-- dump date 20120504_163917 -- class Genbank::CDS -- table cds_note -- id note YP_001661661.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_001661662.1 binds the polymerase to DNA and acts as a sliding clamp YP_001661663.1 PFAM: RNA-binding S4 domain protein YP_001661664.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_001661666.1 PFAM: glycoside hydrolase, family 31 YP_001661667.1 PFAM: CobB/CobQ domain protein glutamine amidotransferase YP_001661668.1 PFAM: Mur ligase, middle domain protein; domain of unknown function DUF1727 YP_001661669.1 negatively supercoils closed circular double-stranded DNA YP_001661670.1 TIGRFAM: DNA gyrase, A subunit; PFAM: DNA gyrase/topoisomerase IV, subunit A; DNA gyrase C-terminal repeat, beta-propeller YP_001661671.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase YP_001661672.1 TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein YP_001661673.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_001661674.1 PFAM: pyruvate carboxyltransferase YP_001661675.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis YP_001661676.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis YP_001661677.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_001661678.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_001661679.1 TIGRFAM: acetolactate synthase, large subunit, biosynthetic type; PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding; thiamine pyrophosphate enzyme, central region; thiamine pyrophosphate enzyme TPP binding domain protein YP_001661680.1 TIGRFAM: riboflavin biosynthesis protein RibD; PFAM: CMP/dCMP deaminase, zinc-binding; bifunctional deaminase-reductase domain protein YP_001661681.1 TIGRFAM: riboflavin synthase, alpha subunit; PFAM: Lumazine-binding protein YP_001661682.1 PFAM: 3,4-dihydroxy-2-butanone 4-phosphate synthase; GTP cyclohydrolase II YP_001661683.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_001661684.1 PFAM: protein of unknown function UPF0118 YP_001661685.1 TIGRFAM: transposase, putative; transposase, IS605 OrfB family YP_001661687.1 TIGRFAM: signal peptidase I; PFAM: peptidase S24, S26A and S26B YP_001661688.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001661689.1 PFAM: lipolytic enzyme, G-D-S-L family YP_001661690.1 PFAM: CMP/dCMP deaminase, zinc-binding YP_001661691.1 TIGRFAM: PAS sensor protein; PFAM: histidine kinase, HAMP region domain protein; metal-dependent phosphohydrolase, HD sub domain; PAS fold-3 domain protein; PAS fold domain protein; HDOD; SMART: PAS domain containing protein; metal-dependent phosphohydrolase, HD region YP_001661692.1 TIGRFAM: DNA polymerase III, subunits gamma and tau; PFAM: AAA ATPase, central domain protein; DNA polymerase III, delta; SMART: AAA ATPase YP_001661693.1 PFAM: conserved hypothetical protein 103 YP_001661694.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_001661695.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein YP_001661696.1 TIGRFAM: CrcB protein; PFAM: Camphor resistance CrcB protein YP_001661697.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001661699.1 PFAM: sigmaK-factor processing regulatory BofA YP_001661703.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001661704.1 PFAM: protein of unknown function DUF395, YeeE/YedE YP_001661705.1 PFAM: SirA family protein YP_001661706.1 PFAM: protein of unknown function DUF395, YeeE/YedE YP_001661707.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; HI0933 family protein YP_001661708.1 TIGRFAM: putative glucokinase, ROK family; PFAM: ROK family protein YP_001661709.1 PFAM: methyladenine glycosylase YP_001661711.1 PFAM: aminotransferase, class V; Orn/Lys/Arg decarboxylase, major region; aminotransferase, class I and II; Orn/Lys/Arg decarboxylase domain protein YP_001661712.1 PFAM: thymidylate kinase YP_001661713.1 PFAM: protein of unknown function DUF970 YP_001661714.1 PFAM: protein of unknown function DUF327 YP_001661715.1 TIGRFAM: DNA polymerase III, delta prime subunit YP_001661716.1 PFAM: PSP1 domain protein YP_001661717.1 PFAM: amidinotransferase YP_001661718.1 PFAM: putative RNA methylase; methyltransferase small YP_001661719.1 PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001661720.1 TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein YP_001661721.1 PFAM: nucleoside recognition domain protein YP_001661722.1 PFAM: nucleoside