUF318; cl00487 110662003557 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 110662003558 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 110662003559 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 110662003560 intersubunit interface [polypeptide binding]; other site 110662003561 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 110662003562 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 110662003563 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 110662003564 dimer interface [polypeptide binding]; other site 110662003565 putative PBP binding regions; other site 110662003566 ABC-ATPase subunit interface; other site 110662003567 Uncharacterised BCR, COG1649; Region: DUF187; cl15398 110662003568 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 110662003569 ribose-phosphate pyrophosphokinase; Region: PLN02369 110662003570 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 110662003571 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 110662003572 NmrA-like family; Region: NmrA; pfam05368 110662003573 NAD(P) binding site [chemical binding]; other site 110662003574 putative active site [active] 110662003575 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 110662003576 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 110662003577 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 110662003578 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 110662003579 RNA binding surface [nucleotide binding]; other site 110662003580 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 110662003581 active site 110662003582 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 110662003583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080 110662003584 dimer interface [polypeptide binding]; other site 110662003585 phosphorylation site [posttranslational modification] 110662003586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 110662003587 ATP binding site [chemical binding]; other site 110662003588 Mg2+ binding site [ion binding]; other site 110662003589 G-X-G motif; other site 110662003590 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 110662003591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662003592 active site 110662003593 phosphorylation site [posttranslational modification] 110662003594 intermolecular recognition site; other site 110662003595 dimerization interface [polypeptide binding]; other site 110662003596 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662003597 DNA binding site [nucleotide binding] 110662003598 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 110662003599 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662003600 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662003601 catalytic residue [active] 110662003602 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 110662003603 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 110662003604 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 110662003605 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 110662003606 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 110662003607 Uncharacterised protein family (UPF0227); Region: UPF0227; cl14886 110662003608 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 110662003609 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 110662003610 putative active site [active] 110662003611 metal binding site [ion binding]; metal-binding site 110662003612 Clp protease ATP binding subunit; Region: clpC; CHL00095 110662003613 Clp amino terminal domain; Region: Clp_N; pfam02861 110662003614 Clp amino terminal domain; Region: Clp_N; pfam02861 110662003615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662003616 Walker A motif; other site 110662003617 ATP binding site [chemical binding]; other site 110662003618 Walker B motif; other site 110662003619 arginine finger; other site 110662003620 UvrB/uvrC motif; Region: UVR; pfam02151 110662003621 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662003622 Walker A motif; other site 110662003623 ATP binding site [chemical binding]; other site 110662003624 Walker B motif; other site 110662003625 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 110662003626 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 110662003627 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662003628 diaminopimelate decarboxylase; Region: lysA; TIGR01048 110662003629 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 110662003630 active site 110662003631 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 110662003632 substrate binding site [chemical binding]; other site 110662003633 catalytic residues [active] 110662003634 dimer interface [polypeptide binding]; other site 110662003635 TIGR00159 family protein; Region: TIGR00159 110662003636 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 110662003637 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 110662003638 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 110662003639 catalytic residue [active] 110662003640 putative FPP diphosphate binding site; other site 110662003641 putative FPP binding hydrophobic cleft; other site 110662003642 dimer interface [polypeptide binding]; other site 110662003643 putative IPP diphosphate binding site; other site 110662003644 biotin synthase; Region: bioB; TIGR00433 110662003645 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662003646 FeS/SAM binding site; other site 110662003647 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 110662003648 Cupin domain; Region: Cupin_2; cl09118 110662003649 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 110662003650 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 110662003651 active site residue [active] 110662003652 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 110662003653 GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060 110662003654 putative GSH binding site (G-site) [chemical binding]; other site 110662003655 active site cysteine [active] 110662003656 putative C-terminal domain interface [polypeptide binding]; other site 110662003657 putative dimer interface [polypeptide binding]; other site 110662003658 C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196 110662003659 putative N-terminal domain interface [polypeptide binding]; other site 110662003660 putative dimer interface [polypeptide binding]; other site 110662003661 putative substrate binding pocket (H-site) [chemical binding]; other site 110662003662 Protein of unknown function (DUF952); Region: DUF952; cl01393 110662003663 lipoyl synthase; Provisional; Region: PRK12928 110662003664 recombination protein RecR; Reviewed; Region: recR; PRK00076 110662003665 RecR protein; Region: RecR; pfam02132 110662003666 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 110662003667 putative active site [active] 110662003668 putative metal-binding site [ion binding]; other site 110662003669 tetramer interface [polypeptide binding]; other site 110662003670 PsbP; Region: PsbP; cl03356 110662003671 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 110662003672 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 110662003673 The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988 110662003674 Ligand Binding Site [chemical binding]; other site 110662003675 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 110662003676 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662003677 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003678 Walker A/P-loop; other site 110662003679 ATP binding site [chemical binding]; other site 110662003680 Q-loop/lid; other site 110662003681 ABC transporter signature motif; other site 110662003682 Walker B; other site 110662003683 D-loop; other site 110662003684 H-loop/switch region; other site 110662003685 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 110662003686 RNA/DNA binding site [nucleotide binding]; other site 110662003687 RRM dimerization site [polypeptide binding]; other site 110662003688 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 110662003689 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 110662003690 ATP binding site [chemical binding]; other site 110662003691 Mg++ binding site [ion binding]; other site 110662003692 motif III; other site 110662003693 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662003694 nucleotide binding region [chemical binding]; other site 110662003695 ATP-binding site [chemical binding]; other site 110662003696 DbpA RNA binding domain; Region: DbpA; pfam03880 110662003697 Cupin domain; Region: Cupin_2; cl09118 110662003698 exodeoxyribonuclease V, alpha subunit; Region: recD; TIGR01447 110662003699 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003700 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 110662003701 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003702 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003703 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 110662003704 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 110662003705 bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625 110662003706 active site 110662003707 metal binding site [ion binding]; metal-binding site 110662003708 Protein of unknown function (DUF2488); Region: Ycf54; pfam10674 110662003709 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 110662003710 active site 110662003711 hydrophilic channel; other site 110662003712 dimerization interface [polypeptide binding]; other site 110662003713 catalytic residues [active] 110662003714 active site lid [active] 110662003715 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 110662003716 putative acyl-acceptor binding pocket; other site 110662003717 BolA-like protein; Region: BolA; cl00386 110662003718 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 110662003719 putative GSH binding site [chemical binding]; other site 110662003720 catalytic residues [active] 110662003721 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 110662003722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662003723 active site 110662003724 phosphorylation site [posttranslational modification] 110662003725 intermolecular recognition site; other site 110662003726 dimerization interface [polypeptide binding]; other site 110662003727 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662003728 DNA binding site [nucleotide binding] 110662003729 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662003730 Phage integrase family; Region: Phage_integrase; pfam00589 110662003731 DNA binding site [nucleotide binding] 110662003732 Int/Topo IB signature motif; other site 110662003733 active site 110662003734 catalytic residues [active] 110662003735 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 110662003736 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 110662003737 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 110662003738 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003739 Cation efflux family; Region: Cation_efflux; cl00316 110662003740 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 110662003741 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 110662003742 Photosystem II protein Y (PsbY); Region: PsbY; cl05675 110662003743 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 110662003744 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 110662003745 trimer interface [polypeptide binding]; other site 110662003746 putative metal binding site [ion binding]; other site 110662003747 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 110662003748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003749 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003750 Walker A motif; other site 110662003751 ATP binding site [chemical binding]; other site 110662003752 Walker B motif; other site 110662003753 acyl-coenzyme A oxidase; Region: PLN02443 110662003754 Phage terminase large subunit; Region: Terminase_3; cl12054 110662003755 Terminase-like family; Region: Terminase_6; pfam03237 110662003756 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 110662003757 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 110662003758 Phage integrase family; Region: Phage_integrase; pfam00589 110662003759 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662003760 DNA binding site [nucleotide binding] 110662003761 Int/Topo IB signature motif; other site 110662003762 active site 110662003763 catalytic residues [active] 110662003764 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 110662003765 Predicted transcriptional regulator [General function prediction only]; Region: COG2522 110662003766 Phage terminase large subunit; Region: Terminase_3; cl12054 110662003767 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 110662003768 protein disaggregation chaperone; Provisional; Region: PRK10865 110662003769 Phage integrase family; Region: Phage_integrase; pfam00589 110662003770 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662003771 DNA binding site [nucleotide binding] 110662003772 Int/Topo IB signature motif; other site 110662003773 active site 110662003774 catalytic residues [active] 110662003775 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 110662003776 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 110662003777 Protein of unknown function (DUF3303); Region: DUF3303; pfam11746 110662003778 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 110662003779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662003780 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 110662003781 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 110662003782 substrate binding site [chemical binding]; other site 110662003783 ATP binding site [chemical binding]; other site 110662003784 Domain of unknown function (DUF427); Region: DUF427; cl00998 110662003785 light-harvesting-like protein 3; Provisional; Region: PLN00014 110662003786 Domain of unknown function (DUF427); Region: DUF427; cl00998 110662003787 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 110662003788 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 110662003789 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 110662003790 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 110662003791 conserved hypothetical protein; Region: TIGR02466 110662003792 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 110662003793 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 110662003794 active site 110662003795 metal binding site [ion binding]; metal-binding site 110662003796 hexamer interface [polypeptide binding]; other site 110662003797 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 110662003798 Protein of unknown function (DUF3764); Region: DUF3764; pfam12594 110662003799 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 110662003800 metal binding site 2 [ion binding]; metal-binding site 110662003801 putative DNA binding helix; other site 110662003802 metal binding site 1 [ion binding]; metal-binding site 110662003803 dimer interface [polypeptide binding]; other site 110662003804 structural Zn2+ binding site [ion binding]; other site 110662003805 GLTT repeat (6 copies); Region: GLTT; pfam01744 110662003806 Protein of unknown function; Region: DUF3721; pfam12518 110662003807 Protein of unknown function; Region: DUF3721; pfam12518 110662003808 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 110662003809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662003810 FeS/SAM binding site; other site 110662003811 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 110662003812 glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399 110662003813 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506 110662003814 Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480 110662003815 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 110662003816 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 110662003817 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 110662003818 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 110662003819 putative C-terminal domain interface [polypeptide binding]; other site 110662003820 putative GSH binding site (G-site) [chemical binding]; other site 110662003821 putative dimer interface [polypeptide binding]; other site 110662003822 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 110662003823 dimer interface [polypeptide binding]; other site 110662003824 substrate binding pocket (H-site) [chemical binding]; other site 110662003825 N-terminal domain interface [polypeptide binding]; other site 110662003826 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662003827 DNA binding site [nucleotide binding] 110662003828 Int/Topo IB signature motif; other site 110662003829 active site 110662003830 catalytic residues [active] 110662003831 Protein of unknown function (DUF2973); Region: DUF2973; pfam11189 110662003832 Phosphotransferase enzyme family; Region: APH; pfam01636 110662003833 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 110662003834 active site 110662003835 ATP binding site [chemical binding]; other site 110662003836 substrate binding site [chemical binding]; other site 110662003837 Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627 110662003838 putative heme binding site [chemical binding]; other site 110662003839 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 110662003840 N-acetyl-D-glucosamine binding site [chemical binding]; other site 110662003841 catalytic residue [active] 110662003842 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 110662003843 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 110662003844 homodimer interface [polypeptide binding]; other site 110662003845 substrate-cofactor binding pocket; other site 110662003846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662003847 catalytic residue [active] 110662003848 Homoserine O-succinyltransferase; Region: HTS; pfam04204 110662003849 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 110662003850 conserved cys residue [active] 110662003851 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 110662003852 Membrane transport protein; Region: Mem_trans; cl09117 110662003853 AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250 110662003854 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 110662003855 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 110662003856 Walker A/P-loop; other site 110662003857 ATP binding site [chemical binding]; other site 110662003858 Q-loop/lid; other site 110662003859 ABC transporter signature motif; other site 110662003860 Walker B; other site 110662003861 D-loop; other site 110662003862 H-loop/switch region; other