-- dump date   	20120504_163702
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1080230000001	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1080230000002	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1080230000003	substrate binding pocket [chemical binding]; other site
1080230000004	chain length determination region; other site
1080230000005	substrate-Mg2+ binding site; other site
1080230000006	catalytic residues [active]
1080230000007	aspartate-rich region 1; other site
1080230000008	active site lid residues [active]
1080230000009	aspartate-rich region 2; other site
1080230000010	pseudouridine synthase; Region: TIGR00093
1080230000011	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1080230000012	active site
1080230000013	GUN4-like; Region: GUN4; pfam05419
1080230000014	Aerobic Cyclase System Fe-containing subunit (ACSF), ferritin-like diiron-binding domain; Region: ACSF; cd01047
1080230000015	diiron binding motif [ion binding]; other site
1080230000016	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1080230000017	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1080230000018	NADP binding site [chemical binding]; other site
1080230000019	active site
1080230000020	putative substrate binding site [chemical binding]; other site
1080230000021	GDP-mannose 4,6-dehydratase; Region: PLN02653
1080230000022	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1080230000023	NADP-binding site; other site
1080230000024	homotetramer interface [polypeptide binding]; other site
1080230000025	substrate binding site [chemical binding]; other site
1080230000026	homodimer interface [polypeptide binding]; other site
1080230000027	active site
1080230000028	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
1080230000029	protein I interface; other site
1080230000030	D2 interface; other site
1080230000031	protein T interface; other site
1080230000032	chlorophyll binding site; other site
1080230000033	beta carotene binding site; other site
1080230000034	pheophytin binding site; other site
1080230000035	manganese-stabilizing polypeptide interface; other site
1080230000036	CP43 interface; other site
1080230000037	protein L interface; other site
1080230000038	oxygen evolving complex binding site; other site
1080230000039	bromide binding site; other site
1080230000040	quinone binding site; other site
1080230000041	Fe binding site [ion binding]; other site
1080230000042	core light harvesting interface; other site
1080230000043	cytochrome b559 alpha subunit interface; other site
1080230000044	cytochrome c-550 interface; other site
1080230000045	protein J interface; other site
1080230000046	arginine decarboxylase; Provisional; Region: PRK05354
1080230000047	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1080230000048	active site
1080230000049	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1080230000050	catalytic residues [active]
1080230000051	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1080230000052	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1080230000053	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1080230000054	nucleotide binding pocket [chemical binding]; other site
1080230000055	K-X-D-G motif; other site
1080230000056	catalytic site [active]
1080230000057	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1080230000058	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1080230000059	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1080230000060	Dimer interface [polypeptide binding]; other site
1080230000061	BRCT sequence motif; other site
1080230000062	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000063	putative active site [active]
1080230000064	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1080230000065	ABC-ATPase subunit  interface; other site
1080230000066	dimer interface [polypeptide binding]; other site
1080230000067	putative PBP binding regions; other site
1080230000068	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1080230000069	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1080230000070	ABC-ATPase subunit  interface; other site
1080230000071	dimer interface [polypeptide binding]; other site
1080230000072	putative PBP binding regions; other site
1080230000073	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1080230000074	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1080230000075	Walker A/P-loop; other site
1080230000076	ATP binding site [chemical binding]; other site
1080230000077	Q-loop/lid; other site
1080230000078	ABC transporter signature motif; other site
1080230000079	Walker B; other site
1080230000080	D-loop; other site
1080230000081	H-loop/switch region; other site
1080230000082	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1080230000083	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1080230000084	siderophore binding site; other site
1080230000085	AMIN domain; Region: AMIN; pfam11741
1080230000086	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1080230000087	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1080230000088	N-terminal plug; other site
1080230000089	ligand-binding site [chemical binding]; other site
1080230000090	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1080230000091	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1080230000092	H+ Antiporter protein; Region: 2A0121; TIGR00900
1080230000093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230000094	putative substrate translocation pore; other site
1080230000095	TRX-like [2Fe-2S] Ferredoxin (Fd) family, Sucrase subfamily; composed of proteins with similarity to a novel plant enzyme, isolated from potato, which contains a Fd-like domain and exhibits sucrolytic activity. The putative active site of the Fd-like...; Region: TRX_Fd_Sucrase; cd03062
1080230000096	putative dimer interface [polypeptide binding]; other site
1080230000097	putative [2Fe-2S] cluster binding site [ion binding]; other site
1080230000098	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1080230000099	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1080230000100	siderophore binding site; other site
1080230000101	AMIN domain; Region: AMIN; pfam11741
1080230000102	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1080230000103	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1080230000104	N-terminal plug; other site
1080230000105	ligand-binding site [chemical binding]; other site
1080230000106	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1080230000107	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1080230000108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230000109	S-adenosylmethionine binding site [chemical binding]; other site
1080230000110	AMIN domain; Region: AMIN; pfam11741
1080230000111	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1080230000112	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1080230000113	N-terminal plug; other site
1080230000114	ligand-binding site [chemical binding]; other site
1080230000115	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1080230000116	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1080230000117	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1080230000118	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1080230000119	MORN repeat; Region: MORN; cl14787
1080230000120	MORN repeat; Region: MORN; cl14787
1080230000121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1080230000122	MORN repeat; Region: MORN; cl14787
1080230000123	phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185
1080230000124	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1080230000125	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230000126	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230000127	Walker A/P-loop; other site
1080230000128	ATP binding site [chemical binding]; other site
1080230000129	Q-loop/lid; other site
1080230000130	ABC transporter signature motif; other site
1080230000131	Walker B; other site
1080230000132	D-loop; other site
1080230000133	H-loop/switch region; other site
1080230000134	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1080230000135	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1080230000136	AMIN domain; Region: AMIN; pfam11741
1080230000137	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
1080230000138	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1080230000139	N-terminal plug; other site
1080230000140	ligand-binding site [chemical binding]; other site
1080230000141	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1080230000142	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1080230000143	siderophore binding site; other site
1080230000144	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1080230000145	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1080230000146	siderophore binding site; other site
1080230000147	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1080230000148	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1080230000149	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230000150	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230000151	Walker A/P-loop; other site
1080230000152	ATP binding site [chemical binding]; other site
1080230000153	Q-loop/lid; other site
1080230000154	ABC transporter signature motif; other site
1080230000155	Walker B; other site
1080230000156	D-loop; other site
1080230000157	H-loop/switch region; other site
1080230000158	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
1080230000159	Protein of unknown function (DUF433); Region: DUF433; cl01030
1080230000160	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
1080230000161	Psb28 protein; Region: Psb28; cl04326
1080230000162	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1080230000163	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230000164	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230000165	Helix-turn-helix domains; Region: HTH; cl00088
1080230000166	Integrase core domain; Region: rve; cl01316
1080230000167	Hydrogenase formation hypA family; Region: HypD; cl12072
1080230000168	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
1080230000169	dTDP-4-dehydrorhamnose reductase; Region: rmlD; TIGR01214
1080230000170	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1080230000171	NADP binding site [chemical binding]; other site
1080230000172	active site
1080230000173	putative substrate binding site [chemical binding]; other site
1080230000174	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
1080230000175	glycogen synthase; Provisional; Region: glgA; PRK00654
1080230000176	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1080230000177	ADP-binding pocket [chemical binding]; other site
1080230000178	homodimer interface [polypeptide binding]; other site
1080230000179	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1080230000180	Helix-turn-helix domains; Region: HTH; cl00088
1080230000181	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230000182	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1080230000183	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230000184	Walker A/P-loop; other site
1080230000185	ATP binding site [chemical binding]; other site
1080230000186	Q-loop/lid; other site
1080230000187	ABC transporter signature motif; other site
1080230000188	Walker B; other site
1080230000189	D-loop; other site
1080230000190	H-loop/switch region; other site
1080230000191	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1080230000192	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230000193	S-adenosylmethionine binding site [chemical binding]; other site
1080230000194	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986
1080230000195	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1080230000196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230000197	S-adenosylmethionine binding site [chemical binding]; other site
1080230000198	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1080230000199	active site
1080230000200	metal binding site [ion binding]; metal-binding site
1080230000201	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1080230000202	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
1080230000203	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1080230000204	active site
1080230000205	catalytic triad [active]
1080230000206	oxyanion hole [active]
1080230000207	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1080230000208	Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133
1080230000209	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
1080230000210	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
1080230000211	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1080230000212	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1080230000213	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
1080230000214	adenylate kinase; Reviewed; Region: adk; PRK00279
1080230000215	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1080230000216	AMP-binding site [chemical binding]; other site
1080230000217	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1080230000218	dihydrodipicolinate reductase; Region: dapB; TIGR00036
1080230000219	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000220	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1080230000221	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1080230000222	catalytic residues [active]
1080230000223	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1080230000224	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1080230000225	dimerization interface [polypeptide binding]; other site
1080230000226	ATP binding site [chemical binding]; other site
1080230000227	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1080230000228	dimerization interface [polypeptide binding]; other site
1080230000229	ATP binding site [chemical binding]; other site
1080230000230	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1080230000231	dimer interface [polypeptide binding]; other site
1080230000232	ADP-ribose binding site [chemical binding]; other site
1080230000233	active site
1080230000234	nudix motif; other site
1080230000235	metal binding site [ion binding]; metal-binding site
1080230000236	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1080230000237	carboxyltransferase (CT) interaction site; other site
1080230000238	biotinylation site [posttranslational modification]; other site
1080230000239	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
1080230000240	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1080230000241	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230000242	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1080230000243	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1080230000244	catalytic site [active]
1080230000245	G-X2-G-X-G-K; other site
1080230000246	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1080230000247	catalytic core [active]
1080230000248	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1080230000249	catalytic core [active]
1080230000250	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1080230000251	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1080230000252	active site
1080230000253	TDP-binding site; other site
1080230000254	acceptor substrate-binding pocket; other site
1080230000255	homodimer interface [polypeptide binding]; other site
1080230000256	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
1080230000257	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1080230000258	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1080230000259	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
1080230000260	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1080230000261	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1080230000262	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1080230000263	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1080230000264	homodimer interface [polypeptide binding]; other site
1080230000265	oligonucleotide binding site [chemical binding]; other site
1080230000266	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1080230000267	RNA/DNA hybrid binding site [nucleotide binding]; other site
1080230000268	active site
1080230000269	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1080230000270	active site
1080230000271	8-oxo-dGMP binding site [chemical binding]; other site
1080230000272	nudix motif; other site
1080230000273	metal binding site [ion binding]; metal-binding site
1080230000274	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1080230000275	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1080230000276	RNase E interface [polypeptide binding]; other site
1080230000277	trimer interface [polypeptide binding]; other site
1080230000278	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1080230000279	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1080230000280	RNase E interface [polypeptide binding]; other site
1080230000281	trimer interface [polypeptide binding]; other site
1080230000282	active site
1080230000283	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1080230000284	putative nucleic acid binding region [nucleotide binding]; other site
1080230000285	G-X-X-G motif; other site
1080230000286	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1080230000287	RNA binding site [nucleotide binding]; other site
1080230000288	domain interface; other site
1080230000289	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1080230000290	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1080230000291	Catalytic site [active]
1080230000292	ACT_MalLac-Enz CD includes the N-terminal ACT domain of putative NAD-dependent malic enzyme 1, Bacillus subtilis YqkI and related domains; Region: ACT_MalLac-Enz; cd04887
1080230000293	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1080230000294	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1080230000295	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1080230000296	putative NAD(P) binding site [chemical binding]; other site
1080230000297	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1080230000298	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1080230000299	dimer interface [polypeptide binding]; other site
1080230000300	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230000301	catalytic residue [active]
1080230000302	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK02534
1080230000303	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1080230000304	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
1080230000305	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230000306	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
1080230000307	RNA methyltransferase, RsmE family; Region: TIGR00046
1080230000308	Viral polyprotein N-terminal; Region: Calici_PP_N; pfam08405
1080230000309	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1080230000310	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
1080230000311	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1080230000312	O-Antigen ligase; Region: Wzy_C; cl04850
1080230000313	Protein of unknown function (DUF3181); Region: DUF3181; pfam11378
1080230000314	Protein of unknown function (DUF3119); Region: DUF3119; pfam11317
1080230000315	Protein of unknown function (DUF3086); Region: DUF3086; pfam11285
1080230000316	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1080230000317	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
1080230000318	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1080230000319	catalytic residue [active]
1080230000320	Phosphate-starvation-inducible E; Region: PsiE; cl01264
1080230000321	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1080230000322	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1080230000323	hypothetical protein; Region: PHA02414
1080230000324	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
1080230000325	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1080230000326	active site
1080230000327	DNA binding site [nucleotide binding]
1080230000328	Int/Topo IB signature motif; other site
1080230000329	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
1080230000330	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1080230000331	Integrase core domain; Region: rve; cl01316
1080230000332	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230000333	Helix-turn-helix domains; Region: HTH; cl00088
1080230000334	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1080230000335	dimerization interface [polypeptide binding]; other site
1080230000336	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1080230000337	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230000338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230000339	dimer interface [polypeptide binding]; other site
1080230000340	phosphorylation site [posttranslational modification]
1080230000341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230000342	ATP binding site [chemical binding]; other site
1080230000343	Mg2+ binding site [ion binding]; other site
1080230000344	G-X-G motif; other site
1080230000345	PsaD; Region: PsaD; cl03639
1080230000346	anthranilate synthase component I; Provisional; Region: PRK13565
1080230000347	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1080230000348	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1080230000349	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1080230000350	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1080230000351	substrate binding pocket [chemical binding]; other site
1080230000352	chain length determination region; other site
1080230000353	substrate-Mg2+ binding site; other site
1080230000354	catalytic residues [active]
1080230000355	aspartate-rich region 1; other site
1080230000356	active site lid residues [active]
1080230000357	aspartate-rich region 2; other site
1080230000358	CAAX protease self-immunity; Region: Abi; cl00558
1080230000359	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1080230000360	PhoU domain; Region: PhoU; pfam01895
1080230000361	PhoU domain; Region: PhoU; pfam01895
1080230000362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG0779
1080230000363	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
1080230000364	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
1080230000365	Sm1 motif; other site
1080230000366	D3 - B interaction site; other site
1080230000367	Hfq - Hfq interaction site; other site
1080230000368	RNA binding pocket [nucleotide binding]; other site
1080230000369	Sm2 motif; other site
1080230000370	NusA N-terminal domain; Region: NusA_N; pfam08529
1080230000371	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1080230000372	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1080230000373	RNA binding site [nucleotide binding]; other site
1080230000374	homodimer interface [polypeptide binding]; other site
1080230000375	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
1080230000376	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1080230000377	G-X-X-G motif; other site
1080230000378	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189
1080230000379	putative RNA binding cleft [nucleotide binding]; other site
1080230000380	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1080230000381	translation initiation factor IF-2; Region: IF-2; TIGR00487
1080230000382	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1080230000383	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1080230000384	G1 box; other site
1080230000385	putative GEF interaction site [polypeptide binding]; other site
1080230000386	GTP/Mg2+ binding site [chemical binding]; other site
1080230000387	Switch I region; other site
1080230000388	G2 box; other site
1080230000389	G3 box; other site
1080230000390	Switch II region; other site
1080230000391	G4 box; other site
1080230000392	G5 box; other site
1080230000393	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1080230000394	Translation-initiation factor 2; Region: IF-2; pfam11987
1080230000395	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1080230000396	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1080230000397	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
1080230000398	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
1080230000399	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1080230000400	active site
1080230000401	catalytic site [active]
1080230000402	Integrase core domain; Region: rve; cl01316
1080230000403	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
1080230000404	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
1080230000405	Helix-turn-helix domains; Region: HTH; cl00088
1080230000406	Peptidase family M48; Region: Peptidase_M48; cl12018
1080230000407	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1080230000408	catalytic triad [active]
1080230000409	Domain of unknown function DUF77; Region: DUF77; cl00307
1080230000410	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230000411	Ligand Binding Site [chemical binding]; other site
1080230000412	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230000413	Ligand Binding Site [chemical binding]; other site
1080230000414	Photosystem II reaction centre M protein (PsbM); Region: PsbM; cl11459
1080230000415	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1080230000416	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
1080230000417	Arginase family; Region: Arginase; cl00306
1080230000418	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
1080230000419	active site
1080230000420	Ycf4; Region: Ycf4; cl03567
1080230000421	GH3 auxin-responsive promoter; Region: GH3; cl04006
1080230000422	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1080230000423	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230000424	substrate binding pocket [chemical binding]; other site
1080230000425	membrane-bound complex binding site; other site
1080230000426	hinge residues; other site
1080230000427	Domain of unknown function (DUF1818); Region: DUF1818; pfam08848
1080230000428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1934
1080230000429	OstA-like protein; Region: OstA; cl00844
1080230000430	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1080230000431	The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218
1080230000432	Walker A/P-loop; other site
1080230000433	ATP binding site [chemical binding]; other site
1080230000434	Q-loop/lid; other site
1080230000435	ABC transporter signature motif; other site
1080230000436	Walker B; other site
1080230000437	D-loop; other site
1080230000438	H-loop/switch region; other site
1080230000439	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
1080230000440	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
1080230000441	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
1080230000442	Flagella accessory protein C (FlaC); Region: FlaC_arch; cl10488
1080230000443	NAD(P)H-quinone oxidoreductase subunit 2; Provisional; Region: PRK02504
1080230000444	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230000445	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1080230000446	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1080230000447	active site
1080230000448	metal binding site [ion binding]; metal-binding site
1080230000449	PetN; Region: PetN; cl15376
1080230000450	RDD family; Region: RDD; cl00746
1080230000451	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1080230000452	catalytic triad [active]
1080230000453	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1080230000454	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1080230000455	glutaminase active site [active]
1080230000456	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1080230000457	dimer interface [polypeptide binding]; other site
1080230000458	active site
1080230000459	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1080230000460	dimer interface [polypeptide binding]; other site
1080230000461	active site
1080230000462	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1080230000463	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230000464	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1080230000465	Flavin Reductases; Region: FlaRed; cl00801
1080230000466	Phosphate-starvation-inducible E; Region: PsiE; cl01264
1080230000467	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1080230000468	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230000469	Flavin Reductases; Region: FlaRed; cl00801
1080230000470	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1080230000471	C-terminal peptidase (prc); Region: prc; TIGR00225
1080230000472	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1080230000473	protein binding site [polypeptide binding]; other site
1080230000474	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1080230000475	Catalytic dyad [active]
1080230000476	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1080230000477	Protein of unknown function DUF111; Region: DUF111; cl03398
1080230000478	ATP synthase; Region: ATP-synt; cl00365
1080230000479	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
1080230000480	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1080230000481	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
1080230000482	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1080230000483	beta subunit interaction interface [polypeptide binding]; other site
1080230000484	Walker A motif; other site
1080230000485	ATP binding site [chemical binding]; other site
1080230000486	Walker B motif; other site
1080230000487	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1080230000488	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
1080230000489	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1080230000490	F0F1 ATP synthase subunit B; Validated; Region: PRK07352
1080230000491	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
1080230000492	F0F1 ATP synthase subunit B'; Validated; Region: PRK07353
1080230000493	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
1080230000494	ATP synthase subunit C; Region: ATP-synt_C; cl00466
1080230000495	ATP synthase A chain; Region: ATP-synt_A; cl00413
1080230000496	Predicted GTPase [General function prediction only]; Region: ThdF; COG0486
1080230000497	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230000498	G1 box; other site
1080230000499	GTP/Mg2+ binding site [chemical binding]; other site
1080230000500	G2 box; other site
1080230000501	Switch I region; other site
1080230000502	G3 box; other site
1080230000503	Switch II region; other site
1080230000504	Domain of unknown function (DUF697); Region: DUF697; cl12064
1080230000505	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
1080230000506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230000507	dimer interface [polypeptide binding]; other site
1080230000508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230000509	ATP binding site [chemical binding]; other site
1080230000510	Mg2+ binding site [ion binding]; other site
1080230000511	G-X-G motif; other site
1080230000512	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1080230000513	MoxR-like ATPases [General function prediction only]; Region: COG0714
1080230000514	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230000515	Walker A motif; other site
1080230000516	ATP binding site [chemical binding]; other site
1080230000517	Walker B motif; other site
1080230000518	arginine finger; other site
1080230000519	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1080230000520	EamA-like transporter family; Region: EamA; cl01037
1080230000521	EamA-like transporter family; Region: EamA; cl01037
1080230000522	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
1080230000523	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1080230000524	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
1080230000525	Walker A/P-loop; other site
1080230000526	ATP binding site [chemical binding]; other site
1080230000527	Q-loop/lid; other site
1080230000528	ABC transporter signature motif; other site
1080230000529	Walker B; other site
1080230000530	D-loop; other site
1080230000531	H-loop/switch region; other site
1080230000532	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1080230000533	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230000534	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1080230000535	catalytic center binding site [active]
1080230000536	ATP binding site [chemical binding]; other site
1080230000537	Protein of unknown function (DUF429); Region: DUF429; cl12046
1080230000538	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl00980
1080230000539	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000540	putative active site [active]
1080230000541	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1080230000542	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1080230000543	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1080230000544	Domain of unknown function (DUF1817); Region: DUF1817; cl02292
1080230000545	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1080230000546	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
1080230000547	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
1080230000548	aromatic acid decarboxylase; Validated; Region: PRK05920
1080230000549	Flavoprotein; Region: Flavoprotein; cl08021
1080230000550	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230000551	Ligand Binding Site [chemical binding]; other site
1080230000552	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230000553	Predicted component of the type VI protein secretion system, contains a FHA domain [Intracellular trafficking, secretion, and vesicular    transport; Signal transduction mechanisms]; Region: COG3456
1080230000554	phosphopeptide binding site; other site
1080230000555	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230000556	PAS domain; Region: PAS_9; pfam13426
1080230000557	putative active site [active]
1080230000558	heme pocket [chemical binding]; other site
1080230000559	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230000560	metal binding site [ion binding]; metal-binding site
1080230000561	active site
1080230000562	I-site; other site
1080230000563	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230000564	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230000565	phosphopeptide binding site; other site
1080230000566	PAS domain S-box; Region: sensory_box; TIGR00229
1080230000567	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230000568	metal binding site [ion binding]; metal-binding site
1080230000569	active site
1080230000570	I-site; other site
1080230000571	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230000572	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230000573	phosphopeptide binding site; other site
1080230000574	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230000575	metal binding site [ion binding]; metal-binding site
1080230000576	active site
1080230000577	I-site; other site
1080230000578	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230000579	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1080230000580	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
1080230000581	G1 box; other site
1080230000582	putative GEF interaction site [polypeptide binding]; other site
1080230000583	GTP/Mg2+ binding site [chemical binding]; other site
1080230000584	Switch I region; other site
1080230000585	G2 box; other site
1080230000586	G3 box; other site
1080230000587	Switch II region; other site
1080230000588	G4 box; other site
1080230000589	G5 box; other site
1080230000590	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1080230000591	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1080230000592	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1080230000593	NMT1-like family; Region: NMT1_2; cl15260
1080230000594	RNA polymerase sigma factor; Provisional; Region: PRK12525
1080230000595	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230000596	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1080230000597	active site
1080230000598	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
1080230000599	putative protein serine/threonine phosphatase; Provisional; Region: PRK14559
1080230000600	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1080230000601	active site
1080230000602	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1080230000603	putative trimer interface [polypeptide binding]; other site
1080230000604	putative CoA binding site [chemical binding]; other site
1080230000605	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1080230000606	Gamma carbonic anhydrases (CA): Carbonic anhydrases are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism, involving the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide, followed...; Region: LbH_gamma_CA; cd00710
1080230000607	trimer interface [polypeptide binding]; other site
1080230000608	active site
1080230000609	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1080230000610	putative multimerization interface [polypeptide binding]; other site
1080230000611	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1080230000612	putative multimerization interface [polypeptide binding]; other site
1080230000613	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1080230000614	putative multimerization interface [polypeptide binding]; other site
1080230000615	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit and related proteins. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of...; Region: RuBisCO_small_like; cd00307
1080230000616	putative multimerization interface [polypeptide binding]; other site
1080230000617	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
1080230000618	Hexamer/Pentamer interface [polypeptide binding]; other site
1080230000619	central pore; other site
1080230000620	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1080230000621	Hexamer interface [polypeptide binding]; other site
1080230000622	Hexagonal pore residue; other site
1080230000623	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1080230000624	Hexamer interface [polypeptide binding]; other site
1080230000625	Hexagonal pore residue; other site
1080230000626	glutamate synthases, NADH/NADPH, small subunit; Region: GOGAT_sm_gam; TIGR01317
1080230000627	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1080230000628	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1080230000629	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1080230000630	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1080230000631	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1080230000632	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1080230000633	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1080230000634	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1080230000635	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
1080230000636	Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile.  CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902
1080230000637	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
1080230000638	RecB family nuclease, putative, TM0106 family; Region: TIGR03491
1080230000639	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1080230000640	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
1080230000641	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1080230000642	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230000643	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230000644	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1080230000645	CemA family; Region: CemA; cl03855
1080230000646	cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442
1080230000647	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230000648	Walker A motif; other site
1080230000649	ATP binding site [chemical binding]; other site
1080230000650	Walker B motif; other site
1080230000651	arginine finger; other site
1080230000652	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
1080230000653	metal ion-dependent adhesion site (MIDAS); other site
1080230000654	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1080230000655	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1080230000656	homodimer interface [polypeptide binding]; other site
1080230000657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230000658	catalytic residue [active]
1080230000659	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1080230000660	alanine dehydrogenase; Region: alaDH; TIGR00518
1080230000661	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
1080230000662	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000663	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003
1080230000664	active site
1080230000665	hydrophilic channel; other site
1080230000666	dimerization interface [polypeptide binding]; other site
1080230000667	catalytic residues [active]
1080230000668	active site lid [active]
1080230000669	Protein of unknown function (DUF2488); Region: Ycf54; pfam10674
1080230000670	Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279
1080230000671	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
1080230000672	methionine sulfoxide reductase B; Provisional; Region: PRK00222; cl15841
1080230000673	SelR domain; Region: SelR; pfam01641
1080230000674	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1080230000675	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1080230000676	protein binding site [polypeptide binding]; other site
1080230000677	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1080230000678	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230000679	active site
1080230000680	phosphorylation site [posttranslational modification]
1080230000681	intermolecular recognition site; other site
1080230000682	dimerization interface [polypeptide binding]; other site
1080230000683	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230000684	DNA binding residues [nucleotide binding]
1080230000685	dimerization interface [polypeptide binding]; other site
1080230000686	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1080230000687	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000688	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
1080230000689	Nucleoside recognition; Region: Gate; cl00486
1080230000690	Nucleoside recognition; Region: Gate; cl00486
1080230000691	4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711
1080230000692	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1080230000693	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1080230000694	active site
1080230000695	metal binding site [ion binding]; metal-binding site
1080230000696	thiamine monophosphate kinase; Provisional; Region: PRK05731
1080230000697	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1080230000698	ATP binding site [chemical binding]; other site
1080230000699	dimerization interface [polypeptide binding]; other site
1080230000700	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230000701	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230000702	active site
1080230000703	phosphorylation site [posttranslational modification]
1080230000704	intermolecular recognition site; other site
1080230000705	dimerization interface [polypeptide binding]; other site
1080230000706	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230000707	putative active site [active]
1080230000708	heme pocket [chemical binding]; other site
1080230000709	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230000710	metal binding site [ion binding]; metal-binding site
1080230000711	active site
1080230000712	I-site; other site
1080230000713	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
1080230000714	MASE1; Region: MASE1; pfam05231
1080230000715	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230000716	dimer interface [polypeptide binding]; other site
1080230000717	phosphorylation site [posttranslational modification]
1080230000718	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230000719	ATP binding site [chemical binding]; other site
1080230000720	Mg2+ binding site [ion binding]; other site
1080230000721	G-X-G motif; other site
1080230000722	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230000723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230000724	active site
1080230000725	phosphorylation site [posttranslational modification]
1080230000726	intermolecular recognition site; other site
1080230000727	dimerization interface [polypeptide binding]; other site
1080230000728	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1080230000729	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230000730	Coenzyme A binding pocket [chemical binding]; other site
1080230000731	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
1080230000732	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1080230000733	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1080230000734	Active Sites [active]
1080230000735	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1080230000736	Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969
1080230000737	shikimate kinase; Reviewed; Region: aroK; PRK00131
1080230000738	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1080230000739	ADP binding site [chemical binding]; other site
1080230000740	magnesium binding site [ion binding]; other site
1080230000741	putative shikimate binding site; other site
1080230000742	transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309
1080230000743	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
1080230000744	active site
1080230000745	dimer interface [polypeptide binding]; other site
1080230000746	catalytic residue [active]
1080230000747	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl08302
1080230000748	Protein of unknown function (DUF2862); Region: DUF2862; pfam11061
1080230000749	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1080230000750	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1080230000751	P loop; other site
1080230000752	Nucleotide binding site [chemical binding]; other site
1080230000753	DTAP/Switch II; other site
1080230000754	Switch I; other site
1080230000755	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
1080230000756	Peptide methionine sulfoxide reductase; Region: PMSR; cl00366
1080230000757	Protein of unknown function (DUF2288); Region: DUF2288; cl02399
1080230000758	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230000759	TPR repeat; Region: TPR_11; pfam13414
1080230000760	binding surface
1080230000761	TPR motif; other site
1080230000762	TPR repeat; Region: TPR_11; pfam13414
1080230000763	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230000764	binding surface
1080230000765	TPR motif; other site
1080230000766	TPR repeat; Region: TPR_11; pfam13414
1080230000767	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230000768	binding surface
1080230000769	TPR motif; other site
1080230000770	TPR repeat; Region: TPR_11; pfam13414
1080230000771	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1080230000772	HSP70 interaction site [polypeptide binding]; other site
1080230000773	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1080230000774	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1080230000775	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230000776	active site
1080230000777	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1080230000778	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
1080230000779	prephenate dehydratase; Provisional; Region: PRK11898
1080230000780	Prephenate dehydratase; Region: PDT; pfam00800
1080230000781	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1080230000782	putative L-Phe binding site [chemical binding]; other site
1080230000783	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
1080230000784	MASE1; Region: MASE1; pfam05231
1080230000785	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230000786	metal binding site [ion binding]; metal-binding site
1080230000787	active site
1080230000788	I-site; other site
1080230000789	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1080230000790	FO synthase subunit 2; Reviewed; Region: PRK07360
1080230000791	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1080230000792	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1080230000793	active site
1080230000794	metal binding site [ion binding]; metal-binding site
1080230000795	Protein of unknown function (DUF3611); Region: DUF3611; pfam12263
1080230000796	birA, biotin-[acetyl-CoA-carboxylase] ligase region; Region: birA_ligase; TIGR00121
1080230000797	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1080230000798	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1080230000799	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230000800	Ligand Binding Site [chemical binding]; other site
1080230000801	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1080230000802	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230000803	S-adenosylmethionine binding site [chemical binding]; other site
1080230000804	Protein of unknown function (DUF3680); Region: DUF3680; cl02189
1080230000805	isocitrate dehydrogenase; Validated; Region: PRK07362
1080230000806	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1080230000807	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000808	putative active site [active]
1080230000809	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1080230000810	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK12561
1080230000811	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230000812	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
1080230000813	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000814	YGGT family; Region: YGGT; cl00508
1080230000815	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1080230000816	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230000817	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
1080230000818	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1080230000819	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1080230000820	active site
1080230000821	ADP/pyrophosphate binding site [chemical binding]; other site
1080230000822	dimerization interface [polypeptide binding]; other site
1080230000823	allosteric effector site; other site
1080230000824	fructose-1,6-bisphosphate binding site; other site
1080230000825	Predicted membrane protein [Function unknown]; Region: COG1289
1080230000826	UbiA prenyltransferase family; Region: UbiA; cl00337
1080230000827	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
1080230000828	Fusaric acid resistance protein-like; Region: FUSC_2; cl15844
1080230000829	photosystem II complex extrinsic protein precursor U; Provisional; Region: psbU; PRK02515
1080230000830	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1080230000831	active site
1080230000832	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1080230000833	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000834	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1080230000835	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000836	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK07364
1080230000837	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000838	CrcB-like protein; Region: CRCB; cl09114
1080230000839	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1080230000840	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1080230000841	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
1080230000842	TIGR03440 family protein; Region: unchr_TIGR03440
1080230000843	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; cl15394
1080230000844	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1080230000845	FAD binding domain; Region: FAD_binding_4; pfam01565
1080230000846	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230000847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230000848	active site
1080230000849	phosphorylation site [posttranslational modification]
1080230000850	intermolecular recognition site; other site
1080230000851	dimerization interface [polypeptide binding]; other site
1080230000852	PAS domain S-box; Region: sensory_box; TIGR00229
1080230000853	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230000854	putative active site [active]
1080230000855	heme pocket [chemical binding]; other site
1080230000856	PAS domain S-box; Region: sensory_box; TIGR00229
1080230000857	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230000858	putative active site [active]
1080230000859	heme pocket [chemical binding]; other site
1080230000860	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230000861	metal binding site [ion binding]; metal-binding site
1080230000862	active site
1080230000863	I-site; other site
1080230000864	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230000865	Domain of unknown function (DUF697); Region: DUF697; cl12064
1080230000866	Cupin superfamily (DUF985); Region: Cupin_5; cl01418
1080230000867	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
1080230000868	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000869	putative active site [active]
1080230000870	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl00433
1080230000871	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1080230000872	heme binding pocket [chemical binding]; other site
1080230000873	heme ligand [chemical binding]; other site
1080230000874	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
1080230000875	sulfite reductase subunit beta; Provisional; Region: PRK13504
1080230000876	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1080230000877	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1080230000878	Iron permease FTR1 family; Region: FTR1; cl00475
1080230000879	DNA polymerase III, beta subunit; Region: dnan; TIGR00663
1080230000880	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1080230000881	putative DNA binding surface [nucleotide binding]; other site
1080230000882	dimer interface [polypeptide binding]; other site
1080230000883	beta-clamp/clamp loader binding surface; other site
1080230000884	beta-clamp/translesion DNA polymerase binding surface; other site
1080230000885	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
1080230000886	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1080230000887	substrate binding site [chemical binding]; other site
1080230000888	active site
1080230000889	catalytic residues [active]
1080230000890	heterodimer interface [polypeptide binding]; other site
1080230000891	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230000892	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230000893	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230000894	Protein of unknown function (DUF1622); Region: DUF1622; cl01991
1080230000895	succinyldiaminopimelate transaminase; Validated; Region: PRK07366
1080230000896	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1080230000897	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230000898	homodimer interface [polypeptide binding]; other site
1080230000899	catalytic residue [active]
1080230000900	Bacterial SH3 domain; Region: SH3_3; cl02551
1080230000901	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
1080230000902	Cobalamin biosynthesis protein CbiG [Coenzyme metabolism]; Region: CbiG; COG2073
1080230000903	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1080230000904	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1080230000905	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
1080230000906	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
1080230000907	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
1080230000908	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
1080230000909	3-deoxy-7-phosphoheptulonate synthase; Provisional; Region: PRK13396
1080230000910	NeuB family; Region: NeuB; cl00496
1080230000911	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
1080230000912	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1080230000913	16S/18S rRNA binding site [nucleotide binding]; other site
1080230000914	S13e-L30e interaction site [polypeptide binding]; other site
1080230000915	25S rRNA binding site [nucleotide binding]; other site
1080230000916	Predicted permease; Region: DUF318; pfam03773
1080230000917	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
1080230000918	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230000919	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1080230000920	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1080230000921	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1080230000922	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1080230000923	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1080230000924	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1080230000925	FMN binding site [chemical binding]; other site
1080230000926	active site
1080230000927	catalytic residues [active]
1080230000928	substrate binding site [chemical binding]; other site
1080230000929	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000930	putative active site [active]
1080230000931	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1080230000932	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1080230000933	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1080230000934	Ubiquinol-cytochrome C chaperone; Region: Ubiq_cyt_C_chap; cl12045
1080230000935	Uncharacterized metal-binding protein (DUF2227); Region: DUF2227; cl01017
1080230000936	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
1080230000937	Chain length determinant protein; Region: Wzz; cl15801
1080230000938	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
1080230000939	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1080230000940	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000941	putative active site [active]
1080230000942	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1080230000943	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230000944	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000945	putative active site [active]
1080230000946	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1080230000947	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
1080230000948	Walker A/P-loop; other site
1080230000949	ATP binding site [chemical binding]; other site
1080230000950	Q-loop/lid; other site
1080230000951	ABC transporter signature motif; other site
1080230000952	Walker B; other site
1080230000953	D-loop; other site
1080230000954	H-loop/switch region; other site
1080230000955	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1080230000956	putative carbohydrate binding site [chemical binding]; other site
1080230000957	G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524
1080230000958	substrate binding site; other site
1080230000959	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1080230000960	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
1080230000961	NAD binding site [chemical binding]; other site
1080230000962	homotetramer interface [polypeptide binding]; other site
1080230000963	homodimer interface [polypeptide binding]; other site
1080230000964	substrate binding site [chemical binding]; other site
1080230000965	active site
1080230000966	Cupin domain; Region: Cupin_2; cl09118
1080230000967	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
1080230000968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230000969	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
1080230000970	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230000971	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000972	putative active site [active]
1080230000973	cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510
1080230000974	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230000975	putative active site [active]
1080230000976	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
1080230000977	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1080230000978	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1080230000979	inhibitor-cofactor binding pocket; inhibition site
1080230000980	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230000981	catalytic residue [active]
1080230000982	carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767
1080230000983	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230000984	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1080230000985	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230000986	NAD(P) binding site [chemical binding]; other site
1080230000987	active site
1080230000988	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230000989	S-adenosylmethionine binding site [chemical binding]; other site
1080230000990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230000991	PemK-like protein; Region: PemK; cl00995
1080230000992	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1080230000993	active site
1080230000994	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230000995	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1080230000996	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230000997	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
1080230000998	metal-binding site
1080230000999	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1080230001000	UDP-glucose-4-epimerase; Region: galE; TIGR01179
1080230001001	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1080230001002	NAD binding site [chemical binding]; other site
1080230001003	homodimer interface [polypeptide binding]; other site
1080230001004	active site
1080230001005	substrate binding site [chemical binding]; other site
1080230001006	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230001007	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230001008	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1080230001009	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1080230001010	active site
1080230001011	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
1080230001012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230001013	S-adenosylmethionine binding site [chemical binding]; other site
1080230001014	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1080230001015	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1080230001016	NADP-binding site; other site
1080230001017	homotetramer interface [polypeptide binding]; other site
1080230001018	substrate binding site [chemical binding]; other site
1080230001019	homodimer interface [polypeptide binding]; other site
1080230001020	active site
1080230001021	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230001022	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230001023	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230001024	Helix-turn-helix domains; Region: HTH; cl00088
1080230001025	Integrase core domain; Region: rve; cl01316
1080230001026	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230001027	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
1080230001028	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230001029	This family is most closely related to the GT1 family of glycosyltransferases. Bme6 in Brucella melitensis has been shown to be involved in the biosynthesis of a polysaccharide; Region: GT1_Bme6_like; cd03821
1080230001030	putative ADP-binding pocket [chemical binding]; other site
1080230001031	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230001032	YcfA-like protein; Region: YcfA; cl00752
1080230001033	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230001034	Protein of unknown function (DUF2283); Region: DUF2283; cl02251
1080230001035	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230001036	putative active site [active]
1080230001037	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230001038	putative active site [active]
1080230001039	putative acyl transferase; Provisional; Region: PRK10502
1080230001040	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
1080230001041	putative trimer interface [polypeptide binding]; other site
1080230001042	putative active site [active]
1080230001043	putative substrate binding site [chemical binding]; other site
1080230001044	putative CoA binding site [chemical binding]; other site
1080230001045	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
1080230001046	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1080230001047	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1080230001048	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1080230001049	hypothetical protein; Provisional; Region: PRK13683
1080230001050	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544
1080230001051	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
1080230001052	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230001053	Integral membrane protein TerC family; Region: TerC; cl10468
1080230001054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1080230001055	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1080230001056	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1080230001057	Ligand binding site; other site
1080230001058	Putative Catalytic site; other site
1080230001059	DXD motif; other site
1080230001060	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1080230001061	GTP1/OBG; Region: GTP1_OBG; pfam01018
1080230001062	Obg GTPase; Region: Obg; cd01898
1080230001063	G1 box; other site
1080230001064	GTP/Mg2+ binding site [chemical binding]; other site
1080230001065	Switch I region; other site
1080230001066	G2 box; other site
1080230001067	G3 box; other site
1080230001068	Switch II region; other site
1080230001069	G4 box; other site
1080230001070	G5 box; other site
1080230001071	light-harvesting-like protein 3; Provisional; Region: PLN00014
1080230001072	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230001073	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1080230001074	dihydroorotase; Provisional; Region: PRK07369
1080230001075	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1080230001076	active site
1080230001077	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1080230001078	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001079	active site
1080230001080	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230001081	phosphorylation site [posttranslational modification]
1080230001082	intermolecular recognition site; other site
1080230001083	dimerization interface [polypeptide binding]; other site
1080230001084	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230001085	dimer interface [polypeptide binding]; other site
1080230001086	phosphorylation site [posttranslational modification]
1080230001087	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230001088	ATP binding site [chemical binding]; other site
1080230001089	Mg2+ binding site [ion binding]; other site
1080230001090	G-X-G motif; other site
1080230001091	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230001092	Ligand Binding Site [chemical binding]; other site
1080230001093	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230001094	Ligand Binding Site [chemical binding]; other site
1080230001095	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204
1080230001096	SdiA-regulated; Region: SdiA-regulated; cd09971
1080230001097	putative active site [active]
1080230001098	Lamin Tail Domain; Region: LTD; pfam00932
1080230001099	Calx-beta domain; Region: Calx-beta; cl02522
1080230001100	Lamin Tail Domain; Region: LTD; pfam00932
1080230001101	Predicted extracellular nuclease [General function prediction only]; Region: COG2374
1080230001102	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1080230001103	generic binding surface II; other site
1080230001104	generic binding surface I; other site
1080230001105	Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283
1080230001106	putative active site [active]
1080230001107	putative catalytic site [active]
1080230001108	putative Mg binding site IVb [ion binding]; other site
1080230001109	putative phosphate binding site [ion binding]; other site
1080230001110	putative DNA binding site [nucleotide binding]; other site
1080230001111	putative Mg binding site IVa [ion binding]; other site
1080230001112	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230001113	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230001114	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1080230001115	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1080230001116	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
1080230001117	putative active site [active]
1080230001118	putative metal binding site [ion binding]; other site
1080230001119	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1080230001120	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230001121	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230001122	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
1080230001123	Gluconate kinase [Carbohydrate transport and metabolism]; Region: GntK; COG3265
1080230001124	ligand-binding site [chemical binding]; other site
1080230001125	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1080230001126	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1080230001127	16S rRNA methyltransferase B; Provisional; Region: PRK14901
1080230001128	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
1080230001129	putative RNA binding site [nucleotide binding]; other site
1080230001130	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230001131	tellurium resistance terB-like protein; Region: terB_like; cd07177
1080230001132	metal binding site [ion binding]; metal-binding site
1080230001133	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
1080230001134	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1080230001135	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1080230001136	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1080230001137	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1080230001138	NAD binding site [chemical binding]; other site
1080230001139	dimerization interface [polypeptide binding]; other site
1080230001140	product binding site; other site
1080230001141	substrate binding site [chemical binding]; other site
1080230001142	zinc binding site [ion binding]; other site
1080230001143	catalytic residues [active]
1080230001144	Integrase core domain; Region: rve; cl01316
1080230001145	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230001146	Helix-turn-helix domains; Region: HTH; cl00088
1080230001147	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230001148	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001149	active site
1080230001150	phosphorylation site [posttranslational modification]
1080230001151	intermolecular recognition site; other site
1080230001152	dimerization interface [polypeptide binding]; other site
1080230001153	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230001154	DNA binding site [nucleotide binding]
1080230001155	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1080230001156	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1080230001157	Mg++ binding site [ion binding]; other site
1080230001158	putative catalytic motif [active]
1080230001159	substrate binding site [chemical binding]; other site
1080230001160	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230001161	Predicted transmembrane sensor domain [Signal transduction mechanisms]; Region: COG4252
1080230001162	CHASE2 domain; Region: CHASE2; cl01732
1080230001163	CrcB-like protein; Region: CRCB; cl09114
1080230001164	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1080230001165	cyclase homology domain; Region: CHD; cd07302
1080230001166	nucleotidyl binding site; other site
1080230001167	metal binding site [ion binding]; metal-binding site
1080230001168	dimer interface [polypeptide binding]; other site
1080230001169	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1080230001170	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1080230001171	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230001172	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800
1080230001173	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230001174	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1080230001175	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001176	active site
1080230001177	phosphorylation site [posttranslational modification]
1080230001178	intermolecular recognition site; other site
1080230001179	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230001180	GAF domain; Region: GAF; cl15785
1080230001181	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230001182	metal binding site [ion binding]; metal-binding site
1080230001183	active site
1080230001184	I-site; other site
1080230001185	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1080230001186	transmembrane helices; other site
1080230001187	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
1080230001188	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
1080230001189	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1080230001190	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1080230001191	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
1080230001192	Domain of unknown function DUF39; Region: DUF39; cl14897
1080230001193	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1080230001194	DHH family; Region: DHH; pfam01368
1080230001195	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1080230001196	CHAT domain; Region: CHAT; pfam12770
1080230001197	ncharacterized protein conserved in bacteria [Function unknown]; Region: SpoIIIAA; COG3854
1080230001198	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230001199	Walker A motif; other site
1080230001200	ATP binding site [chemical binding]; other site
1080230001201	Walker B motif; other site