recognition domain protein YP_001661723.1 TIGRFAM: metal dependent phophohydrolase; PFAM: Polynucleotide adenylyltransferase region; metal-dependent phosphohydrolase, HD sub domain YP_001661724.1 TIGRFAM: methionyl-tRNA synthetase; methionyl-tRNA synthetase, beta subunit; PFAM: t-RNA-binding domain protein; Methionyl-tRNA synthetase, beta subunit domain protein YP_001661725.1 TIGRFAM: hydrolase, TatD family; PFAM: TatD-related deoxyribonuclease YP_001661726.1 PFAM: protein of unknown function DUF348; 3D domain protein; G5 domain protein YP_001661727.1 TIGRFAM: dimethyladenosine transferase; PFAM: ribosomal RNA adenine methylase transferase YP_001661732.1 Heat shock-induced YP_001661733.1 PFAM: protein of unknown function DUF59 YP_001661736.1 PFAM: peptidase M41; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001661737.1 TIGRFAM: electron transport complex, RnfABCDGE type, C subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001661738.1 TIGRFAM: electron transport complex, RnfABCDGE type, D subunit; PFAM: NQR2 and RnfD family protein YP_001661739.1 TIGRFAM: electron transport complex, RnfABCDGE type, G subunit; PFAM: FMN-binding domain protein YP_001661740.1 TIGRFAM: electron transport complex, RnfABCDGE type, E subunit; PFAM: RnfA-Nqr electron transport subunit YP_001661741.1 TIGRFAM: electron transport complex, RnfABCDGE type, A subunit; PFAM: RnfA-Nqr electron transport subunit YP_001661742.1 TIGRFAM: electron transport complex, RnfABCDGE type, B subunit; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Fe-S cluster domain protein YP_001661743.1 PFAM: protein of unknown function DUF1312 YP_001661745.1 PFAM: response regulator receiver YP_001661746.1 class II aldolase; catalyzes the formation of fructose 1,6-bisphosphate from dihydroxyacetone phosphate and glyceraldehyde 3-phosphate YP_001661747.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_001661748.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_001661749.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_001661750.1 PFAM: protein of unknown function DUF1385 YP_001661751.1 TIGRFAM: modification methylase, HemK family; PFAM: putative RNA methylase; methyltransferase small YP_001661752.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_001661753.1 PFAM: zinc/iron permease YP_001661754.1 TIGRFAM: Sua5/YciO/YrdC/YwlC family protein; PFAM: SUA5 domain protein; SUA5/yciO/yrdC, N-terminal domain YP_001661755.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001661756.1 TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase YP_001661757.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_001661758.1 PFAM: CMP/dCMP deaminase, zinc-binding YP_001661761.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001661762.1 TIGRFAM: alanine dehydrogenase; PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; alanine dehydrogenase/PNT domain protein YP_001661763.1 PFAM: pyruvate phosphate dikinase, PEP/pyruvate-binding YP_001661764.1 TIGRFAM: SpoIID/LytB domain; PFAM: Stage II sporulation D domain protein YP_001661765.1 PFAM: peptidase M23B YP_001661766.1 TIGRFAM: regulatory protein, DeoR YP_001661767.1 TIGRFAM: cell shape determining protein, MreB/Mrl family; PFAM: cell division protein FtsA; cell shape determining protein MreB/Mrl YP_001661768.1 PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001661769.1 PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001661771.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_001661772.1 TIGRFAM: integral membrane protein MviN; PFAM: multi antimicrobial extrusion protein MatE; polysaccharide biosynthesis protein; virulence factor MVIN family protein YP_001661773.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001661775.1 PFAM: protein of unknown function DUF152 YP_001661776.1 TIGRFAM: prevent-host-death family protein YP_001661778.1 PFAM: sigma-54 factor, interaction domain-containing protein; phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; PTS system fructose subfamily IIA component; PRD domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001661779.1 PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 YP_001661780.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit YP_001661781.1 PFAM: PTS system Galactitol-specific IIC component YP_001661782.