site 110662003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 110662003864 dimer interface [polypeptide binding]; other site 110662003865 conserved gate region; other site 110662003866 putative PBP binding loops; other site 110662003867 ABC-ATPase subunit interface; other site 110662003868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 110662003869 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 110662003870 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 110662003871 substrate binding pocket [chemical binding]; other site 110662003872 membrane-bound complex binding site; other site 110662003873 hinge residues; other site 110662003874 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 110662003875 Permease family; Region: Xan_ur_permease; cl00967 110662003876 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 110662003877 FAD binding domain; Region: FAD_binding_4; pfam01565 110662003878 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 110662003879 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 110662003880 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 110662003881 putative active site [active] 110662003882 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 110662003883 putative active site [active] 110662003884 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 110662003885 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 110662003886 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 110662003887 L-asparaginase II; Region: Asparaginase_II; cl01842 110662003888 Protein of unknown function (DUF1230); Region: DUF1230; pfam06799 110662003889 Domain of unknown function DUF143; Region: DUF143; cl00519 110662003890 Protein of unknown function (DUF3318); Region: DUF3318; pfam11780 110662003891 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 110662003892 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 110662003893 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662003894 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 110662003895 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662003896 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 110662003897 IMP binding site; other site 110662003898 dimer interface [polypeptide binding]; other site 110662003899 interdomain contacts; other site 110662003900 partial ornithine binding site; other site 110662003901 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 110662003902 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 110662003903 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662003904 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 110662003905 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003906 Walker A/P-loop; other site 110662003907 ATP binding site [chemical binding]; other site 110662003908 Q-loop/lid; other site 110662003909 ABC transporter signature motif; other site 110662003910 Walker B; other site 110662003911 D-loop; other site 110662003912 H-loop/switch region; other site 110662003913 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 110662003914 RNA binding surface [nucleotide binding]; other site 110662003915 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 110662003916 substrate binding site [chemical binding]; other site 110662003917 dimer interface [polypeptide binding]; other site 110662003918 catalytic triad [active] 110662003919 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 110662003920 dihydropteroate synthase; Region: DHPS; TIGR01496 110662003921 substrate binding pocket [chemical binding]; other site 110662003922 dimer interface [polypeptide binding]; other site 110662003923 inhibitor binding site; inhibition site 110662003924 Glycosyltransferase (GlcNAc); Region: GlcNAc; pfam11397 110662003925 magnesium chelatase subunit H; Provisional; Region: PRK12493 110662003926 Domain of unknown function (DUF3479); Region: DUF3479; pfam11965 110662003927 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 110662003928 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 110662003929 dihydrodipicolinate reductase; Provisional; Region: PRK00048 110662003930 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003931 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 110662003932 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003933 Protein of unknown function (DUF2949); Region: DUF2949; pfam11165 110662003934 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 110662003935 Protein of unknown function (DUF3038); Region: DUF3038; pfam11237 110662003936 Domain of unknown function (DUF4335); Region: DUF4335; pfam14233 110662003937 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 110662003938 Ca2+ binding site [ion binding]; other site 110662003939 osmolarity response regulator; Provisional; Region: ompR; PRK09468 110662003940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662003941 active site 110662003942 phosphorylation site [posttranslational modification] 110662003943 intermolecular recognition site; other site 110662003944 dimerization interface [polypeptide binding]; other site 110662003945 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662003946 DNA binding site [nucleotide binding] 110662003947 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 110662003948 dimerization interface [polypeptide binding]; other site 110662003949 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 110662003950 dimer interface [polypeptide binding]; other site 110662003951 phosphorylation site [posttranslational modification] 110662003952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 110662003953 ATP binding site [chemical binding]; other site 110662003954 Mg2+ binding site [ion binding]; other site 110662003955 G-X-G motif; other site 110662003956 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662003957 active site 110662003958 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955 110662003959 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 110662003960 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 110662003961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 110662003962 dimerization interface [polypeptide binding]; other site 110662003963 putative DNA binding site [nucleotide binding]; other site 110662003964 putative Zn2+ binding site [ion binding]; other site 110662003965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662003966 Mechanosensitive ion channel; Region: MS_channel; pfam00924 110662003967 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 110662003968 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 110662003969 putative active site [active] 110662003970 catalytic triad [active] 110662003971 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 110662003972 dimer interface [polypeptide binding]; other site 110662003973 catalytic triad [active] 110662003974 Domain of unknown function DUF11; Region: DUF11; cl15273 110662003975 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 110662003976 hypothetical protein; Provisional; Region: PRK08185 110662003977 intersubunit interface [polypeptide binding]; other site 110662003978 active site 110662003979 zinc binding site [ion binding]; other site 110662003980 Na+ binding site [ion binding]; other site 110662003981 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662003982 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 110662003983 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 110662003984 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 110662003985 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 110662003986 active site 110662003987 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 110662003988 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 110662003989 trimer interface [polypeptide binding]; other site 110662003990 active site 110662003991 UDP-GlcNAc binding site [chemical binding]; other site 110662003992 lipid binding site [chemical binding]; lipid-binding site 110662003993 gamma-glutamyl kinase; Provisional; Region: PRK05429 110662003994 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 110662003995 nucleotide binding site [chemical binding]; other site 110662003996 homotetrameric interface [polypeptide binding]; other site 110662003997 putative phosphate binding site [ion binding]; other site 110662003998 putative allosteric binding site; other site 110662003999 PUA domain; Region: PUA; cl00607 110662004000 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 110662004001 active site 110662004002 motif I; other site 110662004003 motif II; other site 110662004004 Protein of unknown function (DUF3727); Region: DUF3727; pfam12527 110662004005 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 110662004006 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 110662004007 Protein of unknown function (DUF3685); Region: DUF3685; pfam12452 110662004008 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 110662004009 metal binding site 2 [ion binding]; metal-binding site 110662004010 putative DNA binding helix; other site 110662004011 metal binding site 1 [ion binding]; metal-binding site 110662004012 dimer interface [polypeptide binding]; other site 110662004013 structural Zn2+ binding site [ion binding]; other site 110662004014 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 110662004015 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 110662004016 catalytic residues [active] 110662004017 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 110662004018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004019 NAD(P) binding site [chemical binding]; other site 110662004020 active site 110662004021 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 110662004022 FOG: CBS domain [General function prediction only]; Region: COG0517 110662004023 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 110662004024 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 110662004025 catalytic loop [active] 110662004026 iron binding site [ion binding]; other site 110662004027 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 110662004028 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 110662004029 trimer interface [polypeptide binding]; other site 110662004030 active site 110662004031 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 110662004032 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 110662004033 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 110662004034 putative active site [active] 110662004035 putative metal binding site [ion binding]; other site 110662004036 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 110662004037 Domain of unknown function (DUF296); Region: DUF296; cl00720 110662004038 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 110662004039 GSH binding site [chemical binding]; other site 110662004040 catalytic residues [active] 110662004041 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 110662004042 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004043 Rhomboid family; Region: Rhomboid; cl11446 110662004044 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 110662004045 AhpC/TSA antioxidant enzyme; Region: AhpC-TSA_2; pfam13911 110662004046 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 110662004047 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 110662004048 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 110662004049 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004050 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004051 transcription initiation factor IIB; Reviewed; Region: tfb; PRK00423 110662004052 aminopeptidase N; Provisional; Region: pepN; PRK14015 110662004053 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 110662004054 Zn binding site [ion binding]; other site 110662004055 adaptive-response sensory kinase; Validated; Region: PRK09303 110662004056 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 110662004057 tetramer interface [polypeptide binding]; other site 110662004058 dimer interface [polypeptide binding]; other site 110662004059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 110662004060 ATP binding site [chemical binding]; other site 110662004061 Mg2+ binding site [ion binding]; other site 110662004062 G-X-G motif; other site 110662004063 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 110662004064 hydrophobic ligand binding site; other site 110662004065 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 110662004066 ferredoxin--NADP+ reductase; Provisional; Region: PLN03116 110662004067 These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208 110662004068 dimerization interface [polypeptide binding]; other site 110662004069 FAD binding pocket [chemical binding]; other site 110662004070 FAD binding motif [chemical binding]; other site 110662004071 catalytic residues [active] 110662004072 NAD binding pocket [chemical binding]; other site 110662004073 phosphate binding motif [ion binding]; other site 110662004074 beta-alpha-beta structure motif; other site 110662004075 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 110662004076 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 110662004077 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 110662004078 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359 110662004079 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 110662004080 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 110662004081 catalytic triad [active] 110662004082 Acylphosphatase; Region: Acylphosphatase; cl00551 110662004083 LysE type translocator; Region: LysE; cl00565 110662004084 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 110662004085 ATP-dependent exoDNAse (exonuclease V), alpha subunit - helicase superfamily I member [DNA replication, recombination, and repair]; Region: RecD; COG0507 110662004086 Divergent PAP2 family; Region: DUF212; cl00855 110662004087 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 110662004088 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 110662004089 substrate binding pocket [chemical binding]; other site 110662004090 chain length determination region; other site 110662004091 substrate-Mg2+ binding site; other site 110662004092 catalytic residues [active] 110662004093 aspartate-rich region 1; other site 110662004094 active site lid residues [active] 110662004095 aspartate-rich region 2; other site 110662004096 conserved hypothetical protein; Region: TIGR02466 110662004097 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186 110662004098 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 110662004099 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 110662004100 homodimer interface [polypeptide binding]; other site 110662004101 NADP binding site [chemical binding]; other site 110662004102 substrate binding site [chemical binding]; other site 110662004103 7TM-HD extracellular; Region: 7TMR-HDED; pfam07697 110662004104 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 110662004105 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 110662004106 Zn2+ binding site [ion binding]; other site 110662004107 Mg2+ binding site [ion binding]; other site 110662004108 PQ loop repeat; Region: PQ-loop; cl12056 110662004109 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 110662004110 active site 110662004111 Domain of unknown function DUF77; Region: DUF77; cl00307 110662004112 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 110662004113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 110662004114 dimer interface [polypeptide binding]; other site 110662004115 conserved gate region; other site 110662004116 putative PBP binding loops; other site 110662004117 ABC-ATPase subunit interface; other site 110662004118 2-isopropylmalate synthase; Validated; Region: PRK00915 110662004119 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 110662004120 active site 110662004121 catalytic residues [active] 110662004122 metal binding site [ion binding]; metal-binding site 110662004123 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 110662004124 Uncharacterized conserved protein [Function unknown]; Region: COG1543 110662004125 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 110662004126 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004127 lycopene cyclase family protein; Region: carotene-cycl; TIGR01790 110662004128 DNA gyrase subunit A; Validated; Region: PRK05560 110662004129 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 110662004130 CAP-like domain; other site 110662004131 active site 110662004132 primary dimer interface [polypeptide binding]; other site 110662004133 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 110662004134 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 110662004135 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 110662004136 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 110662004137 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 110662004138 photosystem I P subunit (PSI-P); Region: PLN02777 110662004139 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 110662004140 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 110662004141 active site 110662004142 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 110662004143 catalytic residues [active] 110662004144 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 110662004145 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 110662004146 putative active site [active] 110662004147 oxyanion strand; other site 110662004148 catalytic triad [active] 110662004149 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662004150 S-adenosylmethionine binding site [chemical binding]; other site 110662004151 Cytochrome B6-F complex subunit 5; Region: PetG; cl03637 110662004152 Cytochrome c; Region: Cytochrom_C; cl11414 110662004153 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 110662004154 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 110662004155 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 110662004156 Protein of unknown function (DUF3370); Region: DUF3370; pfam11850 110662004157 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662004158 magnesium chelatase ATPase subunit I; Region: BchI-ChlI; TIGR02030 110662004159 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 110662004160 active site 110662004161 putative DNA-binding cleft [nucleotide binding]; other site 110662004162 dimer interface [polypeptide binding]; other site 110662004163 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 110662004164 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 110662004165 Fe-S metabolism associated domain; Region: SufE; cl00951 110662004166 homoserine dehydrogenase; Provisional; Region: PRK06349 110662004167 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004168 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 110662004169 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 110662004170 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 110662004171 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 110662004172 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 110662004173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 110662004174 ABC-ATPase subunit interface; other site 110662004175 putative PBP binding loops; other site 110662004176 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 110662004177 AAA domain; Region: AAA_33; pfam13671 110662004178 GTP-binding protein YchF; Reviewed; Region: PRK09601 110662004179 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 110662004180 G1 box; other site 110662004181 GTP/Mg2+ binding site [chemical binding]; other site 110662004182 Switch I region; other site 110662004183 G2 box; other site 110662004184 Switch II region; other site 110662004185 G3 box; other site 110662004186 G4 box; other site 110662004187 G5 box; other site 110662004188 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 110662004189 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 110662004190 DNA polymerase I; Provisional; Region: PRK05755 110662004191 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 110662004192 active site 110662004193 metal binding site 1 [ion binding]; metal-binding site 110662004194 putative 5' ssDNA interaction site; other site 110662004195 metal binding site 3; metal-binding site 110662004196 metal binding site 2 [ion binding]; metal-binding site 110662004197 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 110662004198 putative DNA binding site [nucleotide binding]; other site 110662004199 putative metal binding site [ion binding]; other site 110662004200 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 110662004201 active site 110662004202 catalytic site [active] 110662004203 substrate binding site [chemical binding]; other site 110662004204 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 110662004205 active site 110662004206 DNA binding site [nucleotide binding] 110662004207 catalytic site [active] 110662004208 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 110662004209 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 110662004210 active site 110662004211 HIGH motif; other site 110662004212 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 110662004213 KMSKS motif; other site 110662004214 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 110662004215 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 110662004216 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 110662004217 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 110662004218 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 110662004219 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 110662004220 dimer interface [polypeptide binding]; other site 110662004221 [2Fe-2S] cluster binding site [ion binding]; other site 110662004222 Fatty acid desaturase; Region: FA_desaturase; pfam00487 110662004223 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 110662004224 putative di-iron ligands [ion binding]; other site 110662004225 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 110662004226 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 110662004227 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 110662004228 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 110662004229 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 110662004230 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 110662004231 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 110662004232 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004233 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662004234 ATP binding site [chemical binding]; other site 110662004235 putative Mg++ binding site [ion binding]; other site 110662004236 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662004237 nucleotide binding region [chemical binding]; other site 110662004238 ATP-binding site [chemical binding]; other site 110662004239 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 110662004240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004241 TRX domain, novel NADPH thioredoxin reductase (NTR) family; composed of fusion proteins found only in oxygenic photosynthetic organisms containing both TRX and NTR domains. The TRX domain functions as a protein disulfide reductase via the reversible...; Region: TRX_NTR; cd02949 110662004242 catalytic residues [active] 110662004243 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 110662004244 rRNA binding site [nucleotide binding]; other site 110662004245 predicted 30S ribosome binding site; other site 110662004246 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 110662004247 pseudouridine synthase; Region: TIGR00093 110662004248 active site 110662004249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662004250 S-adenosylmethionine binding site [chemical binding]; other site 110662004251 Ycf39; Provisional; Region: ycf39; CHL00194 110662004252 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 110662004253 NAD(P) binding site [chemical binding]; other site 110662004254 putative active site [active] 110662004255 PetM family of cytochrome b6f complex subunit 7; Region: PetM; cl15715 110662004256 N2,N2-dimethylguanosine tRNA methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TRM1; COG1867 110662004257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662004258 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662004259 hydrolase, alpha/beta fold family protein; Region: PLN02679 110662004260 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 110662004261 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 110662004262 putative valine binding site [chemical binding]; other site 110662004263 dimer interface [polypeptide binding]; other site 110662004264 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 110662004265 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 110662004266 active site 110662004267 Ycf4; Region: Ycf4; cl03567 110662004268 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 110662004269 D1 interface; other site 110662004270 chlorophyll binding site; other site 110662004271 pheophytin binding site; other site 110662004272 beta carotene binding site; other site 110662004273 cytochrome b559 beta interface; other site 110662004274 quinone binding site; other site 110662004275 cytochrome b559 alpha interface; other site 110662004276 protein J interface; other site 110662004277 protein H interface; other site 110662004278 protein X interface; other site 110662004279 core light harvesting protein interface; other site 110662004280 protein L interface; other site 110662004281 CP43 interface; other site 110662004282 protein T interface; other site 110662004283 Fe binding site [ion binding]; other site 110662004284 protein M interface; other site 110662004285 Mn-stabilizing polypeptide interface; other site 110662004286 bromide binding site; other site 110662004287 cytochrome c-550 interface; other site 110662004288 Photosystem II protein; Region: PSII; cl08223 110662004289 photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153 110662004290 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 110662004291 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 110662004292 homodimer interface [polypeptide binding]; other site 110662004293 substrate-cofactor binding pocket; other site 110662004294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662004295 catalytic residue [active] 110662004296 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 110662004297 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662004298 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662004299 catalytic residue [active] 110662004300 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 110662004301 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 110662004302 dimer interface [polypeptide binding]; other site 110662004303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662004304 catalytic residue [active] 110662004305 Predicted membrane protein [Function unknown]; Region: COG2119 110662004306 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 110662004307 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 110662004308 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 110662004309 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 110662004310 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 110662004311 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 110662004312 Protein of unknown function (DUF1345); Region: DUF1345; cl01753 110662004313 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 110662004314 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 110662004315 active site clefts [active] 110662004316 zinc binding site [ion binding]; other site 110662004317 dimer interface [polypeptide binding]; other site 110662004318 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 110662004319 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 110662004320 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 110662004321 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 110662004322 E3 interaction surface; other site 110662004323 lipoyl attachment site [posttranslational modification]; other site 110662004324 e3 binding domain; Region: E3_binding; pfam02817 110662004325 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 110662004326 Protein of unknown function (DUF2869); Region: DUF2869; pfam11068 110662004327 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 110662004328 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 110662004329 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 110662004330 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 110662004331 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 110662004332 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 110662004333 30S subunit binding site; other site 110662004334 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 110662004335 intersubunit interface [polypeptide binding]; other site 110662004336 active site 110662004337 catalytic residue [active] 110662004338 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 110662004339 Recombination protein O N terminal; Region: RecO_N; pfam11967 110662004340 Recombination protein O C terminal; Region: RecO_C; pfam02565 110662004341 H+ Antiporter protein; Region: 2A0121; TIGR00900 110662004342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 110662004343 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 110662004344 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 110662004345 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 110662004346 Cupin domain; Region: Cupin_2; cl09118 110662004347 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 110662004348 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 110662004349 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004350 Protein of unknown function (DUF552); Region: DUF552; cl00775 110662004351 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 110662004352 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 110662004353 catalytic residue [active] 110662004354 Protein of unknown function (DUF3539); Region: DUF3539; pfam12058 110662004355 Cobalt transport protein; Region: CbiQ; cl00463 110662004356 GTP-binding protein Der; Reviewed; Region: PRK00093 110662004357 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 110662004358 G1 box; other site 110662004359 GTP/Mg2+ binding site [chemical binding]; other site 110662004360 Switch I region; other site 110662004361 G2 box; other site 110662004362 Switch II region; other site 110662004363 G3 box; other site 110662004364 G4 box; other site 110662004365 G5 box; other site 110662004366 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 110662004367 G1 box; other site 110662004368 GTP/Mg2+ binding site [chemical binding]; other site 110662004369 Switch I region; other site 110662004370 G2 box; other site 110662004371 G3 box; other site 110662004372 Switch II region; other site 110662004373 G4 box; other site 110662004374 G5 box; other site 110662004375 Domain of unknown function (DUF1823); Region: DUF1823; pfam08853 110662004376 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 110662004377 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 110662004378 FMN binding site [chemical binding]; other site 110662004379 active site 110662004380 catalytic residues [active] 110662004381 substrate binding site [chemical binding]; other site 110662004382 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 110662004383 Probable Catalytic site; other site 110662004384 metal-binding site 110662004385 Rhamnan synthesis protein F; Region: RgpF; cl01529 110662004386 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 110662004387 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 110662004388 substrate binding site; other site 110662004389 tetramer interface; other site 110662004390 Cupin domain; Region: Cupin_2; cl09118 110662004391 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 110662004392 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 110662004393 NADP binding site [chemical binding]; other site 110662004394 active site 110662004395 putative substrate binding site [chemical binding]; other site 110662004396 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 110662004397 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 110662004398 NAD binding site [chemical binding]; other site 110662004399 substrate binding site [chemical binding]; other site 110662004400 homodimer interface [polypeptide binding]; other site 110662004401 active site 110662004402 Rhamnan synthesis protein F; Region: RgpF; cl01529 110662004403 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662004404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 110662004405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 110662004406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 110662004407 active site 110662004408 Vi polysaccharide export inner membrane protein VexD; Provisional; Region: PRK15178 110662004409 ABC-2 type transporter; Region: ABC2_membrane; cl11417 110662004410 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662004411 Walker A/P-loop; other site 110662004412 ATP binding site [chemical binding]; other site 110662004413 Q-loop/lid; other site 110662004414 ABC transporter signature motif; other site 110662004415 Walker B; other site 110662004416 H-loop/switch region; other site 110662004417 Protein of unknown function (DUF1997); Region: DUF1997; pfam09366 110662004418 fumarate hydratase; Reviewed; Region: fumC; PRK00485 110662004419 Class II fumarases; Region: Fumarase_classII; cd01362 110662004420 active site 110662004421 tetramer interface [polypeptide binding]; other site 110662004422 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 110662004423 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662004424 ATP binding site [chemical binding]; other site 110662004425 putative Mg++ binding site [ion binding]; other site 110662004426 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662004427 nucleotide binding region [chemical binding]; other site 110662004428 ATP-binding site [chemical binding]; other site 110662004429 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 110662004430 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 110662004431 Membrane transport protein; Region: Mem_trans; cl09117 110662004432 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 110662004433 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662004434 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662004435 catalytic residue [active] 110662004436 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 110662004437 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 110662004438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662004439 S-adenosylmethionine binding site [chemical binding]; other site 110662004440 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: PLN02974 110662004441 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662004442 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 110662004443 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 110662004444 inhibitor-cofactor binding pocket; inhibition site 110662004445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662004446 catalytic residue [active] 110662004447 Protein of unknown function (DUF3143); Region: DUF3143; pfam11341 110662004448 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 110662004449 HSP70 interaction site [polypeptide binding]; other site 110662004450 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 110662004451 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662004452 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 110662004453 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 110662004454 active site 110662004455 catalytic tetrad [active] 110662004456 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 110662004457 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 110662004458 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 110662004459 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 110662004460 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 110662004461 Sodium:solute symporter family; Region: SSF; cl00456 110662004462 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457 110662004463 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662004464 FeS/SAM binding site; other site 110662004465 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 110662004466 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 110662004467 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 110662004468 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 110662004469 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 110662004470 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 110662004471 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 110662004472 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 110662004473 DNA binding site [nucleotide binding] 110662004474 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 110662004475 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 110662004476 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 