-- dump date 20120504_163807 -- class Genbank::misc_feature -- table misc_feature_note -- id note 644966000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 644966000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 644966000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966000004 Walker A motif; other site 644966000005 ATP binding site [chemical binding]; other site 644966000006 Walker B motif; other site 644966000007 arginine finger; other site 644966000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 644966000009 DnaA box-binding interface [nucleotide binding]; other site 644966000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 644966000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 644966000012 putative DNA binding surface [nucleotide binding]; other site 644966000013 dimer interface [polypeptide binding]; other site 644966000014 beta-clamp/clamp loader binding surface; other site 644966000015 beta-clamp/translesion DNA polymerase binding surface; other site 644966000016 recombination protein F; Reviewed; Region: recF; PRK00064 644966000017 RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage. When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242 644966000018 Walker A/P-loop; other site 644966000019 ATP binding site [chemical binding]; other site 644966000020 Q-loop/lid; other site 644966000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966000022 ABC transporter signature motif; other site 644966000023 Walker B; other site 644966000024 D-loop; other site 644966000025 H-loop/switch region; other site 644966000026 Protein of unknown function (DUF721); Region: DUF721; cl02324 644966000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 644966000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966000029 Mg2+ binding site [ion binding]; other site 644966000030 G-X-G motif; other site 644966000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 644966000032 anchoring element; other site 644966000033 dimer interface [polypeptide binding]; other site 644966000034 ATP binding site [chemical binding]; other site 644966000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 644966000036 active site 644966000037 putative metal-binding site [ion binding]; other site 644966000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 644966000039 DNA gyrase subunit A; Validated; Region: PRK05560 644966000040 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 644966000041 CAP-like domain; other site 644966000042 active site 644966000043 primary dimer interface [polypeptide binding]; other site 644966000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644966000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644966000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644966000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644966000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644966000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 644966000050 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 644966000051 dimerization interface [polypeptide binding]; other site 644966000052 ATP binding site [chemical binding]; other site 644966000053 seryl-tRNA synthetase; Provisional; Region: PRK05431 644966000054 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 644966000055 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 644966000056 dimer interface [polypeptide binding]; other site 644966000057 active site 644966000058 motif 1; other site 644966000059 motif 2; other site 644966000060 motif 3; other site 644966000061 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 644966000062 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 644966000063 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 644966000064 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 644966000065 Int/Topo IB signature motif; other site 644966000066 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 644966000067 Domain of unknown function (DUF955); Region: DUF955; cl01076 644966000068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644966000069 non-specific DNA binding site [nucleotide binding]; other site 644966000070 salt bridge; other site 644966000071 sequence-specific DNA binding site [nucleotide binding]; other site 644966000072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644966000073 salt bridge; other site 644966000074 non-specific DNA binding site [nucleotide binding]; other site 644966000075 sequence-specific DNA binding site [nucleotide binding]; other site 644966000076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644966000077 non-specific DNA binding site [nucleotide binding]; other site 644966000078 salt bridge; other site 644966000079 sequence-specific DNA binding site [nucleotide binding]; other site 644966000080 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 644966000081 RecT family; Region: RecT; cl04285 644966000082 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 644966000083 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 644966000084 active site 644966000085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966000086 Walker A motif; other site 644966000087 ATP binding site [chemical binding]; other site 644966000088 Walker B motif; other site 644966000089 arginine finger; other site 644966000090 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 644966000091 Uncharacterized small protein (DUF2292); Region: DUF2292; cl02371 644966000092 positive control sigma-like factor; Validated; Region: PRK06930 644966000093 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 644966000094 DNA binding residues [nucleotide binding] 644966000095 Uncharacterized conserved protein [Function unknown]; Region: COG5323 644966000096 Phage-related protein [Function unknown]; Region: COG4695; cl01923 644966000097 Phage portal protein; Region: Phage_portal; pfam04860 644966000098 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 644966000099 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 644966000100 Phage capsid family; Region: Phage_capsid; pfam05065 644966000101 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 644966000102 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 644966000103 oligomerization interface [polypeptide binding]; other site 644966000104 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 644966000105 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 644966000106 Phage major tail protein 2; Region: Phage_tail_2; cl11463 644966000107 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 644966000108 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 644966000109 Phage-related protein [Function unknown]; Region: COG4722; cl15832 644966000110 Phage tail protein; Region: Sipho_tail; pfam05709 644966000111 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 644966000112 Protein of unknown function (DUF1565); Region: DUF1565; pfam07602 644966000113 Holin family; Region: Phage_holin_4; cl01989 644966000114 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644966000115 active site 644966000116 metal binding site [ion binding]; metal-binding site 644966000117 S-layer homology domain; Region: SLH; pfam00395 644966000118 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644966000119 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 644966000120 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 644966000121 Spore germination protein; Region: Spore_permease; cl15802 644966000122 QueT transporter; Region: QueT; cl01932 644966000123 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 644966000124 nucleoside/Zn binding site; other site 644966000125 dimer interface [polypeptide binding]; other site 644966000126 catalytic motif [active] 644966000127 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 644966000128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966000129 Walker A motif; other site 644966000130 ATP binding site [chemical binding]; other site 644966000131 Walker B motif; other site 644966000132 arginine finger; other site 644966000133 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 644966000134 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 644966000135 recombination protein RecR; Reviewed; Region: recR; PRK00076 644966000136 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 644966000137 RecR protein; Region: RecR; pfam02132 644966000138 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 644966000139 putative active site [active] 644966000140 putative metal-binding site [ion binding]; other site 644966000141 tetramer interface [polypeptide binding]; other site 644966000142 Protein of unknown function (DUF2508); Region: DUF2508; pfam10704 644966000143 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 644966000144 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644966000145 active site 644966000146 HIGH motif; other site 644966000147 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 644966000148 active site 644966000149 KMSKS motif; other site 644966000150 thymidylate kinase; Validated; Region: tmk; PRK00698 644966000151 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 644966000152 TMP-binding site; other site 644966000153 ATP-binding site [chemical binding]; other site 644966000154 Nitrogen regulatory protein P-II; Region: P-II; cl00412 644966000155 DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177 644966000156 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966000157 Predicted methyltransferases [General function prediction only]; Region: COG0313 644966000158 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 644966000159 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966000160 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 644966000161 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 644966000162 active site 644966000163 HIGH motif; other site 644966000164 KMSKS motif; other site 644966000165 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 644966000166 tRNA binding surface [nucleotide binding]; other site 644966000167 anticodon binding site; other site 644966000168 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 644966000169 dimer interface [polypeptide binding]; other site 644966000170 putative tRNA-binding site [nucleotide binding]; other site 644966000171 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 644966000172 active site 644966000173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966000174 Protein of unknown function (DUF458); Region: DUF458; cl00861 644966000175 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 644966000176 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 644966000177 pur operon repressor; Provisional; Region: PRK09213 644966000178 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 644966000179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644966000180 active site 644966000181 threonine dehydratase; Provisional; Region: PRK08198 644966000182 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 644966000183 tetramer interface [polypeptide binding]; other site 644966000184 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966000185 catalytic residue [active] 644966000186 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 644966000187 SpoVG; Region: SpoVG; cl00915 644966000188 Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018 644966000189 dimer interface [polypeptide binding]; other site 644966000190 catalytic triad [active] 644966000191 RDD family; Region: RDD; cl00746 644966000192 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 644966000193 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 644966000194 Substrate binding site; other site 644966000195 Mg++ binding site; other site 644966000196 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 644966000197 active site 644966000198 substrate binding site [chemical binding]; other site 644966000199 CoA binding site [chemical binding]; other site 644966000200 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 644966000201 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 644966000202 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644966000203 active site 644966000204 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 644966000205 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 644966000206 5S rRNA interface [nucleotide binding]; other site 644966000207 CTC domain interface [polypeptide binding]; other site 644966000208 L16 interface [polypeptide binding]; other site 644966000209 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 644966000210 putative active site [active] 644966000211 catalytic residue [active] 644966000212 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 644966000213 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 644966000214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644966000215 ATP binding site [chemical binding]; other site 644966000216 putative Mg++ binding site [ion binding]; other site 644966000217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644966000218 nucleotide binding region [chemical binding]; other site 644966000219 ATP-binding site [chemical binding]; other site 644966000220 TRCF domain; Region: TRCF; cl04088 644966000221 stage V sporulation protein T; Region: spore_V_T; TIGR02851 644966000222 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966000223 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 644966000224 homodimer interface [polypeptide binding]; other site 644966000225 metal binding site [ion binding]; metal-binding site 644966000226 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs'; Region: NTP-PPase_MazG_Cterm; cd11529 644966000227 homodimer interface [polypeptide binding]; other site 644966000228 active site 644966000229 putative chemical substrate binding site [chemical binding]; other site 644966000230 metal binding site [ion binding]; metal-binding site 644966000231 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 644966000232 IHF - DNA interface [nucleotide binding]; other site 644966000233 IHF dimer interface [polypeptide binding]; other site 644966000234 YabP family; Region: YabP; cl06766 644966000235 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 644966000236 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 644966000237 Septum formation initiator; Region: DivIC; cl11433 644966000238 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 644966000239 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966000240 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644966000241 Flavin Reductases; Region: FlaRed; cl00801 644966000242 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 644966000243 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 644966000244 trimerization site [polypeptide binding]; other site 644966000245 active site 644966000246 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 644966000247 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 644966000248 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966000249 catalytic residue [active] 644966000250 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 644966000251 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 644966000252 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 644966000253 FeS assembly ATPase SufC; Region: sufC; TIGR01978 644966000254 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 644966000255 Walker A/P-loop; other site 644966000256 ATP binding site [chemical binding]; other site 644966000257 Q-loop/lid; other site 644966000258 ABC transporter signature motif; other site 644966000259 Walker B; other site 644966000260 D-loop; other site 644966000261 H-loop/switch region; other site 644966000262 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 644966000263 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 644966000264 oligomer interface [polypeptide binding]; other site 644966000265 active site 644966000266 metal binding site [ion binding]; metal-binding site 644966000267 Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881 644966000268 Iron-sulfur protein interface; other site 644966000269 proximal heme binding site [chemical binding]; other site 644966000270 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 644966000271 putative Iron-sulfur protein interface [polypeptide binding]; other site 644966000272 putative proximal heme binding site [chemical binding]; other site 644966000273 putative SdhC-like subunit interface [polypeptide binding]; other site 644966000274 putative distal heme binding site [chemical binding]; other site 644966000275 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 644966000276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966000277 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 644966000278 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 644966000279 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 644966000280 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920 644966000281 EamA-like transporter family; Region: EamA; cl01037 644966000282 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 644966000283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644966000284 active site 644966000285 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 644966000286 Uncharacterized ACR, COG2135; Region: DUF159; cl03646 644966000287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644966000288 non-specific DNA binding site [nucleotide binding]; other site 644966000289 salt bridge; other site 644966000290 sequence-specific DNA binding site [nucleotide binding]; other site 644966000291 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 644966000292 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 644966000293 active site 644966000294 catalytic site [active] 644966000295 substrate binding site [chemical binding]; other site 644966000296 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 644966000297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966000298 S-adenosylmethionine binding site [chemical binding]; other site 644966000299 Cell division inhibitor SulA; Region: SulA; cl01880 644966000300 stage II sporulation protein E; Region: spore_II_E; TIGR02865 644966000301 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 644966000302 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 644966000303 Ligand Binding Site [chemical binding]; other site 644966000304 FtsH Extracellular; Region: FtsH_ext; pfam06480 644966000305 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 644966000306 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966000307 Walker A motif; other site 644966000308 ATP binding site [chemical binding]; other site 644966000309 Walker B motif; other site 644966000310 arginine finger; other site 644966000311 Peptidase family M41; Region: Peptidase_M41; pfam01434 644966000312 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 644966000313 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 644966000314 active site 644966000315 NTP binding site [chemical binding]; other site 644966000316 metal binding triad [ion binding]; metal-binding site 644966000317 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 644966000318 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 644966000319 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 644966000320 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 644966000321 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 644966000322 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 644966000323 active site 644966000324 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 644966000325 active sites [active] 644966000326 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 644966000327 tetramer interface [polypeptide binding]; other site 644966000328 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 644966000329 dihydropteroate synthase; Region: DHPS; TIGR01496 644966000330 substrate binding pocket [chemical binding]; other site 644966000331 dimer interface [polypeptide binding]; other site 644966000332 inhibitor binding site; inhibition site 644966000333 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 644966000334 homooctamer interface [polypeptide binding]; other site 644966000335 active site 644966000336 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 644966000337 catalytic center binding site [active] 644966000338 ATP binding site [chemical binding]; other site 644966000339 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 644966000340 putative active site pocket [active] 644966000341 cleavage site 644966000342 DmpA/OAT superfamily; composed of L-aminopeptidase D-amidase/D-esterase (DmpA), ornithine acetyltransferase (OAT) and similar proteins. DmpA is an aminopeptidase that releases N-terminal D and L amino acids from peptide substrates. This group represents...; Region: DmpA_OAT; cl00603 644966000343 cleavage site 644966000344 Type III pantothenate kinase; Region: Pan_kinase; cl09130 644966000345 Bifunctional nuclease; Region: DNase-RNase; cl00553 644966000346 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 644966000347 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 644966000348 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 644966000349 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 644966000350 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 644966000351 dimer interface [polypeptide binding]; other site 644966000352 putative anticodon binding site; other site 644966000353 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 644966000354 motif 1; other site 644966000355 active site 644966000356 motif 2; other site 644966000357 motif 3; other site 644966000358 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 644966000359 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 644966000360 ATP-binding site [chemical binding]; other site 644966000361 Sugar specificity; other site 644966000362 Pyrimidine base specificity; other site 644966000363 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 644966000364 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 644966000365 active site 644966000366 catalytic residues [active] 644966000367 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 644966000368 active site 644966000369 intersubunit interactions; other site 644966000370 catalytic residue [active] 644966000371 transcription termination factor Rho; Provisional; Region: rho; PRK09376 644966000372 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 644966000373 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 644966000374 RNA binding site [nucleotide binding]; other site 644966000375 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 644966000376 multimer interface [polypeptide binding]; other site 644966000377 Walker A motif; other site 644966000378 ATP binding site [chemical binding]; other site 644966000379 Walker B motif; other site 644966000380 Peptidase family M23; Region: Peptidase_M23; pfam01551 644966000381 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 644966000382 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 644966000383 peptide chain release factor 1; Validated; Region: prfA; PRK00591 644966000384 RF-1 domain; Region: RF-1; cl02875 644966000385 RF-1 domain; Region: RF-1; cl02875 644966000386 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 644966000387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966000388 S-adenosylmethionine binding site [chemical binding]; other site 644966000389 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 644966000390 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 644966000391 Low molecular weight phosphatase family; Region: LMWPc; cl00105 644966000392 active site 644966000393 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 644966000394 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 644966000395 Mg++ binding site [ion binding]; other site 644966000396 putative catalytic motif [active] 644966000397 substrate binding site [chemical binding]; other site 644966000398 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 644966000399 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 644966000400 active site 644966000401 homodimer interface [polypeptide binding]; other site 644966000402 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 644966000403 ATP synthase A chain; Region: ATP-synt_A; cl00413 644966000404 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 644966000405 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 644966000406 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 644966000407 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 644966000408 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 644966000409 beta subunit interaction interface [polypeptide binding]; other site 644966000410 Walker A motif; other site 644966000411 ATP binding site [chemical binding]; other site 644966000412 Walker B motif; other site 644966000413 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644966000414 ATP synthase; Region: ATP-synt; cl00365 644966000415 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 644966000416 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 644966000417 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 644966000418 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 644966000419 alpha subunit interaction interface [polypeptide binding]; other site 644966000420 Walker A motif; other site 644966000421 ATP binding site [chemical binding]; other site 644966000422 Walker B motif; other site 644966000423 inhibitor binding site; inhibition site 644966000424 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 644966000425 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 644966000426 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 644966000427 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 644966000428 hinge; other site 644966000429 active site 644966000430 stage II sporulation protein D; Region: spore_II_D; TIGR02870 644966000431 Stage II sporulation protein; Region: SpoIID; pfam08486 644966000432 Peptidase family M23; Region: Peptidase_M23; pfam01551 644966000433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 644966000434 rod shape-determining protein MreB; Provisional; Region: PRK13927 644966000435 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 644966000436 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 644966000437 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 644966000438 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 644966000439 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 644966000440 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 644966000441 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 644966000442 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 644966000443 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 644966000444 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 644966000445 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644966000446 RNA binding site [nucleotide binding]; other site 644966000447 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 644966000448 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644966000449 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644966000450 active site 644966000451 motif I; other site 644966000452 motif II; other site 644966000453 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644966000454 flagellin; Provisional; Region: PRK12806 644966000455 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 644966000456 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 644966000457 FlaG protein; Region: FlaG; cl00591 644966000458 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 644966000459 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 644966000460 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 644966000461 Flagellar protein FliS; Region: FliS; cl00654 644966000462 S-adenosylmethionine synthetase; Validated; Region: PRK05250 644966000463 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 644966000464 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 644966000465 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 644966000466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644966000467 active site 644966000468 GAF domain; Region: GAF; cl15785 644966000469 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644966000470 metal binding site [ion binding]; metal-binding site 644966000471 active site 644966000472 I-site; other site 644966000473 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 644966000474 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 644966000475 FlgN protein; Region: FlgN; cl09176 644966000476 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 644966000477 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 644966000478 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 644966000479 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 644966000480 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 644966000481 This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800 644966000482 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 644966000483 active site 644966000484 substrate binding site [chemical binding]; other site 644966000485 metal binding site [ion binding]; metal-binding site 644966000486 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 644966000487 30S subunit binding site; other site 644966000488 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644966000489 Zn2+ binding site [ion binding]; other site 644966000490 Mg2+ binding site [ion binding]; other site 644966000491 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 644966000492 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966000493 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 644966000494 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966000495 nucleotide binding region [chemical binding]; other site 644966000496 peptide chain release factor 2; Validated; Region: prfB; PRK00578 644966000497 RF-1 domain; Region: RF-1; cl02875 644966000498 RF-1 domain; Region: RF-1; cl02875 644966000499 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 644966000500 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966000501 Walker A/P-loop; other site 644966000502 ATP binding site [chemical binding]; other site 644966000503 Q-loop/lid; other site 644966000504 ABC transporter signature motif; other site 644966000505 Walker B; other site 644966000506 D-loop; other site 644966000507 H-loop/switch region; other site 644966000508 FtsX-like permease family; Region: FtsX; cl15850 644966000509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 644966000510 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 644966000511 Peptidase family M23; Region: Peptidase_M23; pfam01551 644966000512 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 644966000513 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 644966000514 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 644966000515 protein binding site [polypeptide binding]; other site 644966000516 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 644966000517 Catalytic dyad [active] 644966000518 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644966000519 excinuclease ABC subunit B; Provisional; Region: PRK05298 644966000520 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966000521 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644966000522 nucleotide binding region [chemical binding]; other site 644966000523 ATP-binding site [chemical binding]; other site 644966000524 Ultra-violet resistance protein B; Region: UvrB; pfam12344 644966000525 UvrB/uvrC motif; Region: UVR; pfam02151 644966000526 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 644966000527 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 644966000528 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 644966000529 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 644966000530 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 644966000531 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644966000532 Radical SAM superfamily; Region: Radical_SAM; pfam04055 644966000533 FeS/SAM binding site; other site 644966000534 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 644966000535 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 644966000536 GIY-YIG motif/motif A; other site 644966000537 active site 644966000538 catalytic site [active] 644966000539 putative DNA binding site [nucleotide binding]; other site 644966000540 metal binding site [ion binding]; metal-binding site 644966000541 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 644966000542 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 644966000543 Hef nuclease; Provisional; Region: PRK13766 644966000544 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644966000545 TPP binding site [chemical binding]; other site 644966000546 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 644966000547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966000548 Membrane protein of unknown function; Region: DUF360; cl00850 644966000549 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 644966000550 trimer interface [polypeptide binding]; other site 644966000551 active site 644966000552 dimer interface [polypeptide binding]; other site 644966000553 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 644966000554 ADP binding site [chemical binding]; other site 644966000555 magnesium binding site [ion binding]; other site 644966000556 putative shikimate binding site; other site 644966000557 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 644966000558 active site 644966000559 dimer interface [polypeptide binding]; other site 644966000560 metal binding site [ion binding]; metal-binding site 644966000561 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 644966000562 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cl00323 644966000563 FMN-binding site [chemical binding]; other site 644966000564 active site 644966000565 Tetramer interface [polypeptide binding]; other site 644966000566 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 644966000567 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 644966000568 NAD(P) binding site [chemical binding]; other site 644966000569 shikimate binding site; other site 644966000570 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 644966000571 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 644966000572 hinge; other site 644966000573 active site 644966000574 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966000575 Prephenate dehydrogenase; Region: PDH; pfam02153 644966000576 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 644966000577 NeuB family; Region: NeuB; cl00496 644966000578 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 644966000579 homotrimer interaction site [polypeptide binding]; other site 644966000580 active site 644966000581 Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640 644966000582 RNA binding site [nucleotide binding]; other site 644966000583 hexamer interface [polypeptide binding]; other site 644966000584 Histidine-zinc binding site [chemical binding]; other site 644966000585 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 644966000586 MgtE intracellular N domain; Region: MgtE_N; cl15244 644966000587 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 644966000588 Divalent cation transporter; Region: MgtE; cl00786 644966000589 glyoxylate reductase; Reviewed; Region: PRK13243 644966000590 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966000591 Fic/DOC family; Region: Fic; cl00960 644966000592 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966000593 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 644966000594 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 644966000595 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 644966000596 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 644966000597 phosphate binding site [ion binding]; other site 644966000598 putative substrate binding pocket [chemical binding]; other site 644966000599 dimer interface [polypeptide binding]; other site 644966000600 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 644966000601 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 644966000602 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644966000603 substrate binding pocket [chemical binding]; other site 644966000604 chain length determination region; other site 644966000605 substrate-Mg2+ binding site; other site 644966000606 catalytic residues [active] 644966000607 aspartate-rich region 1; other site 644966000608 active site lid residues [active] 644966000609 aspartate-rich region 2; other site 644966000610 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 644966000611 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 644966000612 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966000613 Uncharacterized conserved protein [Function unknown]; Region: COG1624 644966000614 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 644966000615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 644966000616 YbbR-like protein; Region: YbbR; pfam07949 644966000617 YbbR-like protein; Region: YbbR; pfam07949 644966000618 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 644966000619 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 644966000620 active site 644966000621 metal binding site [ion binding]; metal-binding site 644966000622 substrate binding site [chemical binding]; other site 644966000623 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 644966000624 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 644966000625 glutaminase active site [active] 644966000626 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 644966000627 dimer interface [polypeptide binding]; other site 644966000628 active site 644966000629 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 644966000630 dimer interface [polypeptide binding]; other site 644966000631 active site 644966000632 Chromate transporter; Region: Chromate_transp; pfam02417 644966000633 Chromate transporter; Region: Chromate_transp; pfam02417 644966000634 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644966000635 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644966000636 DNA-binding site [nucleotide binding]; DNA binding site 644966000637 UTRA domain; Region: UTRA; cl01230 644966000638 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 644966000639 substrate binding site [chemical binding]; other site 644966000640 dimer interface [polypeptide binding]; other site 644966000641 ATP binding site [chemical binding]; other site 644966000642 nuc_hydro_CeIAG: Nucleoside hydrolases similar to the inosine-adenosine-guanosine-preferring nucleoside hydrolase from Caenorhabditis elegans. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_CeIAG; cd02649 644966000643 active site 644966000644 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 644966000645 intersubunit interface [polypeptide binding]; other site 644966000646 active site 644966000647 catalytic residue [active] 644966000648 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966000649 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 644966000650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966000651 S-adenosylmethionine binding site [chemical binding]; other site 644966000652 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 644966000653 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644966000654 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 644966000655 catalytic residues [active] 644966000656 Domain of unknown function DUF302; Region: DUF302; cl01364 644966000657 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644966000658 dimerization interface [polypeptide binding]; other site 644966000659 putative DNA binding site [nucleotide binding]; other site 644966000660 putative Zn2+ binding site [ion binding]; other site 644966000661 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644966000662 active site residue [active] 644966000663 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 644966000664 active site residue [active] 644966000665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966000666 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 644966000667 CPxP motif; other site 644966000668 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644966000669 active site residue [active] 644966000670 DsrE/DsrF-like family; Region: DrsE; cl00672 644966000671 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 644966000672 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966000673 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 644966000674 D-pathway; other site 644966000675 Low-spin heme binding site [chemical binding]; other site 644966000676 Putative water exit pathway; other site 644966000677 Binuclear center (active site) [active] 644966000678 K-pathway; other site 644966000679 Putative proton exit pathway; other site 644966000680 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 644966000681 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 644966000682 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 644966000683 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 644966000684 putative substrate binding site [chemical binding]; other site 644966000685 putative ATP binding site [chemical binding]; other site 644966000686 alanine racemase; Reviewed; Region: alr; PRK00053 644966000687 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 644966000688 active site 644966000689 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644966000690 dimer interface [polypeptide binding]; other site 644966000691 substrate binding site [chemical binding]; other site 644966000692 catalytic residues [active] 644966000693 PemK-like protein; Region: PemK; cl00995 644966000694 L-asparaginase II; Region: Asparaginase_II; cl01842 644966000695 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 644966000696 Fe-S cluster binding site [ion binding]; other site 644966000697 active site 644966000698 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 644966000699 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 644966000700 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 644966000701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644966000702 Coenzyme A binding pocket [chemical binding]; other site 644966000703 UGMP family protein; Validated; Region: PRK09604 644966000704 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 644966000705 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 644966000706 trimer interface [polypeptide binding]; other site 644966000707 active site 644966000708 substrate binding site [chemical binding]; other site 644966000709 CoA binding site [chemical binding]; other site 644966000710 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 644966000711 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644966000712 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644966000713 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644966000714 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 644966000715 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 644966000716 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 644966000717 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 644966000718 active site 644966000719 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 644966000720 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644966000721 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644966000722 acetyl-CoA acetyltransferase; Provisional; Region: PRK08235 644966000723 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 644966000724 dimer interface [polypeptide binding]; other site 644966000725 active site 644966000726 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 644966000727 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 644966000728 dimer interface [polypeptide binding]; other site 644966000729 putative functional site; other site 644966000730 putative MPT binding site; other site 644966000731 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 644966000732 trimer interface [polypeptide binding]; other site 644966000733 dimer interface [polypeptide binding]; other site 644966000734 putative active site [active] 644966000735 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 644966000736 MPT binding site; other site 644966000737 trimer interface [polypeptide binding]; other site 644966000738 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 644966000739 oligomerisation interface [polypeptide binding]; other site 644966000740 mobile loop; other site 644966000741 roof hairpin; other site 644966000742 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 644966000743 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 644966000744 ring oligomerisation interface [polypeptide binding]; other site 644966000745 ATP/Mg binding site [chemical binding]; other site 644966000746 stacking interactions; other site 644966000747 hinge regions; other site 644966000748 PIN domain of the Pyrobaculum aerophilum Pae0151 and Pae2754 proteins and homologs; Region: PIN_Pae0151; cd09873 644966000749 putative active site [active] 644966000750 homotetrameric interface [polypeptide binding]; other site 644966000751 metal binding site [ion binding]; metal-binding site 644966000752 GMP synthase; Reviewed; Region: guaA; PRK00074 644966000753 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 644966000754 AMP/PPi binding site [chemical binding]; other site 644966000755 candidate oxyanion hole; other site 644966000756 catalytic triad [active] 644966000757 potential glutamine specificity residues [chemical binding]; other site 644966000758 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 644966000759 ATP Binding subdomain [chemical binding]; other site 644966000760 Ligand Binding sites [chemical binding]; other site 644966000761 Dimerization subdomain; other site 644966000762 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644966000763 Zn2+ binding site [ion binding]; other site 644966000764 Mg2+ binding site [ion binding]; other site 644966000765 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 644966000766 GAF domain; Region: GAF; cl15785 644966000767 sensory histidine kinase AtoS; Provisional; Region: PRK11360 644966000768 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966000769 phosphorylation site [posttranslational modification] 644966000770 dimer interface [polypeptide binding]; other site 644966000771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966000772 ATP binding site [chemical binding]; other site 644966000773 Mg2+ binding site [ion binding]; other site 644966000774 G-X-G motif; other site 644966000775 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 644966000776 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966000777 Family description; Region: UvrD_C_2; cl15862 644966000778 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 644966000779 Ligase N family; Region: LIGANc; smart00532 644966000780 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 644966000781 nucleotide binding pocket [chemical binding]; other site 644966000782 K-X-D-G motif; other site 644966000783 catalytic site [active] 644966000784 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 644966000785 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 644966000786 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 644966000787 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 644966000788 Dimer interface [polypeptide binding]; other site 644966000789 BRCT sequence motif; other site 644966000790 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644966000791 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644966000792 peptide binding site [polypeptide binding]; other site 644966000793 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966000794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966000795 dimer interface [polypeptide binding]; other site 644966000796 conserved gate region; other site 644966000797 putative PBP binding loops; other site 644966000798 ABC-ATPase subunit interface; other site 644966000799 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644966000800 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644966000801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966000802 dimer interface [polypeptide binding]; other site 644966000803 conserved gate region; other site 644966000804 putative PBP binding loops; other site 644966000805 ABC-ATPase subunit interface; other site 644966000806 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966000807 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966000808 Walker A/P-loop; other site 644966000809 ATP binding site [chemical binding]; other site 644966000810 Q-loop/lid; other site 644966000811 ABC transporter signature motif; other site 644966000812 Walker B; other site 644966000813 D-loop; other site 644966000814 H-loop/switch region; other site 644966000815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966000816 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 644966000817 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966000818 Walker A/P-loop; other site 644966000819 ATP binding site [chemical binding]; other site 644966000820 Q-loop/lid; other site 644966000821 ABC transporter signature motif; other site 644966000822 Walker B; other site 644966000823 D-loop; other site 644966000824 H-loop/switch region; other site 644966000825 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966000826 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 644966000827 peptide binding site [polypeptide binding]; other site 644966000828 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966000829 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966000830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966000831 dimer interface [polypeptide binding]; other site 644966000832 conserved gate region; other site 644966000833 putative PBP binding loops; other site 644966000834 ABC-ATPase subunit interface; other site 644966000835 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644966000836 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644966000837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966000838 dimer interface [polypeptide binding]; other site 644966000839 conserved gate region; other site 644966000840 putative PBP binding loops; other site 644966000841 ABC-ATPase subunit interface; other site 644966000842 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966000843 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966000844 Walker A/P-loop; other site 644966000845 ATP binding site [chemical binding]; other site 644966000846 Q-loop/lid; other site 644966000847 ABC transporter signature motif; other site 644966000848 Walker B; other site 644966000849 D-loop; other site 644966000850 H-loop/switch region; other site 644966000851 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966000852 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 644966000853 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966000854 Walker A/P-loop; other site 644966000855 ATP binding site [chemical binding]; other site 644966000856 Q-loop/lid; other site 644966000857 ABC transporter signature motif; other site 644966000858 Walker B; other site 644966000859 D-loop; other site 644966000860 H-loop/switch region; other site 644966000861 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966000862 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 644966000863 hypothetical protein; Provisional; Region: PRK06446 644966000864 metal binding site [ion binding]; metal-binding site 644966000865 dimer interface [polypeptide binding]; other site 644966000866 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 644966000867 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 644966000868 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 644966000869 active site 644966000870 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 644966000871 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 644966000872 Amidase; Region: Amidase; cl11426 644966000873 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 644966000874 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 644966000875 GatB domain; Region: GatB_Yqey; cl11497 644966000876 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 644966000877 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 644966000878 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 644966000879 Protein export membrane protein; Region: SecD_SecF; cl14618 644966000880 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 644966000881 phosphate binding site [ion binding]; other site 644966000882 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 644966000883 homodimer interface [polypeptide binding]; other site 644966000884 substrate-cofactor binding pocket; other site 644966000885 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966000886 catalytic residue [active] 644966000887 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 644966000888 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644966000889 active site 644966000890 metal binding site [ion binding]; metal-binding site 644966000891 homotetramer interface [polypeptide binding]; other site 644966000892 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 644966000893 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966000894 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 644966000895 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 644966000896 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 644966000897 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 644966000898 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 644966000899 NADH dehydrogenase; Region: NADHdh; cl00469 644966000900 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 644966000901 4Fe-4S binding domain; Region: Fer4; cl02805 644966000902 4Fe-4S binding domain; Region: Fer4; cl02805 644966000903 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 644966000904 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 644966000905 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 644966000906 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 644966000907 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 644966000908 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 644966000909 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 644966000910 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 644966000911 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 644966000912 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 644966000913 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644966000914 Ligand Binding Site [chemical binding]; other site 644966000915 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 644966000916 Cytochrome c; Region: Cytochrom_C; cl11414 644966000917 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 644966000918 Cytochrome c; Region: Cytochrom_C; cl11414 644966000919 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 644966000920 iron-sulfur cluster [ion binding]; other site 644966000921 [2Fe-2S] cluster binding site [ion binding]; other site 644966000922 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 644966000923 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 644966000924 heme bH binding site [chemical binding]; other site 644966000925 intrachain domain interface; other site 644966000926 Qi binding site; other site 644966000927 heme bL binding site [chemical binding]; other site 644966000928 interchain domain interface [polypeptide binding]; other site 644966000929 Qo binding site; other site 644966000930 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 644966000931 ATP cone domain; Region: ATP-cone; pfam03477 644966000932 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 644966000933 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 644966000934 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 644966000935 active site 644966000936 dimer interface [polypeptide binding]; other site 644966000937 effector binding site; other site 644966000938 TSCPD domain; Region: TSCPD; cl14834 644966000939 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 644966000940 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644966000941 FOG: CBS domain [General function prediction only]; Region: COG0517 644966000942 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 644966000943 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 644966000944 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 644966000945 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644966000946 active site 644966000947 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 644966000948 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 644966000949 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 644966000950 MoxR-like ATPases [General function prediction only]; Region: COG0714 644966000951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966000952 Walker A motif; other site 644966000953 ATP binding site [chemical binding]; other site 644966000954 Walker B motif; other site 644966000955 arginine finger; other site 644966000956 tellurite resistance protein TehB; Provisional; Region: PRK12335 644966000957 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966000958 S-adenosylmethionine binding site [chemical binding]; other site 644966000959 Domain of unknown function (DUF309); Region: DUF309; cl00667 644966000960 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 644966000961 catalytic triad [active] 644966000962 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 644966000963 DNA binding residues [nucleotide binding] 644966000964 S-layer homology domain; Region: SLH; pfam00395 644966000965 S-layer homology domain; Region: SLH; pfam00395 644966000966 S-layer homology domain; Region: SLH; pfam00395 644966000967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 644966000968 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644966000969 DNA binding residues [nucleotide binding] 644966000970 Integrase core domain; Region: rve; cl01316 644966000971 Integrase core domain; Region: rve_3; cl15866 644966000972 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644966000973 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 644966000974 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 644966000975 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 644966000976 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 644966000977 stage II sporulation protein D; Region: spore_II_D; TIGR02870 644966000978 Stage II sporulation protein; Region: SpoIID; pfam08486 644966000979 stage II sporulation protein P; Region: spore_II_P; TIGR02867 644966000980 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 644966000981 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966000982 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 644966000983 aspartate aminotransferase; Provisional; Region: PRK05764 644966000984 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644966000985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966000986 homodimer interface [polypeptide binding]; other site 644966000987 catalytic residue [active] 644966000988 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01710 644966000989 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644966000990 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644966000991 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 644966000992 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 644966000993 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644966000994 active site 644966000995 DNA binding site [nucleotide binding] 644966000996 Int/Topo IB signature motif; other site 644966000997 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966000998 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966000999 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 644966001000 putative active site [active] 644966001001 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 644966001002 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966001003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 644966001004 Transposase; Region: DDE_Tnp_ISL3; pfam01610 644966001005 methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463 644966001006 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 644966001007 substrate binding site [chemical binding]; other site 644966001008 active site 644966001009 Disulphide isomerase; Region: Disulph_isomer; cl05813 644966001010 OsmC-like protein; Region: OsmC; cl00767 644966001011 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 644966001012 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 644966001013 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 644966001014 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 644966001015 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 644966001016 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 644966001017 tetramer interfaces [polypeptide binding]; other site 644966001018 binuclear metal-binding site [ion binding]; other site 644966001019 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 644966001020 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 644966001021 oligomerization interface [polypeptide binding]; other site 644966001022 active site 644966001023 metal binding site [ion binding]; metal-binding site 644966001024 pantoate--beta-alanine ligase; Region: panC; TIGR00018 644966001025 Pantoate-beta-alanine ligase; Region: PanC; cd00560 644966001026 active site 644966001027 ATP-binding site [chemical binding]; other site 644966001028 pantoate-binding site; other site 644966001029 HXXH motif; other site 644966001030 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 644966001031 Uncharacterized conserved protein [Function unknown]; Region: COG2718 644966001032 SpoVR like protein; Region: SpoVR; pfam04293 644966001033 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 644966001034 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 644966001035 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001036 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 644966001037 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 644966001038 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 644966001039 active site 644966001040 ADP/pyrophosphate binding site [chemical binding]; other site 644966001041 dimerization interface [polypeptide binding]; other site 644966001042 allosteric effector site; other site 644966001043 fructose-1,6-bisphosphate binding site; other site 644966001044 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 644966001045 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 644966001046 domain interfaces; other site 644966001047 active site 644966001048 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 644966001049 antiporter inner membrane protein; Provisional; Region: PRK11670 644966001050 Domain of unknown function DUF59; Region: DUF59; cl00941 644966001051 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 644966001052 Walker A motif; other site 644966001053 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001054 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966001055 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644966001056 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966001057 aspartate kinase; Reviewed; Region: PRK06635 644966001058 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 644966001059 putative catalytic residues [active] 644966001060 putative nucleotide binding site [chemical binding]; other site 644966001061 putative aspartate binding site [chemical binding]; other site 644966001062 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 644966001063 putative allosteric regulatory site; other site 644966001064 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 644966001065 putative allosteric regulatory residue; other site 644966001066 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 644966001067 putative active site [active] 644966001068 nucleotide binding site [chemical binding]; other site 644966001069 nudix motif; other site 644966001070 putative metal binding site [ion binding]; other site 644966001071 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 644966001072 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 644966001073 metal binding site [ion binding]; metal-binding site 644966001074 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 644966001075 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 644966001076 active site 644966001077 metal binding site [ion binding]; metal-binding site 644966001078 Thymidylate synthase complementing protein; Region: Thy1; cl03630 644966001079 Thymidylate synthase complementing protein; Region: Thy1; cl03630 644966001080 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 644966001081 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 644966001082 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 644966001083 NAD binding site [chemical binding]; other site 644966001084 homodimer interface [polypeptide binding]; other site 644966001085 homotetramer interface [polypeptide binding]; other site 644966001086 active site 644966001087 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 644966001088 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 644966001089 dimer interface [polypeptide binding]; other site 644966001090 active site 644966001091 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644966001092 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644966001093 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 644966001094 AMP-binding enzyme; Region: AMP-binding; cl15778 644966001095 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966001096 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966001097 Predicted esterase [General function prediction only]; Region: COG0627 644966001098 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644966001099 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644966001100 NAD(P) binding site [chemical binding]; other site 644966001101 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644966001102 NAD(P) binding site [chemical binding]; other site 644966001103 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644966001104 Cupin domain; Region: Cupin_2; cl09118 644966001105 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 644966001106 UbiA prenyltransferase family; Region: UbiA; cl00337 644966001107 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 644966001108 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966001109 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 644966001110 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 644966001111 D-pathway; other site 644966001112 Low-spin heme binding site [chemical binding]; other site 644966001113 Putative water exit pathway; other site 644966001114 Binuclear center (active site) [active] 644966001115 K-pathway; other site 644966001116 Putative proton exit pathway; other site 644966001117 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 644966001118 Subunit I/III interface [polypeptide binding]; other site 644966001119 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 644966001120 Subunit I/III interface [polypeptide binding]; other site 644966001121 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 644966001122 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 644966001123 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 644966001124 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 644966001125 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966001126 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966001127 DNA binding residues [nucleotide binding] 644966001128 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 644966001129 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966001130 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966001131 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966001132 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966001133 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 644966001134 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 644966001135 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966001136 5'-3' exonuclease; Region: 53EXOc; smart00475 644966001137 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 644966001138 active site 644966001139 metal binding site 1 [ion binding]; metal-binding site 644966001140 putative 5' ssDNA interaction site; other site 644966001141 metal binding site 3; metal-binding site 644966001142 metal binding site 2 [ion binding]; metal-binding site 644966001143 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 644966001144 putative DNA binding site [nucleotide binding]; other site 644966001145 putative metal binding site [ion binding]; other site 644966001146 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 644966001147 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 644966001148 active site 644966001149 DNA binding site [nucleotide binding] 644966001150 catalytic site [active] 644966001151 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 644966001152 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 644966001153 catalytic residue [active] 644966001154 H2TH interface [polypeptide binding]; other site 644966001155 putative catalytic residues [active] 644966001156 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 644966001157 DNA binding site [nucleotide binding] 644966001158 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 644966001159 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644966001160 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001161 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 644966001162 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 644966001163 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 644966001164 dephospho-CoA kinase; Region: TIGR00152 644966001165 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 644966001166 CoA-binding site [chemical binding]; other site 644966001167 ATP-binding [chemical binding]; other site 644966001168 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 644966001169 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644966001170 catalytic residue [active] 644966001171 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 644966001172 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 644966001173 dihydropteroate synthase; Region: DHPS; TIGR01496 644966001174 substrate binding pocket [chemical binding]; other site 644966001175 dimer interface [polypeptide binding]; other site 644966001176 inhibitor binding site; inhibition site 644966001177 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 644966001178 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001179 NAD(P) binding site [chemical binding]; other site 644966001180 active site 644966001181 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 644966001182 active site 644966001183 Glyco_18 domain; Region: Glyco_18; smart00636 644966001184 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644966001185 active site 644966001186 metal binding site [ion binding]; metal-binding site 644966001187 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 644966001188 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644966001189 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 644966001190 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966001191 active site 644966001192 phosphorylation site [posttranslational modification] 644966001193 intermolecular recognition site; other site 644966001194 dimerization interface [polypeptide binding]; other site 644966001195 LytTr DNA-binding domain; Region: LytTR; cl04498 644966001196 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 644966001197 Histidine kinase; Region: His_kinase; pfam06580 644966001198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966001199 ATP binding site [chemical binding]; other site 644966001200 Mg2+ binding site [ion binding]; other site 644966001201 G-X-G motif; other site 644966001202 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 644966001203 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 644966001204 Na binding site [ion binding]; other site 644966001205 Domain of unknown function (DUF4212); Region: DUF4212; cl01781 644966001206 acetyl-CoA synthetase; Provisional; Region: PRK00174 644966001207 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 644966001208 AMP-binding enzyme; Region: AMP-binding; cl15778 644966001209 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966001210 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 644966001211 RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394 644966001212 bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674 644966001213 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 644966001214 The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637 644966001215 dimer interface [polypeptide binding]; other site 644966001216 active site 644966001217 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644966001218 intersubunit interface [polypeptide binding]; other site 644966001219 Thiamine pyrophosphokinase; Region: TPK; cd07995 644966001220 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 644966001221 active site 644966001222 dimerization interface [polypeptide binding]; other site 644966001223 thiamine binding site [chemical binding]; other site 644966001224 Bacterial SH3 domain; Region: SH3_3; cl02551 644966001225 manganese transport transcriptional regulator; Provisional; Region: PRK03902 644966001226 Helix-turn-helix domains; Region: HTH; cl00088 644966001227 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 644966001228 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966001229 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 644966001230 metal binding site [ion binding]; metal-binding site 644966001231 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 644966001232 Zn binding site [ion binding]; other site 644966001233 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 644966001234 Zn binding site [ion binding]; other site 644966001235 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966001236 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644966001237 hypothetical protein; Provisional; Region: PRK06851 644966001238 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001239 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001240 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 644966001241 DNA binding residues [nucleotide binding] 644966001242 glutamine synthetase, type I; Region: GlnA; TIGR00653 644966001243 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 644966001244 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 644966001245 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 644966001246 catalytic residues [active] 644966001247 Uncharacterized ACR, COG1430; Region: DUF192; cl00627 644966001248 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 644966001249 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 644966001250 DXD motif; other site 644966001251 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644966001252 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 644966001253 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001254 Walker A/P-loop; other site 644966001255 ATP binding site [chemical binding]; other site 644966001256 Q-loop/lid; other site 644966001257 ABC transporter signature motif; other site 644966001258 Walker B; other site 644966001259 D-loop; other site 644966001260 H-loop/switch region; other site 644966001261 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 644966001262 putative hydrophobic ligand binding site [chemical binding]; other site 644966001263 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644966001264 active site 644966001265 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 644966001266 Cl- selectivity filter; other site 644966001267 Cl- binding residues [ion binding]; other site 644966001268 pore gating glutamate residue; other site 644966001269 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 644966001270 FOG: CBS domain [General function prediction only]; Region: COG0517 644966001271 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc; cd04612 644966001272 hypothetical protein; Provisional; Region: PRK08185 644966001273 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 644966001274 intersubunit interface [polypeptide binding]; other site 644966001275 active site 644966001276 zinc binding site [ion binding]; other site 644966001277 Na+ binding site [ion binding]; other site 644966001278 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 644966001279 putative active site [active] 644966001280 GAF domain; Region: GAF; cl15785 644966001281 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 644966001282 intracellular protease, PfpI family; Region: PfpI; TIGR01382 644966001283 proposed catalytic triad [active] 644966001284 conserved cys residue [active] 644966001285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966001286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966001287 ABC-ATPase subunit interface; other site 644966001288 putative PBP binding loops; other site 644966001289 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 644966001290 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966001291 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 644966001292 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 644966001293 NodB motif; other site 644966001294 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 644966001295 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 644966001296 Walker A/P-loop; other site 644966001297 ATP binding site [chemical binding]; other site 644966001298 Q-loop/lid; other site 644966001299 ABC transporter signature motif; other site 644966001300 Walker B; other site 644966001301 D-loop; other site 644966001302 H-loop/switch region; other site 644966001303 ABC-2 type transporter; Region: ABC2_membrane; cl11417 644966001304 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644966001305 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 644966001306 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 644966001307 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 644966001308 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644966001309 Helix-turn-helix domains; Region: HTH; cl00088 644966001310 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 644966001311 Ligand binding site [chemical binding]; other site 644966001312 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 644966001313 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 644966001314 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 644966001315 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 644966001316 4Fe-4S binding domain; Region: Fer4; cl02805 644966001317 Cysteine-rich domain; Region: CCG; pfam02754 644966001318 Cysteine-rich domain; Region: CCG; pfam02754 644966001319 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 644966001320 AMP-binding enzyme; Region: AMP-binding; cl15778 644966001321 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966001322 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 644966001323 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 644966001324 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 644966001325 N-acylamino acid racemase (NAAAR), an octameric enzyme that catalyzes the racemization of N-acylamino acids. NAAARs act on a broad range of N-acylamino acids rather than amino acids. Enantiopure amino acids are of industrial interest as chiral building...; Region: NAAAR; cd03317 644966001326 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 644966001327 active site 644966001328 octamer interface [polypeptide binding]; other site 644966001329 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 644966001330 CoenzymeA binding site [chemical binding]; other site 644966001331 subunit interaction site [polypeptide binding]; other site 644966001332 PHB binding site; other site 644966001333 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 644966001334 NMT1-like family; Region: NMT1_2; cl15260 644966001335 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 644966001336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966001337 dimer interface [polypeptide binding]; other site 644966001338 conserved gate region; other site 644966001339 putative PBP binding loops; other site 644966001340 ABC-ATPase subunit interface; other site 644966001341 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 644966001342 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 644966001343 Walker A/P-loop; other site 644966001344 ATP binding site [chemical binding]; other site 644966001345 Q-loop/lid; other site 644966001346 ABC transporter signature motif; other site 644966001347 Walker B; other site 644966001348 D-loop; other site 644966001349 H-loop/switch region; other site 644966001350 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 644966001351 Cation efflux family; Region: Cation_efflux; cl00316 644966001352 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 644966001353 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 644966001354 TRAM domain; Region: TRAM; cl01282 644966001355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966001356 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 644966001357 Chlorite dismutase; Region: Chlor_dismutase; cl01280 644966001358 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 644966001359 Amidase; Region: Amidase; cl11426 644966001360 Sulfatase; Region: Sulfatase; cl10460 644966001361 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 644966001362 Ligand binding site; other site 644966001363 Putative Catalytic site; other site 644966001364 DXD motif; other site 644966001365 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966001366 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966001367 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 644966001368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966001369 dimer interface [polypeptide binding]; other site 644966001370 conserved gate region; other site 644966001371 putative PBP binding loops; other site 644966001372 ABC-ATPase subunit interface; other site 644966001373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966001374 dimer interface [polypeptide binding]; other site 644966001375 conserved gate region; other site 644966001376 putative PBP binding loops; other site 644966001377 ABC-ATPase subunit interface; other site 644966001378 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 644966001379 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001380 Walker A/P-loop; other site 644966001381 ATP binding site [chemical binding]; other site 644966001382 Q-loop/lid; other site 644966001383 ABC transporter signature motif; other site 644966001384 Walker B; other site 644966001385 D-loop; other site 644966001386 H-loop/switch region; other site 644966001387 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 644966001388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001389 NAD(P) binding site [chemical binding]; other site 644966001390 active site 644966001391 Predicted ATPase [General function prediction only]; Region: COG4637 644966001392 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001393 Walker A/P-loop; other site 644966001394 ATP binding site [chemical binding]; other site 644966001395 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 644966001396 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 644966001397 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 644966001398 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 644966001399 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 644966001400 active site 644966001401 Helix-turn-helix domains; Region: HTH; cl00088 644966001402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966001403 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644966001404 putative substrate translocation pore; other site 644966001405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966001406 MOSC domain; Region: MOSC; pfam03473 644966001407 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644966001408 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 644966001409 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 644966001410 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 644966001411 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966001412 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001413 Walker A/P-loop; other site 644966001414 ATP binding site [chemical binding]; other site 644966001415 ABC transporter; Region: ABC_tran; pfam00005 644966001416 Q-loop/lid; other site 644966001417 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001418 ABC transporter signature motif; other site 644966001419 ABC transporter signature motif; other site 644966001420 Walker B; other site 644966001421 Walker B; other site 644966001422 D-loop; other site 644966001423 D-loop; other site 644966001424 H-loop/switch region; other site 644966001425 VanZ like family; Region: VanZ; cl01971 644966001426 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644966001427 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001428 Walker A/P-loop; other site 644966001429 ATP binding site [chemical binding]; other site 644966001430 Q-loop/lid; other site 644966001431 ABC transporter signature motif; other site 644966001432 Walker B; other site 644966001433 D-loop; other site 644966001434 H-loop/switch region; other site 644966001435 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 644966001436 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 644966001437 homodimer interface [polypeptide binding]; other site 644966001438 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966001439 catalytic residue [active] 644966001440 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 644966001441 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001442 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 644966001443 putative L-serine binding site [chemical binding]; other site 644966001444 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 644966001445 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 644966001446 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644966001447 TM-ABC transporter signature motif; other site 644966001448 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644966001449 TM-ABC transporter signature motif; other site 644966001450 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 644966001451 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 644966001452 Walker A/P-loop; other site 644966001453 ATP binding site [chemical binding]; other site 644966001454 Q-loop/lid; other site 644966001455 ABC transporter signature motif; other site 644966001456 Walker B; other site 644966001457 D-loop; other site 644966001458 H-loop/switch region; other site 644966001459 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 644966001460 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 644966001461 Walker A/P-loop; other site 644966001462 ATP binding site [chemical binding]; other site 644966001463 Q-loop/lid; other site 644966001464 ABC transporter signature motif; other site 644966001465 Walker B; other site 644966001466 D-loop; other site 644966001467 H-loop/switch region; other site 644966001468 enoyl-CoA hydratase; Provisional; Region: PRK07657 644966001469 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966001470 substrate binding site [chemical binding]; other site 644966001471 oxyanion hole (OAH) forming residues; other site 644966001472 trimer interface [polypeptide binding]; other site 644966001473 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 644966001474 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 644966001475 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644966001476 catalytic residue [active] 644966001477 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 644966001478 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 644966001479 active site 644966001480 Zn binding site [ion binding]; other site 644966001481 Domain of unknown function DUF77; Region: DUF77; cl00307 644966001482 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 644966001483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966001484 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001485 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 644966001486 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001487 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001488 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001489 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 644966001490 active site 644966001491 multimer interface [polypeptide binding]; other site 644966001492 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 644966001493 predicted active site [active] 644966001494 catalytic triad [active] 644966001495 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 644966001496 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001497 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 644966001498 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 644966001499 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 644966001500 heterotetramer interface [polypeptide binding]; other site 644966001501 active site pocket [active] 644966001502 cleavage site 644966001503 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 644966001504 feedback inhibition sensing region; other site 644966001505 homohexameric interface [polypeptide binding]; other site 644966001506 nucleotide binding site [chemical binding]; other site 644966001507 N-acetyl-L-glutamate binding site [chemical binding]; other site 644966001508 acetylornithine aminotransferase; Provisional; Region: PRK02627 644966001509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644966001510 inhibitor-cofactor binding pocket; inhibition site 644966001511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966001512 catalytic residue [active] 644966001513 ornithine carbamoyltransferase; Provisional; Region: PRK00779 644966001514 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 644966001515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001516 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 644966001517 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 644966001518 ANP binding site [chemical binding]; other site 644966001519 Substrate Binding Site II [chemical binding]; other site 644966001520 Substrate Binding Site I [chemical binding]; other site 644966001521 MOSC domain; Region: MOSC; pfam03473 644966001522 argininosuccinate lyase; Provisional; Region: PRK00855 644966001523 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 644966001524 active sites [active] 644966001525 tetramer interface [polypeptide binding]; other site 644966001526 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 644966001527 homodimer interface [polypeptide binding]; other site 644966001528 homotetramer interface [polypeptide binding]; other site 644966001529 active site pocket [active] 644966001530 cleavage site 644966001531 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 644966001532 Fe-S cluster binding site [ion binding]; other site 644966001533 DNA binding site [nucleotide binding] 644966001534 active site 644966001535 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 644966001536 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644966001537 catalytic loop [active] 644966001538 iron binding site [ion binding]; other site 644966001539 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 644966001540 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 644966001541 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 644966001542 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 644966001543 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 644966001544 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 644966001545 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 644966001546 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 644966001547 active site 644966001548 homotetramer interface [polypeptide binding]; other site 644966001549 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 644966001550 Tetratricopeptide repeat; Region: TPR_16; pfam13432 644966001551 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644966001552 TPR motif; other site 644966001553 binding surface 644966001554 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966001555 dimer interface [polypeptide binding]; other site 644966001556 conserved gate region; other site 644966001557 ABC-ATPase subunit interface; other site 644966001558 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001559 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644966001560 Walker A/P-loop; other site 644966001561 ATP binding site [chemical binding]; other site 644966001562 Q-loop/lid; other site 644966001563 ABC transporter signature motif; other site 644966001564 Walker B; other site 644966001565 D-loop; other site 644966001566 H-loop/switch region; other site 644966001567 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 644966001568 NMT1-like family; Region: NMT1_2; cl15260 644966001569 Protein of unknown function (DUF1806); Region: DUF1806; pfam08830 644966001570 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 644966001571 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644966001572 metal binding site 2 [ion binding]; metal-binding site 644966001573 putative DNA binding helix; other site 644966001574 metal binding site 1 [ion binding]; metal-binding site 644966001575 dimer interface [polypeptide binding]; other site 644966001576 structural Zn2+ binding site [ion binding]; other site 644966001577 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 644966001578 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 644966001579 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 644966001580 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644966001581 intersubunit interface [polypeptide binding]; other site 644966001582 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644966001583 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966001584 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 644966001585 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 644966001586 putative dimer interface [polypeptide binding]; other site 644966001587 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 644966001588 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 644966001589 Walker A/P-loop; other site 644966001590 ATP binding site [chemical binding]; other site 644966001591 Q-loop/lid; other site 644966001592 ABC transporter signature motif; other site 644966001593 Walker B; other site 644966001594 D-loop; other site 644966001595 H-loop/switch region; other site 644966001596 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 644966001597 Domain of unknown function DUF59; Region: DUF59; cl00941 644966001598 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966001599 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966001600 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 644966001601 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 644966001602 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 644966001603 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966001604 histidinol-phosphatase; Provisional; Region: PRK07328 644966001605 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 644966001606 N-acetyl-D-glucosamine binding site [chemical binding]; other site 644966001607 catalytic residue [active] 644966001608 NMT1-like family; Region: NMT1_2; cl15260 644966001609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644966001610 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644966001611 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 644966001612 Walker A/P-loop; other site 644966001613 ATP binding site [chemical binding]; other site 644966001614 Q-loop/lid; other site 644966001615 ABC transporter signature motif; other site 644966001616 Walker B; other site 644966001617 D-loop; other site 644966001618 H-loop/switch region; other site 644966001619 asparagine synthetase B; Provisional; Region: asnB; PRK09431 644966001620 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 644966001621 active site 644966001622 dimer interface [polypeptide binding]; other site 644966001623 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 644966001624 Ligand Binding Site [chemical binding]; other site 644966001625 Molecular Tunnel; other site 644966001626 leucine ABC transporter subunit substrate-binding protein LivK; Provisional; Region: PRK15404 644966001627 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 644966001628 dimerization interface [polypeptide binding]; other site 644966001629 ligand binding site [chemical binding]; other site 644966001630 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644966001631 TM-ABC transporter signature motif; other site 644966001632 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644966001633 TM-ABC transporter signature motif; other site 644966001634 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 644966001635 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 644966001636 Walker A/P-loop; other site 644966001637 ATP binding site [chemical binding]; other site 644966001638 Q-loop/lid; other site 644966001639 ABC transporter signature motif; other site 644966001640 Walker B; other site 644966001641 D-loop; other site 644966001642 H-loop/switch region; other site 644966001643 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 644966001644 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 644966001645 Walker A/P-loop; other site 644966001646 ATP binding site [chemical binding]; other site 644966001647 Q-loop/lid; other site 644966001648 ABC transporter signature motif; other site 644966001649 Walker B; other site 644966001650 D-loop; other site 644966001651 H-loop/switch region; other site 644966001652 EamA-like transporter family; Region: EamA; cl01037 644966001653 EamA-like transporter family; Region: EamA; cl01037 644966001654 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644966001655 active site 644966001656 phosphorylation site [posttranslational modification] 644966001657 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 644966001658 active site 644966001659 P-loop; other site 644966001660 phosphorylation site [posttranslational modification] 644966001661 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 644966001662 hypothetical protein; Provisional; Region: PRK02947 644966001663 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644966001664 putative active site [active] 644966001665 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 644966001666 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644966001667 DNA-binding site [nucleotide binding]; DNA binding site 644966001668 UTRA domain; Region: UTRA; cl01230 644966001669 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 644966001670 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 644966001671 active site 644966001672 dimer interface [polypeptide binding]; other site 644966001673 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 644966001674 active site 644966001675 trimer interface [polypeptide binding]; other site 644966001676 allosteric site; other site 644966001677 active site lid [active] 644966001678 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 644966001679 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644966001680 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966001681 Proline dehydrogenase; Region: Pro_dh; cl03282 644966001682 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 644966001683 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 644966001684 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 644966001685 metal binding site [ion binding]; metal-binding site 644966001686 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 644966001687 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 644966001688 phosphate binding site [ion binding]; other site 644966001689 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 644966001690 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 644966001691 catalytic residues [active] 644966001692 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 644966001693 putative active site [active] 644966001694 oxyanion strand; other site 644966001695 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 644966001696 imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951 644966001697 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 644966001698 putative active site pocket [active] 644966001699 4-fold oligomerization interface [polypeptide binding]; other site 644966001700 metal binding residues [ion binding]; metal-binding site 644966001701 3-fold/trimer interface [polypeptide binding]; other site 644966001702 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 644966001703 histidinol dehydrogenase; Region: hisD; TIGR00069 644966001704 NAD binding site [chemical binding]; other site 644966001705 dimerization interface [polypeptide binding]; other site 644966001706 product binding site; other site 644966001707 substrate binding site [chemical binding]; other site 644966001708 zinc binding site [ion binding]; other site 644966001709 catalytic residues [active] 644966001710 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 644966001711 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644966001712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966001713 homodimer interface [polypeptide binding]; other site 644966001714 catalytic residue [active] 644966001715 ATP phosphoribosyltransferase; Region: HisG; cl15266 644966001716 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 644966001717 motif 1; other site 644966001718 dimer interface [polypeptide binding]; other site 644966001719 active site 644966001720 motif 2; other site 644966001721 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 644966001722 motif 3; other site 644966001723 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 644966001724 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001725 EamA-like transporter family; Region: EamA; cl01037 644966001726 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 644966001727 ornithine cyclodeaminase; Validated; Region: PRK08618 644966001728 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001729 EamA-like transporter family; Region: EamA; cl01037 644966001730 Helix-turn-helix domains; Region: HTH; cl00088 644966001731 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644966001732 metal binding site 2 [ion binding]; metal-binding site 644966001733 putative DNA binding helix; other site 644966001734 metal binding site 1 [ion binding]; metal-binding site 644966001735 dimer interface [polypeptide binding]; other site 644966001736 structural Zn2+ binding site [ion binding]; other site 644966001737 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 