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001661783.1 PFAM: SAF domain YP_001661784.1 PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein YP_001661785.1 PFAM: Mandelate racemase/muconate lactonizing enzyme, N-terminal domain protein; Mandelate racemase/muconate lactonizing enzyme, C-terminal domain protein YP_001661786.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001661787.1 TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase YP_001661788.1 PFAM: major facilitator superfamily MFS_1 YP_001661789.1 PFAM: sigma-54 factor, interaction domain-containing protein; PTS system fructose subfamily IIA component; PRD domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001661790.1 PFAM: PTS system fructose subfamily IIA component YP_001661791.1 PFAM: phosphotransferase system PTS, sorbose-specific IIC subunit YP_001661792.1 PFAM: PTS system mannose/fructose/sorbose family IID component YP_001661793.1 PFAM: PTS system sorbose subfamily IIB component YP_001661794.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001661795.1 TIGRFAM: 2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase; PFAM: KDPG and KHG aldolase; thiamine monophosphate synthase YP_001661796.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001661797.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001661798.1 TIGRFAM: potassium uptake protein, TrkH family; PFAM: cation transporter YP_001661799.1 PFAM: TrkA-N domain protein; TrkA-C domain protein YP_001661801.1 PFAM: nitroreductase YP_001661802.1 PFAM: iron-containing alcohol dehydrogenase YP_001661803.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001661804.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001661805.1 PFAM: transposase IS116/IS110/IS902 family protein YP_001661808.1 TIGRFAM: xylose isomerase; PFAM: Xylose isomerase domain protein TIM barrel YP_001661809.1 TIGRFAM: xylulokinase; PFAM: carbohydrate kinase, FGGY YP_001661810.1 TIGRFAM: D-xylose ABC transporter, periplasmic substrate-binding protein; PFAM: periplasmic binding protein/LacI transcriptional regulator YP_001661811.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001661812.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661813.1 PFAM: inner-membrane translocator YP_001661814.1 PFAM: ROK family protein YP_001661815.1 PFAM: oxidoreductase domain protein YP_001661816.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001661817.1 TIGRFAM: ribokinase; PFAM: PfkB domain protein YP_001661818.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_001661819.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661820.1 PFAM: inner-membrane translocator YP_001661821.1 PFAM: periplasmic binding protein/LacI transcriptional regulator YP_001661822.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001661823.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS) YP_001661824.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; PFAM: sugar-specific permease, EIIA 1 domain YP_001661825.1 PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC YP_001661826.1 PFAM: protein of unknown function DUF871 YP_001661827.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_001661829.1 PFAM: PRD domain protein YP_001661833.1 PFAM: aryldialkylphosphatase YP_001661834.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes YP_001661836.1 PFAM: metalloenzyme domain protein; Phosphopentomutase N-terminal domain protein YP_001661837.1 PFAM: glycoside hydrolase, family 3 domain protein YP_001661838.1 PFAM: GCN5-related N-acetyltransferase YP_001661839.1 TIGRFAM: N-acetylglucosamine-6-phosphate deacetylase; PFAM: amidohydrolase; Amidohydrolase 3 YP_001661840.1 PFAM: aminotransferase, class I and II YP_001661841.1 PFAM: regulatory protein, AsnC/Lrp family YP_001661842.1 PFAM: FeoA family protein YP_001661843.1 TIGRFAM: ferrous iron transport protein B; small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Ferrous iron transport protein B domain protein; Ferrous iron transport B domain protein; nucleoside recognition domain protein YP_001661844.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661845.1 TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein YP_001661847.1 catalyzes the ATP-dependent transport of cobalt YP_001661848.1 Inhibits transcription at high concentrations of nickel YP_001661849.1 PFAM: tRNA/rRNA methyltransferase (SpoU) YP_001661850.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_001661851.