1080230001202	R3H domain of a group of proteins with unknown function, who also contain a AAA-ATPase (AAA) domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is...; Region: R3H_AAA; cd02645
1080230001203	RxxxH motif; other site
1080230001204	thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615
1080230001205	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1080230001206	thiamine phosphate binding site [chemical binding]; other site
1080230001207	active site
1080230001208	pyrophosphate binding site [ion binding]; other site
1080230001209	BtpA family; Region: BtpA; cl00440
1080230001210	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
1080230001211	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1080230001212	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1080230001213	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1080230001214	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1080230001215	active site
1080230001216	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230001217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001218	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001219	active site
1080230001220	phosphorylation site [posttranslational modification]
1080230001221	intermolecular recognition site; other site
1080230001222	dimerization interface [polypeptide binding]; other site
1080230001223	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1080230001224	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1080230001225	Exonuclease V gamma subunit [DNA replication, recombination, and repair]; Region: RecC; COG1330
1080230001226	CemA family; Region: CemA; cl03855
1080230001227	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
1080230001228	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1080230001229	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1080230001230	P-loop; other site
1080230001231	Magnesium ion binding site [ion binding]; other site
1080230001232	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1080230001233	Magnesium ion binding site [ion binding]; other site
1080230001234	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
1080230001235	putative dimer interface [polypeptide binding]; other site
1080230001236	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1080230001237	Helix-turn-helix domains; Region: HTH; cl00088
1080230001238	lipoyl synthase; Provisional; Region: PRK05481
1080230001239	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230001240	FeS/SAM binding site; other site
1080230001241	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1080230001242	putative trimer interface [polypeptide binding]; other site
1080230001243	putative CoA binding site [chemical binding]; other site
1080230001244	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1080230001245	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1080230001246	Protein of unknown function (DUF565); Region: DUF565; pfam04483
1080230001247	Phospholipid methyltransferase; Region: PEMT; cl00763
1080230001248	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
1080230001249	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1080230001250	UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512
1080230001251	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
1080230001252	FtsH Extracellular; Region: FtsH_ext; pfam06480
1080230001253	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1080230001254	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230001255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230001256	Walker A motif; other site
1080230001257	ATP binding site [chemical binding]; other site
1080230001258	Walker B motif; other site
1080230001259	arginine finger; other site
1080230001260	Peptidase family M41; Region: Peptidase_M41; pfam01434
1080230001261	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230001262	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1080230001263	oligomeric interface; other site
1080230001264	putative active site [active]
1080230001265	homodimer interface [polypeptide binding]; other site
1080230001266	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1080230001267	Protein of unknown function DUF86; Region: DUF86; cl01031
1080230001268	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1080230001269	active site
1080230001270	NTP binding site [chemical binding]; other site
1080230001271	metal binding triad [ion binding]; metal-binding site
1080230001272	antibiotic binding site [chemical binding]; other site
1080230001273	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1080230001274	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
1080230001275	putative active site [active]
1080230001276	putative NTP binding site [chemical binding]; other site
1080230001277	putative nucleic acid binding site [nucleotide binding]; other site
1080230001278	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1080230001279	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1080230001280	active site
1080230001281	dimer interface [polypeptide binding]; other site
1080230001282	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1080230001283	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1080230001284	active site
1080230001285	FMN binding site [chemical binding]; other site
1080230001286	substrate binding site [chemical binding]; other site
1080230001287	3Fe-4S cluster binding site [ion binding]; other site
1080230001288	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1080230001289	domain interface; other site
1080230001290	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1080230001291	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1080230001292	cobyrinic acid a,c-diamide synthase; Region: cobB; TIGR00379
1080230001293	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230001294	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1080230001295	catalytic triad [active]
1080230001296	NaMN:DMB phosphoribosyltransferase [Coenzyme metabolism]; Region: CobT; COG2038
1080230001297	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cl11435
1080230001298	putative dimer interface [polypeptide binding]; other site
1080230001299	active site pocket [active]
1080230001300	putative cataytic base [active]
1080230001301	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1080230001302	AMP-binding enzyme; Region: AMP-binding; cl15778
1080230001303	Domain of unknown function (DUF4388); Region: DUF4388; pfam14332
1080230001304	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001306	active site
1080230001307	phosphorylation site [posttranslational modification]
1080230001308	intermolecular recognition site; other site
1080230001309	dimerization interface [polypeptide binding]; other site
1080230001310	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001311	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001312	active site
1080230001313	phosphorylation site [posttranslational modification]
1080230001314	intermolecular recognition site; other site
1080230001315	dimerization interface [polypeptide binding]; other site
1080230001316	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1080230001317	putative CheA interaction surface; other site
1080230001318	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230001319	binding surface
1080230001320	TPR motif; other site
1080230001321	Domain of unknown function (DUF4331); Region: DUF4331; pfam14224
1080230001322	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1080230001323	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1080230001324	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1080230001325	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1080230001326	dimer interface [polypeptide binding]; other site
1080230001327	putative CheW interface [polypeptide binding]; other site
1080230001328	Permease; Region: Permease; cl00510
1080230001329	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1080230001330	GAF domain; Region: GAF; cl15785
1080230001331	GAF domain; Region: GAF_2; pfam13185
1080230001332	two component system sensor kinase SsrA; Provisional; Region: PRK15347
1080230001333	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230001334	metal binding site [ion binding]; metal-binding site
1080230001335	active site
1080230001336	I-site; other site
1080230001337	exonuclease SbcC; Region: sbcc; TIGR00618
1080230001338	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230001339	Walker A/P-loop; other site
1080230001340	ATP binding site [chemical binding]; other site
1080230001341	Q-loop/lid; other site
1080230001342	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
1080230001343	ABC transporter signature motif; other site
1080230001344	Walker B; other site
1080230001345	D-loop; other site
1080230001346	H-loop/switch region; other site
1080230001347	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1080230001348	HSP70 interaction site [polypeptide binding]; other site
1080230001349	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230001350	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230001351	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230001352	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
1080230001353	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230001354	Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928
1080230001355	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
1080230001356	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1080230001357	NAD binding site [chemical binding]; other site
1080230001358	homotetramer interface [polypeptide binding]; other site
1080230001359	homodimer interface [polypeptide binding]; other site
1080230001360	substrate binding site [chemical binding]; other site
1080230001361	active site
1080230001362	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1080230001363	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1080230001364	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1080230001365	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1080230001366	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1080230001367	magnesium chelatase subunit H; Provisional; Region: PRK12493
1080230001368	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
1080230001369	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1080230001370	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1080230001371	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
1080230001372	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230001373	Walker A/P-loop; other site
1080230001374	ATP binding site [chemical binding]; other site
1080230001375	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1080230001376	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1080230001377	homodimer interface [polypeptide binding]; other site
1080230001378	MazG family protein; Region: mazG; TIGR00444
1080230001379	metal binding site [ion binding]; metal-binding site
1080230001380	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529
1080230001381	homodimer interface [polypeptide binding]; other site
1080230001382	active site
1080230001383	putative chemical substrate binding site [chemical binding]; other site
1080230001384	metal binding site [ion binding]; metal-binding site
1080230001385	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1080230001386	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230001387	active site
1080230001388	PAS fold; Region: PAS_3; pfam08447
1080230001389	PAS domain S-box; Region: sensory_box; TIGR00229
1080230001390	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230001391	putative active site [active]
1080230001392	heme pocket [chemical binding]; other site
1080230001393	PAS domain S-box; Region: sensory_box; TIGR00229
1080230001394	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230001395	putative active site [active]
1080230001396	heme pocket [chemical binding]; other site
1080230001397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230001398	dimer interface [polypeptide binding]; other site
1080230001399	phosphorylation site [posttranslational modification]
1080230001400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230001401	ATP binding site [chemical binding]; other site
1080230001402	Mg2+ binding site [ion binding]; other site
1080230001403	G-X-G motif; other site
1080230001404	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230001405	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230001406	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1080230001407	mce related protein; Region: MCE; pfam02470
1080230001408	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
1080230001409	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1080230001410	ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261
1080230001411	Walker A/P-loop; other site
1080230001412	ATP binding site [chemical binding]; other site
1080230001413	Q-loop/lid; other site
1080230001414	ABC transporter signature motif; other site
1080230001415	Walker B; other site
1080230001416	D-loop; other site
1080230001417	H-loop/switch region; other site
1080230001418	Large exoproteins involved in heme utilization or adhesion [Intracellular trafficking and secretion]; Region: FhaB; COG3210
1080230001419	haemagglutination activity domain; Region: Haemagg_act; cl05436
1080230001420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1080230001421	CHAT domain; Region: CHAT; pfam12770
1080230001422	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Provisional; Region: PRK14619
1080230001423	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230001424	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1080230001425	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1080230001426	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230001427	glutamine synthetase, type I; Region: GlnA; TIGR00653
1080230001428	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1080230001429	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1080230001430	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
1080230001431	CHASE domain; Region: CHASE; cl01369
1080230001432	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1080230001433	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230001434	putative active site [active]
1080230001435	heme pocket [chemical binding]; other site
1080230001436	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230001437	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1080230001438	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230001439	GAF domain; Region: GAF; cl15785
1080230001440	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230001441	dimer interface [polypeptide binding]; other site
1080230001442	phosphorylation site [posttranslational modification]
1080230001443	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230001444	ATP binding site [chemical binding]; other site
1080230001445	Mg2+ binding site [ion binding]; other site
1080230001446	G-X-G motif; other site
1080230001447	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001448	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001449	active site
1080230001450	phosphorylation site [posttranslational modification]
1080230001451	intermolecular recognition site; other site
1080230001452	dimerization interface [polypeptide binding]; other site
1080230001453	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001454	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001455	active site
1080230001456	phosphorylation site [posttranslational modification]
1080230001457	intermolecular recognition site; other site
1080230001458	dimerization interface [polypeptide binding]; other site
1080230001459	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1080230001460	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001461	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001462	active site
1080230001463	phosphorylation site [posttranslational modification]
1080230001464	intermolecular recognition site; other site
1080230001465	dimerization interface [polypeptide binding]; other site
1080230001466	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230001467	metal binding site [ion binding]; metal-binding site
1080230001468	active site
1080230001469	I-site; other site
1080230001470	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
1080230001471	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
1080230001472	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1080230001473	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230001474	motif II; other site
1080230001475	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
1080230001476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230001477	S-adenosylmethionine binding site [chemical binding]; other site
1080230001478	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
1080230001479	Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310
1080230001480	Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974
1080230001481	putative metal binding site [ion binding]; other site
1080230001482	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
1080230001483	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1080230001484	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230001485	catalytic residue [active]
1080230001486	Protein of unknown function (DUF433); Region: DUF433; cl01030
1080230001487	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
1080230001488	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1080230001489	Pseudomonas sp. MCI3434 R-amidase and related proteins (putative class 13 nitrilases); Region: R-amidase_like; cd07576
1080230001490	putative active site [active]
1080230001491	catalytic triad [active]
1080230001492	putative dimer interface [polypeptide binding]; other site
1080230001493	UreD urease accessory protein; Region: UreD; cl00530
1080230001494	Oxygen evolving enhancer protein 3 (PsbQ); Region: PsbQ; cl05363
1080230001495	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1080230001496	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_1; cd03400
1080230001497	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1080230001498	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1080230001499	trimer interface [polypeptide binding]; other site
1080230001500	putative metal binding site [ion binding]; other site
1080230001501	putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976
1080230001502	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230001503	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
1080230001504	Thymidylate synthase complementing protein; Region: Thy1; cl03630
1080230001505	Photosystem II 4 kDa reaction centre component; Region: PsbK; cl03641
1080230001506	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230001507	putative acyl-acceptor binding pocket; other site
1080230001508	BolA-like protein; Region: BolA; cl00386
1080230001509	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1080230001510	putative GSH binding site [chemical binding]; other site
1080230001511	catalytic residues [active]
1080230001512	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
1080230001513	Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815
1080230001514	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1080230001515	NAD binding site [chemical binding]; other site
1080230001516	dimerization interface [polypeptide binding]; other site
1080230001517	product binding site; other site
1080230001518	substrate binding site [chemical binding]; other site
1080230001519	zinc binding site [ion binding]; other site
1080230001520	catalytic residues [active]
1080230001521	mercuric reductase; Validated; Region: PRK06370
1080230001522	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1080230001523	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1080230001524	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1080230001525	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1080230001526	subunit interactions [polypeptide binding]; other site
1080230001527	active site
1080230001528	flap region; other site
1080230001529	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230001530	2TM domain; Region: 2TM; pfam13239
1080230001531	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230001532	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230001533	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230001534	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230001535	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230001536	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230001537	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230001538	binding surface
1080230001539	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1080230001540	TPR motif; other site
1080230001541	Protein of unknown function (DUF561); Region: DUF561; pfam04481
1080230001542	1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204
1080230001543	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1080230001544	TPP-binding site; other site
1080230001545	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1080230001546	PYR/PP interface [polypeptide binding]; other site
1080230001547	dimer interface [polypeptide binding]; other site
1080230001548	TPP binding site [chemical binding]; other site
1080230001549	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1080230001550	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
1080230001551	Rubredoxin; Region: Rubredoxin; pfam00301
1080230001552	iron binding site [ion binding]; other site
1080230001553	Ycf48-like protein; Provisional; Region: PRK13684
1080230001554	cytochrome b559 subunit alpha; Provisional; Region: psbE; PRK02557
1080230001555	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834
1080230001556	Lumenal portion of Cytochrome b559, alpha (gene psbE) subunit; Region: Cytochrom_B559a; pfam00284
1080230001557	Cytochrome b559, alpha (gene psbE) and beta (gene psbF)subunits; Region: Cytochrom_B559; cl02834
1080230001558	PsbL protein; Region: PsbL; cl03581
1080230001559	PsbJ; Region: PsbJ; cl09469
1080230001560	gamma-glutamyl kinase; Provisional; Region: PRK05429
1080230001561	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1080230001562	nucleotide binding site [chemical binding]; other site
1080230001563	homotetrameric interface [polypeptide binding]; other site
1080230001564	putative phosphate binding site [ion binding]; other site
1080230001565	putative allosteric binding site; other site
1080230001566	PUA domain; Region: PUA; cl00607
1080230001567	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230001568	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230001569	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230001570	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230001571	putative active site [active]
1080230001572	Type IV pilus biogenesis; Region: Pilus_PilP; cl11837
1080230001573	DNA Topoisomerase IV; Region: TOP4c; smart00434
1080230001574	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
1080230001575	CAP-like domain; other site
1080230001576	active site
1080230001577	primary dimer interface [polypeptide binding]; other site
1080230001578	DNA double-strand break repair and V(D)J recombination protein XRCC4; Region: XRCC4; pfam06632
1080230001579	Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit [DNA replication, recombination, and repair]; Region: GyrA; COG0188
1080230001580	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001581	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001582	active site
1080230001583	phosphorylation site [posttranslational modification]
1080230001584	intermolecular recognition site; other site
1080230001585	dimerization interface [polypeptide binding]; other site
1080230001586	Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; cl01267
1080230001587	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1080230001588	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230001589	putative active site [active]
1080230001590	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1080230001591	metal binding site 2 [ion binding]; metal-binding site
1080230001592	putative DNA binding helix; other site
1080230001593	metal binding site 1 [ion binding]; metal-binding site
1080230001594	dimer interface [polypeptide binding]; other site
1080230001595	structural Zn2+ binding site [ion binding]; other site
1080230001596	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
1080230001597	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1080230001598	putative metal binding residues [ion binding]; other site
1080230001599	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1080230001600	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
1080230001601	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1080230001602	ABC-ATPase subunit  interface; other site
1080230001603	dimer interface [polypeptide binding]; other site
1080230001604	putative PBP binding regions; other site
1080230001605	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230001606	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230001607	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001608	Ca2+ binding site [ion binding]; other site
1080230001609	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001610	Ca2+ binding site [ion binding]; other site
1080230001611	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001612	Ca2+ binding site [ion binding]; other site
1080230001613	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001614	Ca2+ binding site [ion binding]; other site
1080230001615	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001616	Ca2+ binding site [ion binding]; other site
1080230001617	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001618	Ca2+ binding site [ion binding]; other site
1080230001619	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001620	Ca2+ binding site [ion binding]; other site
1080230001621	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001622	Ca2+ binding site [ion binding]; other site
1080230001623	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001624	Ca2+ binding site [ion binding]; other site
1080230001625	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1080230001626	Ca2+ binding site [ion binding]; other site
1080230001627	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230001628	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230001629	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1080230001630	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230001631	TPR repeat; Region: TPR_11; pfam13414
1080230001632	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230001633	binding surface
1080230001634	TPR motif; other site
1080230001635	TPR repeat; Region: TPR_11; pfam13414
1080230001636	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230001637	binding surface
1080230001638	TPR motif; other site
1080230001639	TPR repeat; Region: TPR_11; pfam13414
1080230001640	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
1080230001641	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1080230001642	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230001643	TPR motif; other site
1080230001644	binding surface
1080230001645	CpeS-like protein; Region: CpeS; pfam09367
1080230001646	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1080230001647	alpha/beta hydrolase fold protein; Provisional; Region: PLN03084
1080230001648	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
1080230001649	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1080230001650	HSP70 interaction site [polypeptide binding]; other site
1080230001651	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1080230001652	substrate binding site [polypeptide binding]; other site
1080230001653	dimer interface [polypeptide binding]; other site
1080230001654	molecular chaperone DnaK; Provisional; Region: PRK13410
1080230001655	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1080230001656	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1080230001657	dimer interface [polypeptide binding]; other site
1080230001658	active site
1080230001659	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1080230001660	folate binding site [chemical binding]; other site
1080230001661	Integrase core domain; Region: rve; cl01316
1080230001662	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1080230001663	Competence protein; Region: Competence; cl00471
1080230001664	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1080230001665	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230001666	Coenzyme A binding pocket [chemical binding]; other site
1080230001667	S-layer homology domain; Region: SLH; pfam00395
1080230001668	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230001669	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001670	active site
1080230001671	phosphorylation site [posttranslational modification]
1080230001672	intermolecular recognition site; other site
1080230001673	dimerization interface [polypeptide binding]; other site
1080230001674	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230001675	DNA binding residues [nucleotide binding]
1080230001676	dimerization interface [polypeptide binding]; other site
1080230001677	AMIN domain; Region: AMIN; pfam11741
1080230001678	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1080230001679	active site
1080230001680	metal binding site [ion binding]; metal-binding site
1080230001681	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
1080230001682	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1080230001683	anti sigma factor interaction site; other site
1080230001684	regulatory phosphorylation site [posttranslational modification]; other site
1080230001685	Uncharacterized protein conserved in archaea (DUF2226); Region: DUF2226; cl00724
1080230001686	TolB amino-terminal domain; Region: TolB_N; cl00639
1080230001687	TM2 domain; Region: TM2; cl00984
1080230001688	Domain of unknown function (DUF1825); Region: DUF1825; pfam08855
1080230001689	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is 'interfacial activation', the process of becoming...; Region: Lipase; cl14883
1080230001690	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230001691	nucleophilic elbow; other site
1080230001692	catalytic triad; other site
1080230001693	hydrolase, alpha/beta fold family protein; Region: PLN02824
1080230001694	Protein of unknown function (DUF3353); Region: DUF3353; pfam11833
1080230001695	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1080230001696	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1080230001697	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230001698	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1080230001699	Cysteine-rich domain; Region: CCG; pfam02754
1080230001700	Cysteine-rich domain; Region: CCG; pfam02754
1080230001701	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1080230001702	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230001703	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
1080230001704	Helix-turn-helix domains; Region: HTH; cl00088
1080230001705	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1080230001706	putative dimerization interface [polypeptide binding]; other site
1080230001707	phenazine biosynthesis protein PhzF family; Region: PhzF_family; TIGR00654
1080230001708	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14333
1080230001709	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1080230001710	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230001711	FeS/SAM binding site; other site
1080230001712	TRAM domain; Region: TRAM; cl01282
1080230001713	UDP_sulfoquinovose_synthase (Arabidopsis thaliana SQD1 and related proteins), extended (e) SDRs; Region: SQD1_like_SDR_e; cd05255
1080230001714	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1080230001715	NAD binding site [chemical binding]; other site
1080230001716	substrate binding site [chemical binding]; other site
1080230001717	active site
1080230001718	Protein of unknown function (DUF2470); Region: DUF2470; pfam10615
1080230001719	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230001720	putative active site [active]
1080230001721	Protein of unknown function (DUF1449); Region: DUF1449; pfam07290
1080230001722	Ion channel; Region: Ion_trans_2; cl11596
1080230001723	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1080230001724	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230001725	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
1080230001726	acetylornithine aminotransferase; Provisional; Region: PRK02627
1080230001727	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1080230001728	inhibitor-cofactor binding pocket; inhibition site
1080230001729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230001730	catalytic residue [active]
1080230001731	Cupin domain; Region: Cupin_2; cl09118
1080230001732	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
1080230001733	Predicted esterase [General function prediction only]; Region: COG0627
1080230001734	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230001735	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
1080230001736	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
1080230001737	substrate binding site [chemical binding]; other site
1080230001738	catalytic Zn binding site [ion binding]; other site
1080230001739	NAD binding site [chemical binding]; other site
1080230001740	structural Zn binding site [ion binding]; other site
1080230001741	dimer interface [polypeptide binding]; other site
1080230001742	cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059
1080230001743	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
1080230001744	FG-GAP repeat; Region: FG-GAP; cl15299
1080230001745	FG-GAP repeat; Region: FG-GAP; cl15299
1080230001746	FG-GAP repeat; Region: FG-GAP; cl15299
1080230001747	Bulb-type mannose-specific lectin; Region: B_lectin; smart00108
1080230001748	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1080230001749	dimerization interface [polypeptide binding]; other site
1080230001750	mannose binding site [chemical binding]; other site
1080230001751	Family description; Region: VCBS; pfam13517
1080230001752	FG-GAP repeat; Region: FG-GAP; cl15299
1080230001753	FG-GAP repeat; Region: FG-GAP; cl15299
1080230001754	Calx-beta domain; Region: Calx-beta; cl02522
1080230001755	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1080230001756	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
1080230001757	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230001758	Walker A motif; other site
1080230001759	ATP binding site [chemical binding]; other site
1080230001760	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1080230001761	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1080230001762	active site
1080230001763	HIGH motif; other site
1080230001764	dimer interface [polypeptide binding]; other site
1080230001765	KMSKS motif; other site
1080230001766	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1080230001767	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1080230001768	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1080230001769	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1080230001770	dimer interface [polypeptide binding]; other site
1080230001771	ssDNA binding site [nucleotide binding]; other site
1080230001772	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1080230001773	GIY-YIG domain found in CAXIP1-like proteins, iron-sulfur cluster assembly proteins, and similar proteins; Region: GIY-YIG_AtGrxS16_like; cd10450
1080230001774	GIY-YIG motif/motif A; other site
1080230001775	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1080230001776	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230001777	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1080230001778	active site
1080230001779	metal binding site [ion binding]; metal-binding site
1080230001780	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001781	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001782	active site
1080230001783	phosphorylation site [posttranslational modification]
1080230001784	intermolecular recognition site; other site
1080230001785	dimerization interface [polypeptide binding]; other site
1080230001786	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230001787	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
1080230001788	RNA/DNA hybrid binding site [nucleotide binding]; other site
1080230001789	active site
1080230001790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230001791	S-adenosylmethionine binding site [chemical binding]; other site
1080230001792	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1080230001793	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1080230001794	Catalytic site [active]
1080230001795	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230001796	putative active site [active]
1080230001797	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
1080230001798	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1080230001799	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230001800	Acetokinase family; Region: Acetate_kinase; cl01029
1080230001801	acetate kinase; Region: ackA; TIGR00016
1080230001802	Dienelactone hydrolase family; Region: DLH; pfam01738
1080230001803	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230001804	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230001805	conserved hypothetical protein; Region: TIGR03492
1080230001806	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230001807	GAF domain; Region: GAF; cl15785
1080230001808	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230001809	PAS domain; Region: PAS_9; pfam13426
1080230001810	putative active site [active]
1080230001811	heme pocket [chemical binding]; other site
1080230001812	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1080230001813	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1080230001814	[2Fe-2S] cluster binding site [ion binding]; other site
1080230001815	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230001816	catalytic loop [active]
1080230001817	iron binding site [ion binding]; other site
1080230001818	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1080230001819	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1080230001820	putative binding surface; other site
1080230001821	active site
1080230001822	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1080230001823	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230001824	ATP binding site [chemical binding]; other site
1080230001825	Mg2+ binding site [ion binding]; other site
1080230001826	G-X-G motif; other site
1080230001827	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1080230001828	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001829	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001830	active site
1080230001831	phosphorylation site [posttranslational modification]
1080230001832	intermolecular recognition site; other site
1080230001833	dimerization interface [polypeptide binding]; other site
1080230001834	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1080230001835	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1080230001836	dimerization interface [polypeptide binding]; other site
1080230001837	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1080230001838	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1080230001839	dimer interface [polypeptide binding]; other site
1080230001840	putative CheW interface [polypeptide binding]; other site
1080230001841	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1080230001842	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001844	active site
1080230001845	phosphorylation site [posttranslational modification]
1080230001846	intermolecular recognition site; other site
1080230001847	dimerization interface [polypeptide binding]; other site
1080230001848	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230001849	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230001850	active site
1080230001851	phosphorylation site [posttranslational modification]
1080230001852	intermolecular recognition site; other site
1080230001853	dimerization interface [polypeptide binding]; other site
1080230001854	Exoribonuclease R [Transcription]; Region: VacB; COG0557
1080230001855	RNB domain; Region: RNB; pfam00773
1080230001856	Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969
1080230001857	putative catalytic residue [active]
1080230001858	cell division protein; Validated; Region: ftsH; CHL00176
1080230001859	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230001860	Walker A motif; other site
1080230001861	ATP binding site [chemical binding]; other site
1080230001862	Walker B motif; other site
1080230001863	arginine finger; other site
1080230001864	Peptidase family M41; Region: Peptidase_M41; pfam01434
1080230001865	FeoA domain; Region: FeoA; cl00838
1080230001866	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1080230001867	ferrous iron transporter FeoB; Region: feoB; TIGR00437
1080230001868	G1 box; other site
1080230001869	GTP/Mg2+ binding site [chemical binding]; other site
1080230001870	Switch I region; other site
1080230001871	G2 box; other site
1080230001872	G3 box; other site
1080230001873	Switch II region; other site
1080230001874	G4 box; other site
1080230001875	G5 box; other site
1080230001876	Nucleoside recognition; Region: Gate; cl00486
1080230001877	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1080230001878	Nucleoside recognition; Region: Gate; cl00486
1080230001879	ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554
1080230001880	light-harvesting-like protein 3; Provisional; Region: PLN00014
1080230001881	GAF domain; Region: GAF_2; pfam13185
1080230001882	GAF domain; Region: GAF; cl15785
1080230001883	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230001884	GAF domain; Region: GAF; cl15785
1080230001885	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230001886	GAF domain; Region: GAF; cl15785
1080230001887	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1080230001888	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230001889	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230001890	dimer interface [polypeptide binding]; other site
1080230001891	phosphorylation site [posttranslational modification]
1080230001892	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230001893	ATP binding site [chemical binding]; other site
1080230001894	Mg2+ binding site [ion binding]; other site
1080230001895	G-X-G motif; other site
1080230001896	Divergent PAP2 family; Region: DUF212; cl00855
1080230001897	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1080230001898	Helix-turn-helix domains; Region: HTH; cl00088
1080230001899	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
1080230001900	RNAse P Rpr2/Rpp21/SNM1 subunit domain; Region: Rpr2; cl00887
1080230001901	FO synthase subunit 1; Reviewed; Region: cofG; PRK06245
1080230001902	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230001903	FeS/SAM binding site; other site
1080230001904	Predicted esterase [General function prediction only]; Region: COG0400
1080230001905	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230001906	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
1080230001907	Stage II sporulation protein; Region: SpoIID; pfam08486
1080230001908	Protein of unknown function (DUF1350); Region: DUF1350; pfam07082
1080230001909	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1080230001910	dimer interface [polypeptide binding]; other site
1080230001911	[2Fe-2S] cluster binding site [ion binding]; other site
1080230001912	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1080230001913	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1080230001914	Dimer interface [polypeptide binding]; other site
1080230001915	BRCT sequence motif; other site
1080230001916	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1080230001917	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1080230001918	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230001919	ATP binding site [chemical binding]; other site
1080230001920	putative Mg++ binding site [ion binding]; other site
1080230001921	Family description; Region: UvrD_C_2; cl15862
1080230001922	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1080230001923	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1080230001924	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
1080230001925	SLBB domain; Region: SLBB; pfam10531
1080230001926	Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726
1080230001927	Domain of unknown function (DUF1995); Region: DUF1995; pfam09353
1080230001928	seryl-tRNA synthetase; Provisional; Region: PRK05431
1080230001929	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1080230001930	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
1080230001931	dimer interface [polypeptide binding]; other site
1080230001932	active site
1080230001933	motif 1; other site
1080230001934	motif 2; other site
1080230001935	motif 3; other site
1080230001936	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
1080230001937	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1080230001938	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
1080230001939	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1080230001940	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
1080230001941	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230001942	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230001943	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1080230001944	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1080230001945	active site
1080230001946	ATP binding site [chemical binding]; other site
1080230001947	substrate binding site [chemical binding]; other site
1080230001948	activation loop (A-loop); other site
1080230001949	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
1080230001950	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
1080230001951	active site
1080230001952	Zn binding site [ion binding]; other site
1080230001953	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
1080230001954	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
1080230001955	putative NADP binding site [chemical binding]; other site
1080230001956	putative substrate binding site [chemical binding]; other site
1080230001957	active site
1080230001958	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1080230001959	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
1080230001960	Peptidase family M23; Region: Peptidase_M23; pfam01551
1080230001961	DNA polymerase III subunit alpha; Reviewed; Region: PRK07373
1080230001962	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1080230001963	generic binding surface I; other site
1080230001964	generic binding surface II; other site
1080230001965	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230001966	phosphopeptide binding site; other site
1080230001967	Transglycosylase; Region: Transgly; cl07896
1080230001968	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1080230001969	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230001970	PAP_fibrillin; Region: PAP_fibrillin; pfam04755
1080230001971	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1080230001972	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
1080230001973	Walker A/P-loop; other site
1080230001974	ATP binding site [chemical binding]; other site
1080230001975	Q-loop/lid; other site
1080230001976	ABC transporter signature motif; other site
1080230001977	Walker B; other site
1080230001978	D-loop; other site
1080230001979	H-loop/switch region; other site
1080230001980	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1080230001981	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
1080230001982	Walker A/P-loop; other site
1080230001983	ATP binding site [chemical binding]; other site
1080230001984	Q-loop/lid; other site
1080230001985	ABC transporter signature motif; other site
1080230001986	Walker B; other site
1080230001987	D-loop; other site
1080230001988	H-loop/switch region; other site
1080230001989	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230001990	Uncharacterized integral membrane protein (DUF2301); Region: DUF2301; cl02241
1080230001991	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1080230001992	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
1080230001993	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230001994	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1080230001995	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
1080230001996	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230001997	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
1080230001998	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
1080230001999	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1080230002000	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1080230002001	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1080230002002	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1080230002003	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1080230002004	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230002005	ligand binding site [chemical binding]; other site
1080230002006	flexible hinge region; other site
1080230002007	Helix-turn-helix domains; Region: HTH; cl00088
1080230002008	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1080230002009	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1080230002010	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230002011	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
1080230002012	Walker A/P-loop; other site
1080230002013	ATP binding site [chemical binding]; other site
1080230002014	Q-loop/lid; other site
1080230002015	ABC transporter signature motif; other site
1080230002016	Walker B; other site
1080230002017	D-loop; other site
1080230002018	H-loop/switch region; other site
1080230002019	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
1080230002020	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1080230002021	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1080230002022	metal-binding site [ion binding]
1080230002023	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230002024	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230002025	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1080230002026	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1080230002027	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230002028	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230002029	active site
1080230002030	phosphorylation site [posttranslational modification]
1080230002031	intermolecular recognition site; other site
1080230002032	dimerization interface [polypeptide binding]; other site
1080230002033	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
1080230002034	coproporphyrinogen III oxidase; Provisional; Region: PRK07379
1080230002035	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1080230002036	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
1080230002037	active site
1080230002038	(T/H)XGH motif; other site
1080230002039	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1080230002040	active site
1080230002041	metal binding site [ion binding]; metal-binding site
1080230002042	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1080230002043	dihydropteroate synthase; Region: DHPS; TIGR01496
1080230002044	substrate binding pocket [chemical binding]; other site
1080230002045	dimer interface [polypeptide binding]; other site
1080230002046	inhibitor binding site; inhibition site
1080230002047	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1080230002048	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230002049	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1080230002050	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230002051	Exoribonuclease R [Transcription]; Region: VacB; COG0557
1080230002052	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1080230002053	RNB domain; Region: RNB; pfam00773
1080230002054	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
1080230002055	RNA binding site [nucleotide binding]; other site
1080230002056	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cd00136
1080230002057	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
1080230002058	Protein of unknown function (DUF512); Region: DUF512; pfam04459
1080230002059	GAF domain; Region: GAF; cl15785
1080230002060	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1080230002061	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1080230002062	argininosuccinate lyase; Provisional; Region: PRK00855
1080230002063	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1080230002064	active sites [active]
1080230002065	tetramer interface [polypeptide binding]; other site
1080230002066	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1080230002067	nudix motif; other site
1080230002068	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1080230002069	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
1080230002070	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1080230002071	B12 binding site [chemical binding]; other site
1080230002072	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230002073	FeS/SAM binding site; other site
1080230002074	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
1080230002075	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
1080230002076	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1080230002077	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1080230002078	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
1080230002079	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1080230002080	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1080230002081	D-pathway; other site
1080230002082	Putative ubiquinol binding site [chemical binding]; other site
1080230002083	Low-spin heme (heme b) binding site [chemical binding]; other site
1080230002084	Putative water exit pathway; other site
1080230002085	Binuclear center (heme o3/CuB) [ion binding]; other site
1080230002086	K-pathway; other site
1080230002087	Putative proton exit pathway; other site
1080230002088	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1080230002089	Subunit I/III interface [polypeptide binding]; other site
1080230002090	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1080230002091	catalytic residues [active]
1080230002092	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1080230002093	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1080230002094	inhibitor-cofactor binding pocket; inhibition site
1080230002095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230002096	catalytic residue [active]
1080230002097	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1080230002098	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
1080230002099	Walker A/P-loop; other site
1080230002100	ATP binding site [chemical binding]; other site
1080230002101	Q-loop/lid; other site
1080230002102	ABC transporter signature motif; other site
1080230002103	Walker B; other site
1080230002104	D-loop; other site
1080230002105	H-loop/switch region; other site
1080230002106	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1080230002107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230002108	dimer interface [polypeptide binding]; other site
1080230002109	conserved gate region; other site
1080230002110	putative PBP binding loops; other site
1080230002111	ABC-ATPase subunit interface; other site
1080230002112	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1080230002113	NMT1-like family; Region: NMT1_2; cl15260
1080230002114	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002115	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002116	G4 box; other site
1080230002117	G5 box; other site
1080230002118	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
1080230002119	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
1080230002120	Arginase family; Region: Arginase; cl00306
1080230002121	GAF domain; Region: GAF; cl15785
1080230002122	GAF domain; Region: GAF_2; pfam13185
1080230002123	GAF domain; Region: GAF_2; pfam13185
1080230002124	GAF domain; Region: GAF; cl15785
1080230002125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230002126	metal binding site [ion binding]; metal-binding site
1080230002127	active site
1080230002128	I-site; other site
1080230002129	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1080230002130	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
1080230002131	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230002132	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1080230002133	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230002134	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1080230002135	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1080230002136	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1080230002137	HIGH motif; other site
1080230002138	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1080230002139	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1080230002140	active site
1080230002141	KMSKS motif; other site
1080230002142	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1080230002143	tRNA binding surface [nucleotide binding]; other site
1080230002144	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
1080230002145	Protein of unknown function (DUF3155); Region: DUF3155; pfam11352
1080230002146	GAF domain; Region: GAF; cl15785
1080230002147	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230002148	dimer interface [polypeptide binding]; other site
1080230002149	phosphorylation site [posttranslational modification]
1080230002150	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230002151	ATP binding site [chemical binding]; other site
1080230002152	Mg2+ binding site [ion binding]; other site
1080230002153	G-X-G motif; other site
1080230002154	Domain of unknown function (DUF4269); Region: DUF4269; pfam14091
1080230002155	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1080230002156	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230002157	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
1080230002158	Walker A/P-loop; other site
1080230002159	ATP binding site [chemical binding]; other site
1080230002160	Q-loop/lid; other site
1080230002161	ABC transporter signature motif; other site
1080230002162	Walker B; other site
1080230002163	D-loop; other site
1080230002164	H-loop/switch region; other site
1080230002165	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230002166	putative active site [active]
1080230002167	Repair protein; Region: Repair_PSII; cl01535
1080230002168	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1080230002169	transketolase; Region: PLN02790
1080230002170	TPP-binding site [chemical binding]; other site
1080230002171	dimer interface [polypeptide binding]; other site
1080230002172	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1080230002173	PYR/PP interface [polypeptide binding]; other site
1080230002174	dimer interface [polypeptide binding]; other site
1080230002175	TPP binding site [chemical binding]; other site
1080230002176	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1080230002177	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1080230002178	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1080230002179	dimer interface [polypeptide binding]; other site
1080230002180	active site
1080230002181	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1080230002182	Protein of unknown function (DUF3148); Region: DUF3148; pfam11347
1080230002183	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1080230002184	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1080230002185	heme binding site [chemical binding]; other site
1080230002186	ferroxidase pore; other site
1080230002187	ferroxidase diiron center [ion binding]; other site
1080230002188	classical (c) SDRs; Region: SDR_c; cd05233
1080230002189	NAD(P) binding site [chemical binding]; other site
1080230002190	active site
1080230002191	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cl00787
1080230002192	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1080230002193	5S rRNA interface [nucleotide binding]; other site
1080230002194	CTC domain interface [polypeptide binding]; other site
1080230002195	L16 interface [polypeptide binding]; other site
1080230002196	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1080230002197	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1080230002198	GDP-binding site [chemical binding]; other site
1080230002199	ACT binding site; other site
1080230002200	IMP binding site; other site
1080230002201	Protein of unknown function (DUF2949); Region: DUF2949; pfam11165
1080230002202	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
1080230002203	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
1080230002204	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1080230002205	23S rRNA interface [nucleotide binding]; other site
1080230002206	L3 interface [polypeptide binding]; other site
1080230002207	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1080230002208	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1080230002209	dimerization interface 3.5A [polypeptide binding]; other site
1080230002210	active site
1080230002211	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
1080230002212	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1080230002213	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1080230002214	alphaNTD - beta interaction site [polypeptide binding]; other site
1080230002215	alphaNTD homodimer interface [polypeptide binding]; other site
1080230002216	alphaNTD - beta' interaction site [polypeptide binding]; other site
1080230002217	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
1080230002218	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
1080230002219	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
1080230002220	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1080230002221	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
1080230002222	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1080230002223	rRNA binding site [nucleotide binding]; other site
1080230002224	predicted 30S ribosome binding site; other site
1080230002225	adenylate kinase; Provisional; Region: adk; PRK02496
1080230002226	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1080230002227	AMP-binding site [chemical binding]; other site
1080230002228	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1080230002229	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1080230002230	SecY translocase; Region: SecY; pfam00344
1080230002231	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
1080230002232	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1080230002233	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1080230002234	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1080230002235	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1080230002236	5S rRNA interface [nucleotide binding]; other site
1080230002237	L27 interface [polypeptide binding]; other site
1080230002238	23S rRNA interface [nucleotide binding]; other site
1080230002239	L5 interface [polypeptide binding]; other site
1080230002240	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1080230002241	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1080230002242	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1080230002243	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
1080230002244	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1080230002245	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1080230002246	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1080230002247	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1080230002248	KOW motif; Region: KOW; cl00354
1080230002249	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
1080230002250	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
1080230002251	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1080230002252	23S rRNA interface [nucleotide binding]; other site
1080230002253	putative translocon interaction site; other site
1080230002254	signal recognition particle (SRP54) interaction site; other site
1080230002255	L23 interface [polypeptide binding]; other site
1080230002256	trigger factor interaction site; other site
1080230002257	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1080230002258	23S rRNA interface [nucleotide binding]; other site
1080230002259	5S rRNA interface [nucleotide binding]; other site
1080230002260	putative antibiotic binding site [chemical binding]; other site
1080230002261	L25 interface [polypeptide binding]; other site
1080230002262	L27 interface [polypeptide binding]; other site
1080230002263	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1080230002264	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1080230002265	G-X-X-G motif; other site
1080230002266	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1080230002267	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1080230002268	putative translocon binding site; other site
1080230002269	protein-rRNA interface [nucleotide binding]; other site
1080230002270	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
1080230002271	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1080230002272	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1080230002273	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1080230002274	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
1080230002275	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1080230002276	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
1080230002277	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1080230002278	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1080230002279	dimerization interface [polypeptide binding]; other site
1080230002280	DPS ferroxidase diiron center [ion binding]; other site
1080230002281	ion pore; other site
1080230002282	UTRA domain; Region: UTRA; cl01230
1080230002283	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1080230002284	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1080230002285	active site
1080230002286	metal binding site [ion binding]; metal-binding site
1080230002287	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1080230002288	active site
1080230002289	metal binding site [ion binding]; metal-binding site
1080230002290	Domain of unknown function (DUF1823); Region: DUF1823; pfam08853
1080230002291	Cytochrome c; Region: Cytochrom_C; cl11414
1080230002292	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1080230002293	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230002294	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1080230002295	feedback inhibition sensing region; other site
1080230002296	homohexameric interface [polypeptide binding]; other site
1080230002297	nucleotide binding site [chemical binding]; other site
1080230002298	N-acetyl-L-glutamate binding site [chemical binding]; other site
1080230002299	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1080230002300	UreF; Region: UreF; pfam01730
1080230002301	Protein of unknown function (DUF3386); Region: DUF3386; pfam11866
1080230002302	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1080230002303	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002304	Walker A/P-loop; other site
1080230002305	ATP binding site [chemical binding]; other site
1080230002306	Q-loop/lid; other site
1080230002307	ABC transporter signature motif; other site
1080230002308	Walker B; other site
1080230002309	D-loop; other site
1080230002310	H-loop/switch region; other site
1080230002311	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
1080230002312	Helix-turn-helix domains; Region: HTH; cl00088
1080230002313	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1080230002314	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
1080230002315	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230002316	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230002317	DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597
1080230002318	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1080230002319	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1080230002320	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1080230002321	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1080230002322	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1080230002323	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1080230002324	DNA binding site [nucleotide binding]
1080230002325	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1080230002326	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
1080230002327	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1080230002328	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1080230002329	RPB1 interaction site [polypeptide binding]; other site
1080230002330	RPB10 interaction site [polypeptide binding]; other site
1080230002331	RPB11 interaction site [polypeptide binding]; other site
1080230002332	RPB3 interaction site [polypeptide binding]; other site
1080230002333	RPB12 interaction site [polypeptide binding]; other site
1080230002334	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1080230002335	active site
1080230002336	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
1080230002337	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1080230002338	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1080230002339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230002340	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1080230002341	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230002342	putative active site [active]
1080230002343	heme pocket [chemical binding]; other site
1080230002344	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230002345	GAF domain; Region: GAF; cl15785
1080230002346	PAS domain S-box; Region: sensory_box; TIGR00229
1080230002347	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230002348	putative active site [active]
1080230002349	heme pocket [chemical binding]; other site
1080230002350	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1080230002351	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230002352	putative active site [active]
1080230002353	heme pocket [chemical binding]; other site
1080230002354	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230002355	dimer interface [polypeptide binding]; other site
1080230002356	phosphorylation site [posttranslational modification]
1080230002357	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230002358	ATP binding site [chemical binding]; other site
1080230002359	Mg2+ binding site [ion binding]; other site
1080230002360	G-X-G motif; other site
1080230002361	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1080230002362	Family description; Region: UvrD_C_2; cl15862
1080230002363	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
1080230002364	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
1080230002365	Walker A/P-loop; other site
1080230002366	ATP binding site [chemical binding]; other site
1080230002367	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; cl01201
1080230002368	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
1080230002369	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1080230002370	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
1080230002371	ABC transporter signature motif; other site
1080230002372	Walker B; other site
1080230002373	D-loop; other site
1080230002374	H-loop/switch region; other site
1080230002375	Phosphotransferase enzyme family; Region: APH; pfam01636
1080230002376	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230002377	active site
1080230002378	ATP binding site [chemical binding]; other site
1080230002379	tellurium resistance terB-like protein; Region: terB_like; cd07177
1080230002380	metal binding site [ion binding]; metal-binding site
1080230002381	Mo-dependent nitrogenase C-terminus; Region: Mo-nitro_C; pfam06967
1080230002382	Protein of unknown function (DUF3531); Region: DUF3531; pfam12049
1080230002383	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1080230002384	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1080230002385	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1080230002386	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1080230002387	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
1080230002388	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1080230002389	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1080230002390	dimer interface [polypeptide binding]; other site
1080230002391	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1080230002392	catalytic triad [active]
1080230002393	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
1080230002394	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230002395	ATP binding site [chemical binding]; other site
1080230002396	Mg2+ binding site [ion binding]; other site
1080230002397	G-X-G motif; other site
1080230002398	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1080230002399	ATP binding site [chemical binding]; other site
1080230002400	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
1080230002401	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1080230002402	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1080230002403	TM-ABC transporter signature motif; other site
1080230002404	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1080230002405	TM-ABC transporter signature motif; other site
1080230002406	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
