-- dump date   	20120504_163843
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
635013000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
635013000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
635013000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000004	Walker A motif; other site
635013000005	ATP binding site [chemical binding]; other site
635013000006	Walker B motif; other site
635013000007	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013000008	arginine finger; other site
635013000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
635013000010	DnaA box-binding interface [nucleotide binding]; other site
635013000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
635013000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
635013000013	putative DNA binding surface [nucleotide binding]; other site
635013000014	dimer interface [polypeptide binding]; other site
635013000015	beta-clamp/clamp loader binding surface; other site
635013000016	beta-clamp/translesion DNA polymerase binding surface; other site
635013000017	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
635013000018	recombination protein F; Reviewed; Region: recF; PRK00064
635013000019	RecF is a recombinational DNA repair ATPase that maintains replication in the presence of DNA damage.  When replication is prematurely disrupted by DNA damage, several recF pathway gene products play critical roles processing the arrested replication...; Region: ABC_RecF; cd03242
635013000020	Walker A/P-loop; other site
635013000021	ATP binding site [chemical binding]; other site
635013000022	Q-loop/lid; other site
635013000023	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013000024	ABC transporter signature motif; other site
635013000025	Walker B; other site
635013000026	D-loop; other site
635013000027	H-loop/switch region; other site
635013000028	Domain of unknown function (DUF370); Region: DUF370; cl00898
635013000029	Transposase domain (DUF772); Region: DUF772; cl15789
635013000030	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013000031	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
635013000032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013000033	Mg2+ binding site [ion binding]; other site
635013000034	G-X-G motif; other site
635013000035	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
635013000036	anchoring element; other site
635013000037	dimer interface [polypeptide binding]; other site
635013000038	ATP binding site [chemical binding]; other site
635013000039	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
635013000040	active site
635013000041	putative metal-binding site [ion binding]; other site
635013000042	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
635013000043	DNA gyrase subunit A; Validated; Region: PRK05560
635013000044	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
635013000045	CAP-like domain; other site
635013000046	active site
635013000047	primary dimer interface [polypeptide binding]; other site
635013000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
635013000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
635013000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
635013000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
635013000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
635013000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
635013000054	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
635013000055	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
635013000056	active site
635013000057	multimer interface [polypeptide binding]; other site
635013000058	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
635013000059	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
635013000060	predicted active site [active]
635013000061	catalytic triad [active]
635013000062	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
635013000063	homodimer interface [polypeptide binding]; other site
635013000064	substrate-cofactor binding pocket; other site
635013000065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013000066	catalytic residue [active]
635013000067	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
635013000068	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013000069	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
635013000070	putative L-serine binding site [chemical binding]; other site
635013000071	seryl-tRNA synthetase; Provisional; Region: PRK05431
635013000072	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
635013000073	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
635013000074	dimer interface [polypeptide binding]; other site
635013000075	active site
635013000076	motif 1; other site
635013000077	motif 2; other site
635013000078	motif 3; other site
635013000079	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
635013000080	nucleoside/Zn binding site; other site
635013000081	dimer interface [polypeptide binding]; other site
635013000082	catalytic motif [active]
635013000083	biotin synthase; Region: bioB; TIGR00433
635013000084	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013000085	FeS/SAM binding site; other site
635013000086	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
635013000087	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
635013000088	DNA-binding site [nucleotide binding]; DNA binding site
635013000089	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
635013000090	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
635013000091	Walker A/P-loop; other site
635013000092	ATP binding site [chemical binding]; other site
635013000093	Q-loop/lid; other site
635013000094	ABC transporter signature motif; other site
635013000095	Walker B; other site
635013000096	D-loop; other site
635013000097	H-loop/switch region; other site
635013000098	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
635013000099	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
635013000100	protein binding site [polypeptide binding]; other site
635013000101	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
635013000102	Catalytic dyad [active]
635013000103	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
635013000104	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cd00768
635013000105	motif 1; other site
635013000106	dimer interface [polypeptide binding]; other site
635013000107	active site
635013000108	motif 2; other site
635013000109	motif 3; other site
635013000110	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
635013000111	active site
635013000112	ATP binding site [chemical binding]; other site
635013000113	substrate binding site [chemical binding]; other site
635013000114	dimer interface [polypeptide binding]; other site
635013000115	pyrrolysine biosynthesis radical SAM protein; Region: pyrrolys_PylB; TIGR03910
635013000116	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013000117	FeS/SAM binding site; other site
635013000118	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013000119	pyrrolysine biosynthesis protein PylC; Region: pyrrolys_PylC; TIGR03909
635013000120	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013000121	pyrrolysine biosynthesis protein PylD; Region: pyrrolys_PylD; TIGR03911
635013000122	pyrrolysyl-tRNA synthetase, N-terminal region; Region: PylS_Nterm; TIGR03912
635013000123	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013000124	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013000125	B12 binding site [chemical binding]; other site
635013000126	cobalt ligand [ion binding]; other site
635013000127	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
635013000128	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013000129	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
635013000130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000131	Walker A motif; other site
635013000132	ATP binding site [chemical binding]; other site
635013000133	Walker B motif; other site
635013000134	arginine finger; other site
635013000135	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013000136	active site
635013000137	substrate binding site [chemical binding]; other site
635013000138	ATP binding site [chemical binding]; other site
635013000139	Sodium:solute symporter family; Region: SSF; cl00456
635013000140	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
635013000141	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
635013000142	putative hexamer interface [polypeptide binding]; other site
635013000143	putative hexagonal pore; other site
635013000144	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
635013000145	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
635013000146	G1 box; other site
635013000147	GTP/Mg2+ binding site [chemical binding]; other site
635013000148	Switch I region; other site
635013000149	G3 box; other site
635013000150	Switch II region; other site
635013000151	G4 box; other site
635013000152	G5 box; other site
635013000153	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
635013000154	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
635013000155	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762
635013000156	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
635013000157	ethanolamine utilization protein EutL; Provisional; Region: PRK15405
635013000158	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049
635013000159	putative hexamer interface [polypeptide binding]; other site
635013000160	putative hexagonal pore; other site
635013000161	ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050
635013000162	putative hexamer interface [polypeptide binding]; other site
635013000163	putative hexagonal pore; other site
635013000164	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
635013000165	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
635013000166	Cell division protein FtsA; Region: FtsA; cl11496
635013000167	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
635013000168	Hexamer interface [polypeptide binding]; other site
635013000169	Hexagonal pore residue; other site
635013000170	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
635013000171	Hexamer/Pentamer interface [polypeptide binding]; other site
635013000172	central pore; other site
635013000173	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
635013000174	SLBB domain; Region: SLBB; pfam10531
635013000175	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
635013000176	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
635013000177	ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526
635013000178	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
635013000179	putative hexamer interface [polypeptide binding]; other site
635013000180	putative hexagonal pore; other site
635013000181	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
635013000182	putative hexamer interface [polypeptide binding]; other site
635013000183	putative hexagonal pore; other site
635013000184	Cupin domain; Region: Cupin_2; cl09118
635013000185	Ethanolamine utilisation protein EutQ; Region: EutQ; pfam06249
635013000186	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
635013000187	Hexamer interface [polypeptide binding]; other site
635013000188	Putative hexagonal pore residue; other site
635013000189	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
635013000190	Hexamer interface [polypeptide binding]; other site
635013000191	Hexagonal pore residue; other site
635013000192	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
635013000193	putative catalytic cysteine [active]
635013000194	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
635013000195	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013000196	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013000197	Acetokinase family; Region: Acetate_kinase; cl01029
635013000198	propionate/acetate kinase; Provisional; Region: PRK12379
635013000199	aromatic acid decarboxylase; Validated; Region: PRK05920
635013000200	Flavoprotein; Region: Flavoprotein; cl08021
635013000201	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
635013000202	Sensory domain found in PocR; Region: PocR; pfam10114
635013000203	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
635013000204	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
635013000205	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
635013000206	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013000207	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013000208	B12 binding site [chemical binding]; other site
635013000209	cobalt ligand [ion binding]; other site
635013000210	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
635013000211	MoxR-like ATPases [General function prediction only]; Region: COG0714
635013000212	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000213	Walker A motif; other site
635013000214	ATP binding site [chemical binding]; other site
635013000215	Walker B motif; other site
635013000216	arginine finger; other site
635013000217	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
635013000218	metal ion-dependent adhesion site (MIDAS); other site
635013000219	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013000220	Phosphotransferase enzyme family; Region: APH; pfam01636
635013000221	active site
635013000222	substrate binding site [chemical binding]; other site
635013000223	ATP binding site [chemical binding]; other site
635013000224	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
635013000225	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013000226	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013000227	B12 binding site [chemical binding]; other site
635013000228	cobalt ligand [ion binding]; other site
635013000229	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
635013000230	substrate binding pocket [chemical binding]; other site
635013000231	dimer interface [polypeptide binding]; other site
635013000232	inhibitor binding site; inhibition site
635013000233	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
635013000234	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
635013000235	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013000236	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
635013000237	catalytic loop [active]
635013000238	iron binding site [ion binding]; other site
635013000239	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
635013000240	catalytic site [active]
635013000241	metal binding site [ion binding]; metal-binding site
635013000242	Domain of unknown function DUF77; Region: DUF77; cl00307
635013000243	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
635013000244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013000245	dimer interface [polypeptide binding]; other site
635013000246	conserved gate region; other site
635013000247	putative PBP binding loops; other site
635013000248	ABC-ATPase subunit interface; other site
635013000249	NMT1-like family; Region: NMT1_2; cl15260
635013000250	NMT1/THI5 like; Region: NMT1; pfam09084
635013000251	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
635013000252	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
635013000253	Walker A/P-loop; other site
635013000254	ATP binding site [chemical binding]; other site
635013000255	Q-loop/lid; other site
635013000256	ABC transporter signature motif; other site
635013000257	Walker B; other site
635013000258	D-loop; other site
635013000259	H-loop/switch region; other site
635013000260	Thiamine pyrophosphokinase; Region: TPK; cd07995
635013000261	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
635013000262	active site
635013000263	dimerization interface [polypeptide binding]; other site
635013000264	thiamine binding site [chemical binding]; other site
635013000265	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
635013000266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000267	Walker A motif; other site
635013000268	ATP binding site [chemical binding]; other site
635013000269	Walker B motif; other site
635013000270	arginine finger; other site
635013000271	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
635013000272	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
635013000273	recombination protein RecR; Reviewed; Region: recR; PRK00076
635013000274	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
635013000275	RecR protein; Region: RecR; pfam02132
635013000276	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
635013000277	putative active site [active]
635013000278	putative metal-binding site [ion binding]; other site
635013000279	tetramer interface [polypeptide binding]; other site
635013000280	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
635013000281	NeuB family; Region: NeuB; cl00496
635013000282	prephenate dehydratase; Provisional; Region: PRK11898
635013000283	Prephenate dehydratase; Region: PDT; pfam00800
635013000284	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
635013000285	putative L-Phe binding site [chemical binding]; other site
635013000286	Chorismate mutase type II; Region: CM_2; cl00693
635013000287	SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466
635013000288	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
635013000289	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
635013000290	dimer interface [polypeptide binding]; other site
635013000291	PYR/PP interface [polypeptide binding]; other site
635013000292	TPP binding site [chemical binding]; other site
635013000293	substrate binding site [chemical binding]; other site
635013000294	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
635013000295	TPP-binding site [chemical binding]; other site
635013000296	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
635013000297	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
635013000298	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013000299	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013000300	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
635013000301	active site
635013000302	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
635013000303	N-acetyl-D-glucosamine binding site [chemical binding]; other site
635013000304	catalytic residue [active]
635013000305	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
635013000306	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
635013000307	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
635013000308	homodimer interface [polypeptide binding]; other site
635013000309	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013000310	catalytic residue [active]
635013000311	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
635013000312	thymidylate kinase; Validated; Region: tmk; PRK00698
635013000313	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
635013000314	TMP-binding site; other site
635013000315	ATP-binding site [chemical binding]; other site
635013000316	Protein of unknown function (DUF327); Region: DUF327; cl00753
635013000317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000318	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
635013000319	Walker A motif; other site
635013000320	ATP binding site [chemical binding]; other site
635013000321	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013000322	PSP1 C-terminal conserved region; Region: PSP1; cl00770
635013000323	Protein of unknown function (DUF972); Region: DUF972; pfam06156
635013000324	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
635013000325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013000326	S-adenosylmethionine binding site [chemical binding]; other site
635013000327	Predicted methyltransferases [General function prediction only]; Region: COG0313
635013000328	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
635013000329	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
635013000330	Transposase domain (DUF772); Region: DUF772; cl15789
635013000331	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013000332	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
635013000333	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
635013000334	active site
635013000335	HIGH motif; other site
635013000336	KMSKS motif; other site
635013000337	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
635013000338	tRNA binding surface [nucleotide binding]; other site
635013000339	anticodon binding site; other site
635013000340	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
635013000341	dimer interface [polypeptide binding]; other site
635013000342	putative tRNA-binding site [nucleotide binding]; other site
635013000343	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
635013000344	active site
635013000345	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
635013000346	Domain of unknown function (DUF348); Region: DUF348; pfam03990
635013000347	Domain of unknown function (DUF348); Region: DUF348; pfam03990
635013000348	G5 domain; Region: G5; pfam07501
635013000349	3D domain; Region: 3D; cl01439
635013000350	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013000351	S-adenosylmethionine binding site [chemical binding]; other site
635013000352	YabG peptidase U57; Region: Peptidase_U57; cl05250
635013000353	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
635013000354	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013000355	NAD(P) binding site [chemical binding]; other site
635013000356	active site
635013000357	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013000358	putative peptidoglycan binding site; other site
635013000359	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013000360	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013000361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
635013000362	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
635013000363	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
635013000364	putative CheA interaction surface; other site
635013000365	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
635013000366	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
635013000367	putative binding surface; other site
635013000368	active site
635013000369	P2 response regulator binding domain; Region: P2; pfam07194
635013000370	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
635013000371	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
635013000372	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
635013000373	Response regulator receiver domain; Region: Response_reg; pfam00072
635013000374	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013000375	active site
635013000376	phosphorylation site [posttranslational modification]
635013000377	intermolecular recognition site; other site
635013000378	dimerization interface [polypeptide binding]; other site
635013000379	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
635013000380	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013000381	active site
635013000382	phosphorylation site [posttranslational modification]
635013000383	intermolecular recognition site; other site
635013000384	dimerization interface [polypeptide binding]; other site
635013000385	CheB methylesterase; Region: CheB_methylest; pfam01339
635013000386	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
635013000387	Chemotaxis phosphatase CheX; Region: CheX; cl15816
635013000388	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
635013000389	Chemotaxis phosphatase CheX; Region: CheX; cl15816
635013000390	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013000391	dimerization interface [polypeptide binding]; other site
635013000392	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013000393	dimer interface [polypeptide binding]; other site
635013000394	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013000395	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013000396	dimer interface [polypeptide binding]; other site
635013000397	putative CheW interface [polypeptide binding]; other site
635013000398	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
635013000399	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
635013000400	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cl03439
635013000401	heme-binding residues [chemical binding]; other site
635013000402	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
635013000403	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013000404	binding surface
635013000405	TPR motif; other site
635013000406	NHL repeat; Region: NHL; pfam01436
635013000407	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
635013000408	NHL repeat; Region: NHL; pfam01436
635013000409	NHL repeat; Region: NHL; pfam01436
635013000410	NHL repeat; Region: NHL; pfam01436
635013000411	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013000412	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013000413	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013000414	CHASE3 domain; Region: CHASE3; cl05000
635013000415	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013000416	dimerization interface [polypeptide binding]; other site
635013000417	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013000418	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013000419	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013000420	dimer interface [polypeptide binding]; other site
635013000421	putative CheW interface [polypeptide binding]; other site
635013000422	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
635013000423	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
635013000424	proposed catalytic triad [active]
635013000425	active site nucleophile [active]
635013000426	cyanophycin synthetase; Provisional; Region: PRK14016
635013000427	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013000428	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013000429	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
635013000430	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
635013000431	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
635013000432	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
635013000433	Transcriptional regulators [Transcription]; Region: GntR; COG1802
635013000434	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
635013000435	DNA-binding site [nucleotide binding]; DNA binding site
635013000436	FCD domain; Region: FCD; cl11656
635013000437	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
635013000438	active site
635013000439	SpoVG; Region: SpoVG; cl00915
635013000440	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
635013000441	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
635013000442	Substrate binding site; other site
635013000443	Mg++ binding site; other site
635013000444	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
635013000445	active site
635013000446	substrate binding site [chemical binding]; other site
635013000447	CoA binding site [chemical binding]; other site
635013000448	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
635013000449	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
635013000450	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013000451	active site
635013000452	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
635013000453	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
635013000454	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
635013000455	PemK-like protein; Region: PemK; cl00995
635013000456	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
635013000457	S-layer homology domain; Region: SLH; pfam00395
635013000458	S-layer homology domain; Region: SLH; pfam00395
635013000459	S-layer homology domain; Region: SLH; pfam00395
635013000460	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
635013000461	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
635013000462	NMT1-like family; Region: NMT1_2; cl15260
635013000463	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
635013000464	methyltransferase, MtaA/CmuA family; Region: mtaA_cmuA; TIGR01463
635013000465	The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465
635013000466	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013000467	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013000468	B12 binding site [chemical binding]; other site
635013000469	cobalt ligand [ion binding]; other site
635013000470	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
635013000471	tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979
635013000472	Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798
635013000473	HPP family; Region: HPP; pfam04982
635013000474	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
635013000475	MEDS: MEthanogen/methylotroph, DcmR Sensory domain; Region: MEDS; pfam14417
635013000476	4Fe-4S binding domain; Region: Fer4_5; pfam12801
635013000477	4Fe-4S binding domain; Region: Fer4_5; pfam12801
635013000478	4Fe-4S binding domain; Region: Fer4; cl02805
635013000479	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
635013000480	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
635013000481	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
635013000482	RNA binding surface [nucleotide binding]; other site
635013000483	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
635013000484	active site
635013000485	uracil binding [chemical binding]; other site
635013000486	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
635013000487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
635013000488	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283
635013000489	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
635013000490	active site
635013000491	metal binding site [ion binding]; metal-binding site
635013000492	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
635013000493	Helix-turn-helix domains; Region: HTH; cl00088
635013000494	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
635013000495	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
635013000496	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
635013000497	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
635013000498	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
635013000499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
635013000500	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
635013000501	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013000502	S-adenosylmethionine binding site [chemical binding]; other site
635013000503	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283
635013000504	4Fe-4S binding domain; Region: Fer4_5; pfam12801
635013000505	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
635013000506	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013000507	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
635013000508	Helix-turn-helix domains; Region: HTH; cl00088
635013000509	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
635013000510	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013000511	putative peptidoglycan binding site; other site
635013000512	G5 domain; Region: G5; pfam07501
635013000513	Peptidase family M23; Region: Peptidase_M23; pfam01551
635013000514	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
635013000515	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013000516	TPR motif; other site
635013000517	binding surface
635013000518	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
635013000519	Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823
635013000520	BON domain; Region: BON; cl02771
635013000521	BON domain; Region: BON; cl02771
635013000522	BON domain; Region: BON; cl02771
635013000523	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
635013000524	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
635013000525	hinge; other site
635013000526	active site
635013000527	NADH dehydrogenase subunit 5 C-terminus; Region: NADH5_C; pfam06455
635013000528	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
635013000529	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013000530	dimer interface [polypeptide binding]; other site
635013000531	putative CheW interface [polypeptide binding]; other site
635013000532	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013000533	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013000534	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013000535	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
635013000536	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
635013000537	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013000538	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013000539	dimer interface [polypeptide binding]; other site
635013000540	putative CheW interface [polypeptide binding]; other site
635013000541	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
635013000542	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
635013000543	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
635013000544	protein binding site [polypeptide binding]; other site
635013000545	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
635013000546	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013000547	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013000548	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
635013000549	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
635013000550	5S rRNA interface [nucleotide binding]; other site
635013000551	CTC domain interface [polypeptide binding]; other site
635013000552	L16 interface [polypeptide binding]; other site
635013000553	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
635013000554	putative active site [active]
635013000555	catalytic residue [active]
635013000556	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
635013000557	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
635013000558	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013000559	ATP binding site [chemical binding]; other site
635013000560	putative Mg++ binding site [ion binding]; other site
635013000561	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013000562	nucleotide binding region [chemical binding]; other site
635013000563	ATP-binding site [chemical binding]; other site
635013000564	TRCF domain; Region: TRCF; cl04088
635013000565	SurA N-terminal domain; Region: SurA_N_3; cl07813
635013000566	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
635013000567	PPIC-type PPIASE domain; Region: Rotamase; cl08278
635013000568	stage V sporulation protein T; Region: spore_V_T; TIGR02851
635013000569	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
635013000570	GAF domain; Region: GAF; cl15785
635013000571	MatE; Region: MatE; cl10513
635013000572	stage V sporulation protein B; Region: spore_V_B; TIGR02900
635013000573	MatE; Region: MatE; cl10513
635013000574	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
635013000575	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
635013000576	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
635013000577	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
635013000578	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
635013000579	IHF dimer interface [polypeptide binding]; other site
635013000580	IHF - DNA interface [nucleotide binding]; other site
635013000581	Cache domain; Region: Cache_1; pfam02743
635013000582	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
635013000583	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013000584	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013000585	dimer interface [polypeptide binding]; other site
635013000586	putative CheW interface [polypeptide binding]; other site
635013000587	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
635013000588	Stage II sporulation protein; Region: SpoIID; pfam08486
635013000589	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
635013000590	YabP family; Region: YabP; cl06766
635013000591	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
635013000592	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
635013000593	hypothetical protein; Provisional; Region: PRK08582
635013000594	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
635013000595	RNA binding site [nucleotide binding]; other site
635013000596	Transposase domain (DUF772); Region: DUF772; cl15789
635013000597	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013000598	Helix-turn-helix domains; Region: HTH; cl00088
635013000599	Bacterial transcriptional repressor; Region: TetR_C_6; cl07106
635013000600	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
635013000601	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
635013000602	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
635013000603	active site
635013000604	substrate binding site [chemical binding]; other site
635013000605	metal binding site [ion binding]; metal-binding site
635013000606	stage II sporulation protein E; Region: spore_II_E; TIGR02865
635013000607	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
635013000608	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013000609	ATP binding site [chemical binding]; other site
635013000610	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
635013000611	B3/4 domain; Region: B3_4; cl11458
635013000612	FtsH Extracellular; Region: FtsH_ext; pfam06480
635013000613	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
635013000614	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000615	Walker A motif; other site
635013000616	ATP binding site [chemical binding]; other site
635013000617	Walker B motif; other site
635013000618	arginine finger; other site
635013000619	Peptidase family M41; Region: Peptidase_M41; pfam01434
635013000620	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
635013000621	active site
635013000622	multimer interface [polypeptide binding]; other site
635013000623	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
635013000624	subunit interaction site [polypeptide binding]; other site
635013000625	PHB binding site; other site
635013000626	CoenzymeA binding site [chemical binding]; other site
635013000627	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
635013000628	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
635013000629	Potassium binding sites [ion binding]; other site
635013000630	Cesium cation binding sites [ion binding]; other site
635013000631	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013000632	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
635013000633	dihydropteroate synthase; Region: DHPS; TIGR01496
635013000634	substrate binding pocket [chemical binding]; other site
635013000635	dimer interface [polypeptide binding]; other site
635013000636	inhibitor binding site; inhibition site
635013000637	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
635013000638	homooctamer interface [polypeptide binding]; other site
635013000639	active site
635013000640	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
635013000641	catalytic center binding site [active]
635013000642	ATP binding site [chemical binding]; other site
635013000643	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013000644	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
635013000645	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
635013000646	active site
635013000647	oligomerization interface [polypeptide binding]; other site
635013000648	metal binding site [ion binding]; metal-binding site
635013000649	pantoate--beta-alanine ligase; Region: panC; TIGR00018
635013000650	Pantoate-beta-alanine ligase; Region: PanC; cd00560
635013000651	active site
635013000652	ATP-binding site [chemical binding]; other site
635013000653	pantoate-binding site; other site
635013000654	HXXH motif; other site
635013000655	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
635013000656	tetramerization interface [polypeptide binding]; other site
635013000657	active site
635013000658	Quinolinate synthetase A protein; Region: NadA; cl00420
635013000659	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
635013000660	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013000661	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
635013000662	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
635013000663	nicotinate-nucleotide pyrophosphorylase; Region: nadC; TIGR00078
635013000664	dimerization interface [polypeptide binding]; other site
635013000665	active site
635013000666	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
635013000667	Helix-turn-helix domains; Region: HTH; cl00088
635013000668	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
635013000669	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
635013000670	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
635013000671	Mg-chelatase subunit ChlD [Coenzyme metabolism]; Region: ChlD; COG1240
635013000672	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
635013000673	metal ion-dependent adhesion site (MIDAS); other site
635013000674	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
635013000675	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000676	ATP binding site [chemical binding]; other site
635013000677	Walker A motif; other site
635013000678	Walker B motif; other site
635013000679	arginine finger; other site
635013000680	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
635013000681	Chemotaxis phosphatase CheX; Region: CheX; cl15816
635013000682	Type III pantothenate kinase; Region: Pan_kinase; cl09130
635013000683	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
635013000684	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
635013000685	FMN binding site [chemical binding]; other site
635013000686	active site
635013000687	catalytic residues [active]
635013000688	substrate binding site [chemical binding]; other site
635013000689	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
635013000690	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
635013000691	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
635013000692	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
635013000693	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
635013000694	dimer interface [polypeptide binding]; other site
635013000695	putative anticodon binding site; other site
635013000696	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
635013000697	motif 1; other site
635013000698	active site
635013000699	motif 2; other site
635013000700	motif 3; other site
635013000701	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
635013000702	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
635013000703	3-ketosteroid-delta-1-dehydrogenase; Reviewed; Region: PRK07843
635013000704	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
635013000705	Helix-turn-helix domains; Region: HTH; cl00088
635013000706	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
635013000707	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
635013000708	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013000709	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
635013000710	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013000711	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
635013000712	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
635013000713	UvrB/uvrC motif; Region: UVR; pfam02151
635013000714	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
635013000715	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
635013000716	ADP binding site [chemical binding]; other site
635013000717	phosphagen binding site; other site
635013000718	substrate specificity loop; other site
635013000719	Clp protease ATP binding subunit; Region: clpC; CHL00095
635013000720	Clp amino terminal domain; Region: Clp_N; pfam02861
635013000721	Clp amino terminal domain; Region: Clp_N; pfam02861
635013000722	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000723	Walker A motif; other site
635013000724	ATP binding site [chemical binding]; other site
635013000725	Walker B motif; other site
635013000726	arginine finger; other site
635013000727	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013000728	Walker A motif; other site
635013000729	ATP binding site [chemical binding]; other site
635013000730	Walker B motif; other site
635013000731	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
635013000732	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
635013000733	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
635013000734	putative active site [active]
635013000735	putative NTP binding site [chemical binding]; other site
635013000736	putative nucleic acid binding site [nucleotide binding]; other site
635013000737	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
635013000738	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
635013000739	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
635013000740	DNA repair protein RadA; Provisional; Region: PRK11823
635013000741	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
635013000742	Walker A motif/ATP binding site; other site
635013000743	ATP binding site [chemical binding]; other site
635013000744	Walker B motif; other site
635013000745	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
635013000746	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
635013000747	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
635013000748	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
635013000749	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
635013000750	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
635013000751	CobD/Cbib protein; Region: CobD_Cbib; cl00561
635013000752	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
635013000753	putative active site [active]
635013000754	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
635013000755	substrate binding site; other site
635013000756	dimer interface; other site
635013000757	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
635013000758	homotrimer interaction site [polypeptide binding]; other site
635013000759	zinc binding site [ion binding]; other site
635013000760	CDP-binding sites; other site
635013000761	PrcB C-terminal; Region: PrcB_C; pfam14343
635013000762	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
635013000763	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
635013000764	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
635013000765	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
635013000766	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
635013000767	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
635013000768	putative substrate-binding site; other site
635013000769	nickel binding site [ion binding]; other site
635013000770	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
635013000771	Helix-turn-helix domains; Region: HTH; cl00088
635013000772	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
635013000773	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013000774	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
635013000775	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013000776	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
635013000777	ABC-2 type transporter; Region: ABC2_membrane; cl11417
635013000778	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
635013000779	Flagellar protein FliT; Region: FliT; cl05125
635013000780	Transposase domain (DUF772); Region: DUF772; cl15789
635013000781	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013000782	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
635013000783	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
635013000784	active site
635013000785	HIGH motif; other site
635013000786	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
635013000787	active site
635013000788	KMSKS motif; other site
635013000789	serine O-acetyltransferase; Region: cysE; TIGR01172
635013000790	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
635013000791	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
635013000792	trimer interface [polypeptide binding]; other site
635013000793	active site
635013000794	substrate binding site [chemical binding]; other site
635013000795	CoA binding site [chemical binding]; other site
635013000796	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
635013000797	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
635013000798	active site
635013000799	HIGH motif; other site
635013000800	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
635013000801	KMSKS motif; other site
635013000802	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
635013000803	tRNA binding surface [nucleotide binding]; other site
635013000804	anticodon binding site; other site
635013000805	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
635013000806	active site
635013000807	metal binding site [ion binding]; metal-binding site
635013000808	dimerization interface [polypeptide binding]; other site
635013000809	Thymidylate synthase complementing protein; Region: Thy1; cl03630
635013000810	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
635013000811	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
635013000812	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
635013000813	YacP-like NYN domain; Region: NYN_YacP; cl01491
635013000814	RNA polymerase factor sigma-70; Validated; Region: PRK08295
635013000815	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013000816	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
635013000817	elongation factor Tu; Reviewed; Region: PRK00049
635013000818	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
635013000819	G1 box; other site
635013000820	GEF interaction site [polypeptide binding]; other site
635013000821	GTP/Mg2+ binding site [chemical binding]; other site
635013000822	Switch I region; other site
635013000823	G2 box; other site
635013000824	G3 box; other site
635013000825	Switch II region; other site
635013000826	G4 box; other site
635013000827	G5 box; other site
635013000828	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
635013000829	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
635013000830	Antibiotic Binding Site [chemical binding]; other site
635013000831	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
635013000832	Helix-turn-helix domains; Region: HTH; cl00088
635013000833	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
635013000834	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
635013000835	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
635013000836	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
635013000837	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
635013000838	putative homodimer interface [polypeptide binding]; other site
635013000839	KOW motif; Region: KOW; cl00354
635013000840	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
635013000841	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
635013000842	23S rRNA interface [nucleotide binding]; other site
635013000843	L7/L12 interface [polypeptide binding]; other site
635013000844	putative thiostrepton binding site; other site
635013000845	L25 interface [polypeptide binding]; other site
635013000846	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
635013000847	mRNA/rRNA interface [nucleotide binding]; other site
635013000848	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
635013000849	23S rRNA interface [nucleotide binding]; other site
635013000850	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
635013000851	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
635013000852	peripheral dimer interface [polypeptide binding]; other site
635013000853	core dimer interface [polypeptide binding]; other site
635013000854	L10 interface [polypeptide binding]; other site
635013000855	L11 interface [polypeptide binding]; other site
635013000856	putative EF-Tu interaction site [polypeptide binding]; other site
635013000857	putative EF-G interaction site [polypeptide binding]; other site
635013000858	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
635013000859	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
635013000860	RPB12 interaction site [polypeptide binding]; other site
635013000861	RPB1 interaction site [polypeptide binding]; other site
635013000862	RPB10 interaction site [polypeptide binding]; other site
635013000863	RPB11 interaction site [polypeptide binding]; other site
635013000864	RPB3 interaction site [polypeptide binding]; other site
635013000865	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
635013000866	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
635013000867	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
635013000868	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
635013000869	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
635013000870	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
635013000871	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
635013000872	G-loop; other site
635013000873	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
635013000874	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
635013000875	DNA binding site [nucleotide binding]
635013000876	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
635013000877	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
635013000878	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
635013000879	S17 interaction site [polypeptide binding]; other site
635013000880	S8 interaction site; other site
635013000881	16S rRNA interaction site [nucleotide binding]; other site
635013000882	streptomycin interaction site [chemical binding]; other site
635013000883	23S rRNA interaction site [nucleotide binding]; other site
635013000884	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
635013000885	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
635013000886	elongation factor G; Reviewed; Region: PRK00007
635013000887	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
635013000888	G1 box; other site
635013000889	putative GEF interaction site [polypeptide binding]; other site
635013000890	GTP/Mg2+ binding site [chemical binding]; other site
635013000891	Switch I region; other site
635013000892	G2 box; other site
635013000893	G3 box; other site
635013000894	Switch II region; other site
635013000895	G4 box; other site
635013000896	G5 box; other site
635013000897	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
635013000898	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
635013000899	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
635013000900	elongation factor Tu; Reviewed; Region: PRK00049
635013000901	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
635013000902	G1 box; other site
635013000903	GEF interaction site [polypeptide binding]; other site
635013000904	GTP/Mg2+ binding site [chemical binding]; other site
635013000905	Switch I region; other site
635013000906	G2 box; other site
635013000907	G3 box; other site
635013000908	Switch II region; other site
635013000909	G4 box; other site
635013000910	G5 box; other site
635013000911	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
635013000912	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
635013000913	Antibiotic Binding Site [chemical binding]; other site
635013000914	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
635013000915	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
635013000916	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
635013000917	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
635013000918	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
635013000919	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
635013000920	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
635013000921	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
635013000922	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
635013000923	putative translocon binding site; other site
635013000924	protein-rRNA interface [nucleotide binding]; other site
635013000925	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
635013000926	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
635013000927	G-X-X-G motif; other site
635013000928	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
635013000929	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
635013000930	23S rRNA interface [nucleotide binding]; other site
635013000931	5S rRNA interface [nucleotide binding]; other site
635013000932	putative antibiotic binding site [chemical binding]; other site
635013000933	L25 interface [polypeptide binding]; other site
635013000934	L27 interface [polypeptide binding]; other site
635013000935	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
635013000936	23S rRNA interface [nucleotide binding]; other site
635013000937	putative translocon interaction site; other site
635013000938	signal recognition particle (SRP54) interaction site; other site
635013000939	L23 interface [polypeptide binding]; other site
635013000940	trigger factor interaction site; other site
635013000941	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
635013000942	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
635013000943	KOW motif; Region: KOW; cl00354
635013000944	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
635013000945	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
635013000946	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
635013000947	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
635013000948	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
635013000949	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
635013000950	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
635013000951	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
635013000952	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
635013000953	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
635013000954	5S rRNA interface [nucleotide binding]; other site
635013000955	L27 interface [polypeptide binding]; other site
635013000956	23S rRNA interface [nucleotide binding]; other site
635013000957	L5 interface [polypeptide binding]; other site
635013000958	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
635013000959	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
635013000960	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
635013000961	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
635013000962	23S rRNA binding site [nucleotide binding]; other site
635013000963	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
635013000964	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
635013000965	SecY translocase; Region: SecY; pfam00344
635013000966	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
635013000967	active site
635013000968	Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163
635013000969	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
635013000970	rRNA binding site [nucleotide binding]; other site
635013000971	predicted 30S ribosome binding site; other site
635013000972	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
635013000973	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
635013000974	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
635013000975	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
635013000976	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
635013000977	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
635013000978	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
635013000979	RNA binding surface [nucleotide binding]; other site
635013000980	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
635013000981	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
635013000982	alphaNTD - beta interaction site [polypeptide binding]; other site
635013000983	alphaNTD homodimer interface [polypeptide binding]; other site
635013000984	alphaNTD - beta' interaction site [polypeptide binding]; other site
635013000985	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
635013000986	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
635013000987	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
635013000988	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
635013000989	Walker A/P-loop; other site
635013000990	ATP binding site [chemical binding]; other site
635013000991	Q-loop/lid; other site
635013000992	ABC transporter signature motif; other site
635013000993	Walker B; other site
635013000994	D-loop; other site
635013000995	H-loop/switch region; other site
635013000996	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
635013000997	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
635013000998	Walker A/P-loop; other site
635013000999	ATP binding site [chemical binding]; other site
635013001000	Q-loop/lid; other site
635013001001	ABC transporter signature motif; other site
635013001002	Walker B; other site
635013001003	D-loop; other site
635013001004	H-loop/switch region; other site
635013001005	Cobalt transport protein; Region: CbiQ; cl00463
635013001006	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
635013001007	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
635013001008	dimerization interface 3.5A [polypeptide binding]; other site
635013001009	active site
635013001010	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
635013001011	23S rRNA interface [nucleotide binding]; other site
635013001012	L3 interface [polypeptide binding]; other site
635013001013	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
635013001014	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
635013001015	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
635013001016	active site
635013001017	metal binding site [ion binding]; metal-binding site
635013001018	hypothetical protein; Provisional; Region: PRK03881
635013001019	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
635013001020	AMMECR1; Region: AMMECR1; cl00911
635013001021	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
635013001022	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013001023	FeS/SAM binding site; other site
635013001024	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
635013001025	iron binding site [ion binding]; other site
635013001026	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
635013001027	dinuclear metal binding motif [ion binding]; other site
635013001028	EamA-like transporter family; Region: EamA; cl01037
635013001029	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
635013001030	EamA-like transporter family; Region: EamA; cl01037
635013001031	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
635013001032	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
635013001033	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
635013001034	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
635013001035	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
635013001036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013001037	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
635013001038	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
635013001039	heterotetramer interface [polypeptide binding]; other site
635013001040	active site pocket [active]
635013001041	cleavage site
635013001042	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013001043	FeS/SAM binding site; other site
635013001044	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
635013001045	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
635013001046	feedback inhibition sensing region; other site
635013001047	homohexameric interface [polypeptide binding]; other site
635013001048	nucleotide binding site [chemical binding]; other site
635013001049	N-acetyl-L-glutamate binding site [chemical binding]; other site
635013001050	acetylornithine aminotransferase; Provisional; Region: PRK02627
635013001051	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
635013001052	inhibitor-cofactor binding pocket; inhibition site
635013001053	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013001054	catalytic residue [active]
635013001055	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
635013001056	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
635013001057	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
635013001058	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
635013001059	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013001060	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
635013001061	IMP binding site; other site
635013001062	dimer interface [polypeptide binding]; other site
635013001063	interdomain contacts; other site
635013001064	partial ornithine binding site; other site
635013001065	ornithine carbamoyltransferase; Provisional; Region: PRK00779
635013001066	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
635013001067	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013001068	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
635013001069	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
635013001070	ANP binding site [chemical binding]; other site
635013001071	Substrate Binding Site II [chemical binding]; other site