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001661852.1 TIGRFAM: efflux transporter, RND family, MFP subunit; PFAM: biotin/lipoyl attachment domain-containing protein YP_001661853.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661854.1 PFAM: protein of unknown function DUF214 YP_001661855.1 PFAM: fumarylacetoacetate (FAA) hydrolase YP_001661857.1 TIGRFAM: UvrD-like DNA helicase, C terminal; PFAM: UvrD/REP helicase YP_001661858.1 TIGRFAM: nuclease SbcCD, D subunit; PFAM: metallophosphoesterase YP_001661859.1 PFAM: SMC domain protein YP_001661860.1 PFAM: aminotransferase, class V; Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001661861.1 alkyl hydroperoxidase; catalyze the reduction of hydrogen peroxide to water and the reduction of alkyl hydroperoxides to the corresponding alcohols YP_001661862.1 PFAM: ferric-uptake regulator YP_001661864.1 TIGRFAM: galactose-1-phosphate uridylyltransferase; PFAM: histidine triad (HIT) protein; galactose-1-phosphate uridyl transferase domain protein YP_001661866.1 TIGRFAM: glycogen synthase; PFAM: glycosyl transferase, group 1 YP_001661868.1 PFAM: protein of unknown function DUF881 YP_001661870.1 TIGRFAM: L-lactate dehydrogenase; PFAM: Lactate/malate dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase YP_001661874.1 PFAM: protein of unknown function DUF296 YP_001661876.1 PFAM: periplasmic binding protein/LacI transcriptional regulator YP_001661877.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase internal region YP_001661878.1 PFAM: helix-turn-helix- domain containing protein, AraC type; response regulator receiver YP_001661879.1 PFAM: periplasmic binding protein/LacI transcriptional regulator YP_001661881.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661882.1 PFAM: inner-membrane translocator YP_001661883.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 1 to form the P protein YP_001661884.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; forms a heterodimer with subunit 2 to form the P protein YP_001661885.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_001661886.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_001661887.1 TIGRFAM: lipoyltransferase and lipoate-protein ligase; PFAM: biotin/lipoate A/B protein ligase YP_001661888.1 TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: biotin/lipoyl attachment domain-containing protein; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase YP_001661889.1 PFAM: OsmC family protein YP_001661890.1 PFAM: aminotransferase, class I and II YP_001661891.1 PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; M trans-acting positive regulator; PRD domain protein; Helix-turn-helix, type 11 domain protein YP_001661892.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_001661893.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit YP_001661895.1 PFAM: iron-containing alcohol dehydrogenase YP_001661896.1 TIGRFAM: penicillin-binding protein, 1A family; PFAM: glycosyl transferase, family 51; penicillin-binding protein, transpeptidase YP_001661899.1 PFAM: regulatory protein, ArsR YP_001661900.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001661904.1 TIGRFAM: putative CoA-substrate-specific enzyme activase; PFAM: ATPase, BadF/BadG/BcrA/BcrD type YP_001661906.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001661907.1 PFAM: conserved hypothetical protein 245 YP_001661908.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_001661909.1 PFAM: AzlC family protein YP_001661910.1 PFAM: branched-chain amino acid transport YP_001661911.1 PFAM: LexA DNA-binding domain protein; PfkB domain protein; Helix-turn-helix, type 11 domain protein YP_001661912.1 PFAM: Indigoidine synthase A family protein YP_001661914.1 PFAM: sigma-54 factor, interaction domain-containing protein; PTS system fructose subfamily IIA component; PRD domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001661915.1 TIGRFAM: PTS system, lactose/cellobiose family IIC subunit; PTS system, cellobiose-specific IIC subunit; PFAM: phosphotransferase system, EIIC YP_001661916.1 PFAM: YdjC family protein YP_001661917.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit YP_001661918.1 PFAM: phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit YP_001661919.1 PFAM: glycoside hydrolase, family 4 YP_001661920.1 PFAM: glycoside hydrolase, family 1 YP_001661921.1 TIGRFAM: PTS system, mannitol-specific IIC subunit; PFAM: phosphotransferase system, EIIC; phosphotransferase system, lactose/cellobiose-specific IIB subunit YP_001661922.