1080230002407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230002408	dimer interface [polypeptide binding]; other site
1080230002409	putative PBP binding loops; other site
1080230002410	ABC-ATPase subunit interface; other site
1080230002411	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230002412	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1080230002413	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1080230002414	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1080230002415	protein binding site [polypeptide binding]; other site
1080230002416	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1080230002417	iron-sulfur cluster [ion binding]; other site
1080230002418	[2Fe-2S] cluster binding site [ion binding]; other site
1080230002419	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
1080230002420	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1080230002421	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230002422	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1080230002423	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230002424	short chain dehydrogenase; Validated; Region: PRK08324
1080230002425	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1080230002426	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
1080230002427	putative NAD(P) binding site [chemical binding]; other site
1080230002428	active site
1080230002429	Protein of unknown function (DUF433); Region: DUF433; cl01030
1080230002430	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
1080230002431	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1080230002432	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1080230002433	Serpentine type 7TM GPCR chemoreceptor Srh; Region: 7TM_GPCR_Srh; cl11665
1080230002434	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1080230002435	PAS domain S-box; Region: sensory_box; TIGR00229
1080230002436	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230002437	putative active site [active]
1080230002438	heme pocket [chemical binding]; other site
1080230002439	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230002440	PAS fold; Region: PAS_3; pfam08447
1080230002441	putative active site [active]
1080230002442	heme pocket [chemical binding]; other site
1080230002443	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230002444	GAF domain; Region: GAF; cl15785
1080230002445	Histidine kinase; Region: HisKA_2; cl06527
1080230002446	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230002447	ATP binding site [chemical binding]; other site
1080230002448	Mg2+ binding site [ion binding]; other site
1080230002449	G-X-G motif; other site
1080230002450	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230002451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230002452	active site
1080230002453	phosphorylation site [posttranslational modification]
1080230002454	intermolecular recognition site; other site
1080230002455	dimerization interface [polypeptide binding]; other site
1080230002456	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1080230002457	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1080230002458	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1080230002459	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230002460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230002461	active site
1080230002462	phosphorylation site [posttranslational modification]
1080230002463	intermolecular recognition site; other site
1080230002464	dimerization interface [polypeptide binding]; other site
1080230002465	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1080230002466	trimer interface [polypeptide binding]; other site
1080230002467	active site
1080230002468	dimer interface [polypeptide binding]; other site
1080230002469	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
1080230002470	MgtE intracellular N domain; Region: MgtE_N; cl15244
1080230002471	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1080230002472	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1080230002473	Divalent cation transporter; Region: MgtE; cl00786
1080230002474	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230002475	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1080230002476	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230002477	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1080230002478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1080230002479	TRAM domain; Region: TRAM; cl01282
1080230002480	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1080230002481	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230002482	S-adenosylmethionine binding site [chemical binding]; other site
1080230002483	threonine dehydratase; Reviewed; Region: PRK09224
1080230002484	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1080230002485	tetramer interface [polypeptide binding]; other site
1080230002486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230002487	catalytic residue [active]
1080230002488	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1080230002489	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1080230002490	putative Ile/Val binding site [chemical binding]; other site
1080230002491	Protein of unknown function (DUF552); Region: DUF552; cl00775
1080230002492	Cupin domain; Region: Cupin_2; cl09118
1080230002493	Protein of unknown function (DUF497); Region: DUF497; cl01108
1080230002494	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1080230002495	oligomerisation interface [polypeptide binding]; other site
1080230002496	mobile loop; other site
1080230002497	roof hairpin; other site
1080230002498	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1080230002499	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1080230002500	ring oligomerisation interface [polypeptide binding]; other site
1080230002501	ATP/Mg binding site [chemical binding]; other site
1080230002502	stacking interactions; other site
1080230002503	hinge regions; other site
1080230002504	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1080230002505	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230002506	substrate binding pocket [chemical binding]; other site
1080230002507	membrane-bound complex binding site; other site
1080230002508	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230002509	metal binding site [ion binding]; metal-binding site
1080230002510	active site
1080230002511	I-site; other site
1080230002512	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230002513	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1080230002514	dimer interface [polypeptide binding]; other site
1080230002515	ADP-ribose binding site [chemical binding]; other site
1080230002516	active site
1080230002517	nudix motif; other site
1080230002518	metal binding site [ion binding]; metal-binding site
1080230002519	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1080230002520	Tetramer interface [polypeptide binding]; other site
1080230002521	active site
1080230002522	FMN-binding site [chemical binding]; other site
1080230002523	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1080230002524	L11 interface [polypeptide binding]; other site
1080230002525	putative EF-Tu interaction site [polypeptide binding]; other site
1080230002526	putative EF-G interaction site [polypeptide binding]; other site
1080230002527	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1080230002528	23S rRNA interface [nucleotide binding]; other site
1080230002529	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1080230002530	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1080230002531	mRNA/rRNA interface [nucleotide binding]; other site
1080230002532	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1080230002533	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1080230002534	23S rRNA interface [nucleotide binding]; other site
1080230002535	L7/L12 interface [polypeptide binding]; other site
1080230002536	putative thiostrepton binding site; other site
1080230002537	L25 interface [polypeptide binding]; other site
1080230002538	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1080230002539	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1080230002540	putative homodimer interface [polypeptide binding]; other site
1080230002541	KOW motif; Region: KOW; cl00354
1080230002542	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
1080230002543	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
1080230002544	hydrolase, alpha/beta fold family protein; Region: PLN02824
1080230002545	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230002546	Late competence development protein ComFB; Region: ComFB; pfam10719
1080230002547	Peptidase family M41; Region: Peptidase_M41; pfam01434
1080230002548	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
1080230002549	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230002550	catalytic loop [active]
1080230002551	iron binding site [ion binding]; other site
1080230002552	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E); Region: PHA_synth_III_E; cl09914
1080230002553	poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit; Region: PHA_synth_III_C; TIGR01836
1080230002554	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1080230002555	Fasciclin domain; Region: Fasciclin; cl02663
1080230002556	CO2 hydration protein (ChpXY); Region: ChpXY; cl10905
1080230002557	NAD(P)H-quinone oxidoreductase subunit M; Validated; Region: PRK07363
1080230002558	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230002559	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
1080230002560	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230002561	Protein of unknown function (DUF3540); Region: DUF3540; pfam12059
1080230002562	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
1080230002563	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
1080230002564	Phosphotransferase enzyme family; Region: APH; pfam01636
1080230002565	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230002566	substrate binding site [chemical binding]; other site
1080230002567	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230002568	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1080230002569	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002570	Walker A/P-loop; other site
1080230002571	ATP binding site [chemical binding]; other site
1080230002572	Q-loop/lid; other site
1080230002573	ABC transporter signature motif; other site
1080230002574	Walker B; other site
1080230002575	D-loop; other site
1080230002576	H-loop/switch region; other site
1080230002577	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230002578	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1080230002579	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1080230002580	putative ADP-binding pocket [chemical binding]; other site
1080230002581	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
1080230002582	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230002583	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230002584	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230002585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230002586	active site
1080230002587	phosphorylation site [posttranslational modification]
1080230002588	intermolecular recognition site; other site
1080230002589	dimerization interface [polypeptide binding]; other site
1080230002590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230002591	DNA binding site [nucleotide binding]
1080230002592	pyruvate dehydrogenase E1 component beta subunit; Validated; Region: odpB; CHL00144
1080230002593	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1080230002594	alpha subunit interface [polypeptide binding]; other site
1080230002595	TPP binding site [chemical binding]; other site
1080230002596	heterodimer interface [polypeptide binding]; other site
1080230002597	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1080230002598	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1080230002599	Hexamer interface [polypeptide binding]; other site
1080230002600	Hexagonal pore residue; other site
1080230002601	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1080230002602	Hexamer interface [polypeptide binding]; other site
1080230002603	Hexagonal pore residue; other site
1080230002604	Glycerate kinase family; Region: Gly_kinase; cl00841
1080230002605	S-layer homology domain; Region: SLH; pfam00395
1080230002606	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230002607	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230002608	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1080230002609	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1080230002610	dimer interface [polypeptide binding]; other site
1080230002611	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230002612	catalytic residue [active]
1080230002613	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1080230002614	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1080230002615	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1080230002616	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1080230002617	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
1080230002618	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
1080230002619	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
1080230002620	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230002621	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230002622	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230002623	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230002624	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1080230002625	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1080230002626	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230002627	homodimer interface [polypeptide binding]; other site
1080230002628	catalytic residue [active]
1080230002629	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1080230002630	IHF dimer interface [polypeptide binding]; other site
1080230002631	IHF - DNA interface [nucleotide binding]; other site
1080230002632	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230002633	Coenzyme A binding pocket [chemical binding]; other site
1080230002634	Uncharacterized subfamily of  glycoside hydrolase family 57 (GH57); Region: GH57N_like_1; cd10798
1080230002635	active site
1080230002636	catalytic site [active]
1080230002637	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230002638	ATP binding site [chemical binding]; other site
1080230002639	putative Mg++ binding site [ion binding]; other site
1080230002640	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1080230002641	nucleotide binding region [chemical binding]; other site
1080230002642	ATP-binding site [chemical binding]; other site
1080230002643	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1080230002644	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1080230002645	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1080230002646	active site
1080230002647	CbiD; Region: CbiD; cl00828
1080230002648	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1080230002649	atypical (a) SDRs, subgroup 1; Region: SDR_a1; cd05265
1080230002650	putative NAD(P) binding site [chemical binding]; other site
1080230002651	active site
1080230002652	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1080230002653	homotrimer interaction site [polypeptide binding]; other site
1080230002654	zinc binding site [ion binding]; other site
1080230002655	CDP-binding sites; other site
1080230002656	putative efflux protein, MATE family; Region: matE; TIGR00797
1080230002657	MatE; Region: MatE; cl10513
1080230002658	MatE; Region: MatE; cl10513
1080230002659	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1080230002660	Beta-carotene hydroxylase (CrtR), the carotenoid zeaxanthin biosynthetic enzyme catalyzes the addition of hydroxyl groups to the beta-ionone rings of beta-carotene to form zeaxanthin and is found in bacteria and red algae. Carotenoids are important...; Region: CrtR_beta-carotene-hydroxylase; cd03514
1080230002661	putative di-iron ligands [ion binding]; other site
1080230002662	light-harvesting-like protein 3; Provisional; Region: PLN00014
1080230002663	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1080230002664	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230002665	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230002666	DNA binding residues [nucleotide binding]
1080230002667	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1080230002668	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
1080230002669	Predicted permease; Region: DUF318; pfam03773
1080230002670	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230002671	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
1080230002672	putative ADP-binding pocket [chemical binding]; other site
1080230002673	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1080230002674	Uncharacterized conserved protein [Function unknown]; Region: COG0397; cl00428
1080230002675	Uncharacterized ACR, YdiU/UPF0061 family; Region: UPF0061; pfam02696
1080230002676	FtsH Extracellular; Region: FtsH_ext; pfam06480
1080230002677	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1080230002678	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230002679	Walker A motif; other site
1080230002680	ATP binding site [chemical binding]; other site
1080230002681	Walker B motif; other site
1080230002682	arginine finger; other site
1080230002683	Peptidase family M41; Region: Peptidase_M41; pfam01434
1080230002684	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
1080230002685	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
1080230002686	dimerization interface [polypeptide binding]; other site
1080230002687	ATP binding site [chemical binding]; other site
1080230002688	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230002689	putative active site [active]
1080230002690	Survival protein SurE; Region: SurE; cl00448
1080230002691	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1080230002692	active site
1080230002693	catalytic residues [active]
1080230002694	metal binding site [ion binding]; metal-binding site
1080230002695	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1080230002696	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1080230002697	dimer interface [polypeptide binding]; other site
1080230002698	putative anticodon binding site; other site
1080230002699	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1080230002700	motif 1; other site
1080230002701	active site
1080230002702	motif 2; other site
1080230002703	motif 3; other site
1080230002704	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
1080230002705	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1080230002706	Ligand binding site; other site
1080230002707	Putative Catalytic site; other site
1080230002708	DXD motif; other site
1080230002709	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230002710	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230002711	Conserved nitrate reductase-associated protein (Nitr_red_assoc); Region: Nitr_red_assoc; cl09869
1080230002712	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1080230002713	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1080230002714	[4Fe-4S] binding site [ion binding]; other site
1080230002715	molybdopterin cofactor binding site; other site
1080230002716	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
1080230002717	molybdopterin cofactor binding site; other site
1080230002718	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
1080230002719	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1080230002720	Walker A/P-loop; other site
1080230002721	ATP binding site [chemical binding]; other site
1080230002722	Q-loop/lid; other site
1080230002723	ABC transporter signature motif; other site
1080230002724	Walker B; other site
1080230002725	D-loop; other site
1080230002726	H-loop/switch region; other site
1080230002727	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
1080230002728	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1080230002729	Walker A/P-loop; other site
1080230002730	ATP binding site [chemical binding]; other site
1080230002731	Q-loop/lid; other site
1080230002732	ABC transporter signature motif; other site
1080230002733	Walker B; other site
1080230002734	D-loop; other site
1080230002735	H-loop/switch region; other site
1080230002736	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1080230002737	NMT1-like family; Region: NMT1_2; cl15260
1080230002738	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1080230002739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230002740	ABC-ATPase subunit interface; other site
1080230002741	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1080230002742	NMT1-like family; Region: NMT1_2; cl15260
1080230002743	hypothetical protein; Provisional; Region: PRK07394
1080230002744	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1080230002745	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1080230002746	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1080230002747	catalytic core [active]
1080230002748	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
1080230002749	cell division protein FtsZ; Validated; Region: PRK09330
1080230002750	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1080230002751	nucleotide binding site [chemical binding]; other site
1080230002752	SulA interaction site; other site
1080230002753	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
1080230002754	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1080230002755	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1080230002756	C-terminal peptidase (prc); Region: prc; TIGR00225
1080230002757	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1080230002758	protein binding site [polypeptide binding]; other site
1080230002759	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1080230002760	Catalytic dyad [active]
1080230002761	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230002762	putative active site [active]
1080230002763	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230002764	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1080230002765	Domain of unknown function (DUF4168); Region: DUF4168; pfam13767
1080230002766	Urease accessory protein UreE [Posttranslational modification, protein turnover, chaperones]; Region: UreE; COG2371
1080230002767	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1080230002768	dimer interface [polypeptide binding]; other site
1080230002769	catalytic residues [active]
1080230002770	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
1080230002771	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1080230002772	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002773	Family description; Region: UvrD_C_2; cl15862
1080230002774	Bifunctional nuclease; Region: DNase-RNase; cl00553
1080230002775	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
1080230002776	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
1080230002777	putative NAD(P) binding site [chemical binding]; other site
1080230002778	putative active site [active]
1080230002779	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1080230002780	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
1080230002781	Walker A/P-loop; other site
1080230002782	ATP binding site [chemical binding]; other site
1080230002783	Q-loop/lid; other site
1080230002784	ABC transporter signature motif; other site
1080230002785	Walker B; other site
1080230002786	D-loop; other site
1080230002787	H-loop/switch region; other site
1080230002788	TOBE domain; Region: TOBE_2; cl01440
1080230002789	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1080230002790	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1080230002791	active site
1080230002792	ATP binding site [chemical binding]; other site
1080230002793	substrate binding site [chemical binding]; other site
1080230002794	activation loop (A-loop); other site
1080230002795	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1080230002796	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230002797	motif II; other site
1080230002798	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1080230002799	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1080230002800	ATP binding site [chemical binding]; other site
1080230002801	active site
1080230002802	substrate binding site [chemical binding]; other site
1080230002803	chloroplast envelope protein translocase, IAP75 family; Region: 3a0901s03IAP75; TIGR00992
1080230002804	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
1080230002805	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
1080230002806	Surface antigen; Region: Bac_surface_Ag; cl03097
1080230002807	peptide chain release factor 3; Region: prfC; TIGR00503
1080230002808	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1080230002809	G1 box; other site
1080230002810	putative GEF interaction site [polypeptide binding]; other site
1080230002811	GTP/Mg2+ binding site [chemical binding]; other site
1080230002812	Switch I region; other site
1080230002813	G2 box; other site
1080230002814	G3 box; other site
1080230002815	Switch II region; other site
1080230002816	G4 box; other site
1080230002817	G5 box; other site
1080230002818	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1080230002819	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1080230002820	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230002821	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230002822	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1080230002823	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230002824	Ligand Binding Site [chemical binding]; other site
1080230002825	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230002826	Ligand Binding Site [chemical binding]; other site
1080230002827	Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380
1080230002828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230002829	Bacterial SH3 domain; Region: SH3_3; cl02551
1080230002830	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK05945
1080230002831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230002832	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1080230002833	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
1080230002834	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1080230002835	nucleotide binding site/active site [active]
1080230002836	HIT family signature motif; other site
1080230002837	catalytic residue [active]
1080230002838	hydrolase; Region: PLN02578
1080230002839	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230002840	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
1080230002841	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
1080230002842	GtrA-like protein; Region: GtrA; cl00971
1080230002843	cytosine deaminase-like protein; Validated; Region: PRK07583
1080230002844	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1080230002845	active site
1080230002846	PemK-like protein; Region: PemK; cl00995
1080230002847	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230002848	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230002849	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1080230002850	GSH binding site [chemical binding]; other site
1080230002851	catalytic residues [active]
1080230002852	glutathione synthetase, prokaryotic; Region: glut_syn; TIGR01380
1080230002853	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1080230002854	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230002855	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
1080230002856	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1080230002857	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
1080230002858	substrate binding site [chemical binding]; other site
1080230002859	oxyanion hole (OAH) forming residues; other site
1080230002860	trimer interface [polypeptide binding]; other site
1080230002861	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1080230002862	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
1080230002863	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230002864	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1080230002865	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1080230002866	active site
1080230002867	NTP binding site [chemical binding]; other site
1080230002868	metal binding triad [ion binding]; metal-binding site
1080230002869	antibiotic binding site [chemical binding]; other site
1080230002870	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230002871	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
1080230002872	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1080230002873	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
1080230002874	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
1080230002875	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230002876	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1080230002877	Galactose mutarotase and related enzymes [Carbohydrate transport and metabolism]; Region: GalM; COG2017
1080230002878	Aldose 1-epimerase, similar to Synechocystis Slr1438; Region: Aldose_epim_Slr1438; cd09025
1080230002879	active site
1080230002880	catalytic residues [active]
1080230002881	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1080230002882	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1080230002883	HIGH motif; other site
1080230002884	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1080230002885	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1080230002886	active site
1080230002887	KMSKS motif; other site
1080230002888	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1080230002889	tRNA binding surface [nucleotide binding]; other site
1080230002890	anticodon binding site; other site
1080230002891	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1080230002892	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230002893	Walker A motif; other site
1080230002894	ATP binding site [chemical binding]; other site
1080230002895	Walker B motif; other site
1080230002896	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1080230002897	protein-splicing catalytic site; other site
1080230002898	thioester formation/cholesterol transfer; other site
1080230002899	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1080230002900	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1080230002901	protein-splicing catalytic site; other site
1080230002902	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14948
1080230002903	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002904	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1080230002905	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1080230002906	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1080230002907	active site
1080230002908	metal binding site [ion binding]; metal-binding site
1080230002909	Cytochrome c [Energy production and conversion]; Region: COG3258
1080230002910	Cytochrome c; Region: Cytochrom_C; cl11414
1080230002911	Cupin domain; Region: Cupin_2; cl09118
1080230002912	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
1080230002913	Cupin domain; Region: Cupin_2; cl09118
1080230002914	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1080230002915	homodimer interface [polypeptide binding]; other site
1080230002916	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1080230002917	active site pocket [active]
1080230002918	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230002919	putative active site [active]
1080230002920	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
1080230002921	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1080230002922	active site
1080230002923	ATP binding site [chemical binding]; other site
1080230002924	substrate binding site [chemical binding]; other site
1080230002925	activation loop (A-loop); other site
1080230002926	CHAD domain; Region: CHAD; cl10506
1080230002927	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1080230002928	DHH family; Region: DHH; pfam01368
1080230002929	DHHA1 domain; Region: DHHA1; pfam02272
1080230002930	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230002931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230002932	dimer interface [polypeptide binding]; other site
1080230002933	phosphorylation site [posttranslational modification]
1080230002934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230002935	ATP binding site [chemical binding]; other site
1080230002936	Mg2+ binding site [ion binding]; other site
1080230002937	G-X-G motif; other site
1080230002938	Predicted membrane protein [Function unknown]; Region: COG3463
1080230002939	Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852
1080230002940	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1080230002941	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1080230002942	putative substrate binding site [chemical binding]; other site
1080230002943	putative ATP binding site [chemical binding]; other site
1080230002944	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1080230002945	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1080230002946	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230002947	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1080230002948	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230002949	motif II; other site
1080230002950	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230002951	iron-sulfur cluster binding protein, putative; Region: TIGR00276
1080230002952	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1080230002953	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1080230002954	homopentamer interface [polypeptide binding]; other site
1080230002955	active site
1080230002956	Region: Ycf9; cl09269
1080230002957	Peptidase family M48; Region: Peptidase_M48; cl12018
1080230002958	30S ribosomal protein S1; Reviewed; Region: PRK07400
1080230002959	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1080230002960	RNA binding site [nucleotide binding]; other site
1080230002961	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1080230002962	RNA binding site [nucleotide binding]; other site
1080230002963	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
1080230002964	RNA binding site [nucleotide binding]; other site
1080230002965	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230002966	Helix-turn-helix domains; Region: HTH; cl00088
1080230002967	Integrase core domain; Region: rve; cl01316
1080230002968	recombination protein F; Reviewed; Region: recF; PRK00064
1080230002969	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
1080230002970	Walker A/P-loop; other site
1080230002971	ATP binding site [chemical binding]; other site
1080230002972	Q-loop/lid; other site
1080230002973	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002974	ABC transporter signature motif; other site
1080230002975	Walker B; other site
1080230002976	D-loop; other site
1080230002977	H-loop/switch region; other site
1080230002978	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1080230002979	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230002980	MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251
1080230002981	Walker A/P-loop; other site
1080230002982	ATP binding site [chemical binding]; other site
1080230002983	Q-loop/lid; other site
1080230002984	ABC transporter signature motif; other site
1080230002985	Walker B; other site
1080230002986	D-loop; other site
1080230002987	H-loop/switch region; other site
1080230002988	pyruvate kinase; Provisional; Region: PRK06354
1080230002989	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
1080230002990	domain interfaces; other site
1080230002991	active site
1080230002992	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
1080230002993	Domain of unknown function (DUF1824); Region: DUF1824; pfam08854
1080230002994	Protein of unknown function (DUF2396); Region: DUF2396; cl09868
1080230002995	polyphosphate:AMP phosphotransferase; Region: poly_P_AMP_trns; TIGR03708
1080230002996	Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971
1080230002997	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230002998	active site
1080230002999	biotin synthase; Region: bioB; TIGR00433
1080230003000	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230003001	FeS/SAM binding site; other site
1080230003002	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
1080230003003	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
1080230003004	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1080230003005	lipoprotein signal peptidase; Provisional; Region: PRK14787
1080230003006	Domain of unknown function (DUF4393); Region: DUF4393; pfam14337
1080230003007	S-layer homology domain; Region: SLH; pfam00395
1080230003008	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230003009	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1080230003010	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230003011	substrate binding pocket [chemical binding]; other site
1080230003012	membrane-bound complex binding site; other site
1080230003013	hinge residues; other site
1080230003014	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1080230003015	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230003016	dimer interface [polypeptide binding]; other site
1080230003017	conserved gate region; other site
1080230003018	putative PBP binding loops; other site
1080230003019	ABC-ATPase subunit interface; other site
1080230003020	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
1080230003021	homodimer interface [polypeptide binding]; other site
1080230003022	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1080230003023	active site pocket [active]
1080230003024	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
1080230003025	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230003026	S-adenosylmethionine binding site [chemical binding]; other site
1080230003027	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
1080230003028	Family of unknown function (DUF490); Region: DUF490; pfam04357
1080230003029	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
1080230003030	Holliday junction DNA helicase, RuvA subunit; Region: ruvA; TIGR00084
1080230003031	RuvA N terminal domain; Region: RuvA_N; pfam01330
1080230003032	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1080230003033	Integral membrane protein DUF92; Region: DUF92; cl00793
1080230003034	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1080230003035	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
1080230003036	RNA/DNA binding site [nucleotide binding]; other site
1080230003037	RRM dimerization site [polypeptide binding]; other site
1080230003038	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1080230003039	Amidase; Region: Amidase; cl11426
1080230003040	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1080230003041	Peptidase family M23; Region: Peptidase_M23; pfam01551
1080230003042	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1080230003043	lipoyl attachment site [posttranslational modification]; other site
1080230003044	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1080230003045	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1080230003046	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
1080230003047	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
1080230003048	dimer interface [polypeptide binding]; other site
1080230003049	active site
1080230003050	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1080230003051	catalytic residues [active]
1080230003052	substrate binding site [chemical binding]; other site
1080230003053	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1080230003054	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1080230003055	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1080230003056	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1080230003057	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230003058	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1080230003059	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
1080230003060	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230003061	putative active site [active]
1080230003062	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230003063	lipoyl synthase; Provisional; Region: PRK12928
1080230003064	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230003065	FeS/SAM binding site; other site
1080230003066	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1080230003067	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1080230003068	active site
1080230003069	catalytic tetrad [active]
1080230003070	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1080230003071	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1080230003072	NAD(P) binding site [chemical binding]; other site
1080230003073	homotetramer interface [polypeptide binding]; other site
1080230003074	homodimer interface [polypeptide binding]; other site
1080230003075	active site
1080230003076	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449
1080230003077	homodimer interface [polypeptide binding]; other site
1080230003078	substrate-cofactor binding pocket; other site
1080230003079	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230003080	catalytic residue [active]
1080230003081	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230003082	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
1080230003083	active site
1080230003084	ATP binding site [chemical binding]; other site
1080230003085	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
1080230003086	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1080230003087	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1080230003088	GIY-YIG motif/motif A; other site
1080230003089	active site
1080230003090	catalytic site [active]
1080230003091	putative DNA binding site [nucleotide binding]; other site
1080230003092	metal binding site [ion binding]; metal-binding site
1080230003093	UvrB/uvrC motif; Region: UVR; pfam02151
1080230003094	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1080230003095	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1080230003096	Bacterial SH3 domain; Region: SH3_3; cl02551
1080230003097	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1080230003098	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1080230003099	active site
1080230003100	metal binding site [ion binding]; metal-binding site
1080230003101	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
1080230003102	MPN+ (JAMM) motif; other site
1080230003103	Zinc-binding site [ion binding]; other site
1080230003104	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1080230003105	active site
1080230003106	putative substrate binding region [chemical binding]; other site
1080230003107	N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274
1080230003108	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1080230003109	putative active site [active]
1080230003110	Protein of unknown function (DUF3110); Region: DUF3110; pfam11360
1080230003111	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
1080230003112	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
1080230003113	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1080230003114	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1080230003115	Photosystem II 10 kDa phosphoprotein; Region: PsbH; cl02951
1080230003116	Photosystem II reaction centre N protein (psbN); Region: PsbN; cl03605
1080230003117	YCII-related domain; Region: YCII; cl00999
1080230003118	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1080230003119	structural tetrad; other site
1080230003120	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1080230003121	BNR repeat-like domain; Region: BNR_2; pfam13088
1080230003122	Calx-beta domain; Region: Calx-beta; cl02522
1080230003123	FG-GAP repeat; Region: FG-GAP; cl15299
1080230003124	FG-GAP repeat; Region: FG-GAP; cl15299
1080230003125	FG-GAP repeat; Region: FG-GAP; cl15299
1080230003126	FG-GAP repeat; Region: FG-GAP; cl15299
1080230003127	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230003128	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230003129	classical (c) SDR, subgroup 7; Region: SDR_c7; cd05354
1080230003130	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745
1080230003131	putative NAD(P) binding site [chemical binding]; other site
1080230003132	active site
1080230003133	Domain of unknown function (DUF336); Region: DUF336; cl01249
1080230003134	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1080230003135	structural tetrad; other site
1080230003136	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1080230003137	structural tetrad; other site
1080230003138	Domain of unknown function (DUF336); Region: DUF336; cl01249
1080230003139	Putative catalytic domain of Synechocystis sp. Sll1306 protein and other bacterial homologs; Region: CE4_Sll1306_like; cd10978
1080230003140	putative active site [active]
1080230003141	putative catalytic site [active]
1080230003142	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230003143	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230003144	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1080230003145	Thermophilic glucose-6-phosphate isomerase and related metalloenzymes [Carbohydrate transport and metabolism / General function prediction only]; Region: COG2140
1080230003146	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1080230003147	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1080230003148	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1080230003149	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1080230003150	conserved cys residue [active]
1080230003151	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1080230003152	dimerization interface [polypeptide binding]; other site
1080230003153	putative active cleft [active]
1080230003154	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1080230003155	anti sigma factor interaction site; other site
1080230003156	regulatory phosphorylation site [posttranslational modification]; other site
1080230003157	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
1080230003158	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme; Region: E_set_GDE_N; cd11234
1080230003159	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
1080230003160	active site
1080230003161	catalytic site [active]
1080230003162	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1080230003163	anti sigma factor interaction site; other site
1080230003164	regulatory phosphorylation site [posttranslational modification]; other site
1080230003165	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1080230003166	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1080230003167	dimerization interface [polypeptide binding]; other site
1080230003168	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1080230003169	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1080230003170	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1080230003171	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1080230003172	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1080230003173	Membrane transport protein; Region: Mem_trans; cl09117
1080230003174	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1080230003175	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230003176	Cache domain; Region: Cache_1; pfam02743
1080230003177	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1080230003178	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1080230003179	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1080230003180	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1080230003181	intersubunit interface [polypeptide binding]; other site
1080230003182	active site
1080230003183	catalytic residue [active]
1080230003184	Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354
1080230003185	beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215
1080230003186	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
1080230003187	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1080230003188	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1080230003189	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
1080230003190	putative metal binding site [ion binding]; other site
1080230003191	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
1080230003192	Cupin domain; Region: Cupin_2; cl09118
1080230003193	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1080230003194	Helix-turn-helix domains; Region: HTH; cl00088
1080230003195	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1080230003196	putative effector binding pocket; other site
1080230003197	dimerization interface [polypeptide binding]; other site
1080230003198	MutS2 family protein; Region: mutS2; TIGR01069
1080230003199	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
1080230003200	Walker A/P-loop; other site
1080230003201	ATP binding site [chemical binding]; other site
1080230003202	Q-loop/lid; other site
1080230003203	ABC transporter signature motif; other site
1080230003204	Walker B; other site
1080230003205	D-loop; other site
1080230003206	H-loop/switch region; other site
1080230003207	Smr domain; Region: Smr; cl02619
1080230003208	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1080230003209	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1080230003210	active site
1080230003211	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1080230003212	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230003213	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230003214	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1080230003215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230003216	dimer interface [polypeptide binding]; other site
1080230003217	conserved gate region; other site
1080230003218	putative PBP binding loops; other site
1080230003219	ABC-ATPase subunit interface; other site
1080230003220	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1080230003221	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1080230003222	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230003223	Exopolysaccharide synthesis, ExoD; Region: ExoD; cl01617
1080230003224	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
1080230003225	Endopeptidases that belong to the bidirectional NAD-linked hydrogenase group. This group of endopeptidases are highly specific carboxyl-terminal protease (HoxW protease) which releases a 24-amino-acid peptide from HoxH prior to progression of subunit...; Region: H2MP_NAD-link-bidir; cd06066
1080230003226	nickel binding site [ion binding]; other site
1080230003227	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
1080230003228	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1080230003229	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1080230003230	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1080230003231	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
1080230003232	radical SAM/SPASM domain protein, GRRM system; Region: rSAM_GlyRichRpt; TIGR04261
1080230003233	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230003234	FeS/SAM binding site; other site
1080230003235	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
1080230003236	rSAM-associated Gly-rich repeat protein; Region: Cyano_gly_rpt; TIGR04260
1080230003237	extracellular substrate-binding orphan protein, GRRM family; Region: orph_peri_GRRM; TIGR04262
1080230003238	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230003239	substrate binding pocket [chemical binding]; other site
1080230003240	membrane-bound complex binding site; other site
1080230003241	hinge residues; other site
1080230003242	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
1080230003243	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
1080230003244	Bacterial protein of unknown function (DUF922); Region: DUF922; cl02415
1080230003245	homoserine kinase; Region: thrB; TIGR00191
1080230003246	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1080230003247	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1080230003248	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230003249	Phosphotransferase enzyme family; Region: APH; pfam01636
1080230003250	active site
1080230003251	substrate binding site [chemical binding]; other site
1080230003252	ATP binding site [chemical binding]; other site
1080230003253	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14317
1080230003254	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1080230003255	active site
1080230003256	substrate binding site [chemical binding]; other site
1080230003257	metal binding site [ion binding]; metal-binding site
1080230003258	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
1080230003259	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1080230003260	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
1080230003261	Walker A/P-loop; other site
1080230003262	ATP binding site [chemical binding]; other site
1080230003263	Q-loop/lid; other site
1080230003264	ABC transporter signature motif; other site
1080230003265	Walker B; other site
1080230003266	D-loop; other site
1080230003267	H-loop/switch region; other site
1080230003268	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1080230003269	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1080230003270	active site
1080230003271	Riboflavin kinase; Region: Flavokinase; cl03312
1080230003272	Phage minor structural protein GP20; Region: Phage_GP20; pfam06810
1080230003273	Protein of unknown function (DUF3143); Region: DUF3143; pfam11341
1080230003274	CP12 domain; Region: CP12; cl14670
1080230003275	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1080230003276	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1080230003277	active site
1080230003278	HIGH motif; other site
1080230003279	dimer interface [polypeptide binding]; other site
1080230003280	KMSKS motif; other site
1080230003281	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
1080230003282	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1080230003283	Oligomerisation domain; Region: Oligomerisation; cl00519
1080230003284	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1080230003285	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1080230003286	domain interfaces; other site
1080230003287	active site
1080230003288	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
1080230003289	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
1080230003290	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1080230003291	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
1080230003292	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1080230003293	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230003294	phosphate acetyltransferase; Reviewed; Region: PRK05632
1080230003295	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230003296	DRTGG domain; Region: DRTGG; cl12147
1080230003297	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
1080230003298	Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493
1080230003299	Sugar fermentation stimulation protein; Region: SfsA; cl00647
1080230003300	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
1080230003301	RNA polymerase sigma factor SigD; Validated; Region: PRK07405
1080230003302	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1080230003303	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230003304	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1080230003305	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230003306	DNA binding residues [nucleotide binding]
1080230003307	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
1080230003308	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1080230003309	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02705
1080230003310	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1080230003311	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1080230003312	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1080230003313	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1080230003314	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1080230003315	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1080230003316	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1080230003317	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1080230003318	HupE / UreJ protein; Region: HupE_UreJ; cl01011
1080230003319	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1080230003320	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1080230003321	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1080230003322	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1080230003323	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1080230003324	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230003325	Mg2+ binding site [ion binding]; other site
1080230003326	G-X-G motif; other site
1080230003327	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1080230003328	anchoring element; other site
1080230003329	dimer interface [polypeptide binding]; other site
1080230003330	ATP binding site [chemical binding]; other site
1080230003331	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1080230003332	protein-splicing catalytic site; other site
1080230003333	thioester formation/cholesterol transfer; other site
1080230003334	Intein/homing endonuclease [DNA replication, recombination, and repair]; Region: COG1372
1080230003335	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942
1080230003336	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1080230003337	active site
1080230003338	putative metal-binding site [ion binding]; other site
1080230003339	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1080230003340	Protein of unknown function (DUF3571); Region: DUF3571; pfam12095
1080230003341	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
1080230003342	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1080230003343	FAD binding site [chemical binding]; other site
1080230003344	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
1080230003345	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230003346	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1080230003347	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1080230003348	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1080230003349	catalytic residue [active]
1080230003350	Protein of unknown function (DUF1092); Region: DUF1092; pfam06485
1080230003351	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230003352	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230003353	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230003354	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230003355	pteridine reductase; Provisional; Region: PRK09135
1080230003356	pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357
1080230003357	NADP binding site [chemical binding]; other site
1080230003358	substrate binding pocket [chemical binding]; other site
1080230003359	active site
1080230003360	Domain of unknown function (DUF427); Region: DUF427; cl00998
1080230003361	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1080230003362	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230003363	active site
1080230003364	phosphorylation site [posttranslational modification]
1080230003365	intermolecular recognition site; other site
1080230003366	dimerization interface [polypeptide binding]; other site
1080230003367	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230003368	DNA binding residues [nucleotide binding]
1080230003369	dimerization interface [polypeptide binding]; other site
1080230003370	Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447
1080230003371	MASE1; Region: MASE1; pfam05231
1080230003372	GAF domain; Region: GAF_2; pfam13185
1080230003373	GAF domain; Region: GAF; cl15785
1080230003374	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1080230003375	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230003376	ATP binding site [chemical binding]; other site
1080230003377	Mg2+ binding site [ion binding]; other site
1080230003378	G-X-G motif; other site
1080230003379	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1080230003380	short chain dehydrogenase; Provisional; Region: PRK06924
1080230003381	NADP binding site [chemical binding]; other site
1080230003382	homodimer interface [polypeptide binding]; other site
1080230003383	active site
1080230003384	signal peptide peptidase SppA, 67K type; Region: SppA_67K; TIGR00705
1080230003385	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
1080230003386	tandem repeat interface [polypeptide binding]; other site
1080230003387	oligomer interface [polypeptide binding]; other site
1080230003388	active site residues [active]
1080230003389	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1080230003390	tandem repeat interface [polypeptide binding]; other site
1080230003391	oligomer interface [polypeptide binding]; other site
1080230003392	active site residues [active]
1080230003393	Protein of function (DUF2518); Region: DUF2518; pfam10726
1080230003394	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230003395	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1080230003396	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1080230003397	tRNA; other site
1080230003398	putative tRNA binding site [nucleotide binding]; other site
1080230003399	putative NADP binding site [chemical binding]; other site
1080230003400	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1080230003401	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1080230003402	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
1080230003403	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
1080230003404	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1080230003405	Uncharacterized conserved protein [Function unknown]; Region: COG2006
1080230003406	Domain of unknown function (DUF362); Region: DUF362; pfam04015
1080230003407	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230003408	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230003409	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230003410	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230003411	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1080230003412	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230003413	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
1080230003414	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230003415	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
1080230003416	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
1080230003417	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230003418	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230003419	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1080230003420	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1080230003421	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1080230003422	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230003423	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230003424	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230003425	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230003426	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230003427	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230003428	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230003429	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1080230003430	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
1080230003431	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230003432	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1080230003433	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230003434	DNA binding residues [nucleotide binding]
1080230003435	threonine synthase; Validated; Region: PRK07591
1080230003436	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1080230003437	homodimer interface [polypeptide binding]; other site
1080230003438	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230003439	catalytic residue [active]
1080230003440	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230003441	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230003442	PAS fold; Region: PAS_3; pfam08447
1080230003443	putative active site [active]
1080230003444	heme pocket [chemical binding]; other site
1080230003445	PAS domain S-box; Region: sensory_box; TIGR00229
1080230003446	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230003447	putative active site [active]
1080230003448	heme pocket [chemical binding]; other site
1080230003449	PAS fold; Region: PAS_3; pfam08447
1080230003450	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230003451	putative active site [active]
1080230003452	heme pocket [chemical binding]; other site
1080230003453	PAS domain S-box; Region: sensory_box; TIGR00229
1080230003454	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230003455	putative active site [active]
1080230003456	heme pocket [chemical binding]; other site
1080230003457	GAF domain; Region: GAF; cl15785
1080230003458	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230003459	metal binding site [ion binding]; metal-binding site
1080230003460	active site
1080230003461	I-site; other site
1080230003462	RIP metalloprotease RseP; Region: TIGR00054
1080230003463	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1080230003464	active site
1080230003465	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1080230003466	protein binding site [polypeptide binding]; other site
1080230003467	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1080230003468	putative substrate binding region [chemical binding]; other site
1080230003469	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1080230003470	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1080230003471	minor groove reading motif; other site
1080230003472	helix-hairpin-helix signature motif; other site
1080230003473	substrate binding pocket [chemical binding]; other site
1080230003474	active site
1080230003475	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
1080230003476	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1080230003477	nucleoside/Zn binding site; other site
1080230003478	dimer interface [polypeptide binding]; other site
1080230003479	catalytic motif [active]
1080230003480	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230003481	cryptochrome, DASH family; Region: crypto_DASH; TIGR02765
1080230003482	DNA photolyase; Region: DNA_photolyase; pfam00875
1080230003483	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
1080230003484	TPR repeat; Region: TPR_11; pfam13414
1080230003485	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230003486	binding surface
1080230003487	TPR motif; other site
1080230003488	TPR repeat; Region: TPR_11; pfam13414
1080230003489	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
1080230003490	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
1080230003491	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; cl01359
1080230003492	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1080230003493	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
1080230003494	Walker A/P-loop; other site
1080230003495	ATP binding site [chemical binding]; other site
1080230003496	Q-loop/lid; other site
1080230003497	ABC transporter signature motif; other site
1080230003498	Walker B; other site
1080230003499	D-loop; other site
1080230003500	H-loop/switch region; other site
1080230003501	SOS regulatory protein LexA; Region: lexA; TIGR00498
1080230003502	Helix-turn-helix domains; Region: HTH; cl00088
1080230003503	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
1080230003504	succinate dehydrogenase iron-sulfur subunit; Provisional; Region: PRK12577
1080230003505	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
1080230003506	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1080230003507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230003508	active site
1080230003509	phosphorylation site [posttranslational modification]
1080230003510	intermolecular recognition site; other site
1080230003511	dimerization interface [polypeptide binding]; other site
1080230003512	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1080230003513	Zn2+ binding site [ion binding]; other site
1080230003514	Mg2+ binding site [ion binding]; other site
1080230003515	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1080230003516	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
1080230003517	Walker A/P-loop; other site
1080230003518	ATP binding site [chemical binding]; other site
1080230003519	Q-loop/lid; other site
1080230003520	ABC transporter signature motif; other site
1080230003521	Walker B; other site
1080230003522	D-loop; other site
1080230003523	H-loop/switch region; other site
1080230003524	UbiA prenyltransferase family; Region: UbiA; cl00337
1080230003525	Tocopherol cyclase; Region: Tocopherol_cycl; cl14571
1080230003526	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1080230003527	catalytic triad [active]
1080230003528	dimer interface [polypeptide binding]; other site
1080230003529	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1080230003530	metal binding site 2 [ion binding]; metal-binding site
1080230003531	putative DNA binding helix; other site
1080230003532	metal binding site 1 [ion binding]; metal-binding site
1080230003533	dimer interface [polypeptide binding]; other site
1080230003534	structural Zn2+ binding site [ion binding]; other site
1080230003535	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
1080230003536	Psb28 protein; Region: Psb28; cl04326
1080230003537	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
1080230003538	peptide binding site [polypeptide binding]; other site
1080230003539	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1080230003540	dimer interface [polypeptide binding]; other site
1080230003541	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1080230003542	catalytic triad [active]
1080230003543	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1080230003544	AMIN domain; Region: AMIN; pfam11741
1080230003545	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1080230003546	active site
1080230003547	metal binding site [ion binding]; metal-binding site
1080230003548	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1080230003549	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1080230003550	Rieske non-heme iron oxygenase (RO) family, Pheophorbide a oxygenase (PaO) subfamily, N-terminal Rieske domain of the oxygenase alpha subunit; composed of the oxygenase alpha subunits of a small subfamily of enzymes found in plants as well as oxygenic...; Region: Rieske_RO_Alpha_PaO; cd03480
1080230003551	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1080230003552	hydrophobic ligand binding site; other site
1080230003553	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1080230003554	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1080230003555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230003556	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1080230003557	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1080230003558	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230003559	Coenzyme A binding pocket [chemical binding]; other site
1080230003560	deoxyribodipyrimidine photo-lyase, 8-HDF type; Region: photolyase_8HDF; TIGR03556
1080230003561	DNA photolyase; Region: DNA_photolyase; pfam00875
1080230003562	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
1080230003563	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
1080230003564	dimer interface [polypeptide binding]; other site
1080230003565	RNA polymerase sigma factor; Provisional; Region: PRK12518
1080230003566	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230003567	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230003568	DNA binding residues [nucleotide binding]
1080230003569	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1080230003570	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
1080230003571	Cl- selectivity filter; other site
1080230003572	Cl- binding residues [ion binding]; other site
1080230003573	pore gating glutamate residue; other site
1080230003574	dimer interface [polypeptide binding]; other site
1080230003575	H+/Cl- coupling transport residue; other site
1080230003576	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230003577	CpeS-like protein; Region: CpeS; pfam09367
1080230003578	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230003579	Helix-turn-helix domains; Region: HTH; cl00088
1080230003580	Integrase core domain; Region: rve; cl01316
1080230003581	Photosystem II protein; Region: PSII; cl08223
1080230003582	photosystem II 44 kDa subunit reaction center protein (also called P6 protein, CP43), bacterial and chloroplast; Region: psbC; TIGR01153
1080230003583	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
1080230003584	D1 interface; other site
1080230003585	chlorophyll binding site; other site
1080230003586	pheophytin binding site; other site
1080230003587	beta carotene binding site; other site
1080230003588	cytochrome b559 beta interface; other site
1080230003589	quinone binding site; other site
1080230003590	cytochrome b559 alpha interface; other site
1080230003591	protein J interface; other site
1080230003592	protein H interface; other site
1080230003593	protein X interface; other site
1080230003594	core light harvesting protein interface; other site
1080230003595	protein L interface; other site
1080230003596	CP43 interface; other site
1080230003597	protein T interface; other site
1080230003598	Fe binding site [ion binding]; other site