644966001738 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644966001739 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966001740 Protein of unknown function (DUF554); Region: DUF554; cl00784 644966001741 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001742 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 644966001743 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001744 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966001745 Response regulator receiver domain; Region: Response_reg; pfam00072 644966001746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966001747 active site 644966001748 phosphorylation site [posttranslational modification] 644966001749 intermolecular recognition site; other site 644966001750 dimerization interface [polypeptide binding]; other site 644966001751 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966001752 DNA binding site [nucleotide binding] 644966001753 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 644966001754 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 644966001755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966001756 dimer interface [polypeptide binding]; other site 644966001757 phosphorylation site [posttranslational modification] 644966001758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966001759 ATP binding site [chemical binding]; other site 644966001760 G-X-G motif; other site 644966001761 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644966001762 active site 644966001763 Sporulation and spore germination; Region: Germane; cl11253 644966001764 Uncharacterized conserved protein [Function unknown]; Region: COG3342 644966001765 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 644966001766 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 644966001767 Protein of unknown function (DUF1006); Region: DUF1006; cl15826 644966001768 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644966001769 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644966001770 NAD(P) binding site [chemical binding]; other site 644966001771 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 644966001772 Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404 644966001773 NAD synthetase; Provisional; Region: PRK13981 644966001774 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 644966001775 multimer interface [polypeptide binding]; other site 644966001776 active site 644966001777 catalytic triad [active] 644966001778 protein interface 1 [polypeptide binding]; other site 644966001779 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 644966001780 homodimer interface [polypeptide binding]; other site 644966001781 NAD binding pocket [chemical binding]; other site 644966001782 ATP binding pocket [chemical binding]; other site 644966001783 Mg binding site [ion binding]; other site 644966001784 active-site loop [active] 644966001785 Mechanosensitive ion channel; Region: MS_channel; pfam00924 644966001786 NTF2-like N-terminal transpeptidase domain; Region: MecA_N; pfam05223 644966001787 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644966001788 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966001789 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966001790 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 644966001791 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 644966001792 dimer interface [polypeptide binding]; other site 644966001793 putative functional site; other site 644966001794 putative MPT binding site; other site 644966001795 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001796 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644966001797 DNA binding residues [nucleotide binding] 644966001798 glutamine synthetase, type I; Region: GlnA; TIGR00653 644966001799 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 644966001800 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 644966001801 ANTAR domain; Region: ANTAR; cl04297 644966001802 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 644966001803 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 644966001804 active site 644966001805 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 644966001806 dimer interface [polypeptide binding]; other site 644966001807 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 644966001808 Ligand Binding Site [chemical binding]; other site 644966001809 Molecular Tunnel; other site 644966001810 YceI-like domain; Region: YceI; cl01001 644966001811 Helix-turn-helix domains; Region: HTH; cl00088 644966001812 Carboxylesterase family; Region: COesterase; pfam00135 644966001813 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966001814 substrate binding pocket [chemical binding]; other site 644966001815 catalytic triad [active] 644966001816 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 644966001817 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 644966001818 active site 644966001819 dimer interface [polypeptide binding]; other site 644966001820 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 644966001821 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 644966001822 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 644966001823 active site 644966001824 FMN binding site [chemical binding]; other site 644966001825 substrate binding site [chemical binding]; other site 644966001826 3Fe-4S cluster binding site [ion binding]; other site 644966001827 Glutamate synthase domain 3 [Amino acid transport and metabolism]; Region: GltB; COG0070 644966001828 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 644966001829 domain interface; other site 644966001830 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966001831 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 644966001832 putative active site [active] 644966001833 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 644966001834 metabolite-proton symporter; Region: 2A0106; TIGR00883 644966001835 GPH family sucrose/H+ symporter; Region: GPH_sucrose; TIGR01301 644966001836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966001837 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 644966001838 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001839 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 644966001840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966001841 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644966001842 This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798 644966001843 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 644966001844 Bacterial SH3 domain; Region: SH3_3; cl02551 644966001845 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 644966001846 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644966001847 active site 644966001848 metal binding site [ion binding]; metal-binding site 644966001849 S-layer homology domain; Region: SLH; pfam00395 644966001850 S-layer homology domain; Region: SLH; pfam00395 644966001851 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 644966001852 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 644966001853 Stage II sporulation protein; Region: SpoIID; pfam08486 644966001854 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 644966001855 S-layer homology domain; Region: SLH; pfam00395 644966001856 S-layer homology domain; Region: SLH; pfam00395 644966001857 S-layer homology domain; Region: SLH; pfam00395 644966001858 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644966001859 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 644966001860 Domain of unknown function (DUF4330); Region: DUF4330; pfam14221 644966001861 O-Antigen ligase; Region: Wzy_C; cl04850 644966001862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644966001863 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 644966001864 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644966001865 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 644966001866 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 644966001867 Walker A/P-loop; other site 644966001868 ATP binding site [chemical binding]; other site 644966001869 Q-loop/lid; other site 644966001870 ABC transporter signature motif; other site 644966001871 Walker B; other site 644966001872 D-loop; other site 644966001873 H-loop/switch region; other site 644966001874 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 644966001875 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 644966001876 Walker A/P-loop; other site 644966001877 ATP binding site [chemical binding]; other site 644966001878 Q-loop/lid; other site 644966001879 ABC transporter signature motif; other site 644966001880 Walker B; other site 644966001881 D-loop; other site 644966001882 H-loop/switch region; other site 644966001883 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644966001884 TM-ABC transporter signature motif; other site 644966001885 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644966001886 TM-ABC transporter signature motif; other site 644966001887 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 644966001888 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 644966001889 putative ligand binding site [chemical binding]; other site 644966001890 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 644966001891 Protein of unknown function (DUF419); Region: DUF419; cl15265 644966001892 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 644966001893 NAD-dependent deacetylase; Provisional; Region: PRK00481 644966001894 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 644966001895 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 644966001896 DinB superfamily; Region: DinB_2; pfam12867 644966001897 Ubiquitin-like proteins; Region: UBQ; cl00155 644966001898 charged pocket; other site 644966001899 hydrophobic patch; other site 644966001900 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 644966001901 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966001902 Walker A motif; other site 644966001903 ATP binding site [chemical binding]; other site 644966001904 Walker B motif; other site 644966001905 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 644966001906 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 644966001907 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 644966001908 Type II/IV secretion system protein; Region: T2SE; pfam00437 644966001909 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 644966001910 Walker A motif; other site 644966001911 ATP binding site [chemical binding]; other site 644966001912 Walker B motif; other site 644966001913 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 644966001914 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 644966001915 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 644966001916 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 644966001917 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 644966001918 active site 644966001919 NTP binding site [chemical binding]; other site 644966001920 metal binding triad [ion binding]; metal-binding site 644966001921 antibiotic binding site [chemical binding]; other site 644966001922 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 644966001923 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 644966001924 Substrate binding site; other site 644966001925 Cupin domain; Region: Cupin_2; cl09118 644966001926 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 644966001927 active site 644966001928 tetramer interface; other site 644966001929 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 644966001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966001931 catalytic residue [active] 644966001932 Protein of unknown function DUF86; Region: DUF86; cl01031 644966001933 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 644966001934 active site 644966001935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 644966001936 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966001937 Transcriptional regulator [Transcription]; Region: IclR; COG1414 644966001938 Helix-turn-helix domains; Region: HTH; cl00088 644966001939 Bacterial transcriptional regulator; Region: IclR; pfam01614 644966001940 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 644966001941 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966001942 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966001943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966001944 dimer interface [polypeptide binding]; other site 644966001945 conserved gate region; other site 644966001946 putative PBP binding loops; other site 644966001947 ABC-ATPase subunit interface; other site 644966001948 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 644966001949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966001950 dimer interface [polypeptide binding]; other site 644966001951 conserved gate region; other site 644966001952 putative PBP binding loops; other site 644966001953 ABC-ATPase subunit interface; other site 644966001954 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966001955 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966001956 Walker A/P-loop; other site 644966001957 ATP binding site [chemical binding]; other site 644966001958 Q-loop/lid; other site 644966001959 ABC transporter signature motif; other site 644966001960 Walker B; other site 644966001961 D-loop; other site 644966001962 H-loop/switch region; other site 644966001963 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966001964 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 644966001965 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966001966 Walker A/P-loop; other site 644966001967 ATP binding site [chemical binding]; other site 644966001968 Q-loop/lid; other site 644966001969 ABC transporter signature motif; other site 644966001970 Walker B; other site 644966001971 D-loop; other site 644966001972 H-loop/switch region; other site 644966001973 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966001974 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 644966001975 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 644966001976 flagellar motor protein MotA; Validated; Region: PRK08124 644966001977 flagellar motor protein MotD; Reviewed; Region: PRK09038 644966001978 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 644966001979 ligand binding site [chemical binding]; other site 644966001980 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644966001981 Zn2+ binding site [ion binding]; other site 644966001982 Mg2+ binding site [ion binding]; other site 644966001983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 644966001984 binding surface 644966001985 TPR motif; other site 644966001986 GAF domain; Region: GAF; cl15785 644966001987 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 644966001988 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 644966001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 644966001990 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 644966001991 anti sigma factor interaction site; other site 644966001992 regulatory phosphorylation site [posttranslational modification]; other site 644966001993 Protein of unknown function (DUF342); Region: DUF342; pfam03961 644966001994 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 644966001995 Protein of unknown function (DUF342); Region: DUF342; pfam03961 644966001996 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 644966001997 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 644966001998 catalytic triad [active] 644966001999 putative active site [active] 644966002000 S-layer homology domain; Region: SLH; pfam00395 644966002001 S-layer homology domain; Region: SLH; pfam00395 644966002002 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644966002003 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644966002004 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 644966002005 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 644966002006 Walker A/P-loop; other site 644966002007 ATP binding site [chemical binding]; other site 644966002008 Q-loop/lid; other site 644966002009 ABC transporter signature motif; other site 644966002010 Walker B; other site 644966002011 D-loop; other site 644966002012 H-loop/switch region; other site 644966002013 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 644966002014 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644966002015 Bacterial sugar transferase; Region: Bac_transf; cl00939 644966002016 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 644966002017 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 644966002018 Helix-turn-helix domains; Region: HTH; cl00088 644966002019 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 644966002020 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 644966002021 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 644966002022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966002023 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 644966002024 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002025 Walker A/P-loop; other site 644966002026 ATP binding site [chemical binding]; other site 644966002027 Q-loop/lid; other site 644966002028 ABC transporter signature motif; other site 644966002029 Walker B; other site 644966002030 D-loop; other site 644966002031 H-loop/switch region; other site 644966002032 TOBE domain; Region: TOBE_2; cl01440 644966002033 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 644966002034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966002035 dimer interface [polypeptide binding]; other site 644966002036 conserved gate region; other site 644966002037 putative PBP binding loops; other site 644966002038 ABC-ATPase subunit interface; other site 644966002039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644966002040 Creatinine amidohydrolase; Region: Creatininase; cl00618 644966002041 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 644966002042 Argininosuccinate lyase [Amino acid transport and metabolism]; Region: ArgH; COG0165 644966002043 active sites [active] 644966002044 tetramer interface [polypeptide binding]; other site 644966002045 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 644966002046 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 644966002047 Protein of unknown function (DUF3423); Region: DUF3423; pfam11903 644966002048 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 644966002049 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 644966002050 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 644966002051 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002052 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 644966002053 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002054 NAD(P) binding site [chemical binding]; other site 644966002055 active site 644966002056 Predicted acetyltransferase [General function prediction only]; Region: COG3153 644966002057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644966002058 Coenzyme A binding pocket [chemical binding]; other site 644966002059 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 644966002060 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644966002061 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966002062 catalytic residue [active] 644966002063 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644966002064 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002065 Walker A/P-loop; other site 644966002066 ATP binding site [chemical binding]; other site 644966002067 Q-loop/lid; other site 644966002068 ABC transporter signature motif; other site 644966002069 Walker B; other site 644966002070 D-loop; other site 644966002071 H-loop/switch region; other site 644966002072 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644966002073 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 644966002074 Walker A/P-loop; other site 644966002075 ATP binding site [chemical binding]; other site 644966002076 Q-loop/lid; other site 644966002077 ABC transporter signature motif; other site 644966002078 Walker B; other site 644966002079 D-loop; other site 644966002080 H-loop/switch region; other site 644966002081 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 644966002082 ABC-2 type transporter; Region: ABC2_membrane; cl11417 644966002083 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 644966002084 Helix-turn-helix domains; Region: HTH; cl00088 644966002085 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 644966002086 dimer interface [polypeptide binding]; other site 644966002087 active site 644966002088 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 644966002089 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644966002090 Helix-turn-helix domains; Region: HTH; cl00088 644966002091 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 644966002092 hypothetical protein; Provisional; Region: PRK08185 644966002093 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 644966002094 intersubunit interface [polypeptide binding]; other site 644966002095 active site 644966002096 zinc binding site [ion binding]; other site 644966002097 Na+ binding site [ion binding]; other site 644966002098 Chromate transporter; Region: Chromate_transp; pfam02417 644966002099 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 644966002100 UV-endonuclease UvdE; Region: UvdE; cl10036 644966002101 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 644966002102 acyl-coenzyme A oxidase; Region: PLN02526 644966002103 active site 644966002104 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966002105 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 644966002106 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 644966002107 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966002108 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 644966002109 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 644966002110 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 644966002111 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 644966002112 GAF domain; Region: GAF_2; pfam13185 644966002113 GAF domain; Region: GAF; cl15785 644966002114 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 644966002115 metal binding site [ion binding]; metal-binding site 644966002116 active site 644966002117 I-site; other site 644966002118 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644966002119 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 644966002120 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 644966002121 putative NAD(P) binding site [chemical binding]; other site 644966002122 putative active site [active] 644966002123 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 644966002124 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 644966002125 Protein of unknown function (DUF1446); Region: DUF1446; pfam07287 644966002126 Domain of unknown function (DUF4387); Region: DUF4387; pfam14330 644966002127 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 644966002128 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 644966002129 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966002130 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966002131 dimer interface [polypeptide binding]; other site 644966002132 conserved gate region; other site 644966002133 putative PBP binding loops; other site 644966002134 ABC-ATPase subunit interface; other site 644966002135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644966002136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966002137 dimer interface [polypeptide binding]; other site 644966002138 conserved gate region; other site 644966002139 putative PBP binding loops; other site 644966002140 ABC-ATPase subunit interface; other site 644966002141 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 644966002142 catalytic triad [active] 644966002143 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 644966002144 amidohydrolase; Region: amidohydrolases; TIGR01891 644966002145 metal binding site [ion binding]; metal-binding site 644966002146 dimer interface [polypeptide binding]; other site 644966002147 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 644966002148 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966002149 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 644966002150 putative active site [active] 644966002151 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 644966002152 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 644966002153 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 644966002154 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 644966002155 dimer interface [polypeptide binding]; other site 644966002156 active site 644966002157 glycine-pyridoxal phosphate binding site [chemical binding]; other site 644966002158 folate binding site [chemical binding]; other site 644966002159 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 644966002160 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 644966002161 tetramerization interface [polypeptide binding]; other site 644966002162 active site 644966002163 EVE domain; Region: EVE; cl00728 644966002164 LytB protein; Region: LYTB; cl00507 644966002165 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 644966002166 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 644966002167 This family comprises the glycine betaine/L-proline ATP binding subunit in bacteria and its equivalents in archaea. This transport system belong to the larger ATP-Binding Cassette (ABC) transporter superfamily. The characteristic feature of these...; Region: ABC_Pro_Gly_Bertaine; cd03294 644966002168 Walker A/P-loop; other site 644966002169 ATP binding site [chemical binding]; other site 644966002170 Q-loop/lid; other site 644966002171 ABC transporter signature motif; other site 644966002172 Walker B; other site 644966002173 D-loop; other site 644966002174 H-loop/switch region; other site 644966002175 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 644966002176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966002177 dimer interface [polypeptide binding]; other site 644966002178 conserved gate region; other site 644966002179 putative PBP binding loops; other site 644966002180 ABC-ATPase subunit interface; other site 644966002181 NMT1-like family; Region: NMT1_2; cl15260 644966002182 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 644966002183 ferrochelatase; Provisional; Region: PRK12435 644966002184 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 644966002185 C-terminal domain interface [polypeptide binding]; other site 644966002186 active site 644966002187 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 644966002188 active site 644966002189 N-terminal domain interface [polypeptide binding]; other site 644966002190 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 644966002191 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002192 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 644966002193 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 644966002194 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 644966002195 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644966002196 metal binding site 2 [ion binding]; metal-binding site 644966002197 putative DNA binding helix; other site 644966002198 metal binding site 1 [ion binding]; metal-binding site 644966002199 dimer interface [polypeptide binding]; other site 644966002200 structural Zn2+ binding site [ion binding]; other site 644966002201 DoxX; Region: DoxX; cl00976 644966002202 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644966002203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966002204 active site 644966002205 phosphorylation site [posttranslational modification] 644966002206 intermolecular recognition site; other site 644966002207 dimerization interface [polypeptide binding]; other site 644966002208 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966002209 DNA binding site [nucleotide binding] 644966002210 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 644966002211 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966002212 dimer interface [polypeptide binding]; other site 644966002213 phosphorylation site [posttranslational modification] 644966002214 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966002215 ATP binding site [chemical binding]; other site 644966002216 Mg2+ binding site [ion binding]; other site 644966002217 G-X-G motif; other site 644966002218 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 644966002219 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002220 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 644966002221 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 644966002222 active site 644966002223 FMN binding site [chemical binding]; other site 644966002224 substrate binding site [chemical binding]; other site 644966002225 3Fe-4S cluster binding site [ion binding]; other site 644966002226 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 644966002227 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644966002228 minor groove reading motif; other site 644966002229 helix-hairpin-helix signature motif; other site 644966002230 substrate binding pocket [chemical binding]; other site 644966002231 active site 644966002232 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 644966002233 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 644966002234 active site 644966002235 dimerization interface [polypeptide binding]; other site 644966002236 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 644966002237 nudix motif; other site 644966002238 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 644966002239 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 644966002240 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644966002241 active site 644966002242 metal binding site [ion binding]; metal-binding site 644966002243 DNA binding site [nucleotide binding] 644966002244 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002245 ABC transporter signature motif; other site 644966002246 Walker B; other site 644966002247 D-loop; other site 644966002248 H-loop/switch region; other site 644966002249 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 644966002250 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 644966002251 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 644966002252 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002253 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 644966002254 Family description; Region: UvrD_C_2; cl15862 644966002255 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 644966002256 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 644966002257 classical (c) SDRs; Region: SDR_c; cd05233 644966002258 NAD(P) binding site [chemical binding]; other site 644966002259 active site 644966002260 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 644966002261 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644966002262 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 644966002263 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 644966002264 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 644966002265 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 644966002266 trimer interface [polypeptide binding]; other site 644966002267 putative metal binding site [ion binding]; other site 644966002268 Predicted acetyltransferase [General function prediction only]; Region: COG3153 644966002269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 644966002270 Coenzyme A binding pocket [chemical binding]; other site 644966002271 selenophosphate synthetase; Provisional; Region: PRK00943 644966002272 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 644966002273 dimerization interface [polypeptide binding]; other site 644966002274 putative ATP binding site [chemical binding]; other site 644966002275 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644966002276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl09944 644966002277 active site 644966002278 phosphorylation site [posttranslational modification] 644966002279 intermolecular recognition site; other site 644966002280 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644966002281 DNA binding residues [nucleotide binding] 644966002282 dimerization interface [polypeptide binding]; other site 644966002283 Y-family of DNA polymerases; Region: PolY; cl12025 644966002284 Y-family of DNA polymerases; Region: PolY; cl12025 644966002285 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 644966002286 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 644966002287 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 644966002288 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 644966002289 generic binding surface II; other site 644966002290 generic binding surface I; other site 644966002291 Protein of unknown function, DUF393; Region: DUF393; cl01136 644966002292 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 644966002293 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 644966002294 active site 644966002295 catalytic triad [active] 644966002296 dimer interface [polypeptide binding]; other site 644966002297 Predicted amidohydrolase [General function prediction only]; Region: COG0388 644966002298 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 644966002299 active site 644966002300 catalytic triad [active] 644966002301 dimer interface [polypeptide binding]; other site 644966002302 Acylphosphatase; Region: Acylphosphatase; cl00551 644966002303 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 644966002304 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644966002305 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 644966002306 Protein of unknown function (DUF441); Region: DUF441; cl01041 644966002307 NifU-like domain; Region: NifU; cl00484 644966002308 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 644966002309 trimer interface [polypeptide binding]; other site 644966002310 putative Zn binding site [ion binding]; other site 644966002311 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 644966002312 NADH dehydrogenase subunit 5; Validated; Region: PRK08601 644966002313 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 644966002314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002 644966002315 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 644966002316 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 644966002317 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 644966002318 active site 644966002319 Zn binding site [ion binding]; other site 644966002320 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 644966002321 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644966002322 protein binding site [polypeptide binding]; other site 644966002323 YwhD family; Region: YwhD; pfam08741 644966002324 YtxC-like family; Region: YtxC; cl08500 644966002325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 644966002326 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 644966002327 Amino acid permease; Region: AA_permease_2; pfam13520 644966002328 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 644966002329 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 644966002330 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 644966002331 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 644966002332 active site 644966002333 dimer interface [polypeptide binding]; other site 644966002334 motif 1; other site 644966002335 motif 2; other site 644966002336 motif 3; other site 644966002337 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 644966002338 anticodon binding site; other site 644966002339 translation initiation factor IF-3; Region: infC; TIGR00168 644966002340 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 644966002341 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 644966002342 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 644966002343 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 644966002344 23S rRNA binding site [nucleotide binding]; other site 644966002345 L21 binding site [polypeptide binding]; other site 644966002346 L13 binding site [polypeptide binding]; other site 644966002347 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 644966002348 Cation transport protein; Region: TrkH; cl10514 644966002349 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 644966002350 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002351 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 644966002352 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 644966002353 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 644966002354 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 644966002355 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644966002356 DNA binding residues [nucleotide binding] 644966002357 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 644966002358 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 644966002359 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 644966002360 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 644966002361 dimer interface [polypeptide binding]; other site 644966002362 motif 1; other site 644966002363 active site 644966002364 motif 2; other site 644966002365 motif 3; other site 644966002366 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 644966002367 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 644966002368 putative tRNA-binding site [nucleotide binding]; other site 644966002369 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 644966002370 B3/4 domain; Region: B3_4; cl11458 644966002371 tRNA synthetase B5 domain; Region: B5; cl08394 644966002372 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 644966002373 dimer interface [polypeptide binding]; other site 644966002374 motif 1; other site 644966002375 motif 3; other site 644966002376 motif 2; other site 644966002377 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 644966002378 Cell division protein ZapA; Region: ZapA; cl01146 644966002379 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 644966002380 hypothetical protein; Provisional; Region: PRK08609 644966002381 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 644966002382 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002383 Walker A/P-loop; other site 644966002384 ATP binding site [chemical binding]; other site 644966002385 Q-loop/lid; other site 644966002386 ABC transporter signature motif; other site 644966002387 Walker B; other site 644966002388 D-loop; other site 644966002389 H-loop/switch region; other site 644966002390 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 644966002391 Smr domain; Region: Smr; cl02619 644966002392 Transglycosylase; Region: Transgly; cl07896 644966002393 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 644966002394 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966002395 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 644966002396 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 644966002397 active site 644966002398 HIGH motif; other site 644966002399 dimer interface [polypeptide binding]; other site 644966002400 KMSKS motif; other site 644966002401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644966002402 RNA binding surface [nucleotide binding]; other site 644966002403 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 644966002404 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 644966002405 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 644966002406 dimer interface [polypeptide binding]; other site 644966002407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966002408 catalytic residue [active] 644966002409 Transcriptional regulator; Region: Transcrip_reg; cl00361 644966002410 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 644966002411 active site 644966002412 putative DNA-binding cleft [nucleotide binding]; other site 644966002413 dimer interface [polypeptide binding]; other site 644966002414 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 644966002415 RuvA N terminal domain; Region: RuvA_N; pfam01330 644966002416 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 644966002417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966002418 Walker A motif; other site 644966002419 ATP binding site [chemical binding]; other site 644966002420 Walker B motif; other site 644966002421 arginine finger; other site 644966002422 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 644966002423 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 644966002424 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 644966002425 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966002426 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 644966002427 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 644966002428 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 644966002429 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 644966002430 Preprotein translocase subunit; Region: YajC; cl00806 644966002431 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 644966002432 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 644966002433 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 644966002434 NAD(P) binding site [chemical binding]; other site 644966002435 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 644966002436 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 644966002437 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 644966002438 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 644966002439 carboxyltransferase (CT) interaction site; other site 644966002440 biotinylation site [posttranslational modification]; other site 644966002441 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 644966002442 cell division protein MraZ; Reviewed; Region: PRK00326 644966002443 MraZ protein; Region: MraZ; pfam02381 644966002444 MraZ protein; Region: MraZ; pfam02381 644966002445 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 644966002446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966002447 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 644966002448 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644966002449 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966002450 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 644966002451 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 644966002452 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 644966002453 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644966002454 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644966002455 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644966002456 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644966002457 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 644966002458 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644966002459 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 644966002460 phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445 644966002461 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 644966002462 Mg++ binding site [ion binding]; other site 644966002463 putative catalytic motif [active] 644966002464 putative substrate binding site [chemical binding]; other site 644966002465 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 644966002466 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 644966002467 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 644966002468 active site 644966002469 homodimer interface [polypeptide binding]; other site 644966002470 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 644966002471 FAD binding domain; Region: FAD_binding_4; pfam01565 644966002472 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 644966002473 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 644966002474 cell division protein FtsZ; Validated; Region: PRK09330 644966002475 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 644966002476 nucleotide binding site [chemical binding]; other site 644966002477 SulA interaction site; other site 644966002478 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 644966002479 sporulation sigma factor SigE; Reviewed; Region: PRK08301 644966002480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966002481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966002482 DNA binding residues [nucleotide binding] 644966002483 sporulation sigma factor SigG; Reviewed; Region: PRK08215 644966002484 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966002485 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644966002486 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966002487 DNA binding residues [nucleotide binding] 644966002488 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 644966002489 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 644966002490 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 644966002491 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 644966002492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 644966002493 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644966002494 catalytic residue [active] 644966002495 Protein of unknown function (DUF552); Region: DUF552; cl00775 644966002496 YGGT family; Region: YGGT; cl00508 644966002497 DivIVA protein; Region: DivIVA; pfam05103 644966002498 DivIVA domain; Region: DivI1A_domain; TIGR03544 644966002499 Integrase core domain; Region: rve; cl01316 644966002500 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 644966002501 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644966002502 active site 644966002503 HIGH motif; other site 644966002504 nucleotide binding site [chemical binding]; other site 644966002505 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644966002506 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 644966002507 active site 644966002508 KMSKS motif; other site 644966002509 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 644966002510 tRNA binding surface [nucleotide binding]; other site 644966002511 anticodon binding site; other site 644966002512 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 644966002513 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 644966002514 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 644966002515 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 644966002516 active site 644966002517 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 644966002518 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 644966002519 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 644966002520 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 644966002521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 644966002522 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644966002523 active site 644966002524 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644966002525 active site 644966002526 Glycerate kinase family; Region: Gly_kinase; cl00841 644966002527 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 644966002528 Domain of unknown function (DUF814); Region: DUF814; pfam05670 644966002529 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 644966002530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002531 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 644966002532 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 644966002533 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 644966002534 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966002535 substrate binding site [chemical binding]; other site 644966002536 oxyanion hole (OAH) forming residues; other site 644966002537 trimer interface [polypeptide binding]; other site 644966002538 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 644966002539 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 644966002540 dimer interface [polypeptide binding]; other site 644966002541 active site 644966002542 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 644966002543 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 644966002544 active site 644966002545 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966002546 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966002547 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 644966002548 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002549 CoA-ligase; Region: Ligase_CoA; cl02894 644966002550 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966002551 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 644966002552 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002553 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 644966002554 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 644966002555 B12 binding site [chemical binding]; other site 644966002556 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 644966002557 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 644966002558 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 644966002559 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644966002560 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 644966002561 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644966002562 motif II; other site 644966002563 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 644966002564 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 644966002565 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 644966002566 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 644966002567 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 644966002568 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 644966002569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966002570 homodimer interface [polypeptide binding]; other site 644966002571 catalytic residue [active] 644966002572 Protein of unknown function (DUF402); Region: DUF402; cl00979 644966002573 hypothetical protein; Provisional; Region: PRK11820 644966002574 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 644966002575 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 644966002576 Domain of unknown function (DUF370); Region: DUF370; cl00898 644966002577 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 644966002578 catalytic site [active] 644966002579 G-X2-G-X-G-K; other site 644966002580 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 644966002581 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 644966002582 Flavoprotein; Region: Flavoprotein; cl08021 644966002583 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 644966002584 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 644966002585 primosome assembly protein PriA; Validated; Region: PRK05580 644966002586 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644966002587 ATP binding site [chemical binding]; other site 644966002588 putative Mg++ binding site [ion binding]; other site 644966002589 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002590 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 644966002591 active site 644966002592 catalytic residues [active] 644966002593 metal binding site [ion binding]; metal-binding site 644966002594 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 644966002595 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 644966002596 putative active site [active] 644966002597 substrate binding site [chemical binding]; other site 644966002598 putative cosubstrate binding site; other site 644966002599 catalytic site [active] 644966002600 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 644966002601 substrate binding site [chemical binding]; other site 644966002602 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 644966002603 16S rRNA methyltransferase B; Provisional; Region: PRK14902 644966002604 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 644966002605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966002606 