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit; PRD domain protein; Helix-turn-helix, type 11 domain protein YP_001661923.1 PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 YP_001661924.1 PFAM: Mannitol dehydrogenase, C-terminal domain; Mannitol dehydrogenase rossman, N-terminal domain YP_001661925.1 PFAM: metallophosphoesterase; 5'-Nucleotidase domain protein; SH3, type 3 domain protein; SMART: SH3 domain protein domain protein YP_001661926.1 TIGRFAM: putative TIM-barrel protein, nifR3 family; PFAM: dihydrouridine synthase, DuS; dihydroorotate dehydrogenase YP_001661927.1 PFAM: protein of unknown function DUF81 YP_001661929.1 PFAM: ABC-3 protein YP_001661930.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661931.1 PFAM: periplasmic solute binding protein YP_001661932.1 PFAM: ferric-uptake regulator YP_001661933.1 PFAM: ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001661934.1 PFAM: protein of unknown function DUF58 YP_001661936.1 PFAM: LemA family protein YP_001661937.1 PFAM: regulatory protein, LysR; LysR, substrate-binding YP_001661938.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001661939.1 with AsrAC catalyzes the reduction of sulfite to hydrogen sulfide YP_001661940.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; nitrite/sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein; nitrite and sulphite reductase 4Fe-4S region YP_001661941.1 TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase, class V YP_001661942.1 TIGRFAM: SUF system FeS assembly protein, NifU family; PFAM: nitrogen-fixing NifU domain protein YP_001661943.1 PFAM: protein of unknown function DUF477 YP_001661944.1 PFAM: protein of unknown function DUF820 YP_001661945.1 PFAM: putative RNA methylase YP_001661948.1 PFAM: periplasmic binding protein YP_001661949.1 PFAM: transport system permease protein YP_001661950.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661951.1 responsible for the amidation of carboxylic groups at position A and C of cobyrinic acid or hydrogenobrynic acid YP_001661952.1 catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation YP_001661953.1 TIGRFAM: cobalamin biosynthesis protein CobD; PFAM: cobalamin biosynthesis protein CbiB YP_001661956.1 TIGRFAM: putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase, class I and II YP_001661957.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_001661958.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_001661959.1 PFAM: cobalamin (vitamin B12) biosynthesis CbiX protein YP_001661960.1 PFAM: Precorrin-8X methylmutase CbiC/CobH YP_001661961.1 Catalyzes the methylation of C-1 in cobalt-precorrin-5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A YP_001661962.1 TIGRFAM: precorrin-6y C5,15-methyltransferase (decarboxylating), CbiE subunit; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001661963.1 TIGRFAM: precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit YP_001661964.1 TIGRFAM: precorrin-2 C20-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001661965.1 TIGRFAM: precorrin-4 C11-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001661966.1 catalyzes the formation of cobalt-precorrin 4 from cobalt-precorrin 3 YP_001661967.1 TIGRFAM: precorrin-3B C17-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase YP_001661968.1 TIGRFAM: precorrin-6x reductase; PFAM: Precorrin-6x reductase CbiJ/CobK YP_001661969.1 PFAM: glutamyl-tRNA reductase; Shikimate/quinate 5-dehydrogenase YP_001661970.1 TIGRFAM: porphobilinogen deaminase; PFAM: Porphobilinogen deaminase YP_001661971.1 TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Uroporphyrinogen III synthase HEM4 YP_001661972.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_001661973.1 TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; siroheme synthase; PFAM: aminotransferase class-III YP_001661975.1 catalyzes the ATP-dependent transport of cobalt YP_001661976.1 TIGRFAM: cobalt transport protein; PFAM: Cobalt transport protein CbiN YP_001661977.1 TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: cobalt transport protein YP_001661978.1 TIGRFAM: cobalt ABC transporter, ATPase subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001661979.1 Converts isocitrate to alpha ketoglutarate YP_001661981.