635013001072	Substrate Binding Site I [chemical binding]; other site
635013001073	argininosuccinate lyase; Provisional; Region: PRK00855
635013001074	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
635013001075	active sites [active]
635013001076	tetramer interface [polypeptide binding]; other site
635013001077	aspartate kinase I; Reviewed; Region: PRK08210
635013001078	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
635013001079	nucleotide binding site [chemical binding]; other site
635013001080	substrate binding site [chemical binding]; other site
635013001081	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
635013001082	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
635013001083	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
635013001084	homodimer interface [polypeptide binding]; other site
635013001085	substrate-cofactor binding pocket; other site
635013001086	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013001087	catalytic residue [active]
635013001088	Dehydratase family; Region: ILVD_EDD; cl00340
635013001089	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
635013001090	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
635013001091	PYR/PP interface [polypeptide binding]; other site
635013001092	dimer interface [polypeptide binding]; other site
635013001093	TPP binding site [chemical binding]; other site
635013001094	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
635013001095	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
635013001096	TPP-binding site [chemical binding]; other site
635013001097	dimer interface [polypeptide binding]; other site
635013001098	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
635013001099	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
635013001100	putative valine binding site [chemical binding]; other site
635013001101	dimer interface [polypeptide binding]; other site
635013001102	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
635013001103	ketol-acid reductoisomerase; Provisional; Region: PRK05479
635013001104	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013001105	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
635013001106	2-isopropylmalate synthase; Validated; Region: PRK00915
635013001107	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
635013001108	active site
635013001109	catalytic residues [active]
635013001110	metal binding site [ion binding]; metal-binding site
635013001111	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
635013001112	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
635013001113	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
635013001114	substrate binding site [chemical binding]; other site
635013001115	ligand binding site [chemical binding]; other site
635013001116	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
635013001117	substrate binding site [chemical binding]; other site
635013001118	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
635013001119	tartrate dehydrogenase; Provisional; Region: PRK08194
635013001120	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
635013001121	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
635013001122	active site
635013001123	catalytic residues [active]
635013001124	metal binding site [ion binding]; metal-binding site
635013001125	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
635013001126	acetyl-CoA synthetase; Provisional; Region: PRK00174
635013001127	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
635013001128	AMP-binding enzyme; Region: AMP-binding; cl15778
635013001129	AMP-binding enzyme; Region: AMP-binding; cl15778
635013001130	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013001131	acetyl-CoA synthetase; Provisional; Region: PRK00174
635013001132	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
635013001133	AMP-binding enzyme; Region: AMP-binding; cl15778
635013001134	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013001135	acetyl-CoA synthetase; Provisional; Region: PRK04319
635013001136	AMP-binding enzyme; Region: AMP-binding; cl15778
635013001137	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013001138	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
635013001139	N-acetyl-D-glucosamine binding site [chemical binding]; other site
635013001140	catalytic residue [active]
635013001141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
635013001142	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
635013001143	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
635013001144	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
635013001145	Uncharacterized conserved protein [Function unknown]; Region: COG1624
635013001146	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
635013001147	YbbR-like protein; Region: YbbR; pfam07949
635013001148	YbbR-like protein; Region: YbbR; pfam07949
635013001149	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
635013001150	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
635013001151	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
635013001152	active site
635013001153	substrate binding site [chemical binding]; other site
635013001154	metal binding site [ion binding]; metal-binding site
635013001155	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
635013001156	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
635013001157	glutaminase active site [active]
635013001158	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
635013001159	dimer interface [polypeptide binding]; other site
635013001160	active site
635013001161	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
635013001162	dimer interface [polypeptide binding]; other site
635013001163	active site
635013001164	SAF domain; Region: SAF; cl00555
635013001165	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
635013001166	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
635013001167	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
635013001168	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
635013001169	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
635013001170	ATP binding site [chemical binding]; other site
635013001171	Walker A motif; other site
635013001172	hexamer interface [polypeptide binding]; other site
635013001173	Walker B motif; other site
635013001174	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
635013001175	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013001176	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013001177	S-layer homology domain; Region: SLH; pfam00395
635013001178	S-layer homology domain; Region: SLH; pfam00395
635013001179	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
635013001180	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013001181	sequence-specific DNA binding site [nucleotide binding]; other site
635013001182	salt bridge; other site
635013001183	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013001184	metal binding site [ion binding]; metal-binding site
635013001185	active site
635013001186	I-site; other site
635013001187	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
635013001188	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
635013001189	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
635013001190	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
635013001191	Walker A/P-loop; other site
635013001192	ATP binding site [chemical binding]; other site
635013001193	Q-loop/lid; other site
635013001194	ABC transporter signature motif; other site
635013001195	Walker B; other site
635013001196	D-loop; other site
635013001197	H-loop/switch region; other site
635013001198	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013001199	dimer interface [polypeptide binding]; other site
635013001200	conserved gate region; other site
635013001201	putative PBP binding loops; other site
635013001202	ABC-ATPase subunit interface; other site
635013001203	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
635013001204	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
635013001205	substrate binding pocket [chemical binding]; other site
635013001206	membrane-bound complex binding site; other site
635013001207	hinge residues; other site
635013001208	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
635013001209	Protein of unknown function (DUF421); Region: DUF421; cl00990
635013001210	Putative glucoamylase; Region: Glycoamylase; pfam10091
635013001211	Putative carbohydrate binding domain; Region: CBM_X; cl05621
635013001212	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
635013001213	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
635013001214	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
635013001215	Putative carbohydrate binding domain; Region: CBM_X; cl05621
635013001216	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
635013001217	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
635013001218	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
635013001219	SEC-C motif; Region: SEC-C; pfam02810
635013001220	cellulose synthase subunit BcsC; Provisional; Region: PRK11447
635013001221	methyl-accepting protein IV; Provisional; Region: PRK09793
635013001222	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013001223	metal binding site [ion binding]; metal-binding site
635013001224	active site
635013001225	I-site; other site
635013001226	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
635013001227	4Fe-4S binding domain; Region: Fer4; cl02805
635013001228	Ribosomal L40e family; Region: Ribosomal_L40e; cl00671
635013001229	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
635013001230	AAA ATPase domain; Region: AAA_15; pfam13175
635013001231	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
635013001232	ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules.  The...; Region: ABC_ATPase; cd00267
635013001233	Walker B; other site
635013001234	D-loop; other site
635013001235	H-loop/switch region; other site
635013001236	HerA helicase [Replication, recombination, and repair]; Region: COG0433
635013001237	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
635013001238	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
635013001239	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
635013001240	nucleotide binding site/active site [active]
635013001241	HIT family signature motif; other site
635013001242	catalytic residue [active]
635013001243	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
635013001244	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013001245	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
635013001246	Protein of unknown function (DUF524); Region: DUF524; pfam04411
635013001247	Rubrerythrin [Energy production and conversion]; Region: COG1592
635013001248	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
635013001249	binuclear metal center [ion binding]; other site
635013001250	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
635013001251	iron binding site [ion binding]; other site
635013001252	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
635013001253	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
635013001254	non-heme iron binding site [ion binding]; other site
635013001255	dimer interface [polypeptide binding]; other site
635013001256	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
635013001257	non-heme iron binding site [ion binding]; other site
635013001258	dimer interface [polypeptide binding]; other site
635013001259	Polycystin cation channel protein; Provisional; Region: PLN03223
635013001260	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
635013001261	dimerization interface [polypeptide binding]; other site
635013001262	putative DNA binding site [nucleotide binding]; other site
635013001263	putative Zn2+ binding site [ion binding]; other site
635013001264	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
635013001265	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
635013001266	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
635013001267	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
635013001268	AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586
635013001269	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
635013001270	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
635013001271	Helix-turn-helix domains; Region: HTH; cl00088
635013001272	Methyltransferase domain; Region: Methyltransf_31; pfam13847
635013001273	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013001274	S-adenosylmethionine binding site [chemical binding]; other site
635013001275	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
635013001276	dimerization interface [polypeptide binding]; other site
635013001277	putative DNA binding site [nucleotide binding]; other site
635013001278	putative Zn2+ binding site [ion binding]; other site
635013001279	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
635013001280	3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493
635013001281	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
635013001282	active site residue [active]
635013001283	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
635013001284	active site residue [active]
635013001285	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
635013001286	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013001287	putative substrate translocation pore; other site
635013001288	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
635013001289	Cation efflux family; Region: Cation_efflux; cl00316
635013001290	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
635013001291	dimerization interface [polypeptide binding]; other site
635013001292	putative DNA binding site [nucleotide binding]; other site
635013001293	putative Zn2+ binding site [ion binding]; other site
635013001294	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
635013001295	Predicted permeases [General function prediction only]; Region: COG0701
635013001296	Predicted permease; Region: DUF318; pfam03773
635013001297	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
635013001298	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
635013001299	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
635013001300	catalytic residue [active]
635013001301	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4871
635013001302	Putative Fe-S cluster; Region: FeS; pfam04060
635013001303	Predicted permeases [General function prediction only]; Region: COG0701
635013001304	Predicted permease; Region: DUF318; pfam03773
635013001305	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
635013001306	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013001307	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013001308	DNA binding residues [nucleotide binding]
635013001309	Domain of unknown function (DUF2703); Region: DUF2703; pfam10865
635013001310	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
635013001311	catalytic residues [active]
635013001312	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
635013001313	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
635013001314	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
635013001315	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
635013001316	putative DNA binding site [nucleotide binding]; other site
635013001317	dimerization interface [polypeptide binding]; other site
635013001318	putative Zn2+ binding site [ion binding]; other site
635013001319	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
635013001320	Membrane transport protein; Region: Mem_trans; cl09117
635013001321	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
635013001322	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
635013001323	active site
635013001324	metal binding site [ion binding]; metal-binding site
635013001325	homotetramer interface [polypeptide binding]; other site
635013001326	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
635013001327	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
635013001328	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
635013001329	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
635013001330	active site
635013001331	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
635013001332	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
635013001333	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
635013001334	Integrase core domain; Region: rve; cl01316
635013001335	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
635013001336	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
635013001337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013001338	Walker A motif; other site
635013001339	ATP binding site [chemical binding]; other site
635013001340	Walker B motif; other site
635013001341	arginine finger; other site
635013001342	integral membrane protein MviN; Region: mviN; TIGR01695
635013001343	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
635013001344	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013001345	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013001346	DNA binding residues [nucleotide binding]
635013001347	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
635013001348	Putative zinc-finger; Region: zf-HC2; cl15806
635013001349	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
635013001350	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
635013001351	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
635013001352	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
635013001353	putative inner membrane protein; Provisional; Region: PRK11099
635013001354	Sulphur transport; Region: Sulf_transp; cl01018
635013001355	Sulphur transport; Region: Sulf_transp; cl01018
635013001356	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; cl09920
635013001357	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
635013001358	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
635013001359	substrate binding site; other site
635013001360	tetramer interface; other site
635013001361	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
635013001362	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
635013001363	inhibitor-cofactor binding pocket; inhibition site
635013001364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013001365	catalytic residue [active]
635013001366	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
635013001367	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013001368	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
635013001369	active site residue [active]
635013001370	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
635013001371	active site residue [active]
635013001372	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
635013001373	active site residue [active]
635013001374	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
635013001375	active site residue [active]
635013001376	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
635013001377	Ligand binding site; other site
635013001378	Putative Catalytic site; other site
635013001379	DXD motif; other site
635013001380	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013001381	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
635013001382	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
635013001383	NMT1-like family; Region: NMT1_2; cl15260
635013001384	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
635013001385	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
635013001386	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
635013001387	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
635013001388	Walker A/P-loop; other site
635013001389	ATP binding site [chemical binding]; other site
635013001390	Q-loop/lid; other site
635013001391	ABC transporter signature motif; other site
635013001392	Walker B; other site
635013001393	D-loop; other site
635013001394	H-loop/switch region; other site
635013001395	Transcriptional regulator [Transcription]; Region: LysR; COG0583
635013001396	Helix-turn-helix domains; Region: HTH; cl00088
635013001397	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
635013001398	putative dimerization interface [polypeptide binding]; other site
635013001399	putative inner membrane protein; Provisional; Region: PRK11099
635013001400	Sulphur transport; Region: Sulf_transp; cl01018
635013001401	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
635013001402	CPxP  motif; other site
635013001403	putative inner membrane protein; Provisional; Region: PRK11099
635013001404	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
635013001405	Transcriptional regulator [Transcription]; Region: LysR; COG0583
635013001406	Helix-turn-helix domains; Region: HTH; cl00088
635013001407	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
635013001408	putative dimerization interface [polypeptide binding]; other site
635013001409	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
635013001410	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013001411	dimerization interface [polypeptide binding]; other site
635013001412	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
635013001413	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
635013001414	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
635013001415	anti sigma factor interaction site; other site
635013001416	regulatory phosphorylation site [posttranslational modification]; other site
635013001417	Protein of unknown function (DUF342); Region: DUF342; pfam03961
635013001418	Protein of unknown function (DUF342); Region: DUF342; pfam03961
635013001419	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
635013001420	GAF domain; Region: GAF; cl15785
635013001421	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013001422	Zn2+ binding site [ion binding]; other site
635013001423	Mg2+ binding site [ion binding]; other site
635013001424	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
635013001425	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
635013001426	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013001427	PAS domain S-box; Region: sensory_box; TIGR00229
635013001428	Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331
635013001429	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
635013001430	Protein of unknown function, DUF606; Region: DUF606; cl01273
635013001431	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
635013001432	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
635013001433	active site
635013001434	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
635013001435	Helix-turn-helix domains; Region: HTH; cl00088
635013001436	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013001437	Major Facilitator Superfamily; Region: MFS_1; pfam07690
635013001438	putative substrate translocation pore; other site
635013001439	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013001440	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013001441	H+ Antiporter protein; Region: 2A0121; TIGR00900
635013001442	putative substrate translocation pore; other site
635013001443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013001444	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
635013001445	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
635013001446	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
635013001447	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
635013001448	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
635013001449	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
635013001450	Helix-turn-helix domains; Region: HTH; cl00088
635013001451	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
635013001452	putative dimerization interface [polypeptide binding]; other site
635013001453	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
635013001454	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
635013001455	PemK-like protein; Region: PemK; cl00995
635013001456	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
635013001457	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013001458	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
635013001459	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013001460	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
635013001461	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013001462	Family description; Region: UvrD_C_2; cl15862
635013001463	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013001464	CAAX protease self-immunity; Region: Abi; cl00558
635013001465	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
635013001466	Helix-turn-helix domains; Region: HTH; cl00088
635013001467	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
635013001468	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
635013001469	DNA binding residues [nucleotide binding]
635013001470	dimerization interface [polypeptide binding]; other site
635013001471	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
635013001472	FAD binding domain; Region: FAD_binding_4; pfam01565
635013001473	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
635013001474	Cysteine-rich domain; Region: CCG; pfam02754
635013001475	Cysteine-rich domain; Region: CCG; pfam02754
635013001476	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013001477	B12 binding site [chemical binding]; other site
635013001478	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
635013001479	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013001480	FeS/SAM binding site; other site
635013001481	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013001482	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
635013001483	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013001484	FeS/SAM binding site; other site
635013001485	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
635013001486	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013001487	S-adenosylmethionine binding site [chemical binding]; other site
635013001488	Predicted metal-binding protein (DUF2284); Region: DUF2284; cl02248
635013001489	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
635013001490	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
635013001491	putative dimer interface [polypeptide binding]; other site
635013001492	active site pocket [active]
635013001493	putative cataytic base [active]
635013001494	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
635013001495	ThiC family; Region: ThiC; cl08031
635013001496	ThiC family; Region: ThiC; cl08031
635013001497	Sodium:solute symporter family; Region: SSF; cl00456
635013001498	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
635013001499	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
635013001500	DNA binding residues [nucleotide binding]
635013001501	Peptidase family M48; Region: Peptidase_M48; cl12018
635013001502	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
635013001503	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
635013001504	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
635013001505	DNA binding residues [nucleotide binding]
635013001506	dimerization interface [polypeptide binding]; other site
635013001507	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
635013001508	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
635013001509	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
635013001510	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013001511	Walker A motif; other site
635013001512	ATP binding site [chemical binding]; other site
635013001513	Walker B motif; other site
635013001514	arginine finger; other site
635013001515	Integrase core domain; Region: rve; cl01316
635013001516	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
635013001517	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
635013001518	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
635013001519	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
635013001520	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
635013001521	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
635013001522	DNA binding residues [nucleotide binding]
635013001523	dimerization interface [polypeptide binding]; other site
635013001524	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
635013001525	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
635013001526	active site
635013001527	catalytic triad [active]
635013001528	Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529
635013001529	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
635013001530	translocation protein TolB; Provisional; Region: tolB; PRK05137
635013001531	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
635013001532	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
635013001533	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
635013001534	catalytic residues [active]
635013001535	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
635013001536	active site
635013001537	NTP binding site [chemical binding]; other site
635013001538	metal binding triad [ion binding]; metal-binding site
635013001539	antibiotic binding site [chemical binding]; other site
635013001540	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013001541	Major Facilitator Superfamily; Region: MFS_1; pfam07690
635013001542	putative substrate translocation pore; other site
635013001543	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
635013001544	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
635013001545	GGGtGRT protein; Region: GGGtGRT; pfam14057
635013001546	CrcB-like protein; Region: CRCB; cl09114
635013001547	CrcB-like protein; Region: CRCB; cl09114
635013001548	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
635013001549	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
635013001550	Dynamin family; Region: Dynamin_N; pfam00350
635013001551	G1 box; other site
635013001552	GTP/Mg2+ binding site [chemical binding]; other site
635013001553	G2 box; other site
635013001554	Switch I region; other site
635013001555	G3 box; other site
635013001556	Switch II region; other site
635013001557	G4 box; other site
635013001558	G5 box; other site
635013001559	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
635013001560	Uncharacterized conserved protein [Function unknown]; Region: COG4715
635013001561	SWIM zinc finger; Region: SWIM; cl15408
635013001562	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
635013001563	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
635013001564	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013001565	ATP binding site [chemical binding]; other site
635013001566	putative Mg++ binding site [ion binding]; other site
635013001567	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013001568	nucleotide binding region [chemical binding]; other site
635013001569	ATP-binding site [chemical binding]; other site
635013001570	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
635013001571	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
635013001572	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013001573	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
635013001574	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
635013001575	Reovirus sigma C capsid protein; Region: Reo_sigmaC; pfam04582
635013001576	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
635013001577	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
635013001578	active site
635013001579	NTP binding site [chemical binding]; other site
635013001580	metal binding triad [ion binding]; metal-binding site
635013001581	antibiotic binding site [chemical binding]; other site
635013001582	NMT1-like family; Region: NMT1_2; cl15260
635013001583	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
635013001584	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
635013001585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013001586	dimer interface [polypeptide binding]; other site
635013001587	conserved gate region; other site
635013001588	putative PBP binding loops; other site
635013001589	ABC-ATPase subunit interface; other site
635013001590	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
635013001591	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
635013001592	Walker A/P-loop; other site
635013001593	ATP binding site [chemical binding]; other site
635013001594	Q-loop/lid; other site
635013001595	ABC transporter signature motif; other site
635013001596	Walker B; other site
635013001597	D-loop; other site
635013001598	H-loop/switch region; other site
635013001599	Arginase family; Region: Arginase; cl00306
635013001600	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
635013001601	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
635013001602	alpha-gamma subunit interface [polypeptide binding]; other site
635013001603	beta-gamma subunit interface [polypeptide binding]; other site
635013001604	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
635013001605	gamma-beta subunit interface [polypeptide binding]; other site
635013001606	alpha-beta subunit interface [polypeptide binding]; other site
635013001607	urease subunit alpha; Reviewed; Region: ureC; PRK13207
635013001608	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
635013001609	subunit interactions [polypeptide binding]; other site
635013001610	active site
635013001611	flap region; other site
635013001612	urease accessory protein UreE; Provisional; Region: ureE; PRK13261
635013001613	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
635013001614	dimer interface [polypeptide binding]; other site
635013001615	catalytic residues [active]
635013001616	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
635013001617	UreF; Region: UreF; pfam01730
635013001618	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013001619	UreD urease accessory protein; Region: UreD; cl00530
635013001620	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
635013001621	Acetokinase family; Region: Acetate_kinase; cl01029
635013001622	propionate/acetate kinase; Provisional; Region: PRK12379
635013001623	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
635013001624	Sensory domain found in PocR; Region: PocR; pfam10114
635013001625	Histidine kinase; Region: His_kinase; pfam06580
635013001626	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013001627	ATP binding site [chemical binding]; other site
635013001628	Mg2+ binding site [ion binding]; other site
635013001629	G-X-G motif; other site
635013001630	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013001631	Response regulator receiver domain; Region: Response_reg; pfam00072
635013001632	active site
635013001633	phosphorylation site [posttranslational modification]
635013001634	intermolecular recognition site; other site
635013001635	dimerization interface [polypeptide binding]; other site
635013001636	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
635013001637	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
635013001638	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
635013001639	Hexamer interface [polypeptide binding]; other site
635013001640	Putative hexagonal pore residue; other site
635013001641	propanediol utilization protein PduB; Provisional; Region: PRK15415
635013001642	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
635013001643	putative hexamer interface [polypeptide binding]; other site
635013001644	putative hexagonal pore; other site
635013001645	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
635013001646	putative hexamer interface [polypeptide binding]; other site
635013001647	putative hexagonal pore; other site
635013001648	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
635013001649	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
635013001650	alpha-beta subunit interface [polypeptide binding]; other site
635013001651	alpha-gamma subunit interface [polypeptide binding]; other site
635013001652	active site
635013001653	substrate and K+ binding site; other site
635013001654	K+ binding site [ion binding]; other site
635013001655	cobalamin binding site [chemical binding]; other site
635013001656	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
635013001657	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
635013001658	Dehydratase small subunit; Region: Dehydratase_SU; cl02055
635013001659	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
635013001660	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
635013001661	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
635013001662	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
635013001663	Hexamer interface [polypeptide binding]; other site
635013001664	Hexagonal pore residue; other site
635013001665	1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059
635013001666	Hexamer interface [polypeptide binding]; other site
635013001667	Putative hexagonal pore residue; other site
635013001668	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
635013001669	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013001670	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013001671	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
635013001672	Cell division protein FtsA; Region: FtsA; cl11496
635013001673	Cell division protein FtsA; Region: FtsA; cl11496
635013001674	Flavoprotein; Region: Flavoprotein; cl08021
635013001675	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
635013001676	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
635013001677	Hexamer/Pentamer interface [polypeptide binding]; other site
635013001678	central pore; other site
635013001679	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
635013001680	Domain of unknown function (DUF336); Region: DUF336; cl01249
635013001681	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
635013001682	putative catalytic cysteine [active]
635013001683	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
635013001684	SLBB domain; Region: SLBB; pfam10531
635013001685	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
635013001686	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
635013001687	ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526
635013001688	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
635013001689	putative hexamer interface [polypeptide binding]; other site
635013001690	putative hexagonal pore; other site
635013001691	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
635013001692	Hexamer interface [polypeptide binding]; other site
635013001693	Hexagonal pore residue; other site
635013001694	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
635013001695	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
635013001696	dimer interface [polypeptide binding]; other site
635013001697	active site
635013001698	metal binding site [ion binding]; metal-binding site
635013001699	LrgA family; Region: LrgA; cl00608
635013001700	LrgB-like family; Region: LrgB; cl00596
635013001701	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
635013001702	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
635013001703	ligand binding site [chemical binding]; other site
635013001704	flexible hinge region; other site
635013001705	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
635013001706	putative switch regulator; other site
635013001707	non-specific DNA interactions [nucleotide binding]; other site
635013001708	DNA binding site [nucleotide binding]
635013001709	sequence specific DNA binding site [nucleotide binding]; other site
635013001710	putative cAMP binding site [chemical binding]; other site
635013001711	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
635013001712	histidinol phosphate phosphatase, HisJ family; Region: hisJ_fam; TIGR01856
635013001713	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
635013001714	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
635013001715	Walker A motif; other site
635013001716	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
635013001717	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
635013001718	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013001719	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013001720	putative peptidoglycan binding site; other site
635013001721	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013001722	putative peptidoglycan binding site; other site
635013001723	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013001724	putative peptidoglycan binding site; other site
635013001725	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
635013001726	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
635013001727	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
635013001728	protein binding site [polypeptide binding]; other site
635013001729	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
635013001730	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013001731	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013001732	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
635013001733	FOG: CBS domain [General function prediction only]; Region: COG0517
635013001734	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
635013001735	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
635013001736	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013001737	GAF domain; Region: GAF; cl15785
635013001738	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
635013001739	Histidine kinase; Region: His_kinase; pfam06580
635013001740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013001741	ATP binding site [chemical binding]; other site
635013001742	Mg2+ binding site [ion binding]; other site
635013001743	G-X-G motif; other site
635013001744	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
635013001745	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013001746	active site
635013001747	phosphorylation site [posttranslational modification]
635013001748	intermolecular recognition site; other site
635013001749	dimerization interface [polypeptide binding]; other site
635013001750	LytTr DNA-binding domain; Region: LytTR; cl04498
635013001751	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
635013001752	putative CheA interaction surface; other site
635013001753	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
635013001754	putative carbohydrate kinase; Provisional; Region: PRK10565
635013001755	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
635013001756	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
635013001757	putative substrate binding site [chemical binding]; other site
635013001758	putative ATP binding site [chemical binding]; other site
635013001759	FOG: CBS domain [General function prediction only]; Region: COG0517
635013001760	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
635013001761	alanine racemase; Reviewed; Region: alr; PRK00053
635013001762	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
635013001763	active site
635013001764	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
635013001765	dimer interface [polypeptide binding]; other site
635013001766	substrate binding site [chemical binding]; other site
635013001767	catalytic residues [active]
635013001768	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
635013001769	Protein of unknown function (DUF342); Region: DUF342; pfam03961
635013001770	Protein of unknown function (DUF342); Region: DUF342; pfam03961
635013001771	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
635013001772	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013001773	active site
635013001774	phosphorylation site [posttranslational modification]
635013001775	intermolecular recognition site; other site
635013001776	dimerization interface [polypeptide binding]; other site
635013001777	ANTAR domain; Region: ANTAR; cl04297
635013001778	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
635013001779	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
635013001780	active site
635013001781	FMN binding site [chemical binding]; other site
635013001782	substrate binding site [chemical binding]; other site
635013001783	3Fe-4S cluster binding site [ion binding]; other site
635013001784	hypothetical protein; Region: PHA00736
635013001785	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
635013001786	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013001787	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013001788	dimer interface [polypeptide binding]; other site
635013001789	putative CheW interface [polypeptide binding]; other site
635013001790	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
635013001791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013001792	active site
635013001793	phosphorylation site [posttranslational modification]
635013001794	intermolecular recognition site; other site
635013001795	dimerization interface [polypeptide binding]; other site
635013001796	ANTAR domain; Region: ANTAR; cl04297
635013001797	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
635013001798	octamerization interface [polypeptide binding]; other site
635013001799	diferric-oxygen binding site [ion binding]; other site
635013001800	Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl15774
635013001801	octamerization interface [polypeptide binding]; other site
635013001802	diferric-oxygen binding site [ion binding]; other site
635013001803	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
635013001804	active site
635013001805	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
635013001806	dimer interface [polypeptide binding]; other site
635013001807	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
635013001808	Ligand Binding Site [chemical binding]; other site
635013001809	Molecular Tunnel; other site
635013001810	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013001811	non-specific DNA binding site [nucleotide binding]; other site
635013001812	salt bridge; other site
635013001813	sequence-specific DNA binding site [nucleotide binding]; other site
635013001814	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
635013001815	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
635013001816	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
635013001817	[4Fe-4S] binding site [ion binding]; other site
635013001818	molybdopterin cofactor binding site; other site
635013001819	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
635013001820	molybdopterin cofactor binding site; other site
635013001821	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
635013001822	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
635013001823	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
635013001824	FAD binding pocket [chemical binding]; other site
635013001825	FAD binding motif [chemical binding]; other site
635013001826	phosphate binding motif [ion binding]; other site
635013001827	beta-alpha-beta structure motif; other site
635013001828	NAD binding pocket [chemical binding]; other site
635013001829	Iron coordination center [ion binding]; other site
635013001830	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
635013001831	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
635013001832	HicB family; Region: HicB; pfam05534
635013001833	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
635013001834	Fic family protein [Function unknown]; Region: COG3177
635013001835	Fic/DOC family; Region: Fic; cl00960
635013001836	YmaF family; Region: YmaF; pfam12788
635013001837	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
635013001838	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
635013001839	Nucleotide-binding sites [chemical binding]; other site
635013001840	Walker A motif; other site
635013001841	Switch I region of nucleotide binding site; other site
635013001842	Fe4S4 binding sites [ion binding]; other site
635013001843	Switch II region of nucleotide binding site; other site
635013001844	Nitrogen regulatory protein P-II; Region: P-II; cl00412
635013001845	Nitrogen regulatory protein P-II; Region: P-II; smart00938
635013001846	Nitrogen regulatory protein P-II; Region: P-II; cl00412
635013001847	Nitrogen regulatory protein P-II; Region: P-II; smart00938
635013001848	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
635013001849	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
635013001850	MoFe protein alpha/beta subunit interactions; other site
635013001851	Alpha subunit P cluster binding residues; other site
635013001852	FeMoco binding residues [chemical binding]; other site
635013001853	MoFe protein alpha subunit/Fe protein contacts; other site
635013001854	MoFe protein dimer/ dimer interactions; other site
635013001855	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
635013001856	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
635013001857	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
635013001858	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
635013001859	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
635013001860	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
635013001861	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
635013001862	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013001863	FeS/SAM binding site; other site
635013001864	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
635013001865	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
635013001866	dimer interface [polypeptide binding]; other site
635013001867	[2Fe-2S] cluster binding site [ion binding]; other site
635013001868	Iron only nitrogenase protein AnfO (AnfO_nitrog); Region: AnfO_nitrog; pfam09582
635013001869	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
635013001870	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
635013001871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013001872	dimer interface [polypeptide binding]; other site
635013001873	conserved gate region; other site
635013001874	putative PBP binding loops; other site
635013001875	ABC-ATPase subunit interface; other site
635013001876	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013001877	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
635013001878	Walker A/P-loop; other site
635013001879	ATP binding site [chemical binding]; other site
635013001880	Q-loop/lid; other site
635013001881	ABC transporter signature motif; other site
635013001882	Walker B; other site
635013001883	D-loop; other site
635013001884	H-loop/switch region; other site
635013001885	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
635013001886	active site
635013001887	catalytic residues [active]
635013001888	metal binding site [ion binding]; metal-binding site
635013001889	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
635013001890	Nitrogen regulatory protein P-II; Region: P-II; cl00412
635013001891	Nitrogen regulatory protein P-II; Region: P-II; smart00938
635013001892	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
635013001893	Nitrogen regulatory protein P-II; Region: P-II; cl00412
635013001894	Nitrogen regulatory protein P-II; Region: P-II; smart00938
635013001895	Nitrogen regulatory protein P-II; Region: P-II; cl00412
635013001896	Nitrogen regulatory protein P-II; Region: P-II; smart00938
635013001897	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
635013001898	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013001899	active site
635013001900	phosphorylation site [posttranslational modification]
635013001901	intermolecular recognition site; other site
635013001902	dimerization interface [polypeptide binding]; other site
635013001903	ANTAR domain; Region: ANTAR; cl04297
635013001904	glutamine synthetase, type I; Region: GlnA; TIGR00653
635013001905	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
635013001906	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
635013001907	glutamine synthetase, type I; Region: GlnA; TIGR00653
635013001908	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
635013001909	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
635013001910	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
635013001911	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
635013001912	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
635013001913	putative active site [active]
635013001914	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
635013001915	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
635013001916	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
635013001917	active site
635013001918	FMN binding site [chemical binding]; other site
635013001919	substrate binding site [chemical binding]; other site
635013001920	3Fe-4S cluster binding site [ion binding]; other site
635013001921	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
635013001922	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
635013001923	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013001924	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
635013001925	putative subunit interface; other site
635013001926	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
635013001927	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
635013001928	PemK-like protein; Region: PemK; cl00995
635013001929	Peptidase C26; Region: Peptidase_C26; pfam07722
635013001930	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
635013001931	catalytic triad [active]
635013001932	Uncharacterized conserved protein [Function unknown]; Region: COG0327
635013001933	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
635013001934	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
635013001935	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
635013001936	active site
635013001937	Response regulator receiver domain; Region: Response_reg; pfam00072
635013001938	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013001939	active site
635013001940	phosphorylation site [posttranslational modification]
635013001941	intermolecular recognition site; other site
635013001942	dimerization interface [polypeptide binding]; other site
635013001943	HMP-P kinase/thiamin-monophosphate pyrophosphorylase; Region: PLN02898
635013001944	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
635013001945	dimer interface [polypeptide binding]; other site
635013001946	substrate binding site [chemical binding]; other site
635013001947	ATP binding site [chemical binding]; other site
635013001948	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
635013001949	thiamine phosphate binding site [chemical binding]; other site
635013001950	active site
635013001951	pyrophosphate binding site [ion binding]; other site
635013001952	ThiC family; Region: ThiC; cl08031
635013001953	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
635013001954	substrate binding site [chemical binding]; other site
635013001955	multimerization interface [polypeptide binding]; other site
635013001956	ATP binding site [chemical binding]; other site
635013001957	thiamine monophosphate kinase; Provisional; Region: PRK05731
635013001958	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
635013001959	ATP binding site [chemical binding]; other site
635013001960	dimerization interface [polypeptide binding]; other site
635013001961	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
635013001962	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
635013001963	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
635013001964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
635013001965	Coenzyme A binding pocket [chemical binding]; other site
635013001966	UGMP family protein; Validated; Region: PRK09604
635013001967	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
635013001968	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
635013001969	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
635013001970	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013001971	Radical SAM superfamily; Region: Radical_SAM; pfam04055
635013001972	FeS/SAM binding site; other site
635013001973	RIP metalloprotease RseP; Region: TIGR00054
635013001974	PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992
635013001975	Protein of unknown function (DUF512); Region: DUF512; pfam04459
635013001976	AMP-binding enzyme; Region: AMP-binding; cl15778
635013001977	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
635013001978	ACT domain-containing protein [General function prediction only]; Region: COG4747
635013001979	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
635013001980	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
635013001981	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360
635013001982	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
635013001983	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
635013001984	putative dimer interface [polypeptide binding]; other site
635013001985	[2Fe-2S] cluster binding site [ion binding]; other site
635013001986	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
635013001987	dimer interface [polypeptide binding]; other site
635013001988	[2Fe-2S] cluster binding site [ion binding]; other site
635013001989	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
635013001990	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
635013001991	SLBB domain; Region: SLBB; pfam10531
635013001992	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
635013001993	4Fe-4S binding domain; Region: Fer4; cl02805
635013001994	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013001995	catalytic loop [active]
635013001996	iron binding site [ion binding]; other site
635013001997	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
635013001998	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
635013001999	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
635013002000	4Fe-4S binding domain; Region: Fer4; cl02805
635013002001	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013002002	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013002003	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013002004	catalytic loop [active]
635013002005	iron binding site [ion binding]; other site
635013002006	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
635013002007	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
635013002008	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013002009	4Fe-4S binding domain; Region: Fer4; cl02805
635013002010	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013002011	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013002012	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013002013	molybdopterin cofactor binding site; other site
635013002014	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
635013002015	molybdopterin cofactor binding site; other site
635013002016	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013002017	Zn2+ binding site [ion binding]; other site
635013002018	Mg2+ binding site [ion binding]; other site
635013002019	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013002020	Zn2+ binding site [ion binding]; other site
635013002021	Mg2+ binding site [ion binding]; other site
635013002022	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
635013002023	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
635013002024	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013002025	Zn2+ binding site [ion binding]; other site
635013002026	Mg2+ binding site [ion binding]; other site
635013002027	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
635013002028	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
635013002029	NAD binding site [chemical binding]; other site
635013002030	dimer interface [polypeptide binding]; other site
635013002031	substrate binding site [chemical binding]; other site
635013002032	tetramer (dimer of dimers) interface [polypeptide binding]; other site
635013002033	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
635013002034	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
635013002035	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
635013002036	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
635013002037	catalytic residue [active]
635013002038	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
635013002039	dimerization interface [polypeptide binding]; other site
635013002040	putative ATP binding site [chemical binding]; other site
635013002041	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
635013002042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
635013002043	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
635013002044	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
635013002045	putative active site [active]
635013002046	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002047	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
635013002048	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
635013002049	dimer interface [polypeptide binding]; other site
635013002050	putative functional site; other site
635013002051	putative MPT binding site; other site
635013002052	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
635013002053	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
635013002054	dimer interface [polypeptide binding]; other site
635013002055	putative functional site; other site
635013002056	putative MPT binding site; other site
635013002057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
635013002058	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
635013002059	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013002060	FeS/SAM binding site; other site
635013002061	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
635013002062	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
635013002063	trimer interface [polypeptide binding]; other site
635013002064	dimer interface [polypeptide binding]; other site
635013002065	putative active site [active]
635013002066	MOSC domain; Region: MOSC; pfam03473
635013002067	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
635013002068	MPT binding site; other site
635013002069	trimer interface [polypeptide binding]; other site
635013002070	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013002071	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013002072	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
635013002073	Predicted Fe-S protein [General function prediction only]; Region: COG2000
635013002074	Putative Fe-S cluster; Region: FeS; pfam04060
635013002075	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
635013002076	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013002077	Walker A motif; other site
635013002078	ATP binding site [chemical binding]; other site
635013002079	Walker B motif; other site
635013002080	arginine finger; other site
635013002081	Helix-turn-helix domains; Region: HTH; cl00088
635013002082	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
635013002083	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
635013002084	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
635013002085	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
635013002086	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
635013002087	putative substrate-binding site; other site
635013002088	nickel binding site [ion binding]; other site
635013002089	hydrogenase 2 protein HybA; Provisional; Region: PRK10882
635013002090	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
635013002091	4Fe-4S binding domain; Region: Fer4; cl02805
635013002092	Polysulphide reductase, NrfD; Region: NrfD; cl01295
635013002093	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013002094	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013002095	molybdopterin cofactor binding site; other site
635013002096	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013002097	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
635013002098	molybdopterin cofactor binding site; other site
635013002099	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
635013002100	4Fe-4S binding domain; Region: Fer4; cl02805
635013002101	Polysulphide reductase, NrfD; Region: NrfD; cl01295
635013002102	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
635013002103	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
635013002104	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
635013002105	oligomerisation interface [polypeptide binding]; other site
635013002106	mobile loop; other site
635013002107	roof hairpin; other site
635013002108	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
635013002109	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
635013002110	ring oligomerisation interface [polypeptide binding]; other site
635013002111	ATP/Mg binding site [chemical binding]; other site
635013002112	stacking interactions; other site
635013002113	hinge regions; other site
635013002114	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
635013002115	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
635013002116	dimer interface [polypeptide binding]; other site