S-adenosylmethionine binding site [chemical binding]; other site 644966002607 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 644966002608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644966002609 FeS/SAM binding site; other site 644966002610 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 644966002611 active site 644966002612 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966002613 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 644966002614 active site 644966002615 ATP binding site [chemical binding]; other site 644966002616 substrate binding site [chemical binding]; other site 644966002617 activation loop (A-loop); other site 644966002618 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644966002619 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644966002620 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 644966002621 GTPase RsgA; Reviewed; Region: PRK00098 644966002622 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644966002623 RNA binding site [nucleotide binding]; other site 644966002624 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 644966002625 GTPase/Zn-binding domain interface [polypeptide binding]; other site 644966002626 GTP/Mg2+ binding site [chemical binding]; other site 644966002627 G4 box; other site 644966002628 G5 box; other site 644966002629 G1 box; other site 644966002630 Switch I region; other site 644966002631 G2 box; other site 644966002632 G3 box; other site 644966002633 Switch II region; other site 644966002634 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 644966002635 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 644966002636 hexamer interface [polypeptide binding]; other site 644966002637 metal binding site [ion binding]; metal-binding site 644966002638 substrate binding site [chemical binding]; other site 644966002639 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 644966002640 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 644966002641 dimerization interface [polypeptide binding]; other site 644966002642 domain crossover interface; other site 644966002643 redox-dependent activation switch; other site 644966002644 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 644966002645 Asp23 family; Region: Asp23; cl00574 644966002646 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 644966002647 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 644966002648 generic binding surface II; other site 644966002649 ssDNA binding site; other site 644966002650 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644966002651 ATP binding site [chemical binding]; other site 644966002652 putative Mg++ binding site [ion binding]; other site 644966002653 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644966002654 nucleotide binding region [chemical binding]; other site 644966002655 ATP-binding site [chemical binding]; other site 644966002656 Germination protease; Region: Peptidase_A25; cl04057 644966002657 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966002658 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644966002659 putative substrate translocation pore; other site 644966002660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966002661 S-adenosylmethionine binding site [chemical binding]; other site 644966002662 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 644966002663 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 644966002664 active site 644966002665 (T/H)XGH motif; other site 644966002666 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 644966002667 Nucleoside recognition; Region: Gate; cl00486 644966002668 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 644966002669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002670 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002671 CRISPR/Cas system-associated protein Csb2; Region: Csb2_I-U; cl09827 644966002672 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 644966002673 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 644966002674 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 644966002675 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 644966002676 Helix-turn-helix domains; Region: HTH; cl00088 644966002677 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 644966002678 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 644966002679 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 644966002680 dimer interface [polypeptide binding]; other site 644966002681 active site 644966002682 CoA binding pocket [chemical binding]; other site 644966002683 Acyl transferase domain; Region: Acyl_transf_1; cl08282 644966002684 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 644966002685 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 644966002686 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002688 NAD(P) binding site [chemical binding]; other site 644966002689 active site 644966002690 Phosphopantetheine attachment site; Region: PP-binding; cl09936 644966002691 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 644966002692 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 644966002693 dimer interface [polypeptide binding]; other site 644966002694 active site 644966002695 ribonuclease III; Reviewed; Region: rnc; PRK00102 644966002696 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 644966002697 dimerization interface [polypeptide binding]; other site 644966002698 active site 644966002699 metal binding site [ion binding]; metal-binding site 644966002700 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 644966002701 dsRNA binding site [nucleotide binding]; other site 644966002702 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 644966002703 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 644966002704 Walker A/P-loop; other site 644966002705 ATP binding site [chemical binding]; other site 644966002706 Q-loop/lid; other site 644966002707 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 644966002708 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 644966002709 Q-loop/lid; other site 644966002710 ABC transporter signature motif; other site 644966002711 Walker B; other site 644966002712 D-loop; other site 644966002713 H-loop/switch region; other site 644966002714 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 644966002715 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 644966002716 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 644966002717 P loop; other site 644966002718 GTP binding site [chemical binding]; other site 644966002719 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966002720 DNA binding residues [nucleotide binding] 644966002721 signal recognition particle protein; Provisional; Region: PRK10867 644966002722 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 644966002723 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 644966002724 P loop; other site 644966002725 GTP binding site [chemical binding]; other site 644966002726 Signal peptide binding domain; Region: SRP_SPB; pfam02978 644966002727 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 644966002728 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 644966002729 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 644966002730 RimM N-terminal domain; Region: RimM; pfam01782 644966002731 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 644966002732 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 644966002733 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 644966002734 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644966002735 Catalytic site [active] 644966002736 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002737 GTP/Mg2+ binding site [chemical binding]; other site 644966002738 G4 box; other site 644966002739 G5 box; other site 644966002740 G1 box; other site 644966002741 Switch I region; other site 644966002742 G2 box; other site 644966002743 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 644966002744 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 644966002745 RNA/DNA hybrid binding site [nucleotide binding]; other site 644966002746 active site 644966002747 Restriction endonuclease; Region: Mrr_cat; cl00516 644966002748 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 644966002749 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 644966002750 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002751 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 644966002752 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 644966002753 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966002754 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 644966002755 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 644966002756 DNA topoisomerase I; Validated; Region: PRK05582 644966002757 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 644966002758 active site 644966002759 interdomain interaction site; other site 644966002760 putative metal-binding site [ion binding]; other site 644966002761 nucleotide binding site [chemical binding]; other site 644966002762 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 644966002763 domain I; other site 644966002764 DNA binding groove [nucleotide binding] 644966002765 phosphate binding site [ion binding]; other site 644966002766 domain II; other site 644966002767 domain III; other site 644966002768 nucleotide binding site [chemical binding]; other site 644966002769 catalytic site [active] 644966002770 domain IV; other site 644966002771 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644966002772 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644966002773 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644966002774 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 644966002775 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002776 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 644966002777 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644966002778 active site 644966002779 DNA binding site [nucleotide binding] 644966002780 Int/Topo IB signature motif; other site 644966002781 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 644966002782 active site 644966002783 HslU subunit interaction site [polypeptide binding]; other site 644966002784 ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Posttranslational modification, protein turnover, chaperones]; Region: HslU; COG1220 644966002785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966002786 Walker A motif; other site 644966002787 ATP binding site [chemical binding]; other site 644966002788 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002789 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 644966002790 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 644966002791 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 644966002792 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 644966002793 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 644966002794 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 644966002795 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 644966002796 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 644966002797 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 644966002798 FliG C-terminal domain; Region: FliG_C; pfam01706 644966002799 Flagellar assembly protein FliH; Region: FliH; pfam02108 644966002800 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 644966002801 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 644966002802 Walker A motif/ATP binding site; other site 644966002803 Walker B motif; other site 644966002804 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 644966002805 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 644966002806 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 644966002807 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 644966002808 Flagella basal body rod protein; Region: Flg_bb_rod; cl16922 644966002809 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 644966002810 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 644966002811 Flagellar protein (FlbD); Region: FlbD; cl00683 644966002812 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 644966002813 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 644966002814 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 644966002815 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 644966002816 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 644966002817 FliP family; Region: FliP; cl00593 644966002818 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 644966002819 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 644966002820 flagellar biosynthetic protein FlhB; Region: flhB; TIGR00328 644966002821 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 644966002822 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 644966002823 FHIPEP family; Region: FHIPEP; pfam00771 644966002824 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 644966002825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002826 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 644966002827 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002828 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 644966002829 Flagellar protein YcgR; Region: YcgR_2; pfam12945 644966002830 PilZ domain; Region: PilZ; cl01260 644966002831 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 644966002832 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966002833 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644966002834 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966002835 DNA binding residues [nucleotide binding] 644966002836 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 644966002837 rRNA interaction site [nucleotide binding]; other site 644966002838 S8 interaction site; other site 644966002839 putative laminin-1 binding site; other site 644966002840 elongation factor Ts; Reviewed; Region: tsf; PRK12332 644966002841 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 644966002842 Elongation factor TS; Region: EF_TS; pfam00889 644966002843 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 644966002844 putative nucleotide binding site [chemical binding]; other site 644966002845 uridine monophosphate binding site [chemical binding]; other site 644966002846 homohexameric interface [polypeptide binding]; other site 644966002847 ribosome recycling factor; Reviewed; Region: frr; PRK00083 644966002848 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 644966002849 hinge region; other site 644966002850 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 644966002851 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 644966002852 catalytic residue [active] 644966002853 putative FPP diphosphate binding site; other site 644966002854 putative FPP binding hydrophobic cleft; other site 644966002855 dimer interface [polypeptide binding]; other site 644966002856 putative IPP diphosphate binding site; other site 644966002857 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 644966002858 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 644966002859 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 644966002860 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 644966002861 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 644966002862 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 644966002863 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 644966002864 active site 644966002865 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 644966002866 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 644966002867 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 644966002868 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 644966002869 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 644966002870 prolyl-tRNA synthetase; Provisional; Region: PRK09194 644966002871 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 644966002872 dimer interface [polypeptide binding]; other site 644966002873 motif 1; other site 644966002874 active site 644966002875 motif 2; other site 644966002876 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 644966002877 putative deacylase active site [active] 644966002878 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 644966002879 active site 644966002880 motif 3; other site 644966002881 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 644966002882 anticodon binding site; other site 644966002883 Domain of unknown function (DUF4010); Region: DUF4010; pfam13194 644966002884 Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576 644966002885 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 644966002886 Sm1 motif; other site 644966002887 D1 - D2 interaction site; other site 644966002888 D3 - B interaction site; other site 644966002889 Hfq - Hfq interaction site; other site 644966002890 RNA binding pocket [nucleotide binding]; other site 644966002891 Sm2 motif; other site 644966002892 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 644966002893 NusA N-terminal domain; Region: NusA_N; pfam08529 644966002894 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 644966002895 RNA binding site [nucleotide binding]; other site 644966002896 homodimer interface [polypeptide binding]; other site 644966002897 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 644966002898 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 644966002899 G-X-X-G motif; other site 644966002900 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 644966002901 putative RNA binding cleft [nucleotide binding]; other site 644966002902 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 644966002903 translation initiation factor IF-2; Region: IF-2; TIGR00487 644966002904 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 644966002905 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 644966002906 G1 box; other site 644966002907 putative GEF interaction site [polypeptide binding]; other site 644966002908 GTP/Mg2+ binding site [chemical binding]; other site 644966002909 Switch I region; other site 644966002910 G2 box; other site 644966002911 G3 box; other site 644966002912 Switch II region; other site 644966002913 G4 box; other site 644966002914 G5 box; other site 644966002915 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 644966002916 Translation-initiation factor 2; Region: IF-2; pfam11987 644966002917 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 644966002918 Protein of unknown function (DUF503); Region: DUF503; cl00669 644966002919 Ribosome-binding factor A; Region: RBFA; cl00542 644966002920 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 644966002921 DHH family; Region: DHH; pfam01368 644966002922 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 644966002923 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 644966002924 RNA binding site [nucleotide binding]; other site 644966002925 active site 644966002926 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 644966002927 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 644966002928 active site 644966002929 Riboflavin kinase; Region: Flavokinase; cl03312 644966002930 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 644966002931 16S/18S rRNA binding site [nucleotide binding]; other site 644966002932 S13e-L30e interaction site [polypeptide binding]; other site 644966002933 25S rRNA binding site [nucleotide binding]; other site 644966002934 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 644966002935 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 644966002936 RNase E interface [polypeptide binding]; other site 644966002937 trimer interface [polypeptide binding]; other site 644966002938 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 644966002939 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 644966002940 RNase E interface [polypeptide binding]; other site 644966002941 trimer interface [polypeptide binding]; other site 644966002942 active site 644966002943 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 644966002944 putative nucleic acid binding region [nucleotide binding]; other site 644966002945 G-X-X-G motif; other site 644966002946 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 644966002947 RNA binding site [nucleotide binding]; other site 644966002948 domain interface; other site 644966002949 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 644966002950 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 644966002951 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644966002952 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 644966002953 trimer interface [polypeptide binding]; other site 644966002954 active site 644966002955 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 644966002956 dihydrodipicolinate reductase; Provisional; Region: PRK00048 644966002957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002958 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 644966002959 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 644966002960 Flavoprotein; Region: Flavoprotein; cl08021 644966002961 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 644966002962 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002963 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 644966002964 aspartate kinase I; Reviewed; Region: PRK08210 644966002965 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 644966002966 nucleotide binding site [chemical binding]; other site 644966002967 substrate binding site [chemical binding]; other site 644966002968 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644966002969 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644966002970 dihydrodipicolinate synthase; Region: dapA; TIGR00674 644966002971 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 644966002972 dimer interface [polypeptide binding]; other site 644966002973 active site 644966002974 catalytic residue [active] 644966002975 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 644966002976 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966002977 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 644966002978 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 644966002979 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 644966002980 active site 644966002981 YlzJ-like protein; Region: YlzJ; pfam14035 644966002982 Bacitracin resistance protein BacA; Region: BacA; cl00858 644966002983 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966002984 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 644966002985 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 644966002986 active site 644966002987 Glyco_18 domain; Region: Glyco_18; smart00636 644966002988 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 644966002989 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966002990 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782 644966002991 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 644966002992 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 644966002993 active site 644966002994 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 644966002995 Glyco_18 domain; Region: Glyco_18; smart00636 644966002996 active site 644966002997 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 644966002998 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 644966002999 FAD binding site [chemical binding]; other site 644966003000 homotetramer interface [polypeptide binding]; other site 644966003001 substrate binding pocket [chemical binding]; other site 644966003002 catalytic base [active] 644966003003 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 644966003004 active site 644966003005 catalytic residues [active] 644966003006 metal binding site [ion binding]; metal-binding site 644966003007 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 644966003008 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966003009 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 644966003010 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 644966003011 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 644966003012 Dimer interface [polypeptide binding]; other site 644966003013 anticodon binding site; other site 644966003014 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 644966003015 homodimer interface [polypeptide binding]; other site 644966003016 motif 1; other site 644966003017 motif 2; other site 644966003018 active site 644966003019 motif 3; other site 644966003020 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 644966003021 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 644966003022 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 644966003023 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966003024 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 644966003025 NodB motif; other site 644966003026 active site 644966003027 catalytic site [active] 644966003028 metal binding site [ion binding]; metal-binding site 644966003029 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 644966003030 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 644966003031 active site 644966003032 substrate binding site [chemical binding]; other site 644966003033 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 644966003034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644966003035 ATP binding site [chemical binding]; other site 644966003036 putative Mg++ binding site [ion binding]; other site 644966003037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644966003038 nucleotide binding region [chemical binding]; other site 644966003039 ATP-binding site [chemical binding]; other site 644966003040 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 644966003041 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 644966003042 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 644966003043 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 644966003044 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 644966003045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966003046 Walker A motif; other site 644966003047 ATP binding site [chemical binding]; other site 644966003048 Walker B motif; other site 644966003049 arginine finger; other site 644966003050 Peptidase family M41; Region: Peptidase_M41; pfam01434 644966003051 competence damage-inducible protein A; Provisional; Region: PRK00549 644966003052 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 644966003053 putative MPT binding site; other site 644966003054 Competence-damaged protein; Region: CinA; cl00666 644966003055 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 644966003056 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644966003057 active site 644966003058 metal binding site [ion binding]; metal-binding site 644966003059 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 644966003060 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 644966003061 recombinase A; Provisional; Region: recA; PRK09354 644966003062 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 644966003063 hexamer interface [polypeptide binding]; other site 644966003064 Walker A motif; other site 644966003065 ATP binding site [chemical binding]; other site 644966003066 Walker B motif; other site 644966003067 RecX family; Region: RecX; cl00936 644966003068 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 644966003069 phosphodiesterase; Provisional; Region: PRK12704 644966003070 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644966003071 Zn2+ binding site [ion binding]; other site 644966003072 Mg2+ binding site [ion binding]; other site 644966003073 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 644966003074 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 644966003075 putative active site [active] 644966003076 metal binding site [ion binding]; metal-binding site 644966003077 homodimer binding site [polypeptide binding]; other site 644966003078 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 644966003079 active site 644966003080 dimer interface [polypeptide binding]; other site 644966003081 Cytosol aminopeptidase family, N-terminal domain; Region: Peptidase_M17_N; pfam02789 644966003082 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 644966003083 interface (dimer of trimers) [polypeptide binding]; other site 644966003084 Substrate-binding/catalytic site; other site 644966003085 Zn-binding sites [ion binding]; other site 644966003086 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 644966003087 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 644966003088 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 644966003089 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644966003090 FeS/SAM binding site; other site 644966003091 TRAM domain; Region: TRAM; cl01282 644966003092 MutS domain I; Region: MutS_I; pfam01624 644966003093 MutS domain II; Region: MutS_II; pfam05188 644966003094 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 644966003095 MutS family domain IV; Region: MutS_IV; pfam05190 644966003096 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 644966003097 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644966003098 Walker A/P-loop; other site 644966003099 ATP binding site [chemical binding]; other site 644966003100 Q-loop/lid; other site 644966003101 ABC transporter signature motif; other site 644966003102 Walker B; other site 644966003103 D-loop; other site 644966003104 H-loop/switch region; other site 644966003105 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 644966003106 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 644966003107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966003108 ATP binding site [chemical binding]; other site 644966003109 Mg2+ binding site [ion binding]; other site 644966003110 G-X-G motif; other site 644966003111 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 644966003112 ATP binding site [chemical binding]; other site 644966003113 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 644966003114 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 644966003115 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 644966003116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003117 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 644966003118 G1 box; other site 644966003119 GTP/Mg2+ binding site [chemical binding]; other site 644966003120 G2 box; other site 644966003121 Switch I region; other site 644966003122 G3 box; other site 644966003123 Switch II region; other site 644966003124 G4 box; other site 644966003125 G5 box; other site 644966003126 stage V sporulation protein K; Region: spore_V_K; TIGR02881 644966003127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966003128 Walker A motif; other site 644966003129 ATP binding site [chemical binding]; other site 644966003130 Walker B motif; other site 644966003131 arginine finger; other site 644966003132 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 644966003133 HflX GTPase family; Region: HflX; cd01878 644966003134 G1 box; other site 644966003135 GTP/Mg2+ binding site [chemical binding]; other site 644966003136 Switch I region; other site 644966003137 G2 box; other site 644966003138 G3 box; other site 644966003139 Switch II region; other site 644966003140 G4 box; other site 644966003141 Protein of unknown function (DUF456); Region: DUF456; cl01069 644966003142 LexA repressor; Validated; Region: PRK00215 644966003143 Helix-turn-helix domains; Region: HTH; cl00088 644966003144 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 644966003145 Catalytic site [active] 644966003146 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966003147 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 644966003148 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966003149 substrate binding site [chemical binding]; other site 644966003150 oxyanion hole (OAH) forming residues; other site 644966003151 trimer interface [polypeptide binding]; other site 644966003152 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272 644966003153 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 644966003154 putative NAD(P) binding site [chemical binding]; other site 644966003155 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644966003156 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 644966003157 active site 644966003158 metal binding site [ion binding]; metal-binding site 644966003159 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 644966003160 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 644966003161 NAD(P) binding site [chemical binding]; other site 644966003162 catalytic residues [active] 644966003163 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966003164 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 644966003165 NodB motif; other site 644966003166 active site 644966003167 catalytic site [active] 644966003168 metal binding site [ion binding]; metal-binding site 644966003169 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 644966003170 Survival protein SurE; Region: SurE; cl00448 644966003171 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 644966003172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003173 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 644966003174 catalytic core [active] 644966003175 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 644966003176 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003177 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 644966003178 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 644966003179 active site 644966003180 putative substrate binding pocket [chemical binding]; other site 644966003181 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 644966003182 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003183 oligomerization interface [polypeptide binding]; other site 644966003184 active site 644966003185 NAD+ binding site [chemical binding]; other site 644966003186 Helix-turn-helix domains; Region: HTH; cl00088 644966003187 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 644966003188 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 644966003189 active site 644966003190 multimer interface [polypeptide binding]; other site 644966003191 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 644966003192 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644966003193 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 644966003194 MoaE interaction surface [polypeptide binding]; other site 644966003195 MoeB interaction surface [polypeptide binding]; other site 644966003196 thiocarboxylated glycine; other site 644966003197 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 644966003198 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 644966003199 ATP binding site [chemical binding]; other site 644966003200 substrate interface [chemical binding]; other site 644966003201 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644966003202 active site residue [active] 644966003203 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 644966003204 MPN+ (JAMM) motif; other site 644966003205 Zinc-binding site [ion binding]; other site 644966003206 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 644966003207 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003208 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 644966003209 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 644966003210 GTP-binding protein Der; Reviewed; Region: PRK00093 644966003211 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 644966003212 G1 box; other site 644966003213 GTP/Mg2+ binding site [chemical binding]; other site 644966003214 Switch I region; other site 644966003215 G2 box; other site 644966003216 Switch II region; other site 644966003217 G3 box; other site 644966003218 G4 box; other site 644966003219 G5 box; other site 644966003220 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 644966003221 G1 box; other site 644966003222 GTP/Mg2+ binding site [chemical binding]; other site 644966003223 Switch I region; other site 644966003224 G2 box; other site 644966003225 G3 box; other site 644966003226 Switch II region; other site 644966003227 G4 box; other site 644966003228 G5 box; other site 644966003229 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 644966003230 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 644966003231 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 644966003232 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 644966003233 RNA binding site [nucleotide binding]; other site 644966003234 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 644966003235 RNA binding site [nucleotide binding]; other site 644966003236 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 644966003237 RNA binding site [nucleotide binding]; other site 644966003238 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644966003239 RNA binding site [nucleotide binding]; other site 644966003240 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 644966003241 putative acyl-acceptor binding pocket; other site 644966003242 cytidylate kinase; Provisional; Region: cmk; PRK00023 644966003243 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 644966003244 CMP-binding site; other site 644966003245 The sites determining sugar specificity; other site 644966003246 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 644966003247 putative active site pocket [active] 644966003248 dimerization interface [polypeptide binding]; other site 644966003249 putative catalytic residue [active] 644966003250 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 644966003251 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 644966003252 putative oxidoreductase FixC; Provisional; Region: PRK10157 644966003253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003254 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 644966003255 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 644966003256 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 644966003257 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 644966003258 Ligand binding site [chemical binding]; other site 644966003259 Electron transfer flavoprotein domain; Region: ETF; pfam01012 644966003260 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 644966003261 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 644966003262 active site 644966003263 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 644966003264 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644966003265 RNA binding surface [nucleotide binding]; other site 644966003266 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 644966003267 active site 644966003268 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 644966003269 homotrimer interaction site [polypeptide binding]; other site 644966003270 putative active site [active] 644966003271 Nucleoside recognition; Region: Gate; cl00486 644966003272 Nucleoside recognition; Region: Gate; cl00486 644966003273 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 644966003274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644966003275 ATP binding site [chemical binding]; other site 644966003276 putative Mg++ binding site [ion binding]; other site 644966003277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644966003278 nucleotide binding region [chemical binding]; other site 644966003279 ATP-binding site [chemical binding]; other site 644966003280 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 644966003281 nucleotide binding site [chemical binding]; other site 644966003282 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 644966003283 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 644966003284 active site 644966003285 DNA binding site [nucleotide binding] 644966003286 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 644966003287 DNA binding site [nucleotide binding] 644966003288 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 644966003289 DNA binding site [nucleotide binding] 644966003290 heterodimer interface [polypeptide binding]; other site 644966003291 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an autoantigen...; Region: KU; cl02666 644966003292 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 644966003293 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 644966003294 ScpA/B protein; Region: ScpA_ScpB; cl00598 644966003295 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 644966003296 active site 644966003297 putative substrate binding region [chemical binding]; other site 644966003298 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 644966003299 SpoVA protein; Region: SpoVA; cl04298 644966003300 stage V sporulation protein AD; Validated; Region: PRK08304 644966003301 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 644966003302 active site 644966003303 SpoVA protein; Region: SpoVA; cl04298 644966003304 Dodecin; Region: Dodecin; cl01328 644966003305 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 644966003306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966003307 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644966003308 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966003309 DNA binding residues [nucleotide binding] 644966003310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 644966003311 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 644966003312 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 644966003313 anti sigma factor interaction site; other site 644966003314 regulatory phosphorylation site [posttranslational modification]; other site 644966003315 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 644966003316 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966003317 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 644966003318 selenocysteine synthase; Provisional; Region: PRK04311 644966003319 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644966003320 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966003321 catalytic residue [active] 644966003322 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 644966003323 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 644966003324 active site 644966003325 DNA binding site [nucleotide binding] 644966003326 Int/Topo IB signature motif; other site 644966003327 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 644966003328 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 644966003329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003330 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 644966003331 dimer interface [polypeptide binding]; other site 644966003332 active site 644966003333 ADP-ribose binding site [chemical binding]; other site 644966003334 nudix motif; other site 644966003335 metal binding site [ion binding]; metal-binding site 644966003336 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 644966003337 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 644966003338 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 644966003339 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 644966003340 NAD binding site [chemical binding]; other site 644966003341 Phe binding site; other site 644966003342 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 644966003343 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 644966003344 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 644966003345 NAD binding site [chemical binding]; other site 644966003346 Phe binding site; other site 644966003347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 644966003348 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 644966003349 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 644966003350 Thiamine pyrophosphokinase; Region: TPK; cl08415 644966003351 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 644966003352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966003353 active site 644966003354 phosphorylation site [posttranslational modification] 644966003355 intermolecular recognition site; other site 644966003356 dimerization interface [polypeptide binding]; other site 644966003357 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 644966003358 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 644966003359 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 644966003360 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 644966003361 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 644966003362 Walker A/P-loop; other site 644966003363 ATP binding site [chemical binding]; other site 644966003364 Q-loop/lid; other site 644966003365 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 644966003366 ABC transporter signature motif; other site 644966003367 Walker B; other site 644966003368 D-loop; other site 644966003369 H-loop/switch region; other site 644966003370 arginine repressor; Provisional; Region: argR; PRK00441 644966003371 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 644966003372 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 644966003373 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 644966003374 tartrate dehydrogenase; Provisional; Region: PRK08194 644966003375 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 644966003376 M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885 644966003377 Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546 644966003378 metal binding site [ion binding]; metal-binding site 644966003379 dimer interface [polypeptide binding]; other site 644966003380 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 644966003381 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 644966003382 inhibitor site; inhibition site 644966003383 active site 644966003384 dimer interface [polypeptide binding]; other site 644966003385 catalytic residue [active] 644966003386 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 644966003387 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644966003388 RNA binding surface [nucleotide binding]; other site 644966003389 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966003390 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 644966003391 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 644966003392 TPP-binding site; other site 644966003393 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644966003394 PYR/PP interface [polypeptide binding]; other site 644966003395 dimer interface [polypeptide binding]; other site 644966003396 TPP binding site [chemical binding]; other site 644966003397 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644966003398 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 644966003399 substrate binding pocket [chemical binding]; other site 644966003400 chain length determination region; other site 644966003401 substrate-Mg2+ binding site; other site 644966003402 catalytic residues [active] 644966003403 aspartate-rich region 1; other site 644966003404 active site lid residues [active] 644966003405 aspartate-rich region 2; other site 644966003406 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 644966003407 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 644966003408 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 644966003409 generic binding surface II; other site 644966003410 generic binding surface I; other site 644966003411 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 644966003412 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 644966003413 homodimer interface [polypeptide binding]; other site 644966003414 NADP binding site [chemical binding]; other site 644966003415 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 644966003416 Asp23 family; Region: Asp23; cl00574 644966003417 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 644966003418 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 644966003419 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 644966003420 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 644966003421 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 644966003422 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 644966003423 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 644966003424 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 644966003425 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 644966003426 elongation factor P; Validated; Region: PRK00529 644966003427 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 644966003428 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 644966003429 RNA binding site [nucleotide binding]; other site 644966003430 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 644966003431 RNA binding site [nucleotide binding]; other site 644966003432 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 644966003433 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 644966003434 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 644966003435 active site 644966003436 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 644966003437 active site 644966003438 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 644966003439 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 644966003440 tetramer interface [polypeptide binding]; other site 644966003441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966003442 catalytic residue [active] 644966003443 glycine dehydrogenase subunit 1; Validated; Region: PRK00451 644966003444 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 644966003445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966003446 tetramer interface [polypeptide binding]; other site 644966003447 catalytic residue [active] 644966003448 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 644966003449 lipoyl attachment site [posttranslational modification]; other site 644966003450 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 644966003451 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 644966003452 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 644966003453 nudix motif; other site 644966003454 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 644966003455 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 644966003456 putative ADP-binding pocket [chemical binding]; other site 644966003457 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 644966003458 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 644966003459 helicase/secretion neighborhood ATPase; Region: heli_sec_ATPase; TIGR03819 644966003460 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 644966003461 ATP binding site [chemical binding]; other site 644966003462 Walker A motif; other site 644966003463 hexamer interface [polypeptide binding]; other site 644966003464 Walker B motif; other site 644966003465 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 644966003466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003467 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 644966003468 FlgD Ig-like domain; Region: FlgD_ig; cl15790 644966003469 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 644966003470 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 644966003471 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 644966003472 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 644966003473 ATP binding site [chemical binding]; other site 644966003474 Walker A motif; other site 644966003475 hexamer interface [polypeptide binding]; other site 644966003476 Walker B motif; other site 644966003477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966003478 active site 644966003479 phosphorylation site [posttranslational modification] 644966003480 intermolecular recognition site; other site 644966003481 dimerization interface [polypeptide binding]; other site 644966003482 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 644966003483 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 644966003484 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003485 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 