110662004477 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 110662004478 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 110662004479 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 110662004480 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 110662004481 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 110662004482 RPB1 interaction site [polypeptide binding]; other site 110662004483 RPB10 interaction site [polypeptide binding]; other site 110662004484 RPB11 interaction site [polypeptide binding]; other site 110662004485 RPB3 interaction site [polypeptide binding]; other site 110662004486 RPB12 interaction site [polypeptide binding]; other site 110662004487 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 110662004488 active site 110662004489 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 110662004490 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 110662004491 histidinol dehydrogenase; Region: hisD; TIGR00069 110662004492 NAD binding site [chemical binding]; other site 110662004493 dimerization interface [polypeptide binding]; other site 110662004494 product binding site; other site 110662004495 substrate binding site [chemical binding]; other site 110662004496 zinc binding site [ion binding]; other site 110662004497 catalytic residues [active] 110662004498 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 110662004499 tetramer (dimer of dimers) interface [polypeptide binding]; other site 110662004500 active site 110662004501 dimer interface [polypeptide binding]; other site 110662004502 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 110662004503 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 110662004504 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 110662004505 protein binding site [polypeptide binding]; other site 110662004506 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 110662004507 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 110662004508 substrate binding pocket [chemical binding]; other site 110662004509 membrane-bound complex binding site; other site 110662004510 hinge residues; other site 110662004511 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662004512 FeS/SAM binding site; other site 110662004513 ribosome maturation protein RimP; Reviewed; Region: PRK00092 110662004514 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 110662004515 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 110662004516 Sm1 motif; other site 110662004517 D3 - B interaction site; other site 110662004518 RNA binding pocket [nucleotide binding]; other site 110662004519 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 110662004520 NusA N-terminal domain; Region: NusA_N; pfam08529 110662004521 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 110662004522 RNA binding site [nucleotide binding]; other site 110662004523 homodimer interface [polypeptide binding]; other site 110662004524 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 110662004525 G-X-X-G motif; other site 110662004526 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 110662004527 putative RNA binding cleft [nucleotide binding]; other site 110662004528 translation initiation factor IF-2; Region: IF-2; TIGR00487 110662004529 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 110662004530 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 110662004531 G1 box; other site 110662004532 putative GEF interaction site [polypeptide binding]; other site 110662004533 GTP/Mg2+ binding site [chemical binding]; other site 110662004534 Switch I region; other site 110662004535 G2 box; other site 110662004536 G3 box; other site 110662004537 Switch II region; other site 110662004538 G4 box; other site 110662004539 G5 box; other site 110662004540 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 110662004541 Translation-initiation factor 2; Region: IF-2; pfam11987 110662004542 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 110662004543 Transcription initiation factor IIF, alpha subunit, N-terminal region of RAP74. Subunit of transcription initiation complex involved in initiation, elongation and promoter escape.Tetramer of 2 alpha and 2 beta TFIIF subunits interacts directly with RNA...; Region: TFIIFa; cl15395 110662004544 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 110662004545 Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498 110662004546 putative Iron-sulfur protein interface [polypeptide binding]; other site 110662004547 proximal heme binding site [chemical binding]; other site 110662004548 distal heme binding site [chemical binding]; other site 110662004549 putative dimer interface [polypeptide binding]; other site 110662004550 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573 110662004551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004552 domain; Region: Succ_DH_flav_C; pfam02910 110662004553 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570 110662004554 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 110662004555 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 110662004556 active site 110662004557 HIGH motif; other site 110662004558 KMSKS motif; other site 110662004559 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 110662004560 IHF dimer interface [polypeptide binding]; other site 110662004561 IHF - DNA interface [nucleotide binding]; other site 110662004562 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662004563 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 110662004564 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 110662004565 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 110662004566 active site 110662004567 catalytic site [active] 110662004568 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 110662004569 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 110662004570 Domain of unknown function DUF140; Region: DUF140; cl00510 110662004571 Protein of unknown function (DUF3119); Region: DUF3119; pfam11317 110662004572 Protein of unknown function (DUF3086); Region: DUF3086; pfam11285 110662004573 Domain of unknown function (DUF205); Region: DUF205; cl00410 110662004574 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 110662004575 active site 110662004576 dimer interface [polypeptide binding]; other site 110662004577 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 110662004578 putative active site [active] 110662004579 putative substrate binding site [chemical binding]; other site 110662004580 ATP binding site [chemical binding]; other site 110662004581 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 110662004582 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 110662004583 active site 110662004584 HIGH motif; other site 110662004585 dimer interface [polypeptide binding]; other site 110662004586 KMSKS motif; other site 110662004587 Domain of unknown function (DUF1825); Region: DUF1825; pfam08855 110662004588 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 110662004589 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 110662004590 phosphorylation site [posttranslational modification] 110662004591 intermolecular recognition site; other site 110662004592 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 110662004593 DNA binding residues [nucleotide binding] 110662004594 dimerization interface [polypeptide binding]; other site 110662004595 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 110662004596 multifunctional aminopeptidase A; Provisional; Region: PRK00913 110662004597 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 110662004598 interface (dimer of trimers) [polypeptide binding]; other site 110662004599 Substrate-binding/catalytic site; other site 110662004600 Zn-binding sites [ion binding]; other site 110662004601 Domain of unknown function (DUF4278); Region: DUF4278; pfam14105 110662004602 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 110662004603 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 110662004604 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 110662004605 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662004606 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 110662004607 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 110662004608 active site 110662004609 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 110662004610 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 110662004611 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 110662004612 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 110662004613 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 110662004614 Surface antigen; Region: Bac_surface_Ag; cl03097 110662004615 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 110662004616 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 110662004617 ATP binding site [chemical binding]; other site 110662004618 active site 110662004619 substrate binding site [chemical binding]; other site 110662004620 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 110662004621 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 110662004622 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662004623 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 110662004624 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 110662004625 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 110662004626 dimerization interface [polypeptide binding]; other site 110662004627 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 110662004628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 110662004629 dimer interface [polypeptide binding]; other site 110662004630 phosphorylation site [posttranslational modification] 110662004631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 110662004632 ATP binding site [chemical binding]; other site 110662004633 Mg2+ binding site [ion binding]; other site 110662004634 G-X-G motif; other site 110662004635 circadian clock protein KaiC; Region: circ_KaiC; TIGR02655 110662004636 KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124 110662004637 Walker A motif; other site 110662004638 ATP binding site [chemical binding]; other site 110662004639 Walker B motif; other site 110662004640 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662004641 Walker A motif; other site 110662004642 ATP binding site [chemical binding]; other site 110662004643 Walker B motif; other site 110662004644 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 110662004645 tetramer interface [polypeptide binding]; other site 110662004646 dimer interface [polypeptide binding]; other site 110662004647 KaiA domain; Region: KaiA; pfam07688 110662004648 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 110662004649 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 110662004650 Predicted membrane protein (DUF2127); Region: DUF2127; cl01785 110662004651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662004652 S-adenosylmethionine binding site [chemical binding]; other site 110662004653 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755 110662004654 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 110662004655 RNA binding site [nucleotide binding]; other site 110662004656 active site 110662004657 Domain of unknown function DUF28; Region: DUF28; cl00361 110662004658 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; cl12088 110662004659 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 110662004660 RecA-family ATPase [DNA replication, recombination, and repair]; Region: RepA; COG3598 110662004661 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662004662 Walker A motif; other site 110662004663 ATP binding site [chemical binding]; other site 110662004664 Walker B motif; other site 110662004665 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 110662004666 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 110662004667 active site 110662004668 trimer interface [polypeptide binding]; other site 110662004669 allosteric site; other site 110662004670 active site lid [active] 110662004671 hexamer (dimer of trimers) interface [polypeptide binding]; other site 110662004672 Stage II sporulation protein; Region: SpoIID; pfam08486 110662004673 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 110662004674 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662004675 Cytochrome c; Region: Cytochrom_C; cl11414 110662004676 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 110662004677 catalytic loop [active] 110662004678 iron binding site [ion binding]; other site 110662004679 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 110662004680 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 110662004681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004682 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 110662004683 putative L-serine binding site [chemical binding]; other site 110662004684 photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069 110662004685 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 110662004686 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705 110662004687 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 110662004688 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 110662004689 EVE domain; Region: EVE; cl00728 110662004690 Protein of unknown function (DUF2811); Region: DUF2811; pfam10929 110662004691 Domain of unknown function (DUF1818); Region: DUF1818; pfam08848 110662004692 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 110662004693 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 110662004694 Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941 110662004695 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 110662004696 Sulfatase; Region: Sulfatase; cl10460 110662004697 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 110662004698 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 110662004699 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 110662004700 ring oligomerisation interface [polypeptide binding]; other site 110662004701 ATP/Mg binding site [chemical binding]; other site 110662004702 stacking interactions; other site 110662004703 hinge regions; other site 110662004704 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 110662004705 oligomerisation interface [polypeptide binding]; other site 110662004706 mobile loop; other site 110662004707 roof hairpin; other site 110662004708 ATP synthase CF1 beta subunit; Region: atpB; CHL00060 110662004709 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 110662004710 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 110662004711 alpha subunit interaction interface [polypeptide binding]; other site 110662004712 Walker A motif; other site 110662004713 ATP binding site [chemical binding]; other site 110662004714 Walker B motif; other site 110662004715 inhibitor binding site; inhibition site 110662004716 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 110662004717 ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063 110662004718 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 110662004719 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 110662004720 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793 110662004721 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 110662004722 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 110662004723 Ca2+/H+ antiporter [Inorganic ion transport and metabolism]; Region: ChaA; COG0387 110662004724 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 110662004725 Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433 110662004726 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 110662004727 active site 110662004728 Domain of unknown function DUF21; Region: DUF21; pfam01595 110662004729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 110662004730 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 110662004731 G1 box; other site 110662004732 GTP/Mg2+ binding site [chemical binding]; other site 110662004733 Switch I region; other site 110662004734 G2 box; other site 110662004735 Switch II region; other site 110662004736 G3 box; other site 110662004737 G4 box; other site 110662004738 G5 box; other site 110662004739 Domain of unknown function (DUF697); Region: DUF697; cl12064 110662004740 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 110662004741 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 110662004742 active site 110662004743 (T/H)XGH motif; other site 110662004744 NAD synthetase; Provisional; Region: PRK13981 110662004745 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 110662004746 multimer interface [polypeptide binding]; other site 110662004747 active site 110662004748 catalytic triad [active] 110662004749 protein interface 1 [polypeptide binding]; other site 110662004750 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 110662004751 homodimer interface [polypeptide binding]; other site 110662004752 NAD binding pocket [chemical binding]; other site 110662004753 ATP binding pocket [chemical binding]; other site 110662004754 Mg binding site [ion binding]; other site 110662004755 active-site loop [active] 110662004756 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 110662004757 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 110662004758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004759 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3012 110662004760 SEC-C motif; Region: SEC-C; pfam02810 110662004761 Protein of unknown function (DUF3326); Region: DUF3326; pfam11805 110662004762 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 110662004763 catalytic loop [active] 110662004764 iron binding site [ion binding]; other site 110662004765 conserved hypothetical protein; Region: TIGR02466 110662004766 NADH:ubiquinone oxidoreductase 27 kD subunit [Energy production and conversion]; Region: NuoC; cl00365 110662004767 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 110662004768 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 110662004769 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 110662004770 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 110662004771 beta subunit interaction interface [polypeptide binding]; other site 110662004772 Walker A motif; other site 110662004773 ATP binding site [chemical binding]; other site 110662004774 Walker B motif; other site 110662004775 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 110662004776 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 110662004777 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 110662004778 F0F1 ATP synthase subunit B; Validated; Region: PRK07352 110662004779 