1080230003599	protein M interface; other site
1080230003600	Mn-stabilizing polypeptide interface; other site
1080230003601	bromide binding site; other site
1080230003602	cytochrome c-550 interface; other site
1080230003603	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1080230003604	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1080230003605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230003606	Walker A motif; other site
1080230003607	ATP binding site [chemical binding]; other site
1080230003608	Walker B motif; other site
1080230003609	arginine finger; other site
1080230003610	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1080230003611	DnaA box-binding interface [nucleotide binding]; other site
1080230003612	Domain of unknown function (DUF202); Region: DUF202; cl09954
1080230003613	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1080230003614	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230003615	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230003616	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
1080230003617	Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only]; Region: COG2605
1080230003618	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1080230003619	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
1080230003620	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
1080230003621	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1080230003622	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420
1080230003623	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1080230003624	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1080230003625	active site
1080230003626	homodimer interface [polypeptide binding]; other site
1080230003627	catalytic site [active]
1080230003628	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1080230003629	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230003630	Walker A/P-loop; other site
1080230003631	ATP binding site [chemical binding]; other site
1080230003632	Q-loop/lid; other site
1080230003633	ABC transporter signature motif; other site
1080230003634	Walker B; other site
1080230003635	D-loop; other site
1080230003636	H-loop/switch region; other site
1080230003637	ABC transporter; Region: ABC_tran_2; pfam12848
1080230003638	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
1080230003639	Uncharacterized conserved protein [Function unknown]; Region: COG4301
1080230003640	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230003641	Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017
1080230003642	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
1080230003643	active site
1080230003644	dimer interface [polypeptide binding]; other site
1080230003645	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230003646	binding surface
1080230003647	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1080230003648	TPR motif; other site
1080230003649	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230003650	TPR repeat; Region: TPR_11; pfam13414
1080230003651	binding surface
1080230003652	TPR motif; other site
1080230003653	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230003654	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1080230003655	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230003656	G1 box; other site
1080230003657	GTP/Mg2+ binding site [chemical binding]; other site
1080230003658	G2 box; other site
1080230003659	Switch I region; other site
1080230003660	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230003661	G3 box; other site
1080230003662	Switch II region; other site
1080230003663	G4 box; other site
1080230003664	KGK domain; Region: KGK; pfam08872
1080230003665	KGK domain; Region: KGK; pfam08872
1080230003666	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1080230003667	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1080230003668	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1080230003669	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1080230003670	MutS domain I; Region: MutS_I; pfam01624
1080230003671	MutS domain II; Region: MutS_II; pfam05188
1080230003672	MutS family domain IV; Region: MutS_IV; pfam05190
1080230003673	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
1080230003674	Walker A/P-loop; other site
1080230003675	ATP binding site [chemical binding]; other site
1080230003676	Q-loop/lid; other site
1080230003677	ABC transporter signature motif; other site
1080230003678	Walker B; other site
1080230003679	D-loop; other site
1080230003680	H-loop/switch region; other site
1080230003681	Archaeal ATPase; Region: Arch_ATPase; pfam01637
1080230003682	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230003683	EamA-like transporter family; Region: EamA; cl01037
1080230003684	Cupin domain; Region: Cupin_2; cl09118
1080230003685	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
1080230003686	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230003687	catalytic loop [active]
1080230003688	iron binding site [ion binding]; other site
1080230003689	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1080230003690	cyclase homology domain; Region: CHD; cd07302
1080230003691	nucleotidyl binding site; other site
1080230003692	metal binding site [ion binding]; metal-binding site
1080230003693	dimer interface [polypeptide binding]; other site
1080230003694	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1080230003695	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1080230003696	putative catalytic residues [active]
1080230003697	LrgB-like family; Region: LrgB; cl00596
1080230003698	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1080230003699	Helix-turn-helix domains; Region: HTH; cl00088
1080230003700	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1080230003701	putative effector binding pocket; other site
1080230003702	dimerization interface [polypeptide binding]; other site
1080230003703	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230003704	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230003705	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1080230003706	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
1080230003707	Helix-turn-helix domains; Region: HTH; cl00088
1080230003708	Protein of unknown function (DUF2973); Region: DUF2973; pfam11189
1080230003709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230003710	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1080230003711	putative substrate translocation pore; other site
1080230003712	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230003713	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1080230003714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230003715	dimer interface [polypeptide binding]; other site
1080230003716	conserved gate region; other site
1080230003717	putative PBP binding loops; other site
1080230003718	ABC-ATPase subunit interface; other site
1080230003719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230003720	dimer interface [polypeptide binding]; other site
1080230003721	conserved gate region; other site
1080230003722	putative PBP binding loops; other site
1080230003723	ABC-ATPase subunit interface; other site
1080230003724	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1080230003725	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
1080230003726	Walker A/P-loop; other site
1080230003727	ATP binding site [chemical binding]; other site
1080230003728	Q-loop/lid; other site
1080230003729	ABC transporter signature motif; other site
1080230003730	Walker B; other site
1080230003731	D-loop; other site
1080230003732	H-loop/switch region; other site
1080230003733	cyclophilin_ABH_like: Cyclophilin  A, B and H-like cyclophilin-type peptidylprolyl cis- trans isomerase (PPIase) domain. This family represents the archetypal cystolic cyclophilin similar to human cyclophilins A, B and H. PPIase is an enzyme which...; Region: cyclophilin_ABH_like; cd01926
1080230003734	active site
1080230003735	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
1080230003736	aromatic arch; other site
1080230003737	DCoH dimer interaction site [polypeptide binding]; other site
1080230003738	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1080230003739	DCoH tetramer interaction site [polypeptide binding]; other site
1080230003740	substrate binding site [chemical binding]; other site
1080230003741	Domain of unknown function (DUF389); Region: DUF389; cl00781
1080230003742	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
1080230003743	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
1080230003744	phytoene desaturase; Region: phytoene_desat; TIGR02731
1080230003745	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230003746	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1080230003747	active site lid residues [active]
1080230003748	substrate binding pocket [chemical binding]; other site
1080230003749	catalytic residues [active]
1080230003750	substrate-Mg2+ binding site; other site
1080230003751	aspartate-rich region 1; other site
1080230003752	aspartate-rich region 2; other site
1080230003753	MAPEG family; Region: MAPEG; cl09190
1080230003754	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1080230003755	alpha-gamma subunit interface [polypeptide binding]; other site
1080230003756	beta-gamma subunit interface [polypeptide binding]; other site
1080230003757	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230003758	substrate binding pocket [chemical binding]; other site
1080230003759	Ion channel; Region: Ion_trans_2; cl11596
1080230003760	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230003761	membrane-bound complex binding site; other site
1080230003762	hinge residues; other site
1080230003763	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1080230003764	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230003765	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1080230003766	Protein of unknown function (DUF3122); Region: DUF3122; pfam11320
1080230003767	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1080230003768	active site residue [active]
1080230003769	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
1080230003770	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
1080230003771	Predicted transcriptional regulators [Transcription]; Region: COG1725
1080230003772	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1080230003773	DNA-binding site [nucleotide binding]; DNA binding site
1080230003774	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1080230003775	active site
1080230003776	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
1080230003777	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1080230003778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230003779	homodimer interface [polypeptide binding]; other site
1080230003780	catalytic residue [active]
1080230003781	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1080230003782	dimerization interface [polypeptide binding]; other site
1080230003783	putative DNA binding site [nucleotide binding]; other site
1080230003784	putative Zn2+ binding site [ion binding]; other site
1080230003785	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1080230003786	amphipathic channel; other site
1080230003787	Asn-Pro-Ala signature motifs; other site
1080230003788	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1080230003789	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1080230003790	active site
1080230003791	interdomain interaction site; other site
1080230003792	putative metal-binding site [ion binding]; other site
1080230003793	nucleotide binding site [chemical binding]; other site
1080230003794	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986
1080230003795	domain I; other site
1080230003796	phosphate binding site [ion binding]; other site
1080230003797	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1080230003798	domain II; other site
1080230003799	domain III; other site
1080230003800	nucleotide binding site [chemical binding]; other site
1080230003801	DNA binding groove [nucleotide binding]
1080230003802	catalytic site [active]
1080230003803	domain IV; other site
1080230003804	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1080230003805	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1080230003806	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1080230003807	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1080230003808	NIL domain; Region: NIL; cl09633
1080230003809	4Fe-4S binding domain; Region: Fer4; cl02805
1080230003810	hypothetical protein; Provisional; Region: PRK13795
1080230003811	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230003812	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230003813	putative active site [active]
1080230003814	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
1080230003815	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
1080230003816	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
1080230003817	Probable transposase; Region: OrfB_IS605; pfam01385
1080230003818	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
1080230003819	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1080230003820	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230003821	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230003822	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230003823	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
1080230003824	ribosomal protein L11 methyltransferase; Region: prmA; TIGR00406
1080230003825	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230003826	S-adenosylmethionine binding site [chemical binding]; other site
1080230003827	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1080230003828	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230003829	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1080230003830	putative L-serine binding site [chemical binding]; other site
1080230003831	Protein of unknown function (DUF3120); Region: DUF3120; pfam11318
1080230003832	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230003833	phosphopeptide binding site; other site
1080230003834	cyclase homology domain; Region: CHD; cd07302
1080230003835	nucleotidyl binding site; other site
1080230003836	metal binding site [ion binding]; metal-binding site
1080230003837	dimer interface [polypeptide binding]; other site
1080230003838	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1080230003839	catalytic residues [active]
1080230003840	dimer interface [polypeptide binding]; other site
1080230003841	putative acyltransferase; Provisional; Region: PRK05790
1080230003842	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1080230003843	dimer interface [polypeptide binding]; other site
1080230003844	active site
1080230003845	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1080230003846	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1080230003847	NAD(P) binding site [chemical binding]; other site
1080230003848	homotetramer interface [polypeptide binding]; other site
1080230003849	homodimer interface [polypeptide binding]; other site
1080230003850	active site
1080230003851	PUCC protein; Region: PUCC; pfam03209
1080230003852	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230003853	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230003854	active site
1080230003855	phosphorylation site [posttranslational modification]
1080230003856	intermolecular recognition site; other site
1080230003857	dimerization interface [polypeptide binding]; other site
1080230003858	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230003859	PAS fold; Region: PAS_4; pfam08448
1080230003860	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1080230003861	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
1080230003862	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230003863	dimer interface [polypeptide binding]; other site
1080230003864	phosphorylation site [posttranslational modification]
1080230003865	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230003866	ATP binding site [chemical binding]; other site
1080230003867	Mg2+ binding site [ion binding]; other site
1080230003868	G-X-G motif; other site
1080230003869	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230003870	active site
1080230003871	phosphorylation site [posttranslational modification]
1080230003872	intermolecular recognition site; other site
1080230003873	dimerization interface [polypeptide binding]; other site
1080230003874	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1080230003875	putative binding surface; other site
1080230003876	active site
1080230003877	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1080230003878	YcfA-like protein; Region: YcfA; cl00752
1080230003879	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230003880	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
1080230003881	proposed catalytic triad [active]
1080230003882	active site nucleophile [active]
1080230003883	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
1080230003884	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230003885	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1080230003886	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1080230003887	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1080230003888	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1080230003889	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1080230003890	C-terminal domain interface [polypeptide binding]; other site
1080230003891	GSH binding site (G-site) [chemical binding]; other site
1080230003892	dimer interface [polypeptide binding]; other site
1080230003893	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1080230003894	N-terminal domain interface [polypeptide binding]; other site
1080230003895	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1080230003896	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1080230003897	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1080230003898	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1080230003899	G1 box; other site
1080230003900	GTP/Mg2+ binding site [chemical binding]; other site
1080230003901	Switch I region; other site
1080230003902	G2 box; other site
1080230003903	Switch II region; other site
1080230003904	G3 box; other site
1080230003905	G4 box; other site
1080230003906	G5 box; other site
1080230003907	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1080230003908	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1080230003909	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
1080230003910	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230003911	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1080230003912	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230003913	motif II; other site
1080230003914	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1080230003915	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1080230003916	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1080230003917	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1080230003918	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1080230003919	putative di-iron ligands [ion binding]; other site
1080230003920	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230003921	Helix-turn-helix domains; Region: HTH; cl00088
1080230003922	Integrase core domain; Region: rve; cl01316
1080230003923	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230003924	putative active site [active]
1080230003925	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1080230003926	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
1080230003927	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1080230003928	TIGR00268 family protein; Region: TIGR00268
1080230003929	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1080230003930	Ligand Binding Site [chemical binding]; other site
1080230003931	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1080230003932	putative active site [active]
1080230003933	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1080230003934	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
1080230003935	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
1080230003936	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1080230003937	dimer interface [polypeptide binding]; other site
1080230003938	FMN binding site [chemical binding]; other site
1080230003939	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1080230003940	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1080230003941	dimer interface [polypeptide binding]; other site
1080230003942	anticodon binding site; other site
1080230003943	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
1080230003944	homodimer interface [polypeptide binding]; other site
1080230003945	motif 1; other site
1080230003946	active site
1080230003947	motif 2; other site
1080230003948	GAD domain; Region: GAD; pfam02938
1080230003949	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
1080230003950	motif 3; other site
1080230003951	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
1080230003952	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
1080230003953	active site
1080230003954	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230003955	dimer interface [polypeptide binding]; other site
1080230003956	conserved gate region; other site
1080230003957	putative PBP binding loops; other site
1080230003958	ABC-ATPase subunit interface; other site
1080230003959	Uncharacterized conserved protein [Function unknown]; Region: COG3268
1080230003960	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230003961	Protein of unknown function (DUF3153); Region: DUF3153; pfam11353
1080230003962	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
1080230003963	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1080230003964	ABC-ATPase subunit  interface; other site
1080230003965	dimer interface [polypeptide binding]; other site
1080230003966	putative PBP binding regions; other site
1080230003967	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1080230003968	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
1080230003969	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1080230003970	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1080230003971	metal binding site [ion binding]; metal-binding site
1080230003972	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230003973	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
1080230003974	tetramer interface [polypeptide binding]; other site
1080230003975	dimer interface [polypeptide binding]; other site
1080230003976	circadian clock protein KaiC; Reviewed; Region: PRK09302
1080230003977	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230003978	Walker A motif; other site
1080230003979	ATP binding site [chemical binding]; other site
1080230003980	Walker B motif; other site
1080230003981	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230003982	Walker A motif; other site
1080230003983	ATP binding site [chemical binding]; other site
1080230003984	Walker B motif; other site
1080230003985	Protein of unknown function (DUF4230); Region: DUF4230; pfam14014
1080230003986	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1080230003987	Helix-turn-helix domains; Region: HTH; cl00088
1080230003988	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1080230003989	putative dimerization interface [polypeptide binding]; other site
1080230003990	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1080230003991	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1080230003992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230003993	active site
1080230003994	phosphorylation site [posttranslational modification]
1080230003995	intermolecular recognition site; other site
1080230003996	dimerization interface [polypeptide binding]; other site
1080230003997	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230003998	DNA binding residues [nucleotide binding]
1080230003999	dimerization interface [polypeptide binding]; other site
1080230004000	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230004001	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1080230004002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004003	ATP binding site [chemical binding]; other site
1080230004004	Mg2+ binding site [ion binding]; other site
1080230004005	G-X-G motif; other site
1080230004006	Potassium-transporting ATPase A subunit; Region: KdpA; cl00903
1080230004007	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
1080230004008	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230004009	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230004010	K+-transporting ATPase, c chain; Region: KdpC; cl00944
1080230004011	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
1080230004012	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
1080230004013	Ligand Binding Site [chemical binding]; other site
1080230004014	Domain of Unknown Function (DUF748); Region: DUF748; pfam05359
1080230004015	AsmA-like C-terminal region; Region: AsmA_2; cl15864
1080230004016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1080230004017	Family of unknown function (DUF490); Region: DUF490; pfam04357
1080230004018	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1080230004019	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230004020	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1080230004021	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1080230004022	iron-sulfur cluster [ion binding]; other site
1080230004023	[2Fe-2S] cluster binding site [ion binding]; other site
1080230004024	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1080230004025	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230004026	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1080230004027	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1080230004028	homodimer interface [polypeptide binding]; other site
1080230004029	Walker A motif; other site
1080230004030	ATP binding site [chemical binding]; other site
1080230004031	hydroxycobalamin binding site [chemical binding]; other site
1080230004032	Walker B motif; other site
1080230004033	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
1080230004034	Stage II sporulation protein; Region: SpoIID; pfam08486
1080230004035	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
1080230004036	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
1080230004037	Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429
1080230004038	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230004039	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230004040	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230004041	phosphopantothenoylcysteine decarboxylase / phosphopantothenate--cysteine ligase; Region: coaBC_dfp; TIGR00521
1080230004042	Flavoprotein; Region: Flavoprotein; cl08021
1080230004043	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
1080230004044	Protein of unknown function (DUF2555); Region: DUF2555; pfam10742
1080230004045	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230004046	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1080230004047	Photosystem II protein; Region: PSII; cl08223
1080230004048	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1080230004049	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1080230004050	GTP/Mg2+ binding site [chemical binding]; other site
1080230004051	G4 box; other site
1080230004052	G5 box; other site
1080230004053	G1 box; other site
1080230004054	Switch I region; other site
1080230004055	G2 box; other site
1080230004056	G3 box; other site
1080230004057	Switch II region; other site
1080230004058	GTP-binding protein YchF; Reviewed; Region: PRK09601
1080230004059	YchF GTPase; Region: YchF; cd01900
1080230004060	G1 box; other site
1080230004061	GTP/Mg2+ binding site [chemical binding]; other site
1080230004062	Switch I region; other site
1080230004063	G2 box; other site
1080230004064	Switch II region; other site
1080230004065	G3 box; other site
1080230004066	G4 box; other site
1080230004067	G5 box; other site
1080230004068	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1080230004069	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1080230004070	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1080230004071	NAD binding site [chemical binding]; other site
1080230004072	homodimer interface [polypeptide binding]; other site
1080230004073	active site
1080230004074	substrate binding site [chemical binding]; other site
1080230004075	Protein of unknown function (DUF2605); Region: DUF2605; pfam10792
1080230004076	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
1080230004077	Phycobilisome degradation protein nblA; Region: NblA; pfam04485
1080230004078	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1080230004079	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1080230004080	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1080230004081	Double zinc ribbon; Region: DZR; pfam12773
1080230004082	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1080230004083	Predicted periplasmic ligand-binding sensor domain [Signal transduction mechanisms]; Region: COG3292
1080230004084	Two component regulator propeller; Region: Reg_prop; pfam07494
1080230004085	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1080230004086	ABC Carbohydrate and Solute Transporters-like subgroup.  This family is comprised of proteins involved in the transport of apparently unrelated solutes and proteins specific for di- and oligosaccharides and polyols.  ABC transporters are a large family...; Region: ABC_Carb_Solutes_like; cd03259
1080230004087	Walker A/P-loop; other site
1080230004088	ATP binding site [chemical binding]; other site
1080230004089	Q-loop/lid; other site
1080230004090	ABC transporter signature motif; other site
1080230004091	Walker B; other site
1080230004092	D-loop; other site
1080230004093	H-loop/switch region; other site
1080230004094	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1080230004095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1080230004096	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230004097	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1080230004098	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364
1080230004099	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_8; cd06905
1080230004100	putative active site [active]
1080230004101	Zn binding site [ion binding]; other site
1080230004102	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
1080230004103	Glutaminase; Region: Glutaminase; cl00907
1080230004104	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1080230004105	active site
1080230004106	arogenate dehydrogenase; Reviewed; Region: PRK07417
1080230004107	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230004108	cytochrome c oxidase subunit I; Validated; Region: COX1; MTH00007
1080230004109	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1080230004110	D-pathway; other site
1080230004111	Low-spin heme binding site [chemical binding]; other site
1080230004112	Putative water exit pathway; other site
1080230004113	Binuclear center (active site) [active]
1080230004114	K-pathway; other site
1080230004115	Putative proton exit pathway; other site
1080230004116	Heme-copper oxidase subunit III.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386
1080230004117	Subunit I/III interface [polypeptide binding]; other site
1080230004118	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230004119	putative active site [active]
1080230004120	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1080230004121	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1080230004122	dimerization interface [polypeptide binding]; other site
1080230004123	domain crossover interface; other site
1080230004124	redox-dependent activation switch; other site
1080230004125	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1080230004126	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1080230004127	dimer interface [polypeptide binding]; other site
1080230004128	active site
1080230004129	heme binding site [chemical binding]; other site
1080230004130	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1080230004131	ResB-like family; Region: ResB; pfam05140
1080230004132	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1080230004133	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK07418
1080230004134	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1080230004135	PYR/PP interface [polypeptide binding]; other site
1080230004136	dimer interface [polypeptide binding]; other site
1080230004137	TPP binding site [chemical binding]; other site
1080230004138	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
1080230004139	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1080230004140	TPP-binding site [chemical binding]; other site
1080230004141	dimer interface [polypeptide binding]; other site
1080230004142	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1080230004143	squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507
1080230004144	Squalene cyclase (SQCY) domain subgroup 1; found in class II terpene cyclases that have an alpha 6 - alpha 6 barrel fold. Squalene cyclase (SQCY)  and 2,3-oxidosqualene cyclase (OSQCY) are integral membrane proteins that catalyze a cationic cyclization...; Region: SQCY_1; cd02892
1080230004145	Active site cavity [active]
1080230004146	catalytic acid [active]
1080230004147	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230004148	Integrase core domain; Region: rve; cl01316
1080230004149	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230004150	Helix-turn-helix domains; Region: HTH; cl00088
1080230004151	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230004152	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230004153	putative active site [active]
1080230004154	acetolactate synthase; Reviewed; Region: PRK08322
1080230004155	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1080230004156	PYR/PP interface [polypeptide binding]; other site
1080230004157	dimer interface [polypeptide binding]; other site
1080230004158	TPP binding site [chemical binding]; other site
1080230004159	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
1080230004160	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
1080230004161	TPP-binding site [chemical binding]; other site
1080230004162	dimer interface [polypeptide binding]; other site
1080230004163	TRX-like protein A (TxlA) family; TxlA was originally isolated from the cyanobacterium Synechococcus. It is found only in oxygenic photosynthetic organisms. TRX is a small enzyme that participate in redox reactions, via the reversible oxidation of an...; Region: TxlA; cd02950
1080230004164	catalytic residues [active]
1080230004165	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1080230004166	putative active site [active]
1080230004167	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
1080230004168	Helix-turn-helix domains; Region: HTH; cl00088
1080230004169	IS1 transposase; Region: DDE_Tnp_IS1; cl00721
1080230004170	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1080230004171	apolar tunnel; other site
1080230004172	heme binding site [chemical binding]; other site
1080230004173	dimerization interface [polypeptide binding]; other site
1080230004174	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1080230004175	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1080230004176	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1080230004177	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1080230004178	PAS domain S-box; Region: sensory_box; TIGR00229
1080230004179	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230004180	putative active site [active]
1080230004181	heme pocket [chemical binding]; other site
1080230004182	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1080230004183	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004184	dimer interface [polypeptide binding]; other site
1080230004185	phosphorylation site [posttranslational modification]
1080230004186	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004187	ATP binding site [chemical binding]; other site
1080230004188	Mg2+ binding site [ion binding]; other site
1080230004189	G-X-G motif; other site
1080230004190	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004191	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004192	active site
1080230004193	phosphorylation site [posttranslational modification]
1080230004194	intermolecular recognition site; other site
1080230004195	dimerization interface [polypeptide binding]; other site
1080230004196	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004197	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004198	active site
1080230004199	phosphorylation site [posttranslational modification]
1080230004200	intermolecular recognition site; other site
1080230004201	dimerization interface [polypeptide binding]; other site
1080230004202	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1080230004203	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004205	active site
1080230004206	phosphorylation site [posttranslational modification]
1080230004207	intermolecular recognition site; other site
1080230004208	dimerization interface [polypeptide binding]; other site
1080230004209	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004210	dimer interface [polypeptide binding]; other site
1080230004211	phosphorylation site [posttranslational modification]
1080230004212	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004213	ATP binding site [chemical binding]; other site
1080230004214	Mg2+ binding site [ion binding]; other site
1080230004215	G-X-G motif; other site
1080230004216	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1080230004217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004218	active site
1080230004219	phosphorylation site [posttranslational modification]
1080230004220	intermolecular recognition site; other site
1080230004221	dimerization interface [polypeptide binding]; other site
1080230004222	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1080230004223	Zn2+ binding site [ion binding]; other site
1080230004224	Mg2+ binding site [ion binding]; other site
1080230004225	Cupin domain; Region: Cupin_2; cl09118
1080230004226	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1080230004227	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
1080230004228	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1080230004229	P loop; other site
1080230004230	GTP binding site [chemical binding]; other site
1080230004231	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1080230004232	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Region: LPLAT_MGAT-like; cd07987
1080230004233	putative acyl-acceptor binding pocket; other site
1080230004234	GAF domain; Region: GAF_2; pfam13185
1080230004235	GAF domain; Region: GAF; cl15785
1080230004236	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230004237	PAS fold; Region: PAS_3; pfam08447
1080230004238	putative active site [active]
1080230004239	heme pocket [chemical binding]; other site
1080230004240	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004241	dimer interface [polypeptide binding]; other site
1080230004242	phosphorylation site [posttranslational modification]
1080230004243	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004244	ATP binding site [chemical binding]; other site
1080230004245	Mg2+ binding site [ion binding]; other site
1080230004246	G-X-G motif; other site
1080230004247	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004249	active site
1080230004250	phosphorylation site [posttranslational modification]
1080230004251	intermolecular recognition site; other site
1080230004252	dimerization interface [polypeptide binding]; other site
1080230004253	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1080230004254	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
1080230004255	ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; COG3225
1080230004256	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
1080230004257	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1080230004258	active site
1080230004259	Predicted endonuclease distantly related to archaeal Holliday junction resolvase and Mrr-like restriction enzymes [Defense mechanisms]; Region: COG1787
1080230004260	Restriction endonuclease; Region: Mrr_cat; cl00516
1080230004261	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1080230004262	Helix-turn-helix domains; Region: HTH; cl00088
1080230004263	bile acid transporter; Region: bass; TIGR00841
1080230004264	Membrane transport protein; Region: Mem_trans; cl09117
1080230004265	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
1080230004266	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1080230004267	active site
1080230004268	catalytic tetrad [active]
1080230004269	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
1080230004270	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1080230004271	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1080230004272	protein binding site [polypeptide binding]; other site
1080230004273	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1080230004274	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
1080230004275	dimer interface [polypeptide binding]; other site
1080230004276	motif 1; other site
1080230004277	active site
1080230004278	motif 2; other site
1080230004279	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1080230004280	putative deacylase active site [active]
1080230004281	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
1080230004282	active site
1080230004283	motif 3; other site
1080230004284	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1080230004285	anticodon binding site; other site
1080230004286	Late competence development protein ComFB; Region: ComFB; pfam10719
1080230004287	Uncharacterized protein conserved in bacteria with the myosin-like domain [Function unknown]; Region: COG4372
1080230004288	Protein of unknown function (DUF3084); Region: DUF3084; pfam11283
1080230004289	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230004290	global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697
1080230004291	ligand binding site [chemical binding]; other site
1080230004292	flexible hinge region; other site
1080230004293	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1080230004294	putative switch regulator; other site
1080230004295	non-specific DNA interactions [nucleotide binding]; other site
1080230004296	DNA binding site [nucleotide binding]
1080230004297	sequence specific DNA binding site [nucleotide binding]; other site
1080230004298	putative cAMP binding site [chemical binding]; other site
1080230004299	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
1080230004300	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
1080230004301	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1080230004302	hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470
1080230004303	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230004304	FeS/SAM binding site; other site
1080230004305	Domain of unknown function (DUF3463); Region: DUF3463; pfam11946
1080230004306	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230004307	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1080230004308	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1080230004309	Cation transport protein; Region: TrkH; cl10514
1080230004310	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
1080230004311	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1080230004312	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1080230004313	dimer interface [polypeptide binding]; other site
1080230004314	active site
1080230004315	CoA binding pocket [chemical binding]; other site
1080230004316	PsbP; Region: PsbP; cl03356
1080230004317	Domain of unknown function (DUF897); Region: DUF897; cl01312
1080230004318	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
1080230004319	Thylakoid formation protein; Region: ThylakoidFormat; cl12138
1080230004320	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1080230004321	O-Antigen ligase; Region: Wzy_C; cl04850
1080230004322	Protein of unknown function (DUF3288); Region: DUF3288; pfam11691
1080230004323	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1080230004324	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1080230004325	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1080230004326	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1080230004327	tartrate dehydrogenase; Provisional; Region: PRK08194
1080230004328	UbiA prenyltransferase family; Region: UbiA; cl00337
1080230004329	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230004330	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230004331	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230004332	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230004333	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230004334	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230004335	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230004336	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230004337	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1080230004338	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1080230004339	active site
1080230004340	catalytic tetrad [active]
1080230004341	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1080230004342	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1080230004343	HflX GTPase family; Region: HflX; cd01878
1080230004344	G1 box; other site
1080230004345	GTP/Mg2+ binding site [chemical binding]; other site
1080230004346	Switch I region; other site
1080230004347	G2 box; other site
1080230004348	G3 box; other site
1080230004349	Switch II region; other site
1080230004350	G4 box; other site
1080230004351	G5 box; other site
1080230004352	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230004353	HTH-like domain; Region: HTH_21; pfam13276
1080230004354	Integrase core domain; Region: rve; cl01316
1080230004355	Integrase core domain; Region: rve_3; cl15866
1080230004356	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230004357	Helix-turn-helix domains; Region: HTH; cl00088
1080230004358	Protein of unknown function DUF86; Region: DUF86; cl01031
1080230004359	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1080230004360	active site
1080230004361	NTP binding site [chemical binding]; other site
1080230004362	metal binding triad [ion binding]; metal-binding site
1080230004363	antibiotic binding site [chemical binding]; other site
1080230004364	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1080230004365	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1080230004366	interface (dimer of trimers) [polypeptide binding]; other site
1080230004367	Substrate-binding/catalytic site; other site
1080230004368	Zn-binding sites [ion binding]; other site
1080230004369	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1080230004370	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1080230004371	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1080230004372	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
1080230004373	Walker A/P-loop; other site
1080230004374	ATP binding site [chemical binding]; other site
1080230004375	Q-loop/lid; other site
1080230004376	ABC transporter signature motif; other site
1080230004377	Walker B; other site
1080230004378	D-loop; other site
1080230004379	H-loop/switch region; other site
1080230004380	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1080230004381	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230004382	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230004383	Helix-turn-helix domains; Region: HTH; cl00088
1080230004384	Integrase core domain; Region: rve; cl01316
1080230004385	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1080230004386	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
1080230004387	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
1080230004388	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230004389	Helix-turn-helix domains; Region: HTH; cl00088
1080230004390	Integrase core domain; Region: rve; cl01316
1080230004391	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1080230004392	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1080230004393	inhibitor-cofactor binding pocket; inhibition site
1080230004394	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230004395	catalytic residue [active]
1080230004396	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1080230004397	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230004398	active site
1080230004399	Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135
1080230004400	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230004401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230004402	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1080230004403	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230004404	active site
1080230004405	Putative cyclase; Region: Cyclase; cl00814
1080230004406	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
1080230004407	ligand binding site; other site
1080230004408	tetramer interface; other site
1080230004409	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1080230004410	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230004411	short chain dehydrogenase; Provisional; Region: PRK06138
1080230004412	classical (c) SDRs; Region: SDR_c; cd05233
1080230004413	NAD(P) binding site [chemical binding]; other site
1080230004414	active site
1080230004415	Thiamin pyrophosphokinase, catalytic domain; Region: TPK_catalytic; cl09135
1080230004416	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1080230004417	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230004418	active site
1080230004419	Restriction endonuclease; Region: Mrr_cat; cl00516
1080230004420	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230004421	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1080230004422	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230004423	active site
1080230004424	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1080230004425	dimer interface [polypeptide binding]; other site
1080230004426	active site
1080230004427	Schiff base residues; other site
1080230004428	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1080230004429	active site
1080230004430	dimer interface [polypeptide binding]; other site
1080230004431	metal binding site [ion binding]; metal-binding site
1080230004432	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1080230004433	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
1080230004434	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
1080230004435	HemK family putative methylases; Region: hemK_fam; TIGR00536
1080230004436	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230004437	S-adenosylmethionine binding site [chemical binding]; other site
1080230004438	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1080230004439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004440	active site
1080230004441	phosphorylation site [posttranslational modification]
1080230004442	intermolecular recognition site; other site
1080230004443	dimerization interface [polypeptide binding]; other site
1080230004444	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004445	dimer interface [polypeptide binding]; other site
1080230004446	phosphorylation site [posttranslational modification]
1080230004447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004448	ATP binding site [chemical binding]; other site
1080230004449	Mg2+ binding site [ion binding]; other site
1080230004450	G-X-G motif; other site
1080230004451	(p)ppGpp synthetase, RelA/SpoT family; Region: spoT_relA; TIGR00691
1080230004452	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1080230004453	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1080230004454	synthetase active site [active]
1080230004455	NTP binding site [chemical binding]; other site
1080230004456	metal binding site [ion binding]; metal-binding site
1080230004457	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1080230004458	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1080230004459	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1080230004460	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230004461	oligomerization interface [polypeptide binding]; other site
1080230004462	active site
1080230004463	NAD+ binding site [chemical binding]; other site
1080230004464	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230004465	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1080230004466	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1080230004467	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
1080230004468	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230004469	putative active site [active]
1080230004470	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1080230004471	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004472	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004473	active site
1080230004474	phosphorylation site [posttranslational modification]
1080230004475	intermolecular recognition site; other site
1080230004476	dimerization interface [polypeptide binding]; other site
1080230004477	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1080230004478	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004479	ATP binding site [chemical binding]; other site
1080230004480	Mg2+ binding site [ion binding]; other site
1080230004481	G-X-G motif; other site
1080230004482	GAF domain; Region: GAF_2; pfam13185
1080230004483	GAF domain; Region: GAF; cl15785
1080230004484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004485	dimer interface [polypeptide binding]; other site
1080230004486	phosphorylation site [posttranslational modification]
1080230004487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004488	ATP binding site [chemical binding]; other site
1080230004489	Mg2+ binding site [ion binding]; other site
1080230004490	G-X-G motif; other site
1080230004491	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004493	active site
1080230004494	phosphorylation site [posttranslational modification]
1080230004495	intermolecular recognition site; other site
1080230004496	dimerization interface [polypeptide binding]; other site
1080230004497	ATP synthase CF1 beta subunit; Region: atpB; CHL00060
1080230004498	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
1080230004499	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1080230004500	alpha subunit interaction interface [polypeptide binding]; other site
1080230004501	Walker A motif; other site
1080230004502	ATP binding site [chemical binding]; other site
1080230004503	Walker B motif; other site
1080230004504	inhibitor binding site; inhibition site
1080230004505	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1080230004506	ATP synthase CF1 epsilon subunit; Region: atpE; CHL00063
1080230004507	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
1080230004508	ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401
1080230004509	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1080230004510	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1080230004511	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05952
1080230004512	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1080230004513	dimer interface [polypeptide binding]; other site
1080230004514	active site
1080230004515	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
1080230004516	PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873
1080230004517	putative active site [active]
1080230004518	homotetrameric interface [polypeptide binding]; other site
1080230004519	metal binding site [ion binding]; metal-binding site
1080230004520	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
1080230004521	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
1080230004522	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230004523	catalytic loop [active]
1080230004524	iron binding site [ion binding]; other site
1080230004525	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
1080230004526	4Fe-4S binding domain; Region: Fer4; cl02805
1080230004527	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230004528	putative active site [active]
1080230004529	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1080230004530	dimer interface [polypeptide binding]; other site
1080230004531	[2Fe-2S] cluster binding site [ion binding]; other site
1080230004532	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1080230004533	SLBB domain; Region: SLBB; pfam10531
1080230004534	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
1080230004535	NADH:ubiquinone oxidoreductase 24 kD subunit [Energy production and conversion]; Region: NuoE; COG1905
1080230004536	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1080230004537	putative dimer interface [polypeptide binding]; other site
1080230004538	[2Fe-2S] cluster binding site [ion binding]; other site
1080230004539	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230004540	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1080230004541	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
1080230004542	active site
1080230004543	substrate binding site [chemical binding]; other site
1080230004544	metal binding site [ion binding]; metal-binding site
1080230004545	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1080230004546	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1080230004547	NAD(P) binding site [chemical binding]; other site
1080230004548	putative active site [active]
1080230004549	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1080230004550	active site
1080230004551	Fe-S cluster binding site [ion binding]; other site
1080230004552	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230004553	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230004554	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1080230004555	FAD binding domain; Region: FAD_binding_4; pfam01565
1080230004556	Photosystem I reaction centre subunit IX / PsaJ; Region: PSI_PsaJ; cl03320
1080230004557	Photosystem I reaction centre subunit III; Region: PSI_PsaF; cl03627
1080230004558	UGMP family protein; Validated; Region: PRK09604
1080230004559	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
1080230004560	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1080230004561	RimM N-terminal domain; Region: RimM; pfam01782
1080230004562	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
1080230004563	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1080230004564	UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230
1080230004565	NAD binding site [chemical binding]; other site
1080230004566	putative substrate binding site 2 [chemical binding]; other site
1080230004567	putative substrate binding site 1 [chemical binding]; other site
1080230004568	active site
1080230004569	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1080230004570	Predicted methyltransferases [General function prediction only]; Region: COG0313
1080230004571	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
1080230004572	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1080230004573	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230004574	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1080230004575	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230004576	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
1080230004577	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1080230004578	Protein of unknown function (DUF422); Region: DUF422; cl00991
1080230004579	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1080230004580	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
1080230004581	Type III pantothenate kinase; Region: Pan_kinase; cl09130
1080230004582	hopanoid biosynthesis associated glycosyl transferase protein HpnI; Region: HpnI; TIGR03472
1080230004583	Glucosylceramide synthase catalyzes the first glycosylation step of glycosphingolipid synthesis; Region: Glucosylceramide_synthase; cd02520
1080230004584	ligand binding site; other site
1080230004585	NADH dehydrogenase transmembrane subunit; Region: NdhL; pfam10716
1080230004586	Protein of unknown function (DUF3007); Region: DUF3007; pfam11460
1080230004587	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
1080230004588	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230004589	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1080230004590	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
1080230004591	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1080230004592	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1080230004593	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1080230004594	putative active site [active]
1080230004595	catalytic triad [active]
1080230004596	putative dimer interface [polypeptide binding]; other site
1080230004597	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1080230004598	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1080230004599	Bacterial sugar transferase; Region: Bac_transf; cl00939
1080230004600	Integrase core domain; Region: rve; cl01316
1080230004601	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230004602	Helix-turn-helix domains; Region: HTH; cl00088
1080230004603	Integrase core domain; Region: rve; cl01316
1080230004604	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1080230004605	MoaE interaction surface [polypeptide binding]; other site
1080230004606	MoeB interaction surface [polypeptide binding]; other site
1080230004607	thiocarboxylated glycine; other site
1080230004608	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1080230004609	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
1080230004610	substrate binding site [chemical binding]; other site
1080230004611	hexamer interface [polypeptide binding]; other site
1080230004612	metal binding site [ion binding]; metal-binding site
1080230004613	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1080230004614	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
1080230004615	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230004616	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1080230004617	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230004618	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1080230004619	photosystem I assembly protein Ycf3; Provisional; Region: PRK02603
1080230004620	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004621	binding surface
1080230004622	TPR motif; other site
1080230004623	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1080230004624	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1080230004625	G1 box; other site
1080230004626	GTP/Mg2+ binding site [chemical binding]; other site
1080230004627	Switch I region; other site
1080230004628	G2 box; other site
1080230004629	Switch II region; other site
1080230004630	G3 box; other site
1080230004631	G4 box; other site
1080230004632	G5 box; other site
1080230004633	Domain of unknown function (DUF697); Region: DUF697; cl12064
1080230004634	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230004635	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230004636	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1080230004637	Cation efflux family; Region: Cation_efflux; cl00316
1080230004638	NADH-quinone oxidoreductase cyanobacterial subunit N; Region: NdhN; pfam11909
1080230004639	elongation factor Ts; Reviewed; Region: tsf; PRK12332
1080230004640	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
1080230004641	Elongation factor TS; Region: EF_TS; pfam00889
1080230004642	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1080230004643	rRNA interaction site [nucleotide binding]; other site
1080230004644	S8 interaction site; other site
1080230004645	putative laminin-1 binding site; other site
1080230004646	calcium/proton exchanger (cax); Region: cax; TIGR00378
1080230004647	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1080230004648	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1080230004649	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1080230004650	trimer interface [polypeptide binding]; other site
1080230004651	active site
1080230004652	Integrase core domain; Region: rve; cl01316
1080230004653	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230004654	Helix-turn-helix domains; Region: HTH; cl00088
1080230004655	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
1080230004656	metal ion-dependent adhesion site (MIDAS); other site
1080230004657	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230004658	Coenzyme A binding pocket [chemical binding]; other site
1080230004659	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230004660	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230004661	Domain of unknown function DUF21; Region: DUF21; pfam01595
1080230004662	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1080230004663	Protein of unknown function, DUF1537; Region: DUF1537; cl01345
1080230004664	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
1080230004665	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
1080230004666	FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441
1080230004667	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1080230004668	DHH family; Region: DHH; pfam01368
1080230004669	FOG: CBS domain [General function prediction only]; Region: COG0517
1080230004670	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
1080230004671	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1080230004672	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1080230004673	active site
1080230004674	NTP binding site [chemical binding]; other site
1080230004675	metal binding triad [ion binding]; metal-binding site
1080230004676	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1080230004677	photosystem II S4 domain protein; Region: PS_II_S4; TIGR03069
1080230004678	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1080230004679	RNA binding surface [nucleotide binding]; other site
1080230004680	Permease; Region: Permease; cl00510
1080230004681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004682	TPR repeat; Region: TPR_11; pfam13414
1080230004683	binding surface
1080230004684	TPR motif; other site
1080230004685	TPR repeat; Region: TPR_11; pfam13414
1080230004686	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004687	binding surface
1080230004688	TPR motif; other site
1080230004689	TPR repeat; Region: TPR_11; pfam13414
1080230004690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004691	binding surface
1080230004692	TPR motif; other site
1080230004693	TPR repeat; Region: TPR_11; pfam13414
1080230004694	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230004695	putative active site [active]
1080230004696	bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477
1080230004697	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1080230004698	active site
1080230004699	ATP-binding site [chemical binding]; other site
1080230004700	pantoate-binding site; other site
1080230004701	HXXH motif; other site
1080230004702	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1080230004703	CMP-binding site; other site
1080230004704	The sites determining sugar specificity; other site
1080230004705	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1080230004706	active site clefts [active]
1080230004707	zinc binding site [ion binding]; other site
1080230004708	dimer interface [polypeptide binding]; other site
1080230004709	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1080230004710	serine O-acetyltransferase; Region: cysE; TIGR01172
1080230004711	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1080230004712	trimer interface [polypeptide binding]; other site
1080230004713	active site
1080230004714	substrate binding site [chemical binding]; other site
1080230004715	CoA binding site [chemical binding]; other site
1080230004716	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14096
1080230004717	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1080230004718	active site
1080230004719	dimer interface [polypeptide binding]; other site
1080230004720	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1080230004721	dimer interface [polypeptide binding]; other site
1080230004722	active site
1080230004723	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1080230004724	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1080230004725	putative di-iron ligands [ion binding]; other site
1080230004726	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1080230004727	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
1080230004728	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1080230004729	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1080230004730	Cytochrome c; Region: Cytochrom_C; cl11414
1080230004731	Cytochrome c; Region: Cytochrom_C; cl11414
1080230004732	ribosomal protein L9; Region: L9; TIGR00158
1080230004733	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1080230004734	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1080230004735	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1080230004736	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1080230004737	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
1080230004738	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004739	TPR motif; other site
1080230004740	binding surface
1080230004741	GUN4-like; Region: GUN4; pfam05419
1080230004742	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1080230004743	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1080230004744	trimer interface [polypeptide binding]; other site
1080230004745	active site
1080230004746	substrate binding site [chemical binding]; other site
1080230004747	CoA binding site [chemical binding]; other site
1080230004748	HupF/HypC family; Region: HupF_HypC; cl00394
1080230004749	UbiA prenyltransferase family; Region: UbiA; cl00337
1080230004750	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1080230004751	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
1080230004752	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1080230004753	active site
1080230004754	substrate binding site [chemical binding]; other site
1080230004755	catalytic site [active]
1080230004756	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230004757	EVE domain; Region: EVE; cl00728
1080230004758	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230004759	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
1080230004760	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1080230004761	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230004762	phosphopeptide binding site; other site
1080230004763	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230004764	metal binding site [ion binding]; metal-binding site
1080230004765	active site
1080230004766	I-site; other site
1080230004767	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230004768	Orange carotenoid protein, N-terminal; Region: Carot_N; pfam09150
1080230004769	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1080230004770	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein; Provisional; Region: PRK09319
1080230004771	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
1080230004772	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1080230004773	dimerization interface [polypeptide binding]; other site
1080230004774	active site
1080230004775	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
1080230004776	catalytic residue [active]
1080230004777	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1080230004778	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1080230004779	substrate binding site [chemical binding]; other site
1080230004780	glutamase interaction surface [polypeptide binding]; other site
1080230004781	FecR protein; Region: FecR; pfam04773
1080230004782	Fe2+-dicitrate sensor, membrane component [Inorganic ion transport and metabolism / Signal transduction mechanisms]; Region: FecR; COG3712
1080230004783	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004784	binding surface
1080230004785	TPR motif; other site
1080230004786	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230004787	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230004788	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230004789	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230004790	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004791	binding surface
1080230004792	TPR motif; other site
1080230004793	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1080230004794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1080230004795	CHAT domain; Region: CHAT; pfam12770
1080230004796	Domain of Unknown Function (DUF928); Region: DUF928; pfam06051
1080230004797	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1080230004798	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230004799	GAF domain; Region: GAF; cl15785
1080230004800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230004801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004802	dimer interface [polypeptide binding]; other site
1080230004803	phosphorylation site [posttranslational modification]
1080230004804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004805	ATP binding site [chemical binding]; other site
1080230004806	Mg2+ binding site [ion binding]; other site
1080230004807	G-X-G motif; other site
1080230004808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