644966003486 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644966003487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966003488 active site 644966003489 phosphorylation site [posttranslational modification] 644966003490 intermolecular recognition site; other site 644966003491 dimerization interface [polypeptide binding]; other site 644966003492 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644966003493 DNA binding residues [nucleotide binding] 644966003494 dimerization interface [polypeptide binding]; other site 644966003495 Sensor protein DegS; Region: DegS; pfam05384 644966003496 Histidine kinase; Region: HisKA_3; pfam07730 644966003497 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 644966003498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966003499 ATP binding site [chemical binding]; other site 644966003500 Mg2+ binding site [ion binding]; other site 644966003501 G-X-G motif; other site 644966003502 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 644966003503 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644966003504 motif II; other site 644966003505 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 644966003506 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966003507 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966003508 DNA binding residues [nucleotide binding] 644966003509 YceG-like family; Region: YceG; pfam02618 644966003510 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 644966003511 dimerization interface [polypeptide binding]; other site 644966003512 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 644966003513 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 644966003514 Rhomboid family; Region: Rhomboid; cl11446 644966003515 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 644966003516 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 644966003517 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 644966003518 motif 1; other site 644966003519 active site 644966003520 motif 2; other site 644966003521 motif 3; other site 644966003522 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 644966003523 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 644966003524 Domain of unknown function DUF20; Region: UPF0118; pfam01594 644966003525 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 644966003526 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 644966003527 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 644966003528 Ligand Binding Site [chemical binding]; other site 644966003529 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644966003530 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 644966003531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966003532 catalytic residue [active] 644966003533 Predicted transcriptional regulator [Transcription]; Region: COG1959 644966003534 Helix-turn-helix domains; Region: HTH; cl00088 644966003535 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 644966003536 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 644966003537 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 644966003538 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 644966003539 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 644966003540 active site 644966003541 catalytic motif [active] 644966003542 Zn binding site [ion binding]; other site 644966003543 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 644966003544 intersubunit interface [polypeptide binding]; other site 644966003545 active site 644966003546 catalytic residue [active] 644966003547 thymidine kinase; Provisional; Region: PRK04296 644966003548 recombination factor protein RarA; Reviewed; Region: PRK13342 644966003549 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003550 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 644966003551 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 644966003552 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 644966003553 tetramer interface [polypeptide binding]; other site 644966003554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966003555 catalytic residue [active] 644966003556 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644966003557 catalytic residues [active] 644966003558 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 644966003559 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 644966003560 Dimer interface [polypeptide binding]; other site 644966003561 anticodon binding site; other site 644966003562 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 644966003563 homodimer interface [polypeptide binding]; other site 644966003564 motif 1; other site 644966003565 active site 644966003566 motif 2; other site 644966003567 GAD domain; Region: GAD; pfam02938 644966003568 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 644966003569 motif 3; other site 644966003570 histidyl-tRNA synthetase; Region: hisS; TIGR00442 644966003571 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 644966003572 dimer interface [polypeptide binding]; other site 644966003573 motif 1; other site 644966003574 active site 644966003575 motif 2; other site 644966003576 motif 3; other site 644966003577 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 644966003578 anticodon binding site; other site 644966003579 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 644966003580 putative active site [active] 644966003581 dimerization interface [polypeptide binding]; other site 644966003582 putative tRNAtyr binding site [nucleotide binding]; other site 644966003583 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 644966003584 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 644966003585 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 644966003586 synthetase active site [active] 644966003587 NTP binding site [chemical binding]; other site 644966003588 metal binding site [ion binding]; metal-binding site 644966003589 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 644966003590 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 644966003591 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 644966003592 DHH family; Region: DHH; pfam01368 644966003593 DHHA1 domain; Region: DHHA1; pfam02272 644966003594 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 644966003595 metal ion-dependent adhesion site (MIDAS); other site 644966003596 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 644966003597 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 644966003598 Protein export membrane protein; Region: SecD_SecF; cl14618 644966003599 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 644966003600 Protein export membrane protein; Region: SecD_SecF; cl14618 644966003601 H+ Antiporter protein; Region: 2A0121; TIGR00900 644966003602 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966003603 putative substrate translocation pore; other site 644966003604 Selenocysteine-specific translation elongation factor [Translation, ribosomal structure and biogenesis]; Region: SelB; COG3276 644966003605 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 644966003606 G1 box; other site 644966003607 putative GEF interaction site [polypeptide binding]; other site 644966003608 GTP/Mg2+ binding site [chemical binding]; other site 644966003609 Switch I region; other site 644966003610 G2 box; other site 644966003611 G3 box; other site 644966003612 Switch II region; other site 644966003613 G4 box; other site 644966003614 G5 box; other site 644966003615 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 644966003616 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 644966003617 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 644966003618 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 644966003619 active site 644966003620 Ap6A binding site [chemical binding]; other site 644966003621 nudix motif; other site 644966003622 metal binding site [ion binding]; metal-binding site 644966003623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644966003624 non-specific DNA binding site [nucleotide binding]; other site 644966003625 salt bridge; other site 644966003626 sequence-specific DNA binding site [nucleotide binding]; other site 644966003627 Helix-turn-helix domains; Region: HTH; cl00088 644966003628 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 644966003629 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 644966003630 FAD binding site [chemical binding]; other site 644966003631 homotetramer interface [polypeptide binding]; other site 644966003632 substrate binding pocket [chemical binding]; other site 644966003633 catalytic base [active] 644966003634 ArgK protein; Region: ArgK; pfam03308 644966003635 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 644966003636 Walker A; other site 644966003637 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 644966003638 B12 binding site [chemical binding]; other site 644966003639 cobalt ligand [ion binding]; other site 644966003640 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 644966003641 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 644966003642 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 644966003643 dimer interface [polypeptide binding]; other site 644966003644 active site 644966003645 Schiff base residues; other site 644966003646 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 644966003647 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 644966003648 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 644966003649 active site 644966003650 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 644966003651 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 644966003652 domain interfaces; other site 644966003653 active site 644966003654 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 644966003655 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 644966003656 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 644966003657 tRNA; other site 644966003658 putative tRNA binding site [nucleotide binding]; other site 644966003659 putative NADP binding site [chemical binding]; other site 644966003660 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 644966003661 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 644966003662 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966003663 S-adenosylmethionine binding site [chemical binding]; other site 644966003664 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 644966003665 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003666 CoA-ligase; Region: Ligase_CoA; cl02894 644966003667 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 644966003668 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966003669 CoA-ligase; Region: Ligase_CoA; cl02894 644966003670 Malic enzyme, N-terminal domain; Region: malic; pfam00390 644966003671 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 644966003672 putative NAD(P) binding site [chemical binding]; other site 644966003673 malate dehydrogenase; Reviewed; Region: PRK06223 644966003674 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 644966003675 NAD(P) binding site [chemical binding]; other site 644966003676 dimer interface [polypeptide binding]; other site 644966003677 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644966003678 substrate binding site [chemical binding]; other site 644966003679 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 644966003680 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 644966003681 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 644966003682 Walker A/P-loop; other site 644966003683 ATP binding site [chemical binding]; other site 644966003684 Q-loop/lid; other site 644966003685 ABC transporter signature motif; other site 644966003686 Walker B; other site 644966003687 D-loop; other site 644966003688 CcmB protein; Region: CcmB; cl01016 644966003689 CcmE; Region: CcmE; cl00994 644966003690 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 644966003691 stage V sporulation protein T; Region: spore_V_T; TIGR02851 644966003692 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 644966003693 GAF domain; Region: GAF; cl15785 644966003694 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 644966003695 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644966003696 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 644966003697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966003698 catalytic residue [active] 644966003699 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 644966003700 THUMP domain; Region: THUMP; cl12076 644966003701 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 644966003702 Ligand Binding Site [chemical binding]; other site 644966003703 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 644966003704 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 644966003705 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 644966003706 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 644966003707 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966003708 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 644966003709 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 644966003710 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003711 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 644966003712 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 644966003713 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966003714 Protein of unknown function DUF45; Region: DUF45; cl00636 644966003715 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966003716 Helix-turn-helix domains; Region: HTH; cl00088 644966003717 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 644966003718 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 644966003719 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 644966003720 Sugar fermentation stimulation protein; Region: SfsA; cl00647 644966003721 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 644966003722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 644966003723 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644966003724 putative active site [active] 644966003725 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 644966003726 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 644966003727 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 644966003728 NAD(P) binding site [chemical binding]; other site 644966003729 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 644966003730 AMP-binding enzyme; Region: AMP-binding; cl15778 644966003731 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966003732 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 644966003733 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 644966003734 active site 644966003735 nucleophile elbow; other site 644966003736 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 644966003737 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 644966003738 Spore germination protein; Region: Spore_permease; cl15802 644966003739 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 644966003740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966003741 putative substrate translocation pore; other site 644966003742 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 644966003743 dimer interface [polypeptide binding]; other site 644966003744 Citrate synthase; Region: Citrate_synt; pfam00285 644966003745 active site 644966003746 citrylCoA binding site [chemical binding]; other site 644966003747 oxalacetate/citrate binding site [chemical binding]; other site 644966003748 coenzyme A binding site [chemical binding]; other site 644966003749 catalytic triad [active] 644966003750 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 644966003751 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 644966003752 Walker A/P-loop; other site 644966003753 ATP binding site [chemical binding]; other site 644966003754 Q-loop/lid; other site 644966003755 ABC transporter signature motif; other site 644966003756 Walker B; other site 644966003757 D-loop; other site 644966003758 H-loop/switch region; other site 644966003759 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644966003760 putative PBP binding regions; other site 644966003761 ABC-ATPase subunit interface; other site 644966003762 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 644966003763 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 644966003764 cobalamin binding residues [chemical binding]; other site 644966003765 putative BtuC binding residues; other site 644966003766 dimer interface [polypeptide binding]; other site 644966003767 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 644966003768 active site 644966003769 FMN binding site [chemical binding]; other site 644966003770 substrate binding site [chemical binding]; other site 644966003771 homotetramer interface [polypeptide binding]; other site 644966003772 catalytic residue [active] 644966003773 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 644966003774 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 644966003775 active site 644966003776 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 644966003777 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 644966003778 NAD binding site [chemical binding]; other site 644966003779 homotetramer interface [polypeptide binding]; other site 644966003780 homodimer interface [polypeptide binding]; other site 644966003781 substrate binding site [chemical binding]; other site 644966003782 active site 644966003783 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644966003784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003785 Walker A/P-loop; other site 644966003786 ATP binding site [chemical binding]; other site 644966003787 Q-loop/lid; other site 644966003788 ABC transporter signature motif; other site 644966003789 Walker B; other site 644966003790 D-loop; other site 644966003791 H-loop/switch region; other site 644966003792 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 644966003793 Transposase, Mutator family; Region: Transposase_mut; pfam00872 644966003794 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 644966003795 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 644966003796 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 644966003797 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 644966003798 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644966003799 Helix-turn-helix domains; Region: HTH; cl00088 644966003800 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 644966003801 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 644966003802 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 644966003803 active site 644966003804 DNA binding site [nucleotide binding] 644966003805 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 644966003806 ligand binding site [chemical binding]; other site 644966003807 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 644966003808 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003809 Walker A/P-loop; other site 644966003810 ATP binding site [chemical binding]; other site 644966003811 Q-loop/lid; other site 644966003812 ABC transporter signature motif; other site 644966003813 Walker B; other site 644966003814 D-loop; other site 644966003815 H-loop/switch region; other site 644966003816 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 644966003817 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 644966003818 TM-ABC transporter signature motif; other site 644966003819 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 644966003820 TM-ABC transporter signature motif; other site 644966003821 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 644966003822 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 644966003823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966003824 Walker A/P-loop; other site 644966003825 ATP binding site [chemical binding]; other site 644966003826 Q-loop/lid; other site 644966003827 ABC transporter signature motif; other site 644966003828 Walker B; other site 644966003829 D-loop; other site 644966003830 H-loop/switch region; other site 644966003831 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 644966003832 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 644966003833 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 644966003834 Walker A/P-loop; other site 644966003835 ATP binding site [chemical binding]; other site 644966003836 Q-loop/lid; other site 644966003837 ABC transporter signature motif; other site 644966003838 Walker B; other site 644966003839 D-loop; other site 644966003840 H-loop/switch region; other site 644966003841 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 644966003842 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 644966003843 DNA binding site [nucleotide binding] 644966003844 active site 644966003845 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 644966003846 putative active site [active] 644966003847 putative metal binding site [ion binding]; other site 644966003848 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 644966003849 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644966003850 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 644966003851 Walker A/P-loop; other site 644966003852 ATP binding site [chemical binding]; other site 644966003853 Q-loop/lid; other site 644966003854 ABC transporter signature motif; other site 644966003855 Walker B; other site 644966003856 D-loop; other site 644966003857 H-loop/switch region; other site 644966003858 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644966003859 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 644966003860 Walker A/P-loop; other site 644966003861 ATP binding site [chemical binding]; other site 644966003862 Q-loop/lid; other site 644966003863 ABC transporter signature motif; other site 644966003864 Walker B; other site 644966003865 D-loop; other site 644966003866 H-loop/switch region; other site 644966003867 Cobalt transport protein; Region: CbiQ; cl00463 644966003868 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 644966003869 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 644966003870 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003871 NAD(P) binding site [chemical binding]; other site 644966003872 active site 644966003873 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 644966003874 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 644966003875 active site 644966003876 Predicted aminoglycoside phosphotransferase [General function prediction only]; Region: COG3173 644966003877 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 644966003878 putative active site [active] 644966003879 putative substrate binding site [chemical binding]; other site 644966003880 ATP binding site [chemical binding]; other site 644966003881 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 644966003882 DinB superfamily; Region: DinB_2; pfam12867 644966003883 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 644966003884 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 644966003885 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 644966003886 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 644966003887 putative active site [active] 644966003888 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 644966003889 active site 644966003890 Zn binding site [ion binding]; other site 644966003891 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 644966003892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966003893 dimer interface [polypeptide binding]; other site 644966003894 conserved gate region; other site 644966003895 putative PBP binding loops; other site 644966003896 ABC-ATPase subunit interface; other site 644966003897 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966003898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966003899 dimer interface [polypeptide binding]; other site 644966003900 conserved gate region; other site 644966003901 putative PBP binding loops; other site 644966003902 ABC-ATPase subunit interface; other site 644966003903 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 644966003904 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966003905 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 644966003906 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966003907 Walker A/P-loop; other site 644966003908 ATP binding site [chemical binding]; other site 644966003909 Q-loop/lid; other site 644966003910 ABC transporter signature motif; other site 644966003911 Walker B; other site 644966003912 D-loop; other site 644966003913 H-loop/switch region; other site 644966003914 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966003915 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966003916 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966003917 Walker A/P-loop; other site 644966003918 ATP binding site [chemical binding]; other site 644966003919 Q-loop/lid; other site 644966003920 ABC transporter signature motif; other site 644966003921 Walker B; other site 644966003922 D-loop; other site 644966003923 H-loop/switch region; other site 644966003924 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966003925 Transcriptional regulator [Transcription]; Region: IclR; COG1414 644966003926 Helix-turn-helix domains; Region: HTH; cl00088 644966003927 Bacterial transcriptional regulator; Region: IclR; pfam01614 644966003928 hypothetical protein; Provisional; Region: PRK05858 644966003929 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644966003930 dimer interface [polypeptide binding]; other site 644966003931 PYR/PP interface [polypeptide binding]; other site 644966003932 TPP binding site [chemical binding]; other site 644966003933 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 644966003934 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 644966003935 TPP-binding site; other site 644966003936 dimer interface [polypeptide binding]; other site 644966003937 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 644966003938 AMP-binding enzyme; Region: AMP-binding; cl15778 644966003939 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966003940 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 644966003941 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644966003942 active site 644966003943 metal binding site [ion binding]; metal-binding site 644966003944 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 644966003945 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966003946 active site 644966003947 motif I; other site 644966003948 motif II; other site 644966003949 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644966003950 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644966003951 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966003952 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966003953 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966003954 active site 644966003955 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966003956 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 644966003957 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966003958 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 644966003959 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 644966003960 Sulphur transport; Region: Sulf_transp; cl01018 644966003961 putative inner membrane protein; Provisional; Region: PRK11099 644966003962 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 644966003963 CPxP motif; other site 644966003964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 644966003965 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966003966 dimer interface [polypeptide binding]; other site 644966003967 phosphorylation site [posttranslational modification] 644966003968 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966003969 ATP binding site [chemical binding]; other site 644966003970 Mg2+ binding site [ion binding]; other site 644966003971 G-X-G motif; other site 644966003972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644966003973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966003974 active site 644966003975 phosphorylation site [posttranslational modification] 644966003976 intermolecular recognition site; other site 644966003977 dimerization interface [polypeptide binding]; other site 644966003978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966003979 DNA binding site [nucleotide binding] 644966003980 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 644966003981 Moco binding site; other site 644966003982 metal coordination site [ion binding]; other site 644966003983 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 644966003984 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 644966003985 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966003986 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 644966003987 active site 644966003988 ATP binding site [chemical binding]; other site 644966003989 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 644966003990 Ligand Binding Site [chemical binding]; other site 644966003991 acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase; Region: DapE-ArgE; TIGR01910 644966003992 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 644966003993 metal binding site [ion binding]; metal-binding site 644966003994 dimer interface [polypeptide binding]; other site 644966003995 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 644966003996 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 644966003997 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 644966003998 general stress protein 13; Validated; Region: PRK08059 644966003999 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 644966004000 RNA binding site [nucleotide binding]; other site 644966004001 stage V sporulation protein B; Region: spore_V_B; TIGR02900 644966004002 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 644966004003 active site 644966004004 dimer interfaces [polypeptide binding]; other site 644966004005 catalytic residues [active] 644966004006 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 644966004007 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 644966004008 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 644966004009 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 644966004010 dimer interface [polypeptide binding]; other site 644966004011 PYR/PP interface [polypeptide binding]; other site 644966004012 TPP binding site [chemical binding]; other site 644966004013 substrate binding site [chemical binding]; other site 644966004014 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 644966004015 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 644966004016 TPP-binding site [chemical binding]; other site 644966004017 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 644966004018 DinB superfamily; Region: DinB_2; pfam12867 644966004019 Protein of unknown function DUF84; Region: NTPase_I-T; cl00866 644966004020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644966004021 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966004022 active site 644966004023 phosphorylation site [posttranslational modification] 644966004024 intermolecular recognition site; other site 644966004025 dimerization interface [polypeptide binding]; other site 644966004026 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644966004027 DNA binding residues [nucleotide binding] 644966004028 dimerization interface [polypeptide binding]; other site 644966004029 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 644966004030 Histidine kinase; Region: HisKA_3; pfam07730 644966004031 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 644966004032 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966004033 ATP binding site [chemical binding]; other site 644966004034 Mg2+ binding site [ion binding]; other site 644966004035 G-X-G motif; other site 644966004036 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 644966004037 AzlC protein; Region: AzlC; cl00570 644966004038 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 644966004039 nudix motif; other site 644966004040 Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624 644966004041 M20 Peptidases, Poly(aspartic acid) hydrolase-like proteins; Region: M20_PAAh_like; cd03896 644966004042 putative metal binding site [ion binding]; other site 644966004043 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 644966004044 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 644966004045 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 644966004046 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 644966004047 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644966004048 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 644966004049 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 644966004050 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 644966004051 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 644966004052 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 644966004053 dimerization interface [polypeptide binding]; other site 644966004054 ligand binding site [chemical binding]; other site 644966004055 Bacterial SH3 domain; Region: SH3_3; cl02551 644966004056 Response regulator receiver domain; Region: Response_reg; pfam00072 644966004057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966004058 active site 644966004059 phosphorylation site [posttranslational modification] 644966004060 intermolecular recognition site; other site 644966004061 dimerization interface [polypeptide binding]; other site 644966004062 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 644966004063 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 644966004064 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 644966004065 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 644966004066 carboxyltransferase (CT) interaction site; other site 644966004067 biotinylation site [posttranslational modification]; other site 644966004068 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 644966004069 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 644966004070 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 644966004071 RNA binding surface [nucleotide binding]; other site 644966004072 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 644966004073 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 644966004074 homodimer interface [polypeptide binding]; other site 644966004075 substrate-cofactor binding pocket; other site 644966004076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966004077 catalytic residue [active] 644966004078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004079 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 644966004080 homodecamer interface [polypeptide binding]; other site 644966004081 GTP cyclohydrolase I; Provisional; Region: PLN03044 644966004082 active site 644966004083 putative catalytic site residues [active] 644966004084 zinc binding site [ion binding]; other site 644966004085 GTP-CH-I/GFRP interaction surface; other site 644966004086 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 644966004087 catalytic residues [active] 644966004088 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 644966004089 malate synthase A; Region: malate_syn_A; TIGR01344 644966004090 active site 644966004091 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 644966004092 FAD binding domain; Region: FAD_binding_4; pfam01565 644966004093 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 644966004094 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 644966004095 Cysteine-rich domain; Region: CCG; pfam02754 644966004096 Cysteine-rich domain; Region: CCG; pfam02754 644966004097 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 644966004098 FAD binding domain; Region: FAD_binding_4; pfam01565 644966004099 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 644966004100 FAD binding domain; Region: FAD_binding_4; pfam01565 644966004101 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 644966004102 active site 644966004103 Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561 644966004104 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 644966004105 putative active site [active] 644966004106 catalytic site [active] 644966004107 putative metal binding site [ion binding]; other site 644966004108 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 644966004109 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 644966004110 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 644966004111 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 644966004112 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 644966004113 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 644966004114 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644966004115 catalytic loop [active] 644966004116 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 644966004117 iron binding site [ion binding]; other site 644966004118 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 644966004119 enoyl-CoA hydratase; Provisional; Region: PRK05862 644966004120 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966004121 substrate binding site [chemical binding]; other site 644966004122 oxyanion hole (OAH) forming residues; other site 644966004123 trimer interface [polypeptide binding]; other site 644966004124 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 644966004125 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 644966004126 cobalamin binding residues [chemical binding]; other site 644966004127 putative BtuC binding residues; other site 644966004128 dimer interface [polypeptide binding]; other site 644966004129 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 644966004130 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 644966004131 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644966004132 FeS/SAM binding site; other site 644966004133 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 644966004134 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 644966004135 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 644966004136 NodB motif; other site 644966004137 active site 644966004138 catalytic site [active] 644966004139 metal binding site [ion binding]; metal-binding site 644966004140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644966004141 Helix-turn-helix domains; Region: HTH; cl00088 644966004142 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 644966004143 Lumazine binding domain; Region: Lum_binding; pfam00677 644966004144 Lumazine binding domain; Region: Lum_binding; pfam00677 644966004145 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 644966004146 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 644966004147 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 644966004148 dimerization interface [polypeptide binding]; other site 644966004149 active site 644966004150 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 644966004151 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966004152 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 644966004153 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 644966004154 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 644966004155 purine monophosphate binding site [chemical binding]; other site 644966004156 dimer interface [polypeptide binding]; other site 644966004157 putative catalytic residues [active] 644966004158 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 644966004159 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 644966004160 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 644966004161 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 644966004162 active site 644966004163 substrate binding site [chemical binding]; other site 644966004164 cosubstrate binding site; other site 644966004165 catalytic site [active] 644966004166 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 644966004167 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 644966004168 dimerization interface [polypeptide binding]; other site 644966004169 putative ATP binding site [chemical binding]; other site 644966004170 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 644966004171 Glutamine amidotransferases class-II; Region: GATase_2; pfam00310 644966004172 active site 644966004173 amidophosphoribosyltransferase; Region: purF; TIGR01134 644966004174 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 644966004175 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 644966004176 dimerization interface [polypeptide binding]; other site 644966004177 ATP binding site [chemical binding]; other site 644966004178 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 644966004179 dimerization interface [polypeptide binding]; other site 644966004180 ATP binding site [chemical binding]; other site 644966004181 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 644966004182 conserved cys residue [active] 644966004183 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 644966004184 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 644966004185 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 644966004186 ATP binding site [chemical binding]; other site 644966004187 active site 644966004188 substrate binding site [chemical binding]; other site 644966004189 adenylosuccinate lyase; Provisional; Region: PRK07492 644966004190 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 644966004191 tetramer interface [polypeptide binding]; other site 644966004192 active site 644966004193 AIR carboxylase; Region: AIRC; cl00310 644966004194 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 644966004195 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 644966004196 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 644966004197 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 644966004198 active site 644966004199 catalytic residues [active] 644966004200 metal binding site [ion binding]; metal-binding site 644966004201 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 644966004202 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 644966004203 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 644966004204 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 644966004205 TPP-binding site [chemical binding]; other site 644966004206 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 644966004207 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 644966004208 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 644966004209 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 644966004210 dimer interface [polypeptide binding]; other site 644966004211 PYR/PP interface [polypeptide binding]; other site 644966004212 TPP binding site [chemical binding]; other site 644966004213 substrate binding site [chemical binding]; other site 644966004214 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644966004215 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 644966004216 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644966004217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644966004218 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644966004219 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 644966004220 Walker A/P-loop; other site 644966004221 ATP binding site [chemical binding]; other site 644966004222 Q-loop/lid; other site 644966004223 ABC transporter signature motif; other site 644966004224 Walker B; other site 644966004225 D-loop; other site 644966004226 H-loop/switch region; other site 644966004227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004228 dimer interface [polypeptide binding]; other site 644966004229 conserved gate region; other site 644966004230 putative PBP binding loops; other site 644966004231 ABC-ATPase subunit interface; other site 644966004232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644966004233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004234 putative PBP binding loops; other site 644966004235 dimer interface [polypeptide binding]; other site 644966004236 ABC-ATPase subunit interface; other site 644966004237 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 644966004238 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644966004239 substrate binding pocket [chemical binding]; other site 644966004240 membrane-bound complex binding site; other site 644966004241 hinge residues; other site 644966004242 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004243 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 644966004244 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 644966004245 aromatic arch; other site 644966004246 DCoH dimer interaction site [polypeptide binding]; other site 644966004247 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 644966004248 DCoH tetramer interaction site [polypeptide binding]; other site 644966004249 substrate binding site [chemical binding]; other site 644966004250 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 644966004251 CoenzymeA binding site [chemical binding]; other site 644966004252 subunit interaction site [polypeptide binding]; other site 644966004253 PHB binding site; other site 644966004254 PUA domain; Region: PUA; cl00607 644966004255 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 644966004256 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 644966004257 putative RNA binding site [nucleotide binding]; other site 644966004258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966004259 S-adenosylmethionine binding site [chemical binding]; other site 644966004260 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004261 TIGR01777 family protein; Region: yfcH 644966004262 NAD(P) binding site [chemical binding]; other site 644966004263 active site 644966004264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966004265 putative substrate translocation pore; other site 644966004266 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966004267 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 644966004268 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 644966004269 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 644966004270 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 644966004271 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 644966004272 putative metal binding site [ion binding]; other site 644966004273 tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111 644966004274 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 644966004275 substrate binding site [chemical binding]; other site 644966004276 active site 644966004277 catalytic residues [active] 644966004278 heterodimer interface [polypeptide binding]; other site 644966004279 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 644966004280 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 644966004281 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966004282 catalytic residue [active] 644966004283 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 644966004284 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 644966004285 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 644966004286 active site 644966004287 ribulose/triose binding site [chemical binding]; other site 644966004288 phosphate binding site [ion binding]; other site 644966004289 substrate (anthranilate) binding pocket [chemical binding]; other site 644966004290 product (indole) binding pocket [chemical binding]; other site 644966004291 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 644966004292 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 644966004293 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 644966004294 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 644966004295 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 644966004296 glutamine binding [chemical binding]; other site 644966004297 catalytic triad [active] 644966004298 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 644966004299 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 644966004300 chorismate binding enzyme; Region: Chorismate_bind; cl10555 644966004301 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 644966004302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644966004303 protein binding site [polypeptide binding]; other site 644966004304 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 644966004305 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 644966004306 molybdopterin cofactor binding site; other site 644966004307 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 644966004308 molybdopterin cofactor binding site; other site 644966004309 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 644966004310 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 644966004311 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 644966004312 GTP binding site; other site 644966004313 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 644966004314 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 644966004315 NAD(P) binding site [chemical binding]; other site 644966004316 Transcriptional regulator [Transcription]; Region: IclR; COG1414 644966004317 Helix-turn-helix domains; Region: HTH; cl00088 644966004318 Bacterial transcriptional regulator; Region: IclR; pfam01614 644966004319 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_5; cd08511 644966004320 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966004321 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966004322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004323 dimer interface [polypeptide binding]; other site 644966004324 conserved gate region; other site 644966004325 putative PBP binding loops; other site 644966004326 ABC-ATPase subunit interface; other site 644966004327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004328 dimer interface [polypeptide binding]; other site 644966004329 conserved gate region; other site 644966004330 putative PBP binding loops; other site 644966004331 ABC-ATPase subunit interface; other site 644966004332 Chromate transporter; Region: Chromate_transp; pfam02417 644966004333 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 644966004334 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 644966004335 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966004336 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966004337 Walker A/P-loop; other site 644966004338 ATP binding site [chemical binding]; other site 644966004339 Q-loop/lid; other site 644966004340 ABC transporter signature motif; other site 644966004341 Walker B; other site 644966004342 D-loop; other site 644966004343 H-loop/switch region; other site 644966004344 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966004345 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 644966004346 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966004347 Walker A/P-loop; other site 644966004348 ATP binding site [chemical binding]; other site 644966004349 Q-loop/lid; other site 644966004350 ABC transporter signature motif; other site 644966004351 Walker B; other site 644966004352 D-loop; other site 644966004353 H-loop/switch region; other site 644966004354 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966004355 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 644966004356 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 644966004357 putative substrate binding site [chemical binding]; other site 644966004358 nucleotide binding site [chemical binding]; other site 644966004359 nucleotide binding site [chemical binding]; other site 644966004360 homodimer interface [polypeptide binding]; other site 644966004361 Putative cyclase; Region: Cyclase; cl00814 644966004362 uracil transporter; Provisional; Region: PRK10720 644966004363 membrane protein FdrA; Validated; Region: PRK06091 