635013002117	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013002118	catalytic residue [active]
635013002119	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
635013002120	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013002121	Zn2+ binding site [ion binding]; other site
635013002122	Mg2+ binding site [ion binding]; other site
635013002123	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
635013002124	S-layer homology domain; Region: SLH; pfam00395
635013002125	S-layer homology domain; Region: SLH; pfam00395
635013002126	S-layer homology domain; Region: SLH; pfam00395
635013002127	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013002128	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
635013002129	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
635013002130	DNA binding site [nucleotide binding]
635013002131	active site
635013002132	MoxR-like ATPases [General function prediction only]; Region: COG0714
635013002133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013002134	Walker A motif; other site
635013002135	ATP binding site [chemical binding]; other site
635013002136	Walker B motif; other site
635013002137	arginine finger; other site
635013002138	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
635013002139	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
635013002140	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
635013002141	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
635013002142	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013002143	active site
635013002144	GMP synthase; Reviewed; Region: guaA; PRK00074
635013002145	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
635013002146	AMP/PPi binding site [chemical binding]; other site
635013002147	candidate oxyanion hole; other site
635013002148	catalytic triad [active]
635013002149	potential glutamine specificity residues [chemical binding]; other site
635013002150	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
635013002151	ATP Binding subdomain [chemical binding]; other site
635013002152	Ligand Binding sites [chemical binding]; other site
635013002153	Dimerization subdomain; other site
635013002154	B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013
635013002155	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013002156	B12 binding site [chemical binding]; other site
635013002157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013002158	FeS/SAM binding site; other site
635013002159	Helix-turn-helix domains; Region: HTH; cl00088
635013002160	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
635013002161	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013002162	dimer interface [polypeptide binding]; other site
635013002163	conserved gate region; other site
635013002164	putative PBP binding loops; other site
635013002165	ABC-ATPase subunit interface; other site
635013002166	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
635013002167	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002168	Walker A/P-loop; other site
635013002169	ATP binding site [chemical binding]; other site
635013002170	Q-loop/lid; other site
635013002171	ABC transporter signature motif; other site
635013002172	Walker B; other site
635013002173	D-loop; other site
635013002174	H-loop/switch region; other site
635013002175	TOBE domain; Region: TOBE_2; cl01440
635013002176	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
635013002177	Catalytic domain of Protein Kinases; Region: PKc; cd00180
635013002178	active site
635013002179	ATP binding site [chemical binding]; other site
635013002180	substrate binding site [chemical binding]; other site
635013002181	activation loop (A-loop); other site
635013002182	AAA domain; Region: AAA_31; pfam13614
635013002183	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
635013002184	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013002185	dimer interface [polypeptide binding]; other site
635013002186	phosphorylation site [posttranslational modification]
635013002187	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013002188	ATP binding site [chemical binding]; other site
635013002189	Mg2+ binding site [ion binding]; other site
635013002190	G-X-G motif; other site
635013002191	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
635013002192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013002193	active site
635013002194	phosphorylation site [posttranslational modification]
635013002195	intermolecular recognition site; other site
635013002196	dimerization interface [polypeptide binding]; other site
635013002197	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
635013002198	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013002199	Walker A/P-loop; other site
635013002200	ATP binding site [chemical binding]; other site
635013002201	Q-loop/lid; other site
635013002202	ABC transporter signature motif; other site
635013002203	Walker B; other site
635013002204	D-loop; other site
635013002205	H-loop/switch region; other site
635013002206	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013002207	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
635013002208	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013002209	Walker A/P-loop; other site
635013002210	ATP binding site [chemical binding]; other site
635013002211	Q-loop/lid; other site
635013002212	ABC transporter signature motif; other site
635013002213	Walker B; other site
635013002214	D-loop; other site
635013002215	H-loop/switch region; other site
635013002216	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013002217	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
635013002218	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
635013002219	peptide binding site [polypeptide binding]; other site
635013002220	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
635013002221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013002222	dimer interface [polypeptide binding]; other site
635013002223	conserved gate region; other site
635013002224	putative PBP binding loops; other site
635013002225	ABC-ATPase subunit interface; other site
635013002226	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
635013002227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013002228	dimer interface [polypeptide binding]; other site
635013002229	conserved gate region; other site
635013002230	putative PBP binding loops; other site
635013002231	ABC-ATPase subunit interface; other site
635013002232	Uncharacterized conserved protein [Function unknown]; Region: COG1572
635013002233	Fibronectin type III-like domain; Region: Fn3-like; cl15273
635013002234	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013002235	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013002236	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013002237	SAF domain; Region: SAF; cl00555
635013002238	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
635013002239	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
635013002240	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002241	Walker A motif; other site
635013002242	ATP binding site [chemical binding]; other site
635013002243	Walker B motif; other site
635013002244	hydrolase; Region: PLN02511
635013002245	PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386
635013002246	active site
635013002247	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
635013002248	Helix-turn-helix domains; Region: HTH; cl00088
635013002249	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
635013002250	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
635013002251	Walker A/P-loop; other site
635013002252	ATP binding site [chemical binding]; other site
635013002253	Q-loop/lid; other site
635013002254	ABC transporter signature motif; other site
635013002255	Walker B; other site
635013002256	D-loop; other site
635013002257	H-loop/switch region; other site
635013002258	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
635013002259	FtsX-like permease family; Region: FtsX; cl15850
635013002260	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
635013002261	FtsX-like permease family; Region: FtsX; cl15850
635013002262	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
635013002263	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013002264	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013002265	Transcriptional regulator [Transcription]; Region: LysR; COG0583
635013002266	Helix-turn-helix domains; Region: HTH; cl00088
635013002267	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
635013002268	dimerization interface [polypeptide binding]; other site
635013002269	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
635013002270	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
635013002271	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
635013002272	dimerization interface [polypeptide binding]; other site
635013002273	ATP binding site [chemical binding]; other site
635013002274	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
635013002275	dimerization interface [polypeptide binding]; other site
635013002276	ATP binding site [chemical binding]; other site
635013002277	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
635013002278	putative active site [active]
635013002279	catalytic triad [active]
635013002280	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
635013002281	AIR carboxylase; Region: AIRC; cl00310
635013002282	adenylosuccinate lyase; Provisional; Region: PRK07492
635013002283	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
635013002284	tetramer interface [polypeptide binding]; other site
635013002285	active site
635013002286	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
635013002287	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
635013002288	ATP binding site [chemical binding]; other site
635013002289	active site
635013002290	substrate binding site [chemical binding]; other site
635013002291	amidophosphoribosyltransferase; Provisional; Region: PRK05793
635013002292	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
635013002293	active site
635013002294	tetramer interface [polypeptide binding]; other site
635013002295	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013002296	active site
635013002297	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
635013002298	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
635013002299	dimerization interface [polypeptide binding]; other site
635013002300	putative ATP binding site [chemical binding]; other site
635013002301	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
635013002302	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
635013002303	active site
635013002304	substrate binding site [chemical binding]; other site
635013002305	cosubstrate binding site; other site
635013002306	catalytic site [active]
635013002307	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
635013002308	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
635013002309	purine monophosphate binding site [chemical binding]; other site
635013002310	dimer interface [polypeptide binding]; other site
635013002311	putative catalytic residues [active]
635013002312	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
635013002313	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
635013002314	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
635013002315	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
635013002316	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013002317	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
635013002318	Helix-turn-helix domains; Region: HTH; cl00088
635013002319	sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053
635013002320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013002321	ATP binding site [chemical binding]; other site
635013002322	Mg2+ binding site [ion binding]; other site
635013002323	G-X-G motif; other site
635013002324	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292
635013002325	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
635013002326	dimer interface [polypeptide binding]; other site
635013002327	motif 1; other site
635013002328	active site
635013002329	motif 2; other site
635013002330	motif 3; other site
635013002331	ATP phosphoribosyltransferase; Region: HisG; cl15266
635013002332	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
635013002333	histidinol dehydrogenase; Region: hisD; TIGR00069
635013002334	NAD binding site [chemical binding]; other site
635013002335	dimerization interface [polypeptide binding]; other site
635013002336	product binding site; other site
635013002337	substrate binding site [chemical binding]; other site
635013002338	zinc binding site [ion binding]; other site
635013002339	catalytic residues [active]
635013002340	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
635013002341	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
635013002342	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013002343	homodimer interface [polypeptide binding]; other site
635013002344	catalytic residue [active]
635013002345	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
635013002346	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
635013002347	4-fold oligomerization interface [polypeptide binding]; other site
635013002348	putative active site pocket [active]
635013002349	metal binding residues [ion binding]; metal-binding site
635013002350	3-fold/trimer interface [polypeptide binding]; other site
635013002351	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
635013002352	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
635013002353	putative active site [active]
635013002354	oxyanion strand; other site
635013002355	catalytic triad [active]
635013002356	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
635013002357	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
635013002358	catalytic residues [active]
635013002359	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
635013002360	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
635013002361	substrate binding site [chemical binding]; other site
635013002362	glutamase interaction surface [polypeptide binding]; other site
635013002363	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
635013002364	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
635013002365	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
635013002366	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
635013002367	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
635013002368	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013002369	dimerization interface [polypeptide binding]; other site
635013002370	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013002371	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013002372	dimer interface [polypeptide binding]; other site
635013002373	putative CheW interface [polypeptide binding]; other site
635013002374	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
635013002375	dinuclear metal binding motif [ion binding]; other site
635013002376	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
635013002377	Protein of unknown function (DUF1634); Region: DUF1634; cl01741
635013002378	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
635013002379	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002380	Family description; Region: UvrD_C_2; cl15862
635013002381	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
635013002382	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
635013002383	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
635013002384	nucleotide binding pocket [chemical binding]; other site
635013002385	K-X-D-G motif; other site
635013002386	catalytic site [active]
635013002387	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
635013002388	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
635013002389	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
635013002390	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
635013002391	Dimer interface [polypeptide binding]; other site
635013002392	BRCT sequence motif; other site
635013002393	Rrf2 family protein; Region: rrf2_super; TIGR00738
635013002394	Helix-turn-helix domains; Region: HTH; cl00088
635013002395	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
635013002396	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
635013002397	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
635013002398	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
635013002399	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
635013002400	diiron binding motif [ion binding]; other site
635013002401	putative alcohol dehydrogenase; Provisional; Region: PRK09860
635013002402	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
635013002403	dimer interface [polypeptide binding]; other site
635013002404	active site
635013002405	metal binding site [ion binding]; metal-binding site
635013002406	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
635013002407	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
635013002408	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
635013002409	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
635013002410	active site
635013002411	catalytic triad [active]
635013002412	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
635013002413	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
635013002414	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
635013002415	Protein of unknown function (DUF523); Region: DUF523; cl00733
635013002416	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
635013002417	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
635013002418	substrate binding pocket [chemical binding]; other site
635013002419	membrane-bound complex binding site; other site
635013002420	hinge residues; other site
635013002421	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013002422	dimer interface [polypeptide binding]; other site
635013002423	conserved gate region; other site
635013002424	putative PBP binding loops; other site
635013002425	ABC-ATPase subunit interface; other site
635013002426	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013002427	Fibronectin type III-like domain; Region: Fn3-like; cl15273
635013002428	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
635013002429	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
635013002430	Amidase; Region: Amidase; cl11426
635013002431	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
635013002432	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
635013002433	GatB domain; Region: GatB_Yqey; cl11497
635013002434	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
635013002435	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
635013002436	active site
635013002437	catalytic residues [active]
635013002438	metal binding site [ion binding]; metal-binding site
635013002439	isocitrate dehydrogenase; Validated; Region: PRK06451
635013002440	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
635013002441	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
635013002442	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013002443	active site
635013002444	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
635013002445	TM-ABC transporter signature motif; other site
635013002446	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
635013002447	TM-ABC transporter signature motif; other site
635013002448	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
635013002449	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
635013002450	Walker A/P-loop; other site
635013002451	ATP binding site [chemical binding]; other site
635013002452	Q-loop/lid; other site
635013002453	ABC transporter signature motif; other site
635013002454	Walker B; other site
635013002455	D-loop; other site
635013002456	H-loop/switch region; other site
635013002457	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
635013002458	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
635013002459	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
635013002460	putative ligand binding site [chemical binding]; other site
635013002461	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
635013002462	Carbohydrate binding domain (family 25); Region: CBM_25; cl04060
635013002463	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
635013002464	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
635013002465	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
635013002466	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
635013002467	active site
635013002468	Substrate binding site; other site
635013002469	Mg++ binding site; other site
635013002470	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
635013002471	Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356
635013002472	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
635013002473	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
635013002474	active site
635013002475	substrate binding site [chemical binding]; other site
635013002476	metal binding site [ion binding]; metal-binding site
635013002477	Uncharacterized conserved protein [Function unknown]; Region: COG1543
635013002478	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
635013002479	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
635013002480	CAAX protease self-immunity; Region: Abi; cl00558
635013002481	TRAM domain; Region: TRAM; cl01282
635013002482	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
635013002483	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
635013002484	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
635013002485	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013002486	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013002487	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
635013002488	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013002489	non-specific DNA binding site [nucleotide binding]; other site
635013002490	salt bridge; other site
635013002491	sequence-specific DNA binding site [nucleotide binding]; other site
635013002492	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1223
635013002493	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013002494	Walker A motif; other site
635013002495	ATP binding site [chemical binding]; other site
635013002496	Walker B motif; other site
635013002497	arginine finger; other site
635013002498	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
635013002499	active site
635013002500	catalytic triad [active]
635013002501	HsdM N-terminal domain; Region: HsdM_N; pfam12161
635013002502	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
635013002503	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013002504	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
635013002505	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
635013002506	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
635013002507	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
635013002508	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
635013002509	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002510	Domain of unknown function (DUF3387); Region: DUF3387; pfam11867
635013002511	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
635013002512	putative active site [active]
635013002513	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013002514	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
635013002515	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
635013002516	NAD binding site [chemical binding]; other site
635013002517	substrate binding site [chemical binding]; other site
635013002518	homodimer interface [polypeptide binding]; other site
635013002519	active site
635013002520	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
635013002521	homodimer interface [polypeptide binding]; other site
635013002522	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
635013002523	active site pocket [active]
635013002524	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
635013002525	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
635013002526	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
635013002527	putative active site [active]
635013002528	catalytic site [active]
635013002529	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
635013002530	putative active site [active]
635013002531	catalytic site [active]
635013002532	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
635013002533	putative dimer interface [polypeptide binding]; other site
635013002534	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
635013002535	Ligand Binding Site [chemical binding]; other site
635013002536	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
635013002537	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
635013002538	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
635013002539	active site
635013002540	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
635013002541	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
635013002542	catalytic triad [active]
635013002543	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
635013002544	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
635013002545	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013002546	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013002547	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
635013002548	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013002549	putative substrate translocation pore; other site
635013002550	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013002551	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
635013002552	Helix-turn-helix domains; Region: HTH; cl00088
635013002553	AzlC protein; Region: AzlC; cl00570
635013002554	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
635013002555	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
635013002556	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
635013002557	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013002558	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
635013002559	active site
635013002560	ATP binding site [chemical binding]; other site
635013002561	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
635013002562	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002563	Walker A/P-loop; other site
635013002564	ATP binding site [chemical binding]; other site
635013002565	Q-loop/lid; other site
635013002566	ABC transporter signature motif; other site
635013002567	Walker B; other site
635013002568	D-loop; other site
635013002569	H-loop/switch region; other site
635013002570	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
635013002571	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
635013002572	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
635013002573	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
635013002574	HSP70 interaction site [polypeptide binding]; other site
635013002575	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
635013002576	substrate binding site [polypeptide binding]; other site
635013002577	dimer interface [polypeptide binding]; other site
635013002578	MerR HTH family regulatory protein; Region: MerR_2; pfam13591
635013002579	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
635013002580	Clp amino terminal domain; Region: Clp_N; pfam02861
635013002581	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013002582	Walker A motif; other site
635013002583	ATP binding site [chemical binding]; other site
635013002584	Walker B motif; other site
635013002585	arginine finger; other site
635013002586	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013002587	Walker A motif; other site
635013002588	ATP binding site [chemical binding]; other site
635013002589	Walker B motif; other site
635013002590	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
635013002591	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
635013002592	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
635013002593	catalytic residue [active]
635013002594	putative FPP diphosphate  binding site; other site
635013002595	putative FPP binding hydrophobic cleft; other site
635013002596	dimer interface [polypeptide binding]; other site
635013002597	putative IPP diphosphate binding site; other site
635013002598	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
635013002599	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013002600	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
635013002601	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
635013002602	active site residue [active]
635013002603	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
635013002604	Helix-turn-helix domains; Region: HTH; cl00088
635013002605	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
635013002606	Protein export membrane protein; Region: SecD_SecF; cl14618
635013002607	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
635013002608	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants, cyanobacteria; Region: Thr-synth_2; cd01560
635013002609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013002610	catalytic residue [active]
635013002611	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
635013002612	4Fe-4S binding domain; Region: Fer4; cl02805
635013002613	4Fe-4S binding domain; Region: Fer4; cl02805
635013002614	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
635013002615	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
635013002616	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
635013002617	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
635013002618	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013002619	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
635013002620	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
635013002621	FAD binding pocket [chemical binding]; other site
635013002622	FAD binding motif [chemical binding]; other site
635013002623	phosphate binding motif [ion binding]; other site
635013002624	beta-alpha-beta structure motif; other site
635013002625	NAD binding pocket [chemical binding]; other site
635013002626	Iron coordination center [ion binding]; other site
635013002627	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
635013002628	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013002629	catalytic loop [active]
635013002630	iron binding site [ion binding]; other site
635013002631	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
635013002632	4Fe-4S binding domain; Region: Fer4; cl02805
635013002633	4Fe-4S binding domain; Region: Fer4; cl02805
635013002634	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
635013002635	[4Fe-4S] binding site [ion binding]; other site
635013002636	molybdopterin cofactor binding site; other site
635013002637	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
635013002638	molybdopterin cofactor binding site; other site
635013002639	Helix-turn-helix domains; Region: HTH; cl00088
635013002640	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
635013002641	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
635013002642	putative dimerization interface [polypeptide binding]; other site
635013002643	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
635013002644	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
635013002645	DNA-binding site [nucleotide binding]; DNA binding site
635013002646	RNA-binding motif; other site
635013002647	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
635013002648	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
635013002649	Ligand Binding Site [chemical binding]; other site
635013002650	multicopper oxidase; Provisional; Region: PRK10965
635013002651	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
635013002652	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
635013002653	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
635013002654	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
635013002655	active site clefts [active]
635013002656	zinc binding site [ion binding]; other site
635013002657	dimer interface [polypeptide binding]; other site
635013002658	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
635013002659	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013002660	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013002661	DNA binding residues [nucleotide binding]
635013002662	Putative zinc-finger; Region: zf-HC2; cl15806
635013002663	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
635013002664	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
635013002665	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
635013002666	putative metal binding site; other site
635013002667	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
635013002668	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002669	binding surface
635013002670	TPR motif; other site
635013002671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002672	TPR motif; other site
635013002673	binding surface
635013002674	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
635013002675	putative metal binding site; other site
635013002676	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002677	binding surface
635013002678	TPR motif; other site
635013002679	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
635013002680	putative metal binding site; other site
635013002681	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002682	TPR motif; other site
635013002683	binding surface
635013002684	Tetratricopeptide repeat; Region: TPR_12; pfam13424
635013002685	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002686	binding surface
635013002687	TPR motif; other site
635013002688	TPR repeat; Region: TPR_11; pfam13414
635013002689	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
635013002690	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
635013002691	active site
635013002692	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013002693	S-adenosylmethionine binding site [chemical binding]; other site
635013002694	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
635013002695	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
635013002696	putative metal binding site; other site
635013002697	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002698	binding surface
635013002699	TPR motif; other site
635013002700	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
635013002701	putative metal binding site; other site
635013002702	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002703	binding surface
635013002704	TPR motif; other site
635013002705	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002706	binding surface
635013002707	TPR motif; other site
635013002708	DNA polymerase I; Provisional; Region: PRK05755
635013002709	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
635013002710	active site
635013002711	metal binding site 1 [ion binding]; metal-binding site
635013002712	putative 5' ssDNA interaction site; other site
635013002713	metal binding site 3; metal-binding site
635013002714	metal binding site 2 [ion binding]; metal-binding site
635013002715	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
635013002716	putative DNA binding site [nucleotide binding]; other site
635013002717	putative metal binding site [ion binding]; other site
635013002718	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
635013002719	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
635013002720	active site
635013002721	DNA binding site [nucleotide binding]
635013002722	catalytic site [active]
635013002723	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
635013002724	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
635013002725	DNA binding site [nucleotide binding]
635013002726	catalytic residue [active]
635013002727	H2TH interface [polypeptide binding]; other site
635013002728	putative catalytic residues [active]
635013002729	turnover-facilitating residue; other site
635013002730	intercalation triad [nucleotide binding]; other site
635013002731	8OG recognition residue [nucleotide binding]; other site
635013002732	putative reading head residues; other site
635013002733	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
635013002734	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
635013002735	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
635013002736	Domain of unknown function DUF; Region: DUF204; pfam02659
635013002737	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
635013002738	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
635013002739	CoA-binding site [chemical binding]; other site
635013002740	ATP-binding [chemical binding]; other site
635013002741	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
635013002742	N-acetyl-D-glucosamine binding site [chemical binding]; other site
635013002743	catalytic residue [active]
635013002744	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
635013002745	peptide binding site [polypeptide binding]; other site
635013002746	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
635013002747	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
635013002748	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013002749	dimer interface [polypeptide binding]; other site
635013002750	conserved gate region; other site
635013002751	putative PBP binding loops; other site
635013002752	ABC-ATPase subunit interface; other site
635013002753	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
635013002754	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013002755	dimer interface [polypeptide binding]; other site
635013002756	conserved gate region; other site
635013002757	putative PBP binding loops; other site
635013002758	ABC-ATPase subunit interface; other site
635013002759	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
635013002760	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013002761	Walker A/P-loop; other site
635013002762	ATP binding site [chemical binding]; other site
635013002763	Q-loop/lid; other site
635013002764	ABC transporter signature motif; other site
635013002765	Walker B; other site
635013002766	D-loop; other site
635013002767	H-loop/switch region; other site
635013002768	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013002769	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
635013002770	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013002771	Walker A/P-loop; other site
635013002772	ATP binding site [chemical binding]; other site
635013002773	Q-loop/lid; other site
635013002774	ABC transporter signature motif; other site
635013002775	Walker B; other site
635013002776	D-loop; other site
635013002777	H-loop/switch region; other site
635013002778	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013002779	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
635013002780	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
635013002781	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
635013002782	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013002783	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
635013002784	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
635013002785	MtaA_CmuA_like family. MtaA/CmuA, also MtsA, or methyltransferase 2 (MT2) MT2-A and MT2-M isozymes, are methylcobamide:Coenzyme M methyltransferases, which play a role in metabolic pathways of methane formation from various substrates, such as methylated...; Region: Mta_CmuA_like; cd03307
635013002786	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013002787	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
635013002788	catalytic loop [active]
635013002789	iron binding site [ion binding]; other site
635013002790	tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979
635013002791	Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798
635013002792	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
635013002793	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
635013002794	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013002795	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013002796	B12 binding site [chemical binding]; other site
635013002797	cobalt ligand [ion binding]; other site
635013002798	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
635013002799	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013002800	B12 binding site [chemical binding]; other site
635013002801	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
635013002802	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013002803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013002804	Walker A motif; other site
635013002805	ATP binding site [chemical binding]; other site
635013002806	Walker B motif; other site
635013002807	arginine finger; other site
635013002808	Helix-turn-helix domains; Region: HTH; cl00088
635013002809	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
635013002810	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013002811	B12 binding site [chemical binding]; other site
635013002812	Methanol-cobalamin methyltransferase B subunit; Region: MtaB; pfam12176
635013002813	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
635013002814	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013002815	B12 binding site [chemical binding]; other site
635013002816	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
635013002817	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002818	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; cl08458
635013002819	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
635013002820	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013002821	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013002822	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
635013002823	active site
635013002824	FMN binding site [chemical binding]; other site
635013002825	substrate binding site [chemical binding]; other site
635013002826	3Fe-4S cluster binding site [ion binding]; other site
635013002827	PAS fold; Region: PAS_4; pfam08448
635013002828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013002829	metal binding site [ion binding]; metal-binding site
635013002830	active site
635013002831	I-site; other site
635013002832	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
635013002833	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
635013002834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
635013002835	PAS fold; Region: PAS_4; pfam08448
635013002836	PAS domain S-box; Region: sensory_box; TIGR00229
635013002837	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
635013002838	putative active site [active]
635013002839	heme pocket [chemical binding]; other site
635013002840	PAS fold; Region: PAS; pfam00989
635013002841	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
635013002842	putative active site [active]
635013002843	heme pocket [chemical binding]; other site
635013002844	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013002845	metal binding site [ion binding]; metal-binding site
635013002846	active site
635013002847	I-site; other site
635013002848	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
635013002849	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
635013002850	Helix-turn-helix domains; Region: HTH; cl00088
635013002851	Predicted permease; Region: DUF318; pfam03773
635013002852	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
635013002853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
635013002854	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
635013002855	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
635013002856	Walker A/P-loop; other site
635013002857	ATP binding site [chemical binding]; other site
635013002858	Q-loop/lid; other site
635013002859	ABC transporter signature motif; other site
635013002860	Walker B; other site
635013002861	D-loop; other site
635013002862	H-loop/switch region; other site
635013002863	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
635013002864	NMT1-like family; Region: NMT1_2; cl15260
635013002865	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
635013002866	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
635013002867	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
635013002868	Family description; Region: UvrD_C_2; cl15862
635013002869	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
635013002870	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
635013002871	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
635013002872	active site
635013002873	metal binding site [ion binding]; metal-binding site
635013002874	DNA binding site [nucleotide binding]
635013002875	chromosome segregation protein; Provisional; Region: PRK01156
635013002876	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002877	Walker A/P-loop; other site
635013002878	ATP binding site [chemical binding]; other site
635013002879	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
635013002880	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013002881	ABC transporter signature motif; other site
635013002882	Walker B; other site
635013002883	D-loop; other site
635013002884	H-loop/switch region; other site
635013002885	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
635013002886	Rhomboid family; Region: Rhomboid; cl11446
635013002887	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
635013002888	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013002889	FeS/SAM binding site; other site
635013002890	Domain of unknown function (DUF4130; Region: DUF4130; cl14836
635013002891	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
635013002892	putative active site [active]
635013002893	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
635013002894	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
635013002895	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
635013002896	4Fe-4S binding domain; Region: Fer4; cl02805
635013002897	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
635013002898	dimer interface [polypeptide binding]; other site
635013002899	[2Fe-2S] cluster binding site [ion binding]; other site
635013002900	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
635013002901	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
635013002902	SLBB domain; Region: SLBB; pfam10531
635013002903	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
635013002904	[FeFe] hydrogenase, group B1/B3; Region: FeFe_hydrog_B1; TIGR04105
635013002905	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
635013002906	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
635013002907	putative dimer interface [polypeptide binding]; other site
635013002908	[2Fe-2S] cluster binding site [ion binding]; other site
635013002909	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
635013002910	TPR repeat; Region: TPR_11; pfam13414
635013002911	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013002912	binding surface
635013002913	TPR motif; other site
635013002914	TPR repeat; Region: TPR_11; pfam13414
635013002915	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
635013002916	The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874
635013002917	NHL repeat; Region: NHL; pfam01436
635013002918	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002919	NHL repeat; Region: NHL; pfam01436
635013002920	haloacid dehalogenase-like hydrolase family protein; Region: PLN02919
635013002921	NHL repeat; Region: NHL; pfam01436
635013002922	NHL repeat; Region: NHL; pfam01436
635013002923	NHL repeat; Region: NHL; pfam01436
635013002924	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013002925	Interdomain contacts; other site
635013002926	Cytokine receptor motif; other site
635013002927	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013002928	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002929	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013002930	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002931	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013002932	Interdomain contacts; other site
635013002933	Cytokine receptor motif; other site
635013002934	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013002935	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002936	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013002937	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002938	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
635013002939	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013002940	Interdomain contacts; other site
635013002941	Cytokine receptor motif; other site
635013002942	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013002943	Interdomain contacts; other site
635013002944	Cytokine receptor motif; other site
635013002945	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013002946	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002947	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002948	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002949	formate-dependent cytochrome c nitrite reductase, c552 subunit; Region: cyto_c552_HCOOH; TIGR03152
635013002950	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013002951	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
635013002952	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013002953	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013002954	Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287
635013002955	Probable zinc-binding domain; Region: zf-trcl; pfam13451
635013002956	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
635013002957	putative active site pocket [active]
635013002958	dimerization interface [polypeptide binding]; other site
635013002959	putative catalytic residue [active]
635013002960	hypothetical protein; Provisional; Region: PRK03636
635013002961	UPF0302 domain; Region: UPF0302; pfam08864
635013002962	IDEAL domain; Region: IDEAL; cl07452
635013002963	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
635013002964	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
635013002965	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
635013002966	generic binding surface II; other site
635013002967	generic binding surface I; other site
635013002968	Y-family of DNA polymerases; Region: PolY; cl12025
635013002969	DNA binding site [nucleotide binding]
635013002970	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
635013002971	active site
635013002972	metal binding site [ion binding]; metal-binding site
635013002973	phosphoenolpyruvate synthase; Validated; Region: PRK06241
635013002974	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
635013002975	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
635013002976	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
635013002977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013002978	putative substrate translocation pore; other site
635013002979	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
635013002980	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
635013002981	diiron binding motif [ion binding]; other site
635013002982	Uncharacterized conserved protein [Function unknown]; Region: COG3287
635013002983	FIST N domain; Region: FIST; cl10701
635013002984	FIST C domain; Region: FIST_C; pfam10442
635013002985	GAF domain; Region: GAF_2; pfam13185
635013002986	GAF domain; Region: GAF; cl15785
635013002987	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013002988	metal binding site [ion binding]; metal-binding site
635013002989	active site
635013002990	I-site; other site
635013002991	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013002992	Zn2+ binding site [ion binding]; other site
635013002993	Mg2+ binding site [ion binding]; other site
635013002994	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
635013002995	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
635013002996	Amidohydrolase; Region: Amidohydro_4; pfam13147
635013002997	active site
635013002998	Helix-turn-helix domains; Region: HTH; cl00088
635013002999	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013003000	binding surface
635013003001	TPR motif; other site
635013003002	Tetratricopeptide repeat; Region: TPR_12; pfam13424
635013003003	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
635013003004	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
635013003005	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
635013003006	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
635013003007	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
635013003008	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
635013003009	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013003010	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013003011	Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849
635013003012	spermidine synthase; Provisional; Region: PRK00811
635013003013	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013003014	Arginase family; Region: Arginase; cl00306
635013003015	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
635013003016	metal-binding site [ion binding]
635013003017	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
635013003018	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013003019	S-layer homology domain; Region: SLH; pfam00395
635013003020	S-layer homology domain; Region: SLH; pfam00395
635013003021	YusW-like protein; Region: YusW; pfam14039
635013003022	Predicted transcriptional regulator [Transcription]; Region: COG2378
635013003023	Subunit 21 of Mediator complex; Region: Med21; pfam11221
635013003024	WYL domain; Region: WYL; cl14852
635013003025	DEAD-like helicases superfamily; Region: DEXDc; smart00487
635013003026	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013003027	ATP binding site [chemical binding]; other site
635013003028	putative Mg++ binding site [ion binding]; other site
635013003029	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013003030	nucleotide binding region [chemical binding]; other site
635013003031	ATP-binding site [chemical binding]; other site
635013003032	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
635013003033	helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817
635013003034	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013003035	ATP binding site [chemical binding]; other site
635013003036	putative Mg++ binding site [ion binding]; other site
635013003037	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013003038	nucleotide binding region [chemical binding]; other site
635013003039	ATP-binding site [chemical binding]; other site
635013003040	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
635013003041	Protein of unknown function DUF45; Region: DUF45; cl00636
635013003042	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
635013003043	putative active site [active]
635013003044	catalytic site [active]
635013003045	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
635013003046	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013003047	ATP binding site [chemical binding]; other site
635013003048	putative Mg++ binding site [ion binding]; other site
635013003049	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013003050	nucleotide binding region [chemical binding]; other site
635013003051	ATP-binding site [chemical binding]; other site
635013003052	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
635013003053	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
635013003054	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003055	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003056	Restriction endonuclease [Defense mechanisms]; Region: COG3587
635013003057	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013003058	ATP binding site [chemical binding]; other site
635013003059	putative Mg++ binding site [ion binding]; other site
635013003060	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
635013003061	Domain of unknown function (DUF955); Region: DUF955; cl01076
635013003062	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
635013003063	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013003064	TPR motif; other site
635013003065	TPR repeat; Region: TPR_11; pfam13414
635013003066	binding surface
635013003067	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
635013003068	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013003069	Walker A/P-loop; other site
635013003070	ATP binding site [chemical binding]; other site
635013003071	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
635013003072	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013003073	ABC transporter signature motif; other site
635013003074	Walker B; other site
635013003075	D-loop; other site
635013003076	H-loop/switch region; other site
635013003077	Divergent AAA domain; Region: AAA_4; pfam04326
635013003078	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
635013003079	DnaA N-terminal domain; Region: DnaA_N; pfam11638
635013003080	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
635013003081	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013003082	Walker A motif; other site
635013003083	ATP binding site [chemical binding]; other site
635013003084	Walker B motif; other site
635013003085	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003086	TPR repeat; Region: TPR_11; pfam13414
635013003087	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013003088	binding surface
635013003089	TPR motif; other site
635013003090	TPR repeat; Region: TPR_11; pfam13414
635013003091	NHL repeat; Region: NHL; pfam01436
635013003092	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013003093	NHL repeat; Region: NHL; pfam01436
635013003094	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
635013003095	putative FMN binding site [chemical binding]; other site
635013003096	Predicted membrane protein [Function unknown]; Region: COG2860
635013003097	UPF0126 domain; Region: UPF0126; pfam03458
635013003098	UPF0126 domain; Region: UPF0126; pfam03458
635013003099	sporulation sigma factor SigK; Reviewed; Region: PRK05803
635013003100	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013003101	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013003102	DNA binding residues [nucleotide binding]
635013003103	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
635013003104	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013003105	Walker A/P-loop; other site
635013003106	ATP binding site [chemical binding]; other site
635013003107	Q-loop/lid; other site
635013003108	ABC transporter signature motif; other site
635013003109	Walker B; other site
635013003110	D-loop; other site
635013003111	H-loop/switch region; other site
635013003112	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013003113	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
635013003114	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013003115	Walker A/P-loop; other site
635013003116	ATP binding site [chemical binding]; other site
635013003117	Q-loop/lid; other site
635013003118	ABC transporter signature motif; other site
635013003119	Walker B; other site
635013003120	D-loop; other site
635013003121	H-loop/switch region; other site
635013003122	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013003123	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
635013003124	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
635013003125	peptide binding site [polypeptide binding]; other site
635013003126	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
635013003127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013003128	dimer interface [polypeptide binding]; other site
635013003129	conserved gate region; other site
635013003130	putative PBP binding loops; other site
635013003131	ABC-ATPase subunit interface; other site
635013003132	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
635013003133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013003134	dimer interface [polypeptide binding]; other site
635013003135	conserved gate region; other site
635013003136	putative PBP binding loops; other site
635013003137	ABC-ATPase subunit interface; other site
635013003138	Family of unknown function (DUF1028); Region: DUF1028; pfam06267
635013003139	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
635013003140	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
635013003141	Glutathione synthase/Ribosomal protein S6 modification enzyme (glutaminyl transferase) [Coenzyme metabolism / Translation, ribosomal structure and biogenesis]; Region: RimK; COG0189
635013003142	Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395
635013003143	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013003144	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
635013003145	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013003146	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013003147	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013003148	Outer spore coat protein E (CotE); Region: CotE; pfam10628
635013003149	Outer spore coat protein E (CotE); Region: CotE; pfam10628
635013003150	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013003151	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
635013003152	Walker A/P-loop; other site
635013003153	ATP binding site [chemical binding]; other site
635013003154	Q-loop/lid; other site
635013003155	ABC transporter signature motif; other site
635013003156	Walker B; other site
635013003157	D-loop; other site
635013003158	H-loop/switch region; other site
635013003159	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
635013003160	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
635013003161	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
635013003162	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
635013003163	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
635013003164	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
635013003165	putative catalytic cysteine [active]
635013003166	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
635013003167	putative active site [active]
635013003168	metal binding site [ion binding]; metal-binding site
635013003169	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
635013003170	Protein export membrane protein; Region: SecD_SecF; cl14618
635013003171	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
635013003172	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
635013003173	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
635013003174	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
635013003175	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
635013003176	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
635013003177	substrate binding pocket [chemical binding]; other site
635013003178	chain length determination region; other site
635013003179	substrate-Mg2+ binding site; other site
635013003180	catalytic residues [active]
635013003181	aspartate-rich region 1; other site
635013003182	active site lid residues [active]
635013003183	aspartate-rich region 2; other site
635013003184	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
635013003185	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
635013003186	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
635013003187	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003188	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003189	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003190	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003191	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003192	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003193	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003194	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003195	TPR repeat; Region: TPR_11; pfam13414
635013003196	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013003197	binding surface
635013003198	TPR motif; other site
635013003199	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013003200	binding surface
635013003201	Tetratricopeptide repeat; Region: TPR_16; pfam13432
635013003202	TPR motif; other site
635013003203	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013003204	NHL repeat; Region: NHL; pfam01436
635013003205	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003206	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003207	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
635013003208	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
635013003209	chaperone protein DnaJ; Provisional; Region: PRK14276
635013003210	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
635013003211	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003212	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003213	decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507
635013003214	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003215	ResB-like family; Region: ResB; pfam05140
635013003216	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