1080230004809	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230004810	Late competence development protein ComFB; Region: ComFB; pfam10719
1080230004811	Peptidase family M48; Region: Peptidase_M48; cl12018
1080230004812	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230004813	GAF domain; Region: GAF; cl15785
1080230004814	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004815	dimer interface [polypeptide binding]; other site
1080230004816	phosphorylation site [posttranslational modification]
1080230004817	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004818	ATP binding site [chemical binding]; other site
1080230004819	Mg2+ binding site [ion binding]; other site
1080230004820	G-X-G motif; other site
1080230004821	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1080230004822	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1080230004823	putative active site [active]
1080230004824	Dihaem cytochrome c; Region: DHC; pfam09626
1080230004825	Protein of unknown function (DUF3187); Region: DUF3187; pfam11383
1080230004826	GTP-binding protein Der; Reviewed; Region: PRK00093
1080230004827	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1080230004828	G1 box; other site
1080230004829	GTP/Mg2+ binding site [chemical binding]; other site
1080230004830	Switch I region; other site
1080230004831	G2 box; other site
1080230004832	Switch II region; other site
1080230004833	G3 box; other site
1080230004834	G4 box; other site
1080230004835	G5 box; other site
1080230004836	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1080230004837	G1 box; other site
1080230004838	GTP/Mg2+ binding site [chemical binding]; other site
1080230004839	Switch I region; other site
1080230004840	G2 box; other site
1080230004841	G3 box; other site
1080230004842	Switch II region; other site
1080230004843	G4 box; other site
1080230004844	G5 box; other site
1080230004845	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1080230004846	heterotetramer interface [polypeptide binding]; other site
1080230004847	active site pocket [active]
1080230004848	cleavage site
1080230004849	TPR repeat; Region: TPR_11; pfam13414
1080230004850	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004851	binding surface
1080230004852	TPR motif; other site
1080230004853	TPR repeat; Region: TPR_11; pfam13414
1080230004854	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230004855	binding surface
1080230004856	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1080230004857	TPR motif; other site
1080230004858	N-acyl-D-glucosamine 2-epimerase [Carbohydrate transport and metabolism]; Region: COG2942
1080230004859	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249
1080230004860	dimerization interface [polypeptide binding]; other site
1080230004861	putative active cleft [active]
1080230004862	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
1080230004863	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004864	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004865	active site
1080230004866	phosphorylation site [posttranslational modification]
1080230004867	intermolecular recognition site; other site
1080230004868	dimerization interface [polypeptide binding]; other site
1080230004869	Protein of unknown function (DUF3685); Region: DUF3685; pfam12452
1080230004870	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1080230004871	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230004872	Walker A/P-loop; other site
1080230004873	ATP binding site [chemical binding]; other site
1080230004874	Q-loop/lid; other site
1080230004875	ABC transporter signature motif; other site
1080230004876	Walker B; other site
1080230004877	D-loop; other site
1080230004878	H-loop/switch region; other site
1080230004879	TOBE domain; Region: TOBE_2; cl01440
1080230004880	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1080230004881	Cobalt transport protein; Region: CbiQ; cl00463
1080230004882	anthranilate synthase component I-like protein; Validated; Region: PRK05940
1080230004883	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1080230004884	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1080230004885	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
1080230004886	oxygen-independent coproporphyrinogen III oxidase; Region: hemN; TIGR00538
1080230004887	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230004888	FeS/SAM binding site; other site
1080230004889	HemN C-terminal domain; Region: HemN_C; pfam06969
1080230004890	Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232
1080230004891	heme binding pocket [chemical binding]; other site
1080230004892	heme ligand [chemical binding]; other site
1080230004893	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1080230004894	dinuclear metal binding motif [ion binding]; other site
1080230004895	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
1080230004896	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
1080230004897	nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600
1080230004898	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1080230004899	dimerization interface [polypeptide binding]; other site
1080230004900	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004901	dimer interface [polypeptide binding]; other site
1080230004902	phosphorylation site [posttranslational modification]
1080230004903	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230004904	ATP binding site [chemical binding]; other site
1080230004905	Mg2+ binding site [ion binding]; other site
1080230004906	G-X-G motif; other site
1080230004907	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004908	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004909	active site
1080230004910	phosphorylation site [posttranslational modification]
1080230004911	intermolecular recognition site; other site
1080230004912	dimerization interface [polypeptide binding]; other site
1080230004913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230004914	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230004915	dimer interface [polypeptide binding]; other site
1080230004916	phosphorylation site [posttranslational modification]
1080230004917	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230004918	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230004919	active site
1080230004920	phosphorylation site [posttranslational modification]
1080230004921	intermolecular recognition site; other site
1080230004922	dimerization interface [polypeptide binding]; other site
1080230004923	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
1080230004924	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1080230004925	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1080230004926	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
1080230004927	Walker A/P-loop; other site
1080230004928	ATP binding site [chemical binding]; other site
1080230004929	Q-loop/lid; other site
1080230004930	ABC transporter signature motif; other site
1080230004931	Walker B; other site
1080230004932	D-loop; other site
1080230004933	H-loop/switch region; other site
1080230004934	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1080230004935	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1080230004936	iron-sulfur cluster [ion binding]; other site
1080230004937	[2Fe-2S] cluster binding site [ion binding]; other site
1080230004938	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1080230004939	hydrophobic ligand binding site; other site
1080230004940	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1080230004941	RNA binding site [nucleotide binding]; other site
1080230004942	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1080230004943	RNA binding site [nucleotide binding]; other site
1080230004944	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
1080230004945	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1080230004946	RNA binding site [nucleotide binding]; other site
1080230004947	domain interface; other site
1080230004948	DNA primase; Validated; Region: dnaG; PRK05667
1080230004949	CHC2 zinc finger; Region: zf-CHC2; cl15369
1080230004950	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1080230004951	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1080230004952	active site
1080230004953	metal binding site [ion binding]; metal-binding site
1080230004954	interdomain interaction site; other site
1080230004955	D1 subunit  of photosystem II (PS II); Region: Photosystem-II_D1; cd09289
1080230004956	protein I interface; other site
1080230004957	D2 interface; other site
1080230004958	protein T interface; other site
1080230004959	chlorophyll binding site; other site
1080230004960	beta carotene binding site; other site
1080230004961	pheophytin binding site; other site
1080230004962	manganese-stabilizing polypeptide interface; other site
1080230004963	CP43 interface; other site
1080230004964	protein L interface; other site
1080230004965	oxygen evolving complex binding site; other site
1080230004966	bromide binding site; other site
1080230004967	quinone binding site; other site
1080230004968	Fe binding site [ion binding]; other site
1080230004969	core light harvesting interface; other site
1080230004970	cytochrome b559 alpha subunit interface; other site
1080230004971	cytochrome c-550 interface; other site
1080230004972	protein J interface; other site
1080230004973	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1080230004974	Repair protein; Region: Repair_PSII; cl01535
1080230004975	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1080230004976	Ligand Binding Site [chemical binding]; other site
1080230004977	Cytochrome B6-F complex subunit 5; Region: PetG; cl03637
1080230004978	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1080230004979	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1080230004980	active site
1080230004981	metal binding site [ion binding]; metal-binding site
1080230004982	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1080230004983	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
1080230004984	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1080230004985	EVE domain; Region: EVE; cl00728
1080230004986	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
1080230004987	Ribonuclease P; Region: Ribonuclease_P; cl00457
1080230004988	Bacterial PH domain; Region: DUF304; cl01348
1080230004989	putative inner membrane protein translocase component YidC; Provisional; Region: PRK02654
1080230004990	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1080230004991	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1080230004992	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1080230004993	G-X-X-G motif; other site
1080230004994	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1080230004995	RxxxH motif; other site
1080230004996	DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214
1080230004997	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1080230004998	HSP70 interaction site [polypeptide binding]; other site
1080230004999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230005000	binding surface
1080230005001	TPR motif; other site
1080230005002	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1080230005003	active site
1080230005004	dimerization interface [polypeptide binding]; other site
1080230005005	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230005006	catalytic loop [active]
1080230005007	iron binding site [ion binding]; other site
1080230005008	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1080230005009	NlpC/P60 family; Region: NLPC_P60; cl11438
1080230005010	GUN4-like; Region: GUN4; pfam05419
1080230005011	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1080230005012	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1080230005013	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005014	Protein of unknown function (DUF1838); Region: DUF1838; pfam08894
1080230005015	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
1080230005016	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1080230005017	DXD motif; other site
1080230005018	Integral membrane protein DUF95; Region: DUF95; cl00572
1080230005019	bifunctional sterol desaturase/short chain dehydrogenase; Validated; Region: PRK07424
1080230005020	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1080230005021	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005022	NAD(P) binding site [chemical binding]; other site
1080230005023	active site
1080230005024	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1080230005025	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230005026	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
1080230005027	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1080230005028	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230005029	ligand binding site [chemical binding]; other site
1080230005030	flexible hinge region; other site
1080230005031	Helix-turn-helix domains; Region: HTH; cl00088
1080230005032	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1080230005033	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1080230005034	Substrate binding site; other site
1080230005035	Cupin domain; Region: Cupin_2; cl09118
1080230005036	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1080230005037	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230005038	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230005039	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1080230005040	iron-sulfur cluster [ion binding]; other site
1080230005041	[2Fe-2S] cluster binding site [ion binding]; other site
1080230005042	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1080230005043	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230005044	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230005045	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230005046	ligand binding site [chemical binding]; other site
1080230005047	flexible hinge region; other site
1080230005048	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1080230005049	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic). The cleavage...; Region: Peptidase_C39_like; cd02259
1080230005050	putative active site [active]
1080230005051	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230005052	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005053	Walker A/P-loop; other site
1080230005054	ATP binding site [chemical binding]; other site
1080230005055	Q-loop/lid; other site
1080230005056	ABC transporter signature motif; other site
1080230005057	Walker B; other site
1080230005058	D-loop; other site
1080230005059	H-loop/switch region; other site
1080230005060	DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625
1080230005061	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1080230005062	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
1080230005063	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1080230005064	Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192
1080230005065	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1080230005066	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1080230005067	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1080230005068	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040
1080230005069	gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066
1080230005070	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
1080230005071	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1080230005072	S-layer homology domain; Region: SLH; pfam00395
1080230005073	type IV pilus assembly protein PilM; Region: pilM; TIGR01175
1080230005074	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
1080230005075	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
1080230005076	Pilus assembly protein, PilO; Region: PilO; cl01234
1080230005077	Type II secretory pathway, component HofQ [Intracellular trafficking and secretion]; Region: HofQ; COG4796
1080230005078	Secretin and TonB N terminus short domain; Region: STN; cl06624
1080230005079	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
1080230005080	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1080230005081	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230005082	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230005083	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1080230005084	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1080230005085	Ligand Binding Site [chemical binding]; other site
1080230005086	threonine synthase; Reviewed; Region: PRK06721
1080230005087	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1080230005088	homodimer interface [polypeptide binding]; other site
1080230005089	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230005090	catalytic residue [active]
1080230005091	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
1080230005092	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
1080230005093	NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377
1080230005094	NADH dehydrogenase subunit J; Provisional; Region: PRK12494
1080230005095	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1080230005096	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230005097	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1080230005098	Integrase core domain; Region: rve; cl01316
1080230005099	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
1080230005100	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230005101	PAS domain; Region: PAS_9; pfam13426
1080230005102	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230005103	metal binding site [ion binding]; metal-binding site
1080230005104	active site
1080230005105	I-site; other site
1080230005106	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1080230005107	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230005108	ligand binding site [chemical binding]; other site
1080230005109	flexible hinge region; other site
1080230005110	Helix-turn-helix domains; Region: HTH; cl00088
1080230005111	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230005112	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230005113	Protein of unknown function (DUF3326); Region: DUF3326; pfam11805
1080230005114	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1080230005115	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
1080230005116	Domain of unknown function (DUF4359); Region: DUF4359; pfam14271
1080230005117	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1080230005118	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005119	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005120	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005121	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005122	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005123	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005124	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005125	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1080230005126	substrate binding site [chemical binding]; other site
1080230005127	CTP synthetase; Validated; Region: pyrG; PRK05380
1080230005128	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1080230005129	Catalytic site [active]
1080230005130	active site
1080230005131	UTP binding site [chemical binding]; other site
1080230005132	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1080230005133	active site
1080230005134	putative oxyanion hole; other site
1080230005135	catalytic triad [active]
1080230005136	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230005137	ligand binding site [chemical binding]; other site
1080230005138	flexible hinge region; other site
1080230005139	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
1080230005140	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005141	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
1080230005142	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1080230005143	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1080230005144	omega-6 fatty acid desaturase; Region: PLN02505
1080230005145	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1080230005146	putative di-iron ligands [ion binding]; other site
1080230005147	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1080230005148	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1080230005149	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1080230005150	ScpA/B protein; Region: ScpA_ScpB; cl00598
1080230005151	signal recognition particle protein; Provisional; Region: PRK10867
1080230005152	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
1080230005153	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1080230005154	P loop; other site
1080230005155	GTP binding site [chemical binding]; other site
1080230005156	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1080230005157	Integrase core domain; Region: rve; cl01316
1080230005158	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230005159	Helix-turn-helix domains; Region: HTH; cl00088
1080230005160	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1080230005161	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1080230005162	GatB domain; Region: GatB_Yqey; cl11497
1080230005163	Transglycosylase; Region: Transgly; cl07896
1080230005164	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1080230005165	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230005166	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
1080230005167	putative carbohydrate kinase; Provisional; Region: PRK10565
1080230005168	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1080230005169	putative substrate binding site [chemical binding]; other site
1080230005170	putative ATP binding site [chemical binding]; other site
1080230005171	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005172	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1080230005173	dimer interface [polypeptide binding]; other site
1080230005174	catalytic triad [active]
1080230005175	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1080230005176	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005177	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005178	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005179	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005180	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005181	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1080230005182	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230005183	substrate binding pocket [chemical binding]; other site
1080230005184	membrane-bound complex binding site; other site
1080230005185	hinge residues; other site
1080230005186	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
1080230005187	DctM-like transporters; Region: DctM; pfam06808
1080230005188	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
1080230005189	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
1080230005190	elongation factor Tu; Reviewed; Region: PRK00049
1080230005191	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1080230005192	G1 box; other site
1080230005193	GEF interaction site [polypeptide binding]; other site
1080230005194	GTP/Mg2+ binding site [chemical binding]; other site
1080230005195	Switch I region; other site
1080230005196	G2 box; other site
1080230005197	G3 box; other site
1080230005198	Switch II region; other site
1080230005199	G4 box; other site
1080230005200	G5 box; other site
1080230005201	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1080230005202	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1080230005203	Antibiotic Binding Site [chemical binding]; other site
1080230005204	elongation factor G; Reviewed; Region: PRK00007
1080230005205	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1080230005206	G1 box; other site
1080230005207	putative GEF interaction site [polypeptide binding]; other site
1080230005208	GTP/Mg2+ binding site [chemical binding]; other site
1080230005209	Switch I region; other site
1080230005210	G2 box; other site
1080230005211	G3 box; other site
1080230005212	Switch II region; other site
1080230005213	G4 box; other site
1080230005214	G5 box; other site
1080230005215	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1080230005216	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1080230005217	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1080230005218	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
1080230005219	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1080230005220	S17 interaction site [polypeptide binding]; other site
1080230005221	S8 interaction site; other site
1080230005222	16S rRNA interaction site [nucleotide binding]; other site
1080230005223	streptomycin interaction site [chemical binding]; other site
1080230005224	23S rRNA interaction site [nucleotide binding]; other site
1080230005225	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1080230005226	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230005227	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1080230005228	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1080230005229	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230005230	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1080230005231	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
1080230005232	Integrase core domain; Region: rve; cl01316
1080230005233	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1080230005234	nucleoside/Zn binding site; other site
1080230005235	dimer interface [polypeptide binding]; other site
1080230005236	catalytic motif [active]
1080230005237	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1080230005238	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1080230005239	Carbohydrate-selective porin [Cell envelope biogenesis, outer membrane]; Region: OprB; COG3659
1080230005240	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230005241	ATP cone domain; Region: ATP-cone; pfam03477
1080230005242	ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506
1080230005243	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1080230005244	active site
1080230005245	dimer interface [polypeptide binding]; other site
1080230005246	catalytic residues [active]
1080230005247	effector binding site; other site
1080230005248	R2 peptide binding site; other site
1080230005249	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1080230005250	ATP-sulfurylase; Region: ATPS; cd00517
1080230005251	active site
1080230005252	HXXH motif; other site
1080230005253	flexible loop; other site
1080230005254	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
1080230005255	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230005256	putative ADP-binding pocket [chemical binding]; other site
1080230005257	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1080230005258	putative active site [active]
1080230005259	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
1080230005260	geranylgeranyl diphosphate reductase; Provisional; Region: PLN00093
1080230005261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005262	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1080230005263	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
1080230005264	putative active site [active]
1080230005265	metal binding site [ion binding]; metal-binding site
1080230005266	Protein of unknown function (DUF433); Region: DUF433; cl01030
1080230005267	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
1080230005268	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1080230005269	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1080230005270	catalytic residues [active]
1080230005271	dimer interface [polypeptide binding]; other site
1080230005272	Na(+)/iodide (NIS) and Na(+)/multivitamin (SMVT) cotransporters, and related proteins; solute binding domain; Region: SLC5sbd_NIS-like; cd10326
1080230005273	Na binding site [ion binding]; other site
1080230005274	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
1080230005275	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1080230005276	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1080230005277	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1080230005278	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
1080230005279	glucosylglycerol-phosphate synthase; Region: gluc_glyc_Psyn; TIGR02398
1080230005280	active site
1080230005281	homotetramer interface [polypeptide binding]; other site
1080230005282	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1080230005283	glycerol kinase; Region: glycerol_kin; TIGR01311
1080230005284	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1080230005285	N- and C-terminal domain interface [polypeptide binding]; other site
1080230005286	active site
1080230005287	MgATP binding site [chemical binding]; other site
1080230005288	catalytic site [active]
1080230005289	metal binding site [ion binding]; metal-binding site
1080230005290	glycerol binding site [chemical binding]; other site
1080230005291	homotetramer interface [polypeptide binding]; other site
1080230005292	homodimer interface [polypeptide binding]; other site
1080230005293	FBP binding site [chemical binding]; other site
1080230005294	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1080230005295	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1080230005296	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1080230005297	Protein of unknown function (DUF760); Region: DUF760; pfam05542
1080230005298	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
1080230005299	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
1080230005300	Protein of unknown function (DUF4079); Region: DUF4079; pfam13301
1080230005301	Lipid A disaccharide synthetase [Cell envelope biogenesis, outer membrane]; Region: LpxB; COG0763
1080230005302	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
1080230005303	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
1080230005304	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
1080230005305	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1080230005306	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
1080230005307	active site
1080230005308	catalytic residues [active]
1080230005309	metal binding site [ion binding]; metal-binding site
1080230005310	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
1080230005311	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005312	ABC transporter signature motif; other site
1080230005313	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230005314	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1080230005315	Proline dehydrogenase; Region: Pro_dh; cl03282
1080230005316	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1080230005317	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1080230005318	Glutamate binding site [chemical binding]; other site
1080230005319	homodimer interface [polypeptide binding]; other site
1080230005320	NAD binding site [chemical binding]; other site
1080230005321	catalytic residues [active]
1080230005322	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230005323	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230005324	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230005325	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230005326	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230005327	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1080230005328	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1080230005329	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1080230005330	catalytic residue [active]
1080230005331	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
1080230005332	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230005333	catalytic loop [active]
1080230005334	iron binding site [ion binding]; other site
1080230005335	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1080230005336	PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388
1080230005337	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1080230005338	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1080230005339	active site
1080230005340	Substrate binding site; other site
1080230005341	Mg++ binding site; other site
1080230005342	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1080230005343	putative trimer interface [polypeptide binding]; other site
1080230005344	putative CoA binding site [chemical binding]; other site
1080230005345	Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074
1080230005346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005347	CoA-ligase; Region: Ligase_CoA; cl02894
1080230005348	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1080230005349	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1080230005350	homotetramer interface [polypeptide binding]; other site
1080230005351	FMN binding site [chemical binding]; other site
1080230005352	homodimer contacts [polypeptide binding]; other site
1080230005353	putative active site [active]
1080230005354	putative substrate binding site [chemical binding]; other site
1080230005355	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230005356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230005357	active site
1080230005358	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230005359	phosphorylation site [posttranslational modification]
1080230005360	intermolecular recognition site; other site
1080230005361	dimerization interface [polypeptide binding]; other site
1080230005362	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230005363	dimer interface [polypeptide binding]; other site
1080230005364	phosphorylation site [posttranslational modification]
1080230005365	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230005366	ATP binding site [chemical binding]; other site
1080230005367	Mg2+ binding site [ion binding]; other site
1080230005368	G-X-G motif; other site
1080230005369	Photosystem I reaction centre subunit IV / PsaE; Region: PSI_PsaE; cl03585
1080230005370	formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945
1080230005371	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1080230005372	DNA binding site [nucleotide binding]
1080230005373	catalytic residue [active]
1080230005374	H2TH interface [polypeptide binding]; other site
1080230005375	putative catalytic residues [active]
1080230005376	turnover-facilitating residue; other site
1080230005377	intercalation triad [nucleotide binding]; other site
1080230005378	8OG recognition residue [nucleotide binding]; other site
1080230005379	putative reading head residues; other site
1080230005380	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1080230005381	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1080230005382	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1080230005383	NAD synthetase; Provisional; Region: PRK13981
1080230005384	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1080230005385	multimer interface [polypeptide binding]; other site
1080230005386	active site
1080230005387	catalytic triad [active]
1080230005388	protein interface 1 [polypeptide binding]; other site
1080230005389	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1080230005390	homodimer interface [polypeptide binding]; other site
1080230005391	NAD binding pocket [chemical binding]; other site
1080230005392	ATP binding pocket [chemical binding]; other site
1080230005393	Mg binding site [ion binding]; other site
1080230005394	active-site loop [active]
1080230005395	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230005396	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230005397	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230005398	active site
1080230005399	phosphorylation site [posttranslational modification]
1080230005400	intermolecular recognition site; other site
1080230005401	dimerization interface [polypeptide binding]; other site
1080230005402	Sensors of blue-light using FAD; Region: BLUF; cl04855
1080230005403	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1080230005404	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1080230005405	putative tRNA-binding site [nucleotide binding]; other site
1080230005406	B3/4 domain; Region: B3_4; cl11458
1080230005407	tRNA synthetase B5 domain; Region: B5; cl08394
1080230005408	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1080230005409	dimer interface [polypeptide binding]; other site
1080230005410	motif 1; other site
1080230005411	motif 3; other site
1080230005412	motif 2; other site
1080230005413	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
1080230005414	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1080230005415	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1080230005416	active site
1080230005417	ATP binding site [chemical binding]; other site
1080230005418	substrate binding site [chemical binding]; other site
1080230005419	activation loop (A-loop); other site
1080230005420	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005421	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230005422	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005423	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1080230005424	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230005425	active site
1080230005426	phosphorylation site [posttranslational modification]
1080230005427	intermolecular recognition site; other site
1080230005428	dimerization interface [polypeptide binding]; other site
1080230005429	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230005430	DNA binding residues [nucleotide binding]
1080230005431	dimerization interface [polypeptide binding]; other site
1080230005432	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1080230005433	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656
1080230005434	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
1080230005435	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK07428
1080230005436	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1080230005437	dimerization interface [polypeptide binding]; other site
1080230005438	active site
1080230005439	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1080230005440	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1080230005441	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1080230005442	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1080230005443	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
1080230005444	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1080230005445	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1080230005446	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1080230005447	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1080230005448	9,9'-di-cis-zeta-carotene desaturase; Region: zeta_caro_desat; TIGR02732
1080230005449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005451	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_8; cd07817
1080230005452	putative hydrophobic ligand binding site [chemical binding]; other site
1080230005453	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1080230005454	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1080230005455	active site
1080230005456	catalytic tetrad [active]
1080230005457	Fructose-1.6-bisphosphate aldolase found in gram +/- bacteria; Region: FBP_aldolase_I_bact; cd00949
1080230005458	putative active site [active]
1080230005459	catalytic residue [active]
1080230005460	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1080230005461	oxyanion hole [active]
1080230005462	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
1080230005463	Membrane transport protein; Region: Mem_trans; cl09117
1080230005464	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1080230005465	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1080230005466	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1080230005467	active site
1080230005468	Ycf27; Reviewed; Region: orf27; CHL00148
1080230005469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230005470	active site
1080230005471	phosphorylation site [posttranslational modification]
1080230005472	intermolecular recognition site; other site
1080230005473	dimerization interface [polypeptide binding]; other site
1080230005474	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230005475	DNA binding site [nucleotide binding]
1080230005476	Protein of unknown function (DUF2930); Region: DUF2930; pfam11152
1080230005477	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230005478	putative active site [active]
1080230005479	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1080230005480	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005481	Walker A/P-loop; other site
1080230005482	ATP binding site [chemical binding]; other site
1080230005483	Q-loop/lid; other site
1080230005484	ABC transporter signature motif; other site
1080230005485	Walker B; other site
1080230005486	D-loop; other site
1080230005487	H-loop/switch region; other site
1080230005488	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
1080230005489	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1080230005490	TM-ABC transporter signature motif; other site
1080230005491	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1080230005492	hemolysin TlyA family protein; Region: tly; TIGR00478
1080230005493	RNA binding surface [nucleotide binding]; other site
1080230005494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230005495	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1080230005496	binding surface
1080230005497	TPR motif; other site
1080230005498	TPR repeat; Region: TPR_11; pfam13414
1080230005499	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230005500	TPR motif; other site
1080230005501	binding surface
1080230005502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230005503	binding surface
1080230005504	TPR repeat; Region: TPR_11; pfam13414
1080230005505	TPR motif; other site
1080230005506	TPR repeat; Region: TPR_11; pfam13414
1080230005507	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
1080230005508	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542
1080230005509	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1080230005510	substrate binding site; other site
1080230005511	dimer interface; other site
1080230005512	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
1080230005513	AMP binding site [chemical binding]; other site
1080230005514	metal binding site [ion binding]; metal-binding site
1080230005515	active site
1080230005516	sucrose-6F-phosphate phosphohydrolase; Region: SPP_plant-cyano; TIGR01485
1080230005517	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230005518	active site
1080230005519	motif I; other site
1080230005520	motif II; other site
1080230005521	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230005522	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1080230005523	anti sigma factor interaction site; other site
1080230005524	regulatory phosphorylation site [posttranslational modification]; other site
1080230005525	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
1080230005526	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1080230005527	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
1080230005528	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1080230005529	Domain of unknown function (DUF1816); Region: DUF1816; pfam08846
1080230005530	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1080230005531	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1080230005532	active site
1080230005533	HIGH motif; other site
1080230005534	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1080230005535	KMSKS motif; other site
1080230005536	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1080230005537	tRNA binding surface [nucleotide binding]; other site
1080230005538	anticodon binding site; other site
1080230005539	Maf-like protein; Region: Maf; pfam02545
1080230005540	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1080230005541	active site
1080230005542	dimer interface [polypeptide binding]; other site
1080230005543	CAAX protease self-immunity; Region: Abi; cl00558
1080230005544	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1080230005545	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
1080230005546	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; cl00933
1080230005547	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1080230005548	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
1080230005549	Ligand binding site; other site
1080230005550	Putative Catalytic site; other site
1080230005551	DXD motif; other site
1080230005552	GtrA-like protein; Region: GtrA; cl00971
1080230005553	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
1080230005554	dimer interface [polypeptide binding]; other site
1080230005555	substrate binding site [chemical binding]; other site
1080230005556	metal binding sites [ion binding]; metal-binding site
1080230005557	Cyanobacterial and plastid NDH-1 subunit M; Region: NdhM; pfam10664
1080230005558	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1080230005559	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_37; cd04696
1080230005560	nudix motif; other site
1080230005561	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1080230005562	homooctamer interface [polypeptide binding]; other site
1080230005563	active site
1080230005564	LysE type translocator; Region: LysE; cl00565
1080230005565	hypothetical protein; Validated; Region: PRK07411
1080230005566	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1080230005567	ATP binding site [chemical binding]; other site
1080230005568	substrate interface [chemical binding]; other site
1080230005569	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1080230005570	active site residue [active]
1080230005571	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; cl01467
1080230005572	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1080230005573	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1080230005574	RNA binding surface [nucleotide binding]; other site
1080230005575	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1080230005576	active site
1080230005577	Bacterial sugar transferase; Region: Bac_transf; cl00939
1080230005578	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230005579	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
1080230005580	putative ADP-binding pocket [chemical binding]; other site
1080230005581	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
1080230005582	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
1080230005583	Walker A motif; other site
1080230005584	ATP binding site [chemical binding]; other site
1080230005585	Walker B motif; other site
1080230005586	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
1080230005587	Domain of unknown function (DUF309); Region: DUF309; cl00667
1080230005588	Protein of unknown function (DUF760); Region: DUF760; pfam05542
1080230005589	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1080230005590	SmpB-tmRNA interface; other site
1080230005591	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230005592	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230005593	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230005594	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1080230005595	active site
1080230005596	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230005597	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230005598	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230005599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230005600	S-adenosylmethionine binding site [chemical binding]; other site
1080230005601	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
1080230005602	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1080230005603	Clp amino terminal domain; Region: Clp_N; pfam02861
1080230005604	Clp amino terminal domain; Region: Clp_N; pfam02861
1080230005605	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230005606	Walker A motif; other site
1080230005607	ATP binding site [chemical binding]; other site
1080230005608	Walker B motif; other site
1080230005609	arginine finger; other site
1080230005610	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230005611	Walker A motif; other site
1080230005612	ATP binding site [chemical binding]; other site
1080230005613	Walker B motif; other site
1080230005614	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1080230005615	phosphoribulokinase; Provisional; Region: PRK07429
1080230005616	Phosphoribulokinase (PRK) is an enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. This enzyme catalyzes the phosphorylation of D-ribulose 5-phosphate to form D-ribulose 1, 5-biphosphate, using ATP and NADPH...; Region: PRK; cd02026
1080230005617	active site
1080230005618	CpcD/allophycocyanin linker domain; Region: CpcD; cl03191
1080230005619	ferredoxin--NADP+ reductase; Provisional; Region: PLN03116
1080230005620	These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer...; Region: CYPOR_like_FNR; cd06208
1080230005621	dimerization interface [polypeptide binding]; other site
1080230005622	FAD binding pocket [chemical binding]; other site
1080230005623	FAD binding motif [chemical binding]; other site
1080230005624	catalytic residues [active]
1080230005625	NAD binding pocket [chemical binding]; other site
1080230005626	phosphate binding motif [ion binding]; other site
1080230005627	beta-alpha-beta structure motif; other site
1080230005628	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230005629	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1080230005630	active site
1080230005631	motif I; other site
1080230005632	motif II; other site
1080230005633	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230005634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230005635	binding surface
1080230005636	TPR motif; other site
1080230005637	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230005638	binding surface
1080230005639	TPR motif; other site
1080230005640	TPR repeat; Region: TPR_11; pfam13414
1080230005641	Photosystem II Pbs27; Region: PSII_Pbs27; cl11841
1080230005642	ribonuclease III; Reviewed; Region: rnc; PRK00102
1080230005643	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1080230005644	dimerization interface [polypeptide binding]; other site
1080230005645	active site
1080230005646	metal binding site [ion binding]; metal-binding site
1080230005647	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1080230005648	dsRNA binding site [nucleotide binding]; other site
1080230005649	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
1080230005650	Lignostilbene-alpha,beta-dioxygenase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3670
1080230005651	Retinal pigment epithelial membrane protein; Region: RPE65; cl10080
1080230005652	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1080230005653	CpeT/CpcT family (DUF1001); Region: CpeT; pfam06206
1080230005654	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1080230005655	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1080230005656	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230005657	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1080230005658	Flavin Reductases; Region: FlaRed; cl00801
1080230005659	DNA repair protein RecN; Region: recN; TIGR00634
1080230005660	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
1080230005661	Walker A/P-loop; other site
1080230005662	ATP binding site [chemical binding]; other site
1080230005663	Q-loop/lid; other site
1080230005664	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
1080230005665	ABC transporter signature motif; other site
1080230005666	Walker B; other site
1080230005667	D-loop; other site
1080230005668	H-loop/switch region; other site
1080230005669	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
1080230005670	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
1080230005671	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230005672	putative active site [active]
1080230005673	Protein of unknown function (DUF497); Region: DUF497; cl01108
1080230005674	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1080230005675	Manganese-stabilising protein / photosystem II polypeptide; Region: MSP; cl03326
1080230005676	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1080230005677	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
1080230005678	hinge; other site
1080230005679	active site
1080230005680	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1080230005681	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
1080230005682	B12 binding site [chemical binding]; other site
1080230005683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1080230005684	FeS/SAM binding site; other site
1080230005685	Taspase1_like domains; Taspase1 catalyzes the cleavage of the mix lineage leukemia (MLL) nuclear protein and transcription factor TFIIA. Taspase1 is a threonine aspartase, a member of the Ntn hydrolase superfamily and the type 2 asparaginase family. A...; Region: Taspase1_like; cd04514
1080230005686	active site
1080230005687	dimer interface [polypeptide binding]; other site
1080230005688	catalytic nucleophile [active]
1080230005689	adenylosuccinate lyase; Provisional; Region: PRK07380
1080230005690	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1080230005691	tetramer interface [polypeptide binding]; other site
1080230005692	active site
1080230005693	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1080230005694	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230005695	putative active site [active]
1080230005696	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1080230005697	gamma-beta subunit interface [polypeptide binding]; other site
1080230005698	alpha-beta subunit interface [polypeptide binding]; other site
1080230005699	tocopherol O-methyltransferase; Region: PLN02244
1080230005700	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230005701	S-adenosylmethionine binding site [chemical binding]; other site
1080230005702	DNA polymerase III subunit delta'; Validated; Region: PRK07399
1080230005703	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005704	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005705	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1080230005706	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1080230005707	putative ligand binding site [chemical binding]; other site
1080230005708	DNA repair protein RadA; Region: sms; TIGR00416
1080230005709	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1080230005710	Walker A motif/ATP binding site; other site
1080230005711	ATP binding site [chemical binding]; other site
1080230005712	Walker B motif; other site
1080230005713	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
1080230005714	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005715	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230005716	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005717	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230005718	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1080230005719	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1080230005720	Protein of unknown function (DUF2996); Region: DUF2996; pfam11210
1080230005721	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1080230005722	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1080230005723	putative RNA binding site [nucleotide binding]; other site
1080230005724	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1080230005725	primosome assembly protein PriA; Validated; Region: PRK05580
1080230005726	primosome assembly protein PriA; Validated; Region: PRK05580
1080230005727	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230005728	ATP binding site [chemical binding]; other site
1080230005729	putative Mg++ binding site [ion binding]; other site
1080230005730	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005731	YtxH-like protein; Region: YtxH; cl02079
1080230005732	CHASE domain; Region: CHASE; cl01369
1080230005733	PAS domain S-box; Region: sensory_box; TIGR00229
1080230005734	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230005735	putative active site [active]
1080230005736	heme pocket [chemical binding]; other site
1080230005737	GAF domain; Region: GAF_2; pfam13185
1080230005738	GAF domain; Region: GAF; cl15785
1080230005739	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230005740	PAS fold; Region: PAS_3; pfam08447
1080230005741	putative active site [active]
1080230005742	heme pocket [chemical binding]; other site
1080230005743	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230005744	metal binding site [ion binding]; metal-binding site
1080230005745	active site
1080230005746	I-site; other site
1080230005747	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230005748	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1080230005749	dinuclear metal binding motif [ion binding]; other site
1080230005750	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1080230005751	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1080230005752	iron-sulfur cluster [ion binding]; other site
1080230005753	[2Fe-2S] cluster binding site [ion binding]; other site
1080230005754	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1080230005755	The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506
1080230005756	putative di-iron ligands [ion binding]; other site
1080230005757	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1080230005758	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005759	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230005760	Membrane protein of unknown function; Region: DUF360; cl00850
1080230005761	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1080230005762	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1080230005763	Domain of unknown function DUF21; Region: DUF21; pfam01595
1080230005764	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1080230005765	Transporter associated domain; Region: CorC_HlyC; cl08393
1080230005766	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
1080230005767	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1080230005768	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
1080230005769	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
1080230005770	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
1080230005771	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1080230005772	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230005773	Cytochrome c; Region: Cytochrom_C; cl11414
1080230005774	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1080230005775	putative active site [active]
1080230005776	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1080230005777	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
1080230005778	glycine dehydrogenase; Provisional; Region: PRK05367
1080230005779	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1080230005780	tetramer interface [polypeptide binding]; other site
1080230005781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230005782	catalytic residue [active]
1080230005783	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1080230005784	tetramer interface [polypeptide binding]; other site
1080230005785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230005786	catalytic residue [active]
1080230005787	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1080230005788	active site
1080230005789	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1080230005790	Phosphoglycerate kinase; Region: PGK; pfam00162
1080230005791	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1080230005792	substrate binding site [chemical binding]; other site
1080230005793	hinge regions; other site
1080230005794	ADP binding site [chemical binding]; other site
1080230005795	catalytic site [active]
1080230005796	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1080230005797	Helix-turn-helix domains; Region: HTH; cl00088
1080230005798	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1080230005799	dimerization interface [polypeptide binding]; other site
1080230005800	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1080230005801	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
1080230005802	motif 1; other site
1080230005803	active site
1080230005804	motif 2; other site
1080230005805	motif 3; other site
1080230005806	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1080230005807	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
1080230005808	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
1080230005809	Ycf39; Provisional; Region: ycf39; CHL00194
1080230005810	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1080230005811	NAD(P) binding site [chemical binding]; other site
1080230005812	putative active site [active]
1080230005813	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
1080230005814	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
1080230005815	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230005816	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1080230005817	active site
1080230005818	dimerization interface [polypeptide binding]; other site
1080230005819	Nitrogen regulatory protein P-II; Region: P-II; cl00412
1080230005820	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1080230005821	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
1080230005822	Protein of unknown function (DUF1517); Region: DUF1517; cl01807
1080230005823	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
1080230005824	active site
1080230005825	EamA-like transporter family; Region: EamA; cl01037
1080230005826	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1080230005827	EamA-like transporter family; Region: EamA; cl01037
1080230005828	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
1080230005829	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1080230005830	active site
1080230005831	substrate binding pocket [chemical binding]; other site
1080230005832	dimer interface [polypeptide binding]; other site
1080230005833	hypothetical protein; Provisional; Region: PRK08317
1080230005834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230005835	S-adenosylmethionine binding site [chemical binding]; other site
1080230005836	cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059
1080230005837	cyanobacterial long protein repeat; Region: swm_rep_I; TIGR02059
1080230005838	Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cl00102
1080230005839	FG-GAP repeat; Region: FG-GAP; cl15299
1080230005840	Family description; Region: VCBS; pfam13517
1080230005841	Family description; Region: VCBS; pfam13517
1080230005842	Family description; Region: VCBS; pfam13517
1080230005843	FG-GAP repeat; Region: FG-GAP; cl15299
1080230005844	FG-GAP repeat; Region: FG-GAP; cl15299
1080230005845	Calx-beta domain; Region: Calx-beta; cl02522
1080230005846	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1080230005847	Protein of unknown function (DUF1275); Region: DUF1275; cl01453
1080230005848	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1080230005849	structural tetrad; other site
1080230005850	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1080230005851	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1080230005852	structural tetrad; other site
1080230005853	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
1080230005854	Heme NO binding; Region: HNOB; cl15268
1080230005855	ProP expression regulator; Provisional; Region: PRK04950
1080230005856	Predicted hydrocarbon binding protein (contains V4R domain) [General function prediction only]; Region: COG1719
1080230005857	Heme NO binding; Region: HNOB; cl15268
1080230005858	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230005859	catalytic loop [active]
1080230005860	iron binding site [ion binding]; other site
1080230005861	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1080230005862	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230005863	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230005864	catalytic loop [active]
1080230005865	iron binding site [ion binding]; other site
1080230005866	TPR repeat; Region: TPR_11; pfam13414
1080230005867	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1080230005868	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1080230005869	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1080230005870	active site
1080230005871	ATP binding site [chemical binding]; other site
1080230005872	substrate binding site [chemical binding]; other site
1080230005873	activation loop (A-loop); other site
1080230005874	Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042
1080230005875	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1080230005876	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1080230005877	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1080230005878	TM-ABC transporter signature motif; other site
1080230005879	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1080230005880	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
1080230005881	hinge region; other site
1080230005882	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1080230005883	putative nucleotide binding site [chemical binding]; other site
1080230005884	uridine monophosphate binding site [chemical binding]; other site
1080230005885	homohexameric interface [polypeptide binding]; other site
1080230005886	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230005887	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1080230005888	Clp amino terminal domain; Region: Clp_N; pfam02861
1080230005889	Clp amino terminal domain; Region: Clp_N; pfam02861
1080230005890	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230005891	Walker A motif; other site
1080230005892	ATP binding site [chemical binding]; other site
1080230005893	Walker B motif; other site
1080230005894	arginine finger; other site
1080230005895	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230005896	Walker A motif; other site
1080230005897	ATP binding site [chemical binding]; other site
1080230005898	Walker B motif; other site
1080230005899	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1080230005900	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1080230005901	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1080230005902	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1080230005903	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230005904	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
1080230005905	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230005906	Walker A motif; other site
1080230005907	ATP binding site [chemical binding]; other site
1080230005908	Walker B motif; other site
1080230005909	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1080230005910	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
1080230005911	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
1080230005912	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
1080230005913	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1080230005914	oligomer interface [polypeptide binding]; other site
1080230005915	active site residues [active]
1080230005916	Clp protease; Region: CLP_protease; pfam00574
1080230005917	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1080230005918	oligomer interface [polypeptide binding]; other site
1080230005919	active site residues [active]
1080230005920	proline aminopeptidase P II; Provisional; Region: PRK10879
1080230005921	Aminopeptidase P, N-terminal domain; Region: AMP_N; cl08433
1080230005922	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
1080230005923	active site
1080230005924	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
1080230005925	Protein of unknown function (DUF3134); Region: DUF3134; pfam11332
1080230005926	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
1080230005927	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230005928	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230005929	Coenzyme F420-reducing hydrogenase, beta subunit [Energy production and conversion]; Region: FrhB; COG1035
1080230005930	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
1080230005931	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
1080230005932	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1080230005933	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230005934	CobD/Cbib protein; Region: CobD_Cbib; cl00561
1080230005935	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1080230005936	RF-1 domain; Region: RF-1; cl02875
1080230005937	RF-1 domain; Region: RF-1; cl02875
1080230005938	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1080230005939	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
1080230005940	Cl- selectivity filter; other site
1080230005941	Cl- binding residues [ion binding]; other site
1080230005942	pore gating glutamate residue; other site
1080230005943	dimer interface [polypeptide binding]; other site
1080230005944	H+/Cl- coupling transport residue; other site
1080230005945	FOG: CBS domain [General function prediction only]; Region: COG0517
1080230005946	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612
1080230005947	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
1080230005948	Ligand Binding Site [chemical binding]; other site
1080230005949	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1080230005950	Ligand Binding Site [chemical binding]; other site
1080230005951	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1080230005952	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1080230005953	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1080230005954	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1080230005955	Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795
1080230005956	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230005957	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230005958	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230005959	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230005960	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230005961	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230005962	Cupin domain; Region: Cupin_2; cl09118
1080230005963	pyruvate dehydrogenase E1 component alpha subunit; Reviewed; Region: odpA; CHL00149
1080230005964	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1080230005965	tetramer interface [polypeptide binding]; other site
1080230005966	TPP-binding site [chemical binding]; other site
1080230005967	heterodimer interface [polypeptide binding]; other site
1080230005968	phosphorylation loop region [posttranslational modification]
1080230005969	H+ Antiporter protein; Region: 2A0121; TIGR00900
1080230005970	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230005971	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1080230005972	putative catalytic site [active]
1080230005973	putative phosphate binding site [ion binding]; other site
1080230005974	active site
1080230005975	metal binding site A [ion binding]; metal-binding site
1080230005976	DNA binding site [nucleotide binding]
1080230005977	putative AP binding site [nucleotide binding]; other site
1080230005978	putative metal binding site B [ion binding]; other site
1080230005979	Protein of unknown function (DUF3750); Region: DUF3750; pfam12570
1080230005980	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1080230005981	active site
1080230005982	multimer interface [polypeptide binding]; other site
1080230005983	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230005984	Helix-turn-helix domains; Region: HTH; cl00088
1080230005985	Integrase core domain; Region: rve; cl01316
1080230005986	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1080230005987	[2Fe-2S] cluster binding site [ion binding]; other site
1080230005988	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1080230005989	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
1080230005990	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1080230005991	putative acyl-acceptor binding pocket; other site
1080230005992	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1080230005993	Peptidase family M48; Region: Peptidase_M48; cl12018
1080230005994	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
1080230005995	TspO/MBR family; Region: TspO_MBR; cl01379
1080230005996	circadian clock protein KaiC; Reviewed; Region: PRK09302
1080230005997	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
1080230005998	Walker A motif; other site
1080230005999	ATP binding site [chemical binding]; other site
1080230006000	Walker B motif; other site
1080230006001	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230006002	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230006003	Walker A motif; other site
1080230006004	ATP binding site [chemical binding]; other site
1080230006005	Walker B motif; other site
1080230006006	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
1080230006007	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1080230006008	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1080230006009	Ligand binding site; other site
1080230006010	Putative Catalytic site; other site
1080230006011	DXD motif; other site
1080230006012	Alpha/beta hydrolase of unknown function (DUF1400); Region: DUF1400; pfam07176
1080230006013	Predicted dienelactone hydrolase [General function prediction only]; Region: COG4188
1080230006014	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1080230006015	Sulfatase; Region: Sulfatase; cl10460
1080230006016	Preprotein translocase SecG subunit; Region: SecG; cl09123
1080230006017	Predicted Zn-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: COG5549
1080230006018	Zinc-dependent metalloprotease; MMP_like sub-family 1. A group of bacterial, archaeal, and fungal metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_1; cd04279
1080230006019	active site