644966004364 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004365 membrane protein FdrA; Validated; Region: PRK06091 644966004366 CoA-ligase; Region: Ligase_CoA; cl02894 644966004367 membrane protein FdrA; Validated; Region: PRK06091 644966004368 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 644966004369 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644966004370 Na binding site [ion binding]; other site 644966004371 cytosine deaminase; Provisional; Region: PRK09230 644966004372 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 644966004373 active site 644966004374 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 644966004375 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 644966004376 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 644966004377 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 644966004378 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 644966004379 catalytic loop [active] 644966004380 iron binding site [ion binding]; other site 644966004381 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 644966004382 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 644966004383 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 644966004384 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 644966004385 Helix-turn-helix domains; Region: HTH; cl00088 644966004386 enoyl-CoA hydratase; Provisional; Region: PRK06144 644966004387 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966004388 substrate binding site [chemical binding]; other site 644966004389 oxyanion hole (OAH) forming residues; other site 644966004390 trimer interface [polypeptide binding]; other site 644966004391 acetyl-CoA synthetase; Provisional; Region: PRK00174 644966004392 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 644966004393 AMP-binding enzyme; Region: AMP-binding; cl15778 644966004394 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966004395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966004396 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644966004397 putative substrate translocation pore; other site 644966004398 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 644966004399 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 644966004400 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 644966004401 dimer interface [polypeptide binding]; other site 644966004402 PYR/PP interface [polypeptide binding]; other site 644966004403 TPP binding site [chemical binding]; other site 644966004404 substrate binding site [chemical binding]; other site 644966004405 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 644966004406 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 644966004407 TPP-binding site [chemical binding]; other site 644966004408 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 644966004409 Uncharacterized conserved protein (DUF2267); Region: DUF2267; cl02314 644966004410 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 644966004411 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 644966004412 XdhC Rossmann domain; Region: XdhC_C; pfam13478 644966004413 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 644966004414 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 644966004415 putative hydrophobic ligand binding site [chemical binding]; other site 644966004416 carbon-monoxide dehydrogenase, large subunit; Region: CO_dehy_Mo_lg; TIGR02416 644966004417 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 644966004418 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 644966004419 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 644966004420 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 644966004421 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 644966004422 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 644966004423 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 644966004424 Protein of unknown function (DUF1696); Region: DUF1696; pfam08000 644966004425 Domain of unknown function DUF59; Region: DUF59; cl00941 644966004426 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 644966004427 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 644966004428 Walker A/P-loop; other site 644966004429 ATP binding site [chemical binding]; other site 644966004430 Q-loop/lid; other site 644966004431 ABC transporter signature motif; other site 644966004432 Walker B; other site 644966004433 D-loop; other site 644966004434 H-loop/switch region; other site 644966004435 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 644966004436 CPxP motif; other site 644966004437 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 644966004438 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 644966004439 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 644966004440 DXD motif; other site 644966004441 Peptidase family M23; Region: Peptidase_M23; pfam01551 644966004442 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 644966004443 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004444 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004445 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 644966004446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644966004447 FeS/SAM binding site; other site 644966004448 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 644966004449 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 644966004450 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004451 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004452 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 644966004453 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 644966004454 4Fe-4S binding domain; Region: Fer4; cl02805 644966004455 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 644966004456 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 644966004457 ligand binding site [chemical binding]; other site 644966004458 flexible hinge region; other site 644966004459 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 644966004460 non-specific DNA interactions [nucleotide binding]; other site 644966004461 DNA binding site [nucleotide binding] 644966004462 sequence specific DNA binding site [nucleotide binding]; other site 644966004463 putative cAMP binding site [chemical binding]; other site 644966004464 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 644966004465 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 644966004466 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 644966004467 NAD(P) binding site [chemical binding]; other site 644966004468 catalytic residues [active] 644966004469 Ribonucleotide Reductase R2-like protein, Mn/Fe-binding domain; Region: RNRR2_Rv0233_like; cd07911 644966004470 active site 644966004471 diiron metal binding site [ion binding]; other site 644966004472 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 2; Region: FDH_like_2; cd08284 644966004473 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 644966004474 catalytic Zn binding site [ion binding]; other site 644966004475 NAD(P) binding site [chemical binding]; other site 644966004476 structural Zn binding site [ion binding]; other site 644966004477 SCP-2 sterol transfer family; Region: SCP2; cl01225 644966004478 Helix-turn-helix domains; Region: HTH; cl00088 644966004479 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 644966004480 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 644966004481 Ligand binding site; other site 644966004482 metal-binding site 644966004483 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 644966004484 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966004485 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 644966004486 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 644966004487 XdhC Rossmann domain; Region: XdhC_C; pfam13478 644966004488 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966004489 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 644966004490 Walker A motif; other site 644966004491 ATP binding site [chemical binding]; other site 644966004492 Walker B motif; other site 644966004493 arginine finger; other site 644966004494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644966004495 putative DNA binding site [nucleotide binding]; other site 644966004496 dimerization interface [polypeptide binding]; other site 644966004497 putative Zn2+ binding site [ion binding]; other site 644966004498 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 644966004499 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644966004500 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966004501 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644966004502 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644966004503 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644966004504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004505 dimer interface [polypeptide binding]; other site 644966004506 conserved gate region; other site 644966004507 putative PBP binding loops; other site 644966004508 ABC-ATPase subunit interface; other site 644966004509 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644966004510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004511 dimer interface [polypeptide binding]; other site 644966004512 conserved gate region; other site 644966004513 putative PBP binding loops; other site 644966004514 ABC-ATPase subunit interface; other site 644966004515 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 644966004516 active site 644966004517 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 644966004518 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 644966004519 Beta-galactosidase; Region: Glyco_hydro_42; cl03154 644966004520 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl15381 644966004521 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 644966004522 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 644966004523 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 644966004524 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644966004525 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644966004526 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 644966004527 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 644966004528 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966004529 Walker A/P-loop; other site 644966004530 ATP binding site [chemical binding]; other site 644966004531 Q-loop/lid; other site 644966004532 ABC transporter signature motif; other site 644966004533 Walker B; other site 644966004534 D-loop; other site 644966004535 H-loop/switch region; other site 644966004536 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 644966004537 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 644966004538 Predicted membrane protein [Function unknown]; Region: COG1511 644966004539 ABC-2 type transporter; Region: ABC2_membrane; cl11417 644966004540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644966004541 Helix-turn-helix domains; Region: HTH; cl00088 644966004542 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 644966004543 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004544 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 644966004545 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 644966004546 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 644966004547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644966004548 sequence-specific DNA binding site [nucleotide binding]; other site 644966004549 salt bridge; other site 644966004550 Cupin domain; Region: Cupin_2; cl09118 644966004551 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644966004552 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 644966004553 active site 644966004554 motif I; other site 644966004555 motif II; other site 644966004556 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966004557 Protein of unknown function (DUF1341); Region: DUF1341; cl06211 644966004558 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644966004559 Domain of unknown function (DUF4310); Region: DUF4310; cl11918 644966004560 Domain of unknown function (DUF4311); Region: DUF4311; cl11919 644966004561 Domain of unknown function (DUF4312); Region: DUF4312; cl11917 644966004562 Glycine-rich SFCGS; Region: Gly_rich_SFCGS; cl11916 644966004563 PRD domain; Region: PRD; cl15445 644966004564 dihydroorotase; Provisional; Region: PRK09237 644966004565 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966004566 active site 644966004567 Helix-turn-helix domains; Region: HTH; cl00088 644966004568 PRD domain; Region: PRD; cl15445 644966004569 PRD domain; Region: PRD; cl15445 644966004570 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 644966004571 active site 644966004572 P-loop; other site 644966004573 phosphorylation site [posttranslational modification] 644966004574 PRD domain; Region: PRD; cl15445 644966004575 CAAX protease self-immunity; Region: Abi; cl00558 644966004576 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004577 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 644966004578 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 644966004579 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 644966004580 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644966004581 metal-binding site [ion binding] 644966004582 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644966004583 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966004584 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 644966004585 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966004586 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 644966004587 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966004588 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966004589 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 644966004590 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 644966004591 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 644966004592 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 644966004593 Predicted transcriptional regulator [Transcription]; Region: COG2378 644966004594 Helix-turn-helix domains; Region: HTH; cl00088 644966004595 WYL domain; Region: WYL; cl14852 644966004596 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 644966004597 dipeptidase PepV; Reviewed; Region: PRK07318 644966004598 active site 644966004599 metal binding site [ion binding]; metal-binding site 644966004600 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 644966004601 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 644966004602 Walker A/P-loop; other site 644966004603 ATP binding site [chemical binding]; other site 644966004604 Q-loop/lid; other site 644966004605 ABC transporter signature motif; other site 644966004606 Walker B; other site 644966004607 D-loop; other site 644966004608 H-loop/switch region; other site 644966004609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004610 dimer interface [polypeptide binding]; other site 644966004611 conserved gate region; other site 644966004612 putative PBP binding loops; other site 644966004613 ABC-ATPase subunit interface; other site 644966004614 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 644966004615 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 644966004616 substrate binding pocket [chemical binding]; other site 644966004617 membrane-bound complex binding site; other site 644966004618 hinge residues; other site 644966004619 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 644966004620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004622 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 644966004623 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644966004624 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966004625 catalytic residue [active] 644966004626 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 644966004627 CoA-transferase family III; Region: CoA_transf_3; pfam02515 644966004628 Uncharacterized conserved protein [Function unknown]; Region: COG4715 644966004629 SWIM zinc finger; Region: SWIM; cl15408 644966004630 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 644966004631 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 644966004632 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 644966004633 ATP binding site [chemical binding]; other site 644966004634 putative Mg++ binding site [ion binding]; other site 644966004635 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 644966004636 nucleotide binding region [chemical binding]; other site 644966004637 ATP-binding site [chemical binding]; other site 644966004638 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 644966004639 catalytic residues [active] 644966004640 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 644966004641 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644966004642 metal-binding site [ion binding] 644966004643 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 644966004644 putative homodimer interface [polypeptide binding]; other site 644966004645 putative homotetramer interface [polypeptide binding]; other site 644966004646 putative allosteric switch controlling residues; other site 644966004647 putative metal binding site [ion binding]; other site 644966004648 putative homodimer-homodimer interface [polypeptide binding]; other site 644966004649 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644966004650 metal-binding site [ion binding] 644966004651 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644966004652 metal-binding site [ion binding] 644966004653 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644966004654 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 644966004655 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966004656 VPS10 domain; Region: VPS10; smart00602 644966004657 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 644966004658 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 644966004659 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 644966004660 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644966004661 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966004662 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 644966004663 dimerization interface [polypeptide binding]; other site 644966004664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644966004665 dimerization interface [polypeptide binding]; other site 644966004666 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966004667 dimer interface [polypeptide binding]; other site 644966004668 phosphorylation site [posttranslational modification] 644966004669 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966004670 ATP binding site [chemical binding]; other site 644966004671 Mg2+ binding site [ion binding]; other site 644966004672 G-X-G motif; other site 644966004673 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644966004674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966004675 active site 644966004676 phosphorylation site [posttranslational modification] 644966004677 intermolecular recognition site; other site 644966004678 dimerization interface [polypeptide binding]; other site 644966004679 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966004680 DNA binding site [nucleotide binding] 644966004681 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004682 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004683 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004684 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 644966004685 catalytic residues [active] 644966004686 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 644966004687 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 644966004688 active site residue [active] 644966004689 UbiA prenyltransferase family; Region: UbiA; cl00337 644966004690 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004691 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 644966004692 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 644966004693 D-pathway; other site 644966004694 Low-spin heme binding site [chemical binding]; other site 644966004695 Putative water exit pathway; other site 644966004696 Binuclear center (active site) [active] 644966004697 K-pathway; other site 644966004698 Putative proton exit pathway; other site 644966004699 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 644966004700 Subunit I/III interface [polypeptide binding]; other site 644966004701 Peptidase family M48; Region: Peptidase_M48; cl12018 644966004702 Helix-turn-helix domains; Region: HTH; cl00088 644966004703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966004704 S-adenosylmethionine binding site [chemical binding]; other site 644966004705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966004706 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 644966004707 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644966004708 metal-binding site [ion binding] 644966004709 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644966004710 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966004711 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 644966004712 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 644966004713 DNA binding residues [nucleotide binding] 644966004714 dimer interface [polypeptide binding]; other site 644966004715 metal binding site [ion binding]; metal-binding site 644966004716 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644966004717 dimerization interface [polypeptide binding]; other site 644966004718 putative DNA binding site [nucleotide binding]; other site 644966004719 putative Zn2+ binding site [ion binding]; other site 644966004720 Alkylmercury lyase; Region: MerB; pfam03243 644966004721 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 644966004722 metal-binding site [ion binding] 644966004723 mercuric reductase; Region: MerA; TIGR02053 644966004724 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644966004725 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644966004726 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 644966004727 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966004728 dimer interface [polypeptide binding]; other site 644966004729 phosphorylation site [posttranslational modification] 644966004730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966004731 ATP binding site [chemical binding]; other site 644966004732 Mg2+ binding site [ion binding]; other site 644966004733 G-X-G motif; other site 644966004734 Short C-terminal domain; Region: SHOCT; cl01373 644966004735 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644966004736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966004737 active site 644966004738 phosphorylation site [posttranslational modification] 644966004739 intermolecular recognition site; other site 644966004740 dimerization interface [polypeptide binding]; other site 644966004741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966004742 DNA binding site [nucleotide binding] 644966004743 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 644966004744 AMP-binding enzyme; Region: AMP-binding; cl15778 644966004745 AMP-binding enzyme; Region: AMP-binding; cl15778 644966004746 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966004747 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 644966004748 Response regulator receiver domain; Region: Response_reg; pfam00072 644966004749 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966004750 active site 644966004751 phosphorylation site [posttranslational modification] 644966004752 intermolecular recognition site; other site 644966004753 dimerization interface [polypeptide binding]; other site 644966004754 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966004755 DNA binding site [nucleotide binding] 644966004756 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966004757 phosphorylation site [posttranslational modification] 644966004758 dimer interface [polypeptide binding]; other site 644966004759 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966004760 ATP binding site [chemical binding]; other site 644966004761 Mg2+ binding site [ion binding]; other site 644966004762 G-X-G motif; other site 644966004763 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644966004764 The BcrA subfamily represents ABC transporters involved in peptide antibiotic resistance. Bacitracin is a dodecapeptide antibiotic produced by B. licheniformis and B. subtilis. The synthesis of bacitracin is non-ribosomally catalyzed by a multienzyme...; Region: ABC_BcrA_bacitracin_resist; cd03268 644966004765 Walker A/P-loop; other site 644966004766 ATP binding site [chemical binding]; other site 644966004767 Q-loop/lid; other site 644966004768 ABC transporter signature motif; other site 644966004769 Walker B; other site 644966004770 D-loop; other site 644966004771 H-loop/switch region; other site 644966004772 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 644966004773 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 644966004774 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966004775 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 644966004776 substrate binding site [chemical binding]; other site 644966004777 oxyanion hole (OAH) forming residues; other site 644966004778 trimer interface [polypeptide binding]; other site 644966004779 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 644966004780 dimer interface [polypeptide binding]; other site 644966004781 tetramer interface [polypeptide binding]; other site 644966004782 PYR/PP interface [polypeptide binding]; other site 644966004783 TPP binding site [chemical binding]; other site 644966004784 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylic-acid synthase; Region: menD; TIGR00173 644966004785 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 644966004786 TPP-binding site; other site 644966004787 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695 644966004788 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 644966004789 chorismate binding enzyme; Region: Chorismate_bind; cl10555 644966004790 UbiA prenyltransferase family; Region: UbiA; cl00337 644966004791 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 644966004792 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 644966004793 FAD binding site [chemical binding]; other site 644966004794 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 644966004795 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 644966004796 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966004797 catalytic residue [active] 644966004798 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 644966004799 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 644966004800 THF binding site; other site 644966004801 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 644966004802 substrate binding site [chemical binding]; other site 644966004803 THF binding site; other site 644966004804 zinc-binding site [ion binding]; other site 644966004805 siroheme synthase; Provisional; Region: cysG; PRK10637 644966004806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004807 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 644966004808 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 644966004809 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 644966004810 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 644966004811 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 644966004812 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 644966004813 Active Sites [active] 644966004814 shikimate kinase; Reviewed; Region: aroK; PRK00131 644966004815 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027 644966004816 ligand-binding site [chemical binding]; other site 644966004817 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 644966004818 ATP-sulfurylase; Region: ATPS; cd00517 644966004819 active site 644966004820 HXXH motif; other site 644966004821 flexible loop; other site 644966004822 Isochorismatase family; Region: Isochorismatase; pfam00857 644966004823 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 644966004824 metal binding site [ion binding]; metal-binding site 644966004825 catalytic triad [active] 644966004826 conserved cis-peptide bond; other site 644966004827 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 644966004828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966004829 active site 644966004830 phosphorylation site [posttranslational modification] 644966004831 intermolecular recognition site; other site 644966004832 dimerization interface [polypeptide binding]; other site 644966004833 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966004834 DNA binding site [nucleotide binding] 644966004835 Peroxiredoxin (PRX) family; composed of the different classes of PRXs including many proteins originally known as bacterioferritin comigratory proteins (BCP), based on their electrophoretic mobility before their function was identified. PRXs are...; Region: PRX_family; cd02971 644966004836 catalytic triad [active] 644966004837 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 644966004838 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 644966004839 glycerol kinase; Provisional; Region: glpK; PRK00047 644966004840 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 644966004841 N- and C-terminal domain interface [polypeptide binding]; other site 644966004842 active site 644966004843 MgATP binding site [chemical binding]; other site 644966004844 catalytic site [active] 644966004845 metal binding site [ion binding]; metal-binding site 644966004846 glycerol binding site [chemical binding]; other site 644966004847 homotetramer interface [polypeptide binding]; other site 644966004848 homodimer interface [polypeptide binding]; other site 644966004849 FBP binding site [chemical binding]; other site 644966004850 protein IIAGlc interface [polypeptide binding]; other site 644966004851 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 644966004852 DAK2 domain; Region: Dak2; cl03685 644966004853 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 644966004854 Dak1 domain; Region: Dak1; pfam02733 644966004855 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 644966004856 amphipathic channel; other site 644966004857 Asn-Pro-Ala signature motifs; other site 644966004858 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 644966004859 Low molecular weight phosphatase family; Region: LMWPc; cd00115 644966004860 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 644966004861 active site 644966004862 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 644966004863 PhoU domain; Region: PhoU; pfam01895 644966004864 PhoU domain; Region: PhoU; pfam01895 644966004865 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 644966004866 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 644966004867 Walker A/P-loop; other site 644966004868 ATP binding site [chemical binding]; other site 644966004869 Q-loop/lid; other site 644966004870 ABC transporter signature motif; other site 644966004871 Walker B; other site 644966004872 D-loop; other site 644966004873 H-loop/switch region; other site 644966004874 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 644966004875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004876 dimer interface [polypeptide binding]; other site 644966004877 conserved gate region; other site 644966004878 putative PBP binding loops; other site 644966004879 ABC-ATPase subunit interface; other site 644966004880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966004881 dimer interface [polypeptide binding]; other site 644966004882 conserved gate region; other site 644966004883 putative PBP binding loops; other site 644966004884 ABC-ATPase subunit interface; other site 644966004885 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966004886 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 644966004887 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644966004888 dimerization interface [polypeptide binding]; other site 644966004889 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966004890 dimer interface [polypeptide binding]; other site 644966004891 phosphorylation site [posttranslational modification] 644966004892 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966004893 ATP binding site [chemical binding]; other site 644966004894 Mg2+ binding site [ion binding]; other site 644966004895 G-X-G motif; other site 644966004896 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412 644966004897 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 644966004898 CrcB-like protein; Region: CRCB; cl09114 644966004899 Integral membrane protein TerC family; Region: TerC; cl10468 644966004900 fumarate hydratase; Reviewed; Region: fumC; PRK00485 644966004901 Class II fumarases; Region: Fumarase_classII; cd01362 644966004902 active site 644966004903 tetramer interface [polypeptide binding]; other site 644966004904 OsmC-like protein; Region: OsmC; cl00767 644966004905 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966004906 Protein of unknown function (DUF421); Region: DUF421; cl00990 644966004907 Protein of unknown function (DUF1657); Region: DUF1657; pfam07870 644966004908 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 644966004909 catalytic motif [active] 644966004910 Zn binding site [ion binding]; other site 644966004911 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 644966004912 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966004913 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 644966004914 lipoyl synthase; Provisional; Region: PRK05481 644966004915 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644966004916 FeS/SAM binding site; other site 644966004917 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 644966004918 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 644966004919 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 644966004920 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 644966004921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966004922 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644966004923 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 644966004924 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 644966004925 E3 interaction surface; other site 644966004926 lipoyl attachment site [posttranslational modification]; other site 644966004927 e3 binding domain; Region: E3_binding; pfam02817 644966004928 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 644966004929 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 644966004930 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 644966004931 alpha subunit interface [polypeptide binding]; other site 644966004932 TPP binding site [chemical binding]; other site 644966004933 heterodimer interface [polypeptide binding]; other site 644966004934 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644966004935 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 644966004936 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 644966004937 TPP-binding site [chemical binding]; other site 644966004938 tetramer interface [polypeptide binding]; other site 644966004939 heterodimer interface [polypeptide binding]; other site 644966004940 phosphorylation loop region [posttranslational modification] 644966004941 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 644966004942 NodB motif; other site 644966004943 putative active site [active] 644966004944 putative catalytic site [active] 644966004945 putative Zn binding site [ion binding]; other site 644966004946 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 644966004947 Divergent PAP2 family; Region: DUF212; cl00855 644966004948 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 644966004949 Helix-turn-helix domains; Region: HTH; cl00088 644966004950 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966004951 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 644966004952 Walker A/P-loop; other site 644966004953 ATP binding site [chemical binding]; other site 644966004954 Q-loop/lid; other site 644966004955 ABC transporter signature motif; other site 644966004956 Walker B; other site 644966004957 D-loop; other site 644966004958 H-loop/switch region; other site 644966004959 ABC-2 type transporter; Region: ABC2_membrane; cl11417 644966004960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966004961 putative substrate translocation pore; other site 644966004962 Major Facilitator Superfamily; Region: MFS_1; pfam07690 644966004963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966004964 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 644966004965 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 644966004966 CoenzymeA binding site [chemical binding]; other site 644966004967 subunit interaction site [polypeptide binding]; other site 644966004968 PHB binding site; other site 644966004969 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 644966004970 aconitate hydratase; Validated; Region: PRK09277 644966004971 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 644966004972 substrate binding site [chemical binding]; other site 644966004973 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 644966004974 ligand binding site [chemical binding]; other site 644966004975 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 644966004976 substrate binding site [chemical binding]; other site 644966004977 Protein of unknown function (DUF419); Region: DUF419; cl15265 644966004978 Indolepyruvate ferredoxin oxidoreductase, alpha and beta subunits [Energy production and conversion]; Region: COG4231 644966004979 4Fe-4S binding domain; Region: Fer4; cl02805 644966004980 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 644966004981 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 644966004982 oligomer interface [polypeptide binding]; other site 644966004983 active site 644966004984 metal binding site [ion binding]; metal-binding site 644966004985 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 644966004986 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 644966004987 oligomer interface [polypeptide binding]; other site 644966004988 active site 644966004989 metal binding site [ion binding]; metal-binding site 644966004990 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 644966004991 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 644966004992 oligomer interface [polypeptide binding]; other site 644966004993 active site 644966004994 metal binding site [ion binding]; metal-binding site 644966004995 CAT RNA binding domain; Region: CAT_RBD; cl03904 644966004996 transcriptional antiterminator BglG; Provisional; Region: PRK09772 644966004997 PRD domain; Region: PRD; cl15445 644966004998 PRD domain; Region: PRD; cl15445 644966004999 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 644966005000 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 644966005001 HPr interaction site; other site 644966005002 glycerol kinase (GK) interaction site [polypeptide binding]; other site 644966005003 active site 644966005004 phosphorylation site [posttranslational modification] 644966005005 Putative cyclase; Region: Cyclase; cl00814 644966005006 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 644966005007 Fungalysin metallopeptidase (M36); Region: Peptidase_M36; pfam02128 644966005008 Peptidase M36 family also known as fungalysin family; Region: M36; cd09596 644966005009 Zn binding site [ion binding]; other site 644966005010 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383 644966005011 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 644966005012 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 644966005013 Helix-turn-helix domains; Region: HTH; cl00088 644966005014 3H domain; Region: 3H; pfam02829 644966005015 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 644966005016 NlpC/P60 family; Region: NLPC_P60; cl11438 644966005017 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966005018 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966005019 Walker A/P-loop; other site 644966005020 ATP binding site [chemical binding]; other site 644966005021 Q-loop/lid; other site 644966005022 ABC transporter signature motif; other site 644966005023 Walker B; other site 644966005024 D-loop; other site 644966005025 H-loop/switch region; other site 644966005026 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966005027 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 644966005028 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966005029 Walker A/P-loop; other site 644966005030 ATP binding site [chemical binding]; other site 644966005031 Q-loop/lid; other site 644966005032 ABC transporter signature motif; other site 644966005033 Walker B; other site 644966005034 D-loop; other site 644966005035 H-loop/switch region; other site 644966005036 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966005037 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 644966005038 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 644966005039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005040 dimer interface [polypeptide binding]; other site 644966005041 conserved gate region; other site 644966005042 putative PBP binding loops; other site 644966005043 ABC-ATPase subunit interface; other site 644966005044 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 644966005045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005046 dimer interface [polypeptide binding]; other site 644966005047 conserved gate region; other site 644966005048 putative PBP binding loops; other site 644966005049 ABC-ATPase subunit interface; other site 644966005050 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 644966005051 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 644966005052 peptide binding site [polypeptide binding]; other site 644966005053 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 644966005054 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 644966005055 diaminopimelate decarboxylase; Region: lysA; TIGR01048 644966005056 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 644966005057 active site 644966005058 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 644966005059 substrate binding site [chemical binding]; other site 644966005060 catalytic residues [active] 644966005061 dimer interface [polypeptide binding]; other site 644966005062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966005063 putative substrate translocation pore; other site 644966005064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966005065 Staphylococcal nuclease homologues; Region: SNc; smart00318 644966005066 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 644966005067 Catalytic site; other site 644966005068 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 644966005069 Helix-turn-helix domains; Region: HTH; cl00088 644966005070 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; cl00986 644966005071 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 644966005072 short chain dehydrogenase; Provisional; Region: PRK07677 644966005073 NAD(P) binding site [chemical binding]; other site 644966005074 substrate binding site [chemical binding]; other site 644966005075 homotetramer interface [polypeptide binding]; other site 644966005076 active site 644966005077 homodimer interface [polypeptide binding]; other site 644966005078 Cysteine-rich domain; Region: CCG; pfam02754 644966005079 Cysteine-rich domain; Region: CCG; pfam02754 644966005080 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 644966005081 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 644966005082 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 644966005083 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; cl00674 644966005084 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 644966005085 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 644966005086 putative NAD(P) binding site [chemical binding]; other site 644966005087 catalytic Zn binding site [ion binding]; other site 644966005088 structural Zn binding site [ion binding]; other site 644966005089 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644966005090 DNA-binding site [nucleotide binding]; DNA binding site 644966005091 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 644966005092 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644966005093 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 644966005094 Walker A/P-loop; other site 644966005095 ATP binding site [chemical binding]; other site 644966005096 Q-loop/lid; other site 644966005097 ABC transporter signature motif; other site 644966005098 Walker B; other site 644966005099 D-loop; other site 644966005100 H-loop/switch region; other site 644966005101 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644966005102 dimerization interface [polypeptide binding]; other site 644966005103 putative DNA binding site [nucleotide binding]; other site 644966005104 putative Zn2+ binding site [ion binding]; other site 644966005105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 644966005106 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 644966005107 active site 644966005108 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 644966005109 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 644966005110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 644966005111 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 644966005112 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 644966005113 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 644966005114 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 644966005115 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 644966005116 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl14656 644966005117 homoserine kinase; Provisional; Region: PRK01212 644966005118 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 644966005119 threonine synthase; Reviewed; Region: PRK06721 644966005120 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 644966005121 homodimer interface [polypeptide binding]; other site 644966005122 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966005123 catalytic residue [active] 644966005124 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 644966005125 putative hydrophobic ligand binding site [chemical binding]; other site 644966005126 CLM binding site; other site 644966005127 L1 loop; other site 644966005128 DNA binding site [nucleotide binding] 644966005129 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 644966005130 dimerization interface [polypeptide binding]; other site 644966005131 putative DNA binding site [nucleotide binding]; other site 644966005132 putative Zn2+ binding site [ion binding]; other site 644966005133 acetyl-CoA synthetase; Provisional; Region: PRK00174 644966005134 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 644966005135 AMP-binding enzyme; Region: AMP-binding; cl15778 644966005136 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966005137 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 644966005138 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 644966005139 FAD binding domain; Region: FAD_binding_4; pfam01565 644966005140 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 644966005141 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 644966005142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 644966005143 NMT1-like family; Region: NMT1_2; cl15260 644966005144 enoyl-CoA hydratase; Provisional; Region: PRK06144 644966005145 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966005146 substrate binding site [chemical binding]; other site 644966005147 oxyanion hole (OAH) forming residues; other site 644966005148 trimer interface [polypeptide binding]; other site 644966005149 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762 644966005150 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 644966005151 CoA-transferase family III; Region: CoA_transf_3; pfam02515 644966005152 Transcriptional regulators [Transcription]; Region: GntR; COG1802 644966005153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644966005154 DNA-binding site [nucleotide binding]; DNA binding site 644966005155 FCD domain; Region: FCD; cl11656 644966005156 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 644966005157 CoA-transferase family III; Region: CoA_transf_3; pfam02515 644966005158 OsmC-like protein; Region: OsmC; cl00767 644966005159 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 644966005160 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 644966005161 putative hydrophobic ligand binding site [chemical binding]; other site 644966005162 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 644966005163 XdhC Rossmann domain; Region: XdhC_C; pfam13478 644966005164 O-methyltransferase; Region: Methyltransf_3; pfam01596 644966005165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966005166 S-adenosylmethionine binding site [chemical binding]; other site 644966005167 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966005168 NAD-dependent deacetylase; Provisional; Region: PRK00481 644966005169 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 644966005170 NAD+ binding site [chemical binding]; other site 644966005171 substrate binding site [chemical binding]; other site 644966005172 Zn binding site [ion binding]; other site 644966005173 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 644966005174 FAD binding domain; Region: FAD_binding_4; pfam01565 644966005175 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 644966005176 Prephenate dehydratase; Region: PDT; pfam00800 644966005177 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 644966005178 putative L-Phe binding site [chemical binding]; other site 644966005179 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 644966005180 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 644966005181 tetramer interface [polypeptide binding]; other site 644966005182 active site 644966005183 Mg2+/Mn2+ binding site [ion binding]; other site 644966005184 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 644966005185 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 644966005186 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 644966005187 ketol-acid reductoisomerase; Provisional; Region: PRK05479 644966005188 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005189 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 644966005190 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 644966005191 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 644966005192 active site 644966005193 catalytic residues [active] 644966005194 metal binding site [ion binding]; metal-binding site 644966005195 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 644966005196 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 644966005197 substrate binding site [chemical binding]; other site 644966005198 ligand binding site [chemical binding]; other site 644966005199 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 644966005200 substrate binding site [chemical binding]; other site 644966005201 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 644966005202 tartrate dehydrogenase; Provisional; Region: PRK08194 644966005203 Dehydratase family; Region: ILVD_EDD; cl00340 644966005204 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 644966005205 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644966005206 dimer interface [polypeptide binding]; other site 644966005207 PYR/PP interface [polypeptide binding]; other site 644966005208 TPP binding site [chemical binding]; other site 644966005209 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 644966005210 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 644966005211 