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661982.1 PFAM: ABC-2 type transporter YP_001661983.1 PFAM: Rhomboid family protein YP_001661985.1 PFAM: protein of unknown function DUF1648 YP_001661987.1 PFAM: GCN5-related N-acetyltransferase YP_001661992.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001661993.1 PFAM: ABC-2 type transporter YP_001661994.1 PFAM: GCN5-related N-acetyltransferase YP_001661998.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662000.1 PFAM: regulatory protein, LuxR; Bacterio-opsin activator, HTH domain protein YP_001662001.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001662002.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662004.1 PFAM: Abortive infection protein YP_001662007.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001662008.1 PFAM: transposase, mutator type YP_001662011.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662012.1 PFAM: ABC-2 type transporter YP_001662016.1 PFAM: Auxin Efflux Carrier YP_001662020.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662022.1 PFAM: regulatory protein GntR, HTH; Helix-turn-helix, type 11 domain protein YP_001662024.1 PFAM: peptidase M42 family protein YP_001662025.1 PFAM: peptidase M42 family protein YP_001662026.1 PFAM: peptidase M18, aminopeptidase I; peptidase M20; peptidase M42 family protein YP_001662027.1 PFAM: Rubrerythrin; protein of unknown function DUF125, transmembrane YP_001662029.1 PFAM: Integrase, catalytic region YP_001662030.1 SMART: AAA ATPase YP_001662031.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase) YP_001662032.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein YP_001662033.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001662037.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer; Cache, type 2 domain protein YP_001662038.1 TIGRFAM: glutamate formiminotransferase; PFAM: Formiminotransferase domain protein; Formiminotransferase-like YP_001662041.1 PFAM: protein of unknown function DUF86 YP_001662042.1 PFAM: glycoside hydrolase, family 4 YP_001662043.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662044.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662045.1 PFAM: extracellular solute-binding protein, family 1 YP_001662046.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase internal region YP_001662047.1 PFAM: helix-turn-helix- domain containing protein, AraC type; response regulator receiver YP_001662048.1 PFAM: Formiminotransferase-cyclodeaminase YP_001662049.1 PFAM: basic membrane lipoprotein YP_001662050.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662051.1 PFAM: inner-membrane translocator YP_001662052.1 PFAM: inner-membrane translocator YP_001662053.1 TIGRFAM: cytidine deaminase; PFAM: CMP/dCMP deaminase, zinc-binding YP_001662054.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_001662055.1 TIGRFAM: pyrimidine-nucleoside phosphorylase; PFAM: glycosyl transferase, family 3; Pyrimidine nucleoside phosphorylase, C-terminal domain YP_001662056.1 PFAM: chemotaxis sensory transducer YP_001662058.1 TIGRFAM: PTS system, N-acetylglucosamine-specific IIBC subunit; PTS system, glucose-like IIB subunint; PFAM: phosphotransferase system PTS, EIIB protein; phosphotransferase system, EIIC YP_001662059.1 TIGRFAM: PTS system, glucose subfamily, IIA subunit; PFAM: sugar-specific permease, EIIA 1 domain YP_001662060.1 PFAM: CAT RNA-binding domain protein; PRD domain protein YP_001662061.1 in Methanococcus jannaschii this protein catalyzes the condensation of alpha-ketoglutarate and acetyl-CoA to form trans-homoaconitate; functions in alphaketosuberate synthesis which is a precursor in coenzyme B and biotin synthesis YP_001662062.1 Catalyzes the conversion of citrate to isocitrate YP_001662065.1 PFAM: C4-dicarboxylate anaerobic carrier; Citrate transporter; TRAP C4-dicarboxylate transport system permease DctM subunit YP_001662068.1 PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein YP_001662070.1 PFAM: glucose-inhibited division protein A YP_001662071.1 TIGRFAM: aspartate 1-decarboxylase; PFAM: aspartate decarboxylase YP_001662072.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_001662073.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_001662074.1 PFAM: oxidoreductase domain protein YP_001662076.1 PFAM: phage integrase family protein YP_001662078.