635013003217	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013003218	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
635013003219	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013003220	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013003221	FeS/SAM binding site; other site
635013003222	AMP-binding enzyme; Region: AMP-binding; cl15778
635013003223	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013003224	NHL repeat; Region: NHL; pfam01436
635013003225	NHL repeat; Region: NHL; pfam01436
635013003226	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013003227	Interdomain contacts; other site
635013003228	Cytokine receptor motif; other site
635013003229	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013003230	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003231	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003232	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013003233	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013003234	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
635013003235	ResB-like family; Region: ResB; pfam05140
635013003236	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013003237	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
635013003238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003239	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
635013003240	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
635013003241	tRNA; other site
635013003242	putative tRNA binding site [nucleotide binding]; other site
635013003243	putative NADP binding site [chemical binding]; other site
635013003244	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
635013003245	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
635013003246	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
635013003247	domain interfaces; other site
635013003248	active site
635013003249	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
635013003250	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
635013003251	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
635013003252	active site
635013003253	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
635013003254	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
635013003255	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013003256	FeS/SAM binding site; other site
635013003257	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
635013003258	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
635013003259	dimer interface [polypeptide binding]; other site
635013003260	active site
635013003261	Schiff base residues; other site
635013003262	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
635013003263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013003264	FeS/SAM binding site; other site
635013003265	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
635013003266	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
635013003267	Helix-turn-helix domains; Region: HTH; cl00088
635013003268	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
635013003269	Helix-turn-helix domains; Region: HTH; cl00088
635013003270	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
635013003271	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
635013003272	inhibitor-cofactor binding pocket; inhibition site
635013003273	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013003274	catalytic residue [active]
635013003275	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
635013003276	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
635013003277	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013003278	S-adenosylmethionine binding site [chemical binding]; other site
635013003279	cell division protein FtsA; Region: ftsA; TIGR01174
635013003280	Cell division protein FtsA; Region: FtsA; cl11496
635013003281	Cell division protein FtsA; Region: FtsA; cl11496
635013003282	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
635013003283	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013003284	Zn2+ binding site [ion binding]; other site
635013003285	Mg2+ binding site [ion binding]; other site
635013003286	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
635013003287	uracil transporter; Provisional; Region: PRK10720
635013003288	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
635013003289	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
635013003290	SpoOM protein; Region: Spo0M; pfam07070
635013003291	NAD synthetase; Reviewed; Region: nadE; PRK02628
635013003292	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
635013003293	multimer interface [polypeptide binding]; other site
635013003294	active site
635013003295	catalytic triad [active]
635013003296	protein interface 1 [polypeptide binding]; other site
635013003297	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
635013003298	homodimer interface [polypeptide binding]; other site
635013003299	NAD binding pocket [chemical binding]; other site
635013003300	ATP binding pocket [chemical binding]; other site
635013003301	Mg binding site [ion binding]; other site
635013003302	active-site loop [active]
635013003303	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
635013003304	dinuclear metal binding motif [ion binding]; other site
635013003305	Sulfatase; Region: Sulfatase; cl10460
635013003306	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
635013003307	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
635013003308	P-loop; other site
635013003309	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013003310	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
635013003311	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
635013003312	ACS interaction site; other site
635013003313	CODH interaction site; other site
635013003314	cubane metal cluster (B-cluster) [ion binding]; other site
635013003315	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
635013003316	bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529
635013003317	Acetyl-CoA synthase (ACS), also known as acetyl-CoA decarbonylase, is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA.  ACS forms a heterotetramer with carbon monoxide dehydrogenase (CODH)...; Region: ACS_2; cd01917
635013003318	CODH interaction site; other site
635013003319	CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685
635013003320	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
635013003321	Putative Fe-S cluster; Region: FeS; pfam04060
635013003322	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
635013003323	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
635013003324	substrate binding pocket [chemical binding]; other site
635013003325	dimer interface [polypeptide binding]; other site
635013003326	inhibitor binding site; inhibition site
635013003327	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
635013003328	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003329	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
635013003330	4Fe-4S binding domain; Region: Fer4; cl02805
635013003331	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
635013003332	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
635013003333	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
635013003334	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
635013003335	FAD binding site [chemical binding]; other site
635013003336	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
635013003337	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
635013003338	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013003339	putative peptidoglycan binding site; other site
635013003340	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
635013003341	active site
635013003342	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
635013003343	Carbonic anhydrase alpha (vertebrate-like) group. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA; cl00012
635013003344	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
635013003345	motif II; other site
635013003346	Small acid-soluble spore protein H family; Region: SspH; cl06949
635013003347	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
635013003348	Domain of unknown function DUF39; Region: DUF39; cl14897
635013003349	NIL domain; Region: NIL; cl09633
635013003350	4Fe-4S binding domain; Region: Fer4; cl02805
635013003351	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013003352	4Fe-4S binding domain; Region: Fer4; cl02805
635013003353	ApbE family; Region: ApbE; cl00643
635013003354	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
635013003355	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
635013003356	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013003357	Transcriptional regulator; Region: Transcrip_reg; cl00361
635013003358	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
635013003359	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
635013003360	active site
635013003361	putative DNA-binding cleft [nucleotide binding]; other site
635013003362	dimer interface [polypeptide binding]; other site
635013003363	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
635013003364	RuvA N terminal domain; Region: RuvA_N; pfam01330
635013003365	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
635013003366	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
635013003367	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013003368	Walker A motif; other site
635013003369	ATP binding site [chemical binding]; other site
635013003370	Walker B motif; other site
635013003371	arginine finger; other site
635013003372	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
635013003373	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which  binds to Adenosine group; Region: Alpha_ANH_like; cd01986
635013003374	Ligand Binding Site [chemical binding]; other site
635013003375	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
635013003376	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
635013003377	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
635013003378	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013003379	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
635013003380	Stage II sporulation protein; Region: SpoIID; pfam08486
635013003381	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
635013003382	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
635013003383	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
635013003384	EamA-like transporter family; Region: EamA; cl01037
635013003385	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
635013003386	EamA-like transporter family; Region: EamA; cl01037
635013003387	EamA-like transporter family; Region: EamA; cl01037
635013003388	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
635013003389	EamA-like transporter family; Region: EamA; cl01037
635013003390	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
635013003391	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
635013003392	substrate binding pocket [chemical binding]; other site
635013003393	membrane-bound complex binding site; other site
635013003394	hinge residues; other site
635013003395	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
635013003396	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013003397	dimer interface [polypeptide binding]; other site
635013003398	conserved gate region; other site
635013003399	putative PBP binding loops; other site
635013003400	ABC-ATPase subunit interface; other site
635013003401	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
635013003402	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
635013003403	Walker A/P-loop; other site
635013003404	ATP binding site [chemical binding]; other site
635013003405	Q-loop/lid; other site
635013003406	ABC transporter signature motif; other site
635013003407	Walker B; other site
635013003408	D-loop; other site
635013003409	H-loop/switch region; other site
635013003410	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
635013003411	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013003412	Propanediol utilisation protein PduL; Region: PduL; pfam06130
635013003413	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
635013003414	Protein of unknown function (DUF3365); Region: DUF3365; pfam11845
635013003415	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
635013003416	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
635013003417	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013003418	dimer interface [polypeptide binding]; other site
635013003419	phosphorylation site [posttranslational modification]
635013003420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013003421	ATP binding site [chemical binding]; other site
635013003422	Mg2+ binding site [ion binding]; other site
635013003423	G-X-G motif; other site
635013003424	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013003425	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013003426	active site
635013003427	phosphorylation site [posttranslational modification]
635013003428	intermolecular recognition site; other site
635013003429	dimerization interface [polypeptide binding]; other site
635013003430	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013003431	DNA binding site [nucleotide binding]
635013003432	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
635013003433	Cytochrome c552; Region: Cytochrom_C552; pfam02335
635013003434	HPP family; Region: HPP; pfam04982
635013003435	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
635013003436	tRNA-guanine transglycosylases, various specificities; Region: tgt_general; TIGR00449
635013003437	Preprotein translocase subunit; Region: YajC; cl00806
635013003438	HD supefamily hydrolase [General function prediction only]; Region: COG3294
635013003439	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
635013003440	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
635013003441	Protein export membrane protein; Region: SecD_SecF; cl14618
635013003442	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
635013003443	Protein export membrane protein; Region: SecD_SecF; cl14618
635013003444	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
635013003445	DHH family; Region: DHH; pfam01368
635013003446	DHHA1 domain; Region: DHHA1; pfam02272
635013003447	HIRAN domain; Region: HIRAN; cl07418
635013003448	DEAD-like helicases superfamily; Region: DEXDc; smart00487
635013003449	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013003450	ATP binding site [chemical binding]; other site
635013003451	putative Mg++ binding site [ion binding]; other site
635013003452	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013003453	nucleotide binding region [chemical binding]; other site
635013003454	ATP-binding site [chemical binding]; other site
635013003455	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
635013003456	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013003457	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
635013003458	synthetase active site [active]
635013003459	NTP binding site [chemical binding]; other site
635013003460	metal binding site [ion binding]; metal-binding site
635013003461	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
635013003462	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
635013003463	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
635013003464	putative active site [active]
635013003465	dimerization interface [polypeptide binding]; other site
635013003466	putative tRNAtyr binding site [nucleotide binding]; other site
635013003467	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013003468	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
635013003469	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
635013003470	NodB motif; other site
635013003471	active site
635013003472	catalytic site [active]
635013003473	Cd binding site [ion binding]; other site
635013003474	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
635013003475	Ion channel; Region: Ion_trans_2; cl11596
635013003476	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
635013003477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003478	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
635013003479	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
635013003480	active site
635013003481	catalytic triad [active]
635013003482	oxyanion hole [active]
635013003483	Late competence development protein ComFB; Region: ComFB; pfam10719
635013003484	Uncharacterized protein conserved in bacteria (DUF2197); Region: DUF2197; cl11558
635013003485	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
635013003486	invasion associated secreted endopeptidase; Provisional; Region: PRK13914
635013003487	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013003488	putative peptidoglycan binding site; other site
635013003489	Flp/Fap pilin component; Region: Flp_Fap; cl01585
635013003490	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
635013003491	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013003492	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013003493	active site
635013003494	phosphorylation site [posttranslational modification]
635013003495	intermolecular recognition site; other site
635013003496	dimerization interface [polypeptide binding]; other site
635013003497	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013003498	DNA binding site [nucleotide binding]
635013003499	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
635013003500	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013003501	dimerization interface [polypeptide binding]; other site
635013003502	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013003503	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013003504	dimer interface [polypeptide binding]; other site
635013003505	phosphorylation site [posttranslational modification]
635013003506	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013003507	ATP binding site [chemical binding]; other site
635013003508	Mg2+ binding site [ion binding]; other site
635013003509	G-X-G motif; other site
635013003510	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
635013003511	FAD binding domain; Region: FAD_binding_4; pfam01565
635013003512	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013003513	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
635013003514	Cysteine-rich domain; Region: CCG; pfam02754
635013003515	Cysteine-rich domain; Region: CCG; pfam02754
635013003516	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
635013003517	PDGLE domain; Region: PDGLE; cl07986
635013003518	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
635013003519	Predicted RNA-binding protein; Region: RNA_bind_2; cl00662
635013003520	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
635013003521	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
635013003522	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
635013003523	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
635013003524	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
635013003525	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013003526	dimer interface [polypeptide binding]; other site
635013003527	conserved gate region; other site
635013003528	putative PBP binding loops; other site
635013003529	ABC-ATPase subunit interface; other site
635013003530	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
635013003531	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013003532	dimer interface [polypeptide binding]; other site
635013003533	conserved gate region; other site
635013003534	putative PBP binding loops; other site
635013003535	ABC-ATPase subunit interface; other site
635013003536	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
635013003537	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013003538	Walker A/P-loop; other site
635013003539	ATP binding site [chemical binding]; other site
635013003540	Q-loop/lid; other site
635013003541	ABC transporter signature motif; other site
635013003542	Walker B; other site
635013003543	D-loop; other site
635013003544	H-loop/switch region; other site
635013003545	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013003546	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013003547	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
635013003548	Walker A/P-loop; other site
635013003549	ATP binding site [chemical binding]; other site
635013003550	Q-loop/lid; other site
635013003551	ABC transporter signature motif; other site
635013003552	Walker B; other site
635013003553	D-loop; other site
635013003554	H-loop/switch region; other site
635013003555	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013003556	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
635013003557	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013003558	S-adenosylmethionine binding site [chemical binding]; other site
635013003559	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
635013003560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013003561	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
635013003562	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
635013003563	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
635013003564	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
635013003565	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520
635013003566	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
635013003567	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013003568	dimer interface [polypeptide binding]; other site
635013003569	conserved gate region; other site
635013003570	putative PBP binding loops; other site
635013003571	ABC-ATPase subunit interface; other site
635013003572	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
635013003573	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013003574	dimer interface [polypeptide binding]; other site
635013003575	conserved gate region; other site
635013003576	putative PBP binding loops; other site
635013003577	ABC-ATPase subunit interface; other site
635013003578	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
635013003579	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013003580	Walker A/P-loop; other site
635013003581	ATP binding site [chemical binding]; other site
635013003582	Q-loop/lid; other site
635013003583	ABC transporter signature motif; other site
635013003584	Walker B; other site
635013003585	D-loop; other site
635013003586	H-loop/switch region; other site
635013003587	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013003588	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
635013003589	Walker A/P-loop; other site
635013003590	ATP binding site [chemical binding]; other site
635013003591	Q-loop/lid; other site
635013003592	ABC transporter signature motif; other site
635013003593	Walker B; other site
635013003594	D-loop; other site
635013003595	H-loop/switch region; other site
635013003596	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
635013003597	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003598	Methyltransferase domain; Region: Methyltransf_31; pfam13847
635013003599	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013003600	S-adenosylmethionine binding site [chemical binding]; other site
635013003601	4Fe-4S binding domain; Region: Fer4; cl02805
635013003602	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
635013003603	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
635013003604	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013003605	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
635013003606	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
635013003607	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
635013003608	Predicted transporter (DUF2162); Region: DUF2162; cl01990
635013003609	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
635013003610	Uncharacterized conserved protein (DUF2149); Region: DUF2149; cl01960
635013003611	Cobalamin biosynthesis protein CobN and related Mg-chelatases [Coenzyme metabolism]; Region: CobN; COG1429
635013003612	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
635013003613	CobN/Magnesium Chelatase; Region: CobN-Mg_chel; pfam02514
635013003614	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
635013003615	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
635013003616	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
635013003617	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
635013003618	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
635013003619	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
635013003620	S-layer homology domain; Region: SLH; pfam00395
635013003621	S-layer homology domain; Region: SLH; pfam00395
635013003622	S-layer homology domain; Region: SLH; pfam00395
635013003623	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
635013003624	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
635013003625	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013003626	Cobalt transport protein; Region: CbiQ; cl00463
635013003627	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
635013003628	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
635013003629	Walker A/P-loop; other site
635013003630	ATP binding site [chemical binding]; other site
635013003631	Q-loop/lid; other site
635013003632	ABC transporter signature motif; other site
635013003633	Walker B; other site
635013003634	D-loop; other site
635013003635	H-loop/switch region; other site
635013003636	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
635013003637	Walker A/P-loop; other site
635013003638	ATP binding site [chemical binding]; other site
635013003639	Q-loop/lid; other site
635013003640	ABC transporter signature motif; other site
635013003641	Walker B; other site
635013003642	D-loop; other site
635013003643	H-loop/switch region; other site
635013003644	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
635013003645	Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808
635013003646	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
635013003647	Cobalt transport protein component CbiN; Region: CbiN; cl00842
635013003648	Cobalt transport protein; Region: CbiQ; cl00463
635013003649	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
635013003650	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
635013003651	Walker A/P-loop; other site
635013003652	ATP binding site [chemical binding]; other site
635013003653	Q-loop/lid; other site
635013003654	ABC transporter signature motif; other site
635013003655	Walker B; other site
635013003656	D-loop; other site
635013003657	H-loop/switch region; other site
635013003658	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
635013003659	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
635013003660	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
635013003661	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013003662	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
635013003663	Helix-turn-helix domains; Region: HTH; cl00088
635013003664	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
635013003665	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
635013003666	magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459
635013003667	recombinase A; Provisional; Region: recA; PRK09354
635013003668	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
635013003669	hexamer interface [polypeptide binding]; other site
635013003670	Walker A motif; other site
635013003671	ATP binding site [chemical binding]; other site
635013003672	Walker B motif; other site
635013003673	RecX family; Region: RecX; cl00936
635013003674	phosphodiesterase; Provisional; Region: PRK12704
635013003675	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013003676	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
635013003677	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
635013003678	putative active site [active]
635013003679	metal binding site [ion binding]; metal-binding site
635013003680	homodimer binding site [polypeptide binding]; other site
635013003681	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
635013003682	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
635013003683	active site
635013003684	dimer interface [polypeptide binding]; other site
635013003685	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
635013003686	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
635013003687	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013003688	homodimer interface [polypeptide binding]; other site
635013003689	catalytic residue [active]
635013003690	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013003691	putative peptidoglycan binding site; other site
635013003692	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140
635013003693	Catalytic site; other site
635013003694	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
635013003695	Spore germination protein; Region: Spore_permease; cl15802
635013003696	NMT1-like family; Region: NMT1_2; cl15260
635013003697	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
635013003698	DNA polymerase IV; Reviewed; Region: PRK03103
635013003699	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
635013003700	active site
635013003701	DNA binding site [nucleotide binding]
635013003702	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
635013003703	EamA-like transporter family; Region: EamA; cl01037
635013003704	EamA-like transporter family; Region: EamA; cl01037
635013003705	LysE type translocator; Region: LysE; cl00565
635013003706	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
635013003707	FtsX-like permease family; Region: FtsX; cl15850
635013003708	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
635013003709	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
635013003710	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
635013003711	Walker A/P-loop; other site
635013003712	ATP binding site [chemical binding]; other site
635013003713	Q-loop/lid; other site
635013003714	ABC transporter signature motif; other site
635013003715	Walker B; other site
635013003716	D-loop; other site
635013003717	H-loop/switch region; other site
635013003718	Acylphosphatase; Region: Acylphosphatase; cl00551
635013003719	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
635013003720	HypF finger; Region: zf-HYPF; pfam07503
635013003721	HypF finger; Region: zf-HYPF; pfam07503
635013003722	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
635013003723	HupF/HypC family; Region: HupF_HypC; cl00394
635013003724	Hydrogenase formation hypA family; Region: HypD; cl12072
635013003725	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
635013003726	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
635013003727	dimerization interface [polypeptide binding]; other site
635013003728	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
635013003729	ATP binding site [chemical binding]; other site
635013003730	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
635013003731	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013003732	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
635013003733	homotrimer interface [polypeptide binding]; other site
635013003734	Walker A motif; other site
635013003735	GTP binding site [chemical binding]; other site
635013003736	Walker B motif; other site
635013003737	cobyric acid synthase; Provisional; Region: PRK00784
635013003738	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013003739	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013003740	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
635013003741	catalytic triad [active]
635013003742	CobD/Cbib protein; Region: CobD_Cbib; cl00561
635013003743	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
635013003744	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013003745	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
635013003746	catalytic triad [active]
635013003747	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
635013003748	homodimer interface [polypeptide binding]; other site
635013003749	Walker A motif; other site
635013003750	ATP binding site [chemical binding]; other site
635013003751	hydroxycobalamin binding site [chemical binding]; other site
635013003752	Walker B motif; other site
635013003753	Protein involved in propanediol utilization, and related proteins (includes coumermycin biosynthetic protein), possible kinase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduX; COG4542
635013003754	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
635013003755	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
635013003756	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
635013003757	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013003758	homodimer interface [polypeptide binding]; other site
635013003759	catalytic residue [active]
635013003760	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
635013003761	catalytic core [active]
635013003762	Protein of unknown function (DUF1232); Region: DUF1232; cl01318
635013003763	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
635013003764	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
635013003765	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
635013003766	active site
635013003767	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
635013003768	FxsA cytoplasmic membrane protein; Region: FxsA; cl01148
635013003769	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
635013003770	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
635013003771	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
635013003772	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
635013003773	active site
635013003774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013003775	Walker A motif; other site
635013003776	ATP binding site [chemical binding]; other site
635013003777	Walker B motif; other site
635013003778	arginine finger; other site
635013003779	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
635013003780	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
635013003781	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
635013003782	FeoA domain; Region: FeoA; cl00838
635013003783	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
635013003784	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
635013003785	G1 box; other site
635013003786	GTP/Mg2+ binding site [chemical binding]; other site
635013003787	Switch I region; other site
635013003788	G2 box; other site
635013003789	G3 box; other site
635013003790	Switch II region; other site
635013003791	G4 box; other site
635013003792	G5 box; other site
635013003793	Nucleoside recognition; Region: Gate; cl00486
635013003794	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
635013003795	Nucleoside recognition; Region: Gate; cl00486
635013003796	ferric uptake regulator; Provisional; Region: fur; PRK09462
635013003797	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
635013003798	metal binding site 2 [ion binding]; metal-binding site
635013003799	putative DNA binding helix; other site
635013003800	metal binding site 1 [ion binding]; metal-binding site
635013003801	dimer interface [polypeptide binding]; other site
635013003802	structural Zn2+ binding site [ion binding]; other site
635013003803	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
635013003804	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
635013003805	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
635013003806	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
635013003807	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
635013003808	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
635013003809	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
635013003810	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
635013003811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003812	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013003813	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
635013003814	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
635013003815	dimer interface [polypeptide binding]; other site
635013003816	ADP-ribose binding site [chemical binding]; other site
635013003817	active site
635013003818	nudix motif; other site
635013003819	metal binding site [ion binding]; metal-binding site
635013003820	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
635013003821	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
635013003822	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
635013003823	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013003824	septum formation inhibitor; Reviewed; Region: minC; PRK00513
635013003825	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
635013003826	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
635013003827	GAF domain; Region: GAF; cl15785
635013003828	GAF domain; Region: GAF_2; pfam13185
635013003829	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013003830	metal binding site [ion binding]; metal-binding site
635013003831	active site
635013003832	I-site; other site
635013003833	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
635013003834	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013003835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013003836	active site
635013003837	phosphorylation site [posttranslational modification]
635013003838	intermolecular recognition site; other site
635013003839	dimerization interface [polypeptide binding]; other site
635013003840	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013003841	DNA binding site [nucleotide binding]
635013003842	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
635013003843	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013003844	dimerization interface [polypeptide binding]; other site
635013003845	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013003846	dimer interface [polypeptide binding]; other site
635013003847	phosphorylation site [posttranslational modification]
635013003848	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013003849	ATP binding site [chemical binding]; other site
635013003850	Mg2+ binding site [ion binding]; other site
635013003851	G-X-G motif; other site
635013003852	isoaspartyl dipeptidase; Provisional; Region: PRK10657
635013003853	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
635013003854	active site
635013003855	PilZ domain; Region: PilZ; cl01260
635013003856	Uncharacterized conserved protein [Function unknown]; Region: COG2006
635013003857	Domain of unknown function (DUF362); Region: DUF362; pfam04015
635013003858	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
635013003859	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013003860	Protein of unknown function DUF89; Region: DUF89; cl15397
635013003861	Protein of unknown function (DUF441); Region: DUF441; cl01041
635013003862	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
635013003863	rRNA interaction site [nucleotide binding]; other site
635013003864	S8 interaction site; other site
635013003865	putative laminin-1 binding site; other site
635013003866	elongation factor Ts; Reviewed; Region: tsf; PRK12332
635013003867	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
635013003868	Elongation factor TS; Region: EF_TS; pfam00889
635013003869	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
635013003870	putative nucleotide binding site [chemical binding]; other site
635013003871	uridine monophosphate binding site [chemical binding]; other site
635013003872	homohexameric interface [polypeptide binding]; other site
635013003873	ribosome recycling factor; Reviewed; Region: frr; PRK00083
635013003874	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
635013003875	hinge region; other site
635013003876	4Fe-4S binding domain; Region: Fer4; cl02805
635013003877	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
635013003878	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
635013003879	catalytic residue [active]
635013003880	putative FPP diphosphate  binding site; other site
635013003881	putative FPP binding hydrophobic cleft; other site
635013003882	dimer interface [polypeptide binding]; other site
635013003883	putative IPP diphosphate binding site; other site
635013003884	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
635013003885	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
635013003886	Domain of unknown function DUF20; Region: UPF0118; pfam01594
635013003887	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
635013003888	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
635013003889	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
635013003890	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
635013003891	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
635013003892	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
635013003893	active site
635013003894	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
635013003895	protein binding site [polypeptide binding]; other site
635013003896	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
635013003897	putative substrate binding region [chemical binding]; other site
635013003898	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
635013003899	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
635013003900	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
635013003901	prolyl-tRNA synthetase; Provisional; Region: PRK09194
635013003902	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
635013003903	dimer interface [polypeptide binding]; other site
635013003904	motif 1; other site
635013003905	active site
635013003906	motif 2; other site
635013003907	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
635013003908	putative deacylase active site [active]
635013003909	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
635013003910	active site
635013003911	motif 3; other site
635013003912	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
635013003913	anticodon binding site; other site
635013003914	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
635013003915	Ligand binding site; other site
635013003916	Putative Catalytic site; other site
635013003917	DXD motif; other site
635013003918	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
635013003919	MgtC family; Region: MgtC; pfam02308
635013003920	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
635013003921	DNA polymerase III PolC; Validated; Region: polC; PRK00448
635013003922	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
635013003923	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
635013003924	generic binding surface II; other site
635013003925	generic binding surface I; other site
635013003926	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
635013003927	active site
635013003928	substrate binding site [chemical binding]; other site
635013003929	catalytic site [active]
635013003930	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
635013003931	Transposase domain (DUF772); Region: DUF772; cl15789
635013003932	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013003933	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
635013003934	ribosome maturation protein RimP; Reviewed; Region: PRK00092
635013003935	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
635013003936	Sm1 motif; other site
635013003937	predicted subunit interaction site [polypeptide binding]; other site
635013003938	RNA binding pocket [nucleotide binding]; other site
635013003939	Sm2 motif; other site
635013003940	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
635013003941	NusA N-terminal domain; Region: NusA_N; pfam08529
635013003942	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
635013003943	RNA binding site [nucleotide binding]; other site
635013003944	homodimer interface [polypeptide binding]; other site
635013003945	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
635013003946	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
635013003947	G-X-X-G motif; other site
635013003948	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
635013003949	putative RNA binding cleft [nucleotide binding]; other site
635013003950	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
635013003951	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
635013003952	translation initiation factor IF-2; Region: IF-2; TIGR00487
635013003953	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
635013003954	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
635013003955	G1 box; other site
635013003956	putative GEF interaction site [polypeptide binding]; other site
635013003957	GTP/Mg2+ binding site [chemical binding]; other site
635013003958	Switch I region; other site
635013003959	G2 box; other site
635013003960	G3 box; other site
635013003961	Switch II region; other site
635013003962	G4 box; other site
635013003963	G5 box; other site
635013003964	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
635013003965	Translation-initiation factor 2; Region: IF-2; pfam11987
635013003966	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
635013003967	Ribosome-binding factor A; Region: RBFA; cl00542
635013003968	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
635013003969	DHH family; Region: DHH; pfam01368
635013003970	DHHA1 domain; Region: DHHA1; pfam02272
635013003971	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
635013003972	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
635013003973	RNA binding site [nucleotide binding]; other site
635013003974	active site
635013003975	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
635013003976	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
635013003977	active site
635013003978	Riboflavin kinase; Region: Flavokinase; cl03312
635013003979	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
635013003980	16S/18S rRNA binding site [nucleotide binding]; other site
635013003981	S13e-L30e interaction site [polypeptide binding]; other site
635013003982	25S rRNA binding site [nucleotide binding]; other site
635013003983	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
635013003984	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
635013003985	RNase E interface [polypeptide binding]; other site
635013003986	trimer interface [polypeptide binding]; other site
635013003987	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
635013003988	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
635013003989	RNase E interface [polypeptide binding]; other site
635013003990	trimer interface [polypeptide binding]; other site
635013003991	active site
635013003992	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
635013003993	putative nucleic acid binding region [nucleotide binding]; other site
635013003994	G-X-X-G motif; other site
635013003995	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
635013003996	RNA binding site [nucleotide binding]; other site
635013003997	domain interface; other site
635013003998	endonuclease IV; Provisional; Region: PRK01060
635013003999	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
635013004000	AP (apurinic/apyrimidinic) site pocket; other site
635013004001	DNA interaction; other site
635013004002	Metal-binding active site; metal-binding site
635013004003	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
635013004004	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013004005	putative peptidoglycan binding site; other site
635013004006	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
635013004007	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013004008	putative peptidoglycan binding site; other site
635013004009	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013004010	putative peptidoglycan binding site; other site
635013004011	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
635013004012	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013004013	putative peptidoglycan binding site; other site
635013004014	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
635013004015	active site
635013004016	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
635013004017	NodB motif; other site
635013004018	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
635013004019	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013004020	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
635013004021	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
635013004022	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
635013004023	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
635013004024	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
635013004025	trimer interface [polypeptide binding]; other site
635013004026	active site
635013004027	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013004028	dihydrodipicolinate reductase; Provisional; Region: PRK00048
635013004029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004030	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
635013004031	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
635013004032	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
635013004033	NAD(P) binding site [chemical binding]; other site
635013004034	Flavoprotein; Region: Flavoprotein; cl08021
635013004035	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
635013004036	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004037	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
635013004038	aspartate kinase I; Reviewed; Region: PRK08210
635013004039	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
635013004040	nucleotide binding site [chemical binding]; other site
635013004041	substrate binding site [chemical binding]; other site
635013004042	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
635013004043	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
635013004044	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
635013004045	dihydrodipicolinate synthase; Region: dapA; TIGR00674
635013004046	dimer interface [polypeptide binding]; other site
635013004047	active site
635013004048	catalytic residue [active]
635013004049	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
635013004050	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013004051	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
635013004052	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
635013004053	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
635013004054	active site
635013004055	YlzJ-like protein; Region: YlzJ; pfam14035
635013004056	Bacitracin resistance protein BacA; Region: BacA; cl00858
635013004057	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
635013004058	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013004059	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
635013004060	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
635013004061	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
635013004062	ligand binding site [chemical binding]; other site
635013004063	Predicted integral membrane protein [Function unknown]; Region: COG0392
635013004064	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
635013004065	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
635013004066	Ligand binding site; other site
635013004067	Putative Catalytic site; other site
635013004068	DXD motif; other site
635013004069	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
635013004070	Sulfatase; Region: Sulfatase; cl10460
635013004071	Protein of unknown function (DUF2029); Region: DUF2029; cl09812
635013004072	Uncharacterized membrane protein [Function unknown]; Region: COG3949
635013004073	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
635013004074	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
635013004075	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
635013004076	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
635013004077	active site residue [active]
635013004078	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013004079	active site
635013004080	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
635013004081	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013004082	non-specific DNA binding site [nucleotide binding]; other site
635013004083	salt bridge; other site
635013004084	sequence-specific DNA binding site [nucleotide binding]; other site
635013004085	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
635013004086	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013004087	binding surface
635013004088	TPR motif; other site
635013004089	TPR repeat; Region: TPR_11; pfam13414
635013004090	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013004091	NHL repeat; Region: NHL; pfam01436
635013004092	NHL repeat; Region: NHL; pfam01436
635013004093	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013004094	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013004095	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013004096	NHL repeat; Region: NHL; pfam01436
635013004097	NHL repeat; Region: NHL; pfam01436
635013004098	NHL repeat; Region: NHL; pfam01436
635013004099	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
635013004100	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013004101	Interdomain contacts; other site
635013004102	Cytokine receptor motif; other site
635013004103	Bacterial Ig-like domain; Region: Big_5; cl01012
635013004104	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013004105	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013004106	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013004107	NHL repeat; Region: NHL; pfam01436
635013004108	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013004109	Interdomain contacts; other site
635013004110	Cytokine receptor motif; other site
635013004111	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013004112	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013004113	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013004114	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013004115	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013004116	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013004117	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
635013004118	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013004119	Protein of unknown function (DUF520); Region: DUF520; cl00723
635013004120	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
635013004121	active site
635013004122	NTP binding site [chemical binding]; other site
635013004123	metal binding triad [ion binding]; metal-binding site
635013004124	antibiotic binding site [chemical binding]; other site
635013004125	uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904
635013004126	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013004127	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
635013004128	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
635013004129	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
635013004130	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013004131	FeS/SAM binding site; other site
635013004132	TRAM domain; Region: TRAM; cl01282
635013004133	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
635013004134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013004135	Walker A motif; other site
635013004136	ATP binding site [chemical binding]; other site
635013004137	Walker B motif; other site
635013004138	arginine finger; other site
635013004139	Peptidase family M41; Region: Peptidase_M41; pfam01434
635013004140	competence damage-inducible protein A; Provisional; Region: PRK00549
635013004141	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
635013004142	putative MPT binding site; other site
635013004143	Competence-damaged protein; Region: CinA; cl00666
635013004144	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
635013004145	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
635013004146	active site
635013004147	metal binding site [ion binding]; metal-binding site
635013004148	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
635013004149	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
635013004150	ATP binding site [chemical binding]; other site
635013004151	Mg++ binding site [ion binding]; other site
635013004152	motif III; other site
635013004153	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013004154	nucleotide binding region [chemical binding]; other site
635013004155	ATP-binding site [chemical binding]; other site
635013004156	DbpA RNA binding domain; Region: DbpA; pfam03880
635013004157	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013004158	Zn2+ binding site [ion binding]; other site
635013004159	Mg2+ binding site [ion binding]; other site
635013004160	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004161	Ribulose 1,5-bisphosphate synthetase, converts PRPP to RuBP, flavoprotein [Carbohydrate    transport and metabolism]; Region: THI4; COG1635
635013004162	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
635013004163	thiamine phosphate binding site [chemical binding]; other site
635013004164	active site
635013004165	pyrophosphate binding site [ion binding]; other site
635013004166	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
635013004167	ABC-2 type transporter; Region: ABC2_membrane; cl11417
635013004168	nodulation ABC transporter NodI; Provisional; Region: PRK13537
635013004169	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013004170	Walker A/P-loop; other site
635013004171	ATP binding site [chemical binding]; other site
635013004172	Q-loop/lid; other site
635013004173	ABC transporter signature motif; other site
635013004174	Walker B; other site
635013004175	D-loop; other site
635013004176	H-loop/switch region; other site
635013004177	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
635013004178	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
635013004179	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
635013004180	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
635013004181	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
635013004182	inhibitor-cofactor binding pocket; inhibition site
635013004183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013004184	catalytic residue [active]
635013004185	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004186	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
635013004187	NAD(P) binding pocket [chemical binding]; other site
635013004188	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004189	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
635013004190	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
635013004191	RelB antitoxin; Region: RelB; cl01171
635013004192	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
635013004193	Putative transposase; Region: Y2_Tnp; pfam04986
635013004194	integron integrase; Region: integrase_gron; TIGR02249
635013004195	IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193
635013004196	Int/Topo IB signature motif; other site
635013004197	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013004198	non-specific DNA binding site [nucleotide binding]; other site
635013004199	salt bridge; other site
635013004200	sequence-specific DNA binding site [nucleotide binding]; other site
635013004201	Transposase, Mutator family; Region: Transposase_mut; pfam00872
635013004202	MULE transposase domain; Region: MULE; pfam10551
635013004203	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
635013004204	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
635013004205	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; cl00782
635013004206	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
635013004207	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
635013004208	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
635013004209	Walker A/P-loop; other site
635013004210	ATP binding site [chemical binding]; other site
635013004211	Q-loop/lid; other site
635013004212	ABC transporter signature motif; other site
635013004213	Walker B; other site
635013004214	D-loop; other site
635013004215	H-loop/switch region; other site
635013004216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013004217	dimer interface [polypeptide binding]; other site
635013004218	conserved gate region; other site
635013004219	putative PBP binding loops; other site
635013004220	ABC-ATPase subunit interface; other site
635013004221	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
635013004222	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
635013004223	substrate binding pocket [chemical binding]; other site
635013004224	membrane-bound complex binding site; other site
635013004225	hinge residues; other site
635013004226	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
635013004227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013004228	Walker A motif; other site
635013004229	ATP binding site [chemical binding]; other site
635013004230	Walker B motif; other site
635013004231	arginine finger; other site
635013004232	Integrase core domain; Region: rve; cl01316
635013004233	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
635013004234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013004235	Major Facilitator Superfamily; Region: MFS_1; pfam07690
635013004236	putative substrate translocation pore; other site
635013004237	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
635013004238	Integral membrane protein TerC family; Region: TerC; cl10468
635013004239	Protein of unknown function (DUF502); Region: DUF502; cl01107
635013004240	Protein of unknown function (DUF421); Region: DUF421; cl00990
635013004241	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
635013004242	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
635013004243	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013004244	FeS/SAM binding site; other site
635013004245	Protein of unknown function (DUF964); Region: DUF964; cl01483
635013004246	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
635013004247	MutS domain I; Region: MutS_I; pfam01624
635013004248	MutS domain II; Region: MutS_II; pfam05188
635013004249	MutS family domain IV; Region: MutS_IV; pfam05190
635013004250	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
635013004251	Walker A/P-loop; other site
635013004252	ATP binding site [chemical binding]; other site
635013004253	Q-loop/lid; other site
635013004254	ABC transporter signature motif; other site
635013004255	Walker B; other site
635013004256	D-loop; other site
635013004257	H-loop/switch region; other site
635013004258	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
635013004259	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
635013004260	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
635013004261	Histone deacetylase domain; Region: Hist_deacetyl; cl02986
635013004262	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
635013004263	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013004264	ATP binding site [chemical binding]; other site
635013004265	Mg2+ binding site [ion binding]; other site
635013004266	G-X-G motif; other site
635013004267	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
635013004268	ATP binding site [chemical binding]; other site
635013004269	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
635013004270	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004271	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013004272	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
635013004273	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
635013004274	Sm1 motif; other site
635013004275	intra - hexamer interaction site; other site
635013004276	inter - hexamer interaction site [polypeptide binding]; other site
635013004277	nucleotide binding pocket [chemical binding]; other site
635013004278	Sm2 motif; other site
635013004279	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
635013004280	IHF dimer interface [polypeptide binding]; other site
635013004281	IHF - DNA interface [nucleotide binding]; other site
635013004282	stage V sporulation protein K; Region: spore_V_K; TIGR02881
635013004283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013004284	Walker A motif; other site
635013004285	ATP binding site [chemical binding]; other site
635013004286	Walker B motif; other site
635013004287	arginine finger; other site
635013004288	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
635013004289	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
635013004290	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
635013004291	catalytic residue [active]
635013004292	Response regulator receiver domain; Region: Response_reg; pfam00072
635013004293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013004294	active site
635013004295	phosphorylation site [posttranslational modification]
635013004296	intermolecular recognition site; other site
635013004297	dimerization interface [polypeptide binding]; other site