TPP-binding site [chemical binding]; other site 644966005212 dimer interface [polypeptide binding]; other site 644966005213 Transcriptional regulator [Transcription]; Region: IclR; COG1414 644966005214 Helix-turn-helix domains; Region: HTH; cl00088 644966005215 Bacterial transcriptional regulator; Region: IclR; pfam01614 644966005216 acetaldehyde dehydrogenase; Validated; Region: PRK08300 644966005217 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005218 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 644966005219 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 644966005220 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 644966005221 active site 644966005222 catalytic residues [active] 644966005223 metal binding site [ion binding]; metal-binding site 644966005224 DmpG-like communication domain; Region: DmpG_comm; pfam07836 644966005225 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 644966005226 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 644966005227 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 644966005228 NAD binding site [chemical binding]; other site 644966005229 catalytic residues [active] 644966005230 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 644966005231 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 644966005232 active site 1 [active] 644966005233 dimer interface [polypeptide binding]; other site 644966005234 hexamer interface [polypeptide binding]; other site 644966005235 active site 2 [active] 644966005236 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966005237 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 644966005238 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 644966005239 Walker A/P-loop; other site 644966005240 ATP binding site [chemical binding]; other site 644966005241 Q-loop/lid; other site 644966005242 ABC transporter signature motif; other site 644966005243 Walker B; other site 644966005244 D-loop; other site 644966005245 H-loop/switch region; other site 644966005246 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 644966005247 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 644966005248 Walker A/P-loop; other site 644966005249 ATP binding site [chemical binding]; other site 644966005250 Q-loop/lid; other site 644966005251 ABC transporter signature motif; other site 644966005252 Walker B; other site 644966005253 D-loop; other site 644966005254 H-loop/switch region; other site 644966005255 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644966005256 TM-ABC transporter signature motif; other site 644966005257 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644966005258 TM-ABC transporter signature motif; other site 644966005259 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 644966005260 Type I periplasmic binding component of active transport systems that are predicted be involved in anaerobic biodegradation of alkylbenzenes such as toluene and ethylbenzene; Region: PBP1_alkylbenzenes_like; cd06360 644966005261 putative ligand binding site [chemical binding]; other site 644966005262 N-terminal, non-catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_N_like; cd09013 644966005263 tetramer interface [polypeptide binding]; other site 644966005264 catechol 2,3 dioxygenase; Region: catechol_2_3; TIGR03211 644966005265 C-terminal, catalytic, domain of BphC_JF8, (2,3-dihydroxybiphenyl 1,2-dioxygenase) from Bacillus sp. JF8 and similar proteins; Region: BphC-JF8_C_like; cd09014 644966005266 tetramer interface [polypeptide binding]; other site 644966005267 active site 644966005268 metal binding site [ion binding]; metal-binding site 644966005269 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 644966005270 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 644966005271 Flavin Reductases; Region: FlaRed; cl00801 644966005272 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 644966005273 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966005274 Walker A/P-loop; other site 644966005275 ATP binding site [chemical binding]; other site 644966005276 Q-loop/lid; other site 644966005277 ABC transporter signature motif; other site 644966005278 Walker B; other site 644966005279 D-loop; other site 644966005280 H-loop/switch region; other site 644966005281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966005282 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966005283 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966005284 Walker A/P-loop; other site 644966005285 ATP binding site [chemical binding]; other site 644966005286 Q-loop/lid; other site 644966005287 ABC transporter signature motif; other site 644966005288 Walker B; other site 644966005289 D-loop; other site 644966005290 H-loop/switch region; other site 644966005291 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966005292 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 644966005293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005294 dimer interface [polypeptide binding]; other site 644966005295 conserved gate region; other site 644966005296 putative PBP binding loops; other site 644966005297 ABC-ATPase subunit interface; other site 644966005298 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966005299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005300 dimer interface [polypeptide binding]; other site 644966005301 conserved gate region; other site 644966005302 putative PBP binding loops; other site 644966005303 ABC-ATPase subunit interface; other site 644966005304 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 644966005305 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966005306 hypothetical protein; Provisional; Region: PRK08201 644966005307 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 644966005308 metal binding site [ion binding]; metal-binding site 644966005309 putative dimer interface [polypeptide binding]; other site 644966005310 allantoate amidohydrolase; Reviewed; Region: PRK12890 644966005311 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 644966005312 active site 644966005313 metal binding site [ion binding]; metal-binding site 644966005314 dimer interface [polypeptide binding]; other site 644966005315 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 644966005316 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 644966005317 NAD(P) binding site [chemical binding]; other site 644966005318 catalytic residues [active] 644966005319 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 644966005320 Zinc-dependent alcohol dehydrogenases (ADH) and class III ADG (AKA formaldehyde dehydrogenase); Region: liver_ADH_like1; cd08281 644966005321 NAD binding site [chemical binding]; other site 644966005322 catalytic Zn binding site [ion binding]; other site 644966005323 substrate binding site [chemical binding]; other site 644966005324 structural Zn binding site [ion binding]; other site 644966005325 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966005326 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314 644966005327 AMP-binding enzyme; Region: AMP-binding; cl15778 644966005328 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 644966005329 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 644966005330 active site 644966005331 substrate binding pocket [chemical binding]; other site 644966005332 homodimer interaction site [polypeptide binding]; other site 644966005333 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966005334 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966005335 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 644966005336 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005337 NAD(P) binding site [chemical binding]; other site 644966005338 active site 644966005339 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 644966005340 active site 2 [active] 644966005341 active site 1 [active] 644966005342 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 644966005343 active site 644966005344 catalytic site [active] 644966005345 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 644966005346 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 644966005347 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 644966005348 putative ligand binding site [chemical binding]; other site 644966005349 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644966005350 TM-ABC transporter signature motif; other site 644966005351 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 644966005352 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 644966005353 Walker A/P-loop; other site 644966005354 ATP binding site [chemical binding]; other site 644966005355 Q-loop/lid; other site 644966005356 ABC transporter signature motif; other site 644966005357 Walker B; other site 644966005358 D-loop; other site 644966005359 H-loop/switch region; other site 644966005360 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 644966005361 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 644966005362 Walker A/P-loop; other site 644966005363 ATP binding site [chemical binding]; other site 644966005364 Q-loop/lid; other site 644966005365 ABC transporter signature motif; other site 644966005366 Walker B; other site 644966005367 D-loop; other site 644966005368 H-loop/switch region; other site 644966005369 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644966005370 TM-ABC transporter signature motif; other site 644966005371 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 644966005372 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 644966005373 tetramer interface [polypeptide binding]; other site 644966005374 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 644966005375 tetramer interface [polypeptide binding]; other site 644966005376 active site 644966005377 metal binding site [ion binding]; metal-binding site 644966005378 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 644966005379 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 644966005380 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 644966005381 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 644966005382 NAD binding site [chemical binding]; other site 644966005383 catalytic residues [active] 644966005384 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 644966005385 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 644966005386 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 644966005387 dihydrodipicolinate synthase; Region: dapA; TIGR00674 644966005388 dimer interface [polypeptide binding]; other site 644966005389 active site 644966005390 catalytic residue [active] 644966005391 Transcriptional regulators [Transcription]; Region: FadR; COG2186 644966005392 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 644966005393 DNA-binding site [nucleotide binding]; DNA binding site 644966005394 FCD domain; Region: FCD; cl11656 644966005395 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 644966005396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966005397 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 644966005398 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966005399 Family description; Region: UvrD_C_2; cl15862 644966005400 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 644966005401 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 644966005402 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 644966005403 amidase; Provisional; Region: PRK06529 644966005404 Amidase; Region: Amidase; cl11426 644966005405 Peptidase C26; Region: Peptidase_C26; pfam07722 644966005406 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 644966005407 catalytic triad [active] 644966005408 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 644966005409 Spore germination protein; Region: Spore_permease; cl15802 644966005410 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 644966005411 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 644966005412 Ligand Binding Site [chemical binding]; other site 644966005413 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 644966005414 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 644966005415 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 644966005416 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 644966005417 Protein of unknown function (DUF499); Region: DUF499; pfam04465 644966005418 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 644966005419 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 644966005420 intracellular protease, PfpI family; Region: PfpI; TIGR01382 644966005421 conserved cys residue [active] 644966005422 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 644966005423 putative substrate binding site [chemical binding]; other site 644966005424 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 644966005425 ATP binding site [chemical binding]; other site 644966005426 substrate binding site [chemical binding]; other site 644966005427 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 644966005428 hypothetical protein; Provisional; Region: PRK08185 644966005429 intersubunit interface [polypeptide binding]; other site 644966005430 active site 644966005431 zinc binding site [ion binding]; other site 644966005432 Na+ binding site [ion binding]; other site 644966005433 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644966005434 Helix-turn-helix domains; Region: HTH; cl00088 644966005435 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 644966005436 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 644966005437 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 644966005438 active site 644966005439 dimer interface [polypeptide binding]; other site 644966005440 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 644966005441 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 644966005442 dimer interface [polypeptide binding]; other site 644966005443 active site 644966005444 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 644966005445 dimer interface [polypeptide binding]; other site 644966005446 active site 644966005447 hypothetical protein; Provisional; Region: PRK02947 644966005448 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 644966005449 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 644966005450 putative active site [active] 644966005451 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 644966005452 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 644966005453 active site 644966005454 P-loop; other site 644966005455 phosphorylation site [posttranslational modification] 644966005456 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 644966005457 active site 644966005458 phosphorylation site [posttranslational modification] 644966005459 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 644966005460 AMP-binding enzyme; Region: AMP-binding; cl15778 644966005461 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 644966005462 active site 644966005463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644966005464 Helix-turn-helix domains; Region: HTH; cl00088 644966005465 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 644966005466 thiamine phosphate binding site [chemical binding]; other site 644966005467 active site 644966005468 pyrophosphate binding site [ion binding]; other site 644966005469 bifunctional sulfur carrier protein/thiazole synthase protein; Provisional; Region: PRK11840 644966005470 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 644966005471 thiS-thiF/thiG interaction site; other site 644966005472 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 644966005473 ThiS interaction site; other site 644966005474 putative active site [active] 644966005475 tetramer interface [polypeptide binding]; other site 644966005476 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 644966005477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005478 Uncharacterized conserved protein [Function unknown]; Region: COG3535 644966005479 Protein of unknown function (DUF917); Region: DUF917; pfam06032 644966005480 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 644966005481 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 644966005482 Uncharacterized conserved protein [Function unknown]; Region: COG3535 644966005483 Protein of unknown function (DUF917); Region: DUF917; pfam06032 644966005484 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 644966005485 Na binding site [ion binding]; other site 644966005486 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 644966005487 Helix-turn-helix domains; Region: HTH; cl00088 644966005488 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 644966005489 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 644966005490 NAD binding site [chemical binding]; other site 644966005491 substrate binding site [chemical binding]; other site 644966005492 catalytic Zn binding site [ion binding]; other site 644966005493 structural Zn binding site [ion binding]; other site 644966005494 Domain of unknown function DUF59; Region: DUF59; cl00941 644966005495 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 644966005496 transmembrane helices; other site 644966005497 acetolactate synthase catalytic subunit; Validated; Region: PRK08327 644966005498 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 644966005499 PYR/PP interface [polypeptide binding]; other site 644966005500 dimer interface [polypeptide binding]; other site 644966005501 TPP binding site [chemical binding]; other site 644966005502 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 644966005503 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 644966005504 TPP-binding site [chemical binding]; other site 644966005505 dimer interface [polypeptide binding]; other site 644966005506 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 644966005507 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644966005508 Zn2+ binding site [ion binding]; other site 644966005509 Mg2+ binding site [ion binding]; other site 644966005510 CheD chemotactic sensory transduction; Region: CheD; cl00810 644966005511 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 644966005512 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 644966005513 putative binding surface; other site 644966005514 active site 644966005515 P2 response regulator binding domain; Region: P2; pfam07194 644966005516 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 644966005517 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966005518 ATP binding site [chemical binding]; other site 644966005519 Mg2+ binding site [ion binding]; other site 644966005520 G-X-G motif; other site 644966005521 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 644966005522 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 644966005523 putative CheA interaction surface; other site 644966005524 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644966005525 dimerization interface [polypeptide binding]; other site 644966005526 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644966005527 dimer interface [polypeptide binding]; other site 644966005528 putative CheW interface [polypeptide binding]; other site 644966005529 Response regulator receiver domain; Region: Response_reg; pfam00072 644966005530 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966005531 active site 644966005532 phosphorylation site [posttranslational modification] 644966005533 intermolecular recognition site; other site 644966005534 dimerization interface [polypeptide binding]; other site 644966005535 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 644966005536 Chemotaxis phosphatase CheX; Region: CheX; cl15816 644966005537 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005538 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 644966005539 Cupin domain; Region: Cupin_2; cl09118 644966005540 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 644966005541 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 644966005542 active site 644966005543 substrate binding site [chemical binding]; other site 644966005544 metal binding site [ion binding]; metal-binding site 644966005545 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 644966005546 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 644966005547 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 644966005548 active site 644966005549 Substrate binding site; other site 644966005550 Mg++ binding site; other site 644966005551 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 644966005552 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 644966005553 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 644966005554 Walker A/P-loop; other site 644966005555 ATP binding site [chemical binding]; other site 644966005556 Q-loop/lid; other site 644966005557 ABC transporter signature motif; other site 644966005558 Walker B; other site 644966005559 D-loop; other site 644966005560 H-loop/switch region; other site 644966005561 TOBE domain; Region: TOBE_2; cl01440 644966005562 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 644966005563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005564 dimer interface [polypeptide binding]; other site 644966005565 conserved gate region; other site 644966005566 putative PBP binding loops; other site 644966005567 ABC-ATPase subunit interface; other site 644966005568 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 644966005569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005570 putative PBP binding loops; other site 644966005571 dimer interface [polypeptide binding]; other site 644966005572 ABC-ATPase subunit interface; other site 644966005573 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 644966005574 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 644966005575 Metal-binding active site; metal-binding site 644966005576 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644966005577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966005578 Protein of unknown function DUF262; Region: DUF262; cl14890 644966005579 Protein of unknown function DUF262; Region: DUF262; cl14890 644966005580 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644966005581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 644966005582 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644966005583 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 644966005584 Protein of unknown function DUF262; Region: DUF262; cl14890 644966005585 Divergent AAA domain; Region: AAA_4; pfam04326 644966005586 Transposase; Region: DEDD_Tnp_IS110; pfam01548 644966005587 Transposase [DNA replication, recombination, and repair]; Region: COG5421 644966005588 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966005589 putative substrate translocation pore; other site 644966005590 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966005591 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 644966005592 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 644966005593 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 644966005594 Spore germination protein; Region: Spore_permease; cl15802 644966005595 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 644966005596 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 644966005597 active site 644966005598 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 644966005599 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 644966005600 Walker A/P-loop; other site 644966005601 ATP binding site [chemical binding]; other site 644966005602 Q-loop/lid; other site 644966005603 ABC transporter signature motif; other site 644966005604 Walker B; other site 644966005605 D-loop; other site 644966005606 H-loop/switch region; other site 644966005607 MoxR-like ATPases [General function prediction only]; Region: COG0714 644966005608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966005609 Walker A motif; other site 644966005610 ATP binding site [chemical binding]; other site 644966005611 Walker B motif; other site 644966005612 arginine finger; other site 644966005613 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 644966005614 Fibronectin type III-like domain; Region: Fn3-like; cl15273 644966005615 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 644966005616 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 644966005617 metal ion-dependent adhesion site (MIDAS); other site 644966005618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966005619 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 644966005620 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966005621 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283 644966005622 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 644966005623 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 644966005624 Walker A/P-loop; other site 644966005625 ATP binding site [chemical binding]; other site 644966005626 Q-loop/lid; other site 644966005627 ABC transporter signature motif; other site 644966005628 Walker B; other site 644966005629 D-loop; other site 644966005630 H-loop/switch region; other site 644966005631 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 644966005632 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 644966005633 active site 644966005634 substrate-binding site [chemical binding]; other site 644966005635 metal-binding site [ion binding] 644966005636 ATP binding site [chemical binding]; other site 644966005637 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 644966005638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005640 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 644966005641 active site 644966005642 NTP binding site [chemical binding]; other site 644966005643 metal binding triad [ion binding]; metal-binding site 644966005644 Predicted GTPases [General function prediction only]; Region: COG1162 644966005645 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644966005646 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 644966005647 GTPase/Zn-binding domain interface [polypeptide binding]; other site 644966005648 GTP/Mg2+ binding site [chemical binding]; other site 644966005649 G4 box; other site 644966005650 G5 box; other site 644966005651 G1 box; other site 644966005652 Switch I region; other site 644966005653 G2 box; other site 644966005654 G3 box; other site 644966005655 Switch II region; other site 644966005656 Protein of unknown function (DUF541); Region: SIMPL; cl01077 644966005657 Uncharacterized conserved protein [Function unknown]; Region: COG3535 644966005658 Protein of unknown function (DUF917); Region: DUF917; pfam06032 644966005659 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 644966005660 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 644966005661 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 644966005662 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 644966005663 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 644966005664 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 644966005665 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 644966005666 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966005667 Walker A/P-loop; other site 644966005668 ATP binding site [chemical binding]; other site 644966005669 Q-loop/lid; other site 644966005670 ABC transporter signature motif; other site 644966005671 Walker B; other site 644966005672 D-loop; other site 644966005673 H-loop/switch region; other site 644966005674 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966005675 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 644966005676 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 644966005677 Walker A/P-loop; other site 644966005678 ATP binding site [chemical binding]; other site 644966005679 Q-loop/lid; other site 644966005680 ABC transporter signature motif; other site 644966005681 Walker B; other site 644966005682 D-loop; other site 644966005683 H-loop/switch region; other site 644966005684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 644966005685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005686 dimer interface [polypeptide binding]; other site 644966005687 conserved gate region; other site 644966005688 putative PBP binding loops; other site 644966005689 ABC-ATPase subunit interface; other site 644966005690 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 644966005691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005692 dimer interface [polypeptide binding]; other site 644966005693 conserved gate region; other site 644966005694 putative PBP binding loops; other site 644966005695 ABC-ATPase subunit interface; other site 644966005696 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 644966005697 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 644966005698 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 644966005699 catalytic triad [active] 644966005700 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 644966005701 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 644966005702 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966005703 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 644966005704 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966005705 DNA binding residues [nucleotide binding] 644966005706 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 644966005707 Helix-turn-helix domains; Region: HTH; cl00088 644966005708 ABC-2 type transporter; Region: ABC2_membrane; cl11417 644966005709 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 644966005710 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 644966005711 Walker A/P-loop; other site 644966005712 ATP binding site [chemical binding]; other site 644966005713 Q-loop/lid; other site 644966005714 ABC transporter signature motif; other site 644966005715 Walker B; other site 644966005716 D-loop; other site 644966005717 H-loop/switch region; other site 644966005718 Integrase core domain; Region: rve; cl01316 644966005719 Fatty acid desaturase; Region: FA_desaturase; pfam00487 644966005720 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 644966005721 putative di-iron ligands [ion binding]; other site 644966005722 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 644966005723 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 644966005724 FMN binding site [chemical binding]; other site 644966005725 substrate binding site [chemical binding]; other site 644966005726 putative catalytic residue [active] 644966005727 Uncharacterized conserved protein [Function unknown]; Region: COG1565 644966005728 Putative S-adenosyl-L-methionine-dependent methyltransferase; Region: Methyltransf_28; pfam02636 644966005729 Protein of unknown function DUF262; Region: DUF262; cl14890 644966005730 Protein of unknown function DUF262; Region: DUF262; cl14890 644966005731 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 644966005732 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 644966005733 catalytic residues [active] 644966005734 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3296; cl15800 644966005735 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 644966005736 active site 644966005737 Domain of unknown function DUF59; Region: DUF59; cl00941 644966005738 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 644966005739 TPP-binding site [chemical binding]; other site 644966005740 dimer interface [polypeptide binding]; other site 644966005741 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 644966005742 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 644966005743 PYR/PP interface [polypeptide binding]; other site 644966005744 dimer interface [polypeptide binding]; other site 644966005745 TPP binding site [chemical binding]; other site 644966005746 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 644966005747 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644966005748 intersubunit interface [polypeptide binding]; other site 644966005749 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 644966005750 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 644966005751 ABC-ATPase subunit interface; other site 644966005752 dimer interface [polypeptide binding]; other site 644966005753 putative PBP binding regions; other site 644966005754 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 644966005755 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 644966005756 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 644966005757 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 644966005758 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 644966005759 Membrane protein of unknown function (DUF340); Region: DUF340; cl01028 644966005760 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 644966005761 dimer interface [polypeptide binding]; other site 644966005762 substrate binding site [chemical binding]; other site 644966005763 ATP binding site [chemical binding]; other site 644966005764 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 644966005765 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 644966005766 substrate binding site [chemical binding]; other site 644966005767 multimerization interface [polypeptide binding]; other site 644966005768 ATP binding site [chemical binding]; other site 644966005769 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 644966005770 thiamine phosphate binding site [chemical binding]; other site 644966005771 active site 644966005772 pyrophosphate binding site [ion binding]; other site 644966005773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966005774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966005775 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 644966005776 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 644966005777 putative active site [active] 644966005778 putative metal binding site [ion binding]; other site 644966005779 threonine synthase; Validated; Region: PRK06260 644966005780 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 644966005781 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 644966005782 catalytic residue [active] 644966005783 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 644966005784 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966005785 Walker A/P-loop; other site 644966005786 ATP binding site [chemical binding]; other site 644966005787 Q-loop/lid; other site 644966005788 ABC transporter signature motif; other site 644966005789 Walker B; other site 644966005790 D-loop; other site 644966005791 H-loop/switch region; other site 644966005792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005793 dimer interface [polypeptide binding]; other site 644966005794 conserved gate region; other site 644966005795 putative PBP binding loops; other site 644966005796 ABC-ATPase subunit interface; other site 644966005797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966005798 dimer interface [polypeptide binding]; other site 644966005799 conserved gate region; other site 644966005800 putative PBP binding loops; other site 644966005801 ABC-ATPase subunit interface; other site 644966005802 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644966005803 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 644966005804 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 644966005805 homopentamer interface [polypeptide binding]; other site 644966005806 active site 644966005807 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 644966005808 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 644966005809 catalytic motif [active] 644966005810 Zn binding site [ion binding]; other site 644966005811 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 644966005812 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cl15243 644966005813 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 644966005814 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 644966005815 FtsX-like permease family; Region: FtsX; cl15850 644966005816 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 644966005817 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 644966005818 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 644966005819 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 644966005820 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 644966005821 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 644966005822 Walker A/P-loop; other site 644966005823 ATP binding site [chemical binding]; other site 644966005824 Q-loop/lid; other site 644966005825 ABC transporter signature motif; other site 644966005826 Walker B; other site 644966005827 D-loop; other site 644966005828 H-loop/switch region; other site 644966005829 PEP phosphonomutase and related enzymes [Carbohydrate transport and metabolism]; Region: PrpB; COG2513 644966005830 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 644966005831 tetramer interface [polypeptide binding]; other site 644966005832 active site 644966005833 Mg2+/Mn2+ binding site [ion binding]; other site 644966005834 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 644966005835 Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1; cd06118 644966005836 dimer interface [polypeptide binding]; other site 644966005837 Citrate synthase; Region: Citrate_synt; pfam00285 644966005838 active site 644966005839 coenzyme A binding site [chemical binding]; other site 644966005840 citrylCoA binding site [chemical binding]; other site 644966005841 oxalacetate/citrate binding site [chemical binding]; other site 644966005842 catalytic triad [active] 644966005843 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 644966005844 dimer interface [polypeptide binding]; other site 644966005845 putative radical transfer pathway; other site 644966005846 diiron center [ion binding]; other site 644966005847 tyrosyl radical; other site 644966005848 ribonucleoside-diphosphate reductase, alpha subunit; Region: NrdE_NrdA; TIGR02506 644966005849 Class I ribonucleotide reductase; Region: RNR_I; cd01679 644966005850 active site 644966005851 dimer interface [polypeptide binding]; other site 644966005852 catalytic residues [active] 644966005853 effector binding site; other site 644966005854 R2 peptide binding site; other site 644966005855 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 644966005856 motif II; other site 644966005857 acetoacetyl-CoA synthetase; Provisional; Region: PRK03584 644966005858 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 644966005859 AMP-binding enzyme; Region: AMP-binding; cl15778 644966005860 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 644966005861 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644966005862 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 644966005863 NAD(P) binding site [chemical binding]; other site 644966005864 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966005865 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 644966005866 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 644966005867 Walker A/P-loop; other site 644966005868 ATP binding site [chemical binding]; other site 644966005869 Q-loop/lid; other site 644966005870 ABC transporter signature motif; other site 644966005871 Walker B; other site 644966005872 D-loop; other site 644966005873 H-loop/switch region; other site 644966005874 TOBE domain; Region: TOBE_2; cl01440 644966005875 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 644966005876 nudix motif; other site 644966005877 Integral membrane protein TerC family; Region: TerC; cl10468 644966005878 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644966005879 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 644966005880 active site 644966005881 nucleotide binding site [chemical binding]; other site 644966005882 HIGH motif; other site 644966005883 KMSKS motif; other site 644966005884 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 644966005885 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 644966005886 ATP binding site [chemical binding]; other site 644966005887 substrate binding site [chemical binding]; other site 644966005888 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 644966005889 putative active site [active] 644966005890 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 644966005891 Helix-turn-helix domains; Region: HTH; cl00088 644966005892 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 644966005893 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 644966005894 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 644966005895 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 644966005896 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 644966005897 Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264 644966005898 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 644966005899 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 644966005900 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644966005901 active site 644966005902 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 644966005903 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 644966005904 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 644966005905 trimerization site [polypeptide binding]; other site 644966005906 active site 644966005907 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 644966005908 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 644966005909 active site residue [active] 644966005910 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 644966005911 active site residue [active] 644966005912 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 644966005913 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 644966005914 active site 644966005915 HIGH motif; other site 644966005916 dimer interface [polypeptide binding]; other site 644966005917 KMSKS motif; other site 644966005918 Uncharacterized membrane protein [Function unknown]; Region: COG3949 644966005919 Uncharacterized membrane protein [Function unknown]; Region: COG3949 644966005920 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644966005921 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 644966005922 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 644966005923 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 644966005924 DNA-binding site [nucleotide binding]; DNA binding site 644966005925 RNA-binding motif; other site 644966005926 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 644966005927 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 644966005928 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 644966005929 dimerization domain swap beta strand [polypeptide binding]; other site 644966005930 regulatory protein interface [polypeptide binding]; other site 644966005931 active site 644966005932 regulatory phosphorylation site [posttranslational modification]; other site 644966005933 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 644966005934 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 644966005935 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 644966005936 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 644966005937 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 644966005938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 644966005939 putative substrate translocation pore; other site 644966005940 Uncharacterized BCR, COG1649; Region: DUF187; cl15398 644966005941 GTP-binding protein YchF; Reviewed; Region: PRK09601 644966005942 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966005943 G1 box; other site 644966005944 GTP/Mg2+ binding site [chemical binding]; other site 644966005945 Switch I region; other site 644966005946 G3 box; other site 644966005947 Switch II region; other site 644966005948 G4 box; other site 644966005949 G5 box; other site 644966005950 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 644966005951 Uncharacterized conserved protein [Function unknown]; Region: COG1284 644966005952 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 644966005953 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 644966005954 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 644966005955 [2Fe-2S] cluster binding site [ion binding]; other site 644966005956 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 644966005957 FeS assembly protein SufB; Region: sufB; TIGR01980 644966005958 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 644966005959 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 644966005960 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 644966005961 active site 644966005962 dimer interface [polypeptide binding]; other site 644966005963 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 644966005964 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 644966005965 heterodimer interface [polypeptide binding]; other site 644966005966 active site 644966005967 FMN binding site [chemical binding]; other site 644966005968 homodimer interface [polypeptide binding]; other site 644966005969 substrate binding site [chemical binding]; other site 644966005970 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 644966005971 FAD binding pocket [chemical binding]; other site 644966005972 conserved FAD binding motif [chemical binding]; other site 644966005973 phosphate binding motif [ion binding]; other site 644966005974 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 644966005975 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644966005976 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 644966005977 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966005978 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 644966005979 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 644966005980 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644966005981 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 644966005982 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966005983 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 644966005984 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 644966005985 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 644966005986 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 644966005987 catalytic site [active] 644966005988 subunit interface [polypeptide binding]; other site 644966005989 dihydroorotase; Provisional; Region: PRK09237 644966005990 dihydroorotase, multifunctional complex type; Region: pyrC_multi; TIGR00857 644966005991 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 644966005992 active site 644966005993 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 644966005994 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 644966005995 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966005996 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 644966005997 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 644966005998 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 644966005999 Helix-turn-helix domains; Region: HTH; cl00088 644966006000 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 644966006001 L,D-transpeptidase catalytic domain; Region: YkuD; cl15405 644966006002 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 644966006003 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 644966006004 nucleophile elbow; other site 644966006005 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 644966006006 stage II sporulation protein P; Region: spore_II_P; TIGR02867 644966006007 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 644966006008 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 644966006009 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 644966006010 Arginase family; Region: Arginase; cl00306 644966006011 Rdx family; Region: Rdx; cl01407 644966006012 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 644966006013 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 644966006014 minor groove reading motif; other site 644966006015 helix-hairpin-helix signature motif; other site 644966006016 substrate binding pocket [chemical binding]; other site 644966006017 active site 644966006018 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 644966006019 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 644966006020 DNA binding and oxoG recognition site [nucleotide binding] 644966006021 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 644966006022 Catalytic site [active] 644966006023 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 644966006024 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 644966006025 OpgC protein; Region: OpgC_C; cl00792 644966006026 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 644966006027 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 644966006028 RNA/DNA hybrid binding site [nucleotide binding]; other site 644966006029 active site 644966006030 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966006031 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 644966006032 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 644966006033 Ligand Binding Site [chemical binding]; other site 644966006034 TIGR00269 family protein; Region: TIGR00269 644966006035 Protein of unknown function (DUF1451); Region: DUF1451; pfam07295 644966006036 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 644966006037 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 644966006038 endonuclease IV; Provisional; Region: PRK01060 644966006039 AP (apurinic/apyrimidinic) site pocket; other site 644966006040 DNA interaction; other site 644966006041 Metal-binding active site; metal-binding site 644966006042 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 644966006043 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 644966006044 Cytochrome C biogenesis protein; Region: CcmH; cl01179 644966006045 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 644966006046 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 644966006047 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 644966006048 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 644966006049 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 644966006050 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 644966006051 MoaE interaction surface [polypeptide binding]; other site 644966006052 MoeB interaction surface [polypeptide binding]; other site 644966006053 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 644966006054 MoaE homodimer interface [polypeptide binding]; other site 644966006055 MoaD interaction [polypeptide binding]; other site 644966006056 active site residues [active] 644966006057 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl15780 644966006058 hypothetical protein; Reviewed; Region: PRK09588 644966006059 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 644966006060 Archease protein family (MTH1598/TM1083); Region: Archease; cl00606 644966006061 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 644966006062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 644966006063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 644966006064 dimer interface [polypeptide binding]; other site 644966006065 conserved gate region; other site 644966006066 ABC-ATPase subunit interface; other site 644966006067 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 644966006068 ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond. Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256 644966006069 Walker A/P-loop; other site 644966006070 ATP binding site [chemical binding]; other site 644966006071 Q-loop/lid; other site 644966006072 ABC transporter signature motif; other site 644966006073 Walker B; other site 644966006074 D-loop; other site 644966006075 H-loop/switch region; other site 644966006076 phosphate/phosphite/phosphonate ABC transporters, periplasmic binding protein; Region: 3A0109s03R; TIGR01098 644966006077 NMT1-like family; Region: NMT1_2; cl15260 644966006078 CHASE3 domain; Region: CHASE3; cl05000 644966006079 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 644966006080 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644966006081 dimer interface [polypeptide binding]; other site 644966006082 putative CheW interface [polypeptide binding]; other site 644966006083 FAD binding domain; Region: FAD_binding_4; pfam01565 644966006084 D-lactate dehydrogenase [cytochrome]; Region: PLN02805 644966006085 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 644966006086 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 644966006087 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 644966006088 Chemotaxis phosphatase CheX; Region: CheX; cl15816 644966006089 Response regulator receiver domain; Region: Response_reg; pfam00072 644966006090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966006091 active site 644966006092 phosphorylation site [posttranslational modification] 644966006093 intermolecular recognition site; other site 644966006094 dimerization interface [polypeptide binding]; other site 644966006095 CHASE3 domain; Region: CHASE3; cl05000 644966006096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 644966006097 dimerization interface [polypeptide binding]; other site 644966006098 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 644966006099 dimer interface [polypeptide binding]; other site 644966006100 putative CheW interface [polypeptide binding]; other site 644966006101 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 644966006102 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 644966006103 putative binding surface; other site 644966006104 active site 644966006105 P2 response regulator binding domain; Region: P2; pfam07194 644966006106 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 644966006107 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966006108 ATP binding site [chemical binding]; other site 644966006109 Mg2+ binding site [ion binding]; other site 644966006110 G-X-G motif; other site 644966006111 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 644966006112 Response regulator receiver domain; Region: Response_reg; pfam00072 644966006113 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966006114 active site 644966006115 phosphorylation site [posttranslational modification] 644966006116 intermolecular recognition site; other site 644966006117 dimerization interface [polypeptide binding]; other site 644966006118 CheB methylesterase; Region: CheB_methylest; pfam01339 644966006119 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 644966006120 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966006121 C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356 644966006122 Domain of unknown function (DUF1850); Region: DUF1850; cl01950 644966006123 NMT1-like family; Region: NMT1_2; cl15260 644966006124 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 644966006125 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 644966006126 oligomer interface [polypeptide binding]; other site 644966006127 active site 644966006128 metal binding site [ion binding]; metal-binding site 644966006129 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; cl02748 644966006130 Methyltransferase domain; Region: Methyltransf_31; pfam13847 644966006131 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 644966006132 S-adenosylmethionine binding site [chemical binding]; other site 644966006133 Domain of unknown function (DUF4149); Region: DUF4149; pfam13664 644966006134 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 644966006135 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 644966006136 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 644966006137 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 644966006138 active site 644966006139 metal binding site [ion binding]; metal-binding site 644966006140 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 644966006141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966006142 active site 644966006143 phosphorylation site [posttranslational modification] 644966006144 intermolecular recognition site; other site 644966006145 dimerization interface [polypeptide binding]; other site 644966006146 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 644966006147 DNA binding residues [nucleotide binding] 644966006148 dimerization interface [polypeptide binding]; other site 644966006149 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 644966006150 Histidine kinase; Region: HisKA_3; pfam07730 644966006151 ABC-2 type transporter; Region: ABC2_membrane; cl11417 644966006152 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 644966006153 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 644966006154 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 644966006155 Walker A/P-loop; other site 644966006156 ATP binding site [chemical binding]; other site 644966006157 Q-loop/lid; other site 644966006158 ABC transporter signature motif; other site 644966006159 Walker B; other site 644966006160 D-loop; other site 644966006161 H-loop/switch region; other site 644966006162 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 644966006163 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 644966006164 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644966006165 inhibitor-cofactor binding pocket; inhibition site 644966006166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966006167 catalytic residue [active] 644966006168 Predicted dehydrogenase [General function prediction only]; Region: COG5322 644966006169 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966006170 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966006171 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 644966006172 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 644966006173 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644966006174 NAD(P) binding site [chemical binding]; other site 644966006175 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 644966006176 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 644966006177 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 644966006178 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 644966006179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966006180 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 644966006181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 644966006182 DNA binding residues [nucleotide binding] 644966006183 DNA primase, catalytic core; Region: dnaG; TIGR01391 644966006184 CHC2 zinc finger; Region: zf-CHC2; cl15369 644966006185 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 644966006186 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 644966006187 active site 644966006188 metal binding site [ion binding]; metal-binding site 644966006189 interdomain interaction site; other site 644966006190 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 644966006191 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 644966006192 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 644966006193 dimer interface [polypeptide binding]; other site 644966006194 active site 644966006195 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 644966006196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966006197 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 644966006198 3-hydroxy-acyl-CoA dehydrogenase; Validated; Region: PRK08268 644966006199 enoyl-CoA hydratase; Provisional; Region: PRK08140 644966006200 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 644966006201 substrate binding site [chemical binding]; other site 644966006202 oxyanion hole (OAH) forming residues; other site 644966006203 trimer interface [polypeptide binding]; other site 644966006204 Domain of unknown function DUF59; Region: DUF59; cl00941 644966006205 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 644966006206 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 644966006207 Phenylacetic acid degradation B; Region: PaaB; cl01371 644966006208 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 644966006209 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 644966006210 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 644966006211 Helix-turn-helix domains; Region: HTH; cl00088 644966006212 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 644966006213 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 644966006214 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 644966006215 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 644966006216 dimer interface [polypeptide binding]; other site 644966006217 phosphorylation site [posttranslational modification] 644966006218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966006219 ATP binding site [chemical binding]; other site 644966006220 Mg2+ binding site [ion binding]; other site 644966006221 G-X-G motif; other site 644966006222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966006223 active site 644966006224 phosphorylation site [posttranslational modification] 644966006225 intermolecular recognition site; other site 644966006226 dimerization interface [polypeptide binding]; other site 644966006227 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 644966006228 DNA binding site [nucleotide binding] 644966006229 ApbE family; Region: ApbE; cl00643 644966006230 ABC-2 type transporter; Region: ABC2_membrane; cl11417 644966006231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966006232 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 644966006233 Walker A/P-loop; other site 644966006234 ATP binding site [chemical binding]; other site 644966006235 Q-loop/lid; other site 644966006236 ABC transporter signature motif; other site 644966006237 Walker B; other site 644966006238 D-loop; other site 644966006239 H-loop/switch region; other site 644966006240 Protein of unknown function (DUF420); Region: DUF420; cl00989 644966006241 Response regulator receiver domain; Region: Response_reg; pfam00072 644966006242 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 644966006243 active site 644966006244 phosphorylation site [posttranslational modification] 644966006245 intermolecular recognition site; other site 644966006246 dimerization interface [polypeptide binding]; other site 644966006247 LytTr DNA-binding domain; Region: LytTR; cl04498 644966006248 GAF domain; Region: GAF; cl15785 644966006249 Histidine kinase; Region: His_kinase; pfam06580 644966006250 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 644966006251 ATP binding site [chemical binding]; other site 644966006252 Mg2+ binding site [ion binding]; other site 644966006253 G-X-G motif; other site 644966006254 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 644966006255 homodimer interface [polypeptide binding]; other site 644966006256 substrate-cofactor binding pocket; other site 644966006257 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966006258 catalytic residue [active] 644966006259 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 644966006260 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 644966006261 Stress responsive A/B Barrel Domain; Region: Dabb; cl15807 644966006262 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 644966006263 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966006264 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 644966006265 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 644966006266 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 644966006267 potassium/proton antiporter; Reviewed; Region: PRK05326 644966006268 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 644966006269 pyruvate phosphate dikinase; Provisional; Region: PRK09279 644966006270 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 644966006271 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 644966006272 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 644966006273 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 644966006274 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 644966006275 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 644966006276 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 644966006277 dimer interface [polypeptide binding]; other site 644966006278 motif 1; other site 644966006279 active site 644966006280 motif 2; other site 644966006281 motif 3; other site 644966006282 nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369 644966006283 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 644966006284 Recombination protein O N terminal; Region: RecO_N; cl15812 644966006285 DNA repair protein RecO; Region: reco; TIGR00613 644966006286 Recombination protein O C terminal; Region: RecO_C; pfam02565 644966006287 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 644966006288 MgtE intracellular N domain; Region: MgtE_N; cl15244 644966006289 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 644966006290 Divalent cation transporter; Region: MgtE; cl00786 644966006291 GTPase Era; Reviewed; Region: era; PRK00089 644966006292 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 644966006293 G1 box; other site 644966006294 GTP/Mg2+ binding site [chemical binding]; other site 644966006295 Switch I region; other site 644966006296 G2 box; other site 644966006297 Switch II region; other site 644966006298 G3 box; other site 644966006299 G4 box; other site 644966006300 G5 box; other site 644966006301 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 644966006302 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 644966006303 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 644966006304 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 644966006305 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 644966006306 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 644966006307 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 644966006308 Zn2+ binding site [ion binding]; other site 644966006309 Mg2+ binding site [ion binding]; other site 644966006310 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 644966006311 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 644966006312 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 644966006313 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 644966006314 YabP family; Region: YabP; cl06766 644966006315 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 644966006316 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 644966006317 dimer interface [polypeptide binding]; other site 644966006318 active site residues [active] 644966006319 GatB domain; Region: GatB_Yqey; cl11497 644966006320 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 644966006321 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 644966006322 nucleotide binding site/active site [active] 644966006323 HIT family signature motif; other site 644966006324 catalytic residue [active] 644966006325 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 644966006326 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 644966006327 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966006328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611 644966006329 RNA methyltransferase; Region: Methyltrans_RNA; pfam04452 644966006330 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 644966006331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966006332 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 644966006333 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 644966006334 HSP70 interaction site [polypeptide binding]; other site 644966006335 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 644966006336 Zn binding sites [ion binding]; other site 644966006337 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 644966006338 dimer interface [polypeptide binding]; other site 644966006339 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 644966006340 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 644966006341 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 644966006342 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 644966006343 dimer interface [polypeptide binding]; other site 644966006344 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 644966006345 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 644966006346 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 644966006347 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 644966006348 FeS/SAM binding site; other site 644966006349 HemN C-terminal domain; Region: HemN_C; pfam06969 644966006350 GTP-binding protein LepA; Provisional; Region: PRK05433 644966006351 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 644966006352 G1 box; other site 644966006353 putative GEF interaction site [polypeptide binding]; other site 644966006354 GTP/Mg2+ binding site [chemical binding]; other site 644966006355 Switch I region; other site 644966006356 G2 box; other site 644966006357 G3 box; other site 644966006358 Switch II region; other site 644966006359 G4 box; other site 644966006360 G5 box; other site 644966006361 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 644966006362 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 644966006363 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 644966006364 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 644966006365 Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973 644966006366 catalytic residues [active] 644966006367 stage II sporulation protein P; Region: spore_II_P; TIGR02867 644966006368 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 644966006369 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 644966006370 DNA polymerase III, delta subunit; Region: holA; TIGR01128 644966006371 Competence protein; Region: Competence; cl00471 644966006372 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 644966006373 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 644966006374 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 644966006375 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 644966006376 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 644966006377 HIGH motif; other site 644966006378 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644966006379 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 644966006380 active site 644966006381 KMSKS motif; other site 644966006382 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 644966006383 tRNA binding surface [nucleotide binding]; other site 644966006384 anticodon binding site; other site 644966006385 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 644966006386 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 644966006387 tRNA binding surface [nucleotide binding]; other site 644966006388 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 644966006389 Oligomerisation domain; Region: Oligomerisation; cl00519 644966006390 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 644966006391 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 644966006392 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 644966006393 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 644966006394 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 644966006395 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 644966006396 active site 644966006397 (T/H)XGH motif; other site 644966006398 GTPase CgtA; Reviewed; Region: obgE; PRK12297 644966006399 GTP1/OBG; Region: GTP1_OBG; pfam01018 644966006400 Obg GTPase; Region: Obg; cd01898 644966006401 G1 box; other site 644966006402 GTP/Mg2+ binding site [chemical binding]; other site 644966006403 Switch I region; other site 644966006404 G2 box; other site 644966006405 G3 box; other site 644966006406 Switch II region; other site 644966006407 G4 box; other site 644966006408 G5 box; other site 644966006409 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 644966006410 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 644966006411 Protein of unknown function (DUF464); Region: DUF464; cl01080 644966006412 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 644966006413 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 644966006414 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 644966006415 homodimer interface [polypeptide binding]; other site 644966006416 oligonucleotide binding site [chemical binding]; other site 644966006417 KH-II (K homology RNA-binding domain, type II). KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins (e.g. ribosomal protein S3), transcription factors (e.g. NusA_K), and post-transcriptional...; Region: KH-II; cl00098 644966006418 TRAM domain; Region: TRAM; cl01282 644966006419 Peptidase family M23; Region: Peptidase_M23; pfam01551 644966006420 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 644966006421 Septum formation topological specificity factor MinE; Region: MinE; cl00538 644966006422 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 644966006423 Switch I; other site 644966006424 Switch II; other site 644966006425 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 644966006426 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 644966006427 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 644966006428 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966006429 rod shape-determining protein MreC; Region: MreC; pfam04085 644966006430 rod shape-determining protein MreB; Provisional; Region: PRK13927 644966006431 Cell division protein FtsA; Region: FtsA; cl11496 644966006432 hypothetical protein; Reviewed; Region: PRK00024 644966006433 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 644966006434 MPN+ (JAMM) motif; other site 644966006435 Zinc-binding site [ion binding]; other site 644966006436 Maf-like protein; Provisional; Region: PRK14361 644966006437 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 644966006438 active site 644966006439 dimer interface [polypeptide binding]; other site 644966006440 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 644966006441 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 644966006442 active site 644966006443 HIGH motif; other site 644966006444 nucleotide binding site [chemical binding]; other site 644966006445 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 644966006446 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 644966006447 active site 644966006448 KMSKS motif; other site 644966006449 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 644966006450 tRNA binding surface [nucleotide binding]; other site 644966006451 anticodon binding site; other site 644966006452 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 644966006453 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 644966006454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966006455 Walker A motif; other site 644966006456 ATP binding site [chemical binding]; other site 644966006457 Walker B motif; other site 644966006458 arginine finger; other site 644966006459 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 644966006460 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 644966006461 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 644966006462 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966006463 Walker A motif; other site 644966006464 ATP binding site [chemical binding]; other site 644966006465 Walker B motif; other site 644966006466 arginine finger; other site 644966006467 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 644966006468 Clp protease; Region: CLP_protease; pfam00574 644966006469 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 644966006470 oligomer interface [polypeptide binding]; other site 644966006471 active site residues [active] 644966006472 trigger factor; Provisional; Region: tig; PRK01490 644966006473 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 644966006474 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 644966006475 spermidine synthase; Provisional; Region: PRK00811 644966006476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966006477 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 644966006478 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 644966006479 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 644966006480 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 644966006481 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 644966006482 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 644966006483 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 644966006484 active site 644966006485 dimerization interface [polypeptide binding]; other site 644966006486 MutL protein; Region: MutL; pfam13941 644966006487 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 644966006488 active site 644966006489 DNA polymerase IV; Validated; Region: PRK02406 644966006490 DNA binding site [nucleotide binding] 644966006491 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 644966006492 SmpB-tmRNA interface; other site 644966006493 ribonuclease R; Region: RNase_R; TIGR02063 644966006494 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644966006495 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 644966006496 RNB domain; Region: RNB; pfam00773 644966006497 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 644966006498 RNA binding site [nucleotide binding]; other site 644966006499 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 644966006500 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 644966006501 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 644966006502 Preprotein translocase SecG subunit; Region: SecG; cl09123 644966006503 enolase; Provisional; Region: eno; PRK00077 644966006504 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 644966006505 dimer interface [polypeptide binding]; other site 644966006506 metal binding site [ion binding]; metal-binding site 644966006507 substrate binding pocket [chemical binding]; other site 644966006508 Sulfatase; Region: Sulfatase; cl10460 644966006509 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 644966006510 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 644966006511 dimer interface [polypeptide binding]; other site 644966006512 substrate binding site [chemical binding]; other site 644966006513 catalytic triad [active] 644966006514 Phosphoglycerate kinase; Region: PGK; pfam00162 644966006515 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 644966006516 substrate binding site [chemical binding]; other site 644966006517 hinge regions; other site 644966006518 ADP binding site [chemical binding]; other site 644966006519 catalytic site [active] 644966006520 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 644966006521 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 644966006522 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 644966006523 Asp23 family; Region: Asp23; cl00574 644966006524 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 644966006525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644966006526 inhibitor-cofactor binding pocket; inhibition site 644966006527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966006528 catalytic residue [active] 644966006529 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 644966006530 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 644966006531 non-specific DNA binding site [nucleotide binding]; other site 644966006532 salt bridge; other site 644966006533 sequence-specific DNA binding site [nucleotide binding]; other site 644966006534 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 644966006535 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 644966006536 Glutamate binding site [chemical binding]; other site 644966006537 homodimer interface [polypeptide binding]; other site 644966006538 NAD binding site [chemical binding]; other site 644966006539 catalytic residues [active] 644966006540 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 644966006541 metal binding site 2 [ion binding]; metal-binding site 644966006542 putative DNA binding helix; other site 644966006543 metal binding site 1 [ion binding]; metal-binding site 644966006544 dimer interface [polypeptide binding]; other site 644966006545 structural Zn2+ binding site [ion binding]; other site 644966006546 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 644966006547 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644966006548 protein binding site [polypeptide binding]; other site 644966006549 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 644966006550 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 644966006551 DTAP/Switch II; other site 644966006552 Switch I; other site 644966006553 Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374 644966006554 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 644966006555 DTAP/Switch II; other site 644966006556 Switch I; other site 644966006557 Carbon starvation protein CstA; Region: CstA; pfam02554 644966006558 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 644966006559 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 644966006560 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 644966006561 ATP-grasp domain; Region: ATP-grasp_4; cl03087 644966006562 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 644966006563 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 644966006564 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 644966006565 23S rRNA interface [nucleotide binding]; other site 644966006566 L3 interface [polypeptide binding]; other site 644966006567 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 644966006568 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 644966006569 dimerization interface 3.5A [polypeptide binding]; other site 644966006570 active site 644966006571 Cobalt transport protein; Region: CbiQ; cl00463 644966006572 Cobalt transport protein; Region: CbiQ; cl00463 644966006573 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 644966006574 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 644966006575 Walker A/P-loop; other site 644966006576 ATP binding site [chemical binding]; other site 644966006577 Q-loop/lid; other site 644966006578 ABC transporter signature motif; other site 644966006579 Walker B; other site 644966006580 D-loop; other site 644966006581 H-loop/switch region; other site 644966006582 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 644966006583 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 644966006584 Walker A/P-loop; other site 644966006585 ATP binding site [chemical binding]; other site 644966006586 Q-loop/lid; other site 644966006587 ABC transporter signature motif; other site 644966006588 Walker B; other site 644966006589 D-loop; other site 644966006590 H-loop/switch region; other site 644966006591 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 644966006592 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 644966006593 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 644966006594 alphaNTD homodimer interface [polypeptide binding]; other site 644966006595 alphaNTD - beta interaction site [polypeptide binding]; other site 644966006596 alphaNTD - beta' interaction site [polypeptide binding]; other site 644966006597 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 644966006598 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 644966006599 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 644966006600 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 644966006601 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 644966006602 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 644966006603 rRNA binding site [nucleotide binding]; other site 644966006604 predicted 30S ribosome binding site; other site 644966006605 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 644966006606 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 644966006607 active site 644966006608 adenylate kinase; Reviewed; Region: adk; PRK00279 644966006609 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 644966006610 AMP-binding site [chemical binding]; other site 644966006611 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 644966006612 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 644966006613 SecY translocase; Region: SecY; pfam00344 644966006614 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 644966006615 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 644966006616 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 644966006617 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 644966006618 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 644966006619 5S rRNA interface [nucleotide binding]; other site 644966006620 L27 interface [polypeptide binding]; other site 644966006621 23S rRNA interface [nucleotide binding]; other site 644966006622 L5 interface [polypeptide binding]; other site 644966006623 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 644966006624 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644966006625 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 644966006626 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 644966006627 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 644966006628 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 644966006629 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 644966006630 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 644966006631 KOW motif; Region: KOW; cl00354 644966006632 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 644966006633 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 644966006634 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 644966006635 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 644966006636 23S rRNA interface [nucleotide binding]; other site 644966006637 putative translocon interaction site; other site 644966006638 signal recognition particle (SRP54) interaction site; other site 644966006639 L23 interface [polypeptide binding]; other site 644966006640 trigger factor interaction site; other site 644966006641 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 644966006642 23S rRNA interface [nucleotide binding]; other site 644966006643 5S rRNA interface [nucleotide binding]; other site 644966006644 putative antibiotic binding site [chemical binding]; other site 644966006645 L25 interface [polypeptide binding]; other site 644966006646 L27 interface [polypeptide binding]; other site 644966006647 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 644966006648 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 644966006649 G-X-X-G motif; other site 644966006650 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 644966006651 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 644966006652 putative translocon binding site; other site 644966006653 protein-rRNA interface [nucleotide binding]; other site 644966006654 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 644966006655 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 644966006656 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 644966006657 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 644966006658 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 644966006659 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 644966006660 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 644966006661 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 644966006662 elongation factor G; Reviewed; Region: PRK00007 644966006663 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 644966006664 G1 box; other site 644966006665 putative GEF interaction site [polypeptide binding]; other site 644966006666 GTP/Mg2+ binding site [chemical binding]; other site 644966006667 Switch I region; other site 644966006668 G2 box; other site 644966006669 G3 box; other site 644966006670 Switch II region; other site 644966006671 G4 box; other site 644966006672 G5 box; other site 644966006673 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 644966006674 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 644966006675 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 644966006676 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 644966006677 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 644966006678 S17 interaction site [polypeptide binding]; other site 644966006679 S8 interaction site; other site 644966006680 16S rRNA interaction site [nucleotide binding]; other site 644966006681 streptomycin interaction site [chemical binding]; other site 644966006682 23S rRNA interaction site [nucleotide binding]; other site 644966006683 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 644966006684 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 644966006685 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 644966006686 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 644966006687 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 644966006688 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 644966006689 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 644966006690 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 644966006691 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 644966006692 G-loop; other site 644966006693 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 644966006694 DNA binding site [nucleotide binding] 644966006695 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 644966006696 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 644966006697 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 644966006698 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 644966006699 RPB1 interaction site [polypeptide binding]; other site 644966006700 RPB10 interaction site [polypeptide binding]; other site 644966006701 RPB11 interaction site [polypeptide binding]; other site 644966006702 RPB3 interaction site [polypeptide binding]; other site 644966006703 RPB12 interaction site [polypeptide binding]; other site 644966006704 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 644966006705 peripheral dimer interface [polypeptide binding]; other site 644966006706 core dimer interface [polypeptide binding]; other site 644966006707 L10 interface [polypeptide binding]; other site 644966006708 L11 interface [polypeptide binding]; other site 644966006709 putative EF-Tu interaction site [polypeptide binding]; other site 644966006710 putative EF-G interaction site [polypeptide binding]; other site 644966006711 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 644966006712 23S rRNA interface [nucleotide binding]; other site 644966006713 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 644966006714 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 644966006715 mRNA/rRNA interface [nucleotide binding]; other site 644966006716 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 644966006717 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 644966006718 23S rRNA interface [nucleotide binding]; other site 644966006719 L7/L12 interface [polypeptide binding]; other site 644966006720 putative thiostrepton binding site; other site 644966006721 L25 interface [polypeptide binding]; other site 644966006722 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 644966006723 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 644966006724 putative homodimer interface [polypeptide binding]; other site 644966006725 KOW motif; Region: KOW; cl00354 644966006726 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 644966006727 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 644966006728 elongation factor Tu; Reviewed; Region: PRK00049 644966006729 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 644966006730 G1 box; other site 644966006731 GEF interaction site [polypeptide binding]; other site 644966006732 GTP/Mg2+ binding site [chemical binding]; other site 644966006733 Switch I region; other site 644966006734 G2 box; other site 644966006735 G3 box; other site 644966006736 Switch II region; other site 644966006737 G4 box; other site 644966006738 G5 box; other site 644966006739 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 644966006740 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 644966006741 Antibiotic Binding Site [chemical binding]; other site 644966006742 RNA polymerase factor sigma-70; Validated; Region: PRK08295 644966006743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 644966006744 Helix-turn-helix domains; Region: HTH; cl00088 644966006745 DNA binding residues [nucleotide binding] 644966006746 dimerization interface [polypeptide binding]; other site 644966006747 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 644966006748 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 644966006749 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644966006750 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 644966006751 active site 644966006752 HIGH motif; other site 644966006753 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 644966006754 KMSKS motif; other site 644966006755 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 644966006756 serine O-acetyltransferase; Region: cysE; TIGR01172 644966006757 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 644966006758 trimer interface [polypeptide binding]; other site 644966006759 active site 644966006760 substrate binding site [chemical binding]; other site 644966006761 CoA binding site [chemical binding]; other site 644966006762 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 644966006763 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 644966006764 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 644966006765 substrate binding site; other site 644966006766 dimer interface; other site 644966006767 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 644966006768 homotrimer interaction site [polypeptide binding]; other site 644966006769 zinc binding site [ion binding]; other site 644966006770 CDP-binding sites; other site 644966006771 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 644966006772 putative active site [active] 644966006773 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 644966006774 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 644966006775 metal binding site [ion binding]; metal-binding site 644966006776 ATP-sulfurylase; Region: ATPS; cd00517 644966006777 ATP sulphurylase; Region: sopT; TIGR00339 644966006778 active site 644966006779 HXXH motif; other site 644966006780 flexible loop; other site 644966006781 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 644966006782 Active Sites [active] 644966006783 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 644966006784 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 644966006785 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 644966006786 DNA repair protein RadA; Provisional; Region: PRK11823 644966006787 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 644966006788 Walker A motif/ATP binding site; other site 644966006789 ATP binding site [chemical binding]; other site 644966006790 Walker B motif; other site 644966006791 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 644966006792 Clp protease ATP binding subunit; Region: clpC; CHL00095 644966006793 Clp amino terminal domain; Region: Clp_N; pfam02861 644966006794 Clp amino terminal domain; Region: Clp_N; pfam02861 644966006795 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966006796 Walker A motif; other site 644966006797 ATP binding site [chemical binding]; other site 644966006798 Walker B motif; other site 644966006799 arginine finger; other site 644966006800 UvrB/uvrC motif; Region: UVR; pfam02151 644966006801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 644966006802 Walker A motif; other site 644966006803 ATP binding site [chemical binding]; other site 644966006804 Walker B motif; other site 644966006805 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 644966006806 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 644966006807 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 644966006808 ADP binding site [chemical binding]; other site 644966006809 phosphagen binding site; other site 644966006810 substrate specificity loop; other site 644966006811 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 644966006812 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 644966006813 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 644966006814 active site 644966006815 putative substrate binding pocket [chemical binding]; other site 644966006816 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 644966006817 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 644966006818 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 644966006819 Helix-turn-helix domains; Region: HTH; cl00088 644966006820 AsnC family; Region: AsnC_trans_reg; pfam01037 644966006821 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 644966006822 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 644966006823 inhibitor-cofactor binding pocket; inhibition site 644966006824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 644966006825 catalytic residue [active] 644966006826 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 644966006827 ligand binding site [chemical binding]; other site 644966006828 flexible hinge region; other site 644966006829 Helix-turn-helix domains; Region: HTH; cl00088 644966006830 Yip1 domain; Region: Yip1; cl12048 644966006831 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 644966006832 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 644966006833 tandem repeat interface [polypeptide binding]; other site 644966006834 oligomer interface [polypeptide binding]; other site 644966006835 active site residues [active] 644966006836 CTP synthetase; Validated; Region: pyrG; PRK05380 644966006837 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 644966006838 Catalytic site [active] 644966006839 active site 644966006840 UTP binding site [chemical binding]; other site 644966006841 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 644966006842 active site 644966006843 putative oxyanion hole; other site 644966006844 catalytic triad [active] 644966006845 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 644966006846 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 644966006847 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 644966006848 active site 644966006849 HIGH motif; other site 644966006850 KMSK motif region; other site 644966006851 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 644966006852 tRNA binding surface [nucleotide binding]; other site 644966006853 anticodon binding site; other site 644966006854 Arginase family; Region: Arginase; cl00306 644966006855 spermidine synthase; Provisional; Region: PRK00811 644966006856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966006857 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 644966006858 Transglycosylase; Region: Transgly; cl07896 644966006859 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 644966006860 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 644966006861 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590 644966006862 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 644966006863 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 644966006864 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 644966006865 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 644966006866 protein binding site [polypeptide binding]; other site 644966006867 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 644966006868 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 644966006869 G5 domain; Region: G5; pfam07501 644966006870 Peptidase family M23; Region: Peptidase_M23; pfam01551 644966006871 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 644966006872 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 644966006873 GDP-binding site [chemical binding]; other site 644966006874 ACT binding site; other site 644966006875 IMP binding site; other site 644966006876 replicative DNA helicase; Region: DnaB; TIGR00665 644966006877 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 644966006878 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 644966006879 Walker A motif; other site 644966006880 ATP binding site [chemical binding]; other site 644966006881 Walker B motif; other site 644966006882 DNA binding loops [nucleotide binding] 644966006883 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 644966006884 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 644966006885 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 644966006886 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 644966006887 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 644966006888 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 644966006889 dimer interface [polypeptide binding]; other site 644966006890 ssDNA binding site [nucleotide binding]; other site 644966006891 tetramer (dimer of dimers) interface [polypeptide binding]; other site 644966006892 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 644966006893 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 644966006894 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 644966006895 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 644966006896 Walker A/P-loop; other site 644966006897 ATP binding site [chemical binding]; other site 644966006898 Q-loop/lid; other site 644966006899 ABC transporter signature motif; other site 644966006900 Walker B; other site 644966006901 D-loop; other site 644966006902 H-loop/switch region; other site 644966006903 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 644966006904 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 644966006905 Walker A/P-loop; other site 644966006906 ATP binding site [chemical binding]; other site 644966006907 Q-loop/lid; other site 644966006908 ABC transporter signature motif; other site 644966006909 Walker B; other site 644966006910 D-loop; other site 644966006911 H-loop/switch region; other site 644966006912 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 644966006913 TM-ABC transporter signature motif; other site 644966006914 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 644966006915 TM-ABC transporter signature motif; other site 644966006916 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 644966006917 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 644966006918 putative ligand binding site [chemical binding]; other site 644966006919 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 644966006920 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 644966006921 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 644966006922 Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440 644966006923 ParB-like partition proteins; Region: parB_part; TIGR00180 644966006924 ParB-like nuclease domain; Region: ParBc; cl02129 644966006925 KorB domain; Region: KorB; pfam08535 644966006926 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 644966006927 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644966006928 P-loop; other site 644966006929 Magnesium ion binding site [ion binding]; other site 644966006930 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 644966006931 Magnesium ion binding site [ion binding]; other site 644966006932 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 644966006933 ParB-like nuclease domain; Region: ParBc; cl02129 644966006934 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl16911 644966006935 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 644966006936 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 644966006937 G-X-X-G motif; other site 644966006938 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 644966006939 RxxxH motif; other site 644966006940 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 644966006941 Haemolytic domain; Region: Haemolytic; cl00506 644966006942 Ribonuclease P; Region: Ribonuclease_P; cl00457 644966006943 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 644966006944 Integrase core domain; Region: rve; cl01316