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_001662079.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_001662080.1 PFAM: major facilitator superfamily MFS_1 YP_001662082.1 PFAM: protein of unknown function DUF421 YP_001662083.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001662084.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001662085.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001662086.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001662088.1 PFAM: protein of unknown function DUF1256 YP_001662090.1 PFAM: Rubrerythrin; Rubredoxin-type Fe(Cys)4 protein YP_001662091.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001662092.1 TIGRFAM: helicase, RecD/TraA family; SMART: Helix-hairpin-helix DNA-binding, class 1; AAA ATPase YP_001662093.1 PFAM: phosphoribosyltransferase YP_001662097.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_001662098.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook YP_001662100.1 binds to flagellin and appears to stabilize flagellin during flagella assembly YP_001662101.1 PFAM: carbon storage regulator YP_001662102.1 PFAM: flagellin domain protein YP_001662103.1 PFAM: LAGLIDADG DNA endonuclease YP_001662104.1 TIGRFAM: DNA adenine methylase; PFAM: D12 class N6 adenine-specific DNA methyltransferase YP_001662105.1 PFAM: DpmII restriction endonuclease YP_001662106.1 PFAM: putative RNA methylase YP_001662107.1 TIGRFAM: asparagine synthase (glutamine-hydrolyzing); PFAM: glutamine amidotransferase, class-II; asparagine synthase YP_001662109.1 PFAM: flagellar protein FlaG protein YP_001662110.1 PFAM: flagellar hook-associated protein 2 domain protein; flagellar hook-associated 2 domain protein; flagellin hook IN repeat protein YP_001662111.1 PFAM: flagellar protein FliS YP_001662114.1 PFAM: extracellular solute-binding protein, family 3; SMART: ionotropic glutamate receptor YP_001662115.1 TIGRFAM: polar amino acid ABC transporter, inner membrane subunit; PFAM: binding-protein-dependent transport systems inner membrane component YP_001662116.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662117.1 TIGRFAM: ribosomal subunit interface protein; PFAM: sigma 54 modulation protein/ribosomal protein S30EA YP_001662119.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001662121.1 PFAM: 3H domain protein; Helix-turn-helix, type 11 domain protein YP_001662123.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_001662124.1 TIGRFAM: peptide chain release factor 2; PFAM: Class I peptide chain release factor; PCRF domain protein YP_001662125.1 PFAM: RNA binding S1 domain protein; SMART: Resolvase, RNase H domain protein fold YP_001662126.1 PFAM: copper amine oxidase domain protein YP_001662128.1 PFAM: amidohydrolase; Amidohydrolase 3 YP_001662129.1 PFAM: amidinotransferase YP_001662130.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_001662131.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_001662133.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001662134.1 PFAM: protein of unknown function UPF0079 YP_001662135.1 PFAM: peptidase M22, glycoprotease YP_001662136.1 TIGRFAM: ribosomal-protein-alanine acetyltransferase; PFAM: GCN5-related N-acetyltransferase YP_001662137.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_001662138.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001662139.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662140.1 PFAM: MotA/TolQ/ExbB proton channel YP_001662141.1 PFAM: OmpA/MotB domain protein YP_001662142.1 modulates transcription in response to the NADH/NAD(+) redox state YP_001662144.1 PFAM: response regulator receiver; LytTr DNA-binding region YP_001662145.1 PFAM: ATP-binding region, ATPase domain protein domain protein YP_001662146.1 PFAM: Accessory gene regulator B YP_001662148.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein YP_001662149.1 PFAM: ferredoxin-dependent glutamate synthase YP_001662150.1 PFAM: HhH-GPD family protein; 8-oxoguanine DNA glycosylase domain protein YP_001662151.1 PFAM: protein of unknown function DUF554 YP_001662153.1 PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin YP_001662156.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_001662157.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_001662158.1 TIGRFAM: inosine-5'-monophosphate dehydrogenase; PFAM: CBS domain containing protein; IMP dehydrogenase/GMP reductase YP_001662159.