635013004298	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013004299	metal binding site [ion binding]; metal-binding site
635013004300	active site
635013004301	Protein of unknown function (DUF456); Region: DUF456; cl01069
635013004302	Helix-turn-helix domains; Region: HTH; cl00088
635013004303	LexA repressor; Validated; Region: PRK00215
635013004304	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
635013004305	Catalytic site [active]
635013004306	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
635013004307	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004308	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
635013004309	PAS domain; Region: PAS_9; pfam13426
635013004310	putative active site [active]
635013004311	heme pocket [chemical binding]; other site
635013004312	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
635013004313	Helix-turn-helix domains; Region: HTH; cl00088
635013004314	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
635013004315	Fumarase C-terminus; Region: Fumerase_C; cl00795
635013004316	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
635013004317	Malic enzyme, N-terminal domain; Region: malic; pfam00390
635013004318	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
635013004319	putative NAD(P) binding site [chemical binding]; other site
635013004320	proteins similar to Escherichia coli yceG; Region: yceG_like; cl00675
635013004321	Protein of unknown function (DUF342); Region: DUF342; pfam03961
635013004322	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
635013004323	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013004324	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
635013004325	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013004326	DNA binding residues [nucleotide binding]
635013004327	CheD chemotactic sensory transduction; Region: CheD; cl00810
635013004328	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
635013004329	Chemotaxis phosphatase CheX; Region: CheX; cl15816
635013004330	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
635013004331	putative CheA interaction surface; other site
635013004332	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
635013004333	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
635013004334	putative binding surface; other site
635013004335	active site
635013004336	P2 response regulator binding domain; Region: P2; pfam07194
635013004337	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
635013004338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013004339	ATP binding site [chemical binding]; other site
635013004340	Mg2+ binding site [ion binding]; other site
635013004341	G-X-G motif; other site
635013004342	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
635013004343	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
635013004344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013004345	active site
635013004346	phosphorylation site [posttranslational modification]
635013004347	intermolecular recognition site; other site
635013004348	dimerization interface [polypeptide binding]; other site
635013004349	CheB methylesterase; Region: CheB_methylest; pfam01339
635013004350	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
635013004351	Flagellar protein YcgR; Region: YcgR_2; pfam12945
635013004352	PilZ domain; Region: PilZ; cl01260
635013004353	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
635013004354	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
635013004355	P-loop; other site
635013004356	ADP binding residues [chemical binding]; other site
635013004357	Switch I; other site
635013004358	Switch II; other site
635013004359	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
635013004360	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013004361	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
635013004362	FHIPEP family; Region: FHIPEP; pfam00771
635013004363	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
635013004364	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
635013004365	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
635013004366	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
635013004367	FliP family; Region: FliP; cl00593
635013004368	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
635013004369	Response regulator receiver domain; Region: Response_reg; pfam00072
635013004370	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013004371	active site
635013004372	phosphorylation site [posttranslational modification]
635013004373	intermolecular recognition site; other site
635013004374	dimerization interface [polypeptide binding]; other site
635013004375	flagellar motor switch protein; Validated; Region: PRK08119
635013004376	Chemotaxis phosphatase CheX; Region: CheX; cl15816
635013004377	Chemotaxis phosphatase CheX; Region: CheX; cl15816
635013004378	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
635013004379	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
635013004380	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
635013004381	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
635013004382	Flagellar protein (FlbD); Region: FlbD; cl00683
635013004383	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
635013004384	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
635013004385	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
635013004386	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
635013004387	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
635013004388	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06009
635013004389	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
635013004390	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
635013004391	MgtE intracellular N domain; Region: MgtE_N; cl15244
635013004392	flagellar biosynthesis chaperone; Validated; Region: fliJ; cl09161
635013004393	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
635013004394	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
635013004395	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
635013004396	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
635013004397	Walker A motif/ATP binding site; other site
635013004398	Walker B motif; other site
635013004399	flagellar assembly protein H; Validated; Region: fliH; PRK06669
635013004400	Flagellar assembly protein FliH; Region: FliH; pfam02108
635013004401	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
635013004402	FliG C-terminal domain; Region: FliG_C; pfam01706
635013004403	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
635013004404	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
635013004405	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
635013004406	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
635013004407	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
635013004408	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
635013004409	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
635013004410	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
635013004411	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
635013004412	transcriptional repressor CodY; Validated; Region: PRK04158
635013004413	CodY GAF-like domain; Region: CodY; pfam06018
635013004414	Helix-turn-helix domains; Region: HTH; cl00088
635013004415	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
635013004416	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013004417	Walker A motif; other site
635013004418	ATP binding site [chemical binding]; other site
635013004419	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013004420	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
635013004421	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
635013004422	active site
635013004423	HslU subunit interaction site [polypeptide binding]; other site
635013004424	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
635013004425	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
635013004426	Int/Topo IB signature motif; other site
635013004427	active site
635013004428	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
635013004429	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004430	DNA topoisomerase I; Validated; Region: PRK05582
635013004431	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
635013004432	active site
635013004433	interdomain interaction site; other site
635013004434	putative metal-binding site [ion binding]; other site
635013004435	nucleotide binding site [chemical binding]; other site
635013004436	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
635013004437	domain I; other site
635013004438	DNA binding groove [nucleotide binding]
635013004439	phosphate binding site [ion binding]; other site
635013004440	domain II; other site
635013004441	domain III; other site
635013004442	nucleotide binding site [chemical binding]; other site
635013004443	catalytic site [active]
635013004444	domain IV; other site
635013004445	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
635013004446	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
635013004447	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
635013004448	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
635013004449	Helix-turn-helix domains; Region: HTH; cl00088
635013004450	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
635013004451	nucleotide binding site [chemical binding]; other site
635013004452	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
635013004453	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
635013004454	active site
635013004455	DNA binding site [nucleotide binding]
635013004456	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
635013004457	DNA binding site [nucleotide binding]
635013004458	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
635013004459	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
635013004460	putative DNA binding site [nucleotide binding]; other site
635013004461	putative homodimer interface [polypeptide binding]; other site
635013004462	Uncharacterized conserved protein [Function unknown]; Region: COG1751
635013004463	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
635013004464	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
635013004465	4Fe-4S binding domain; Region: Fer4; cl02805
635013004466	4Fe-4S binding domain; Region: Fer4; cl02805
635013004467	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013004468	putative peptidoglycan binding site; other site
635013004469	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013004470	putative peptidoglycan binding site; other site
635013004471	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
635013004472	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
635013004473	putative catalytic site [active]
635013004474	putative metal binding site [ion binding]; other site
635013004475	putative phosphate binding site [ion binding]; other site
635013004476	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
635013004477	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
635013004478	active site
635013004479	motif I; other site
635013004480	motif II; other site
635013004481	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
635013004482	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
635013004483	Precorrin-8X methylmutase; Region: CbiC; pfam02570
635013004484	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
635013004485	putative active site [active]
635013004486	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
635013004487	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
635013004488	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
635013004489	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
635013004490	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
635013004491	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
635013004492	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
635013004493	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
635013004494	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
635013004495	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
635013004496	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
635013004497	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
635013004498	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
635013004499	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013004500	S-adenosylmethionine binding site [chemical binding]; other site
635013004501	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
635013004502	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
635013004503	CbiD; Region: CbiD; cl00828
635013004504	hypothetical protein; Validated; Region: PRK08116
635013004505	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013004506	Walker A motif; other site
635013004507	ATP binding site [chemical binding]; other site
635013004508	Walker B motif; other site
635013004509	arginine finger; other site
635013004510	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
635013004511	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
635013004512	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013004513	Zn2+ binding site [ion binding]; other site
635013004514	Mg2+ binding site [ion binding]; other site
635013004515	histidinol-phosphatase; Provisional; Region: PRK07328
635013004516	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
635013004517	active site
635013004518	metal binding site [ion binding]; metal-binding site
635013004519	Rubrerythrin [Energy production and conversion]; Region: COG1592
635013004520	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
635013004521	binuclear metal center [ion binding]; other site
635013004522	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
635013004523	iron binding site [ion binding]; other site
635013004524	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
635013004525	Membrane transport protein; Region: Mem_trans; cl09117
635013004526	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772
635013004527	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004528	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
635013004529	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
635013004530	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
635013004531	GTP-binding protein Der; Reviewed; Region: PRK00093
635013004532	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
635013004533	G1 box; other site
635013004534	GTP/Mg2+ binding site [chemical binding]; other site
635013004535	Switch I region; other site
635013004536	G2 box; other site
635013004537	Switch II region; other site
635013004538	G3 box; other site
635013004539	G4 box; other site
635013004540	G5 box; other site
635013004541	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
635013004542	G1 box; other site
635013004543	GTP/Mg2+ binding site [chemical binding]; other site
635013004544	Switch I region; other site
635013004545	G2 box; other site
635013004546	G3 box; other site
635013004547	Switch II region; other site
635013004548	G4 box; other site
635013004549	G5 box; other site
635013004550	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
635013004551	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
635013004552	Protein of unknown function (DUF512); Region: DUF512; pfam04459
635013004553	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
635013004554	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
635013004555	YIEGIA protein; Region: YIEGIA; pfam14045
635013004556	stage II sporulation protein P; Region: spore_II_P; TIGR02867
635013004557	Protein of unknown function (DUF1614); Region: DUF1614; cl15407
635013004558	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
635013004559	LytB protein; Region: LYTB; cl00507
635013004560	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
635013004561	RNA binding site [nucleotide binding]; other site
635013004562	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
635013004563	RNA binding site [nucleotide binding]; other site
635013004564	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
635013004565	RNA binding site [nucleotide binding]; other site
635013004566	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
635013004567	RNA binding site [nucleotide binding]; other site
635013004568	domain interface; other site
635013004569	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
635013004570	putative acyl-acceptor binding pocket; other site
635013004571	cytidylate kinase; Provisional; Region: cmk; PRK00023
635013004572	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
635013004573	CMP-binding site; other site
635013004574	The sites determining sugar specificity; other site
635013004575	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
635013004576	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
635013004577	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013004578	dimerization interface [polypeptide binding]; other site
635013004579	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013004580	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013004581	dimer interface [polypeptide binding]; other site
635013004582	putative CheW interface [polypeptide binding]; other site
635013004583	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
635013004584	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
635013004585	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
635013004586	hinge; other site
635013004587	active site
635013004588	prephenate dehydrogenase; Validated; Region: PRK06545
635013004589	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004590	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
635013004591	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
635013004592	NeuB family; Region: NeuB; cl00496
635013004593	NeuB family; Region: NeuB; cl00496
635013004594	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
635013004595	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
635013004596	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
635013004597	substrate binding site [chemical binding]; other site
635013004598	active site
635013004599	catalytic residues [active]
635013004600	heterodimer interface [polypeptide binding]; other site
635013004601	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
635013004602	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
635013004603	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013004604	catalytic residue [active]
635013004605	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
635013004606	active site
635013004607	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
635013004608	active site
635013004609	ribulose/triose binding site [chemical binding]; other site
635013004610	phosphate binding site [ion binding]; other site
635013004611	substrate (anthranilate) binding pocket [chemical binding]; other site
635013004612	product (indole) binding pocket [chemical binding]; other site
635013004613	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
635013004614	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
635013004615	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
635013004616	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
635013004617	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
635013004618	glutamine binding [chemical binding]; other site
635013004619	catalytic triad [active]
635013004620	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
635013004621	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
635013004622	chorismate binding enzyme; Region: Chorismate_bind; cl10555
635013004623	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
635013004624	homotrimer interaction site [polypeptide binding]; other site
635013004625	active site
635013004626	HutP; Region: HutP; cl07944
635013004627	flavoprotein, HI0933 family; Region: TIGR00275
635013004628	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004629	LrgB-like family; Region: LrgB; cl00596
635013004630	LrgA family; Region: LrgA; cl00608
635013004631	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
635013004632	LysE type translocator; Region: LysE; cl00565
635013004633	Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470
635013004634	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013004635	non-specific DNA binding site [nucleotide binding]; other site
635013004636	salt bridge; other site
635013004637	sequence-specific DNA binding site [nucleotide binding]; other site
635013004638	HDOD domain; Region: HDOD; pfam08668
635013004639	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013004640	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
635013004641	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
635013004642	RNA binding surface [nucleotide binding]; other site
635013004643	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
635013004644	active site
635013004645	Nucleoside recognition; Region: Gate; cl00486
635013004646	Nucleoside recognition; Region: Gate; cl00486
635013004647	Glucose inhibited division protein A; Region: GIDA; pfam01134
635013004648	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004649	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004650	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
635013004651	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
635013004652	Helix-turn-helix domains; Region: HTH; cl00088
635013004653	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
635013004654	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
635013004655	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
635013004656	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
635013004657	ScpA/B protein; Region: ScpA_ScpB; cl00598
635013004658	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
635013004659	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
635013004660	active site
635013004661	HIGH motif; other site
635013004662	dimer interface [polypeptide binding]; other site
635013004663	KMSKS motif; other site
635013004664	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
635013004665	active site
635013004666	putative substrate binding region [chemical binding]; other site
635013004667	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
635013004668	DHH family; Region: DHH; pfam01368
635013004669	FOG: CBS domain [General function prediction only]; Region: COG0517
635013004670	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
635013004671	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
635013004672	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
635013004673	active site
635013004674	NTP binding site [chemical binding]; other site
635013004675	metal binding triad [ion binding]; metal-binding site
635013004676	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
635013004677	diaminopimelate decarboxylase; Region: lysA; TIGR01048
635013004678	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
635013004679	active site
635013004680	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
635013004681	substrate binding site [chemical binding]; other site
635013004682	catalytic residues [active]
635013004683	dimer interface [polypeptide binding]; other site
635013004684	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
635013004685	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
635013004686	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
635013004687	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
635013004688	active site
635013004689	8-oxo-dGMP binding site [chemical binding]; other site
635013004690	nudix motif; other site
635013004691	metal binding site [ion binding]; metal-binding site
635013004692	Domain of unknown function (DUF3786); Region: DUF3786; pfam12654
635013004693	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
635013004694	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
635013004695	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
635013004696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
635013004697	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
635013004698	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
635013004699	Stage V sporulation protein AE1; Region: SpoVAE; pfam14097
635013004700	SpoVA protein; Region: SpoVA; cl04298
635013004701	stage V sporulation protein AD; Validated; Region: PRK08304
635013004702	stage V sporulation protein AD; Provisional; Region: PRK12404
635013004703	SpoVA protein; Region: SpoVA; cl04298
635013004704	Dodecin; Region: Dodecin; cl01328
635013004705	sporulation sigma factor SigF; Validated; Region: PRK05572
635013004706	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013004707	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
635013004708	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013004709	DNA binding residues [nucleotide binding]
635013004710	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
635013004711	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013004712	ATP binding site [chemical binding]; other site
635013004713	Mg2+ binding site [ion binding]; other site
635013004714	G-X-G motif; other site
635013004715	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
635013004716	anti sigma factor interaction site; other site
635013004717	regulatory phosphorylation site [posttranslational modification]; other site
635013004718	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
635013004719	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013004720	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
635013004721	Amino acid permease; Region: AA_permease_2; pfam13520
635013004722	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
635013004723	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
635013004724	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
635013004725	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
635013004726	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
635013004727	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
635013004728	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
635013004729	Sulfatase; Region: Sulfatase; cl10460
635013004730	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
635013004731	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
635013004732	Int/Topo IB signature motif; other site
635013004733	active site
635013004734	Integral membrane protein DUF95; Region: DUF95; cl00572
635013004735	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
635013004736	PHP-associated; Region: PHP_C; pfam13263
635013004737	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
635013004738	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
635013004739	peptidase T-like protein; Region: PepT-like; TIGR01883
635013004740	metal binding site [ion binding]; metal-binding site
635013004741	putative dimer interface [polypeptide binding]; other site
635013004742	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
635013004743	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
635013004744	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
635013004745	TPP-binding site [chemical binding]; other site
635013004746	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
635013004747	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
635013004748	dimer interface [polypeptide binding]; other site
635013004749	PYR/PP interface [polypeptide binding]; other site
635013004750	TPP binding site [chemical binding]; other site
635013004751	substrate binding site [chemical binding]; other site
635013004752	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
635013004753	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013004754	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013004755	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
635013004756	AMP-binding enzyme; Region: AMP-binding; cl15778
635013004757	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013004758	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013004759	non-specific DNA binding site [nucleotide binding]; other site
635013004760	salt bridge; other site
635013004761	sequence-specific DNA binding site [nucleotide binding]; other site
635013004762	Cupin domain; Region: Cupin_2; cl09118
635013004763	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
635013004764	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
635013004765	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
635013004766	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
635013004767	putative active site [active]
635013004768	heme pocket [chemical binding]; other site
635013004769	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013004770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013004771	Walker A motif; other site
635013004772	ATP binding site [chemical binding]; other site
635013004773	Walker B motif; other site
635013004774	arginine finger; other site
635013004775	Helix-turn-helix domains; Region: HTH; cl00088
635013004776	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
635013004777	Mg++ binding site [ion binding]; other site
635013004778	putative catalytic motif [active]
635013004779	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
635013004780	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
635013004781	Ligand binding site; other site
635013004782	Putative Catalytic site; other site
635013004783	DXD motif; other site
635013004784	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
635013004785	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
635013004786	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
635013004787	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
635013004788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013004789	active site
635013004790	phosphorylation site [posttranslational modification]
635013004791	intermolecular recognition site; other site
635013004792	dimerization interface [polypeptide binding]; other site
635013004793	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
635013004794	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
635013004795	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
635013004796	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
635013004797	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
635013004798	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
635013004799	Walker A/P-loop; other site
635013004800	ATP binding site [chemical binding]; other site
635013004801	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
635013004802	ABC transporter signature motif; other site
635013004803	Walker B; other site
635013004804	D-loop; other site
635013004805	H-loop/switch region; other site
635013004806	Arginine repressor [Transcription]; Region: ArgR; COG1438
635013004807	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
635013004808	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
635013004809	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004811	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
635013004812	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
635013004813	Transposase domain (DUF772); Region: DUF772; cl15789
635013004814	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013004815	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
635013004816	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
635013004817	RNA binding surface [nucleotide binding]; other site
635013004818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
635013004819	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
635013004820	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
635013004821	TPP-binding site; other site
635013004822	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
635013004823	PYR/PP interface [polypeptide binding]; other site
635013004824	dimer interface [polypeptide binding]; other site
635013004825	TPP binding site [chemical binding]; other site
635013004826	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
635013004827	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
635013004828	substrate binding pocket [chemical binding]; other site
635013004829	chain length determination region; other site
635013004830	substrate-Mg2+ binding site; other site
635013004831	catalytic residues [active]
635013004832	aspartate-rich region 1; other site
635013004833	active site lid residues [active]
635013004834	aspartate-rich region 2; other site
635013004835	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
635013004836	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
635013004837	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
635013004838	generic binding surface II; other site
635013004839	generic binding surface I; other site
635013004840	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
635013004841	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
635013004842	dimer interface [polypeptide binding]; other site
635013004843	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013004844	catalytic residue [active]
635013004845	Coat F domain; Region: Coat_F; cl15836
635013004846	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
635013004847	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
635013004848	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
635013004849	homodimer interface [polypeptide binding]; other site
635013004850	NADP binding site [chemical binding]; other site
635013004851	substrate binding site [chemical binding]; other site
635013004852	putative oxidoreductase; Provisional; Region: PRK12831
635013004853	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013004854	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013004855	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013004856	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
635013004857	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
635013004858	FAD binding pocket [chemical binding]; other site
635013004859	FAD binding motif [chemical binding]; other site
635013004860	phosphate binding motif [ion binding]; other site
635013004861	beta-alpha-beta structure motif; other site
635013004862	NAD binding pocket [chemical binding]; other site
635013004863	Iron coordination center [ion binding]; other site
635013004864	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
635013004865	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
635013004866	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
635013004867	homodimer interface [polypeptide binding]; other site
635013004868	NADP binding site [chemical binding]; other site
635013004869	substrate binding site [chemical binding]; other site
635013004870	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013004871	putative peptidoglycan binding site; other site
635013004872	Cation efflux family; Region: Cation_efflux; cl00316
635013004873	Cation efflux family; Region: Cation_efflux; cl00316
635013004874	Bacterial Ig-like domain; Region: Big_5; cl01012
635013004875	cytochrome c nitrite reductase, pentaheme subunit; Region: cyt_nit_nrfB; TIGR03146
635013004876	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
635013004877	Metal-dependent proteases with possible chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: QRI7; COG0533
635013004878	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
635013004879	putative RNA binding site [nucleotide binding]; other site
635013004880	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
635013004881	Asp23 family; Region: Asp23; cl00574
635013004882	Asp23 family; Region: Asp23; cl00574
635013004883	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
635013004884	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
635013004885	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013004886	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365
635013004887	pyruvate carboxylase subunit B; Validated; Region: PRK09282
635013004888	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
635013004889	active site
635013004890	catalytic residues [active]
635013004891	metal binding site [ion binding]; metal-binding site
635013004892	homodimer binding site [polypeptide binding]; other site
635013004893	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
635013004894	carboxyltransferase (CT) interaction site; other site
635013004895	biotinylation site [posttranslational modification]; other site
635013004896	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
635013004897	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
635013004898	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
635013004899	stage III sporulation protein AF; Region: spore_III_AF; TIGR02896
635013004900	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
635013004901	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
635013004902	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
635013004903	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
635013004904	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
635013004905	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013004906	Walker A motif; other site
635013004907	ATP binding site [chemical binding]; other site
635013004908	PAS fold; Region: PAS; pfam00989
635013004909	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013004910	PAS domain S-box; Region: sensory_box; TIGR00229
635013004911	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
635013004912	putative active site [active]
635013004913	heme pocket [chemical binding]; other site
635013004914	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013004915	metal binding site [ion binding]; metal-binding site
635013004916	active site
635013004917	I-site; other site
635013004918	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
635013004919	zinc-ribbon domain; Region: zinc_ribbon_5; cl11777
635013004920	elongation factor P; Validated; Region: PRK00529
635013004921	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
635013004922	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
635013004923	RNA binding site [nucleotide binding]; other site
635013004924	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
635013004925	RNA binding site [nucleotide binding]; other site
635013004926	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
635013004927	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
635013004928	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
635013004929	active site
635013004930	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
635013004931	trimer interface [polypeptide binding]; other site
635013004932	active site
635013004933	dimer interface [polypeptide binding]; other site
635013004934	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
635013004935	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
635013004936	CAAX protease self-immunity; Region: Abi; cl00558
635013004937	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
635013004938	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
635013004939	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
635013004940	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
635013004941	RNA/DNA hybrid binding site [nucleotide binding]; other site
635013004942	active site
635013004943	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398
635013004944	Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523
635013004945	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
635013004946	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
635013004947	active site
635013004948	dimer interface [polypeptide binding]; other site
635013004949	metal binding site [ion binding]; metal-binding site
635013004950	shikimate kinase; Provisional; Region: PRK13947
635013004951	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
635013004952	ADP binding site [chemical binding]; other site
635013004953	magnesium binding site [ion binding]; other site
635013004954	putative shikimate binding site; other site
635013004955	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
635013004956	Tetramer interface [polypeptide binding]; other site
635013004957	active site
635013004958	FMN-binding site [chemical binding]; other site
635013004959	Pilus assembly protein, PilO; Region: PilO; cl01234
635013004960	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
635013004961	Competence protein A; Region: Competence_A; pfam11104
635013004962	Cell division protein FtsA; Region: FtsA; cl11496
635013004963	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
635013004964	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
635013004965	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
635013004966	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
635013004967	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
635013004968	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
635013004969	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
635013004970	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
635013004971	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
635013004972	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
635013004973	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
635013004974	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013004975	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013004976	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
635013004977	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
635013004978	Walker A motif; other site
635013004979	ATP binding site [chemical binding]; other site
635013004980	Walker B motif; other site
635013004981	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
635013004982	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
635013004983	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
635013004984	Walker A motif; other site
635013004985	ATP binding site [chemical binding]; other site
635013004986	Walker B motif; other site
635013004987	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
635013004988	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
635013004989	DNA binding residues [nucleotide binding]
635013004990	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
635013004991	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
635013004992	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
635013004993	shikimate binding site; other site
635013004994	NAD(P) binding site [chemical binding]; other site
635013004995	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
635013004996	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
635013004997	active site
635013004998	motif I; other site
635013004999	motif II; other site
635013005000	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
635013005001	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
635013005002	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
635013005003	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
635013005004	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
635013005005	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013005006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013005007	active site
635013005008	phosphorylation site [posttranslational modification]
635013005009	intermolecular recognition site; other site
635013005010	dimerization interface [polypeptide binding]; other site
635013005011	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013005012	metal binding site [ion binding]; metal-binding site
635013005013	active site
635013005014	I-site; other site
635013005015	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
635013005016	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
635013005017	CPxP  motif; other site
635013005018	DsrE/DsrF-like family; Region: DrsE; cl00672
635013005019	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
635013005020	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
635013005021	G1 box; other site
635013005022	putative GEF interaction site [polypeptide binding]; other site
635013005023	GTP/Mg2+ binding site [chemical binding]; other site
635013005024	Switch I region; other site
635013005025	G2 box; other site
635013005026	G3 box; other site
635013005027	Switch II region; other site
635013005028	G4 box; other site
635013005029	G5 box; other site
635013005030	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
635013005031	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
635013005032	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
635013005033	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
635013005034	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
635013005035	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
635013005036	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
635013005037	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013005038	FeS/SAM binding site; other site
635013005039	NMT1-like family; Region: NMT1_2; cl15260
635013005040	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427
635013005041	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
635013005042	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013005043	FeS/SAM binding site; other site
635013005044	UbiA prenyltransferase family; Region: UbiA; cl00337
635013005045	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
635013005046	substrate binding pocket [chemical binding]; other site
635013005047	aspartate-rich region 1; other site
635013005048	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
635013005049	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013005050	S-adenosylmethionine binding site [chemical binding]; other site
635013005051	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
635013005052	Cysteine-rich domain; Region: CCG; pfam02754
635013005053	Cysteine-rich domain; Region: CCG; pfam02754
635013005054	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
635013005055	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
635013005056	Helix-turn-helix domains; Region: HTH; cl00088
635013005057	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
635013005058	homopentamer interface [polypeptide binding]; other site
635013005059	active site
635013005060	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
635013005061	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
635013005062	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
635013005063	dimerization interface [polypeptide binding]; other site
635013005064	active site
635013005065	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
635013005066	Lumazine binding domain; Region: Lum_binding; pfam00677
635013005067	Lumazine binding domain; Region: Lum_binding; pfam00677
635013005068	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
635013005069	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
635013005070	catalytic motif [active]
635013005071	Zn binding site [ion binding]; other site
635013005072	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
635013005073	Domain of unknown function (DUF378); Region: DUF378; cl00943
635013005074	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
635013005075	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
635013005076	substrate binding site [chemical binding]; other site
635013005077	hexamer interface [polypeptide binding]; other site
635013005078	metal binding site [ion binding]; metal-binding site
635013005079	GTPase RsgA; Reviewed; Region: PRK00098
635013005080	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
635013005081	RNA binding site [nucleotide binding]; other site
635013005082	homodimer interface [polypeptide binding]; other site
635013005083	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
635013005084	GTPase/Zn-binding domain interface [polypeptide binding]; other site
635013005085	GTP/Mg2+ binding site [chemical binding]; other site
635013005086	G4 box; other site
635013005087	G5 box; other site
635013005088	G1 box; other site
635013005089	Switch I region; other site
635013005090	G2 box; other site
635013005091	G3 box; other site
635013005092	Switch II region; other site
635013005093	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
635013005094	Catalytic domain of Protein Kinases; Region: PKc; cd00180
635013005095	active site
635013005096	ATP binding site [chemical binding]; other site
635013005097	substrate binding site [chemical binding]; other site
635013005098	activation loop (A-loop); other site
635013005099	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
635013005100	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
635013005101	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
635013005102	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
635013005103	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
635013005104	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013005105	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
635013005106	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
635013005107	Protein phosphatase 2C; Region: PP2C; pfam00481
635013005108	active site
635013005109	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
635013005110	phosphopeptide binding site; other site
635013005111	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
635013005112	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
635013005113	phosphopeptide binding site; other site
635013005114	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
635013005115	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013005116	FeS/SAM binding site; other site
635013005117	16S rRNA methyltransferase B; Provisional; Region: PRK14902
635013005118	N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620
635013005119	putative RNA binding site [nucleotide binding]; other site
635013005120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
635013005121	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
635013005122	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
635013005123	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
635013005124	putative active site [active]
635013005125	substrate binding site [chemical binding]; other site
635013005126	putative cosubstrate binding site; other site
635013005127	catalytic site [active]
635013005128	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
635013005129	substrate binding site [chemical binding]; other site
635013005130	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
635013005131	active site
635013005132	catalytic residues [active]
635013005133	metal binding site [ion binding]; metal-binding site
635013005134	primosome assembly protein PriA; Validated; Region: PRK05580
635013005135	primosome assembly protein PriA; Validated; Region: PRK05580
635013005136	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013005137	ATP binding site [chemical binding]; other site
635013005138	putative Mg++ binding site [ion binding]; other site
635013005139	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005140	Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262
635013005141	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
635013005142	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
635013005143	Protein export membrane protein; Region: SecD_SecF; cl14618
635013005144	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
635013005145	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013005146	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013005147	division inhibitor protein; Provisional; Region: slmA; PRK09480
635013005148	Helix-turn-helix domains; Region: HTH; cl00088
635013005149	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
635013005150	S-layer homology domain; Region: SLH; pfam00395
635013005151	S-layer homology domain; Region: SLH; pfam00395
635013005152	S-layer homology domain; Region: SLH; pfam00395
635013005153	S-adenosylmethionine synthetase; Validated; Region: PRK05250
635013005154	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
635013005155	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
635013005156	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
635013005157	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
635013005158	Flavoprotein; Region: Flavoprotein; cl08021
635013005159	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
635013005160	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
635013005161	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
635013005162	AAA domain; Region: AAA_18; pfam13238
635013005163	catalytic site [active]
635013005164	G-X2-G-X-G-K; other site
635013005165	Domain of unknown function (DUF370); Region: DUF370; cl00898
635013005166	hypothetical protein; Provisional; Region: PRK11820
635013005167	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
635013005168	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
635013005169	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
635013005170	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013005171	FeS/SAM binding site; other site
635013005172	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
635013005173	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
635013005174	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
635013005175	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013005176	homodimer interface [polypeptide binding]; other site
635013005177	catalytic residue [active]
635013005178	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
635013005179	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
635013005180	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
635013005181	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
635013005182	Domain of unknown function (DUF814); Region: DUF814; pfam05670
635013005183	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
635013005184	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
635013005185	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
635013005186	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
635013005187	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
635013005188	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
635013005189	4Fe-4S binding domain; Region: Fer4; cl02805
635013005190	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013005191	molybdopterin cofactor binding site; other site
635013005192	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013005193	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
635013005194	molybdopterin cofactor binding site; other site
635013005195	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013005196	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013005197	dimerization interface [polypeptide binding]; other site
635013005198	Helix-turn-helix domains; Region: HTH; cl00088
635013005199	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
635013005200	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
635013005201	G1 box; other site
635013005202	putative GEF interaction site [polypeptide binding]; other site
635013005203	GTP/Mg2+ binding site [chemical binding]; other site
635013005204	Switch I region; other site
635013005205	G2 box; other site
635013005206	G3 box; other site
635013005207	Switch II region; other site
635013005208	G4 box; other site
635013005209	G5 box; other site
635013005210	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
635013005211	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
635013005212	Protein of unknown function (DUF523); Region: DUF523; cl00733
635013005213	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
635013005214	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
635013005215	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013005216	active site
635013005217	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
635013005218	active site
635013005219	dimer interface [polypeptide binding]; other site
635013005220	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
635013005221	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
635013005222	heterodimer interface [polypeptide binding]; other site
635013005223	active site
635013005224	FMN binding site [chemical binding]; other site
635013005225	homodimer interface [polypeptide binding]; other site
635013005226	substrate binding site [chemical binding]; other site
635013005227	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
635013005228	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
635013005229	FAD binding pocket [chemical binding]; other site
635013005230	FAD binding motif [chemical binding]; other site
635013005231	phosphate binding motif [ion binding]; other site
635013005232	beta-alpha-beta structure motif; other site
635013005233	NAD binding pocket [chemical binding]; other site
635013005234	Iron coordination center [ion binding]; other site
635013005235	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
635013005236	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
635013005237	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013005238	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
635013005239	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
635013005240	ATP-grasp domain; Region: ATP-grasp_4; cl03087
635013005241	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
635013005242	IMP binding site; other site
635013005243	dimer interface [polypeptide binding]; other site
635013005244	interdomain contacts; other site
635013005245	partial ornithine binding site; other site
635013005246	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
635013005247	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
635013005248	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
635013005249	catalytic site [active]
635013005250	subunit interface [polypeptide binding]; other site
635013005251	dihydroorotase; Validated; Region: pyrC; PRK09357
635013005252	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
635013005253	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
635013005254	active site
635013005255	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
635013005256	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
635013005257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013005258	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013005259	active site
635013005260	Restriction endonuclease; Region: Mrr_cat; cl00516
635013005261	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
635013005262	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
635013005263	RNA binding surface [nucleotide binding]; other site
635013005264	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
635013005265	active site
635013005266	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
635013005267	lipoprotein signal peptidase; Provisional; Region: PRK14787
635013005268	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
635013005269	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
635013005270	FMN binding site [chemical binding]; other site
635013005271	dimer interface [polypeptide binding]; other site
635013005272	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
635013005273	Uncharacterized conserved protein [Function unknown]; Region: COG2966
635013005274	Protein of unknown function (DUF1212); Region: DUF1212; cl01118
635013005275	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013005276	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013005277	SdiA-regulated; Region: SdiA-regulated; cd09971
635013005278	NHL repeat; Region: NHL; pfam01436
635013005279	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
635013005280	NHL repeat; Region: NHL; pfam01436
635013005281	TPR repeat; Region: TPR_11; pfam13414
635013005282	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005283	binding surface
635013005284	TPR motif; other site
635013005285	TPR repeat; Region: TPR_11; pfam13414
635013005286	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005287	TPR repeat; Region: TPR_11; pfam13414
635013005288	binding surface
635013005289	TPR motif; other site
635013005290	cytochrome c nitrate reductase, small subunit; Region: cytochr_NrfH; TIGR03153
635013005291	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
635013005292	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013005293	active site
635013005294	phosphorylation site [posttranslational modification]
635013005295	intermolecular recognition site; other site
635013005296	dimerization interface [polypeptide binding]; other site
635013005297	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
635013005298	DNA binding residues [nucleotide binding]
635013005299	dimerization interface [polypeptide binding]; other site
635013005300	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
635013005301	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
635013005302	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
635013005303	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
635013005304	Coenzyme A binding pocket [chemical binding]; other site
635013005305	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
635013005306	anti sigma factor interaction site; other site
635013005307	regulatory phosphorylation site [posttranslational modification]; other site
635013005308	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
635013005309	Protein of unknown function (DUF342); Region: DUF342; pfam03961
635013005310	Protein of unknown function (DUF342); Region: DUF342; pfam03961
635013005311	Urea transporter; Region: UT; cl01829
635013005312	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013005313	Zn2+ binding site [ion binding]; other site
635013005314	Mg2+ binding site [ion binding]; other site
635013005315	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
635013005316	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
635013005317	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
635013005318	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
635013005319	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
635013005320	HIGH motif; other site
635013005321	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
635013005322	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
635013005323	active site
635013005324	KMSKS motif; other site
635013005325	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
635013005326	tRNA binding surface [nucleotide binding]; other site
635013005327	anticodon binding site; other site
635013005328	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
635013005329	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
635013005330	DivIVA protein; Region: DivIVA; pfam05103
635013005331	DivIVA domain; Region: DivI1A_domain; TIGR03544
635013005332	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
635013005333	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
635013005334	active site
635013005335	HIGH motif; other site
635013005336	dimer interface [polypeptide binding]; other site
635013005337	KMSKS motif; other site
635013005338	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
635013005339	RNA binding surface [nucleotide binding]; other site
635013005340	Transglycosylase; Region: Transgly; cl07896
635013005341	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
635013005342	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013005343	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
635013005344	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
635013005345	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
635013005346	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
635013005347	Walker A/P-loop; other site
635013005348	ATP binding site [chemical binding]; other site
635013005349	Q-loop/lid; other site
635013005350	ABC transporter signature motif; other site
635013005351	Walker B; other site
635013005352	D-loop; other site
635013005353	H-loop/switch region; other site
635013005354	Plant ATP synthase F0; Region: YMF19; cl07975
635013005355	Smr domain; Region: Smr; cl02619
635013005356	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
635013005357	Peptidase family U32; Region: Peptidase_U32; cl03113
635013005358	Collagenase; Region: DUF3656; pfam12392
635013005359	Peptidase family U32; Region: Peptidase_U32; cl03113
635013005360	Uncharacterized conserved protein [Function unknown]; Region: COG0327
635013005361	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
635013005362	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
635013005363	hypothetical protein; Provisional; Region: PRK08609
635013005364	active site
635013005365	primer binding site [nucleotide binding]; other site
635013005366	NTP  binding site [chemical binding]; other site
635013005367	metal binding triad [ion binding]; metal-binding site
635013005368	Cell division protein ZapA; Region: ZapA; cl01146
635013005369	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
635013005370	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
635013005371	putative tRNA-binding site [nucleotide binding]; other site