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 110662004780 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 110662004781 ATP synthase subunit C; Region: ATP-synt_C; cl00466 110662004782 ATP synthase A chain; Region: ATP-synt_A; cl00413 110662004783 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662004784 S-adenosylmethionine binding site [chemical binding]; other site 110662004785 phycobillisome linker protein; Region: apcE; CHL00091 110662004786 Phycobilisome protein; Region: Phycobilisome; cl08227 110662004787 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662004788 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662004789 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662004790 Phycobilisome protein; Region: Phycobilisome; cl08227 110662004791 Phycobilisome protein; Region: Phycobilisome; cl08227 110662004792 CpcD/allophycocyanin linker domain; Region: CpcD; cl03191 110662004793 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 110662004794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 110662004795 RNA binding surface [nucleotide binding]; other site 110662004796 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662004797 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 110662004798 LysE type translocator; Region: LysE; cl00565 110662004799 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 110662004800 ResB-like family; Region: ResB; pfam05140 110662004801 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 110662004802 Nitrogen regulatory protein P-II; Region: P-II; cl00412 110662004803 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 110662004804 adenylosuccinate lyase; Provisional; Region: PRK07380 110662004805 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 110662004806 tetramer interface [polypeptide binding]; other site 110662004807 active site 110662004808 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 110662004809 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 110662004810 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 110662004811 SLBB domain; Region: SLBB; pfam10531 110662004812 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662004813 Phosphopantetheine attachment site; Region: PP-binding; cl09936 110662004814 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 110662004815 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 110662004816 dimer interface [polypeptide binding]; other site 110662004817 active site 110662004818 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662004819 putative acyl-acceptor binding pocket; other site 110662004820 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 110662004821 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 110662004822 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 110662004823 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 110662004824 ligand binding site; other site 110662004825 tetramer interface; other site 110662004826 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607 110662004827 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 110662004828 NeuB family; Region: NeuB; cl00496 110662004829 SAF domain; Region: SAF; cl00555 110662004830 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 110662004831 Sulfotransferase family; Region: Sulfotransfer_2; cl12149 110662004832 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 110662004833 NAD(P) binding site [chemical binding]; other site 110662004834 putative active site [active] 110662004835 Nitrogen fixation protein of unknown function; Region: Nif11; cl06756 110662004836 Protein of unknown function (DUF2808); Region: DUF2808; pfam10989 110662004837 Protein of unknown function (DUF3750); Region: DUF3750; pfam12570 110662004838 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 110662004839 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662004840 Int/Topo IB signature motif; other site 110662004841 active site 110662004842 catalytic residues [active] 110662004843 DNA binding site [nucleotide binding] 110662004844 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 110662004845 ligand binding site [chemical binding]; other site 110662004846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 110662004847 DNA binding site [nucleotide binding] 110662004848 Int/Topo IB signature motif; other site 110662004849 active site 110662004850 hypothetical protein; Validated; Region: PRK07078 110662004851 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 110662004852 ligand binding site; other site 110662004853 tetramer interface; other site 110662004854 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 110662004855 THUMP domain; Region: THUMP; cl12076 110662004856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662004857 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 110662004858 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 110662004859 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 110662004860 Walker A/P-loop; other site 110662004861 ATP binding site [chemical binding]; other site 110662004862 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 110662004863 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 110662004864 Q-loop/lid; other site 110662004865 ABC transporter signature motif; other site 110662004866 Walker B; other site 110662004867 D-loop; other site 110662004868 H-loop/switch region; other site 110662004869 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 110662004870 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 110662004871 SelR domain; Region: SelR; cl00369 110662004872 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 110662004873 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 110662004874 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 110662004875 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662004876 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 110662004877 YGGT family; Region: YGGT; cl00508 110662004878 Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887 110662004879 Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444 110662004880 translocation protein TolB; Provisional; Region: tolB; PRK02889 110662004881 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 110662004882 Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879 110662004883 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662004884 Peroxisomal ATP-binding cassette transporter (Pat) is involved in the import of very long-chain fatty acids (VLCFA) into the peroxisome. The peroxisomal membrane forms a permeability barrier for a wide variety of metabolites required for and formed...; Region: ABCD_peroxisomal_ALDP; cd03223 110662004885 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 110662004886 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 110662004887 nucleotide binding site/active site [active] 110662004888 HIT family signature motif; other site 110662004889 catalytic residue [active] 110662004890 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 110662004891 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 110662004892 active site 110662004893 catalytic residues [active] 110662004894 metal binding site [ion binding]; metal-binding site 110662004895 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 110662004896 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662004897 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 110662004898 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662004899 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 110662004900 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 110662004901 Aminotransferase class-V; Region: Aminotran_5; pfam00266 110662004902 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662004903 catalytic residue [active] 110662004904 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 110662004905 FeS assembly ATPase SufC; Region: sufC; TIGR01978 110662004906 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 110662004907 Walker A/P-loop; other site 110662004908 ATP binding site [chemical binding]; other site 110662004909 Q-loop/lid; other site 110662004910 ABC transporter signature motif; other site 110662004911 Walker B; other site 110662004912 D-loop; other site 110662004913 H-loop/switch region; other site 110662004914 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 110662004915 putative ABC transporter; Region: ycf24; CHL00085 110662004916 Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977 110662004917 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 110662004918 Helix-turn-helix domains; Region: HTH; cl00088 110662004919 CpeS-like protein; Region: CpeS; pfam09367 110662004920 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662004921 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 110662004922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 110662004923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662004924 binding surface 110662004925 TPR motif; other site 110662004926 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 110662004927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662004928 S-adenosylmethionine binding site [chemical binding]; other site 110662004929 phosphoglucomutase; Region: PLN02307 110662004930 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 110662004931 active site 110662004932 substrate binding site [chemical binding]; other site 110662004933 metal binding site [ion binding]; metal-binding site 110662004934 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cl02586 110662004935 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 110662004936 Protein export membrane protein; Region: SecD_SecF; cl14618 110662004937 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 110662004938 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 110662004939 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 110662004940 lipoyl-biotinyl attachment site [posttranslational modification]; other site 110662004941 recombination factor protein RarA/unknown domain fusion protein; Reviewed; Region: PRK13341 110662004942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662004943 Walker A motif; other site 110662004944 ATP binding site [chemical binding]; other site 110662004945 Walker B motif; other site 110662004946 arginine finger; other site 110662004947 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 110662004948 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 110662004949 catalytic triad [active] 110662004950 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 110662004951 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 110662004952 Active Sites [active] 110662004953 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 110662004954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004955 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 110662004956 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 110662004957 G1 box; other site 110662004958 GTP/Mg2+ binding site [chemical binding]; other site 110662004959 Switch I region; other site 110662004960 G2 box; other site 110662004961 G3 box; other site 110662004962 Switch II region; other site 110662004963 G4 box; other site 110662004964 G5 box; other site 110662004965 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 110662004966 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 110662004967 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 110662004968 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 110662004969 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 110662004970 Cation transport protein; Region: TrkH; cl10514 110662004971 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 110662004972 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662004973 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 110662004974 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 110662004975 Protein of unknown function (DUF1662); Region: DUF1662; pfam07878 110662004976 Protein of unknown function (DUF1525); Region: DUF1525; cl06515 110662004977 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 110662004978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662004979 Walker A/P-loop; other site 110662004980 ATP binding site [chemical binding]; other site 110662004981 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662004982 Q-loop/lid; other site 110662004983 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 110662004984 ABC transporter; Region: ABC_tran_2; pfam12848 110662004985 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 110662004986 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 110662004987 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 110662004988 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 110662004989 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 110662004990 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662004991 ATP binding site [chemical binding]; other site 110662004992 putative Mg++ binding site [ion binding]; other site 110662004993 Helicase associated domain (HA2); Region: HA2; cl04503 110662004994 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 110662004995 putative high light inducible protein; Region: PHA02337 110662004996 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 110662004997 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 110662004998 generic binding surface II; other site 110662004999 generic binding surface I; other site 110662005000 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 110662005001 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 110662005002 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 110662005003 Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643 110662005004 active site 110662005005 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 110662005006 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 110662005007 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 110662005008 Protein of unknown function (DUF512); Region: DUF512; pfam04459 110662005009 Bacitracin resistance protein BacA; Region: BacA; cl00858 110662005010 Protein of unknown function (DUF3120); Region: DUF3120; pfam11318 110662005011 photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515 110662005012 L-aspartate oxidase; Provisional; Region: PRK07395 110662005013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005014 Vitamin K epoxide reductase family; Region: VKOR; cl01729 110662005015 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 110662005016 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 110662005017 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 110662005018 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662005019 FeS/SAM binding site; other site 110662005020 H+ Antiporter protein; Region: 2A0121; TIGR00900 110662005021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 110662005022 putative substrate translocation pore; other site 110662005023 H+ Antiporter protein; Region: 2A0121; TIGR00900 110662005024 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 110662005025 putative substrate translocation pore; other site 110662005026 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 110662005027 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 110662005028 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662005029 FeS/SAM binding site; other site 110662005030 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 110662005031 FemAB family; Region: FemAB; cl11444 110662005032 Protein of unknown function, DUF482; Region: DUF482; pfam04339 110662005033 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 110662005034 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 110662005035 active site 110662005036 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 110662005037 active site 110662005038 shikimate kinase; Reviewed; Region: aroK; PRK00131 110662005039 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 110662005040 ADP binding site [chemical binding]; other site 110662005041 magnesium binding site [ion binding]; other site 110662005042 putative shikimate binding site; other site 110662005043 Protein of unknown function (DUF3571); Region: DUF3571; pfam12095 110662005044 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 110662005045 C-terminal domain interface [polypeptide binding]; other site 110662005046 GSH binding site (G-site) [chemical binding]; other site 110662005047 dimer interface [polypeptide binding]; other site 110662005048 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 110662005049 N-terminal domain interface [polypeptide binding]; other site 110662005050 Protein of unknown function (DUF751); Region: DUF751; pfam05421 110662005051 Ribosome-binding factor A; Region: RBFA; cl00542 110662005052 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 110662005053 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 110662005054 putative metal binding site; other site 110662005055 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 110662005056 binding surface 110662005057 TPR motif; other site 110662005058 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662005059 binding surface 110662005060 TPR motif; other site 110662005061 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 110662005062 active site 110662005063 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 110662005064 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817 110662005065 putative hydrophobic ligand binding site [chemical binding]; other site 110662005066 Uncharacterized conserved protein [Function unknown]; Region: COG3349 110662005067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005068 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 110662005069 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370 110662005070 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 110662005071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005072 TIGR01777 family protein; Region: yfcH 110662005073 NAD(P) binding site [chemical binding]; other site 110662005074 active site 110662005075 Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910 110662005076 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 110662005077 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 110662005078 HSP70 interaction site [polypeptide binding]; other site 110662005079 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 110662005080 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 110662005081 dimer interface [polypeptide binding]; other site 110662005082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662005083 catalytic