1080230006020	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1080230006021	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1080230006022	E3 interaction surface; other site
1080230006023	lipoyl attachment site [posttranslational modification]; other site
1080230006024	e3 binding domain; Region: E3_binding; pfam02817
1080230006025	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
1080230006026	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
1080230006027	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1080230006028	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1080230006029	metal-binding site [ion binding]
1080230006030	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230006031	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230006032	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230006033	phosphopeptide binding site; other site
1080230006034	Transcriptional regulator; Region: Transcrip_reg; cl00361
1080230006035	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1080230006036	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1080230006037	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1080230006038	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003
1080230006039	large tegument protein UL36; Provisional; Region: PHA03247
1080230006040	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1080230006041	Peptidase family M23; Region: Peptidase_M23; pfam01551
1080230006042	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
1080230006043	30S subunit binding site; other site
1080230006044	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
1080230006045	glycogen synthase; Provisional; Region: glgA; PRK00654
1080230006046	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1080230006047	ADP-binding pocket [chemical binding]; other site
1080230006048	homodimer interface [polypeptide binding]; other site
1080230006049	Domain of unknown function (DUF1830); Region: DUF1830; pfam08865
1080230006050	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1080230006051	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1080230006052	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230006053	FeS/SAM binding site; other site
1080230006054	RNA polymerase sigma factor; Validated; Region: PRK05949
1080230006055	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1080230006056	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230006057	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1080230006058	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230006059	DNA binding residues [nucleotide binding]
1080230006060	GTPase Era; Reviewed; Region: era; PRK00089
1080230006061	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1080230006062	G1 box; other site
1080230006063	GTP/Mg2+ binding site [chemical binding]; other site
1080230006064	Switch I region; other site
1080230006065	G2 box; other site
1080230006066	Switch II region; other site
1080230006067	G3 box; other site
1080230006068	G4 box; other site
1080230006069	G5 box; other site
1080230006070	KH-II  (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins  (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098
1080230006071	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1080230006072	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1080230006073	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230006074	ATP binding site [chemical binding]; other site
1080230006075	Mg2+ binding site [ion binding]; other site
1080230006076	G-X-G motif; other site
1080230006077	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1080230006078	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230006079	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230006080	active site
1080230006081	phosphorylation site [posttranslational modification]
1080230006082	intermolecular recognition site; other site
1080230006083	dimerization interface [polypeptide binding]; other site
1080230006084	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230006085	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230006086	active site
1080230006087	phosphorylation site [posttranslational modification]
1080230006088	intermolecular recognition site; other site
1080230006089	dimerization interface [polypeptide binding]; other site
1080230006090	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1080230006091	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
1080230006092	active site
1080230006093	catalytic site [active]
1080230006094	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
1080230006095	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230006096	dimer interface [polypeptide binding]; other site
1080230006097	conserved gate region; other site
1080230006098	putative PBP binding loops; other site
1080230006099	ABC-ATPase subunit interface; other site
1080230006100	MEKHLA domain; Region: MEKHLA; pfam08670
1080230006101	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230006102	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230006103	riboflavin synthase, alpha subunit; Region: ribE; TIGR00187
1080230006104	Lumazine binding domain; Region: Lum_binding; pfam00677
1080230006105	Lumazine binding domain; Region: Lum_binding; pfam00677
1080230006106	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1080230006107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230006108	dimer interface [polypeptide binding]; other site
1080230006109	conserved gate region; other site
1080230006110	putative PBP binding loops; other site
1080230006111	ABC-ATPase subunit interface; other site
1080230006112	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230006113	dimer interface [polypeptide binding]; other site
1080230006114	conserved gate region; other site
1080230006115	putative PBP binding loops; other site
1080230006116	ABC-ATPase subunit interface; other site
1080230006117	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1080230006118	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
1080230006119	active site
1080230006120	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1080230006121	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
1080230006122	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
1080230006123	YacP-like NYN domain; Region: NYN_YacP; cl01491
1080230006124	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230006125	putative active site [active]
1080230006126	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230006127	DNA binding residues [nucleotide binding]
1080230006128	dimerization interface [polypeptide binding]; other site
1080230006129	photosystem I subunit VII; Region: psaC; CHL00065
1080230006130	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1080230006131	NAD(P)H-quinone oxidoreductase subunit 4; Provisional; Region: PRK02546
1080230006132	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230006133	Bacterial SH3 domain; Region: SH3_3; cl02551
1080230006134	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1080230006135	phycobillisome linker protein; Region: apcE; CHL00091
1080230006136	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230006137	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1080230006138	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1080230006139	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1080230006140	Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449
1080230006141	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1080230006142	N-terminal catalytic domain of thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU; cd10796
1080230006143	putative active site [active]
1080230006144	catalytic site [active]
1080230006145	NurA domain; Region: NurA; cl09134
1080230006146	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1080230006147	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006148	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 1; Region: BMC_like_1_repeat1; cd07051
1080230006149	putative hexamer interface [polypeptide binding]; other site
1080230006150	putative hexagonal pore; other site
1080230006151	Bacterial Micro-Compartment (BMC)-like domain 1 repeat 2; Region: BMC_like_1_repeat2; cd07052
1080230006152	putative hexamer interface [polypeptide binding]; other site
1080230006153	putative hexagonal pore; other site
1080230006154	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230006155	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230006156	binding surface
1080230006157	TPR motif; other site
1080230006158	TPR repeat; Region: TPR_11; pfam13414
1080230006159	FOG: CBS domain [General function prediction only]; Region: COG0517
1080230006160	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1080230006161	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1080230006162	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1080230006163	catalytic residues [active]
1080230006164	Recombinase; Region: Recombinase; pfam07508
1080230006165	Uncharacterized family 1; belongs to a superfamily containing the transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_1; cd10158
1080230006166	putative homodimer interface [polypeptide binding]; other site
1080230006167	putative homotetramer interface [polypeptide binding]; other site
1080230006168	putative metal binding site [ion binding]; other site
1080230006169	putative homodimer-homodimer interface [polypeptide binding]; other site
1080230006170	putative allosteric switch controlling residues; other site
1080230006171	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1080230006172	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006173	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1080230006174	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230006175	substrate binding pocket [chemical binding]; other site
1080230006176	membrane-bound complex binding site; other site
1080230006177	hinge residues; other site
1080230006178	Streptogramin lyase [Defense mechanisms]; Region: Vgb; COG4257
1080230006179	glycine cleavage system T protein; Region: gcvT; TIGR00528
1080230006180	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1080230006181	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1080230006182	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1080230006183	HSP70 interaction site [polypeptide binding]; other site
1080230006184	Protein of unknown function (DUF4101); Region: DUF4101; pfam13355
1080230006185	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
1080230006186	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
1080230006187	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1080230006188	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1080230006189	active site
1080230006190	tetratricopeptide repeat protein; Provisional; Region: PRK11788
1080230006191	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1080230006192	structural tetrad; other site
1080230006193	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1080230006194	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1080230006195	structural tetrad; other site
1080230006196	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1080230006197	structural tetrad; other site
1080230006198	Predicted GTPases (dynamin-related) [General function prediction only]; Region: COG0699
1080230006199	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230006200	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230006201	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230006202	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230006203	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230006204	Recombination protein O N terminal; Region: RecO_N; cl15812
1080230006205	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1080230006206	Recombination protein O C terminal; Region: RecO_C; pfam02565
1080230006207	glycogen branching enzyme; Provisional; Region: PRK05402
1080230006208	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1080230006209	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1080230006210	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1080230006211	active site
1080230006212	catalytic site [active]
1080230006213	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
1080230006214	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230006215	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1080230006216	active site
1080230006217	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1080230006218	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
1080230006219	phosphate binding site [ion binding]; other site
1080230006220	putative substrate binding pocket [chemical binding]; other site
1080230006221	dimer interface [polypeptide binding]; other site
1080230006222	2-isopropylmalate synthase; Validated; Region: PRK00915
1080230006223	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1080230006224	active site
1080230006225	catalytic residues [active]
1080230006226	metal binding site [ion binding]; metal-binding site
1080230006227	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
1080230006228	GAF domain; Region: GAF_2; pfam13185
1080230006229	GAF domain; Region: GAF; cl15785
1080230006230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230006231	PAS domain; Region: PAS_9; pfam13426
1080230006232	putative active site [active]
1080230006233	heme pocket [chemical binding]; other site
1080230006234	PAS domain S-box; Region: sensory_box; TIGR00229
1080230006235	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230006236	PAS domain S-box; Region: sensory_box; TIGR00229
1080230006237	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230006238	putative active site [active]
1080230006239	heme pocket [chemical binding]; other site
1080230006240	PAS fold; Region: PAS_3; pfam08447
1080230006241	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1080230006242	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230006243	metal binding site [ion binding]; metal-binding site
1080230006244	active site
1080230006245	I-site; other site
1080230006246	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230006247	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1080230006248	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1080230006249	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1080230006250	RNA binding surface [nucleotide binding]; other site
1080230006251	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1080230006252	active site
1080230006253	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1080230006254	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230006255	OstA-like protein; Region: OstA; cl00844
1080230006256	Protein of unknown function (DUF3769); Region: DUF3769; pfam12600
1080230006257	Photosystem II reaction centre I protein (PSII 4.8 kDa protein); Region: PsbI; cl03640
1080230006258	Protein of unknown function (DUF721); Region: DUF721; cl02324
1080230006259	Domain of unknown function (DUF4347); Region: DUF4347; pfam14252
1080230006260	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006261	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006262	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006263	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006264	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006265	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006266	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006267	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006268	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006269	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006270	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006271	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006272	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006273	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006274	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006275	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006276	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006277	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006278	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006279	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006280	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006281	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006282	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006283	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006284	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006285	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1080230006286	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006287	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1080230006288	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1080230006289	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1080230006290	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1080230006291	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1080230006292	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
1080230006293	Protein export membrane protein; Region: SecD_SecF; cl14618
1080230006294	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1080230006295	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1080230006296	NAD(P) binding site [chemical binding]; other site
1080230006297	catalytic residues [active]
1080230006298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230006299	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1080230006300	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230006301	dimer interface [polypeptide binding]; other site
1080230006302	phosphorylation site [posttranslational modification]
1080230006303	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230006304	ATP binding site [chemical binding]; other site
1080230006305	Mg2+ binding site [ion binding]; other site
1080230006306	G-X-G motif; other site
1080230006307	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1080230006308	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
1080230006309	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1080230006310	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; pfam04174
1080230006311	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230006312	D-loop; other site
1080230006313	H-loop/switch region; other site
1080230006314	Ycf46; Provisional; Region: ycf46; CHL00195
1080230006315	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230006316	Walker A motif; other site
1080230006317	ATP binding site [chemical binding]; other site
1080230006318	Walker B motif; other site
1080230006319	arginine finger; other site
1080230006320	Protein of unknown function (DUF1257); Region: DUF1257; cl06088
1080230006321	Penicillin amidase; Region: Penicil_amidase; pfam01804
1080230006322	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1080230006323	Cephalosporin acylase (CA) belongs to a family of beta-lactam acylases that includes penicillin G acylase (PGA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_CA; cd01936
1080230006324	active site
1080230006325	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1080230006326	thymidylate kinase; Region: DTMP_kinase; TIGR00041
1080230006327	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1080230006328	TMP-binding site; other site
1080230006329	ATP-binding site [chemical binding]; other site
1080230006330	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1080230006331	CHAT domain; Region: CHAT; pfam12770
1080230006332	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1080230006333	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1080230006334	dimer interface [polypeptide binding]; other site
1080230006335	active site
1080230006336	metal binding site [ion binding]; metal-binding site
1080230006337	glutathione binding site [chemical binding]; other site
1080230006338	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1080230006339	classical (c) SDRs; Region: SDR_c; cd05233
1080230006340	NAD(P) binding site [chemical binding]; other site
1080230006341	active site
1080230006342	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230006343	S-adenosylmethionine binding site [chemical binding]; other site
1080230006344	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1080230006345	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1080230006346	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006347	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1080230006348	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1080230006349	Protein of unknown function DUF91; Region: DUF91; cl00709
1080230006350	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1080230006351	active site
1080230006352	oxyanion hole [active]
1080230006353	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1080230006354	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
1080230006355	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1080230006356	catalytic residue [active]
1080230006357	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1080230006358	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
1080230006359	Protein of unknown function (DUF433); Region: DUF433; cl01030
1080230006360	Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136
1080230006361	photochlorophyllide reductase subunit B; Region: chlB; CHL00076
1080230006362	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
1080230006363	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
1080230006364	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1080230006365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006366	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
1080230006367	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230006368	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1080230006369	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230006370	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230006371	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1080230006372	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1080230006373	Protein export membrane protein; Region: SecD_SecF; cl14618
1080230006374	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1080230006375	Protein export membrane protein; Region: SecD_SecF; cl14618
1080230006376	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1080230006377	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1080230006378	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1080230006379	trimer interface [polypeptide binding]; other site
1080230006380	active site
1080230006381	UDP-GlcNAc binding site [chemical binding]; other site
1080230006382	lipid binding site [chemical binding]; lipid-binding site
1080230006383	ribosomal protein L20; Region: rpl20; CHL00068
1080230006384	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1080230006385	23S rRNA binding site [nucleotide binding]; other site
1080230006386	L21 binding site [polypeptide binding]; other site
1080230006387	L13 binding site [polypeptide binding]; other site
1080230006388	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
1080230006389	DNA repair protein radc; Region: radc; TIGR00608
1080230006390	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1080230006391	MPN+ (JAMM) motif; other site
1080230006392	Zinc-binding site [ion binding]; other site
1080230006393	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1080230006394	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1080230006395	active site residue [active]
1080230006396	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1080230006397	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
1080230006398	Walker A/P-loop; other site
1080230006399	ATP binding site [chemical binding]; other site
1080230006400	Q-loop/lid; other site
1080230006401	ABC transporter signature motif; other site
1080230006402	Walker B; other site
1080230006403	D-loop; other site
1080230006404	H-loop/switch region; other site
1080230006405	tellurium resistance terB-like protein; Region: terB_like; cd07177
1080230006406	metal binding site [ion binding]; metal-binding site
1080230006407	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
1080230006408	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1080230006409	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230006410	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
1080230006411	Walker A/P-loop; other site
1080230006412	ATP binding site [chemical binding]; other site
1080230006413	Q-loop/lid; other site
1080230006414	ABC transporter signature motif; other site
1080230006415	Walker B; other site
1080230006416	D-loop; other site
1080230006417	H-loop/switch region; other site
1080230006418	amidophosphoribosyltransferase; Provisional; Region: PRK07349
1080230006419	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1080230006420	active site
1080230006421	tetramer interface [polypeptide binding]; other site
1080230006422	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1080230006423	active site
1080230006424	Photosystem II reaction centre T protein; Region: PsbT; cl11601
1080230006425	transcriptional regulator NrdR; Region: TIGR00244
1080230006426	ATP cone domain; Region: ATP-cone; pfam03477
1080230006427	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1080230006428	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1080230006429	dimer interface [polypeptide binding]; other site
1080230006430	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1080230006431	catalytic triad [active]
1080230006432	peroxidatic and resolving cysteines [active]
1080230006433	Ribosome-binding factor A; Region: RBFA; cl00542
1080230006434	Protein of unknown function (DUF751); Region: DUF751; pfam05421
1080230006435	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1080230006436	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14186
1080230006437	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1080230006438	homodimer interface [polypeptide binding]; other site
1080230006439	NADP binding site [chemical binding]; other site
1080230006440	substrate binding site [chemical binding]; other site
1080230006441	Substrate binding subunit of ER-derived-lipid transporter; Provisional; Region: PLN03094
1080230006442	mce related protein; Region: MCE; pfam02470
1080230006443	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
1080230006444	Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231
1080230006445	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006446	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006447	adaptive-response sensory kinase; Validated; Region: PRK09303
1080230006448	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
1080230006449	tetramer interface [polypeptide binding]; other site
1080230006450	dimer interface [polypeptide binding]; other site
1080230006451	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230006452	dimer interface [polypeptide binding]; other site
1080230006453	phosphorylation site [posttranslational modification]
1080230006454	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230006455	ATP binding site [chemical binding]; other site
1080230006456	Mg2+ binding site [ion binding]; other site
1080230006457	G-X-G motif; other site
1080230006458	Sporulation and spore germination; Region: Germane; cl11253
1080230006459	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1080230006460	substrate binding site [chemical binding]; other site
1080230006461	dimer interface [polypeptide binding]; other site
1080230006462	catalytic triad [active]
1080230006463	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1080230006464	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
1080230006465	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1080230006466	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230006467	substrate binding pocket [chemical binding]; other site
1080230006468	membrane-bound complex binding site; other site
1080230006469	hinge residues; other site
1080230006470	Bacterial Ig-like domain; Region: Big_5; cl01012
1080230006471	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1080230006472	Qi binding site; other site
1080230006473	intrachain domain interface; other site
1080230006474	interchain domain interface [polypeptide binding]; other site
1080230006475	heme bH binding site [chemical binding]; other site
1080230006476	heme bL binding site [chemical binding]; other site
1080230006477	Qo binding site; other site
1080230006478	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
1080230006479	interchain domain interface [polypeptide binding]; other site
1080230006480	intrachain domain interface; other site
1080230006481	Qi binding site; other site
1080230006482	Qo binding site; other site
1080230006483	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1080230006484	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1080230006485	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1080230006486	dimerization interface [polypeptide binding]; other site
1080230006487	active site
1080230006488	metal binding site [ion binding]; metal-binding site
1080230006489	Acylphosphatase; Region: Acylphosphatase; cl00551
1080230006490	[NiFe] hydrogenase maturation protein HypF; Region: hypF; TIGR00143
1080230006491	HypF finger; Region: zf-HYPF; pfam07503
1080230006492	HypF finger; Region: zf-HYPF; pfam07503
1080230006493	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1080230006494	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1080230006495	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1080230006496	catalytic site [active]
1080230006497	putative active site [active]
1080230006498	putative substrate binding site [chemical binding]; other site
1080230006499	Protein of unknown function (DUF3747); Region: DUF3747; pfam12565
1080230006500	LytB protein; Region: LYTB; cl00507
1080230006501	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
1080230006502	Protein of unknown function (DUF3318); Region: DUF3318; pfam11780
1080230006503	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230006504	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230006505	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230006506	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1080230006507	Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636
1080230006508	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230006509	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230006510	Helix-turn-helix domains; Region: HTH; cl00088
1080230006511	Integrase core domain; Region: rve; cl01316
1080230006512	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230006513	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1080230006514	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1080230006515	TPR motif; other site
1080230006516	binding surface
1080230006517	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1080230006518	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
1080230006519	Walker A/P-loop; other site
1080230006520	ATP binding site [chemical binding]; other site
1080230006521	Q-loop/lid; other site
1080230006522	ABC transporter signature motif; other site
1080230006523	Walker B; other site
1080230006524	D-loop; other site
1080230006525	H-loop/switch region; other site
1080230006526	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
1080230006527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006528	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1080230006529	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1080230006530	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230006531	dimer interface [polypeptide binding]; other site
1080230006532	conserved gate region; other site
1080230006533	putative PBP binding loops; other site
1080230006534	ABC-ATPase subunit interface; other site
1080230006535	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1080230006536	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
1080230006537	dimer interface [polypeptide binding]; other site
1080230006538	motif 1; other site
1080230006539	active site
1080230006540	motif 2; other site
1080230006541	motif 3; other site
1080230006542	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1080230006543	anticodon binding site; other site
1080230006544	Ring-infected erythrocyte surface antigen; Provisional; Region: PTZ00341
1080230006545	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230006546	Coenzyme A binding pocket [chemical binding]; other site
1080230006547	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1080230006548	dinuclear metal binding motif [ion binding]; other site
1080230006549	Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl00503
1080230006550	Protein of unknown function (DUF1190); Region: DUF1190; cl10031
1080230006551	Flavin Reductases; Region: FlaRed; cl00801
1080230006552	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
1080230006553	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1080230006554	active site
1080230006555	metal binding site [ion binding]; metal-binding site
1080230006556	DNA binding site [nucleotide binding]
1080230006557	Clp protease ATP binding subunit; Region: clpC; CHL00095
1080230006558	Clp amino terminal domain; Region: Clp_N; pfam02861
1080230006559	Clp amino terminal domain; Region: Clp_N; pfam02861
1080230006560	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230006561	Walker A motif; other site
1080230006562	ATP binding site [chemical binding]; other site
1080230006563	Walker B motif; other site
1080230006564	arginine finger; other site
1080230006565	UvrB/uvrC motif; Region: UVR; pfam02151
1080230006566	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230006567	Walker A motif; other site
1080230006568	ATP binding site [chemical binding]; other site
1080230006569	Walker B motif; other site
1080230006570	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1080230006571	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1080230006572	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1080230006573	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1080230006574	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1080230006575	hypothetical protein; Provisional; Region: PRK08185
1080230006576	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1080230006577	intersubunit interface [polypeptide binding]; other site
1080230006578	active site
1080230006579	zinc binding site [ion binding]; other site
1080230006580	Na+ binding site [ion binding]; other site
1080230006581	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1080230006582	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1080230006583	inhibitor-cofactor binding pocket; inhibition site
1080230006584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230006585	catalytic residue [active]
1080230006586	Membrane-bound lytic murein transglycosylase [Cell envelope biogenesis, outer membrane]; Region: MltA; COG2821
1080230006587	MltA specific insert domain; Region: MltA; cl08398
1080230006588	3D domain; Region: 3D; cl01439
1080230006589	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1080230006590	WcbM_like is a subfamily of nucleotidyl transferases; Region: NTP_transferase_WcbM_like; cd06915
1080230006591	Substrate binding site; other site
1080230006592	Mg++ binding site; other site
1080230006593	metal-binding site
1080230006594	Mg++ binding site; other site
1080230006595	metal-binding site
1080230006596	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1080230006597	C-terminal peptidase (prc); Region: prc; TIGR00225
1080230006598	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1080230006599	protein binding site [polypeptide binding]; other site
1080230006600	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1080230006601	Catalytic dyad [active]
1080230006602	ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit; Region: rbcL; CHL00040
1080230006603	Ribulose bisphosphate carboxylase large chain, Form I; Region: RuBisCO_large_I; cd08212
1080230006604	homodimer interface [polypeptide binding]; other site
1080230006605	active site
1080230006606	heterodimer interface [polypeptide binding]; other site
1080230006607	catalytic residue [active]
1080230006608	metal binding site [ion binding]; metal-binding site
1080230006609	RbcX protein; Region: RcbX; pfam02341
1080230006610	Ribulose bisphosphate carboxylase/oxygenase (Rubisco), small subunit. Rubisco is a bifunctional enzyme catalyzes the initial steps of two opposing metabolic pathways: photosynthetic carbon fixation and the competing process of photorespiration. Rubisco...; Region: RuBisCO_small; cd03527
1080230006611	multimerization interface [polypeptide binding]; other site
1080230006612	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
1080230006613	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1080230006614	MgtC family; Region: MgtC; pfam02308
1080230006615	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230006616	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230006617	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230006618	lipid-A-disaccharide synthase; Region: lpxB; TIGR00215
1080230006619	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1080230006620	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230006621	catalytic loop [active]
1080230006622	iron binding site [ion binding]; other site
1080230006623	RDD family; Region: RDD; cl00746
1080230006624	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1080230006625	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1080230006626	hinge; other site
1080230006627	active site
1080230006628	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1080230006629	Class II fumarases; Region: Fumarase_classII; cd01362
1080230006630	active site
1080230006631	tetramer interface [polypeptide binding]; other site
1080230006632	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
1080230006633	P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188
1080230006634	Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577
1080230006635	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
1080230006636	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230006637	putative active site [active]
1080230006638	aspartate aminotransferase; Provisional; Region: PRK05942
1080230006639	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1080230006640	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230006641	homodimer interface [polypeptide binding]; other site
1080230006642	catalytic residue [active]
1080230006643	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1080230006644	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230006645	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1080230006646	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1080230006647	generic binding surface II; other site
1080230006648	ssDNA binding site; other site
1080230006649	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230006650	ATP binding site [chemical binding]; other site
1080230006651	putative Mg++ binding site [ion binding]; other site
1080230006652	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1080230006653	nucleotide binding region [chemical binding]; other site
1080230006654	ATP-binding site [chemical binding]; other site
1080230006655	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1080230006656	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1080230006657	tandem repeat interface [polypeptide binding]; other site
1080230006658	oligomer interface [polypeptide binding]; other site
1080230006659	active site residues [active]
1080230006660	Transglycosylase; Region: Transgly; cl07896
1080230006661	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1080230006662	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230006663	GMP synthase; Reviewed; Region: guaA; PRK00074
1080230006664	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1080230006665	AMP/PPi binding site [chemical binding]; other site
1080230006666	candidate oxyanion hole; other site
1080230006667	catalytic triad [active]
1080230006668	potential glutamine specificity residues [chemical binding]; other site
1080230006669	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1080230006670	ATP Binding subdomain [chemical binding]; other site
1080230006671	Ligand Binding sites [chemical binding]; other site
1080230006672	Dimerization subdomain; other site
1080230006673	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1080230006674	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230006675	cofactor binding site; other site
1080230006676	DNA binding site [nucleotide binding]
1080230006677	substrate interaction site [chemical binding]; other site
1080230006678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230006679	Bacitracin resistance protein BacA; Region: BacA; cl00858
1080230006680	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1080230006681	homotrimer interface [polypeptide binding]; other site
1080230006682	Walker A motif; other site
1080230006683	GTP binding site [chemical binding]; other site
1080230006684	Walker B motif; other site
1080230006685	acyl-ACP reductase; Provisional; Region: PRK14982
1080230006686	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006687	NAD(P) binding pocket [chemical binding]; other site
1080230006688	WAX2 C-terminal domain; Region: Wax2_C; pfam12076
1080230006689	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1080230006690	dinuclear metal binding motif [ion binding]; other site
1080230006691	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
1080230006692	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
1080230006693	substrate binding site; other site
1080230006694	metal-binding site
1080230006695	Oligomer interface; other site
1080230006696	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1080230006697	glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211
1080230006698	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1080230006699	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1080230006700	putative active site [active]
1080230006701	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
1080230006702	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1080230006703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006704	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230006705	active site
1080230006706	phosphorylation site [posttranslational modification]
1080230006707	intermolecular recognition site; other site
1080230006708	dimerization interface [polypeptide binding]; other site
1080230006709	PAS domain S-box; Region: sensory_box; TIGR00229
1080230006710	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230006711	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230006712	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1080230006713	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230006714	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1080230006715	PAS domain S-box; Region: sensory_box; TIGR00229
1080230006716	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230006717	putative active site [active]
1080230006718	heme pocket [chemical binding]; other site
1080230006719	PAS domain S-box; Region: sensory_box; TIGR00229
1080230006720	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230006721	putative active site [active]
1080230006722	heme pocket [chemical binding]; other site
1080230006723	PAS domain S-box; Region: sensory_box; TIGR00229
1080230006724	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230006725	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1080230006726	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230006727	dimer interface [polypeptide binding]; other site
1080230006728	phosphorylation site [posttranslational modification]
1080230006729	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230006730	ATP binding site [chemical binding]; other site
1080230006731	Mg2+ binding site [ion binding]; other site
1080230006732	G-X-G motif; other site
1080230006733	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1080230006734	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006735	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1080230006736	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1080230006737	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1080230006738	Integrase core domain; Region: rve; cl01316
1080230006739	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230006740	Helix-turn-helix domains; Region: HTH; cl00088
1080230006741	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
1080230006742	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230006743	putative active site [active]
1080230006744	cell division protein; Validated; Region: ftsH; CHL00176
1080230006745	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230006746	Walker A motif; other site
1080230006747	ATP binding site [chemical binding]; other site
1080230006748	Walker B motif; other site
1080230006749	arginine finger; other site
1080230006750	Peptidase family M41; Region: Peptidase_M41; pfam01434
1080230006751	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1080230006752	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
1080230006753	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1080230006754	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230006755	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230006756	Helix-turn-helix domains; Region: HTH; cl00088
1080230006757	Integrase core domain; Region: rve; cl01316
1080230006758	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1080230006759	helix-hairpin-helix signature motif; other site
1080230006760	substrate binding pocket [chemical binding]; other site
1080230006761	active site
1080230006762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4370
1080230006763	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1080230006764	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1080230006765	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1080230006766	catalytic residues [active]
1080230006767	Predicted proline hydroxylase [Posttranslational modification, protein turnover, chaperones]; Region: EGL-9; COG3751
1080230006768	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; cl15773
1080230006769	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1080230006770	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1080230006771	ring oligomerisation interface [polypeptide binding]; other site
1080230006772	ATP/Mg binding site [chemical binding]; other site
1080230006773	stacking interactions; other site
1080230006774	hinge regions; other site
1080230006775	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1080230006776	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
1080230006777	Walker A/P-loop; other site
1080230006778	ATP binding site [chemical binding]; other site
1080230006779	Q-loop/lid; other site
1080230006780	ABC transporter signature motif; other site
1080230006781	Walker B; other site
1080230006782	D-loop; other site
1080230006783	H-loop/switch region; other site
1080230006784	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230006785	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230006786	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230006787	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230006788	Protein of unknown function (DUF541); Region: SIMPL; cl01077
1080230006789	Domain of unknown function (DUF4335); Region: DUF4335; pfam14233
1080230006790	potential protein location (hypothetical protein) that overlaps protein (hypothetical protein)
1080230006791	Protein of unknown function (DUF3038); Region: DUF3038; pfam11237
1080230006792	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
1080230006793	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1080230006794	active site
1080230006795	O-succinylbenzoate synthase; Provisional; Region: PRK02714
1080230006796	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
1080230006797	active site
1080230006798	cyclophilin_TLP40_like: cyclophilin-type peptidylprolyl cis- trans isomerases (cyclophilins) similar ot the Spinach thylakoid lumen protein TLP40. Compared to the archetypal cyclophilin Human cyclophilin A, these proteins have similar peptidylprolyl...; Region: cyclophilin_TLP40_like; cd01924
1080230006799	active site
1080230006800	elongation factor P; Validated; Region: PRK00529
1080230006801	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1080230006802	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1080230006803	RNA binding site [nucleotide binding]; other site
1080230006804	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1080230006805	RNA binding site [nucleotide binding]; other site
1080230006806	acetyl-CoA carboxylase, biotin carboxyl carrier protein; Region: BCCP; TIGR00531
1080230006807	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1080230006808	carboxyltransferase (CT) interaction site; other site
1080230006809	biotinylation site [posttranslational modification]; other site
1080230006810	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
1080230006811	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1080230006812	Hexamer interface [polypeptide binding]; other site
1080230006813	Hexagonal pore residue; other site
1080230006814	Carbon dioxide concentrating mechanism (CcmK); Bacterial Micro-Compartment (BCM) domain; Region: BMC_CcmK; cd07057
1080230006815	Hexamer interface [polypeptide binding]; other site
1080230006816	Hexagonal pore residue; other site
1080230006817	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230006818	putative active site [active]
1080230006819	FAD binding domain; Region: FAD_binding_4; pfam01565
1080230006820	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1080230006821	Protein of unknown function (DUF3082); Region: DUF3082; pfam11282
1080230006822	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1080230006823	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1080230006824	structural tetrad; other site
1080230006825	Integrase core domain; Region: rve; cl01316
1080230006826	aspartate aminotransferase; Provisional; Region: PRK05764
1080230006827	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1080230006828	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230006829	homodimer interface [polypeptide binding]; other site
1080230006830	catalytic residue [active]
1080230006831	citrate synthase; Provisional; Region: PRK14036
1080230006832	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_1; cd06112
1080230006833	dimer interface [polypeptide binding]; other site
1080230006834	active site
1080230006835	citrylCoA binding site [chemical binding]; other site
1080230006836	oxalacetate/citrate binding site [chemical binding]; other site
1080230006837	coenzyme A binding site [chemical binding]; other site
1080230006838	catalytic triad [active]
1080230006839	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1080230006840	catalytic core [active]
1080230006841	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230006842	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1080230006843	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1080230006844	thiS-thiF/thiG interaction site; other site
1080230006845	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230006846	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
1080230006847	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075
1080230006848	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1080230006849	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230006850	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1080230006851	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1080230006852	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1080230006853	putative active site [active]
1080230006854	putative substrate binding site [chemical binding]; other site
1080230006855	putative cosubstrate binding site; other site
1080230006856	catalytic site [active]
1080230006857	carbonic anhydrase; Provisional; Region: PRK15219
1080230006858	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
1080230006859	active site clefts [active]
1080230006860	zinc binding site [ion binding]; other site
1080230006861	dimer interface [polypeptide binding]; other site
1080230006862	Predicted proteasome-type protease [Posttranslational modification, protein turnover, chaperones]; Region: COG3484
1080230006863	Bacterial proteasome, beta subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that...; Region: proteasome_beta_bacterial; cd03765
1080230006864	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1080230006865	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230006866	HEAT repeats; Region: HEAT_2; pfam13646
1080230006867	HEAT repeats; Region: HEAT_2; pfam13646
1080230006868	HEAT repeats; Region: HEAT_2; pfam13646
1080230006869	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1080230006870	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1080230006871	putative C-terminal domain interface [polypeptide binding]; other site
1080230006872	putative GSH binding site (G-site) [chemical binding]; other site
1080230006873	putative dimer interface [polypeptide binding]; other site
1080230006874	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1080230006875	N-terminal domain interface [polypeptide binding]; other site
1080230006876	substrate binding pocket (H-site) [chemical binding]; other site
1080230006877	acetohydroxyacid synthase small subunit; Region: ilvH; CHL00100
1080230006878	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1080230006879	putative valine binding site [chemical binding]; other site
1080230006880	dimer interface [polypeptide binding]; other site
1080230006881	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1080230006882	Protein of unknown function (DUF3285); Region: DUF3285; pfam11688
1080230006883	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
1080230006884	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
1080230006885	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1080230006886	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1080230006887	glutamine binding [chemical binding]; other site
1080230006888	catalytic triad [active]
1080230006889	UbiA prenyltransferase family; Region: UbiA; cl00337
1080230006890	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1080230006891	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1080230006892	substrate binding pocket [chemical binding]; other site
1080230006893	membrane-bound complex binding site; other site
1080230006894	hinge residues; other site
1080230006895	Protein of unknown function (DUF3539); Region: DUF3539; pfam12058
1080230006896	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1080230006897	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
1080230006898	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
1080230006899	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1080230006900	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1080230006901	active site
1080230006902	nucleophile elbow; other site
1080230006903	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1080230006904	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
1080230006905	molecular chaperone DnaK; Provisional; Region: PRK13411
1080230006906	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
1080230006907	MgATP binding site [chemical binding]; other site
1080230006908	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
1080230006909	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1080230006910	dimer interface [polypeptide binding]; other site
1080230006911	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1080230006912	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1080230006913	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1080230006914	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1080230006915	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1080230006916	Walker A motif; other site
1080230006917	ATP binding site [chemical binding]; other site
1080230006918	Walker B motif; other site
1080230006919	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1080230006920	THUMP domain; Region: THUMP; cl12076
1080230006921	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230006922	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230006923	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1080230006924	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1080230006925	catalytic motif [active]
1080230006926	Zn binding site [ion binding]; other site
1080230006927	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
1080230006928	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1080230006929	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1080230006930	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1080230006931	Domain of unknown function DUF59; Region: DUF59; cl00941
1080230006932	antiporter inner membrane protein; Provisional; Region: PRK11670
1080230006933	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1080230006934	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1080230006935	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1080230006936	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230006937	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
1080230006938	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1080230006939	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1080230006940	nucleoside/Zn binding site; other site
1080230006941	dimer interface [polypeptide binding]; other site
1080230006942	catalytic motif [active]
1080230006943	Domain of unknown function (DUF3404); Region: DUF3404; pfam11884
1080230006944	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1080230006945	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1080230006946	putative active site [active]
1080230006947	substrate binding site [chemical binding]; other site
1080230006948	putative cosubstrate binding site; other site
1080230006949	catalytic site [active]
1080230006950	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1080230006951	substrate binding site [chemical binding]; other site
1080230006952	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1080230006953	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
1080230006954	Walker A/P-loop; other site
1080230006955	ATP binding site [chemical binding]; other site
1080230006956	Q-loop/lid; other site
1080230006957	ABC transporter signature motif; other site
1080230006958	Walker B; other site
1080230006959	D-loop; other site
1080230006960	H-loop/switch region; other site
1080230006961	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
1080230006962	ribosomal protein S4; Reviewed; Region: rps4; CHL00113
1080230006963	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1080230006964	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1080230006965	RNA binding surface [nucleotide binding]; other site
1080230006966	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1080230006967	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1080230006968	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1080230006969	putative catalytic cysteine [active]
1080230006970	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1080230006971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230006972	GAF domain; Region: GAF; cl15785
1080230006973	Phytochrome region; Region: PHY; pfam00360
1080230006974	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230006975	dimer interface [polypeptide binding]; other site
1080230006976	phosphorylation site [posttranslational modification]
1080230006977	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230006978	ATP binding site [chemical binding]; other site
1080230006979	Mg2+ binding site [ion binding]; other site
1080230006980	G-X-G motif; other site
1080230006981	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230006982	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230006983	active site
1080230006984	phosphorylation site [posttranslational modification]
1080230006985	intermolecular recognition site; other site
1080230006986	dimerization interface [polypeptide binding]; other site
1080230006987	excinuclease ABC subunit B; Provisional; Region: PRK05298
1080230006988	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230006989	ATP binding site [chemical binding]; other site
1080230006990	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1080230006991	nucleotide binding region [chemical binding]; other site
1080230006992	ATP-binding site [chemical binding]; other site
1080230006993	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1080230006994	Photosystem II reaction centre X protein (PsbX); Region: PsbX; cl05887
1080230006995	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1080230006996	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1080230006997	active site
1080230006998	substrate binding site [chemical binding]; other site
1080230006999	cosubstrate binding site; other site
1080230007000	catalytic site [active]
1080230007001	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1080230007002	Ycf46; Provisional; Region: ycf46; CHL00195
1080230007003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230007004	Walker A motif; other site
1080230007005	ATP binding site [chemical binding]; other site
1080230007006	Walker B motif; other site
1080230007007	arginine finger; other site
1080230007008	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230007009	S-adenosylmethionine binding site [chemical binding]; other site
1080230007010	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007011	Domain of unknown function (DUF4308); Region: DUF4308; cl14566
1080230007012	Sensory domain found in DIguanylate Cyclases & Two-component systems; Region: DICT; cl01731
1080230007013	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230007014	GAF domain; Region: GAF; cl15785
1080230007015	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230007016	dimer interface [polypeptide binding]; other site
1080230007017	phosphorylation site [posttranslational modification]
1080230007018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230007019	ATP binding site [chemical binding]; other site
1080230007020	Mg2+ binding site [ion binding]; other site
1080230007021	G-X-G motif; other site
1080230007022	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230007023	PAS domain; Region: PAS_9; pfam13426
1080230007024	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1080230007025	integral membrane protein MviN; Region: mviN; TIGR01695
1080230007026	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1080230007027	putative active site pocket [active]
1080230007028	dimerization interface [polypeptide binding]; other site
1080230007029	putative catalytic residue [active]
1080230007030	O-succinylbenzoic acid--CoA ligase; Reviewed; Region: PRK07445
1080230007031	AMP-binding enzyme; Region: AMP-binding; cl15778
1080230007032	Cupin domain; Region: Cupin_2; cl09118
1080230007033	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1080230007034	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007035	NAD(P) binding site [chemical binding]; other site
1080230007036	active site
1080230007037	homoserine dehydrogenase; Provisional; Region: PRK06349
1080230007038	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007039	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1080230007040	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1080230007041	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1080230007042	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
1080230007043	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1080230007044	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1080230007045	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1080230007046	dimer interface [polypeptide binding]; other site
1080230007047	motif 1; other site
1080230007048	active site
1080230007049	motif 2; other site
1080230007050	motif 3; other site
1080230007051	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
1080230007052	oligomeric interface; other site
1080230007053	putative active site [active]
1080230007054	homodimer interface [polypeptide binding]; other site
1080230007055	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
1080230007056	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1080230007057	putative anti-sigmaE protein; Provisional; Region: PRK13920
1080230007058	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1080230007059	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230007060	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230007061	DNA binding residues [nucleotide binding]
1080230007062	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1080230007063	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
1080230007064	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1080230007065	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
1080230007066	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
1080230007067	Walker A/P-loop; other site
1080230007068	ATP binding site [chemical binding]; other site
1080230007069	Q-loop/lid; other site
1080230007070	ABC transporter signature motif; other site
1080230007071	Walker B; other site
1080230007072	D-loop; other site
1080230007073	H-loop/switch region; other site
1080230007074	phosphate transporter ATP-binding protein; Provisional; Region: PRK14243
1080230007075	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
1080230007076	Walker A/P-loop; other site
1080230007077	ATP binding site [chemical binding]; other site
1080230007078	Q-loop/lid; other site
1080230007079	ABC transporter signature motif; other site
1080230007080	Walker B; other site
1080230007081	D-loop; other site
1080230007082	H-loop/switch region; other site
1080230007083	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1080230007084	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230007085	dimer interface [polypeptide binding]; other site
1080230007086	conserved gate region; other site
1080230007087	putative PBP binding loops; other site
1080230007088	ABC-ATPase subunit interface; other site
1080230007089	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1080230007090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230007091	dimer interface [polypeptide binding]; other site
1080230007092	conserved gate region; other site
1080230007093	putative PBP binding loops; other site
1080230007094	ABC-ATPase subunit interface; other site
1080230007095	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230007096	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230007097	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230007098	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230007099	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230007100	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230007101	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
1080230007102	PspA/IM30 family; Region: PspA_IM30; pfam04012
1080230007103	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230007104	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12902
1080230007105	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007106	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
1080230007107	Predicted membrane protein [Function unknown]; Region: COG2119
1080230007108	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1080230007109	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1080230007110	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
1080230007111	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1080230007112	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230007113	Walker A motif; other site
1080230007114	ATP binding site [chemical binding]; other site
1080230007115	Walker B motif; other site
1080230007116	arginine finger; other site
1080230007117	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1080230007118	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1080230007119	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007120	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1080230007121	ThiS interaction site; other site
1080230007122	putative active site [active]
1080230007123	tetramer interface [polypeptide binding]; other site
1080230007124	Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354
1080230007125	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1080230007126	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
1080230007127	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1080230007128	dimer interface [polypeptide binding]; other site
1080230007129	motif 1; other site
1080230007130	active site
1080230007131	motif 2; other site
1080230007132	motif 3; other site
1080230007133	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1080230007134	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230007135	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230007136	dimer interface [polypeptide binding]; other site
1080230007137	phosphorylation site [posttranslational modification]
1080230007138	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230007139	ATP binding site [chemical binding]; other site
1080230007140	Mg2+ binding site [ion binding]; other site
1080230007141	G-X-G motif; other site
1080230007142	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
1080230007143	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
1080230007144	BT1 family; Region: BT1; pfam03092
1080230007145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230007146	putative substrate translocation pore; other site
1080230007147	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1080230007148	active site
1080230007149	putative substrate binding region [chemical binding]; other site
1080230007150	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1080230007151	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_9; cd06344
1080230007152	putative ligand binding site [chemical binding]; other site
1080230007153	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1080230007154	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1080230007155	FMN binding site [chemical binding]; other site
1080230007156	active site
1080230007157	catalytic residues [active]
1080230007158	substrate binding site [chemical binding]; other site
1080230007159	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
1080230007160	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
1080230007161	dimer interface [polypeptide binding]; other site
1080230007162	tetramer interface [polypeptide binding]; other site
1080230007163	PYR/PP interface [polypeptide binding]; other site
1080230007164	TPP binding site [chemical binding]; other site
1080230007165	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
1080230007166	TPP-binding site; other site
1080230007167	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1080230007168	active site
1080230007169	VWA ORF176 type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_ORF176_type; cd01457
1080230007170	metal ion-dependent adhesion site (MIDAS); other site
1080230007171	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230007172	D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4) [Cell envelope biogenesis, outer membrane]; Region: DacB; COG2027
1080230007173	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1080230007174	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1080230007175	putative active site [active]
1080230007176	catalytic triad [active]
1080230007177	dimer interface [polypeptide binding]; other site
1080230007178	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
1080230007179	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1080230007180	active site
1080230007181	HIGH motif; other site
1080230007182	KMSKS motif; other site
1080230007183	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1080230007184	anticodon binding site; other site
1080230007185	tRNA binding surface [nucleotide binding]; other site
1080230007186	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1080230007187	LabA_like proteins; Region: LabA; cd10911
1080230007188	putative metal binding site [ion binding]; other site
1080230007189	deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353
1080230007190	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1080230007191	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1080230007192	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1080230007193	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230007194	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230007195	active site
1080230007196	phosphorylation site [posttranslational modification]
1080230007197	intermolecular recognition site; other site
1080230007198	dimerization interface [polypeptide binding]; other site
1080230007199	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230007200	DNA binding site [nucleotide binding]
1080230007201	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1080230007202	catalytic core [active]
1080230007203	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1080230007204	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1080230007205	The C-terminal domain of a subfamily of Na+ /H+ antiporter existed in bacteria and archea . Na+/H+ exchange proteins eject protons from cells, effectively eliminating excess acid from actively metabolising cells. Na+ /H+ exchange activity is also crucial...; Region: Na_H_Antiporter_C; cd01988
1080230007206	Ligand Binding Site [chemical binding]; other site
1080230007207	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