635013005372	B3/4 domain; Region: B3_4; cl11458
635013005373	tRNA synthetase B5 domain; Region: B5; cl08394
635013005374	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
635013005375	dimer interface [polypeptide binding]; other site
635013005376	motif 1; other site
635013005377	motif 3; other site
635013005378	motif 2; other site
635013005379	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
635013005380	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
635013005381	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
635013005382	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
635013005383	dimer interface [polypeptide binding]; other site
635013005384	motif 1; other site
635013005385	active site
635013005386	motif 2; other site
635013005387	motif 3; other site
635013005388	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
635013005389	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
635013005390	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
635013005391	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
635013005392	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013005393	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
635013005394	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
635013005395	Cation transport protein; Region: TrkH; cl10514
635013005396	ribosomal protein L20; Region: rpl20; CHL00068
635013005397	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
635013005398	23S rRNA binding site [nucleotide binding]; other site
635013005399	L21 binding site [polypeptide binding]; other site
635013005400	L13 binding site [polypeptide binding]; other site
635013005401	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
635013005402	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
635013005403	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
635013005404	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
635013005405	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
635013005406	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
635013005407	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
635013005408	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
635013005409	active site
635013005410	dimer interface [polypeptide binding]; other site
635013005411	motif 1; other site
635013005412	motif 2; other site
635013005413	motif 3; other site
635013005414	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
635013005415	anticodon binding site; other site
635013005416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
635013005417	YtxC-like family; Region: YtxC; cl08500
635013005418	Integrase core domain; Region: rve; cl01316
635013005419	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
635013005420	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
635013005421	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013005422	Walker A motif; other site
635013005423	ATP binding site [chemical binding]; other site
635013005424	Walker B motif; other site
635013005425	arginine finger; other site
635013005426	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
635013005427	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
635013005428	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
635013005429	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
635013005430	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
635013005431	CRISPR-associated protein Cas8c/Csd1, subtype I-C/DVULG; Region: cas_Csd1; TIGR01863
635013005432	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
635013005433	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
635013005434	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
635013005435	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005436	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
635013005437	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
635013005438	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
635013005439	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013005440	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
635013005441	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
635013005442	putative protease; Provisional; Region: PRK15452
635013005443	Peptidase family U32; Region: Peptidase_U32; cl03113
635013005444	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
635013005445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013005446	S-adenosylmethionine binding site [chemical binding]; other site
635013005447	YceG-like family; Region: YceG; pfam02618
635013005448	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
635013005449	dimerization interface [polypeptide binding]; other site
635013005450	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
635013005451	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005452	G4 box; other site
635013005453	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
635013005454	VanW like protein; Region: VanW; pfam04294
635013005455	G5 domain; Region: G5; pfam07501
635013005456	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
635013005457	Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667
635013005458	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
635013005459	active site
635013005460	catalytic tetrad [active]
635013005461	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013005462	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013005463	Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857
635013005464	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
635013005465	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
635013005466	motif 1; other site
635013005467	active site
635013005468	motif 2; other site
635013005469	motif 3; other site
635013005470	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
635013005471	DHHA1 domain; Region: DHHA1; pfam02272
635013005472	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
635013005473	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013005474	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013005475	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
635013005476	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
635013005477	Ligand Binding Site [chemical binding]; other site
635013005478	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
635013005479	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
635013005480	trimerization site [polypeptide binding]; other site
635013005481	active site
635013005482	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
635013005483	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
635013005484	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
635013005485	catalytic residue [active]
635013005486	Helix-turn-helix domains; Region: HTH; cl00088
635013005487	Rrf2 family protein; Region: rrf2_super; TIGR00738
635013005488	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
635013005489	recombination factor protein RarA; Reviewed; Region: PRK13342
635013005490	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013005491	Walker A motif; other site
635013005492	ATP binding site [chemical binding]; other site
635013005493	Walker B motif; other site
635013005494	arginine finger; other site
635013005495	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
635013005496	acetyl-CoA synthetase; Provisional; Region: PRK04319
635013005497	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
635013005498	AMP-binding enzyme; Region: AMP-binding; cl15778
635013005499	AMP-binding enzyme; Region: AMP-binding; cl15778
635013005500	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
635013005501	ferric uptake regulator; Provisional; Region: fur; PRK09462
635013005502	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
635013005503	metal binding site 2 [ion binding]; metal-binding site
635013005504	putative DNA binding helix; other site
635013005505	metal binding site 1 [ion binding]; metal-binding site
635013005506	dimer interface [polypeptide binding]; other site
635013005507	structural Zn2+ binding site [ion binding]; other site
635013005508	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
635013005509	catalytic residues [active]
635013005510	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
635013005511	putative homotetramer interface [polypeptide binding]; other site
635013005512	putative homodimer interface [polypeptide binding]; other site
635013005513	putative allosteric switch controlling residues; other site
635013005514	putative metal binding site [ion binding]; other site
635013005515	putative homodimer-homodimer interface [polypeptide binding]; other site
635013005516	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
635013005517	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
635013005518	putative ATP binding site [chemical binding]; other site
635013005519	putative substrate interface [chemical binding]; other site
635013005520	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
635013005521	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
635013005522	dimer interface [polypeptide binding]; other site
635013005523	anticodon binding site; other site
635013005524	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
635013005525	homodimer interface [polypeptide binding]; other site
635013005526	motif 1; other site
635013005527	active site
635013005528	motif 2; other site
635013005529	GAD domain; Region: GAD; pfam02938
635013005530	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
635013005531	motif 3; other site
635013005532	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
635013005533	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
635013005534	dimer interface [polypeptide binding]; other site
635013005535	motif 1; other site
635013005536	active site
635013005537	motif 2; other site
635013005538	motif 3; other site
635013005539	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
635013005540	anticodon binding site; other site
635013005541	coproporphyrinogen III oxidase; Provisional; Region: PRK08207
635013005542	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013005543	FeS/SAM binding site; other site
635013005544	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
635013005545	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
635013005546	stage V sporulation protein B; Region: spore_V_B; TIGR02900
635013005547	MatE; Region: MatE; cl10513
635013005548	MatE; Region: MatE; cl10513
635013005549	Survival protein SurE; Region: SurE; cl00448
635013005550	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
635013005551	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
635013005552	homodecamer interface [polypeptide binding]; other site
635013005553	GTP cyclohydrolase I; Provisional; Region: PLN03044
635013005554	active site
635013005555	putative catalytic site residues [active]
635013005556	zinc binding site [ion binding]; other site
635013005557	GTP-CH-I/GFRP interaction surface; other site
635013005558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
635013005559	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
635013005560	Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain [Signal transduction mechanisms]; Region: COG5001
635013005561	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013005562	metal binding site [ion binding]; metal-binding site
635013005563	active site
635013005564	I-site; other site
635013005565	TPR repeat; Region: TPR_11; pfam13414
635013005566	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005567	binding surface
635013005568	TPR motif; other site
635013005569	TPR repeat; Region: TPR_11; pfam13414
635013005570	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005571	binding surface
635013005572	TPR motif; other site
635013005573	TPR repeat; Region: TPR_11; pfam13414
635013005574	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005575	binding surface
635013005576	TPR motif; other site
635013005577	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005578	binding surface
635013005579	TPR motif; other site
635013005580	TPR repeat; Region: TPR_11; pfam13414
635013005581	TPR repeat; Region: TPR_11; pfam13414
635013005582	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005583	binding surface
635013005584	TPR motif; other site
635013005585	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
635013005586	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013005587	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
635013005588	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
635013005589	ACS interaction site; other site
635013005590	CODH interaction site; other site
635013005591	cubane metal cluster (B-cluster) [ion binding]; other site
635013005592	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
635013005593	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
635013005594	4Fe-4S binding domain; Region: Fer4; cl02805
635013005595	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005596	binding surface
635013005597	TPR motif; other site
635013005598	TPR repeat; Region: TPR_11; pfam13414
635013005599	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005600	binding surface
635013005601	TPR motif; other site
635013005602	TPR repeat; Region: TPR_11; pfam13414
635013005603	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005604	binding surface
635013005605	TPR motif; other site
635013005606	TPR repeat; Region: TPR_11; pfam13414
635013005607	TPR repeat; Region: TPR_11; pfam13414
635013005608	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005609	binding surface
635013005610	TPR motif; other site
635013005611	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
635013005612	ABC-2 type transporter; Region: ABC2_membrane; cl11417
635013005613	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
635013005614	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005615	Walker A/P-loop; other site
635013005616	ATP binding site [chemical binding]; other site
635013005617	Q-loop/lid; other site
635013005618	ABC transporter signature motif; other site
635013005619	Walker B; other site
635013005620	D-loop; other site
635013005621	H-loop/switch region; other site
635013005622	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
635013005623	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013005624	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013005625	ABC-2 type transporter; Region: ABC2_membrane; cl11417
635013005626	DrrA is the ATP-binding protein component of a bacterial exporter complex that confers resistance to the antibiotics daunorubicin and doxorubicin.  In addition to DrrA, the complex includes an integral membrane protein called DrrB.  DrrA belongs to the...; Region: ABC_DrrA; cd03265
635013005627	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
635013005628	Walker A/P-loop; other site
635013005629	ATP binding site [chemical binding]; other site
635013005630	Q-loop/lid; other site
635013005631	ABC transporter signature motif; other site
635013005632	Walker B; other site
635013005633	D-loop; other site
635013005634	H-loop/switch region; other site
635013005635	Protein of unknown function (DUF3792); Region: DUF3792; cl14821
635013005636	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
635013005637	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013005638	putative active site [active]
635013005639	heme pocket [chemical binding]; other site
635013005640	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013005641	dimer interface [polypeptide binding]; other site
635013005642	phosphorylation site [posttranslational modification]
635013005643	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013005644	ATP binding site [chemical binding]; other site
635013005645	Mg2+ binding site [ion binding]; other site
635013005646	G-X-G motif; other site
635013005647	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
635013005648	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
635013005649	FAD binding pocket [chemical binding]; other site
635013005650	FAD binding motif [chemical binding]; other site
635013005651	phosphate binding motif [ion binding]; other site
635013005652	beta-alpha-beta structure motif; other site
635013005653	NAD binding pocket [chemical binding]; other site
635013005654	Iron coordination center [ion binding]; other site
635013005655	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
635013005656	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013005657	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
635013005658	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
635013005659	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
635013005660	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
635013005661	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
635013005662	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
635013005663	Cysteine-rich domain; Region: CCG; pfam02754
635013005664	Cysteine-rich domain; Region: CCG; pfam02754
635013005665	Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150
635013005666	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
635013005667	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
635013005668	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
635013005669	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
635013005670	active site
635013005671	substrate binding site [chemical binding]; other site
635013005672	catalytic site [active]
635013005673	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005674	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005675	putative Mg++ binding site [ion binding]; other site
635013005676	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005677	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
635013005678	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
635013005679	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
635013005680	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013005681	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
635013005682	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
635013005683	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
635013005684	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013005685	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
635013005686	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
635013005687	ligand binding site [chemical binding]; other site
635013005688	flexible hinge region; other site
635013005689	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
635013005690	putative switch regulator; other site
635013005691	non-specific DNA interactions [nucleotide binding]; other site
635013005692	DNA binding site [nucleotide binding]
635013005693	sequence specific DNA binding site [nucleotide binding]; other site
635013005694	putative cAMP binding site [chemical binding]; other site
635013005695	MTH865-like family; Region: MTH865; cl01962
635013005696	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
635013005697	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
635013005698	Int/Topo IB signature motif; other site
635013005699	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013005700	Restriction endonuclease; Region: Mrr_cat; cl00516
635013005701	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013005702	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
635013005703	active site
635013005704	ATP binding site [chemical binding]; other site
635013005705	substrate binding site [chemical binding]; other site
635013005706	activation loop (A-loop); other site
635013005707	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
635013005708	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
635013005709	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
635013005710	minor groove reading motif; other site
635013005711	helix-hairpin-helix signature motif; other site
635013005712	substrate binding pocket [chemical binding]; other site
635013005713	active site
635013005714	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
635013005715	Helix-turn-helix domains; Region: HTH; cl00088
635013005716	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
635013005717	putative dimerization interface [polypeptide binding]; other site
635013005718	adenylate kinase; Reviewed; Region: adk; PRK00279
635013005719	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
635013005720	AMP-binding site [chemical binding]; other site
635013005721	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
635013005722	Flavin Reductases; Region: FlaRed; cl00801
635013005723	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
635013005724	Rubredoxin; Region: Rubredoxin; pfam00301
635013005725	iron binding site [ion binding]; other site
635013005726	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
635013005727	Uncharacterized conserved protein [Function unknown]; Region: COG4717
635013005728	Uncharacterized conserved protein [Function unknown]; Region: COG4717
635013005729	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005730	ABC transporter signature motif; other site
635013005731	Walker B; other site
635013005732	D-loop; other site
635013005733	H-loop/switch region; other site
635013005734	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
635013005735	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
635013005736	active site
635013005737	metal binding site [ion binding]; metal-binding site
635013005738	DNA binding site [nucleotide binding]
635013005739	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
635013005740	SpoVR like protein; Region: SpoVR; pfam04293
635013005741	Uncharacterized conserved protein [Function unknown]; Region: COG2718
635013005742	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
635013005743	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
635013005744	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
635013005745	HEPN domain; Region: HEPN; cl00824
635013005746	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
635013005747	active site
635013005748	NTP binding site [chemical binding]; other site
635013005749	metal binding triad [ion binding]; metal-binding site
635013005750	Transposase, Mutator family; Region: Transposase_mut; pfam00872
635013005751	MULE transposase domain; Region: MULE; pfam10551
635013005752	Integrase core domain; Region: rve; cl01316
635013005753	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
635013005754	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
635013005755	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013005756	Walker A motif; other site
635013005757	ATP binding site [chemical binding]; other site
635013005758	Walker B motif; other site
635013005759	arginine finger; other site
635013005760	TIR domain; Region: TIR_2; cl15770
635013005761	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
635013005762	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is inactive in...; Region: YhaM_OBF_like; cd04492
635013005763	generic binding surface II; other site
635013005764	generic binding surface I; other site
635013005765	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
635013005766	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013005767	Zn2+ binding site [ion binding]; other site
635013005768	Mg2+ binding site [ion binding]; other site
635013005769	S-layer homology domain; Region: SLH; pfam00395
635013005770	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
635013005771	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
635013005772	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
635013005773	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
635013005774	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
635013005775	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
635013005776	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
635013005777	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
635013005778	CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578
635013005779	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
635013005780	spermidine synthase; Provisional; Region: PRK00811
635013005781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013005782	S-adenosylmethionine binding site [chemical binding]; other site
635013005783	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
635013005784	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013005785	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013005786	Walker A motif; other site
635013005787	ATP binding site [chemical binding]; other site
635013005788	Walker B motif; other site
635013005789	arginine finger; other site
635013005790	Helix-turn-helix domains; Region: HTH; cl00088
635013005791	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
635013005792	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
635013005793	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005794	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
635013005795	Restriction endonuclease; Region: Mrr_cat; cl00516
635013005796	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
635013005797	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
635013005798	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
635013005799	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
635013005800	NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590
635013005801	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
635013005802	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
635013005803	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
635013005804	NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634
635013005805	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
635013005806	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013005807	NADH dehydrogenase; Region: NADHdh; cl00469
635013005808	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
635013005809	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
635013005810	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
635013005811	NADH dehydrogenase subunit B; Validated; Region: PRK06411
635013005812	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
635013005813	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535
635013005814	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
635013005815	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013005816	Zn2+ binding site [ion binding]; other site
635013005817	Mg2+ binding site [ion binding]; other site
635013005818	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
635013005819	RNA/DNA hybrid binding site [nucleotide binding]; other site
635013005820	active site
635013005821	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
635013005822	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
635013005823	GTP/Mg2+ binding site [chemical binding]; other site
635013005824	G4 box; other site
635013005825	G5 box; other site
635013005826	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013005827	G1 box; other site
635013005828	Switch I region; other site
635013005829	G2 box; other site
635013005830	G3 box; other site
635013005831	Switch II region; other site
635013005832	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
635013005833	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
635013005834	Catalytic site [active]
635013005835	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
635013005836	Transposase domain (DUF772); Region: DUF772; cl15789
635013005837	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013005838	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
635013005839	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
635013005840	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
635013005841	RimM N-terminal domain; Region: RimM; pfam01782
635013005842	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013005843	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
635013005844	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
635013005845	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
635013005846	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
635013005847	signal recognition particle protein; Provisional; Region: PRK10867
635013005848	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
635013005849	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
635013005850	P loop; other site
635013005851	GTP binding site [chemical binding]; other site
635013005852	Signal peptide binding domain; Region: SRP_SPB; pfam02978
635013005853	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
635013005854	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
635013005855	Phosphate transporter family; Region: PHO4; cl00396
635013005856	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
635013005857	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
635013005858	active site
635013005859	putative substrate binding pocket [chemical binding]; other site
635013005860	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
635013005861	intersubunit interface [polypeptide binding]; other site
635013005862	active site
635013005863	Zn2+ binding site [ion binding]; other site
635013005864	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
635013005865	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013005866	oligomerization interface [polypeptide binding]; other site
635013005867	active site
635013005868	NAD+ binding site [chemical binding]; other site
635013005869	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
635013005870	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
635013005871	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
635013005872	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
635013005873	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
635013005874	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
635013005875	P loop; other site
635013005876	GTP binding site [chemical binding]; other site
635013005877	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
635013005878	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
635013005879	Walker A/P-loop; other site
635013005880	ATP binding site [chemical binding]; other site
635013005881	Q-loop/lid; other site
635013005882	Septum formation initiator; Region: DivIC; cl11433
635013005883	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
635013005884	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
635013005885	Q-loop/lid; other site
635013005886	ABC transporter signature motif; other site
635013005887	Walker B; other site
635013005888	D-loop; other site
635013005889	H-loop/switch region; other site
635013005890	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
635013005891	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013005892	metal binding site [ion binding]; metal-binding site
635013005893	active site
635013005894	I-site; other site
635013005895	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
635013005896	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
635013005897	active site pocket [active]
635013005898	putative dimer interface [polypeptide binding]; other site
635013005899	putative cataytic base [active]
635013005900	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
635013005901	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013005902	S-adenosylmethionine binding site [chemical binding]; other site
635013005903	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013005904	Radical SAM superfamily; Region: Radical_SAM; pfam04055
635013005905	FeS/SAM binding site; other site
635013005906	ribonuclease III; Reviewed; Region: rnc; PRK00102
635013005907	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
635013005908	dimerization interface [polypeptide binding]; other site
635013005909	active site
635013005910	metal binding site [ion binding]; metal-binding site
635013005911	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
635013005912	dsRNA binding site [nucleotide binding]; other site
635013005913	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
635013005914	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
635013005915	dimer interface [polypeptide binding]; other site
635013005916	active site
635013005917	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
635013005918	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
635013005919	FMN binding site [chemical binding]; other site
635013005920	substrate binding site [chemical binding]; other site
635013005921	putative catalytic residue [active]
635013005922	Phosphopantetheine attachment site; Region: PP-binding; cl09936
635013005923	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
635013005924	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
635013005925	NAD(P) binding site [chemical binding]; other site
635013005926	homotetramer interface [polypeptide binding]; other site
635013005927	homodimer interface [polypeptide binding]; other site
635013005928	active site
635013005929	Acyl transferase domain; Region: Acyl_transf_1; cl08282
635013005930	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
635013005931	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
635013005932	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
635013005933	FMN binding site [chemical binding]; other site
635013005934	substrate binding site [chemical binding]; other site
635013005935	putative catalytic residue [active]
635013005936	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
635013005937	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
635013005938	dimer interface [polypeptide binding]; other site
635013005939	active site
635013005940	CoA binding pocket [chemical binding]; other site
635013005941	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
635013005942	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
635013005943	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
635013005944	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
635013005945	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
635013005946	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
635013005947	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
635013005948	hypothetical protein; Provisional; Region: PRK13670
635013005949	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
635013005950	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
635013005951	Nucleoside recognition; Region: Gate; cl00486
635013005952	Nucleoside recognition; Region: Gate; cl00486
635013005953	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
635013005954	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
635013005955	active site
635013005956	(T/H)XGH motif; other site
635013005957	Methyltransferase domain; Region: Methyltransf_31; pfam13847
635013005958	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013005959	S-adenosylmethionine binding site [chemical binding]; other site
635013005960	Transposase domain (DUF772); Region: DUF772; cl15789
635013005961	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013005962	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
635013005963	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
635013005964	putative homodimer interface [polypeptide binding]; other site
635013005965	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
635013005966	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013005967	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
635013005968	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013005969	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
635013005970	Germination protease; Region: Peptidase_A25; cl04057
635013005971	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
635013005972	NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034
635013005973	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013005974	catalytic loop [active]
635013005975	iron binding site [ion binding]; other site
635013005976	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
635013005977	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
635013005978	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
635013005979	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
635013005980	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013005981	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
635013005982	NHL repeat; Region: NHL; pfam01436
635013005983	TPR repeat; Region: TPR_11; pfam13414
635013005984	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013005985	binding surface
635013005986	TPR motif; other site
635013005987	TPR repeat; Region: TPR_11; pfam13414
635013005988	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
635013005989	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
635013005990	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
635013005991	generic binding surface II; other site
635013005992	ssDNA binding site; other site
635013005993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013005994	ATP binding site [chemical binding]; other site
635013005995	putative Mg++ binding site [ion binding]; other site
635013005996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013005997	nucleotide binding region [chemical binding]; other site
635013005998	ATP-binding site [chemical binding]; other site
635013005999	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
635013006000	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
635013006001	DAK2 domain; Region: Dak2; cl03685
635013006002	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
635013006003	Asp23 family; Region: Asp23; cl00574
635013006004	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
635013006005	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
635013006006	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
635013006007	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
635013006008	dimerization interface [polypeptide binding]; other site
635013006009	domain crossover interface; other site
635013006010	redox-dependent activation switch; other site
635013006011	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
635013006012	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
635013006013	active site
635013006014	metal binding site [ion binding]; metal-binding site
635013006015	homotetramer interface [polypeptide binding]; other site
635013006016	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
635013006017	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
635013006018	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
635013006019	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
635013006020	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
635013006021	HDOD domain; Region: HDOD; pfam08668
635013006022	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013006023	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013006024	Zn2+ binding site [ion binding]; other site
635013006025	Mg2+ binding site [ion binding]; other site
635013006026	homoserine kinase; Provisional; Region: PRK01212
635013006027	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
635013006028	homoserine dehydrogenase; Provisional; Region: PRK06349
635013006029	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006030	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
635013006031	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
635013006032	hypothetical protein; Provisional; Region: PRK04435
635013006033	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
635013006034	Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221
635013006035	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
635013006036	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
635013006037	tRNA-N(6)-(isopentenyl)adenosine-37 thiotransferase enzyme MiaB; Region: miaB-methiolase; TIGR01574
635013006038	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
635013006039	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
635013006040	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
635013006041	RNA binding surface [nucleotide binding]; other site
635013006042	YGGT family; Region: YGGT; cl00508
635013006043	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
635013006044	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006045	Protein of unknown function (DUF552); Region: DUF552; cl00775
635013006046	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
635013006047	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
635013006048	catalytic residue [active]
635013006049	HlyD family secretion protein; Region: HlyD_2; pfam12700
635013006050	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013006051	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
635013006052	PhoU domain; Region: PhoU; pfam01895
635013006053	PhoU domain; Region: PhoU; pfam01895
635013006054	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
635013006055	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
635013006056	Walker A/P-loop; other site
635013006057	ATP binding site [chemical binding]; other site
635013006058	Q-loop/lid; other site
635013006059	ABC transporter signature motif; other site
635013006060	Walker B; other site
635013006061	D-loop; other site
635013006062	H-loop/switch region; other site
635013006063	methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048
635013006064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013006065	dimerization interface [polypeptide binding]; other site
635013006066	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
635013006067	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013006068	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013006069	dimer interface [polypeptide binding]; other site
635013006070	phosphorylation site [posttranslational modification]
635013006071	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013006072	ATP binding site [chemical binding]; other site
635013006073	Mg2+ binding site [ion binding]; other site
635013006074	G-X-G motif; other site
635013006075	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
635013006076	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013006077	active site
635013006078	phosphorylation site [posttranslational modification]
635013006079	intermolecular recognition site; other site
635013006080	dimerization interface [polypeptide binding]; other site
635013006081	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013006082	DNA binding site [nucleotide binding]
635013006083	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
635013006084	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
635013006085	autolysin; Reviewed; Region: PRK06347
635013006086	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013006087	putative peptidoglycan binding site; other site
635013006088	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107
635013006089	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
635013006090	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
635013006091	putative dimer interface [polypeptide binding]; other site
635013006092	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013006093	putative peptidoglycan binding site; other site
635013006094	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
635013006095	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013006096	putative peptidoglycan binding site; other site
635013006097	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
635013006098	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
635013006099	thiS-thiF/thiG interaction site; other site
635013006100	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
635013006101	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
635013006102	ATP cone domain; Region: ATP-cone; pfam03477
635013006103	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704
635013006104	Class III ribonucleotide reductase; Region: RNR_III; cd01675
635013006105	effector binding site; other site
635013006106	active site
635013006107	Zn binding site [ion binding]; other site
635013006108	glycine loop; other site
635013006109	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
635013006110	ATP cone domain; Region: ATP-cone; pfam03477
635013006111	hypothetical protein; Provisional; Region: PRK03636
635013006112	UPF0302 domain; Region: UPF0302; pfam08864
635013006113	IDEAL domain; Region: IDEAL; cl07452
635013006114	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
635013006115	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
635013006116	ACS interaction site; other site
635013006117	CODH interaction site; other site
635013006118	cubane metal cluster (B-cluster) [ion binding]; other site
635013006119	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
635013006120	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013006121	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
635013006122	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
635013006123	active site
635013006124	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775
635013006125	sporulation sigma factor SigG; Reviewed; Region: PRK08215
635013006126	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013006127	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
635013006128	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013006129	DNA binding residues [nucleotide binding]
635013006130	sporulation sigma factor SigE; Reviewed; Region: PRK08301
635013006131	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013006132	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013006133	DNA binding residues [nucleotide binding]
635013006134	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
635013006135	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
635013006136	Putative zinc-finger; Region: zf-HC2; cl15806
635013006137	cell division protein FtsZ; Validated; Region: PRK09330
635013006138	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
635013006139	nucleotide binding site [chemical binding]; other site
635013006140	SulA interaction site; other site
635013006141	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
635013006142	Cell division protein FtsA; Region: FtsA; cl11496
635013006143	Cell division protein FtsA; Region: FtsA; cl11496
635013006144	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
635013006145	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
635013006146	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
635013006147	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
635013006148	Cell division protein FtsQ; Region: FtsQ; pfam03799
635013006149	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
635013006150	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
635013006151	hinge; other site
635013006152	active site
635013006153	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
635013006154	FAD binding domain; Region: FAD_binding_4; pfam01565
635013006155	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
635013006156	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
635013006157	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
635013006158	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
635013006159	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
635013006160	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
635013006161	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
635013006162	active site
635013006163	homodimer interface [polypeptide binding]; other site
635013006164	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
635013006165	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
635013006166	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006167	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
635013006168	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
635013006169	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
635013006170	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
635013006171	Mg++ binding site [ion binding]; other site
635013006172	putative catalytic motif [active]
635013006173	putative substrate binding site [chemical binding]; other site
635013006174	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
635013006175	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
635013006176	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
635013006177	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
635013006178	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
635013006179	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
635013006180	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
635013006181	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
635013006182	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
635013006183	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
635013006184	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013006185	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
635013006186	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
635013006187	Septum formation initiator; Region: DivIC; cl11433
635013006188	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
635013006189	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006190	cell division protein MraZ; Reviewed; Region: PRK00326
635013006191	MraZ protein; Region: MraZ; pfam02381
635013006192	MraZ protein; Region: MraZ; pfam02381
635013006193	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
635013006194	histidinol-phosphatase; Provisional; Region: PRK07328
635013006195	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
635013006196	metal ion-dependent adhesion site (MIDAS); other site
635013006197	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
635013006198	Transposase domain (DUF772); Region: DUF772; cl15789
635013006199	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013006200	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
635013006201	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
635013006202	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
635013006203	active site
635013006204	dimer interface [polypeptide binding]; other site
635013006205	Sugar fermentation stimulation protein; Region: SfsA; cl00647
635013006206	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
635013006207	putative active site [active]
635013006208	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
635013006209	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
635013006210	active site
635013006211	Substrate binding site; other site
635013006212	Mg++ binding site; other site
635013006213	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
635013006214	putative trimer interface [polypeptide binding]; other site
635013006215	putative CoA binding site [chemical binding]; other site
635013006216	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
635013006217	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
635013006218	active site
635013006219	substrate binding site [chemical binding]; other site
635013006220	metal binding site [ion binding]; metal-binding site
635013006221	Uncharacterized conserved protein [Function unknown]; Region: COG1543
635013006222	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
635013006223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
635013006224	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
635013006225	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
635013006226	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
635013006227	active site
635013006228	nucleophile elbow; other site
635013006229	LysE type translocator; Region: LysE; cl00565
635013006230	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
635013006231	active site clefts [active]
635013006232	zinc binding site [ion binding]; other site
635013006233	dimer interface [polypeptide binding]; other site
635013006234	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
635013006235	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
635013006236	FtsX-like permease family; Region: FtsX; cl15850
635013006237	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
635013006238	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
635013006239	Walker A/P-loop; other site
635013006240	ATP binding site [chemical binding]; other site
635013006241	Q-loop/lid; other site
635013006242	ABC transporter signature motif; other site
635013006243	Walker B; other site
635013006244	D-loop; other site
635013006245	H-loop/switch region; other site
635013006246	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
635013006247	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
635013006248	FtsX-like permease family; Region: FtsX; cl15850
635013006249	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
635013006250	Peptidase family M48; Region: Peptidase_M48; cl12018
635013006251	Helix-turn-helix domains; Region: HTH; cl00088
635013006252	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
635013006253	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
635013006254	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
635013006255	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
635013006256	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013006257	dimerization interface [polypeptide binding]; other site
635013006258	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013006259	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013006260	dimer interface [polypeptide binding]; other site
635013006261	putative CheW interface [polypeptide binding]; other site
635013006262	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
635013006263	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013006264	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013006265	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
635013006266	S-layer homology domain; Region: SLH; pfam00395
635013006267	S-layer homology domain; Region: SLH; pfam00395
635013006268	S-layer homology domain; Region: SLH; pfam00395
635013006269	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
635013006270	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
635013006271	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
635013006272	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
635013006273	P-loop; other site
635013006274	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013006275	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
635013006276	active site
635013006277	metal binding site [ion binding]; metal-binding site
635013006278	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
635013006279	elongation factor G; Reviewed; Region: PRK12740
635013006280	G1 box; other site
635013006281	putative GEF interaction site [polypeptide binding]; other site
635013006282	GTP/Mg2+ binding site [chemical binding]; other site
635013006283	Switch I region; other site
635013006284	G2 box; other site
635013006285	G3 box; other site
635013006286	Switch II region; other site
635013006287	G4 box; other site
635013006288	G5 box; other site
635013006289	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
635013006290	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
635013006291	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
635013006292	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
635013006293	catalytic residues [active]
635013006294	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
635013006295	active site residue [active]
635013006296	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
635013006297	active site residue [active]
635013006298	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
635013006299	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013006300	dimerization interface [polypeptide binding]; other site
635013006301	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
635013006302	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013006303	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013006304	dimer interface [polypeptide binding]; other site
635013006305	putative CheW interface [polypeptide binding]; other site
635013006306	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006307	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
635013006308	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
635013006309	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
635013006310	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
635013006311	DNA binding residues [nucleotide binding]
635013006312	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
635013006313	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013006314	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
635013006315	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
635013006316	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013006317	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013006318	FeS/SAM binding site; other site
635013006319	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
635013006320	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013006321	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
635013006322	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
635013006323	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013006324	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013006325	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013006326	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013006327	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013006328	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013006329	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013006330	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013006331	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013006332	NHL repeat; Region: NHL; pfam01436
635013006333	NHL repeat; Region: NHL; pfam01436
635013006334	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
635013006335	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
635013006336	Uncharacterized conserved protein [Function unknown]; Region: COG5276
635013006337	LVIVD repeat; Region: LVIVD; pfam08309
635013006338	Uncharacterized membrane protein [Function unknown]; Region: COG3949
635013006339	Protein of unknown function (DUF458); Region: DUF458; cl00861
635013006340	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
635013006341	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
635013006342	homodimer interface [polypeptide binding]; other site
635013006343	substrate-cofactor binding pocket; other site
635013006344	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013006345	catalytic residue [active]
635013006346	Homoserine O-succinyltransferase; Region: HTS; pfam04204
635013006347	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
635013006348	proposed active site lysine [active]
635013006349	conserved cys residue [active]
635013006350	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
635013006351	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
635013006352	dimer interface [polypeptide binding]; other site
635013006353	putative functional site; other site
635013006354	putative MPT binding site; other site
635013006355	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
635013006356	putative MPT binding site; other site
635013006357	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013006358	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
635013006359	Walker A/P-loop; other site
635013006360	ATP binding site [chemical binding]; other site
635013006361	Q-loop/lid; other site
635013006362	ABC transporter signature motif; other site
635013006363	Walker B; other site
635013006364	D-loop; other site
635013006365	H-loop/switch region; other site
635013006366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013006367	dimer interface [polypeptide binding]; other site
635013006368	conserved gate region; other site
635013006369	putative PBP binding loops; other site
635013006370	ABC-ATPase subunit interface; other site
635013006371	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
635013006372	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
635013006373	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cl00451
635013006374	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013006375	molybdopterin cofactor binding site; other site
635013006376	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
635013006377	molybdopterin cofactor binding site; other site
635013006378	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
635013006379	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013006380	catalytic loop [active]
635013006381	iron binding site [ion binding]; other site
635013006382	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
635013006383	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013006384	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
635013006385	Helix-turn-helix domains; Region: HTH; cl00088
635013006386	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
635013006387	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013006388	S-adenosylmethionine binding site [chemical binding]; other site
635013006389	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
635013006390	metal-binding site [ion binding]
635013006391	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
635013006392	metal-binding site [ion binding]
635013006393	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
635013006394	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
635013006395	metal-binding site [ion binding]
635013006396	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
635013006397	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
635013006398	motif II; other site
635013006399	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
635013006400	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
635013006401	ATP binding site [chemical binding]; other site
635013006402	substrate interface [chemical binding]; other site
635013006403	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
635013006404	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
635013006405	dimer interface [polypeptide binding]; other site
635013006406	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013006407	catalytic residue [active]
635013006408	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
635013006409	thiS-thiF/thiG interaction site; other site
635013006410	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
635013006411	CPxP  motif; other site
635013006412	Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221
635013006413	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
635013006414	4Fe-4S binding domain; Region: Fer4; cl02805
635013006415	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
635013006416	ATP-sulfurylase; Region: ATPS; cd00517
635013006417	active site
635013006418	HXXH motif; other site
635013006419	flexible loop; other site
635013006420	Ferredoxin [Energy production and conversion]; Region: COG1146
635013006421	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013006422	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
635013006423	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006424	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
635013006425	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation of...; Region: APSK; cd02027
635013006426	ligand-binding site [chemical binding]; other site
635013006427	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
635013006428	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
635013006429	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
635013006430	Walker A/P-loop; other site
635013006431	ATP binding site [chemical binding]; other site
635013006432	Q-loop/lid; other site
635013006433	ABC transporter signature motif; other site
635013006434	Walker B; other site
635013006435	D-loop; other site
635013006436	H-loop/switch region; other site
635013006437	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
635013006438	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
635013006439	substrate binding pocket [chemical binding]; other site
635013006440	membrane-bound complex binding site; other site
635013006441	hinge residues; other site
635013006442	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
635013006443	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
635013006444	substrate binding site [chemical binding]; other site
635013006445	ATP binding site [chemical binding]; other site
635013006446	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
635013006447	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
635013006448	active site
635013006449	intersubunit interface [polypeptide binding]; other site
635013006450	catalytic residue [active]
635013006451	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
635013006452	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
635013006453	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
635013006454	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
635013006455	Walker A/P-loop; other site
635013006456	ATP binding site [chemical binding]; other site