residue [active] 110662005084 S-layer homology domain; Region: SLH; pfam00395 110662005085 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 110662005086 S-layer homology domain; Region: SLH; pfam00395 110662005087 Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966 110662005088 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 110662005089 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 110662005090 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 110662005091 Ligand binding site; other site 110662005092 Putative Catalytic site; other site 110662005093 DXD motif; other site 110662005094 GtrA-like protein; Region: GtrA; cl00971 110662005095 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl15364 110662005096 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 110662005097 Predicted membrane protein (DUF2079); Region: DUF2079; cl01374 110662005098 D2 subunit of photosystem II (PS II); Region: Photosystem-II_D2; cd09288 110662005099 D1 interface; other site 110662005100 chlorophyll binding site; other site 110662005101 pheophytin binding site; other site 110662005102 beta carotene binding site; other site 110662005103 cytochrome b559 beta interface; other site 110662005104 quinone binding site; other site 110662005105 cytochrome b559 alpha interface; other site 110662005106 protein J interface; other site 110662005107 protein H interface; other site 110662005108 protein X interface; other site 110662005109 core light harvesting protein interface; other site 110662005110 protein L interface; other site 110662005111 CP43 interface; other site 110662005112 protein T interface; other site 110662005113 Fe binding site [ion binding]; other site 110662005114 protein M interface; other site 110662005115 Mn-stabilizing polypeptide interface; other site 110662005116 bromide binding site; other site 110662005117 cytochrome c-550 interface; other site 110662005118 hypothetical protein; Provisional; Region: PRK13683 110662005119 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 110662005120 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662005121 Walker A/P-loop; other site 110662005122 ATP binding site [chemical binding]; other site 110662005123 Q-loop/lid; other site 110662005124 ABC transporter signature motif; other site 110662005125 Walker B; other site 110662005126 D-loop; other site 110662005127 H-loop/switch region; other site 110662005128 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 110662005129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662005130 active site 110662005131 phosphorylation site [posttranslational modification] 110662005132 intermolecular recognition site; other site 110662005133 dimerization interface [polypeptide binding]; other site 110662005134 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662005135 DNA binding site [nucleotide binding] 110662005136 DNA polymerase III subunit delta'; Validated; Region: PRK07399 110662005137 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 110662005138 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 110662005139 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 110662005140 TMP-binding site; other site 110662005141 ATP-binding site [chemical binding]; other site 110662005142 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 110662005143 metal-binding site [ion binding] 110662005144 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 110662005145 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 110662005146 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 110662005147 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 110662005148 binding surface 110662005149 TPR motif; other site 110662005150 DNA repair protein RadA; Provisional; Region: PRK11823 110662005151 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662005152 Walker A motif; other site 110662005153 ATP binding site [chemical binding]; other site 110662005154 Walker B motif; other site 110662005155 Ycf27; Reviewed; Region: orf27; CHL00148 110662005156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662005157 active site 110662005158 phosphorylation site [posttranslational modification] 110662005159 intermolecular recognition site; other site 110662005160 dimerization interface [polypeptide binding]; other site 110662005161 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 110662005162 DNA binding site [nucleotide binding] 110662005163 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 110662005164 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 110662005165 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 110662005166 dimer interface [polypeptide binding]; other site 110662005167 active site 110662005168 CoA binding pocket [chemical binding]; other site 110662005169 Acyl transferase domain; Region: Acyl_transf_1; cl08282 110662005170 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 110662005171 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 110662005172 putative acyl-acceptor binding pocket; other site 110662005173 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 110662005174 putative active site [active] 110662005175 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 110662005176 Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718 110662005177 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 110662005178 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 110662005179 active site 110662005180 NTP binding site [chemical binding]; other site 110662005181 metal binding triad [ion binding]; metal-binding site 110662005182 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 110662005183 RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590 110662005184 RNA/DNA binding site [nucleotide binding]; other site 110662005185 RRM dimerization site [polypeptide binding]; other site 110662005186 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 110662005187 active site lid residues [active] 110662005188 substrate binding pocket [chemical binding]; other site 110662005189 catalytic residues [active] 110662005190 substrate-Mg2+ binding site; other site 110662005191 aspartate-rich region 1; other site 110662005192 aspartate-rich region 2; other site 110662005193 Uncharacterized conserved protein [Function unknown]; Region: COG3349 110662005194 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005195 Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664 110662005196 Protein of unknown function (DUF3172); Region: DUF3172; pfam11371 110662005197 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 110662005198 Helix-turn-helix domains; Region: HTH; cl00088 110662005199 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 110662005200 putative dimerization interface [polypeptide binding]; other site 110662005201 Isoprenylcysteine carboxyl methyltransferase (ICMT) family; Region: ICMT; cl00763 110662005202 NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376 110662005203 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 110662005204 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 110662005205 NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546 110662005206 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 110662005207 ScpA/B protein; Region: ScpA_ScpB; cl00598 110662005208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 110662005209 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 110662005210 active site 110662005211 Substrate binding site; other site 110662005212 Mg++ binding site; other site 110662005213 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 110662005214 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 110662005215 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 110662005216 FAD binding site [chemical binding]; other site 110662005217 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 110662005218 DNA binding residues [nucleotide binding] 110662005219 dimerization interface [polypeptide binding]; other site 110662005220 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 110662005221 putative active site [active] 110662005222 putative metal binding residues [ion binding]; other site 110662005223 signature motif; other site 110662005224 putative dimer interface [polypeptide binding]; other site 110662005225 putative phosphate binding site [ion binding]; other site 110662005226 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 110662005227 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 110662005228 NADH dehydrogenase subunit 6; Region: ndhG; CHL00016 110662005229 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 110662005230 NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403 110662005231 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 110662005232 NADH dehydrogenase; Region: NADHdh; cl00469 110662005233 citrate synthase; Provisional; Region: PRK14036 110662005234 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 110662005235 oxalacetate binding site [chemical binding]; other site 110662005236 citrylCoA binding site [chemical binding]; other site 110662005237 coenzyme A binding site [chemical binding]; other site 110662005238 catalytic triad [active] 110662005239 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 110662005240 catalytic core [active] 110662005241 Protein of unknown function (DUF3352); Region: DUF3352; pfam11832 110662005242 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 110662005243 active site residue [active] 110662005244 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 110662005245 HrcA protein C terminal domain; Region: HrcA; pfam01628 110662005246 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 110662005247 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 110662005248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662005249 catalytic residue [active] 110662005250 The SUI1/eIF1 (eukaryotic initiation factor 1) fold is found in eukaryotes, archaea, and some bacteria and is thought to play an important role in accurate initiator codon recognition during translation initiation. This fold, which includes two...; Region: SUI1_eIF1; cl00229 110662005251 putative binding site; other site 110662005252 Mutations affecting start-site selection; other site 110662005253 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 110662005254 Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265 110662005255 ligand-binding site [chemical binding]; other site 110662005256 Domain of unknown function DUF20; Region: UPF0118; cl00465 110662005257 AIR carboxylase; Region: AIRC; cl00310 110662005258 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 110662005259 active site 110662005260 Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580 110662005261 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662005262 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662005263 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 110662005264 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 110662005265 active site 110662005266 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 110662005267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 110662005268 active site 110662005269 phosphorylation site [posttranslational modification] 110662005270 intermolecular recognition site; other site 110662005271 dimerization interface [polypeptide binding]; other site 110662005272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 110662005273 DNA binding residues [nucleotide binding] 110662005274 dimerization interface [polypeptide binding]; other site 110662005275 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 110662005276 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662005277 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662005278 catalytic residue [active] 110662005279 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 110662005280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662005281 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 110662005282 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 110662005283 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 110662005284 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 110662005285 active site 110662005286 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 110662005287 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 110662005288 active site 110662005289 UbiA prenyltransferase family; Region: UbiA; cl00337 110662005290 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 110662005291 chorismate binding enzyme; Region: Chorismate_bind; cl10555 110662005292 glutathione synthetase; Provisional; Region: PRK05246 110662005293 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 110662005294 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662005295 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 110662005296 GSH binding site [chemical binding]; other site 110662005297 catalytic residues [active] 110662005298 peptide chain release factor 2; Validated; Region: prfB; PRK00578 110662005299 RF-1 domain; Region: RF-1; cl02875 110662005300 RF-1 domain; Region: RF-1; cl02875 110662005301 Protein of unknown function (DUF3285); Region: DUF3285; pfam11688 110662005302 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 110662005303 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 110662005304 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 110662005305 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 110662005306 glutamine binding [chemical binding]; other site 110662005307 catalytic triad [active] 110662005308 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662005309 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 110662005310 active site 110662005311 homotetramer interface [polypeptide binding]; other site 110662005312 homodimer interface [polypeptide binding]; other site 110662005313 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 110662005314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 110662005315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662005316 homodimer interface [polypeptide binding]; other site 110662005317 catalytic residue [active] 110662005318 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 110662005319 arginine-tRNA ligase; Region: PLN02286 110662005320 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 110662005321 active site 110662005322 HIGH motif; other site 110662005323 KMSK motif region; other site 110662005324 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 110662005325 tRNA binding surface [nucleotide binding]; other site 110662005326 anticodon binding site; other site 110662005327 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 110662005328 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 110662005329 dimerization interface [polypeptide binding]; other site 110662005330 active site 110662005331 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 110662005332 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 110662005333 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 110662005334 G1 box; other site 110662005335 GTP/Mg2+ binding site [chemical binding]; other site 110662005336 Switch I region; other site 110662005337 G2 box; other site 110662005338 Switch II region; other site 110662005339 G3 box; other site 110662005340 G4 box; other site 110662005341 G5 box; other site 110662005342 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 110662005343 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 110662005344 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 110662005345 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 110662005346 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 110662005347 synthetase active site [active] 110662005348 NTP binding site [chemical binding]; other site 110662005349 metal binding site [ion binding]; metal-binding site 110662005350 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 110662005351 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 110662005352 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 110662005353 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 110662005354 Walker A/P-loop; other site 110662005355 ATP binding site [chemical binding]; other site 110662005356 Q-loop/lid; other site 110662005357 ABC transporter signature motif; other site 110662005358 Walker B; other site 110662005359 D-loop; other site 110662005360 H-loop/switch region; other site 110662005361 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 110662005362 Walker A/P-loop; other site 110662005363 ATP binding site [chemical binding]; other site 110662005364 Q-loop/lid; other site 110662005365 ABC transporter signature motif; other site 110662005366 Walker B; other site 110662005367 D-loop; other site 110662005368 H-loop/switch region; other site 110662005369 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 110662005370 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 110662005371 RNA binding surface [nucleotide binding]; other site 110662005372 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 110662005373 active site 110662005374 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 110662005375 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 110662005376 GTP/Mg2+ binding site [chemical binding]; other site 110662005377 G4 box; other site 110662005378 G5 box; other site 110662005379 G1 box; other site 110662005380 Switch I region; other site 110662005381 G2 box; other site 110662005382 G3 box; other site 110662005383 Switch II region; other site 110662005384 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 110662005385 Phosphoglycerate kinase; Region: PGK; pfam00162 110662005386 substrate binding site [chemical binding]; other site 110662005387 hinge regions; other site 110662005388 ADP binding site [chemical binding]; other site 110662005389 catalytic site [active] 110662005390 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 110662005391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005392 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 110662005393 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 110662005394 active site 110662005395 homodimer interface [polypeptide binding]; other site 110662005396 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 110662005397 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 110662005398 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662005399 homodimer interface [polypeptide binding]; other site 110662005400 catalytic residue [active] 110662005401 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 110662005402 quinone interaction