1080230007208	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230007209	DNA gyrase subunit A; Validated; Region: PRK05560
1080230007210	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
1080230007211	CAP-like domain; other site
1080230007212	active site
1080230007213	primary dimer interface [polypeptide binding]; other site
1080230007214	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1080230007215	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1080230007216	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1080230007217	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1080230007218	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1080230007219	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1080230007220	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1080230007221	active site
1080230007222	metal binding site [ion binding]; metal-binding site
1080230007223	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1080230007224	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
1080230007225	Walker A/P-loop; other site
1080230007226	ATP binding site [chemical binding]; other site
1080230007227	Q-loop/lid; other site
1080230007228	ABC transporter signature motif; other site
1080230007229	Walker B; other site
1080230007230	D-loop; other site
1080230007231	H-loop/switch region; other site
1080230007232	Cobalt transport protein; Region: CbiQ; cl00463
1080230007233	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
1080230007234	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
1080230007235	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1080230007236	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1080230007237	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1080230007238	active site
1080230007239	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230007240	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
1080230007241	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
1080230007242	transcription-repair coupling factor (mfd); Region: mfd; TIGR00580
1080230007243	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
1080230007244	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230007245	ATP binding site [chemical binding]; other site
1080230007246	putative Mg++ binding site [ion binding]; other site
1080230007247	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1080230007248	nucleotide binding region [chemical binding]; other site
1080230007249	ATP-binding site [chemical binding]; other site
1080230007250	TRCF domain; Region: TRCF; cl04088
1080230007251	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
1080230007252	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011
1080230007253	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1080230007254	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
1080230007255	Walker A/P-loop; other site
1080230007256	ATP binding site [chemical binding]; other site
1080230007257	Q-loop/lid; other site
1080230007258	ABC transporter signature motif; other site
1080230007259	Walker B; other site
1080230007260	D-loop; other site
1080230007261	H-loop/switch region; other site
1080230007262	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1080230007263	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1080230007264	putative catalytic cysteine [active]
1080230007265	Protein of unknown function (DUF3177); Region: DUF3177; pfam11375
1080230007266	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230007267	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
1080230007268	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
1080230007269	putative active site [active]
1080230007270	putative NTP binding site [chemical binding]; other site
1080230007271	putative nucleic acid binding site [nucleotide binding]; other site
1080230007272	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1080230007273	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1080230007274	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230007275	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1080230007276	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1080230007277	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230007278	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1080230007279	IMP binding site; other site
1080230007280	dimer interface [polypeptide binding]; other site
1080230007281	interdomain contacts; other site
1080230007282	partial ornithine binding site; other site
1080230007283	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1080230007284	active site
1080230007285	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1080230007286	homodecamer interface [polypeptide binding]; other site
1080230007287	GTP cyclohydrolase I; Provisional; Region: PLN03044
1080230007288	active site
1080230007289	putative catalytic site residues [active]
1080230007290	zinc binding site [ion binding]; other site
1080230007291	GTP-CH-I/GFRP interaction surface; other site
1080230007292	competence/damage-inducible protein CinA N-terminal domain; Region: cinA_nterm; TIGR00200
1080230007293	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1080230007294	putative MPT binding site; other site
1080230007295	Competence-damaged protein; Region: CinA; cl00666
1080230007296	Restriction endonuclease; Region: Mrr_cat; cl00516
1080230007297	Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385
1080230007298	Stage II sporulation protein; Region: SpoIID; pfam08486
1080230007299	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1080230007300	active site residue [active]
1080230007301	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
1080230007302	RNA/DNA binding site [nucleotide binding]; other site
1080230007303	RRM dimerization site [polypeptide binding]; other site
1080230007304	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1080230007305	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1080230007306	active site
1080230007307	dimer interface [polypeptide binding]; other site
1080230007308	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1080230007309	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1080230007310	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
1080230007311	PLD-like domain; Region: PLDc_2; pfam13091
1080230007312	putative active site [active]
1080230007313	catalytic site [active]
1080230007314	Putative catalytic domain, repeat 2, of uncharacterized hypothetical proteins similar to Nuc, an endonuclease from Salmonella typhimurium; Region: PLDc_Nuc_like_unchar1_2; cd09173
1080230007315	PLD-like domain; Region: PLDc_2; pfam13091
1080230007316	putative active site [active]
1080230007317	catalytic site [active]
1080230007318	DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555
1080230007319	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1080230007320	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
1080230007321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
1080230007322	TIGR03442 family protein; Region: TIGR03442
1080230007323	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1080230007324	putative active site [active]
1080230007325	putative dimer interface [polypeptide binding]; other site
1080230007326	RNA polymerase sigma factor SigC; Validated; Region: PRK07598
1080230007327	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1080230007328	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230007329	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1080230007330	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230007331	DNA binding residues [nucleotide binding]
1080230007332	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
1080230007333	Cysteine-rich domain; Region: CCG; pfam02754
1080230007334	Cysteine-rich domain; Region: CCG; pfam02754
1080230007335	YGGT family; Region: YGGT; cl00508
1080230007336	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1080230007337	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230007338	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1080230007339	photosystem I assembly protein Ycf3; Region: ycf3; CHL00033
1080230007340	Protein of unknown function (DUF3252); Region: DUF3252; pfam11623
1080230007341	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230007342	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230007343	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1080230007344	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230007345	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1080230007346	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230007347	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1080230007348	active site
1080230007349	glutamyl-tRNA synthetase, bacterial family; Region: gltX_bact; TIGR00464
1080230007350	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1080230007351	HIGH motif; other site
1080230007352	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1080230007353	active site
1080230007354	KMSKS motif; other site
1080230007355	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
1080230007356	Predicted kinase [General function prediction only]; Region: COG0645
1080230007357	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
1080230007358	ATP-binding site [chemical binding]; other site
1080230007359	Gluconate-6-phosphate binding site [chemical binding]; other site
1080230007360	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
1080230007361	PPIC-type PPIASE domain; Region: Rotamase; cl08278
1080230007362	Ferredoxin thioredoxin reductase variable alpha chain; Region: FeThRed_A; pfam02941
1080230007363	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230007364	dimer interface [polypeptide binding]; other site
1080230007365	phosphorylation site [posttranslational modification]
1080230007366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230007367	ATP binding site [chemical binding]; other site
1080230007368	Mg2+ binding site [ion binding]; other site
1080230007369	G-X-G motif; other site
1080230007370	Protein of unknown function (DUF2839); Region: DUF2839; pfam10999
1080230007371	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230007372	Haemolytic domain; Region: Haemolytic; cl00506
1080230007373	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1080230007374	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1080230007375	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
1080230007376	substrate binding pocket [chemical binding]; other site
1080230007377	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1080230007378	B12 binding site [chemical binding]; other site
1080230007379	cobalt ligand [ion binding]; other site
1080230007380	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1080230007381	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230007382	Predicted NTPase (NACHT family) [Signal transduction mechanisms]; Region: COG5635
1080230007383	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230007384	putative active site [active]
1080230007385	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1080230007386	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
1080230007387	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
1080230007388	TPR repeat; Region: TPR_11; pfam13414
1080230007389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1080230007390	TPR repeat; Region: TPR_11; pfam13414
1080230007391	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1080230007392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1080230007393	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1080230007394	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1080230007395	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1080230007396	Helix-turn-helix domains; Region: HTH; cl00088
1080230007397	multidrug efflux protein; Reviewed; Region: PRK01766
1080230007398	MatE; Region: MatE; cl10513
1080230007399	MatE; Region: MatE; cl10513
1080230007400	Cellulose binding domain; Region: CBM_2; cl02709
1080230007401	Cellulose binding domain; Region: CBM_2; cl02709
1080230007402	endoglucanase; Region: PLN02308
1080230007403	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
1080230007404	ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566
1080230007405	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1080230007406	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1080230007407	cyanate hydratase; Validated; Region: PRK02866
1080230007408	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
1080230007409	Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate.  It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559
1080230007410	oligomer interface [polypeptide binding]; other site
1080230007411	active site
1080230007412	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1080230007413	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1080230007414	dimer interface [polypeptide binding]; other site
1080230007415	putative functional site; other site
1080230007416	putative MPT binding site; other site
1080230007417	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
1080230007418	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230007419	FeS/SAM binding site; other site
1080230007420	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1080230007421	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MoaC/MobA; Provisional; Region: PRK14500
1080230007422	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1080230007423	trimer interface [polypeptide binding]; other site
1080230007424	dimer interface [polypeptide binding]; other site
1080230007425	putative active site [active]
1080230007426	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1080230007427	GTP binding site; other site
1080230007428	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1080230007429	MoaE interaction surface [polypeptide binding]; other site
1080230007430	MoeB interaction surface [polypeptide binding]; other site
1080230007431	thiocarboxylated glycine; other site
1080230007432	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1080230007433	MoaE homodimer interface [polypeptide binding]; other site
1080230007434	MoaD interaction [polypeptide binding]; other site
1080230007435	active site residues [active]
1080230007436	Protein of unknown function (DUF4090); Region: DUF4090; pfam13319
1080230007437	Mg chelatase-related protein; Region: TIGR00368
1080230007438	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
1080230007439	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230007440	Walker A motif; other site
1080230007441	ATP binding site [chemical binding]; other site
1080230007442	Walker B motif; other site
1080230007443	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1080230007444	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
1080230007445	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1080230007446	Photosystem II protein; Region: PSII; cl08223
1080230007447	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230007448	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230007449	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230007450	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230007451	transcriptional regulator HdfR; Provisional; Region: PRK03601
1080230007452	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230007453	Protein of unknown function (DUF3257); Region: DUF3257; pfam11645
1080230007454	7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156
1080230007455	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1080230007456	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1080230007457	catalytic residue [active]
1080230007458	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1080230007459	active site
1080230007460	Protein of unknown function, DUF393; Region: DUF393; cl01136
1080230007461	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1080230007462	nudix motif; other site
1080230007463	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1080230007464	tetramerization interface [polypeptide binding]; other site
1080230007465	active site
1080230007466	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1080230007467	malate dehydrogenase; Reviewed; Region: PRK06223
1080230007468	NAD(P) binding site [chemical binding]; other site
1080230007469	dimer interface [polypeptide binding]; other site
1080230007470	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1080230007471	substrate binding site [chemical binding]; other site
1080230007472	Cyanobacterial and plant NDH-1 subunit O; Region: NdhO; pfam11910
1080230007473	Protein of unknown function (DUF2811); Region: DUF2811; pfam10929
1080230007474	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1080230007475	putative active site [active]
1080230007476	catalytic residue [active]
1080230007477	Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65); Region: PSRP-3_Ycf65; cl04793
1080230007478	Tic22-like family; Region: Tic22; cl04468
1080230007479	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
1080230007480	Receptor family ligand binding region; Region: ANF_receptor; pfam01094
1080230007481	putative ligand binding site [chemical binding]; other site
1080230007482	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1080230007483	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1080230007484	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007485	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1080230007486	active site
1080230007487	Ferredoxin thioredoxin reductase catalytic beta chain; Region: FeThRed_B; cl01977
1080230007488	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230007489	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230007490	Vitamin K epoxide reductase family; Region: VKOR; cl01729
1080230007491	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
1080230007492	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230007493	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
1080230007494	Flavin Reductases; Region: FlaRed; cl00801
1080230007495	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1080230007496	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1080230007497	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
1080230007498	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
1080230007499	chain length determinant protein tyrosine kinase EpsG; Region: EpsG; TIGR03029
1080230007500	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
1080230007501	putative rRNA binding site [nucleotide binding]; other site
1080230007502	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1080230007503	active site
1080230007504	DNA polymerase III subunit delta; Validated; Region: PRK07452
1080230007505	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1080230007506	Protein of unknown function (DUF2752); Region: DUF2752; pfam10825
1080230007507	Interferon-induced transmembrane protein; Region: CD225; pfam04505
1080230007508	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
1080230007509	CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964
1080230007510	putative active site; other site
1080230007511	signature motif; other site
1080230007512	putative triphosphate binding site [ion binding]; other site
1080230007513	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; cl12078
1080230007514	Cytochrome P450; Region: p450; pfam00067
1080230007515	Protein of unknown function (DUF2854); Region: DUF2854; pfam11016
1080230007516	acetyl-CoA synthetase; Provisional; Region: PRK00174
1080230007517	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1080230007518	AMP-binding enzyme; Region: AMP-binding; cl15778
1080230007519	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230007520	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
1080230007521	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1080230007522	Di-iron ligands [ion binding]; other site
1080230007523	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1080230007524	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1080230007525	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1080230007526	catalytic residue [active]
1080230007527	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; cl01604
1080230007528	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230007529	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1080230007530	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1080230007531	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1080230007532	NADP binding site [chemical binding]; other site
1080230007533	active site
1080230007534	putative substrate binding site [chemical binding]; other site
1080230007535	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
1080230007536	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230007537	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
1080230007538	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
1080230007539	alanine racemase; Region: alr; TIGR00492
1080230007540	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1080230007541	active site
1080230007542	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1080230007543	dimer interface [polypeptide binding]; other site
1080230007544	substrate binding site [chemical binding]; other site
1080230007545	catalytic residues [active]
1080230007546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1080230007547	PAS domain S-box; Region: sensory_box; TIGR00229
1080230007548	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230007549	putative active site [active]
1080230007550	heme pocket [chemical binding]; other site
1080230007551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230007552	PAS fold; Region: PAS_3; pfam08447
1080230007553	putative active site [active]
1080230007554	heme pocket [chemical binding]; other site
1080230007555	PAS fold; Region: PAS_4; pfam08448
1080230007556	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230007557	putative active site [active]
1080230007558	heme pocket [chemical binding]; other site
1080230007559	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230007560	PAS domain; Region: PAS_9; pfam13426
1080230007561	putative active site [active]
1080230007562	heme pocket [chemical binding]; other site
1080230007563	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230007564	metal binding site [ion binding]; metal-binding site
1080230007565	active site
1080230007566	I-site; other site
1080230007567	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230007568	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1080230007569	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230007570	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1080230007571	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1080230007572	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1080230007573	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230007574	dimer interface [polypeptide binding]; other site
1080230007575	conserved gate region; other site
1080230007576	putative PBP binding loops; other site
1080230007577	ABC-ATPase subunit interface; other site
1080230007578	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
1080230007579	replicative DNA helicase; Validated; Region: PRK07773
1080230007580	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1080230007581	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1080230007582	Walker A motif; other site
1080230007583	ATP binding site [chemical binding]; other site
1080230007584	Walker B motif; other site
1080230007585	DNA binding loops [nucleotide binding]
1080230007586	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1080230007587	protein-splicing catalytic site; other site
1080230007588	thioester formation/cholesterol transfer; other site
1080230007589	Hint (Hedgehog/Intein) domain C-terminal region; Region: HintC; cl16942
1080230007590	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007591	MoxR-like ATPases [General function prediction only]; Region: COG0714
1080230007592	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230007593	Walker A motif; other site
1080230007594	ATP binding site [chemical binding]; other site
1080230007595	Walker B motif; other site
1080230007596	arginine finger; other site
1080230007597	dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181
1080230007598	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1080230007599	NAD binding site [chemical binding]; other site
1080230007600	substrate binding site [chemical binding]; other site
1080230007601	homodimer interface [polypeptide binding]; other site
1080230007602	active site
1080230007603	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
1080230007604	elongation factor G; Reviewed; Region: PRK12740
1080230007605	G1 box; other site
1080230007606	putative GEF interaction site [polypeptide binding]; other site
1080230007607	GTP/Mg2+ binding site [chemical binding]; other site
1080230007608	Switch I region; other site
1080230007609	G2 box; other site
1080230007610	G3 box; other site
1080230007611	Switch II region; other site
1080230007612	G4 box; other site
1080230007613	G5 box; other site
1080230007614	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1080230007615	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1080230007616	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1080230007617	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1080230007618	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1080230007619	dimerization interface [polypeptide binding]; other site
1080230007620	putative ATP binding site [chemical binding]; other site
1080230007621	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230007622	S-adenosylmethionine binding site [chemical binding]; other site
1080230007623	ferrochelatase; Region: hemH; TIGR00109
1080230007624	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1080230007625	active site
1080230007626	C-terminal domain interface [polypeptide binding]; other site
1080230007627	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1080230007628	active site
1080230007629	N-terminal domain interface [polypeptide binding]; other site
1080230007630	Chlorophyll A-B binding protein; Region: Chloroa_b-bind; cl02879
1080230007631	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1080230007632	Amidase; Region: Amidase; cl11426
1080230007633	META domain; Region: META; cl01245
1080230007634	META domain; Region: META; cl01245
1080230007635	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230007636	ligand binding site [chemical binding]; other site
1080230007637	flexible hinge region; other site
1080230007638	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230007639	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1080230007640	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1080230007641	active site
1080230007642	NTP binding site [chemical binding]; other site
1080230007643	metal binding triad [ion binding]; metal-binding site
1080230007644	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1080230007645	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1080230007646	Hypothetical chloroplast protein Ycf34; Region: Ycf34; pfam10718
1080230007647	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07376
1080230007648	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1080230007649	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230007650	NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010
1080230007651	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
1080230007652	succinate dehydrogenase and fumarate reductase iron-sulfur protein; Region: dhsB; TIGR00384
1080230007653	AbrB-like transcriptional regulator; Region: AbrB-like; pfam14250
1080230007654	Rrf2 family protein; Region: rrf2_super; TIGR00738
1080230007655	Helix-turn-helix domains; Region: HTH; cl00088
1080230007656	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230007657	GAF domain; Region: GAF; cl15785
1080230007658	GAF domain; Region: GAF; cl15785
1080230007659	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230007660	metal binding site [ion binding]; metal-binding site
1080230007661	active site
1080230007662	I-site; other site
1080230007663	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230007664	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230007665	GAF domain; Region: GAF; cl15785
1080230007666	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230007667	metal binding site [ion binding]; metal-binding site
1080230007668	active site
1080230007669	I-site; other site
1080230007670	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1080230007671	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1080230007672	active site
1080230007673	(T/H)XGH motif; other site
1080230007674	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975
1080230007675	phosphodiesterase; Provisional; Region: PRK12704
1080230007676	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230007677	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1080230007678	putative binding surface; other site
1080230007679	active site
1080230007680	iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702
1080230007681	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1080230007682	putative DNA binding site [nucleotide binding]; other site
1080230007683	putative Zn2+ binding site [ion binding]; other site
1080230007684	Helix-turn-helix domains; Region: HTH; cl00088
1080230007685	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
1080230007686	putative ABC transporter; Region: ycf24; CHL00085
1080230007687	sulfate ABC transporter protein; Validated; Region: ycf16; CHL00131
1080230007688	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
1080230007689	Walker A/P-loop; other site
1080230007690	ATP binding site [chemical binding]; other site
1080230007691	Q-loop/lid; other site
1080230007692	ABC transporter signature motif; other site
1080230007693	Walker B; other site
1080230007694	D-loop; other site
1080230007695	H-loop/switch region; other site
1080230007696	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1080230007697	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
1080230007698	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1080230007699	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1080230007700	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1080230007701	catalytic residue [active]
1080230007702	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1080230007703	P loop; other site
1080230007704	Nucleotide binding site [chemical binding]; other site
1080230007705	arsenite-activated ATPase ArsA; Region: arsA; TIGR00345
1080230007706	DTAP/Switch II; other site
1080230007707	Switch I; other site
1080230007708	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1080230007709	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230007710	motif II; other site
1080230007711	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
1080230007712	dimer interface [polypeptide binding]; other site
1080230007713	active site
1080230007714	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1080230007715	active site
1080230007716	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
1080230007717	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1080230007718	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007719	Walker A motif; other site
1080230007720	ATP binding site [chemical binding]; other site
1080230007721	Walker B motif; other site
1080230007722	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1080230007723	RNA/DNA hybrid binding site [nucleotide binding]; other site
1080230007724	active site
1080230007725	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230007726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230007727	active site
1080230007728	phosphorylation site [posttranslational modification]
1080230007729	intermolecular recognition site; other site
1080230007730	dimerization interface [polypeptide binding]; other site
1080230007731	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230007732	DNA binding site [nucleotide binding]
1080230007733	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
1080230007734	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1080230007735	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230007736	FeS/SAM binding site; other site
1080230007737	helicase 45; Provisional; Region: PTZ00424
1080230007738	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1080230007739	ATP binding site [chemical binding]; other site
1080230007740	Mg++ binding site [ion binding]; other site
1080230007741	motif III; other site
1080230007742	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1080230007743	nucleotide binding region [chemical binding]; other site
1080230007744	ATP-binding site [chemical binding]; other site
1080230007745	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1080230007746	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007747	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
1080230007748	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1080230007749	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1080230007750	putative active site [active]
1080230007751	oxyanion strand; other site
1080230007752	catalytic triad [active]
1080230007753	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
1080230007754	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
1080230007755	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1080230007756	active site
1080230007757	dimer interface [polypeptide binding]; other site
1080230007758	motif 1; other site
1080230007759	motif 2; other site
1080230007760	motif 3; other site
1080230007761	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1080230007762	anticodon binding site; other site
1080230007763	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
1080230007764	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1080230007765	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007766	tocopherol O-methyltransferase; Region: PLN02244
1080230007767	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230007768	S-adenosylmethionine binding site [chemical binding]; other site
1080230007769	4-hydroxyphenylpyruvate dioxygenase; Region: 4HPPD; TIGR01263
1080230007770	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1080230007771	active site
1080230007772	metal binding site [ion binding]; metal-binding site
1080230007773	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1080230007774	active site
1080230007775	Fe binding site [ion binding]; other site
1080230007776	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
1080230007777	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1080230007778	NAD(P) binding site [chemical binding]; other site
1080230007779	catalytic residues [active]
1080230007780	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
1080230007781	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
1080230007782	Probable Catalytic site; other site
1080230007783	chaperone protein DnaJ; Provisional; Region: PRK14299
1080230007784	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1080230007785	HSP70 interaction site [polypeptide binding]; other site
1080230007786	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1080230007787	substrate binding site [polypeptide binding]; other site
1080230007788	dimer interface [polypeptide binding]; other site
1080230007789	O-methyltransferase; Region: Methyltransf_3; pfam01596
1080230007790	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230007791	S-adenosylmethionine binding site [chemical binding]; other site
1080230007792	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1080230007793	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230007794	Sulfate transporter family; Region: Sulfate_transp; cl15842
1080230007795	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1080230007796	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
1080230007797	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007798	Walker A/P-loop; other site
1080230007799	ATP binding site [chemical binding]; other site
1080230007800	Q-loop/lid; other site
1080230007801	ABC transporter signature motif; other site
1080230007802	Walker B; other site
1080230007803	D-loop; other site
1080230007804	H-loop/switch region; other site
1080230007805	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
1080230007806	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1080230007807	putative active site pocket [active]
1080230007808	4-fold oligomerization interface [polypeptide binding]; other site
1080230007809	metal binding residues [ion binding]; metal-binding site
1080230007810	3-fold/trimer interface [polypeptide binding]; other site
1080230007811	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230007812	putative active site [active]
1080230007813	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1080230007814	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230007815	S-adenosylmethionine binding site [chemical binding]; other site
1080230007816	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
1080230007817	tetramer interface [polypeptide binding]; other site
1080230007818	dimer interface [polypeptide binding]; other site
1080230007819	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230007820	active site
1080230007821	phosphorylation site [posttranslational modification]
1080230007822	intermolecular recognition site; other site
1080230007823	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
1080230007824	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
1080230007825	Walker A/P-loop; other site
1080230007826	ATP binding site [chemical binding]; other site
1080230007827	Q-loop/lid; other site
1080230007828	ABC transporter signature motif; other site
1080230007829	Walker B; other site
1080230007830	D-loop; other site
1080230007831	H-loop/switch region; other site
1080230007832	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1080230007833	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007834	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
1080230007835	Ycf66 protein N-terminus; Region: Ycf66_N; pfam07444
1080230007836	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1080230007837	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1080230007838	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007839	short chain dehydrogenase; Provisional; Region: PRK06197
1080230007840	NAD(P) binding site [chemical binding]; other site
1080230007841	active site
1080230007842	Predicted lipase [Lipid metabolism]; Region: COG3675
1080230007843	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is 'interfacial activation,' the process of...; Region: Lipase_3; cd00519
1080230007844	active site flap/lid [active]
1080230007845	nucleophilic elbow; other site
1080230007846	catalytic triad [active]
1080230007847	LL-diaminopimelate aminotransferase; Region: DAPAT_plant; TIGR03542
1080230007848	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1080230007849	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230007850	homodimer interface [polypeptide binding]; other site
1080230007851	catalytic residue [active]
1080230007852	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1080230007853	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230007854	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230007855	ligand binding site [chemical binding]; other site
1080230007856	flexible hinge region; other site
1080230007857	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230007858	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230007859	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230007860	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230007861	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1080230007862	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
1080230007863	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1080230007864	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1080230007865	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230007866	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1080230007867	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230007868	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230007869	PAS fold; Region: PAS_3; pfam08447
1080230007870	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1080230007871	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230007872	dimer interface [polypeptide binding]; other site
1080230007873	phosphorylation site [posttranslational modification]
1080230007874	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230007875	ATP binding site [chemical binding]; other site
1080230007876	Mg2+ binding site [ion binding]; other site
1080230007877	G-X-G motif; other site
1080230007878	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230007879	NMT1-like family; Region: NMT1_2; cl15260
1080230007880	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1080230007881	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230007882	Coenzyme A binding pocket [chemical binding]; other site
1080230007883	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1080230007884	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
1080230007885	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1080230007886	putative active site [active]
1080230007887	catalytic triad [active]
1080230007888	Domain of unknown function (DUF4214); Region: DUF4214; pfam13946
1080230007889	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1080230007890	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1080230007891	Protein of unknown function (DUF2808); Region: DUF2808; pfam10989
1080230007892	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02812
1080230007893	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1080230007894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1080230007895	active site
1080230007896	AAA domain; Region: AAA_26; pfam13500
1080230007897	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007898	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1080230007899	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
1080230007900	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
1080230007901	Creatinine amidohydrolase; Region: Creatininase; cl00618
1080230007902	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1080230007903	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1080230007904	non-specific DNA interactions [nucleotide binding]; other site
1080230007905	DNA binding site [nucleotide binding]
1080230007906	sequence specific DNA binding site [nucleotide binding]; other site
1080230007907	putative cAMP binding site [chemical binding]; other site
1080230007908	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
1080230007909	glucokinase, proteobacterial type; Region: glk; TIGR00749
1080230007910	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1080230007911	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230007912	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007913	Walker A/P-loop; other site
1080230007914	ATP binding site [chemical binding]; other site
1080230007915	Q-loop/lid; other site
1080230007916	ABC transporter signature motif; other site
1080230007917	Walker B; other site
1080230007918	D-loop; other site
1080230007919	H-loop/switch region; other site
1080230007920	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1080230007921	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230007922	putative substrate translocation pore; other site
1080230007923	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1080230007924	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1080230007925	Cl- selectivity filter; other site
1080230007926	Cl- binding residues [ion binding]; other site
1080230007927	pore gating glutamate residue; other site
1080230007928	dimer interface [polypeptide binding]; other site
1080230007929	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230007930	cobyric acid synthase CobQ; Region: cobQ; TIGR00313
1080230007931	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230007932	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1080230007933	catalytic triad [active]
1080230007934	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1080230007935	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1080230007936	catalytic loop [active]
1080230007937	iron binding site [ion binding]; other site
1080230007938	pyruvate kinase; Region: pyruv_kin; TIGR01064
1080230007939	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
1080230007940	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
1080230007941	HI0933-like protein; Region: HI0933_like; pfam03486
1080230007942	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230007943	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1080230007944	catalytic residues [active]
1080230007945	L-asparaginase II; Region: Asparaginase_II; cl01842
1080230007946	Protein of unknown function (DUF1230); Region: DUF1230; pfam06799
1080230007947	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
1080230007948	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1080230007949	active site
1080230007950	homodimer interface [polypeptide binding]; other site
1080230007951	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
1080230007952	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
1080230007953	homotrimer interaction site [polypeptide binding]; other site
1080230007954	active site
1080230007955	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1080230007956	putative metal binding site; other site
1080230007957	TPR repeat; Region: TPR_11; pfam13414
1080230007958	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230007959	binding surface
1080230007960	TPR motif; other site
1080230007961	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230007962	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230007963	binding surface
1080230007964	TPR motif; other site
1080230007965	TPR repeat; Region: TPR_11; pfam13414
1080230007966	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230007967	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1080230007968	Entner-Doudoroff aldolase; Region: eda; TIGR01182
1080230007969	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1080230007970	active site
1080230007971	intersubunit interface [polypeptide binding]; other site
1080230007972	catalytic residue [active]
1080230007973	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1080230007974	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
1080230007975	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1080230007976	Zn2+ binding site [ion binding]; other site
1080230007977	Mg2+ binding site [ion binding]; other site
1080230007978	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
1080230007979	VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465
1080230007980	metal ion-dependent adhesion site (MIDAS); other site
1080230007981	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
1080230007982	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1080230007983	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1080230007984	P-loop; other site
1080230007985	Magnesium ion binding site [ion binding]; other site
1080230007986	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1080230007987	Magnesium ion binding site [ion binding]; other site
1080230007988	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
1080230007989	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1080230007990	amidohydrolase; Region: amidohydrolases; TIGR01891
1080230007991	metal binding site [ion binding]; metal-binding site
1080230007992	dimer interface [polypeptide binding]; other site
1080230007993	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
1080230007994	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
1080230007995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230007996	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14457
1080230007997	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230007998	FeS/SAM binding site; other site
1080230007999	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230008000	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008001	NAD(P) binding site [chemical binding]; other site
1080230008002	Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; cl15292
1080230008003	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1080230008004	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008005	active site
1080230008006	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1080230008007	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1080230008008	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1080230008009	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230008010	ATP binding site [chemical binding]; other site
1080230008011	Mg2+ binding site [ion binding]; other site
1080230008012	G-X-G motif; other site
1080230008013	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1080230008014	Magnesium ion binding site [ion binding]; other site
1080230008015	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1080230008016	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1080230008017	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230008018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008019	active site
1080230008020	phosphorylation site [posttranslational modification]
1080230008021	intermolecular recognition site; other site
1080230008022	dimerization interface [polypeptide binding]; other site
1080230008023	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230008024	DNA binding site [nucleotide binding]
1080230008025	Ferredoxin-dependent bilin reductase; Region: Fe_bilin_red; cl07930
1080230008026	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230008027	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230008028	ThiC family; Region: ThiC; cl08031
1080230008029	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
1080230008030	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1080230008031	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
1080230008032	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1080230008033	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230008034	polyphosphate kinase; Provisional; Region: PRK05443
1080230008035	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1080230008036	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1080230008037	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1080230008038	putative domain interface [polypeptide binding]; other site
1080230008039	putative active site [active]
1080230008040	catalytic site [active]
1080230008041	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1080230008042	putative domain interface [polypeptide binding]; other site
1080230008043	putative active site [active]
1080230008044	catalytic site [active]
1080230008045	Septum formation topological specificity factor MinE; Region: MinE; cl00538
1080230008046	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1080230008047	Switch I; other site
1080230008048	Switch II; other site
1080230008049	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1080230008050	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1080230008051	Double zinc ribbon; Region: DZR; pfam12773
1080230008052	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
1080230008053	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230008054	phosphopeptide binding site; other site
1080230008055	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
1080230008056	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
1080230008057	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230008058	putative active site [active]
1080230008059	phosphoenolpyruvate synthase; Validated; Region: PRK06464
1080230008060	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1080230008061	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
1080230008062	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
1080230008063	PAS fold; Region: PAS_3; pfam08447
1080230008064	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1080230008065	PAS domain S-box; Region: sensory_box; TIGR00229
1080230008066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008067	putative active site [active]
1080230008068	heme pocket [chemical binding]; other site
1080230008069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008070	PAS fold; Region: PAS_3; pfam08447
1080230008071	putative active site [active]
1080230008072	heme pocket [chemical binding]; other site
1080230008073	GAF domain; Region: GAF; cl15785
1080230008074	GAF domain; Region: GAF_2; pfam13185
1080230008075	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230008076	metal binding site [ion binding]; metal-binding site
1080230008077	active site
1080230008078	I-site; other site
1080230008079	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1080230008080	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230008081	S-adenosylmethionine binding site [chemical binding]; other site
1080230008082	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
1080230008083	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230008084	FeS/SAM binding site; other site
1080230008085	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
1080230008086	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
1080230008087	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1080230008088	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1080230008089	Drosophila melanogaster CG11883 and related proteins, N-terminal metallophosphatase domain; Region: MPP_CG11883_N; cd07406
1080230008090	putative active site [active]
1080230008091	putative metal binding site [ion binding]; other site
1080230008092	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1080230008093	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
1080230008094	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230008095	Coenzyme A binding pocket [chemical binding]; other site
1080230008096	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
1080230008097	HerA helicase [Replication, recombination, and repair]; Region: COG0433
1080230008098	Domain of unknown function DUF87; Region: DUF87; pfam01935
1080230008099	Uncharacterized protein containing TOPRIM domain, potential nuclease [General function prediction only]; Region: COG4026
1080230008100	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230008101	Double zinc ribbon; Region: DZR; pfam12773
1080230008102	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1080230008103	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1080230008104	Protein of unknown function (DUF1822); Region: DUF1822; pfam08852
1080230008105	PAS domain S-box; Region: sensory_box; TIGR00229
1080230008106	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008107	putative active site [active]
1080230008108	heme pocket [chemical binding]; other site
1080230008109	PAS domain S-box; Region: sensory_box; TIGR00229
1080230008110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230008111	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008112	putative active site [active]
1080230008113	heme pocket [chemical binding]; other site
1080230008114	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1080230008115	PAS fold; Region: PAS_4; pfam08448
1080230008116	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1080230008117	Histidine kinase; Region: HisKA_3; pfam07730
1080230008118	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230008119	ATP binding site [chemical binding]; other site
1080230008120	Mg2+ binding site [ion binding]; other site
1080230008121	G-X-G motif; other site
1080230008122	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1080230008123	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008124	active site
1080230008125	phosphorylation site [posttranslational modification]
1080230008126	intermolecular recognition site; other site
1080230008127	dimerization interface [polypeptide binding]; other site
1080230008128	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230008129	DNA binding residues [nucleotide binding]
1080230008130	dimerization interface [polypeptide binding]; other site
1080230008131	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1080230008132	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1080230008133	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
1080230008134	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1080230008135	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008136	NAD(P) binding site [chemical binding]; other site
1080230008137	active site
1080230008138	CAAX protease self-immunity; Region: Abi; cl00558
1080230008139	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1080230008140	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1080230008141	NADP binding site [chemical binding]; other site
1080230008142	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_like_4; cd06152
1080230008143	homotrimer interaction site [polypeptide binding]; other site
1080230008144	putative active site [active]
1080230008145	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
1080230008146	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1080230008147	active site
1080230008148	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
1080230008149	bifunctional nicotinamide mononucleotide adenylyltransferase/ADP-ribose pyrophosphatase; Provisional; Region: PRK05379
1080230008150	Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional proteins, also containing a Nudix hydrolase domain; Region: NMNAT_Nudix; cd02168
1080230008151	active site
1080230008152	(T/H)XGH motif; other site
1080230008153	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1080230008154	nudix motif; other site
1080230008155	putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198
1080230008156	pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569
1080230008157	active site
1080230008158	HPP family; Region: HPP; pfam04982
1080230008159	Y-family of DNA polymerases; Region: PolY; cl12025
1080230008160	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1080230008161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230008162	ATP binding site [chemical binding]; other site
1080230008163	Mg2+ binding site [ion binding]; other site
1080230008164	G-X-G motif; other site
1080230008165	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230008166	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008167	active site
1080230008168	phosphorylation site [posttranslational modification]
1080230008169	intermolecular recognition site; other site
1080230008170	dimerization interface [polypeptide binding]; other site
1080230008171	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230008172	DNA binding site [nucleotide binding]
1080230008173	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1080230008174	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
1080230008175	The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes.  But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736
1080230008176	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1080230008177	catalytic residue [active]
1080230008178	H+ Antiporter protein; Region: 2A0121; TIGR00900
1080230008179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1080230008180	putative substrate translocation pore; other site
1080230008181	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1080230008182	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1080230008183	DNA binding residues [nucleotide binding]
1080230008184	dimer interface [polypeptide binding]; other site
1080230008185	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
1080230008186	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1080230008187	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1080230008188	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230008189	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230008190	Uncharacterized BCR, YnfA/UPF0060 family; Region: UPF0060; cl00757
1080230008191	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1080230008192	dimerization interface [polypeptide binding]; other site
1080230008193	putative DNA binding site [nucleotide binding]; other site
1080230008194	putative Zn2+ binding site [ion binding]; other site
1080230008195	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1080230008196	metal-binding site [ion binding]
1080230008197	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
1080230008198	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230008199	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
1080230008200	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230008201	dimer interface [polypeptide binding]; other site
1080230008202	phosphorylation site [posttranslational modification]
1080230008203	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230008204	ATP binding site [chemical binding]; other site
1080230008205	Mg2+ binding site [ion binding]; other site
1080230008206	G-X-G motif; other site
1080230008207	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230008208	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008209	active site
1080230008210	phosphorylation site [posttranslational modification]
1080230008211	intermolecular recognition site; other site
1080230008212	dimerization interface [polypeptide binding]; other site
1080230008213	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230008214	DNA binding site [nucleotide binding]
1080230008215	Domain of unknown function (DUF305); Region: DUF305; cl15795
1080230008216	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008217	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224
1080230008218	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008219	MSMEG_0570 family protein; Region: MSMEG_0570_fam; TIGR04042
1080230008220	AIR synthase-related protein, sll0787 family; Region: AIR_rel_sll0787; TIGR04049
1080230008221	AIR synthase (PurM) related protein, subgroup 3 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like3; cd02192
1080230008222	dimerization interface [polypeptide binding]; other site
1080230008223	putative ATP binding site [chemical binding]; other site
1080230008224	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230008225	radical SAM protein, MSMEG_0568 family; Region: rSAM_MSMEG_0568; TIGR04043
1080230008226	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230008227	FeS/SAM binding site; other site
1080230008228	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1080230008229	Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564
1080230008230	putative active site [active]
1080230008231	catalytic triad [active]
1080230008232	putative dimer interface [polypeptide binding]; other site
1080230008233	MSMEG_0572 family protein; Region: MSMEG_0572_fam; TIGR04044
1080230008234	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1080230008235	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008236	GAF domain; Region: GAF_2; pfam13185
1080230008237	GAF domain; Region: GAF; cl15785
1080230008238	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1080230008239	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230008240	DNA binding residues [nucleotide binding]
1080230008241	dimerization interface [polypeptide binding]; other site
1080230008242	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3558
1080230008243	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1080230008244	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
1080230008245	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008246	PAS fold; Region: PAS_3; pfam08447
1080230008247	putative active site [active]
1080230008248	heme pocket [chemical binding]; other site
1080230008249	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008250	PAS fold; Region: PAS_3; pfam08447
1080230008251	putative active site [active]
1080230008252	heme pocket [chemical binding]; other site
1080230008253	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008254	PAS fold; Region: PAS_3; pfam08447
1080230008255	putative active site [active]
1080230008256	heme pocket [chemical binding]; other site
1080230008257	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008258	PAS domain; Region: PAS_9; pfam13426
1080230008259	putative active site [active]
1080230008260	heme pocket [chemical binding]; other site
1080230008261	PAS domain S-box; Region: sensory_box; TIGR00229
1080230008262	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230008263	putative active site [active]
1080230008264	heme pocket [chemical binding]; other site
1080230008265	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230008266	metal binding site [ion binding]; metal-binding site
1080230008267	active site
1080230008268	I-site; other site
1080230008269	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230008270	phosphopeptide binding site; other site
1080230008271	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1080230008272	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1080230008273	phosphopeptide binding site; other site
1080230008274	The Eye Pigment Precursor Transporter (EPP) Family protein; Region: 3a01204; TIGR00955
1080230008275	ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR).  DR is a well-described phenomenon occurring in fungi and shares several similarities with processes...; Region: ABCG_EPDR; cd03213
1080230008276	Walker A/P-loop; other site
1080230008277	ATP binding site [chemical binding]; other site
1080230008278	Q-loop/lid; other site
1080230008279	ABC transporter signature motif; other site
1080230008280	Walker B; other site
1080230008281	D-loop; other site
1080230008282	H-loop/switch region; other site
1080230008283	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1080230008284	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1080230008285	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
1080230008286	Protein kinase domain; Region: Pkinase; pfam00069
1080230008287	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1080230008288	active site
1080230008289	ATP binding site [chemical binding]; other site
1080230008290	substrate binding site [chemical binding]; other site
1080230008291	activation loop (A-loop); other site
1080230008292	Bacterial SH3 domain; Region: SH3_3; cl02551
1080230008293	Domain of unknown function (DUF4189); Region: DUF4189; pfam13827
1080230008294	Proteolipid membrane potential modulator; Region: Pmp3; cl00431
1080230008295	5-oxoprolinase; Region: PLN02666
1080230008296	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1080230008297	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
1080230008298	CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891
1080230008299	putative active site [active]
1080230008300	putative metal binding residues [ion binding]; other site
1080230008301	signature motif; other site
1080230008302	putative dimer interface [polypeptide binding]; other site
1080230008303	putative phosphate binding site [ion binding]; other site
1080230008304	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1080230008305	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1080230008306	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1080230008307	DNA binding residues [nucleotide binding]
1080230008308	dimer interface [polypeptide binding]; other site
1080230008309	metal binding site [ion binding]; metal-binding site
1080230008310	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008311	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230008312	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008313	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328
1080230008314	GXWXG protein; Region: GXWXG; pfam14231
1080230008315	Domain of unknown function (DUF4334); Region: DUF4334; pfam14232
1080230008316	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230008317	Helix-turn-helix domains; Region: HTH; cl00088
1080230008318	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008319	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1080230008320	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008321	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230008322	Helix-turn-helix domains; Region: HTH; cl00088
1080230008323	Integrase core domain; Region: rve; cl01316
1080230008324	Integrase core domain; Region: rve; cl01316
1080230008325	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1080230008326	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
1080230008327	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1080230008328	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1080230008329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230008330	motif II; other site
1080230008331	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1080230008332	magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383
1080230008333	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
1080230008334	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
1080230008335	DNA polymerase I; Region: pola; TIGR00593
1080230008336	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1080230008337	active site
1080230008338	metal binding site 1 [ion binding]; metal-binding site
1080230008339	putative 5' ssDNA interaction site; other site
1080230008340	metal binding site 3; metal-binding site
1080230008341	metal binding site 2 [ion binding]; metal-binding site
1080230008342	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1080230008343	putative DNA binding site [nucleotide binding]; other site
1080230008344	putative metal binding site [ion binding]; other site
1080230008345	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1080230008346	active site
1080230008347	catalytic site [active]
1080230008348	substrate binding site [chemical binding]; other site
1080230008349	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1080230008350	active site
1080230008351	DNA binding site [nucleotide binding]
1080230008352	catalytic site [active]
1080230008353	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230008354	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230008355	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008356	DDE superfamily endonuclease; Region: DDE_4; cl15789
1080230008357	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
1080230008358	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
1080230008359	GIY-YIG motif/motif A; other site
1080230008360	active site
1080230008361	catalytic site [active]
1080230008362	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1080230008363	homotrimer interaction site [polypeptide binding]; other site
1080230008364	putative active site [active]
1080230008365	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1080230008366	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1080230008367	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1080230008368	NAD(P) binding site [chemical binding]; other site
1080230008369	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1080230008370	Predicted integral membrane protein [Function unknown]; Region: COG0392
1080230008371	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
1080230008372	4Fe-4S single cluster domain; Region: Fer4_15; pfam13459
1080230008373	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
1080230008374	Protein of unknown function (DUF1257); Region: DUF1257; cl06088
1080230008375	Protein of unknown function (DUF2997); Region: DUF2997; pfam11211
1080230008376	Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873
1080230008377	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1080230008378	PetM family of cytochrome b6f complex subunit 7; Region: PetM; pfam08041
1080230008379	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
1080230008380	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
1080230008381	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1080230008382	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
1080230008383	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
1080230008384	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
1080230008385	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
1080230008386	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1080230008387	Mg++ binding site [ion binding]; other site
1080230008388	putative catalytic motif [active]
1080230008389	putative substrate binding site [chemical binding]; other site
1080230008390	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1080230008391	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230008392	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
1080230008393	active site
1080230008394	ADP/pyrophosphate binding site [chemical binding]; other site
1080230008395	dimerization interface [polypeptide binding]; other site
1080230008396	allosteric effector site; other site
1080230008397	fructose-1,6-bisphosphate binding site; other site
1080230008398	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK07565
1080230008399	Dihydroorotate dehydrogenase (DHOD) like proteins. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD...; Region: DHOD_like; cd04739
1080230008400	putative active site [active]
1080230008401	putative FMN binding site [chemical binding]; other site
1080230008402	putative substrate binding site [chemical binding]; other site
1080230008403	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230008404	Domain of unknown function DUF29; Region: DUF29; pfam01724
1080230008405	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
1080230008406	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1080230008407	dimer interface [polypeptide binding]; other site
1080230008408	PYR/PP interface [polypeptide binding]; other site
1080230008409	TPP binding site [chemical binding]; other site