635013006457	Q-loop/lid; other site
635013006458	ABC transporter signature motif; other site
635013006459	Walker B; other site
635013006460	D-loop; other site
635013006461	H-loop/switch region; other site
635013006462	TOBE domain; Region: TOBE_2; cl01440
635013006463	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
635013006464	muconate and chloromuconate cycloisomerases; Region: mucon_cyclo; TIGR02534
635013006465	metal binding site [ion binding]; metal-binding site
635013006466	substrate binding pocket [chemical binding]; other site
635013006467	Creatinine amidohydrolase; Region: Creatininase; cl00618
635013006468	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
635013006469	homotrimer interaction site [polypeptide binding]; other site
635013006470	putative active site [active]
635013006471	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
635013006472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013006473	dimer interface [polypeptide binding]; other site
635013006474	conserved gate region; other site
635013006475	putative PBP binding loops; other site
635013006476	ABC-ATPase subunit interface; other site
635013006477	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013006478	dimer interface [polypeptide binding]; other site
635013006479	conserved gate region; other site
635013006480	putative PBP binding loops; other site
635013006481	ABC-ATPase subunit interface; other site
635013006482	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
635013006483	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
635013006484	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
635013006485	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
635013006486	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
635013006487	Transcriptional regulator [Transcription]; Region: IclR; COG1414
635013006488	Helix-turn-helix domains; Region: HTH; cl00088
635013006489	Bacterial transcriptional regulator; Region: IclR; pfam01614
635013006490	Ubiquitin-like proteins; Region: UBQ; cl00155
635013006491	charged pocket; other site
635013006492	hydrophobic patch; other site
635013006493	NMT1-like family; Region: NMT1_2; cl15260
635013006494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013006495	dimer interface [polypeptide binding]; other site
635013006496	conserved gate region; other site
635013006497	ABC-ATPase subunit interface; other site
635013006498	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
635013006499	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
635013006500	Walker A/P-loop; other site
635013006501	ATP binding site [chemical binding]; other site
635013006502	Q-loop/lid; other site
635013006503	ABC transporter signature motif; other site
635013006504	Walker B; other site
635013006505	D-loop; other site
635013006506	H-loop/switch region; other site
635013006507	NIL domain; Region: NIL; cl09633
635013006508	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
635013006509	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
635013006510	homodimer interface [polypeptide binding]; other site
635013006511	substrate-cofactor binding pocket; other site
635013006512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013006513	catalytic residue [active]
635013006514	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
635013006515	MPN+ (JAMM) motif; other site
635013006516	Zinc-binding site [ion binding]; other site
635013006517	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
635013006518	Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080
635013006519	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013006520	CcmB protein; Region: CcmB; cl01016
635013006521	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
635013006522	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013006523	Walker A/P-loop; other site
635013006524	ATP binding site [chemical binding]; other site
635013006525	Q-loop/lid; other site
635013006526	ABC transporter signature motif; other site
635013006527	Walker B; other site
635013006528	D-loop; other site
635013006529	H-loop/switch region; other site
635013006530	Cytochrome C biogenesis protein; Region: CcmH; cl01179
635013006531	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013006532	CcmE; Region: CcmE; cl00994
635013006533	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; cl11412
635013006534	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
635013006535	Short C-terminal domain; Region: SHOCT; cl01373
635013006536	bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308
635013006537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
635013006538	Coenzyme A binding pocket [chemical binding]; other site
635013006539	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
635013006540	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
635013006541	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
635013006542	putative homotetramer interface [polypeptide binding]; other site
635013006543	putative homodimer interface [polypeptide binding]; other site
635013006544	putative allosteric switch controlling residues; other site
635013006545	putative metal binding site [ion binding]; other site
635013006546	putative homodimer-homodimer interface [polypeptide binding]; other site
635013006547	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
635013006548	RNA/DNA hybrid binding site [nucleotide binding]; other site
635013006549	active site
635013006550	Cupin domain; Region: Cupin_2; cl09118
635013006551	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
635013006552	Putative zinc ribbon domain; Region: DUF164; pfam02591
635013006553	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
635013006554	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
635013006555	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
635013006556	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006557	Band_7_prohibitin. A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup group includes proteins similar to prohibitin (a lipid raft-associated integral membrane protein).  Individual proteins of this band 7 domain family may...; Region: Band_7_prohibitin; cd03401
635013006558	Heme NO binding; Region: HNOB; cl15268
635013006559	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
635013006560	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
635013006561	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
635013006562	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013006563	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
635013006564	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
635013006565	DNA binding residues [nucleotide binding]
635013006566	DNA primase; Validated; Region: dnaG; PRK05667
635013006567	CHC2 zinc finger; Region: zf-CHC2; cl15369
635013006568	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
635013006569	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
635013006570	active site
635013006571	metal binding site [ion binding]; metal-binding site
635013006572	interdomain interaction site; other site
635013006573	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
635013006574	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
635013006575	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013006576	Zn2+ binding site [ion binding]; other site
635013006577	Mg2+ binding site [ion binding]; other site
635013006578	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
635013006579	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
635013006580	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
635013006581	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
635013006582	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
635013006583	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647
635013006584	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
635013006585	Walker A/P-loop; other site
635013006586	ATP binding site [chemical binding]; other site
635013006587	Q-loop/lid; other site
635013006588	ABC transporter signature motif; other site
635013006589	Walker B; other site
635013006590	D-loop; other site
635013006591	H-loop/switch region; other site
635013006592	Cobalt transport protein; Region: CbiQ; cl00463
635013006593	Transposase domain (DUF772); Region: DUF772; cl15789
635013006594	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013006595	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
635013006596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013006597	dimer interface [polypeptide binding]; other site
635013006598	conserved gate region; other site
635013006599	putative PBP binding loops; other site
635013006600	ABC-ATPase subunit interface; other site
635013006601	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
635013006602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013006603	dimer interface [polypeptide binding]; other site
635013006604	conserved gate region; other site
635013006605	putative PBP binding loops; other site
635013006606	ABC-ATPase subunit interface; other site
635013006607	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
635013006608	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013006609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013006610	active site
635013006611	phosphorylation site [posttranslational modification]
635013006612	intermolecular recognition site; other site
635013006613	dimerization interface [polypeptide binding]; other site
635013006614	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013006615	DNA binding site [nucleotide binding]
635013006616	FOG: CBS domain [General function prediction only]; Region: COG0517
635013006617	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the BON (bacterial OsmY and nodulation domain) domain. BON is a putative phospholipid-binding domain found in a family of osmotic shock protection...; Region: CBS_pair_BON_assoc; cd04586
635013006618	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
635013006619	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
635013006620	putative dimer interface [polypeptide binding]; other site
635013006621	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
635013006622	motif II; other site
635013006623	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
635013006624	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc; cd04598
635013006625	FOG: CBS domain [General function prediction only]; Region: COG0517
635013006626	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013006627	metal binding site [ion binding]; metal-binding site
635013006628	active site
635013006629	I-site; other site
635013006630	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
635013006631	active site
635013006632	catalytic triad [active]
635013006633	FlgD Ig-like domain; Region: FlgD_ig; cl15790
635013006634	pyruvate kinase; Provisional; Region: PRK06354
635013006635	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
635013006636	domain interfaces; other site
635013006637	active site
635013006638	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
635013006639	pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555
635013006640	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
635013006641	active site
635013006642	ADP/pyrophosphate binding site [chemical binding]; other site
635013006643	dimerization interface [polypeptide binding]; other site
635013006644	allosteric effector site; other site
635013006645	fructose-1,6-bisphosphate binding site; other site
635013006646	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
635013006647	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
635013006648	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
635013006649	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
635013006650	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
635013006651	Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437
635013006652	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
635013006653	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
635013006654	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
635013006655	generic binding surface II; other site
635013006656	generic binding surface I; other site
635013006657	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013006658	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
635013006659	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013006660	FeS/SAM binding site; other site
635013006661	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
635013006662	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
635013006663	PilZ domain; Region: PilZ; cl01260
635013006664	Domain of unknown function DUF77; Region: DUF77; cl00307
635013006665	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013006666	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
635013006667	metal binding site 2 [ion binding]; metal-binding site
635013006668	putative DNA binding helix; other site
635013006669	metal binding site 1 [ion binding]; metal-binding site
635013006670	dimer interface [polypeptide binding]; other site
635013006671	structural Zn2+ binding site [ion binding]; other site
635013006672	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
635013006673	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
635013006674	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
635013006675	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
635013006676	Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg); Region: PhaP_Bmeg; cl09820
635013006677	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
635013006678	cell division protein; Validated; Region: ftsH; CHL00176
635013006679	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
635013006680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013006681	Walker A motif; other site
635013006682	ATP binding site [chemical binding]; other site
635013006683	Walker B motif; other site
635013006684	arginine finger; other site
635013006685	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
635013006686	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
635013006687	ligand binding site [chemical binding]; other site
635013006688	flexible hinge region; other site
635013006689	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
635013006690	putative switch regulator; other site
635013006691	non-specific DNA interactions [nucleotide binding]; other site
635013006692	DNA binding site [nucleotide binding]
635013006693	sequence specific DNA binding site [nucleotide binding]; other site
635013006694	putative cAMP binding site [chemical binding]; other site
635013006695	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
635013006696	Walker A motif; other site
635013006697	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
635013006698	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
635013006699	GTP binding site; other site
635013006700	FdhD/NarQ family; Region: FdhD-NarQ; cl00659
635013006701	L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196
635013006702	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
635013006703	putative active site [active]
635013006704	putative metal binding site [ion binding]; other site
635013006705	Methyltransferase domain; Region: Methyltransf_31; pfam13847
635013006706	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013006707	S-adenosylmethionine binding site [chemical binding]; other site
635013006708	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cd00363
635013006709	active site
635013006710	ADP/pyrophosphate binding site [chemical binding]; other site
635013006711	dimerization interface [polypeptide binding]; other site
635013006712	allosteric effector site; other site
635013006713	fructose-1,6-bisphosphate binding site; other site
635013006714	FOG: CBS domain [General function prediction only]; Region: COG0517
635013006715	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
635013006716	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
635013006717	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
635013006718	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
635013006719	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
635013006720	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
635013006721	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
635013006722	aconitate hydratase; Validated; Region: PRK07229
635013006723	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
635013006724	substrate binding site [chemical binding]; other site
635013006725	ligand binding site [chemical binding]; other site
635013006726	Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle.  Cis-aconitate is formed as an intermediate product during the course...; Region: AcnA_Bact_Swivel; cd01579
635013006727	substrate binding site [chemical binding]; other site
635013006728	Protein of unknown function (DUF503); Region: DUF503; cl00669
635013006729	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
635013006730	VanW like protein; Region: VanW; pfam04294
635013006731	G5 domain; Region: G5; pfam07501
635013006732	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
635013006733	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
635013006734	Protein of unknown function (DUF3487); Region: DUF3487; cl13432
635013006735	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013006736	binding surface
635013006737	TPR motif; other site
635013006738	glycogen synthase; Provisional; Region: glgA; PRK00654
635013006739	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
635013006740	ADP-binding pocket [chemical binding]; other site
635013006741	homodimer interface [polypeptide binding]; other site
635013006742	S-layer homology domain; Region: SLH; pfam00395
635013006743	S-layer homology domain; Region: SLH; pfam00395
635013006744	PrcB C-terminal; Region: PrcB_C; pfam14343
635013006745	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
635013006746	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013006747	Walker A/P-loop; other site
635013006748	ATP binding site [chemical binding]; other site
635013006749	ABC transporter signature motif; other site
635013006750	Walker B; other site
635013006751	D-loop; other site
635013006752	Putative pyruvate format-lyase activating enzyme (DUF1786); Region: DUF1786; cl01638
635013006753	glycogen synthase; Provisional; Region: glgA; PRK00654
635013006754	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
635013006755	ADP-binding pocket [chemical binding]; other site
635013006756	homodimer interface [polypeptide binding]; other site
635013006757	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
635013006758	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
635013006759	minor groove reading motif; other site
635013006760	helix-hairpin-helix signature motif; other site
635013006761	substrate binding pocket [chemical binding]; other site
635013006762	active site
635013006763	Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722
635013006764	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
635013006765	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
635013006766	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
635013006767	active site
635013006768	catalytic tetrad [active]
635013006769	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
635013006770	Protein of unknown function (DUF1189); Region: DUF1189; pfam06691
635013006771	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
635013006772	active site
635013006773	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
635013006774	active site
635013006775	nucleophile elbow; other site
635013006776	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013006777	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013006778	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013006779	active site
635013006780	phosphorylation site [posttranslational modification]
635013006781	intermolecular recognition site; other site
635013006782	dimerization interface [polypeptide binding]; other site
635013006783	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013006784	DNA binding site [nucleotide binding]
635013006785	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
635013006786	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013006787	dimer interface [polypeptide binding]; other site
635013006788	phosphorylation site [posttranslational modification]
635013006789	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013006790	ATP binding site [chemical binding]; other site
635013006791	Mg2+ binding site [ion binding]; other site
635013006792	G-X-G motif; other site
635013006793	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
635013006794	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
635013006795	aspartate aminotransferase; Provisional; Region: PRK06836
635013006796	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
635013006797	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013006798	homodimer interface [polypeptide binding]; other site
635013006799	catalytic residue [active]
635013006800	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
635013006801	Ligand Binding Site [chemical binding]; other site
635013006802	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
635013006803	CoenzymeA binding site [chemical binding]; other site
635013006804	subunit interaction site [polypeptide binding]; other site
635013006805	PHB binding site; other site
635013006806	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
635013006807	CotJB protein; Region: CotJB; pfam12652
635013006808	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
635013006809	dimanganese center [ion binding]; other site
635013006810	Sulphur transport; Region: Sulf_transp; cl01018
635013006811	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
635013006812	CPxP  motif; other site
635013006813	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
635013006814	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
635013006815	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
635013006816	active site
635013006817	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
635013006818	active site
635013006819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013006820	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
635013006821	Walker A motif; other site
635013006822	ATP binding site [chemical binding]; other site
635013006823	Walker B motif; other site
635013006824	arginine finger; other site
635013006825	pyruvate phosphate dikinase; Provisional; Region: PRK09279
635013006826	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
635013006827	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
635013006828	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
635013006829	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
635013006830	Helix-turn-helix domains; Region: HTH; cl00088
635013006831	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
635013006832	FOG: CBS domain [General function prediction only]; Region: COG0517
635013006833	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
635013006834	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
635013006835	dimer interface [polypeptide binding]; other site
635013006836	motif 1; other site
635013006837	active site
635013006838	motif 2; other site
635013006839	motif 3; other site
635013006840	nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369
635013006841	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
635013006842	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
635013006843	Recombination protein O N terminal; Region: RecO_N; cl15812
635013006844	Recombination protein O C terminal; Region: RecO_C; pfam02565
635013006845	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
635013006846	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
635013006847	AMP-binding enzyme; Region: AMP-binding; cl15778
635013006848	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
635013006849	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
635013006850	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
635013006851	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
635013006852	dimer interface [polypeptide binding]; other site
635013006853	PYR/PP interface [polypeptide binding]; other site
635013006854	TPP binding site [chemical binding]; other site
635013006855	substrate binding site [chemical binding]; other site
635013006856	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
635013006857	TPP-binding site; other site
635013006858	4Fe-4S binding domain; Region: Fer4; cl02805
635013006859	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006860	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08269
635013006861	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
635013006862	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006863	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
635013006864	DctM-like transporters; Region: DctM; pfam06808
635013006865	C4-dicarboxylate anaerobic carrier; Region: DcuC; cl15356
635013006866	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
635013006867	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
635013006868	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
635013006869	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
635013006870	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
635013006871	tetramer interface [polypeptide binding]; other site
635013006872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013006873	catalytic residue [active]
635013006874	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
635013006875	MgtE intracellular N domain; Region: MgtE_N; cl15244
635013006876	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
635013006877	Divalent cation transporter; Region: MgtE; cl00786
635013006878	GTPase Era; Reviewed; Region: era; PRK00089
635013006879	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
635013006880	G1 box; other site
635013006881	GTP/Mg2+ binding site [chemical binding]; other site
635013006882	Switch I region; other site
635013006883	G2 box; other site
635013006884	Switch II region; other site
635013006885	G3 box; other site
635013006886	G4 box; other site
635013006887	G5 box; other site
635013006888	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
635013006889	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
635013006890	active site
635013006891	catalytic motif [active]
635013006892	Zn binding site [ion binding]; other site
635013006893	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
635013006894	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
635013006895	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
635013006896	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
635013006897	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013006898	Zn2+ binding site [ion binding]; other site
635013006899	Mg2+ binding site [ion binding]; other site
635013006900	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
635013006901	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013006902	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
635013006903	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
635013006904	YabP family; Region: YabP; cl06766
635013006905	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
635013006906	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
635013006907	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
635013006908	dimer interface [polypeptide binding]; other site
635013006909	active site residues [active]
635013006910	Repair protein; Region: Repair_PSII; cl01535
635013006911	LemA family; Region: LemA; cl00742
635013006912	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
635013006913	active site
635013006914	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
635013006915	phosphopeptide binding site; other site
635013006916	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
635013006917	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
635013006918	TadE-like protein; Region: TadE; cl10688
635013006919	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013006920	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013006921	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
635013006922	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
635013006923	Walker A motif; other site
635013006924	hexamer interface [polypeptide binding]; other site
635013006925	ATP binding site [chemical binding]; other site
635013006926	Walker B motif; other site
635013006927	AAA domain; Region: AAA_31; pfam13614
635013006928	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013006929	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
635013006930	phosphopeptide binding site; other site
635013006931	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013006932	DNA binding site [nucleotide binding]
635013006933	GatB domain; Region: GatB_Yqey; cl11497
635013006934	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
635013006935	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
635013006936	nucleotide binding site/active site [active]
635013006937	HIT family signature motif; other site
635013006938	catalytic residue [active]
635013006939	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
635013006940	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
635013006941	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
635013006942	TRAM domain; Region: TRAM; cl01282
635013006943	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
635013006944	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
635013006945	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
635013006946	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013006947	chaperone protein DnaJ; Provisional; Region: PRK10767
635013006948	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
635013006949	HSP70 interaction site [polypeptide binding]; other site
635013006950	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
635013006951	substrate binding site [polypeptide binding]; other site
635013006952	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
635013006953	Zn binding sites [ion binding]; other site
635013006954	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
635013006955	dimer interface [polypeptide binding]; other site
635013006956	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
635013006957	lumazine synthase and riboflavin synthase; involved in the riboflavin (vitamin B2) biosynthetic pathway; Region: Lumazine_synthase-like; cl00317
635013006958	heat shock protein GrpE; Provisional; Region: PRK14140
635013006959	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
635013006960	dimer interface [polypeptide binding]; other site
635013006961	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
635013006962	chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309
635013006963	ring oligomerisation interface [polypeptide binding]; other site
635013006964	TCP-1/cpn60 chaperonin family; Region: Cpn60_TCP1; pfam00118
635013006965	ATP/Mg binding site [chemical binding]; other site
635013006966	hinge regions; other site
635013006967	stacking interactions; other site
635013006968	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
635013006969	Helix-turn-helix domains; Region: HTH; cl00088
635013006970	HrcA protein C terminal domain; Region: HrcA; pfam01628
635013006971	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
635013006972	HemN C-terminal domain; Region: HemN_C; pfam06969
635013006973	GTP-binding protein LepA; Provisional; Region: PRK05433
635013006974	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
635013006975	G1 box; other site
635013006976	putative GEF interaction site [polypeptide binding]; other site
635013006977	GTP/Mg2+ binding site [chemical binding]; other site
635013006978	Switch I region; other site
635013006979	G2 box; other site
635013006980	G3 box; other site
635013006981	Switch II region; other site
635013006982	G4 box; other site
635013006983	G5 box; other site
635013006984	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
635013006985	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
635013006986	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
635013006987	integral membrane protein MviN; Region: mviN; TIGR01695
635013006988	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
635013006989	stage II sporulation protein P; Region: spore_II_P; TIGR02867
635013006990	Membrane protein of unknown function; Region: DUF360; cl00850
635013006991	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
635013006992	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
635013006993	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
635013006994	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
635013006995	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
635013006996	Competence protein; Region: Competence; cl00471
635013006997	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013006998	SLBB domain; Region: SLBB; pfam10531
635013006999	comEA protein; Region: comE; TIGR01259
635013007000	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
635013007001	Amino acid permease; Region: AA_permease_2; pfam13520
635013007002	L,D-transpeptidase catalytic domain; Region: YkuD; cl15405
635013007003	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013007004	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
635013007005	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
635013007006	Walker A/P-loop; other site
635013007007	ATP binding site [chemical binding]; other site
635013007008	Q-loop/lid; other site
635013007009	ABC transporter signature motif; other site
635013007010	Walker B; other site
635013007011	D-loop; other site
635013007012	H-loop/switch region; other site
635013007013	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
635013007014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013007015	dimer interface [polypeptide binding]; other site
635013007016	conserved gate region; other site
635013007017	putative PBP binding loops; other site
635013007018	ABC-ATPase subunit interface; other site
635013007019	NMT1/THI5 like; Region: NMT1; pfam09084
635013007020	NMT1-like family; Region: NMT1_2; cl15260
635013007021	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
635013007022	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
635013007023	putative molybdopterin cofactor binding site [chemical binding]; other site
635013007024	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
635013007025	putative molybdopterin cofactor binding site; other site
635013007026	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cd09742
635013007027	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
635013007028	DNA-binding site [nucleotide binding]; DNA binding site
635013007029	RNA-binding motif; other site
635013007030	CRISPR-associated protein; Region: TIGR03986
635013007031	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
635013007032	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
635013007033	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
635013007034	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
635013007035	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
635013007036	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
635013007037	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853
635013007038	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
635013007039	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
635013007040	YcfA-like protein; Region: YcfA; cl00752
635013007041	Integrase core domain; Region: rve; cl01316
635013007042	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
635013007043	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
635013007044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013007045	Walker A motif; other site
635013007046	ATP binding site [chemical binding]; other site
635013007047	Walker B motif; other site
635013007048	arginine finger; other site
635013007049	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
635013007050	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
635013007051	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
635013007052	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
635013007053	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
635013007054	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007055	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
635013007056	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
635013007057	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
635013007058	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
635013007059	Haemagglutinin; Region: Hemagglutinin; pfam00509
635013007060	peptide chain release factor 2; Validated; Region: prfB; PRK00578
635013007061	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443
635013007062	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
635013007063	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
635013007064	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
635013007065	GAF domain; Region: GAF; cl15785
635013007066	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013007067	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013007068	Walker A motif; other site
635013007069	ATP binding site [chemical binding]; other site
635013007070	Walker B motif; other site
635013007071	arginine finger; other site
635013007072	Helix-turn-helix domains; Region: HTH; cl00088
635013007073	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
635013007074	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
635013007075	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
635013007076	Domain of unknown function (DUF1858); Region: DUF1858; cl14817
635013007077	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
635013007078	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
635013007079	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013007080	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
635013007081	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
635013007082	CGGC domain; Region: CGGC; cl02356
635013007083	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013007084	S-adenosylmethionine binding site [chemical binding]; other site
635013007085	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
635013007086	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
635013007087	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
635013007088	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
635013007089	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
635013007090	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
635013007091	HIGH motif; other site
635013007092	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
635013007093	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
635013007094	active site
635013007095	KMSKS motif; other site
635013007096	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
635013007097	tRNA binding surface [nucleotide binding]; other site
635013007098	AMP-binding domain protein; Validated; Region: PRK08315
635013007099	AMP-binding enzyme; Region: AMP-binding; cl15778
635013007100	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013007101	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013007102	Zn2+ binding site [ion binding]; other site
635013007103	Mg2+ binding site [ion binding]; other site
635013007104	Oligomerisation domain; Region: Oligomerisation; cl00519
635013007105	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
635013007106	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013007107	RRM (RNA recognition motif), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA...; Region: RRM; cd00590
635013007108	RNA/DNA binding site [nucleotide binding]; other site
635013007109	RRM dimerization site [polypeptide binding]; other site
635013007110	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
635013007111	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
635013007112	active site
635013007113	(T/H)XGH motif; other site
635013007114	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
635013007115	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
635013007116	putative catalytic cysteine [active]
635013007117	gamma-glutamyl kinase; Provisional; Region: PRK05429
635013007118	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
635013007119	nucleotide binding site [chemical binding]; other site
635013007120	homotetrameric interface [polypeptide binding]; other site
635013007121	putative phosphate binding site [ion binding]; other site
635013007122	putative allosteric binding site; other site
635013007123	PUA domain; Region: PUA; cl00607
635013007124	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
635013007125	GTPase CgtA; Reviewed; Region: obgE; PRK12297
635013007126	GTP1/OBG; Region: GTP1_OBG; pfam01018
635013007127	Obg GTPase; Region: Obg; cd01898
635013007128	G1 box; other site
635013007129	GTP/Mg2+ binding site [chemical binding]; other site
635013007130	Switch I region; other site
635013007131	G2 box; other site
635013007132	G3 box; other site
635013007133	Switch II region; other site
635013007134	G4 box; other site
635013007135	G5 box; other site
635013007136	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
635013007137	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194
635013007138	Spore germination protein; Region: Spore_permease; cl15802
635013007139	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
635013007140	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
635013007141	Spore germination protein; Region: Spore_permease; cl15802
635013007142	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194
635013007143	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
635013007144	Protein of unknown function (DUF464); Region: DUF464; cl01080
635013007145	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
635013007146	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
635013007147	ribonuclease G; Provisional; Region: PRK11712
635013007148	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
635013007149	homodimer interface [polypeptide binding]; other site
635013007150	oligonucleotide binding site [chemical binding]; other site
635013007151	TRAM domain; Region: TRAM; cl01282
635013007152	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
635013007153	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
635013007154	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
635013007155	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013007156	B12 binding site [chemical binding]; other site
635013007157	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013007158	FeS/SAM binding site; other site
635013007159	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
635013007160	active site
635013007161	putative substrate binding region [chemical binding]; other site
635013007162	Peptidase family M23; Region: Peptidase_M23; pfam01551
635013007163	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
635013007164	Septum formation topological specificity factor MinE; Region: MinE; cl00538
635013007165	septum site-determining protein MinD; Region: minD_bact; TIGR01968
635013007166	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
635013007167	P-loop; other site
635013007168	ADP binding residues [chemical binding]; other site
635013007169	Switch I; other site
635013007170	Switch II; other site
635013007171	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
635013007172	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
635013007173	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
635013007174	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013007175	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013007176	rod shape-determining protein MreD; Region: MreD; cl01087
635013007177	TPR/MLP1/MLP2-like protein; Region: TPR_MLP1_2; pfam07926
635013007178	rod shape-determining protein MreC; Region: MreC; pfam04085
635013007179	rod shape-determining protein MreB; Provisional; Region: PRK13927
635013007180	Cell division protein FtsA; Region: FtsA; cl11496
635013007181	hypothetical protein; Reviewed; Region: PRK00024
635013007182	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
635013007183	MPN+ (JAMM) motif; other site
635013007184	Zinc-binding site [ion binding]; other site
635013007185	Maf-like protein; Region: Maf; pfam02545
635013007186	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
635013007187	active site
635013007188	dimer interface [polypeptide binding]; other site
635013007189	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
635013007190	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
635013007191	dimer interface [polypeptide binding]; other site
635013007192	[2Fe-2S] cluster binding site [ion binding]; other site
635013007193	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
635013007194	dimer interface [polypeptide binding]; other site
635013007195	[2Fe-2S] cluster binding site [ion binding]; other site
635013007196	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
635013007197	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
635013007198	SLBB domain; Region: SLBB; pfam10531
635013007199	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
635013007200	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013007201	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013007202	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
635013007203	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
635013007204	putative dimer interface [polypeptide binding]; other site
635013007205	[2Fe-2S] cluster binding site [ion binding]; other site
635013007206	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
635013007207	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
635013007208	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013007209	Sporulation related domain; Region: SPOR; cl10051
635013007210	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
635013007211	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
635013007212	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
635013007213	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013007214	non-specific DNA binding site [nucleotide binding]; other site
635013007215	salt bridge; other site
635013007216	sequence-specific DNA binding site [nucleotide binding]; other site
635013007217	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
635013007218	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013007219	non-specific DNA binding site [nucleotide binding]; other site
635013007220	salt bridge; other site
635013007221	sequence-specific DNA binding site [nucleotide binding]; other site
635013007222	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
635013007223	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
635013007224	HIGH motif; other site
635013007225	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
635013007226	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
635013007227	active site
635013007228	KMSKS motif; other site
635013007229	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
635013007230	tRNA binding surface [nucleotide binding]; other site
635013007231	anticodon binding site; other site
635013007232	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
635013007233	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
635013007234	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
635013007235	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
635013007236	Predicted GTPase [General function prediction only]; Region: COG0218
635013007237	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
635013007238	G1 box; other site
635013007239	GTP/Mg2+ binding site [chemical binding]; other site
635013007240	Switch I region; other site
635013007241	G2 box; other site
635013007242	G3 box; other site
635013007243	Switch II region; other site
635013007244	G4 box; other site
635013007245	G5 box; other site
635013007246	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
635013007247	Found in ATP-dependent protease La (LON); Region: LON; smart00464
635013007248	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013007249	Walker A motif; other site
635013007250	ATP binding site [chemical binding]; other site
635013007251	Walker B motif; other site
635013007252	arginine finger; other site
635013007253	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
635013007254	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
635013007255	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013007256	Walker A motif; other site
635013007257	ATP binding site [chemical binding]; other site
635013007258	Walker B motif; other site
635013007259	arginine finger; other site
635013007260	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
635013007261	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
635013007262	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
635013007263	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013007264	Walker A motif; other site
635013007265	ATP binding site [chemical binding]; other site
635013007266	Walker B motif; other site
635013007267	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
635013007268	Clp protease; Region: CLP_protease; pfam00574
635013007269	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
635013007270	oligomer interface [polypeptide binding]; other site
635013007271	active site residues [active]
635013007272	trigger factor; Provisional; Region: tig; PRK01490
635013007273	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
635013007274	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
635013007275	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
635013007276	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
635013007277	active site
635013007278	metal binding site [ion binding]; metal-binding site
635013007279	homotetramer interface [polypeptide binding]; other site
635013007280	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
635013007281	active site
635013007282	dimerization interface [polypeptide binding]; other site
635013007283	ribonuclease PH; Reviewed; Region: rph; PRK00173
635013007284	Ribonuclease PH; Region: RNase_PH_bact; cd11362
635013007285	hexamer interface [polypeptide binding]; other site
635013007286	active site
635013007287	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013007288	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
635013007289	Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775
635013007290	Predicted transcriptional regulators [Transcription]; Region: COG1725
635013007291	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
635013007292	DNA-binding site [nucleotide binding]; DNA binding site
635013007293	IMP dehydrogenase family protein; Region: IMP_DH_rel_2; TIGR01304
635013007294	Bacterial SH3 domain; Region: SH3_3; cl02551
635013007295	Bacterial SH3 domain; Region: SH3_3; cl02551
635013007296	AMIN domain; Region: AMIN; pfam11741
635013007297	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
635013007298	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
635013007299	active site
635013007300	metal binding site [ion binding]; metal-binding site
635013007301	Sporulation and spore germination; Region: Germane; cl11253
635013007302	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
635013007303	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
635013007304	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
635013007305	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
635013007306	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
635013007307	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
635013007308	flagellar operon protein TIGR03826; Region: YvyF
635013007309	S-layer homology domain; Region: SLH; pfam00395
635013007310	S-layer homology domain; Region: SLH; pfam00395
635013007311	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
635013007312	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
635013007313	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
635013007314	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
635013007315	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
635013007316	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
635013007317	substrate binding pocket [chemical binding]; other site
635013007318	membrane-bound complex binding site; other site
635013007319	hinge residues; other site
635013007320	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
635013007321	ABC-type phosphate/phosphonate transport system. Phosphonates are a class of organophosphorus compounds characterized by a chemically stable carbon-to-phosphorus (C-P) bond.  Phosphonates are widespread among naturally occurring compounds in all...; Region: ABC_PhnC_transporter; cd03256
635013007322	Walker A/P-loop; other site
635013007323	ATP binding site [chemical binding]; other site
635013007324	Q-loop/lid; other site
635013007325	ABC transporter signature motif; other site
635013007326	Walker B; other site
635013007327	D-loop; other site
635013007328	H-loop/switch region; other site
635013007329	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
635013007330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
635013007331	dimer interface [polypeptide binding]; other site
635013007332	conserved gate region; other site
635013007333	putative PBP binding loops; other site
635013007334	ABC-ATPase subunit interface; other site
635013007335	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
635013007336	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
635013007337	putative active site [active]
635013007338	putative NTP binding site [chemical binding]; other site
635013007339	putative nucleic acid binding site [nucleotide binding]; other site
635013007340	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
635013007341	Flagellin N-methylase; Region: FliB; cl00497
635013007342	Protein of unknown function (DUF964); Region: DUF964; cl01483
635013007343	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
635013007344	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
635013007345	S-layer homology domain; Region: SLH; pfam00395
635013007346	S-layer homology domain; Region: SLH; pfam00395
635013007347	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
635013007348	Protein of unknown function (DUF3604); Region: DUF3604; pfam12228
635013007349	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
635013007350	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
635013007351	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013007352	Cytochrome c552; Region: Cytochrom_C552; pfam02335
635013007353	Predicted ATPase, RNase L inhibitor (RLI) homolog [General function prediction only]; Region: COG1245
635013007354	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013007355	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013007356	O-Antigen ligase; Region: Wzy_C; cl04850
635013007357	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
635013007358	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
635013007359	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013007360	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
635013007361	dinuclear metal binding motif [ion binding]; other site
635013007362	radical SAM protein, TIGR01212 family; Region: TIGR01212
635013007363	DEAD-like helicases superfamily; Region: DEXDc; smart00487
635013007364	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013007365	ATP binding site [chemical binding]; other site
635013007366	putative Mg++ binding site [ion binding]; other site
635013007367	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013007368	nucleotide binding region [chemical binding]; other site
635013007369	ATP-binding site [chemical binding]; other site
635013007370	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
635013007371	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250
635013007372	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
635013007373	Walker A/P-loop; other site
635013007374	ATP binding site [chemical binding]; other site
635013007375	Q-loop/lid; other site
635013007376	ABC transporter signature motif; other site
635013007377	Walker B; other site
635013007378	D-loop; other site
635013007379	H-loop/switch region; other site
635013007380	4Fe-4S binding domain; Region: Fer4_5; pfam12801
635013007381	Citrate synthase (CS) catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the oxidative citric acid cycle (TCA or Krebs cycle). Peroxisomal CS is involved in the glyoxylate...; Region: citrate_synt_like_1_2; cd06113
635013007382	dimer interface [polypeptide binding]; other site
635013007383	Citrate synthase; Region: Citrate_synt; pfam00285
635013007384	active site
635013007385	citrylCoA binding site [chemical binding]; other site
635013007386	oxalacetate/citrate binding site [chemical binding]; other site
635013007387	coenzyme A binding site [chemical binding]; other site
635013007388	catalytic triad [active]
635013007389	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
635013007390	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
635013007391	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
635013007392	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
635013007393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013007394	putative substrate translocation pore; other site
635013007395	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
635013007396	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
635013007397	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
635013007398	catalytic loop [active]
635013007399	iron binding site [ion binding]; other site
635013007400	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
635013007401	MFS/sugar transport protein; Region: MFS_2; pfam13347
635013007402	MFS/sugar transport protein; Region: MFS_2; pfam13347
635013007403	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
635013007404	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
635013007405	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
635013007406	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013007407	B12 binding site [chemical binding]; other site
635013007408	cobalt ligand [ion binding]; other site
635013007409	Helix-turn-helix domains; Region: HTH; cl00088
635013007410	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
635013007411	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
635013007412	DNA-binding site [nucleotide binding]; DNA binding site
635013007413	UTRA domain; Region: UTRA; cl01230
635013007414	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013007415	methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370
635013007416	B12 binding site [chemical binding]; other site
635013007417	cobalt ligand [ion binding]; other site
635013007418	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
635013007419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013007420	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
635013007421	putative substrate translocation pore; other site
635013007422	CmuA_CmuC_like: uncharacterized protein family similar to uroporphyrinogen decarboxylase (URO-D) and the methyltransferases CmuA and CmuC; Region: CmuA_CmuC_like; cd03308
635013007423	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013007424	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013007425	B12 binding site [chemical binding]; other site
635013007426	cobalt ligand [ion binding]; other site
635013007427	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
635013007428	substrate binding pocket [chemical binding]; other site
635013007429	dimer interface [polypeptide binding]; other site
635013007430	inhibitor binding site; inhibition site
635013007431	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
635013007432	Cache domain; Region: Cache_1; pfam02743
635013007433	signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549
635013007434	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013007435	dimerization interface [polypeptide binding]; other site
635013007436	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013007437	dimer interface [polypeptide binding]; other site
635013007438	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
635013007439	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
635013007440	dimer interface [polypeptide binding]; other site
635013007441	putative CheW interface [polypeptide binding]; other site
635013007442	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
635013007443	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
635013007444	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
635013007445	FtsX-like permease family; Region: FtsX; cl15850
635013007446	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
635013007447	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
635013007448	Walker A/P-loop; other site
635013007449	ATP binding site [chemical binding]; other site
635013007450	Q-loop/lid; other site
635013007451	ABC transporter signature motif; other site
635013007452	Walker B; other site
635013007453	D-loop; other site
635013007454	H-loop/switch region; other site
635013007455	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
635013007456	E3 interaction surface; other site
635013007457	lipoyl attachment site [posttranslational modification]; other site
635013007458	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013007459	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013007460	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013007461	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
635013007462	ABC-2 type transporter; Region: ABC2_membrane; cl11417
635013007463	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
635013007464	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
635013007465	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007466	Walker A/P-loop; other site
635013007467	ATP binding site [chemical binding]; other site
635013007468	Q-loop/lid; other site
635013007469	ABC transporter signature motif; other site
635013007470	Walker B; other site
635013007471	D-loop; other site
635013007472	H-loop/switch region; other site
635013007473	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013007474	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013007475	active site
635013007476	phosphorylation site [posttranslational modification]
635013007477	intermolecular recognition site; other site
635013007478	dimerization interface [polypeptide binding]; other site
635013007479	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013007480	DNA binding site [nucleotide binding]
635013007481	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013007482	dimer interface [polypeptide binding]; other site
635013007483	phosphorylation site [posttranslational modification]
635013007484	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013007485	ATP binding site [chemical binding]; other site
635013007486	Mg2+ binding site [ion binding]; other site
635013007487	G-X-G motif; other site
635013007488	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
635013007489	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013007490	dimerization interface [polypeptide binding]; other site
635013007491	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013007492	dimer interface [polypeptide binding]; other site
635013007493	phosphorylation site [posttranslational modification]
635013007494	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013007495	ATP binding site [chemical binding]; other site
635013007496	Mg2+ binding site [ion binding]; other site
635013007497	G-X-G motif; other site
635013007498	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013007499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013007500	active site
635013007501	phosphorylation site [posttranslational modification]
635013007502	intermolecular recognition site; other site
635013007503	dimerization interface [polypeptide binding]; other site
635013007504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013007505	DNA binding site [nucleotide binding]
635013007506	Integrase core domain; Region: rve; cl01316
635013007507	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
635013007508	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
635013007509	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013007510	Walker A motif; other site
635013007511	ATP binding site [chemical binding]; other site
635013007512	Walker B motif; other site
635013007513	arginine finger; other site
635013007514	Helix-turn-helix domains; Region: HTH; cl00088
635013007515	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
635013007516	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
635013007517	putative FMN binding site [chemical binding]; other site