residues [chemical binding]; other site 110662005403 Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167 110662005404 active site 110662005405 catalytic residues [active] 110662005406 FMN binding site [chemical binding]; other site 110662005407 substrate binding site [chemical binding]; other site 110662005408 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 110662005409 RNA/DNA hybrid binding site [nucleotide binding]; other site 110662005410 active site 110662005411 Protein of unknown function (DUF3747); Region: DUF3747; pfam12565 110662005412 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 110662005413 L11 interface [polypeptide binding]; other site 110662005414 putative EF-Tu interaction site [polypeptide binding]; other site 110662005415 putative EF-G interaction site [polypeptide binding]; other site 110662005416 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 110662005417 23S rRNA interface [nucleotide binding]; other site 110662005418 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 110662005419 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 110662005420 mRNA/rRNA interface [nucleotide binding]; other site 110662005421 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 110662005422 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 110662005423 23S rRNA interface [nucleotide binding]; other site 110662005424 L7/L12 interface [polypeptide binding]; other site 110662005425 putative thiostrepton binding site; other site 110662005426 L25 interface [polypeptide binding]; other site 110662005427 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 110662005428 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 110662005429 putative homodimer interface [polypeptide binding]; other site 110662005430 KOW motif; Region: KOW; cl00354 110662005431 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 110662005432 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 110662005433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662005434 Walker A motif; other site 110662005435 ATP binding site [chemical binding]; other site 110662005436 Walker B motif; other site 110662005437 arginine finger; other site 110662005438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662005439 Walker A motif; other site 110662005440 ATP binding site [chemical binding]; other site 110662005441 Walker B motif; other site 110662005442 arginine finger; other site 110662005443 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 110662005444 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 110662005445 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 110662005446 dimer interface [polypeptide binding]; other site 110662005447 active site 110662005448 metal binding site [ion binding]; metal-binding site 110662005449 glutathione binding site [chemical binding]; other site 110662005450 enolase; Provisional; Region: eno; PRK00077 110662005451 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 110662005452 dimer interface [polypeptide binding]; other site 110662005453 metal binding site [ion binding]; metal-binding site 110662005454 substrate binding pocket [chemical binding]; other site 110662005455 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 110662005456 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 110662005457 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 110662005458 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 110662005459 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 110662005460 active site 110662005461 metal binding site [ion binding]; metal-binding site 110662005462 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 110662005463 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 110662005464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 110662005465 active site 110662005466 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 110662005467 heterotetramer interface [polypeptide binding]; other site 110662005468 active site pocket [active] 110662005469 cleavage site 110662005470 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 110662005471 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 110662005472 CoA-binding site [chemical binding]; other site 110662005473 ATP-binding [chemical binding]; other site 110662005474 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 110662005475 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 110662005476 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 110662005477 GatB domain; Region: GatB_Yqey; cl11497 110662005478 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 110662005479 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005480 bacteriocin-type transport-associated protein; Region: cyc_nuc_ocin; TIGR03896 110662005481 NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797 110662005482 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662005483 Walker A/P-loop; other site 110662005484 ATP binding site [chemical binding]; other site 110662005485 Q-loop/lid; other site 110662005486 ABC transporter signature motif; other site 110662005487 Walker B; other site 110662005488 D-loop; other site 110662005489 H-loop/switch region; other site 110662005490 NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794 110662005491 NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796 110662005492 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cl00296 110662005493 putative active site [active] 110662005494 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662005495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662005496 Walker A/P-loop; other site 110662005497 ATP binding site [chemical binding]; other site 110662005498 Q-loop/lid; other site 110662005499 ABC transporter signature motif; other site 110662005500 Walker B; other site 110662005501 D-loop; other site 110662005502 H-loop/switch region; other site 110662005503 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662005504 S-adenosylmethionine binding site [chemical binding]; other site 110662005505 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 110662005506 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 110662005507 dimer interface [polypeptide binding]; other site 110662005508 active site 110662005509 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 110662005510 catalytic residues [active] 110662005511 substrate binding site [chemical binding]; other site 110662005512 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 110662005513 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662005514 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 110662005515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005516 ATP binding site [chemical binding]; other site 110662005517 substrate interface [chemical binding]; other site 110662005518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662005519 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 110662005520 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 110662005521 active site 110662005522 multimer interface [polypeptide binding]; other site 110662005523 arginine decarboxylase; Provisional; Region: PRK05354 110662005524 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 110662005525 dimer interface [polypeptide binding]; other site 110662005526 active site 110662005527 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 110662005528 catalytic residues [active] 110662005529 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 110662005530 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 110662005531 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 110662005532 ligand binding site [chemical binding]; other site 110662005533 Helix-turn-helix domains; Region: HTH; cl00088 110662005534 CHASE2 domain; Region: CHASE2; cl01732 110662005535 cyclase homology domain; Region: CHD; cd07302 110662005536 nucleotidyl binding site; other site 110662005537 metal binding site [ion binding]; metal-binding site 110662005538 dimer interface [polypeptide binding]; other site 110662005539 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 110662005540 ligand binding site [chemical binding]; other site 110662005541 flexible hinge region; other site 110662005542 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 110662005543 active site 110662005544 dimer interfaces [polypeptide binding]; other site 110662005545 catalytic residues [active] 110662005546 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 110662005547 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 110662005548 motif 1; other site 110662005549 active site 110662005550 motif 2; other site 110662005551 motif 3; other site 110662005552 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 110662005553 SNF2 Helicase protein; Region: DUF3670; pfam12419 110662005554 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 110662005555 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 110662005556 ATP binding site [chemical binding]; other site 110662005557 putative Mg++ binding site [ion binding]; other site 110662005558 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 110662005559 nucleotide binding region [chemical binding]; other site 110662005560 ATP-binding site [chemical binding]; other site 110662005561 MEKHLA domain; Region: MEKHLA; pfam08670 110662005562 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 110662005563 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 110662005564 putative dimer interface [polypeptide binding]; other site 110662005565 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 110662005566 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 110662005567 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 110662005568 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 110662005569 ligand binding site [chemical binding]; other site 110662005570 flexible hinge region; other site 110662005571 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259 110662005572 putative active site [active] 110662005573 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 110662005574 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 110662005575 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 110662005576 Walker A/P-loop; other site 110662005577 ATP binding site [chemical binding]; other site 110662005578 Q-loop/lid; other site 110662005579 ABC transporter signature motif; other site 110662005580 Walker B; other site 110662005581 D-loop; other site 110662005582 H-loop/switch region; other site 110662005583 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 110662005584 PPIC-type PPIASE domain; Region: Rotamase; cl08278 110662005585 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 110662005586 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 110662005587 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662005588 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 110662005589 Flavin Reductases; Region: FlaRed; cl00801 110662005590 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 110662005591 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 110662005592 Flavin Reductases; Region: FlaRed; cl00801 110662005593 Rubrerythrin [Energy production and conversion]; Region: COG1592 110662005594 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 110662005595 binuclear metal center [ion binding]; other site 110662005596 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 110662005597 iron binding site [ion binding]; other site 110662005598 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 110662005599 Pirin-related protein [General function prediction only]; Region: COG1741 110662005600 Cupin domain; Region: Cupin_2; cl09118 110662005601 glycine dehydrogenase; Provisional; Region: PRK05367 110662005602 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662005603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662005604 catalytic residue [active] 110662005605 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 110662005606 tetramer interface [polypeptide binding]; other site 110662005607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662005608 catalytic residue [active] 110662005609 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 110662005610 lipoyl attachment site [posttranslational modification]; other site 110662005611 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 110662005612 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 110662005613 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 110662005614 catalytic residue [active] 110662005615 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 110662005616 Fatty acid desaturase; Region: FA_desaturase; pfam00487 110662005617 Di-iron ligands [ion binding]; other site 110662005618 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 110662005619 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 110662005620 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 110662005621 replicative DNA helicase; Region: DnaB; TIGR00665 110662005622 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 110662005623 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 110662005624 Walker A motif; other site 110662005625 ATP binding site [chemical binding]; other site 110662005626 Walker B motif; other site 110662005627 DNA binding loops [nucleotide binding] 110662005628 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 110662005629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005630 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 110662005631 UTRA domain; Region: UTRA; cl01230 110662005632 SprT homologues; Region: SprT; cl01182 110662005633 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 110662005634 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 110662005635 nucleotide binding pocket [chemical binding]; other site 110662005636 K-X-D-G motif; other site 110662005637 catalytic site [active] 110662005638 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 110662005639 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 110662005640 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 110662005641 Dimer interface [polypeptide binding]; other site 110662005642 BRCT sequence motif; other site 110662005643 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 110662005644 Protein of unknown function (DUF990); Region: DUF990; cl01496 110662005645 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 110662005646 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 110662005647 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662005648 Walker A/P-loop; other site 110662005649 ATP binding site [chemical binding]; other site 110662005650 Q-loop/lid; other site 110662005651 ABC transporter signature motif; other site 110662005652 Walker B; other site 110662005653 D-loop; other site 110662005654 H-loop/switch region; other site 110662005655 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 110662005656 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 110662005657 HIGH motif; other site 110662005658 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 110662005659 active site 110662005660 KMSKS motif; other site 110662005661 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 110662005662 tRNA binding surface [nucleotide binding]; other site 110662005663 anticodon binding site; other site 110662005664 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 110662005665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 110662005666 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 110662005667 Mechanosensitive ion channel; Region: MS_channel; pfam00924 110662005668 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl01206 110662005669 short chain dehydrogenase; Provisional; Region: PRK06197 110662005670 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 110662005671 putative NAD(P) binding site [chemical binding]; other site 110662005672 active site 110662005673 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 110662005674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 110662005675 Walker A motif; other site 110662005676 ATP binding site [chemical binding]; other site 110662005677 Walker B motif; other site 110662005678 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 110662005679 4Fe-4S binding domain; Region: Fer4_5; pfam12801 110662005680 4Fe-4S binding domain; Region: Fer4_5; pfam12801 110662005681 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 110662005682 metal binding site 2 [ion binding]; metal-binding site 110662005683 putative DNA binding helix; other site 110662005684 metal binding site 1 [ion binding]; metal-binding site 110662005685 dimer interface [polypeptide binding]; other site 110662005686 structural Zn2+ binding site [ion binding]; other site 110662005687 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 110662005688 light-harvesting-like protein 3; Provisional; Region: PLN00014 110662005689 conserved hypothetical protein, TIGR03894 family; Region: chp_P_marinus_1 110662005690 Phage integrase family; Region: Phage_integrase; pfam00589 110662005691 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 110662005692 DNA binding site [nucleotide binding] 110662005693 Int/Topo IB signature motif; other site 110662005694 active site 110662005695 catalytic residues [active] 110662005696 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 110662005697 D5 N terminal like; Region: D5_N; cl07360 110662005698 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 110662005699 Poxvirus D5 protein-like; Region: Pox_D5; cl15708 110662005700 light-harvesting-like protein 3; Provisional; Region: PLN00014 110662005701 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 110662005702 Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427 110662005703 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 110662005704 Protein of unknown function (DUF3104); Region: DUF3104; pfam11302 110662005705 Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017 110662005706 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 110662005707 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 110662005708 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 110662005709 RF-1 domain; Region: RF-1; cl02875 110662005710 spermidine synthase; Provisional; Region: PRK00811 110662005711 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 110662005712 S-adenosylmethionine binding site [chemical binding]; other site 110662005713 Arginase family; Region: Arginase; cl00306 110662005714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 110662005715 ligand binding site [chemical binding]; other site 110662005716 