1080230008410	substrate binding site [chemical binding]; other site
1080230008411	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
1080230008412	Domain of unknown function; Region: EKR; cl11037
1080230008413	4Fe-4S binding domain; Region: Fer4; cl02805
1080230008414	4Fe-4S binding domain; Region: Fer4; cl02805
1080230008415	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
1080230008416	TPP-binding site [chemical binding]; other site
1080230008417	dimer interface [polypeptide binding]; other site
1080230008418	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
1080230008419	putative active site [active]
1080230008420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230008421	dimer interface [polypeptide binding]; other site
1080230008422	conserved gate region; other site
1080230008423	putative PBP binding loops; other site
1080230008424	ABC-ATPase subunit interface; other site
1080230008425	ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118
1080230008426	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230008427	Walker A/P-loop; other site
1080230008428	ATP binding site [chemical binding]; other site
1080230008429	Q-loop/lid; other site
1080230008430	ABC transporter signature motif; other site
1080230008431	Walker B; other site
1080230008432	D-loop; other site
1080230008433	H-loop/switch region; other site
1080230008434	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
1080230008435	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230008436	O-Antigen ligase; Region: Wzy_C; cl04850
1080230008437	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230008438	GAF domain; Region: GAF; cl15785
1080230008439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230008440	metal binding site [ion binding]; metal-binding site
1080230008441	active site
1080230008442	I-site; other site
1080230008443	Photosystem II complex subunit Ycf12; Region: PSII_Ycf12; cl12139
1080230008444	Flagellin N-methylase; Region: FliB; cl00497
1080230008445	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
1080230008446	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
1080230008447	putative ADP-binding pocket [chemical binding]; other site
1080230008448	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
1080230008449	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
1080230008450	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1080230008451	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1080230008452	putative binding surface; other site
1080230008453	active site
1080230008454	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1080230008455	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1080230008456	putative binding surface; other site
1080230008457	active site
1080230008458	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1080230008459	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230008460	ATP binding site [chemical binding]; other site
1080230008461	Mg2+ binding site [ion binding]; other site
1080230008462	G-X-G motif; other site
1080230008463	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
1080230008464	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230008465	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008466	active site
1080230008467	phosphorylation site [posttranslational modification]
1080230008468	intermolecular recognition site; other site
1080230008469	dimerization interface [polypeptide binding]; other site
1080230008470	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1080230008471	dimer interface [polypeptide binding]; other site
1080230008472	putative CheW interface [polypeptide binding]; other site
1080230008473	GAF domain; Region: GAF; cl15785
1080230008474	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230008475	GAF domain; Region: GAF; cl15785
1080230008476	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1080230008477	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1080230008478	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1080230008479	dimer interface [polypeptide binding]; other site
1080230008480	putative CheW interface [polypeptide binding]; other site
1080230008481	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1080230008482	putative CheA interaction surface; other site
1080230008483	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008484	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230008485	active site
1080230008486	phosphorylation site [posttranslational modification]
1080230008487	intermolecular recognition site; other site
1080230008488	dimerization interface [polypeptide binding]; other site
1080230008489	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230008490	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008491	active site
1080230008492	phosphorylation site [posttranslational modification]
1080230008493	intermolecular recognition site; other site
1080230008494	dimerization interface [polypeptide binding]; other site
1080230008495	Predicted protease with the C-terminal PDZ domain [General function prediction only]; Region: COG3975
1080230008496	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1080230008497	Zn binding site [ion binding]; other site
1080230008498	PDZ domain associated with archaeal and bacterial M61 glycyl-aminopeptidases. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) polypeptides and even to...; Region: PDZ_glycyl_aminopeptidase; cd00990
1080230008499	protein binding site [polypeptide binding]; other site
1080230008500	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1080230008501	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1080230008502	homodimer interface [polypeptide binding]; other site
1080230008503	substrate-cofactor binding pocket; other site
1080230008504	catalytic residue [active]
1080230008505	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
1080230008506	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1080230008507	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1080230008508	putative active site [active]
1080230008509	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1080230008510	putative active site [active]
1080230008511	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1080230008512	active site
1080230008513	dimer interfaces [polypeptide binding]; other site
1080230008514	catalytic residues [active]
1080230008515	putative lipid kinase; Reviewed; Region: PRK00861
1080230008516	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
1080230008517	aspartate aminotransferase; Provisional; Region: PRK05957
1080230008518	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1080230008519	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230008520	homodimer interface [polypeptide binding]; other site
1080230008521	catalytic residue [active]
1080230008522	D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813
1080230008523	carotene isomerase; Region: carot_isom; TIGR02730
1080230008524	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008525	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
1080230008526	4Fe-4S binding domain; Region: Fer4; cl02805
1080230008527	Iron-Sulfur binding protein C terminal; Region: LdpA_C; pfam12617
1080230008528	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
1080230008529	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230008530	DRTGG domain; Region: DRTGG; cl12147
1080230008531	Helix-turn-helix domains; Region: HTH; cl00088
1080230008532	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
1080230008533	The C-terminal substrate binding of LysR-type transcriptional regulator (CbbR) of RubisCO operon, which is involved in the carbon dioxide fixation, contains the type 2 periplasmic binding fold; Region: PBP2_CbbR_RubisCO_like; cd08419
1080230008534	putative dimerization interface [polypeptide binding]; other site
1080230008535	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1080230008536	NMT1-like family; Region: NMT1_2; cl15260
1080230008537	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1080230008538	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230008539	dimer interface [polypeptide binding]; other site
1080230008540	conserved gate region; other site
1080230008541	ABC-ATPase subunit interface; other site
1080230008542	S-layer homology domain; Region: SLH; pfam00395
1080230008543	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230008544	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230008545	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
1080230008546	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1080230008547	Walker A/P-loop; other site
1080230008548	ATP binding site [chemical binding]; other site
1080230008549	Q-loop/lid; other site
1080230008550	ABC transporter signature motif; other site
1080230008551	Walker B; other site
1080230008552	D-loop; other site
1080230008553	H-loop/switch region; other site
1080230008554	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1080230008555	NMT1-like family; Region: NMT1_2; cl15260
1080230008556	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
1080230008557	nitrate transport ATP-binding subunits C and D; Region: ntrCD; TIGR01184
1080230008558	Walker A/P-loop; other site
1080230008559	ATP binding site [chemical binding]; other site
1080230008560	Q-loop/lid; other site
1080230008561	ABC transporter signature motif; other site
1080230008562	Walker B; other site
1080230008563	D-loop; other site
1080230008564	H-loop/switch region; other site
1080230008565	NAD(P)H-quinone oxidoreductase subunit D4; Validated; Region: PRK06473
1080230008566	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230008567	NAD(P)H-quinone oxidoreductase subunit F; Validated; Region: PRK07390
1080230008568	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1080230008569	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
1080230008570	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
1080230008571	RNA/DNA binding site [nucleotide binding]; other site
1080230008572	RRM dimerization site [polypeptide binding]; other site
1080230008573	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
1080230008574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230008575	S-adenosylmethionine binding site [chemical binding]; other site
1080230008576	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230008577	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1080230008578	oligomerization interface [polypeptide binding]; other site
1080230008579	active site
1080230008580	metal binding site [ion binding]; metal-binding site
1080230008581	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1080230008582	Ligand Binding Site [chemical binding]; other site
1080230008583	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1080230008584	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1080230008585	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1080230008586	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1080230008587	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
1080230008588	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230008589	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1080230008590	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230008591	ABC-type spermidine/putrescine transport system, permease component I [Amino acid transport and metabolism]; Region: PotB; COG1176
1080230008592	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230008593	conserved gate region; other site
1080230008594	dimer interface [polypeptide binding]; other site
1080230008595	putative PBP binding loops; other site
1080230008596	ABC-ATPase subunit interface; other site
1080230008597	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1080230008598	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230008599	putative PBP binding loops; other site
1080230008600	dimer interface [polypeptide binding]; other site
1080230008601	ABC-ATPase subunit interface; other site
1080230008602	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1080230008603	substrate binding pocket [chemical binding]; other site
1080230008604	substrate-Mg2+ binding site; other site
1080230008605	aspartate-rich region 1; other site
1080230008606	aspartate-rich region 2; other site
1080230008607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1080230008608	dimerization interface [polypeptide binding]; other site
1080230008609	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1080230008610	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230008611	dimer interface [polypeptide binding]; other site
1080230008612	phosphorylation site [posttranslational modification]
1080230008613	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230008614	ATP binding site [chemical binding]; other site
1080230008615	Mg2+ binding site [ion binding]; other site
1080230008616	G-X-G motif; other site
1080230008617	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1080230008618	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1080230008619	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1080230008620	Tetratricopeptide repeat; Region: TPR_6; pfam13174
1080230008621	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
1080230008622	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1080230008623	catalytic residue [active]
1080230008624	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1080230008625	active site
1080230008626	catalytic triad [active]
1080230008627	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1080230008628	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1080230008629	substrate binding site [chemical binding]; other site
1080230008630	active site
1080230008631	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
1080230008632	ATP adenylyltransferase; Region: ATP_transf; pfam09830
1080230008633	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine...; Region: adenosine_kinase; cd01168
1080230008634	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1080230008635	substrate binding site [chemical binding]; other site
1080230008636	ATP binding site [chemical binding]; other site
1080230008637	magnesium Mg(2+) and cobalt Co(2+) transport protein (corA); Region: corA; TIGR00383
1080230008638	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
1080230008639	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1080230008640	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1080230008641	catalytic residue [active]
1080230008642	putative FPP diphosphate  binding site; other site
1080230008643	putative FPP binding hydrophobic cleft; other site
1080230008644	dimer interface [polypeptide binding]; other site
1080230008645	putative IPP diphosphate binding site; other site
1080230008646	TIGR00159 family protein; Region: TIGR00159
1080230008647	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1080230008648	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1080230008649	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1080230008650	active site
1080230008651	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1080230008652	substrate binding site [chemical binding]; other site
1080230008653	catalytic residues [active]
1080230008654	dimer interface [polypeptide binding]; other site
1080230008655	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1080230008656	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1080230008657	G1 box; other site
1080230008658	GTP/Mg2+ binding site [chemical binding]; other site
1080230008659	Switch I region; other site
1080230008660	G2 box; other site
1080230008661	Switch II region; other site
1080230008662	G3 box; other site
1080230008663	G4 box; other site
1080230008664	G5 box; other site
1080230008665	Domain of unknown function (DUF697); Region: DUF697; cl12064
1080230008666	arginine-tRNA ligase; Region: PLN02286
1080230008667	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
1080230008668	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1080230008669	active site
1080230008670	HIGH motif; other site
1080230008671	KMSK motif region; other site
1080230008672	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1080230008673	tRNA binding surface [nucleotide binding]; other site
1080230008674	anticodon binding site; other site
1080230008675	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1080230008676	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1080230008677	Ligand binding site; other site
1080230008678	Putative Catalytic site; other site
1080230008679	DXD motif; other site
1080230008680	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1080230008681	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1080230008682	catalytic triad [active]
1080230008683	Clp protease; Region: CLP_protease; pfam00574
1080230008684	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1080230008685	oligomer interface [polypeptide binding]; other site
1080230008686	active site residues [active]
1080230008687	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1080230008688	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1080230008689	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230008690	catalytic residue [active]
1080230008691	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230008692	binding surface
1080230008693	TPR motif; other site
1080230008694	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230008695	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230008696	binding surface
1080230008697	TPR motif; other site
1080230008698	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230008699	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230008700	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230008701	binding surface
1080230008702	TPR motif; other site
1080230008703	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230008704	binding surface
1080230008705	TPR motif; other site
1080230008706	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230008707	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230008708	binding surface
1080230008709	TPR motif; other site
1080230008710	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1080230008711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4995
1080230008712	CHAT domain; Region: CHAT; pfam12770
1080230008713	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1080230008714	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
1080230008715	Walker A/P-loop; other site
1080230008716	ATP binding site [chemical binding]; other site
1080230008717	Q-loop/lid; other site
1080230008718	ABC transporter signature motif; other site
1080230008719	Walker B; other site
1080230008720	D-loop; other site
1080230008721	H-loop/switch region; other site
1080230008722	TM2 domain; Region: TM2; cl00984
1080230008723	Domain of unknown function (DUF3598); Region: DUF3598; pfam12204
1080230008724	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
1080230008725	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1080230008726	active site
1080230008727	catalytic tetrad [active]
1080230008728	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
1080230008729	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1080230008730	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1080230008731	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
1080230008732	putative dimer interface [polypeptide binding]; other site
1080230008733	putative anticodon binding site; other site
1080230008734	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1080230008735	homodimer interface [polypeptide binding]; other site
1080230008736	motif 1; other site
1080230008737	motif 2; other site
1080230008738	active site
1080230008739	motif 3; other site
1080230008740	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1080230008741	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008742	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
1080230008743	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1080230008744	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1080230008745	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008746	AIR carboxylase; Region: AIRC; cl00310
1080230008747	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1080230008748	dimer interface [polypeptide binding]; other site
1080230008749	ssDNA binding site [nucleotide binding]; other site
1080230008750	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1080230008751	UbiA prenyltransferase family; Region: UbiA; cl00337
1080230008752	D2 subunit  of photosystem II (PS II); Region: Photosystem-II_D2; cd09288
1080230008753	D1 interface; other site
1080230008754	chlorophyll binding site; other site
1080230008755	pheophytin binding site; other site
1080230008756	beta carotene binding site; other site
1080230008757	cytochrome b559 beta interface; other site
1080230008758	quinone binding site; other site
1080230008759	cytochrome b559 alpha interface; other site
1080230008760	protein J interface; other site
1080230008761	protein H interface; other site
1080230008762	protein X interface; other site
1080230008763	core light harvesting protein interface; other site
1080230008764	protein L interface; other site
1080230008765	CP43 interface; other site
1080230008766	protein T interface; other site
1080230008767	Fe binding site [ion binding]; other site
1080230008768	protein M interface; other site
1080230008769	Mn-stabilizing polypeptide interface; other site
1080230008770	bromide binding site; other site
1080230008771	cytochrome c-550 interface; other site
1080230008772	ParA-like protein; Provisional; Region: PHA02518
1080230008773	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1080230008774	P-loop; other site
1080230008775	Magnesium ion binding site [ion binding]; other site
1080230008776	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1080230008777	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230008778	Walker A motif; other site
1080230008779	ATP binding site [chemical binding]; other site
1080230008780	Walker B motif; other site
1080230008781	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
1080230008782	ATP phosphoribosyltransferase; Region: HisG; cl15266
1080230008783	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14360
1080230008784	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1080230008785	Substrate binding site; other site
1080230008786	Mg++ binding site; other site
1080230008787	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1080230008788	active site
1080230008789	substrate binding site [chemical binding]; other site
1080230008790	CoA binding site [chemical binding]; other site
1080230008791	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
1080230008792	GTPase RsgA; Reviewed; Region: PRK12289
1080230008793	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1080230008794	RNA binding site [nucleotide binding]; other site
1080230008795	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1080230008796	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1080230008797	GTP/Mg2+ binding site [chemical binding]; other site
1080230008798	G4 box; other site
1080230008799	G5 box; other site
1080230008800	G1 box; other site
1080230008801	Switch I region; other site
1080230008802	G2 box; other site
1080230008803	G3 box; other site
1080230008804	Switch II region; other site
1080230008805	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1080230008806	CPxP  motif; other site
1080230008807	chaperone protein DnaJ; Provisional; Region: PRK14293
1080230008808	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1080230008809	HSP70 interaction site [polypeptide binding]; other site
1080230008810	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1080230008811	substrate binding site [polypeptide binding]; other site
1080230008812	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1080230008813	Zn binding sites [ion binding]; other site
1080230008814	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1080230008815	dimer interface [polypeptide binding]; other site
1080230008816	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
1080230008817	active site
1080230008818	putative DNA-binding cleft [nucleotide binding]; other site
1080230008819	dimer interface [polypeptide binding]; other site
1080230008820	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in cysteine...; Region: CysQ; cd01638
1080230008821	active site
1080230008822	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1080230008823	active site
1080230008824	ribulose/triose binding site [chemical binding]; other site
1080230008825	phosphate binding site [ion binding]; other site
1080230008826	substrate (anthranilate) binding pocket [chemical binding]; other site
1080230008827	product (indole) binding pocket [chemical binding]; other site
1080230008828	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1080230008829	Ion channel; Region: Ion_trans_2; cl11596
1080230008830	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1080230008831	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008832	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
1080230008833	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1080230008834	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
1080230008835	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1080230008836	Walker A motif; other site
1080230008837	ATP binding site [chemical binding]; other site
1080230008838	Walker B motif; other site
1080230008839	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
1080230008840	Clp protease; Region: CLP_protease; pfam00574
1080230008841	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1080230008842	oligomer interface [polypeptide binding]; other site
1080230008843	active site residues [active]
1080230008844	trigger factor; Provisional; Region: tig; PRK01490
1080230008845	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
1080230008846	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1080230008847	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1080230008848	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008849	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
1080230008850	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1080230008851	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1080230008852	dimer interface [polypeptide binding]; other site
1080230008853	active site
1080230008854	catalytic residue [active]
1080230008855	conserved hypothetical protein; Region: MG423; TIGR00649
1080230008856	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1080230008857	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1080230008858	dephospho-CoA kinase; Region: TIGR00152
1080230008859	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1080230008860	CoA-binding site [chemical binding]; other site
1080230008861	ATP-binding [chemical binding]; other site
1080230008862	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1080230008863	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230008864	Phosphoketolase [Carbohydrate transport and metabolism]; Region: COG3957
1080230008865	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1080230008866	TPP-binding site [chemical binding]; other site
1080230008867	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1080230008868	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164
1080230008869	active site
1080230008870	putative substrate binding region [chemical binding]; other site
1080230008871	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the metalloprotease peptidase M50.  CBS is a small domain originally identified in cystathionine beta-synthase and subsequently found in a wide...; Region: CBS_pair_M50_like; cd04801
1080230008872	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1080230008873	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1080230008874	catalytic residue [active]
1080230008875	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
1080230008876	putative active site [active]
1080230008877	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
1080230008878	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398
1080230008879	FIST N domain; Region: FIST; cl10701
1080230008880	FIST C domain; Region: FIST_C; pfam10442
1080230008881	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1080230008882	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1080230008883	HIGH motif; other site
1080230008884	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1080230008885	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1080230008886	active site
1080230008887	KMSKS motif; other site
1080230008888	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1080230008889	tRNA binding surface [nucleotide binding]; other site
1080230008890	anticodon binding site; other site
1080230008891	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1080230008892	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
1080230008893	NADH dehydrogenase subunit 6; Region: ndhG; CHL00016
1080230008894	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
1080230008895	NADH dehydrogenase subunit J; Provisional; Region: PRK06439
1080230008896	NADH-plastoquinone oxidoreductase subunit I protein; Region: ndhI; TIGR00403
1080230008897	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1080230008898	NADH dehydrogenase; Region: NADHdh; cl00469
1080230008899	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1080230008900	quinone interaction residues [chemical binding]; other site
1080230008901	Dihydroorotate dehydrogenase [Nucleotide transport and metabolism]; Region: PyrD; COG0167
1080230008902	active site
1080230008903	catalytic residues [active]
1080230008904	FMN binding site [chemical binding]; other site
1080230008905	substrate binding site [chemical binding]; other site
1080230008906	Fe-S metabolism associated domain; Region: SufE; cl00951
1080230008907	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
1080230008908	N- and C-terminal domain interface [polypeptide binding]; other site
1080230008909	D-xylulose kinase; Region: XylB; TIGR01312
1080230008910	active site
1080230008911	MgATP binding site [chemical binding]; other site
1080230008912	catalytic site [active]
1080230008913	metal binding site [ion binding]; metal-binding site
1080230008914	carbohydrate binding site [chemical binding]; other site
1080230008915	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
1080230008916	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
1080230008917	Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603
1080230008918	Zn binding site [ion binding]; other site
1080230008919	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK07403
1080230008920	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230008921	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
1080230008922	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1080230008923	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1080230008924	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1080230008925	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1080230008926	UDP-N-acetylenolpyruvoylglucosamine reductase; Region: murB; TIGR00179
1080230008927	FAD binding domain; Region: FAD_binding_4; pfam01565
1080230008928	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1080230008929	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
1080230008930	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
1080230008931	heme binding site [chemical binding]; other site
1080230008932	ferroxidase pore; other site
1080230008933	ferroxidase diiron center [ion binding]; other site
1080230008934	Protein of unknown function (DUF3146); Region: DUF3146; pfam11344
1080230008935	recombination protein RecR; Reviewed; Region: recR; PRK00076
1080230008936	RecR protein; Region: RecR; pfam02132
1080230008937	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1080230008938	putative active site [active]
1080230008939	putative metal-binding site [ion binding]; other site
1080230008940	tetramer interface [polypeptide binding]; other site
1080230008941	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1080230008942	Amidinotransferase; Region: Amidinotransf; cl12043
1080230008943	TIGR00300 family protein; Region: TIGR00300
1080230008944	LOR/SDH bifunctional enzyme conserved region; Region: Saccharop_dh_N; pfam04455
1080230008945	Predicted GTPase [General function prediction only]; Region: COG3596
1080230008946	YfjP GTPase; Region: YfjP; cd11383
1080230008947	G1 box; other site
1080230008948	GTP/Mg2+ binding site [chemical binding]; other site
1080230008949	Switch I region; other site
1080230008950	G2 box; other site
1080230008951	Switch II region; other site
1080230008952	G3 box; other site
1080230008953	G4 box; other site
1080230008954	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230008955	GAF domain; Region: GAF; cl15785
1080230008956	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
1080230008957	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1080230008958	SWIM zinc finger; Region: SWIM; cl15408
1080230008959	Protein of unknown function (DUF3370); Region: DUF3370; pfam11850
1080230008960	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230008961	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230008962	active site
1080230008963	phosphorylation site [posttranslational modification]
1080230008964	intermolecular recognition site; other site
1080230008965	dimerization interface [polypeptide binding]; other site
1080230008966	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230008967	DNA binding site [nucleotide binding]
1080230008968	Bacterial family of Mg++ dependent phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate inositol monophosphate or similar substrates; Region: Bacterial_IMPase_like_2; cd01643
1080230008969	active site
1080230008970	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1080230008971	Helix-turn-helix domains; Region: HTH; cl00088
1080230008972	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1080230008973	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1080230008974	NIL domain; Region: NIL; cl09633
1080230008975	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230008976	dimer interface [polypeptide binding]; other site
1080230008977	conserved gate region; other site
1080230008978	putative PBP binding loops; other site
1080230008979	ABC-ATPase subunit interface; other site
1080230008980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1080230008981	dimer interface [polypeptide binding]; other site
1080230008982	conserved gate region; other site
1080230008983	putative PBP binding loops; other site
1080230008984	ABC-ATPase subunit interface; other site
1080230008985	Part of the ABC transporter complex cysAWTP involved in sulfate import.  Responsible for energy coupling to the transport system.  The complex is composed of two ATP-binding proteins (cysA), two transmembrane proteins (cysT and cysW), and a...; Region: ABC_CysA_sulfate_importer; cd03296
1080230008986	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
1080230008987	Walker A/P-loop; other site
1080230008988	ATP binding site [chemical binding]; other site
1080230008989	Q-loop/lid; other site
1080230008990	ABC transporter signature motif; other site
1080230008991	Walker B; other site
1080230008992	D-loop; other site
1080230008993	H-loop/switch region; other site
1080230008994	TOBE domain; Region: TOBE_2; cl01440
1080230008995	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
1080230008996	Type IV pilin PilA; Region: Pilin_PilA; pfam14245
1080230008997	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1080230008998	Chromate transporter; Region: Chromate_transp; pfam02417
1080230008999	Chromate transporter; Region: Chromate_transp; pfam02417
1080230009000	Phycobilisome protein; Region: Phycobilisome; cl08227
1080230009001	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1080230009002	SNF2 Helicase protein; Region: DUF3670; pfam12419
1080230009003	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230009004	ATP binding site [chemical binding]; other site
1080230009005	putative Mg++ binding site [ion binding]; other site
1080230009006	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1080230009007	nucleotide binding region [chemical binding]; other site
1080230009008	ATP-binding site [chemical binding]; other site
1080230009009	Rhomboid family; Region: Rhomboid; cl11446
1080230009010	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
1080230009011	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1080230009012	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
1080230009013	GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100
1080230009014	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
1080230009015	G1 box; other site
1080230009016	GTP/Mg2+ binding site [chemical binding]; other site
1080230009017	Switch I region; other site
1080230009018	G2 box; other site
1080230009019	Switch II region; other site
1080230009020	G3 box; other site
1080230009021	G4 box; other site
1080230009022	G5 box; other site
1080230009023	Domain of unknown function (DUF697); Region: DUF697; cl12064
1080230009024	elongation factor G; Reviewed; Region: PRK00007
1080230009025	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1080230009026	G1 box; other site
1080230009027	putative GEF interaction site [polypeptide binding]; other site
1080230009028	GTP/Mg2+ binding site [chemical binding]; other site
1080230009029	Switch I region; other site
1080230009030	G2 box; other site
1080230009031	G3 box; other site
1080230009032	Switch II region; other site
1080230009033	G4 box; other site
1080230009034	G5 box; other site
1080230009035	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1080230009036	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1080230009037	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1080230009038	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
1080230009039	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1080230009040	FeS/SAM binding site; other site
1080230009041	NifU-like domain; Region: NifU; cl00484
1080230009042	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1080230009043	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009044	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1080230009045	Domain of unknown function (DUF4346); Region: DUF4346; pfam14251
1080230009046	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase [Amino acid transport and metabolism]; Region: HisA; COG0106
1080230009047	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1080230009048	catalytic residues [active]
1080230009049	L-aspartate oxidase; Provisional; Region: PRK07395
1080230009050	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009051	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1080230009052	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; cl01891
1080230009053	Photosystem I psaG / psaK; Region: PSI_PSAK; cl11425
1080230009054	RNA polymerase sigma factor RpoD; Validated; Region: PRK07406
1080230009055	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230009056	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1080230009057	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230009058	DNA binding residues [nucleotide binding]
1080230009059	Domain of unknown function (DUF427); Region: DUF427; cl00998
1080230009060	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230009061	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1080230009062	aspartate kinase; Provisional; Region: PRK07431
1080230009063	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1080230009064	putative nucleotide binding site [chemical binding]; other site
1080230009065	putative catalytic residues [active]
1080230009066	putative Mg ion binding site [ion binding]; other site
1080230009067	putative aspartate binding site [chemical binding]; other site
1080230009068	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1080230009069	putative allosteric regulatory site; other site
1080230009070	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1080230009071	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1080230009072	putative allosteric regulatory site; other site
1080230009073	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1080230009074	Uncharacterized protein containing a TIR (Toll-Interleukin 1-resistance) domain [Function unknown]; Region: COG4916
1080230009075	TIR domain; Region: TIR_2; cl15770
1080230009076	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1080230009077	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1080230009078	active site
1080230009079	Zn binding site [ion binding]; other site
1080230009080	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1080230009081	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009082	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
1080230009083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230009084	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230009085	arginine decarboxylase; Provisional; Region: PRK05354
1080230009086	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830
1080230009087	dimer interface [polypeptide binding]; other site
1080230009088	active site
1080230009089	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1080230009090	catalytic residues [active]
1080230009091	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1080230009092	Quinolinate synthetase A protein; Region: NadA; cl00420
1080230009093	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1080230009094	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
1080230009095	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
1080230009096	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
1080230009097	substrate binding site [chemical binding]; other site
1080230009098	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
1080230009099	substrate binding site [chemical binding]; other site
1080230009100	ligand binding site [chemical binding]; other site
1080230009101	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1080230009102	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1080230009103	active site
1080230009104	dimer interface [polypeptide binding]; other site
1080230009105	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1080230009106	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1080230009107	active site
1080230009108	FMN binding site [chemical binding]; other site
1080230009109	substrate binding site [chemical binding]; other site
1080230009110	3Fe-4S cluster binding site [ion binding]; other site
1080230009111	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1080230009112	domain interface; other site
1080230009113	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1080230009114	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009115	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1080230009116	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
1080230009117	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1080230009118	catalytic site [active]
1080230009119	subunit interface [polypeptide binding]; other site
1080230009120	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1080230009121	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1080230009122	DNA-binding interface [nucleotide binding]; DNA binding site
1080230009123	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1080230009124	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1080230009125	active site
1080230009126	Substrate binding site; other site
1080230009127	Mg++ binding site; other site
1080230009128	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1080230009129	putative trimer interface [polypeptide binding]; other site
1080230009130	putative CoA binding site [chemical binding]; other site
1080230009131	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1080230009132	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
1080230009133	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1080230009134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009135	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1080230009136	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1080230009137	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1080230009138	shikimate binding site; other site
1080230009139	NAD(P) binding site [chemical binding]; other site
1080230009140	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
1080230009141	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
1080230009142	dimer interface [polypeptide binding]; other site
1080230009143	motif 1; other site
1080230009144	active site
1080230009145	motif 2; other site
1080230009146	motif 3; other site
1080230009147	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1080230009148	GSH binding site [chemical binding]; other site
1080230009149	catalytic residues [active]
1080230009150	Phosphotransferase enzyme family; Region: APH; pfam01636
1080230009151	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
1080230009152	active site
1080230009153	ATP binding site [chemical binding]; other site
1080230009154	RNA polymerase sigma factor SigF; Reviewed; Region: PRK07408
1080230009155	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1080230009156	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1080230009157	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1080230009158	DNA binding residues [nucleotide binding]
1080230009159	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1080230009160	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1080230009161	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1080230009162	active site
1080230009163	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
1080230009164	structural tetrad; other site
1080230009165	chromosome segregation protein; Provisional; Region: PRK02224
1080230009166	MgtE intracellular N domain; Region: MgtE_N; cl15244
1080230009167	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl01155
1080230009168	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1080230009169	AIR carboxylase; Region: AIRC; cl00310
1080230009170	Peptidase family M23; Region: Peptidase_M23; pfam01551
1080230009171	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
1080230009172	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
1080230009173	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
1080230009174	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1080230009175	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
1080230009176	Domain of unknown function (DUF370); Region: DUF370; cl00898
1080230009177	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1080230009178	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230009179	ligand binding site [chemical binding]; other site
1080230009180	flexible hinge region; other site
1080230009181	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
1080230009182	Protein of unknown function (DUF3352); Region: DUF3352; pfam11832
1080230009183	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
1080230009184	Predicted membrane protein (DUF2231); Region: DUF2231; cl01730
1080230009185	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1080230009186	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1080230009187	Fasciclin domain; Region: Fasciclin; cl02663
1080230009188	DevC protein; Region: devC; TIGR01185
1080230009189	FtsX-like permease family; Region: FtsX; cl15850
1080230009190	ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971
1080230009191	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230009192	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1080230009193	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1080230009194	putative active site [active]
1080230009195	CAAX protease self-immunity; Region: Abi; cl00558
1080230009196	Domain of unknown function (DUF1815); Region: DUF1815; pfam08844
1080230009197	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1080230009198	GAF domain; Region: GAF; cl15785
1080230009199	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1080230009200	PAS domain S-box; Region: sensory_box; TIGR00229
1080230009201	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230009202	putative active site [active]
1080230009203	heme pocket [chemical binding]; other site
1080230009204	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1080230009205	PAS domain; Region: PAS_9; pfam13426
1080230009206	putative active site [active]
1080230009207	heme pocket [chemical binding]; other site
1080230009208	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1080230009209	dimer interface [polypeptide binding]; other site
1080230009210	phosphorylation site [posttranslational modification]
1080230009211	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230009212	ATP binding site [chemical binding]; other site
1080230009213	Mg2+ binding site [ion binding]; other site
1080230009214	G-X-G motif; other site
1080230009215	Phycobilisome Linker polypeptide; Region: PBS_linker_poly; pfam00427
1080230009216	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1080230009217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230009218	active site
1080230009219	phosphorylation site [posttranslational modification]
1080230009220	intermolecular recognition site; other site
1080230009221	dimerization interface [polypeptide binding]; other site
1080230009222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1080230009223	DNA binding site [nucleotide binding]
1080230009224	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230009225	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1080230009226	Integrase core domain; Region: rve; cl01316
1080230009227	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1080230009228	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1080230009229	substrate binding site [chemical binding]; other site
1080230009230	ligand binding site [chemical binding]; other site
1080230009231	Response regulator receiver domain; Region: Response_reg; pfam00072
1080230009232	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1080230009233	active site
1080230009234	phosphorylation site [posttranslational modification]
1080230009235	intermolecular recognition site; other site
1080230009236	dimerization interface [polypeptide binding]; other site
1080230009237	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1080230009238	glucosylglycerol 3-phosphatase; Region: salt_tol_Pase; TIGR02399
1080230009239	Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase); Region: Salt_tol_Pase; pfam09506
1080230009240	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1080230009241	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
1080230009242	Walker A/P-loop; other site
1080230009243	ATP binding site [chemical binding]; other site
1080230009244	Q-loop/lid; other site
1080230009245	ABC transporter signature motif; other site
1080230009246	Walker B; other site
1080230009247	D-loop; other site
1080230009248	H-loop/switch region; other site
1080230009249	TOBE domain; Region: TOBE_2; cl01440
1080230009250	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
1080230009251	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1080230009252	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
1080230009253	active site
1080230009254	substrate binding site [chemical binding]; other site
1080230009255	catalytic site [active]
1080230009256	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1080230009257	photochlorophyllide reductase subunit L; Region: chlL; CHL00072
1080230009258	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
1080230009259	P-loop; other site
1080230009260	Pchlide_reductase_N: N protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_N; cd01979
1080230009261	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
1080230009262	Domain of unknown function (DUF4278); Region: DUF4278; pfam14105
1080230009263	TPR repeat; Region: TPR_11; pfam13414
1080230009264	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230009265	binding surface
1080230009266	TPR motif; other site
1080230009267	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1080230009268	TPR repeat; Region: TPR_11; pfam13414
1080230009269	binding surface
1080230009270	TPR motif; other site
1080230009271	Tetratricopeptide repeat; Region: TPR_9; pfam13371
1080230009272	enolase; Provisional; Region: eno; PRK00077
1080230009273	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1080230009274	dimer interface [polypeptide binding]; other site
1080230009275	metal binding site [ion binding]; metal-binding site
1080230009276	substrate binding pocket [chemical binding]; other site
1080230009277	TAT (twin-arginine translocation) pathway signal sequence; Region: TAT_signal; pfam10518
1080230009278	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1080230009279	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1080230009280	transmembrane helices; other site
1080230009281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911
1080230009282	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1080230009283	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
1080230009284	Domain of unknown function (DUF4327); Region: DUF4327; pfam14217
1080230009285	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1080230009286	LabA_like proteins; Region: LabA; cd10911
1080230009287	putative metal binding site [ion binding]; other site
1080230009288	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
1080230009289	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
1080230009290	phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132
1080230009291	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
1080230009292	active site
1080230009293	substrate binding site [chemical binding]; other site
1080230009294	metal binding site [ion binding]; metal-binding site
1080230009295	KaiA domain; Region: KaiA; pfam07688
1080230009296	KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978
1080230009297	tetramer interface [polypeptide binding]; other site
1080230009298	dimer interface [polypeptide binding]; other site
1080230009299	circadian clock protein KaiC; Region: circ_KaiC; TIGR02655
1080230009300	KaiC is a circadian clock protein primarily found in cyanobacteria KaiC is a RecA-like ATPase, having both Walker A and Walker B motifs. A related protein is found in archaea; Region: KaiC; cd01124
1080230009301	Walker A motif; other site
1080230009302	ATP binding site [chemical binding]; other site
1080230009303	Walker B motif; other site
1080230009304	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230009305	ATP binding site [chemical binding]; other site
1080230009306	Walker B motif; other site
1080230009307	Domain of unknown function (DUF4114); Region: DUF4114; pfam13448
1080230009308	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1080230009309	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230009310	Tryptophan-rich Synechocystis species C-terminal domain; Region: W_rich_C; pfam07483
1080230009311	RTX toxin acyltransferase family; Region: HlyC; cl01131
1080230009312	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1080230009313	Coenzyme A binding pocket [chemical binding]; other site
1080230009314	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
1080230009315	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the 'double-glycine' leader peptides from the precursors of various bacteriocins; Region: Peptidase_C39B; cd02418
1080230009316	putative active site [active]
1080230009317	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
1080230009318	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230009319	Walker A/P-loop; other site
1080230009320	ATP binding site [chemical binding]; other site
1080230009321	Q-loop/lid; other site
1080230009322	ABC transporter signature motif; other site
1080230009323	Walker B; other site
1080230009324	D-loop; other site
1080230009325	H-loop/switch region; other site
1080230009326	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
1080230009327	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1080230009328	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1080230009329	metal binding site [ion binding]; metal-binding site
1080230009330	dimer interface [polypeptide binding]; other site
1080230009331	S-layer homology domain; Region: SLH; pfam00395
1080230009332	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
1080230009333	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1080230009334	catalytic core [active]
1080230009335	Photosystem I reaction centre subunit XI; Region: PsaL; cl03651
1080230009336	Photosystem I reaction centre subunit VIII; Region: PSI_8; cl08205
1080230009337	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
1080230009338	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1080230009339	active site
1080230009340	homodimer interface [polypeptide binding]; other site
1080230009341	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1080230009342	metal binding site [ion binding]; metal-binding site
1080230009343	active site
1080230009344	I-site; other site
1080230009345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5381
1080230009346	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
1080230009347	Protein of unknown function (DUF3172); Region: DUF3172; pfam11371
1080230009348	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
1080230009349	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
1080230009350	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
1080230009351	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
1080230009352	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
1080230009353	Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520
1080230009354	Surface antigen; Region: Bac_surface_Ag; cl03097
1080230009355	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1080230009356	C-terminal domain interface [polypeptide binding]; other site
1080230009357	GSH binding site (G-site) [chemical binding]; other site
1080230009358	dimer interface [polypeptide binding]; other site
1080230009359	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1080230009360	substrate binding pocket (H-site) [chemical binding]; other site
1080230009361	N-terminal domain interface [polypeptide binding]; other site
1080230009362	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009363	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1080230009364	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1080230009365	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009366	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1080230009367	diaminopimelate epimerase; Region: PLN02536
1080230009368	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1080230009369	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1080230009370	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1080230009371	inhibitor-cofactor binding pocket; inhibition site
1080230009372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1080230009373	catalytic residue [active]
1080230009374	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1080230009375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944
1080230009376	phosphorylation site [posttranslational modification]
1080230009377	intermolecular recognition site; other site
1080230009378	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1080230009379	DNA binding residues [nucleotide binding]
1080230009380	dimerization interface [polypeptide binding]; other site
1080230009381	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1080230009382	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
1080230009383	Uncharacterized conserved protein [Function unknown]; Region: COG5464
1080230009384	Protein of unknown function (DUF2887); Region: DUF2887; pfam11103
1080230009385	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
1080230009386	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
1080230009387	Nitric oxide reductase large subunit [Inorganic ion transport and metabolism]; Region: NorB; COG3256
1080230009388	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1080230009389	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1080230009390	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230009391	ligand binding site [chemical binding]; other site
1080230009392	flexible hinge region; other site
1080230009393	Helix-turn-helix domains; Region: HTH; cl00088
1080230009394	Tubulin like; Region: Tubulin_2; pfam13809
1080230009395	Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581
1080230009396	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1080230009397	ATP binding site [chemical binding]; other site
1080230009398	putative Mg++ binding site [ion binding]; other site
1080230009399	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1080230009400	nucleotide binding region [chemical binding]; other site
1080230009401	ATP-binding site [chemical binding]; other site
1080230009402	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
1080230009403	Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322
1080230009404	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719
1080230009405	GIY-YIG motif/motif A; other site
1080230009406	active site
1080230009407	catalytic site [active]
1080230009408	metal binding site [ion binding]; metal-binding site
1080230009409	Dehydratase family; Region: ILVD_EDD; cl00340
1080230009410	putative phosphoketolase; Provisional; Region: PRK05261
1080230009411	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
1080230009412	TPP-binding site; other site
1080230009413	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894
1080230009414	XFP C-terminal domain; Region: XFP_C; pfam09363
1080230009415	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1080230009416	hydrophobic ligand binding site; other site
1080230009417	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1080230009418	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1080230009419	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1080230009420	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
1080230009421	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02755
1080230009422	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1080230009423	RNA binding site [nucleotide binding]; other site
1080230009424	active site
1080230009425	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1080230009426	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230009427	motif II; other site
1080230009428	Peptidase S8 family domain, uncharacterized subfamily 2; Region: Peptidases_S8_2; cd07488
1080230009429	putative catalytic residues [active]
1080230009430	putative active site [active]
1080230009431	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230009432	Transposase; Region: HTH_Tnp_IS630; pfam01710
1080230009433	Helix-turn-helix domains; Region: HTH; cl00088
1080230009434	Integrase core domain; Region: rve; cl01316
1080230009435	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230009436	DDE superfamily endonuclease; Region: DDE_5; cl02413
1080230009437	heat shock protein 90; Provisional; Region: PRK05218
1080230009438	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1080230009439	ATP binding site [chemical binding]; other site
1080230009440	Mg2+ binding site [ion binding]; other site
1080230009441	G-X-G motif; other site
1080230009442	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862
1080230009443	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1080230009444	ligand binding site; other site
1080230009445	oligomer interface; other site
1080230009446	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1080230009447	dimer interface [polypeptide binding]; other site
1080230009448	N-terminal domain interface [polypeptide binding]; other site
1080230009449	sulfate 1 binding site; other site
1080230009450	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
1080230009451	Bacterial SH3 domain; Region: SH3_3; cl02551
1080230009452	Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217
1080230009453	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1080230009454	RF-1 domain; Region: RF-1; cl02875
1080230009455	RF-1 domain; Region: RF-1; cl02875
1080230009456	Protein of unknown function (DUF3727); Region: DUF3727; pfam12527
1080230009457	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1080230009458	D1, D2 subunits of photosystem II  (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220
1080230009459	pheophytin binding site; other site
1080230009460	chlorophyll binding site; other site
1080230009461	quinone binding site; other site
1080230009462	Fe binding site [ion binding]; other site
1080230009463	Phospholipid methyltransferase; Region: PEMT; cl00763
1080230009464	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230009465	S-adenosylmethionine binding site [chemical binding]; other site
1080230009466	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1080230009467	active site residue [active]
1080230009468	cytochrome b6-f complex iron-sulfur subunit; Provisional; Region: PRK13474
1080230009469	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1080230009470	iron-sulfur cluster [ion binding]; other site
1080230009471	[2Fe-2S] cluster binding site [ion binding]; other site
1080230009472	Predicted membrane protein (DUF2214); Region: DUF2214; cl01427
1080230009473	PspA/IM30 family; Region: PspA_IM30; pfam04012
1080230009474	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1080230009475	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1080230009476	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1080230009477	Protein of unknown function (DUF1269); Region: DUF1269; cl01978
1080230009478	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1080230009479	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1080230009480	putative NAD(P) binding site [chemical binding]; other site
1080230009481	putative substrate binding site [chemical binding]; other site
1080230009482	catalytic Zn binding site [ion binding]; other site
1080230009483	structural Zn binding site [ion binding]; other site
1080230009484	dimer interface [polypeptide binding]; other site
1080230009485	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
1080230009486	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1080230009487	ANP binding site [chemical binding]; other site
1080230009488	Substrate Binding Site II [chemical binding]; other site
1080230009489	Substrate Binding Site I [chemical binding]; other site
1080230009490	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1080230009491	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1080230009492	motif II; other site
1080230009493	phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161
1080230009494	ATP-grasp domain; Region: ATP-grasp_4; cl03087
1080230009495	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1080230009496	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230009497	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1080230009498	Protein of unknown function (DUF3529); Region: DUF3529; pfam12046
1080230009499	Protein of unknown function (DUF2993); Region: DUF2993; pfam11209
1080230009500	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1080230009501	extended (e) SDRs; Region: SDR_e; cd08946
1080230009502	NAD(P) binding site [chemical binding]; other site
1080230009503	active site
1080230009504	substrate binding site [chemical binding]; other site
1080230009505	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1080230009506	ABC_KpsT_Wzt   The KpsT/Wzt ABC transporter subfamily is involved in extracellular polysaccharide export.  Among the variety of membrane-linked or extracellular polysaccharides excreted by bacteria, only capsular polysaccharides, lipopolysaccharides, and...; Region: ABC_KpsT_Wzt; cd03220
1080230009507	Walker A/P-loop; other site
1080230009508	ATP binding site [chemical binding]; other site
1080230009509	Q-loop/lid; other site
1080230009510	ABC transporter signature motif; other site
1080230009511	Walker B; other site
1080230009512	D-loop; other site
1080230009513	H-loop/switch region; other site
1080230009514	ABC-2 type transporter; Region: ABC2_membrane; cl11417
1080230009515	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1080230009516	dimer interface [polypeptide binding]; other site
1080230009517	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1080230009518	putative radical transfer pathway; other site
1080230009519	diiron center [ion binding]; other site
1080230009520	tyrosyl radical; other site
1080230009521	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
1080230009522	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1080230009523	putative substrate binding site [chemical binding]; other site
1080230009524	nucleotide binding site [chemical binding]; other site
1080230009525	nucleotide binding site [chemical binding]; other site
1080230009526	homodimer interface [polypeptide binding]; other site
1080230009527	Predicted GTPase [General function prediction only]; Region: COG2403
1080230009528	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230009529	Uncharacterized BCR, COG1649; Region: DUF187; cl15398
1080230009530	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230009531	ligand binding site [chemical binding]; other site
1080230009532	flexible hinge region; other site
1080230009533	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1080230009534	protein RecA; Region: tigrfam_recA; TIGR02012
1080230009535	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230009536	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1080230009537	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1080230009538	FtsX-like permease family; Region: FtsX; cl15850
1080230009539	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1080230009540	metal binding site 2 [ion binding]; metal-binding site
1080230009541	putative DNA binding helix; other site
1080230009542	metal binding site 1 [ion binding]; metal-binding site
1080230009543	dimer interface [polypeptide binding]; other site
1080230009544	structural Zn2+ binding site [ion binding]; other site
1080230009545	Creatinine amidohydrolase; Region: Creatininase; cl00618
1080230009546	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1080230009547	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1080230009548	purine monophosphate binding site [chemical binding]; other site
1080230009549	dimer interface [polypeptide binding]; other site
1080230009550	putative catalytic residues [active]
1080230009551	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1080230009552	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1080230009553	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1080230009554	S-adenosylmethionine binding site [chemical binding]; other site
1080230009555	Protein of unknown function (DUF3067); Region: DUF3067; pfam11267
1080230009556	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1080230009557	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1080230009558	active site
1080230009559	ATP binding site [chemical binding]; other site
1080230009560	substrate binding site [chemical binding]; other site
1080230009561	activation loop (A-loop); other site
1080230009562	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1080230009563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1080230009564	DNA polymerase III subunit alpha; Reviewed; Region: PRK09532
1080230009565	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
1080230009566	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1080230009567	protein-splicing catalytic site; other site
1080230009568	thioester formation/cholesterol transfer; other site
1080230009569	GTP-binding protein LepA; Provisional; Region: PRK05433
1080230009570	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1080230009571	G1 box; other site
1080230009572	putative GEF interaction site [polypeptide binding]; other site
1080230009573	GTP/Mg2+ binding site [chemical binding]; other site
1080230009574	Switch I region; other site
1080230009575	G2 box; other site
1080230009576	G3 box; other site
1080230009577	Switch II region; other site
1080230009578	G4 box; other site
1080230009579	G5 box; other site
1080230009580	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1080230009581	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1080230009582	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1080230009583	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1080230009584	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1080230009585	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1080230009586	putative dimer interface [polypeptide binding]; other site
1080230009587	N-terminal domain interface [polypeptide binding]; other site
1080230009588	putative substrate binding pocket (H-site) [chemical binding]; other site
1080230009589	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
1080230009590	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
1080230009591	putative active site [active]
1080230009592	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1080230009593	ligand binding site [chemical binding]; other site
1080230009594	flexible hinge region; other site
1080230009595	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1080230009596	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
1080230009597	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1080230009598	metal binding site [ion binding]; metal-binding site
1080230009599	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1080230009600	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
1080230009601	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
1080230009602	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496