635013007518	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
635013007519	CPxP  motif; other site
635013007520	putative inner membrane protein; Provisional; Region: PRK11099
635013007521	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
635013007522	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
635013007523	Accessory gene regulator B; Region: AgrB; cl01873
635013007524	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
635013007525	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013007526	PAS domain; Region: PAS_9; pfam13426
635013007527	PAS domain S-box; Region: sensory_box; TIGR00229
635013007528	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013007529	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013007530	metal binding site [ion binding]; metal-binding site
635013007531	active site
635013007532	I-site; other site
635013007533	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
635013007534	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
635013007535	FAD binding site [chemical binding]; other site
635013007536	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
635013007537	S-layer homology domain; Region: SLH; pfam00395
635013007538	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
635013007539	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
635013007540	manganese transport transcriptional regulator; Provisional; Region: PRK03902
635013007541	Helix-turn-helix domains; Region: HTH; cl00088
635013007542	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
635013007543	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
635013007544	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
635013007545	Walker A/P-loop; other site
635013007546	ATP binding site [chemical binding]; other site
635013007547	Q-loop/lid; other site
635013007548	ABC transporter signature motif; other site
635013007549	Walker B; other site
635013007550	D-loop; other site
635013007551	H-loop/switch region; other site
635013007552	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
635013007553	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
635013007554	Walker A/P-loop; other site
635013007555	ATP binding site [chemical binding]; other site
635013007556	Q-loop/lid; other site
635013007557	ABC transporter signature motif; other site
635013007558	Walker B; other site
635013007559	D-loop; other site
635013007560	H-loop/switch region; other site
635013007561	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
635013007562	TM-ABC transporter signature motif; other site
635013007563	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
635013007564	TM-ABC transporter signature motif; other site
635013007565	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
635013007566	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
635013007567	putative ligand binding site [chemical binding]; other site
635013007568	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
635013007569	intersubunit interface [polypeptide binding]; other site
635013007570	active site
635013007571	catalytic residue [active]
635013007572	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
635013007573	active site
635013007574	tetramer interface; other site
635013007575	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
635013007576	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
635013007577	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
635013007578	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
635013007579	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
635013007580	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
635013007581	active site
635013007582	homotetramer interface [polypeptide binding]; other site
635013007583	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
635013007584	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
635013007585	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
635013007586	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
635013007587	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
635013007588	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
635013007589	DNA binding residues [nucleotide binding]
635013007590	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
635013007591	Major Facilitator Superfamily; Region: MFS_1; pfam07690
635013007592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013007593	putative substrate translocation pore; other site
635013007594	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
635013007595	Helix-turn-helix domains; Region: HTH; cl00088
635013007596	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
635013007597	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
635013007598	dimerization interface [polypeptide binding]; other site
635013007599	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013007600	dimer interface [polypeptide binding]; other site
635013007601	phosphorylation site [posttranslational modification]
635013007602	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013007603	ATP binding site [chemical binding]; other site
635013007604	Mg2+ binding site [ion binding]; other site
635013007605	G-X-G motif; other site
635013007606	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
635013007607	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013007608	active site
635013007609	phosphorylation site [posttranslational modification]
635013007610	intermolecular recognition site; other site
635013007611	dimerization interface [polypeptide binding]; other site
635013007612	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
635013007613	DNA binding site [nucleotide binding]
635013007614	nascent polypeptide-associated complex protein; Reviewed; Region: nac; PRK06369
635013007615	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
635013007616	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
635013007617	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007618	Walker A/P-loop; other site
635013007619	ATP binding site [chemical binding]; other site
635013007620	Q-loop/lid; other site
635013007621	ABC transporter signature motif; other site
635013007622	Walker B; other site
635013007623	D-loop; other site
635013007624	H-loop/switch region; other site
635013007625	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
635013007626	TM-ABC transporter signature motif; other site
635013007627	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
635013007628	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
635013007629	zinc binding site [ion binding]; other site
635013007630	putative ligand binding site [chemical binding]; other site
635013007631	S23 ribosomal protein; Region: Ribosomal_S23p; cl05287
635013007632	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
635013007633	SmpB-tmRNA interface; other site
635013007634	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
635013007635	AMP-binding enzyme; Region: AMP-binding; cl15778
635013007636	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013007637	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
635013007638	non-specific DNA binding site [nucleotide binding]; other site
635013007639	salt bridge; other site
635013007640	sequence-specific DNA binding site [nucleotide binding]; other site
635013007641	Cupin domain; Region: Cupin_2; cl09118
635013007642	ribonuclease R; Region: RNase_R; TIGR02063
635013007643	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
635013007644	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
635013007645	RNB domain; Region: RNB; pfam00773
635013007646	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
635013007647	RNA binding site [nucleotide binding]; other site
635013007648	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013007649	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
635013007650	AMP-binding enzyme; Region: AMP-binding; cl15778
635013007651	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013007652	AMP-binding enzyme; Region: AMP-binding; cl15778
635013007653	AMP-binding enzyme; Region: AMP-binding; cl15778
635013007654	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013007655	Protein of unknown function (DUF2679); Region: DUF2679; pfam10882
635013007656	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
635013007657	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
635013007658	ABC-2 type transporter; Region: ABC2_membrane; cl11417
635013007659	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
635013007660	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
635013007661	Walker A/P-loop; other site
635013007662	ATP binding site [chemical binding]; other site
635013007663	Q-loop/lid; other site
635013007664	ABC transporter signature motif; other site
635013007665	Walker B; other site
635013007666	D-loop; other site
635013007667	H-loop/switch region; other site
635013007668	Predicted transcriptional regulators [Transcription]; Region: COG1725
635013007669	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
635013007670	DNA-binding site [nucleotide binding]; DNA binding site
635013007671	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
635013007672	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
635013007673	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
635013007674	Walker A/P-loop; other site
635013007675	ATP binding site [chemical binding]; other site
635013007676	Q-loop/lid; other site
635013007677	ABC transporter signature motif; other site
635013007678	Walker B; other site
635013007679	D-loop; other site
635013007680	H-loop/switch region; other site
635013007681	Predicted transcriptional regulators [Transcription]; Region: COG1725
635013007682	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
635013007683	DNA-binding site [nucleotide binding]; DNA binding site
635013007684	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
635013007685	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
635013007686	enolase; Provisional; Region: eno; PRK00077
635013007687	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
635013007688	dimer interface [polypeptide binding]; other site
635013007689	metal binding site [ion binding]; metal-binding site
635013007690	substrate binding pocket [chemical binding]; other site
635013007691	Sulfatase; Region: Sulfatase; cl10460
635013007692	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
635013007693	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
635013007694	substrate binding site [chemical binding]; other site
635013007695	dimer interface [polypeptide binding]; other site
635013007696	catalytic triad [active]
635013007697	Phosphoglycerate kinase; Region: PGK; pfam00162
635013007698	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
635013007699	substrate binding site [chemical binding]; other site
635013007700	hinge regions; other site
635013007701	ADP binding site [chemical binding]; other site
635013007702	catalytic site [active]
635013007703	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
635013007704	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013007705	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
635013007706	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
635013007707	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
635013007708	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
635013007709	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
635013007710	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
635013007711	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
635013007712	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
635013007713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
635013007714	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
635013007715	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
635013007716	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
635013007717	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
635013007718	phosphate binding site [ion binding]; other site
635013007719	putative substrate binding pocket [chemical binding]; other site
635013007720	dimer interface [polypeptide binding]; other site
635013007721	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
635013007722	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
635013007723	putative hydrolase; Validated; Region: PRK09248
635013007724	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
635013007725	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
635013007726	putative hydrolase; Validated; Region: PRK09248
635013007727	bifunctional phosphoglucose/phosphomannose isomerase; Validated; Region: PRK08674
635013007728	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_1; cd05017
635013007729	dimer interface [polypeptide binding]; other site
635013007730	active site
635013007731	The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to...; Region: SIS_PGI_PMI_2; cd05637
635013007732	dimer interface [polypeptide binding]; other site
635013007733	active site
635013007734	glycogen debranching enzyme, archaeal type, putative; Region: gde_arch; TIGR01561
635013007735	Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439
635013007736	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
635013007737	oligosaccharide amylase; Region: oligosac_amyl; TIGR01577
635013007738	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
635013007739	DOMON-like domain of various glycoside hydrolases; Region: DOMON_glucodextranase_like; cd09626
635013007740	putative ligand binding site [chemical binding]; other site
635013007741	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
635013007742	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
635013007743	Membrane protein of unknown function; Region: DUF360; cl00850
635013007744	Predicted membrane protein [Function unknown]; Region: COG2119
635013007745	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
635013007746	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
635013007747	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
635013007748	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
635013007749	DRTGG domain; Region: DRTGG; cl12147
635013007750	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
635013007751	DHH family; Region: DHH; pfam01368
635013007752	DHHA2 domain; Region: DHHA2; pfam02833
635013007753	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
635013007754	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
635013007755	GIY-YIG motif/motif A; other site
635013007756	active site
635013007757	catalytic site [active]
635013007758	putative DNA binding site [nucleotide binding]; other site
635013007759	metal binding site [ion binding]; metal-binding site
635013007760	UvrB/uvrC motif; Region: UVR; pfam02151
635013007761	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
635013007762	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
635013007763	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
635013007764	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
635013007765	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
635013007766	excinuclease ABC subunit B; Provisional; Region: PRK05298
635013007767	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013007768	ATP binding site [chemical binding]; other site
635013007769	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013007770	nucleotide binding region [chemical binding]; other site
635013007771	ATP-binding site [chemical binding]; other site
635013007772	Ultra-violet resistance protein B; Region: UvrB; pfam12344
635013007773	UvrB/uvrC motif; Region: UVR; pfam02151
635013007774	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
635013007775	active site
635013007776	Fe-S cluster binding site [ion binding]; other site
635013007777	hypothetical protein; Provisional; Region: PRK06851
635013007778	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007779	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007780	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
635013007781	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
635013007782	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
635013007783	C-terminal peptidase (prc); Region: prc; TIGR00225
635013007784	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
635013007785	protein binding site [polypeptide binding]; other site
635013007786	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
635013007787	Catalytic dyad [active]
635013007788	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
635013007789	Peptidase family M23; Region: Peptidase_M23; pfam01551
635013007790	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
635013007791	FtsX-like permease family; Region: FtsX; cl15850
635013007792	FtsX-like permease family; Region: FtsX; cl15850
635013007793	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
635013007794	FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane.  The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292
635013007795	Walker A/P-loop; other site
635013007796	ATP binding site [chemical binding]; other site
635013007797	Q-loop/lid; other site
635013007798	ABC transporter signature motif; other site
635013007799	Walker B; other site
635013007800	D-loop; other site
635013007801	H-loop/switch region; other site
635013007802	Helix-turn-helix domains; Region: HTH; cl00088
635013007803	putative transposase OrfB; Reviewed; Region: PHA02517
635013007804	Integrase core domain; Region: rve; cl01316
635013007805	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
635013007806	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
635013007807	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
635013007808	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013007809	active site
635013007810	phosphorylation site [posttranslational modification]
635013007811	intermolecular recognition site; other site
635013007812	dimerization interface [polypeptide binding]; other site
635013007813	LytTr DNA-binding domain; Region: LytTR; cl04498
635013007814	Accessory gene regulator B; Region: AgrB; cl01873
635013007815	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
635013007816	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013007817	ATP binding site [chemical binding]; other site
635013007818	Mg2+ binding site [ion binding]; other site
635013007819	G-X-G motif; other site
635013007820	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
635013007821	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
635013007822	PYR/PP interface [polypeptide binding]; other site
635013007823	dimer interface [polypeptide binding]; other site
635013007824	TPP binding site [chemical binding]; other site
635013007825	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
635013007826	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
635013007827	TPP-binding site [chemical binding]; other site
635013007828	dimer interface [polypeptide binding]; other site
635013007829	Uncharacterized conserved protein [Function unknown]; Region: COG1284
635013007830	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
635013007831	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
635013007832	peptide chain release factor 2; Validated; Region: prfB; PRK00578
635013007833	RF-1 domain; Region: RF-1; cl02875
635013007834	RF-1 domain; Region: RF-1; cl02875
635013007835	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
635013007836	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
635013007837	flagellar motor protein MotD; Reviewed; Region: PRK09038
635013007838	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
635013007839	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
635013007840	ligand binding site [chemical binding]; other site
635013007841	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
635013007842	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
635013007843	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007844	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
635013007845	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013007846	nucleotide binding region [chemical binding]; other site
635013007847	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013007848	Zn2+ binding site [ion binding]; other site
635013007849	Mg2+ binding site [ion binding]; other site
635013007850	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
635013007851	Zn2+ binding site [ion binding]; other site
635013007852	Mg2+ binding site [ion binding]; other site
635013007853	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
635013007854	30S subunit binding site; other site
635013007855	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
635013007856	DNA-binding site [nucleotide binding]; DNA binding site
635013007857	RNA-binding motif; other site
635013007858	Flagellar protein FliS; Region: FliS; cl00654
635013007859	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
635013007860	NeuB family; Region: NeuB; cl00496
635013007861	SAF domain; Region: SAF; cl00555
635013007862	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
635013007863	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
635013007864	putative trimer interface [polypeptide binding]; other site
635013007865	putative CoA binding site [chemical binding]; other site
635013007866	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
635013007867	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
635013007868	inhibitor-cofactor binding pocket; inhibition site
635013007869	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013007870	catalytic residue [active]
635013007871	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
635013007872	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
635013007873	NAD binding site [chemical binding]; other site
635013007874	substrate binding site [chemical binding]; other site
635013007875	active site
635013007876	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
635013007877	ligand binding site; other site
635013007878	tetramer interface; other site
635013007879	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
635013007880	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
635013007881	Substrate binding site; other site
635013007882	metal-binding site
635013007883	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
635013007884	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
635013007885	active site
635013007886	homodimer interface [polypeptide binding]; other site
635013007887	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
635013007888	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2604
635013007889	Helix-turn-helix domains; Region: HTH; cl00088
635013007890	flagellar capping protein; Validated; Region: fliD; PRK07737
635013007891	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
635013007892	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
635013007893	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
635013007894	FlaG protein; Region: FlaG; cl00591
635013007895	flagellin; Provisional; Region: PRK12804
635013007896	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
635013007897	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
635013007898	Global regulator protein family; Region: CsrA; cl00670
635013007899	FliW protein; Region: FliW; cl00740
635013007900	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
635013007901	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
635013007902	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
635013007903	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
635013007904	FlgN protein; Region: FlgN; cl09176
635013007905	Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052
635013007906	flagellar operon protein TIGR03826; Region: YvyF
635013007907	Haem utilisation ChuX/HutX; Region: ChuX_HutX; cl01509
635013007908	DNA utilization protein GntX; Provisional; Region: PRK11595
635013007909	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013007910	active site
635013007911	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
635013007912	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
635013007913	ATP binding site [chemical binding]; other site
635013007914	putative Mg++ binding site [ion binding]; other site
635013007915	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
635013007916	nucleotide binding region [chemical binding]; other site
635013007917	ATP-binding site [chemical binding]; other site
635013007918	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
635013007919	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013007920	metal binding site [ion binding]; metal-binding site
635013007921	active site
635013007922	I-site; other site
635013007923	GAF domain; Region: GAF_2; pfam13185
635013007924	GAF domain; Region: GAF; cl15785
635013007925	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
635013007926	metal binding site [ion binding]; metal-binding site
635013007927	active site
635013007928	I-site; other site
635013007929	Uncharacterized ACR, COG1430; Region: DUF192; cl00627
635013007930	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013007931	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
635013007932	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
635013007933	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
635013007934	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
635013007935	ATP binding site [chemical binding]; other site
635013007936	Walker A motif; other site
635013007937	hexamer interface [polypeptide binding]; other site
635013007938	Walker B motif; other site
635013007939	Response regulator receiver domain; Region: Response_reg; pfam00072
635013007940	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013007941	active site
635013007942	phosphorylation site [posttranslational modification]
635013007943	intermolecular recognition site; other site
635013007944	dimerization interface [polypeptide binding]; other site
635013007945	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
635013007946	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007947	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013007948	SAF domain; Region: SAF; cl00555
635013007949	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
635013007950	TadE-like protein; Region: TadE; cl10688
635013007951	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
635013007952	Type IV leader peptidase family; Region: Peptidase_A24; cl02077
635013007953	Flp/Fap pilin component; Region: Flp_Fap; cl01585
635013007954	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
635013007955	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
635013007956	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013007957	active site
635013007958	phosphorylation site [posttranslational modification]
635013007959	intermolecular recognition site; other site
635013007960	dimerization interface [polypeptide binding]; other site
635013007961	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
635013007962	DNA binding residues [nucleotide binding]
635013007963	dimerization interface [polypeptide binding]; other site
635013007964	Sensor protein DegS; Region: DegS; pfam05384
635013007965	Histidine kinase; Region: HisKA_3; pfam07730
635013007966	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013007967	ATP binding site [chemical binding]; other site
635013007968	Mg2+ binding site [ion binding]; other site
635013007969	G-X-G motif; other site
635013007970	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
635013007971	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
635013007972	active site
635013007973	substrate binding site [chemical binding]; other site
635013007974	metal binding site [ion binding]; metal-binding site
635013007975	Protein of unknown function (DUF421); Region: DUF421; cl00990
635013007976	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
635013007977	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
635013007978	Mg++ binding site [ion binding]; other site
635013007979	putative catalytic motif [active]
635013007980	substrate binding site [chemical binding]; other site
635013007981	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
635013007982	integral membrane protein MviN; Region: mviN; TIGR01695
635013007983	MatE; Region: MatE; cl10513
635013007984	This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807
635013007985	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
635013007986	putative ADP-binding pocket [chemical binding]; other site
635013007987	S-layer homology domain; Region: SLH; pfam00395
635013007988	S-layer homology domain; Region: SLH; pfam00395
635013007989	S-layer homology domain; Region: SLH; pfam00395
635013007990	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
635013007991	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
635013007992	cytoskeletal protein RodZ; Provisional; Region: PRK10856
635013007993	S-layer homology domain; Region: SLH; pfam00395
635013007994	S-layer homology domain; Region: SLH; pfam00395
635013007995	S-layer homology domain; Region: SLH; pfam00395
635013007996	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
635013007997	active site
635013007998	catalytic residues [active]
635013007999	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
635013008000	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
635013008001	Substrate binding site; other site
635013008002	Cupin domain; Region: Cupin_2; cl09118
635013008003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
635013008004	Helix-turn-helix domains; Region: HTH; cl00088
635013008005	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
635013008006	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
635013008007	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
635013008008	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013008009	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
635013008010	Uncharacterized membrane protein, required for N-linked glycosylation [General function prediction only]; Region: COG1287
635013008011	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
635013008012	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
635013008013	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013008014	NAD(P) binding site [chemical binding]; other site
635013008015	active site
635013008016	Predicted integral membrane protein [Function unknown]; Region: COG0392
635013008017	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
635013008018	Uncharacterized conserved protein [Function unknown]; Region: COG2006
635013008019	Domain of unknown function (DUF362); Region: DUF362; pfam04015
635013008020	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013008021	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013008022	UbiA prenyltransferase family; Region: UbiA; cl00337
635013008023	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
635013008024	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013008025	Bacterial sugar transferase; Region: Bac_transf; cl00939
635013008026	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
635013008027	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
635013008028	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
635013008029	putative ADP-binding pocket [chemical binding]; other site
635013008030	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
635013008031	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
635013008032	O-Antigen ligase; Region: Wzy_C; cl04850
635013008033	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
635013008034	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
635013008035	putative metal binding site; other site
635013008036	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
635013008037	putative homodimer interface [polypeptide binding]; other site
635013008038	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013008039	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
635013008040	MatE; Region: MatE; cl10513
635013008041	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
635013008042	Sulfatase; Region: Sulfatase; cl10460
635013008043	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
635013008044	active site
635013008045	Substrate binding site; other site
635013008046	Mg++ binding site; other site
635013008047	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
635013008048	O-Antigen ligase; Region: Wzy_C; cl04850
635013008049	TPR repeat; Region: TPR_11; pfam13414
635013008050	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013008051	TPR motif; other site
635013008052	binding surface
635013008053	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
635013008054	TM-ABC transporter signature motif; other site
635013008055	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
635013008056	The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine.  MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219
635013008057	Walker A/P-loop; other site
635013008058	ATP binding site [chemical binding]; other site
635013008059	Q-loop/lid; other site
635013008060	ABC transporter signature motif; other site
635013008061	Walker B; other site
635013008062	D-loop; other site
635013008063	H-loop/switch region; other site
635013008064	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013008065	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013008066	Radical SAM superfamily; Region: Radical_SAM; pfam04055
635013008067	FeS/SAM binding site; other site
635013008068	AMP-binding enzyme; Region: AMP-binding; cl15778
635013008069	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
635013008070	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
635013008071	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013008072	FeS/SAM binding site; other site
635013008073	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
635013008074	Bacterial Ig-like domain; Region: Big_5; cl01012
635013008075	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
635013008076	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
635013008077	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
635013008078	Bacterial Ig-like domain; Region: Big_5; cl01012
635013008079	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
635013008080	Bacterial Ig-like domain; Region: Big_5; cl01012
635013008081	Bacterial Ig-like domain; Region: Big_5; cl01012
635013008082	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
635013008083	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
635013008084	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
635013008085	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
635013008086	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
635013008087	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
635013008088	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
635013008089	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
635013008090	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
635013008091	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
635013008092	Bacterial Ig-like domain; Region: Big_5; cl01012
635013008093	Bacterial Ig-like domain; Region: Big_5; cl01012
635013008094	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
635013008095	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
635013008096	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
635013008097	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
635013008098	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
635013008099	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
635013008100	S-layer homology domain; Region: SLH; pfam00395
635013008101	S-layer homology domain; Region: SLH; pfam00395
635013008102	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
635013008103	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
635013008104	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
635013008105	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
635013008106	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013008107	Interdomain contacts; other site
635013008108	Cytokine receptor motif; other site
635013008109	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008110	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013008111	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008112	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
635013008113	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
635013008114	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013008115	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013008116	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008117	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013008118	Interdomain contacts; other site
635013008119	Cytokine receptor motif; other site
635013008120	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013008121	Interdomain contacts; other site
635013008122	Cytokine receptor motif; other site
635013008123	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013008124	Interdomain contacts; other site
635013008125	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013008126	Cytokine receptor motif; other site
635013008127	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008128	decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508
635013008129	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008130	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008131	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008132	Fibrillarin-like archaeal protein; Region: Fibrillarin_2; pfam10113
635013008133	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013008134	Interdomain contacts; other site
635013008135	Cytokine receptor motif; other site
635013008136	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
635013008137	Interdomain contacts; other site
635013008138	Cytokine receptor motif; other site
635013008139	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
635013008140	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
635013008141	NHL repeat; Region: NHL; pfam01436
635013008142	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013008143	NHL repeat; Region: NHL; pfam01436
635013008144	NHL repeat; Region: NHL; pfam01436
635013008145	NHL repeat; Region: NHL; pfam01436
635013008146	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008147	Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905
635013008148	NHL repeat; Region: NHL; pfam01436
635013008149	Uncharacterized conserved protein [Function unknown]; Region: COG3391
635013008150	NHL repeat; Region: NHL; pfam01436
635013008151	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
635013008152	binding surface
635013008153	TPR repeat; Region: TPR_11; pfam13414
635013008154	TPR motif; other site
635013008155	TPR repeat; Region: TPR_11; pfam13414
635013008156	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
635013008157	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
635013008158	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
635013008159	putative active site [active]
635013008160	putative metal binding site [ion binding]; other site
635013008161	SurA N-terminal domain; Region: SurA_N_3; cl07813
635013008162	S-layer homology domain; Region: SLH; pfam00395
635013008163	S-layer homology domain; Region: SLH; pfam00395
635013008164	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
635013008165	active site
635013008166	NTP binding site [chemical binding]; other site
635013008167	metal binding triad [ion binding]; metal-binding site
635013008168	antibiotic binding site [chemical binding]; other site
635013008169	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
635013008170	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
635013008171	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
635013008172	S-layer homology domain; Region: SLH; pfam00395
635013008173	S-layer homology domain; Region: SLH; pfam00395
635013008174	S-layer homology domain; Region: SLH; pfam00395
635013008175	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
635013008176	Rod binding protein; Region: Rod-binding; cl01626
635013008177	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
635013008178	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
635013008179	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12816
635013008180	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
635013008181	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
635013008182	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
635013008183	rod shape-determining protein Mbl; Provisional; Region: PRK13928
635013008184	Cell division protein FtsA; Region: FtsA; cl11496
635013008185	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
635013008186	stage II sporulation protein D; Region: spore_II_D; TIGR02870
635013008187	Stage II sporulation protein; Region: SpoIID; pfam08486
635013008188	ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033
635013008189	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
635013008190	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
635013008191	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
635013008192	alpha subunit interaction interface [polypeptide binding]; other site
635013008193	Walker A motif; other site
635013008194	ATP binding site [chemical binding]; other site
635013008195	Walker B motif; other site
635013008196	inhibitor binding site; inhibition site
635013008197	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
635013008198	ATP synthase; Region: ATP-synt; cl00365
635013008199	F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422
635013008200	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
635013008201	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
635013008202	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
635013008203	beta subunit interaction interface [polypeptide binding]; other site
635013008204	Walker A motif; other site
635013008205	ATP binding site [chemical binding]; other site
635013008206	Walker B motif; other site
635013008207	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
635013008208	Plant ATP synthase F0; Region: YMF19; cl07975
635013008209	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
635013008210	Plant ATP synthase F0; Region: YMF19; cl07975
635013008211	ATP synthase subunit C; Region: ATP-synt_C; cl00466
635013008212	ATP synthase A chain; Region: ATP-synt_A; cl00413
635013008213	ATP synthase I chain; Region: ATP_synt_I; cl09170
635013008214	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754
635013008215	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
635013008216	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
635013008217	active site
635013008218	homodimer interface [polypeptide binding]; other site
635013008219	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
635013008220	catalytic motif [active]
635013008221	Zn binding site [ion binding]; other site
635013008222	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
635013008223	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
635013008224	dimer interface [polypeptide binding]; other site
635013008225	glycine-pyridoxal phosphate binding site [chemical binding]; other site
635013008226	active site
635013008227	folate binding site [chemical binding]; other site
635013008228	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
635013008229	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
635013008230	Low molecular weight phosphatase family; Region: LMWPc; cd00115
635013008231	active site
635013008232	Domain of unknown function DUF; Region: DUF204; pfam02659
635013008233	Domain of unknown function DUF; Region: DUF204; pfam02659
635013008234	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
635013008235	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
635013008236	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
635013008237	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
635013008238	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
635013008239	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013008240	peptide chain release factor 1; Validated; Region: prfA; PRK00591
635013008241	RF-1 domain; Region: RF-1; cl02875
635013008242	RF-1 domain; Region: RF-1; cl02875
635013008243	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
635013008244	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
635013008245	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013008246	Radical SAM superfamily; Region: Radical_SAM; pfam04055
635013008247	FeS/SAM binding site; other site
635013008248	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
635013008249	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013008250	putative peptidoglycan binding site; other site
635013008251	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
635013008252	putative peptidoglycan binding site; other site
635013008253	Peptidase family M23; Region: Peptidase_M23; pfam01551
635013008254	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
635013008255	OpgC protein; Region: OpgC_C; cl00792
635013008256	Acyltransferase family; Region: Acyl_transf_3; pfam01757
635013008257	transcription termination factor Rho; Provisional; Region: rho; PRK09376
635013008258	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
635013008259	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
635013008260	RNA binding site [nucleotide binding]; other site
635013008261	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
635013008262	multimer interface [polypeptide binding]; other site
635013008263	Walker A motif; other site
635013008264	ATP binding site [chemical binding]; other site
635013008265	Walker B motif; other site
635013008266	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
635013008267	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
635013008268	putative active site [active]
635013008269	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
635013008270	active site
635013008271	intersubunit interactions; other site
635013008272	catalytic residue [active]
635013008273	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
635013008274	hypothetical protein; Provisional; Region: PRK08185
635013008275	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
635013008276	intersubunit interface [polypeptide binding]; other site
635013008277	active site
635013008278	zinc binding site [ion binding]; other site
635013008279	Na+ binding site [ion binding]; other site
635013008280	Response regulator receiver domain; Region: Response_reg; pfam00072
635013008281	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
635013008282	active site
635013008283	phosphorylation site [posttranslational modification]
635013008284	intermolecular recognition site; other site
635013008285	dimerization interface [polypeptide binding]; other site
635013008286	Yip1 domain; Region: Yip1; cl12048
635013008287	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
635013008288	tandem repeat interface [polypeptide binding]; other site
635013008289	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
635013008290	oligomer interface [polypeptide binding]; other site
635013008291	active site residues [active]
635013008292	CTP synthetase; Validated; Region: pyrG; PRK05380
635013008293	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
635013008294	Catalytic site [active]
635013008295	active site
635013008296	UTP binding site [chemical binding]; other site
635013008297	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
635013008298	active site
635013008299	putative oxyanion hole; other site
635013008300	catalytic triad [active]
635013008301	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; cl01319
635013008302	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
635013008303	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
635013008304	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
635013008305	active site
635013008306	HIGH motif; other site
635013008307	KMSK motif region; other site
635013008308	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
635013008309	tRNA binding surface [nucleotide binding]; other site
635013008310	anticodon binding site; other site
635013008311	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
635013008312	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
635013008313	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
635013008314	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
635013008315	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
635013008316	dimer interface [polypeptide binding]; other site
635013008317	PYR/PP interface [polypeptide binding]; other site
635013008318	TPP binding site [chemical binding]; other site
635013008319	substrate binding site [chemical binding]; other site
635013008320	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
635013008321	TPP-binding site; other site
635013008322	4Fe-4S binding domain; Region: Fer4; cl02805
635013008323	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
635013008324	AMP-binding enzyme; Region: AMP-binding; cl15778
635013008325	Sodium:solute symporter family; Region: SSF; cl00456
635013008326	hypothetical protein; Validated; Region: PRK07682
635013008327	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
635013008328	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013008329	homodimer interface [polypeptide binding]; other site
635013008330	catalytic residue [active]
635013008331	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
635013008332	Helix-turn-helix domains; Region: HTH; cl00088
635013008333	Helix-turn-helix domains; Region: HTH; cl00088
635013008334	Transposase domain (DUF772); Region: DUF772; cl15789
635013008335	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013008336	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
635013008337	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
635013008338	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
635013008339	metal-binding site [ion binding]
635013008340	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
635013008341	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
635013008342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
635013008343	phosphorylation site [posttranslational modification]
635013008344	dimer interface [polypeptide binding]; other site
635013008345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
635013008346	ATP binding site [chemical binding]; other site
635013008347	Mg2+ binding site [ion binding]; other site
635013008348	G-X-G motif; other site
635013008349	Transglycosylase; Region: Transgly; cl07896
635013008350	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
635013008351	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
635013008352	germination protein YpeB; Region: spore_YpeB; TIGR02889
635013008353	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
635013008354	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
635013008355	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
635013008356	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
635013008357	Ferritin-like domain; Region: Ferritin; pfam00210
635013008358	dinuclear metal binding motif [ion binding]; other site
635013008359	hydroxylamine reductase; Provisional; Region: PRK12310
635013008360	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
635013008361	cubane metal cluster [ion binding]; other site
635013008362	hybrid metal cluster; other site
635013008363	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013008364	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
635013008365	B12 binding site [chemical binding]; other site
635013008366	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
635013008367	BCCT family transporter; Region: BCCT; cl00569
635013008368	tetrahydromethanopterin S-methyltransferase subunit H; Provisional; Region: PRK00979
635013008369	Tetrahydromethanopterin S-methyltransferase, subunit H [Coenzyme metabolism]; Region: MtrH; cl15798
635013008370	BCCT family transporter; Region: BCCT; cl00569
635013008371	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
635013008372	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
635013008373	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
635013008374	B12 binding site [chemical binding]; other site
635013008375	cobalt ligand [ion binding]; other site
635013008376	Sensory domain found in PocR; Region: PocR; pfam10114
635013008377	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
635013008378	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
635013008379	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
635013008380	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
635013008381	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
635013008382	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013008383	NAD(P) binding site [chemical binding]; other site
635013008384	active site
635013008385	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
635013008386	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013008387	FeS/SAM binding site; other site
635013008388	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
635013008389	Protein of unknown function (DUF4001); Region: DUF4001; cl14848
635013008390	Transposase domain (DUF772); Region: DUF772; cl15789
635013008391	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
635013008392	HupF/HypC family; Region: HupF_HypC; cl00394
635013008393	Hydrogenase formation hypA family; Region: HypD; cl12072
635013008394	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409
635013008395	CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640
635013008396	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
635013008397	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
635013008398	carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702
635013008399	Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915
635013008400	ACS interaction site; other site
635013008401	CODH interaction site; other site
635013008402	cubane metal cluster (B-cluster) [ion binding]; other site
635013008403	Ni-Fe-S cluster (C-cluster) [ion binding]; other site
635013008404	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
635013008405	4Fe-4S binding domain; Region: Fer4; cl02805
635013008406	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
635013008407	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
635013008408	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
635013008409	Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346
635013008410	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15771
635013008411	formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387
635013008412	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
635013008413	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
635013008414	NADH dehydrogenase; Region: NADHdh; cl00469
635013008415	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
635013008416	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12663
635013008417	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
635013008418	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
635013008419	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
635013008420	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
635013008421	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
635013008422	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
635013008423	ligand binding site [chemical binding]; other site
635013008424	flexible hinge region; other site
635013008425	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
635013008426	putative switch regulator; other site
635013008427	non-specific DNA interactions [nucleotide binding]; other site
635013008428	DNA binding site [nucleotide binding]
635013008429	sequence specific DNA binding site [nucleotide binding]; other site
635013008430	putative cAMP binding site [chemical binding]; other site
635013008431	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
635013008432	homodimer interface [polypeptide binding]; other site
635013008433	substrate-cofactor binding pocket; other site
635013008434	pyridoxal 5'-phosphate binding site [chemical binding]; other site
635013008435	catalytic residue [active]
635013008436	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
635013008437	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
635013008438	chorismate binding enzyme; Region: Chorismate_bind; cl10555
635013008439	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
635013008440	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
635013008441	GDP-binding site [chemical binding]; other site
635013008442	ACT binding site; other site
635013008443	IMP binding site; other site
635013008444	replicative DNA helicase; Region: DnaB; TIGR00665
635013008445	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
635013008446	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
635013008447	Walker A motif; other site
635013008448	ATP binding site [chemical binding]; other site
635013008449	Walker B motif; other site
635013008450	DNA binding loops [nucleotide binding]
635013008451	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
635013008452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013008453	Walker A motif; other site
635013008454	ATP binding site [chemical binding]; other site
635013008455	Walker B motif; other site
635013008456	arginine finger; other site
635013008457	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
635013008458	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
635013008459	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
635013008460	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
635013008461	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
635013008462	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
635013008463	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
635013008464	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
635013008465	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
635013008466	dimer interface [polypeptide binding]; other site
635013008467	ssDNA binding site [nucleotide binding]; other site
635013008468	tetramer (dimer of dimers) interface [polypeptide binding]; other site
635013008469	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
635013008470	GTP-binding protein YchF; Reviewed; Region: PRK09601
635013008471	YchF GTPase; Region: YchF; cd01900
635013008472	G1 box; other site
635013008473	GTP/Mg2+ binding site [chemical binding]; other site
635013008474	Switch I region; other site
635013008475	G2 box; other site
635013008476	Switch II region; other site
635013008477	G3 box; other site
635013008478	G4 box; other site
635013008479	G5 box; other site
635013008480	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
635013008481	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
635013008482	Mechanosensitive ion channel; Region: MS_channel; pfam00924
635013008483	putative oxidoreductase/HEAT repeat-containing protein; Provisional; Region: PRK13800
635013008484	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
635013008485	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
635013008486	oligomer interface [polypeptide binding]; other site
635013008487	putative active site [active]
635013008488	metal binding site [ion binding]; metal-binding site
635013008489	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
635013008490	G1 box; other site
635013008491	GTP/Mg2+ binding site [chemical binding]; other site
635013008492	Switch I region; other site
635013008493	G3 box; other site
635013008494	Switch II region; other site
635013008495	G4 box; other site
635013008496	G5 box; other site
635013008497	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
635013008498	hydrogenase nickel incorporation protein; Provisional; Region: hypA; cl00418
635013008499	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
635013008500	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
635013008501	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417
635013008502	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
635013008503	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792
635013008504	4Fe-4S binding domain; Region: Fer4; cl02805
635013008505	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
635013008506	4Fe-4S binding domain; Region: Fer4; cl02805
635013008507	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
635013008508	Predicted Fe-S protein [General function prediction only]; Region: COG2000
635013008509	Putative Fe-S cluster; Region: FeS; pfam04060
635013008510	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
635013008511	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
635013008512	Walker A motif; other site
635013008513	ATP binding site [chemical binding]; other site
635013008514	Walker B motif; other site
635013008515	arginine finger; other site
635013008516	Helix-turn-helix domains; Region: HTH; cl00088
635013008517	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
635013008518	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
635013008519	active site
635013008520	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
635013008521	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
635013008522	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
635013008523	Ligand Binding Site [chemical binding]; other site
635013008524	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
635013008525	AIR carboxylase; Region: AIRC; cl00310
635013008526	Protein of unknown function DUF111; Region: DUF111; cl03398
635013008527	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
635013008528	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
635013008529	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
635013008530	catalytic residue [active]
635013008531	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
635013008532	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
635013008533	G1 box; other site
635013008534	GTP/Mg2+ binding site [chemical binding]; other site
635013008535	Switch I region; other site
635013008536	G2 box; other site
635013008537	Switch II region; other site
635013008538	G3 box; other site
635013008539	G4 box; other site
635013008540	G5 box; other site
635013008541	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
635013008542	biotin synthase; Provisional; Region: PRK07094
635013008543	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013008544	FeS/SAM binding site; other site
635013008545	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
635013008546	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
635013008547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
635013008548	FeS/SAM binding site; other site
635013008549	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
635013008550	ParB-like partition proteins; Region: parB_part; TIGR00180
635013008551	ParB-like nuclease domain; Region: ParBc; cl02129
635013008552	KorB domain; Region: KorB; pfam08535
635013008553	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
635013008554	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
635013008555	P-loop; other site
635013008556	Magnesium ion binding site [ion binding]; other site
635013008557	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
635013008558	Magnesium ion binding site [ion binding]; other site
635013008559	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
635013008560	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
635013008561	S-adenosylmethionine binding site [chemical binding]; other site
635013008562	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
635013008563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
635013008564	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
635013008565	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
635013008566	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
635013008567	trmE is a tRNA modification GTPase; Region: trmE; cd04164
635013008568	G1 box; other site
635013008569	GTP/Mg2+ binding site [chemical binding]; other site
635013008570	Switch I region; other site
635013008571	G2 box; other site
635013008572	Switch II region; other site
635013008573	G3 box; other site
635013008574	G4 box; other site
635013008575	G5 box; other site
635013008576	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
635013008577	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
635013008578	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
635013008579	G-X-X-G motif; other site
635013008580	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
635013008581	RxxxH motif; other site
635013008582	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
635013008583	Haemolytic domain; Region: Haemolytic; cl00506
635013008584	Ribonuclease P; Region: Ribonuclease_P; cl00457
635013008585	Ribosomal protein L34; Region: Ribosomal_L34; cl00370