flexible hinge region; other site 110662005717 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 110662005718 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 110662005719 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 110662005720 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 110662005721 dimer interface [polypeptide binding]; other site 110662005722 anticodon binding site; other site 110662005723 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 110662005724 homodimer interface [polypeptide binding]; other site 110662005725 motif 1; other site 110662005726 active site 110662005727 motif 2; other site 110662005728 GAD domain; Region: GAD; pfam02938 110662005729 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 110662005730 active site 110662005731 motif 3; other site 110662005732 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 110662005733 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 110662005734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662005735 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 110662005736 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 110662005737 CTP synthetase; Validated; Region: pyrG; PRK05380 110662005738 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 110662005739 Catalytic site [active] 110662005740 active site 110662005741 UTP binding site [chemical binding]; other site 110662005742 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 110662005743 active site 110662005744 putative oxyanion hole; other site 110662005745 catalytic triad [active] 110662005746 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 110662005747 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662005748 FeS/SAM binding site; other site 110662005749 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 110662005750 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 110662005751 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 110662005752 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 110662005753 Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483 110662005754 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 110662005755 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 110662005756 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 110662005757 active site 110662005758 catalytic triad [active] 110662005759 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 110662005760 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005761 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 110662005762 Ligand Binding Site [chemical binding]; other site 110662005763 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 110662005764 aminodeoxychorismate synthase, component I, clade 2; Region: PabB-clade2; TIGR01824 110662005765 chorismate binding enzyme; Region: Chorismate_bind; cl10555 110662005766 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449 110662005767 substrate-cofactor binding pocket; other site 110662005768 homodimer interface [polypeptide binding]; other site 110662005769 Aminotransferase class IV; Region: Aminotran_4; pfam01063 110662005770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662005771 catalytic residue [active] 110662005772 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK00192 110662005773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 110662005774 active site 110662005775 motif I; other site 110662005776 motif II; other site 110662005777 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 110662005778 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 110662005779 sucrose phosphorylase; Provisional; Region: PRK13840 110662005780 active site 110662005781 catalytic site [active] 110662005782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 110662005783 Domain of unknown function (DUF1830); Region: DUF1830; pfam08865 110662005784 Predicted amidohydrolase [General function prediction only]; Region: COG0388 110662005785 aliphatic amidases (class 2 nitrilases); Region: aliphatic_amidase; cd07565 110662005786 multimer interface [polypeptide binding]; other site 110662005787 active site 110662005788 catalytic triad [active] 110662005789 dimer interface [polypeptide binding]; other site 110662005790 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 110662005791 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 110662005792 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 110662005793 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 110662005794 Walker A/P-loop; other site 110662005795 ATP binding site [chemical binding]; other site 110662005796 Q-loop/lid; other site 110662005797 ABC transporter signature motif; other site 110662005798 Walker B; other site 110662005799 D-loop; other site 110662005800 H-loop/switch region; other site 110662005801 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 110662005802 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 110662005803 Walker A/P-loop; other site 110662005804 ATP binding site [chemical binding]; other site 110662005805 Q-loop/lid; other site 110662005806 ABC transporter signature motif; other site 110662005807 Walker B; other site 110662005808 D-loop; other site 110662005809 H-loop/switch region; other site 110662005810 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 110662005811 TM-ABC transporter signature motif; other site 110662005812 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 110662005813 TM-ABC transporter signature motif; other site 110662005814 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 110662005815 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 110662005816 putative ligand binding site [chemical binding]; other site 110662005817 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 110662005818 GTPase Era; Reviewed; Region: era; PRK00089 110662005819 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 110662005820 UreF; Region: UreF; pfam01730 110662005821 urease accessory protein UreE; Provisional; Region: ureE; PRK13261 110662005822 UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571 110662005823 dimer interface [polypeptide binding]; other site 110662005824 catalytic residues [active] 110662005825 UreD urease accessory protein; Region: UreD; cl00530 110662005826 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 110662005827 alpha-gamma subunit interface [polypeptide binding]; other site 110662005828 beta-gamma subunit interface [polypeptide binding]; other site 110662005829 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 110662005830 alpha-beta subunit interface [polypeptide binding]; other site 110662005831 urease subunit alpha; Reviewed; Region: ureC; PRK13207 110662005832 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 110662005833 subunit interactions [polypeptide binding]; other site 110662005834 active site 110662005835 flap region; other site 110662005836 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 110662005837 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 110662005838 catalytic triad [active] 110662005839 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 110662005840 allantoate amidohydrolase; Reviewed; Region: PRK09290 110662005841 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 110662005842 active site 110662005843 metal binding site [ion binding]; metal-binding site 110662005844 dimer interface [polypeptide binding]; other site 110662005845 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 110662005846 active site 110662005847 dimer interface [polypeptide binding]; other site 110662005848 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 110662005849 Ligand Binding Site [chemical binding]; other site 110662005850 Molecular Tunnel; other site 110662005851 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 110662005852 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 110662005853 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 110662005854 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005855 Sodium:solute symporter family; Region: SSF; cl00456 110662005856 Uncharacterized conserved protein [Function unknown]; Region: COG2308 110662005857 Domain of unknown function (DUF404); Region: DUF404; pfam04169 110662005858 Domain of unknown function (DUF407); Region: DUF407; pfam04174 110662005859 Bacterial domain of unknown function (DUF403); Region: DUF403; cl00980 110662005860 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 110662005861 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 110662005862 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 110662005863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 110662005864 FeS/SAM binding site; other site 110662005865 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 110662005866 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 110662005867 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 110662005868 GTP binding site; other site 110662005869 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 110662005870 D-galactonate transporter; Region: 2A0114; TIGR00893 110662005871 putative substrate translocation pore; other site 110662005872 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 110662005873 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 110662005874 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 110662005875 [4Fe-4S] binding site [ion binding]; other site 110662005876 molybdopterin cofactor binding site; other site 110662005877 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 110662005878 molybdopterin cofactor binding site; other site 110662005879 Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869 110662005880 carbonic anhydrase; Provisional; Region: PRK15219 110662005881 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 110662005882 active site clefts [active] 110662005883 zinc binding site [ion binding]; other site 110662005884 dimer interface [polypeptide binding]; other site 110662005885 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 110662005886 trimer interface [polypeptide binding]; other site 110662005887 dimer interface [polypeptide binding]; other site 110662005888 putative active site [active] 110662005889 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 110662005890 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 110662005891 dimer interface [polypeptide binding]; other site 110662005892 putative functional site; other site 110662005893 putative MPT binding site; other site 110662005894 Domain of unknown function (DUF3598); Region: DUF3598; pfam12204 110662005895 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005896 NAD(P) binding site [chemical binding]; other site 110662005897 active site 110662005898 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 110662005899 MoaE homodimer interface [polypeptide binding]; other site 110662005900 MoaD interaction [polypeptide binding]; other site 110662005901 active site residues [active] 110662005902 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 110662005903 MPT binding site; other site 110662005904 trimer interface [polypeptide binding]; other site 110662005905 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 110662005906 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 110662005907 active site 110662005908 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 110662005909 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 110662005910 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 110662005911 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 110662005912 HEAT repeats; Region: HEAT_2; pfam13646 110662005913 cyanate hydratase; Validated; Region: PRK02866 110662005914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 110662005915 non-specific DNA binding site [nucleotide binding]; other site 110662005916 salt bridge; other site 110662005917 sequence-specific DNA binding site [nucleotide binding]; other site 110662005918 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 110662005919 oligomer interface [polypeptide binding]; other site 110662005920 active site 110662005921 hypothetical protein; Provisional; Region: PRK07394 110662005922 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 110662005923 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 110662005924 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 110662005925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 110662005926 polyphosphate kinase; Provisional; Region: PRK05443 110662005927 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 110662005928 putative domain interface [polypeptide binding]; other site 110662005929 putative active site [active] 110662005930 catalytic site [active] 110662005931 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 110662005932 putative domain interface [polypeptide binding]; other site 110662005933 putative active site [active] 110662005934 catalytic site [active] 110662005935 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 110662005936 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 110662005937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 110662005938 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 110662005939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 110662005940 DNA binding residues [nucleotide binding] 110662005941 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 110662005942 NeuB family; Region: NeuB; cl00496 110662005943 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 110662005944 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 110662005945 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 110662005946 substrate binding site [chemical binding]; other site 110662005947 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 110662005948 substrate binding site [chemical binding]; other site 110662005949 ligand binding site [chemical binding]; other site 110662005950 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 110662005951 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 110662005952 Cl- selectivity filter; other site 110662005953 Cl- binding residues [ion binding]; other site 110662005954 pore gating glutamate residue; other site 110662005955 dimer interface [polypeptide binding]; other site 110662005956 H+/Cl- coupling transport residue; other site 110662005957 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 110662005958 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 110662005959 B12 binding site [chemical binding]; other site 110662005960 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 110662005961 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 110662005962 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 110662005963 putative active site [active] 110662005964 putative substrate binding site [chemical binding]; other site 110662005965 putative cosubstrate binding site; other site 110662005966 catalytic site [active] 110662005967 Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363 110662005968 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 110662005969 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005970 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 110662005971 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 110662005972 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 110662005973 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 110662005974 shikimate binding site; other site 110662005975 NAD(P) binding site [chemical binding]; other site 110662005976 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 110662005977 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 110662005978 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 110662005979 ANP binding site [chemical binding]; other site 110662005980 Substrate Binding Site II [chemical binding]; other site 110662005981 Substrate Binding Site I [chemical binding]; other site 110662005982 Protein of unknown function (DUF3134); Region: DUF3134; pfam11332 110662005983 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 110662005984 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 110662005985 Mg++ binding site [ion binding]; other site 110662005986 putative catalytic motif [active] 110662005987 putative substrate binding site [chemical binding]; other site 110662005988 Peptidase family M23; Region: Peptidase_M23; pfam01551 110662005989 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 110662005990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 110662005991 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 110662005992 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 110662005993 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 110662005994 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 110662005995 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 110662005996 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 110662005997 putative ADP-binding pocket [chemical binding]; other site 110662005998 sucrose phosphate synthase, sucrose phosphatase-like domain, bacterial; Region: sucr_syn_bact_C; TIGR02471 110662005999 Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188 110662006000 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 110662006001 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 110662006002 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 110662006003 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 110662006004 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 110662006005 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 110662006006 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 110662006007 Walker A/P-loop; other site 110662006008 ATP binding site [chemical binding]; other site 110662006009 Q-loop/lid; other site 110662006010 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 110662006011 ABC transporter signature motif; other site 110662006012 Walker B; other site 110662006013 D-loop; other site 110662006014 H-loop/switch region; other site 110662006015 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 110662006016 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 110662006017 active site 110662006018 substrate binding site [chemical binding]; other site 110662006019 ATP binding site [chemical binding]; other site 110662006020 Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176 110662006021 threonine synthase; Reviewed; Region: PRK06721 110662006022 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 110662006023 homodimer interface [polypeptide binding]; other site 110662006024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 110662006025 catalytic residue [active]