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_001662160.1 PFAM: Xanthine/uracil/vitamin C permease YP_001662161.1 TIGRFAM: phosphoribosylaminoimidazole carboxylase, catalytic subunit; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase YP_001662162.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_001662163.1 TIGRFAM: phosphoribosylformylglycinamidine synthase, purS; PFAM: phosphoribosylformylglycinamidine synthetase PurS YP_001662164.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001662165.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_001662166.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_001662167.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_001662168.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_001662169.1 involved in de novo purine biosynthesis YP_001662170.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_001662171.1 TIGRFAM: glutamate racemase; PFAM: Asp/Glu racemase YP_001662172.1 TIGRFAM: amidohydrolase; PFAM: peptidase M20; peptidase dimerisation domain protein YP_001662173.1 PFAM: multi antimicrobial extrusion protein MatE; polysaccharide biosynthesis protein; virulence factor MVIN family protein YP_001662174.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and IscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; in Thermotoga this enzyme has an extra C-terminal domain YP_001662175.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit; PRD domain protein; Helix-turn-helix, type 11 domain protein YP_001662177.1 PFAM: phosphotransferase system, lactose/cellobiose-specific IIB subunit YP_001662178.1 TIGRFAM: PTS system, lactose/cellobiose family IIC subunit; PFAM: phosphotransferase system, EIIC YP_001662179.1 PFAM: phosphotransferase system PTS, lactose/cellobiose-specific IIA subunit YP_001662180.1 TIGRFAM: TrpR like protein, YerC/YecD; PFAM: Trp repressor YP_001662181.1 TIGRFAM: ATP-dependent DNA helicase PcrA; PFAM: UvrD/REP helicase YP_001662182.1 TIGRFAM: DNA ligase, NAD-dependent; PFAM: helix-hairpin-helix motif; BRCT domain protein; zinc-finger, NAD-dependent DNA ligase C4-type; NAD-dependent DNA ligase, OB-fold; NAD-dependent DNA ligase, adenylation; SMART: Helix-hairpin-helix DNA-binding, class 1; NAD-dependent DNA ligase-like YP_001662183.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_001662184.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001662185.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_001662188.1 PFAM: Integrase, catalytic region YP_001662189.1 SMART: AAA ATPase YP_001662190.1 PFAM: extracellular solute-binding protein, family 5 YP_001662191.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662192.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662193.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001662194.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001662195.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_001662196.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_001662197.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase YP_001662198.1 PFAM: glutamine synthetase, catalytic region YP_001662199.1 TIGRFAM: ammonium transporter; PFAM: Rh family protein/ammonium transporter YP_001662200.1 PFAM: nitrogen regulatory protein P-II YP_001662201.1 PFAM: glutamine amidotransferase class-I YP_001662202.1 PFAM: glutamine amidotransferase, class-II YP_001662203.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; ferredoxin-dependent glutamate synthase YP_001662204.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001662205.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001662206.1 PFAM: glutamate synthase, alpha subunit domain protein YP_001662207.1 catalyzes the formation of biotin from dethiobiotin and sulfur YP_001662208.1 PFAM: iron-containing alcohol dehydrogenase YP_001662209.1 TIGRFAM: phosphomethylpyrimidine kinase; PFAM: Phosphomethylpyrimidine kinase type-1 YP_001662210.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_001662211.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_001662212.1 TIGRFAM: thiW protein YP_001662213.1 TIGRFAM: putative hydroxymethylpyrimidine transporter CytX; PFAM: permease for cytosine/purines, uracil, thiamine, allantoin YP_001662215.1 TIGRFAM: phosphate transport system regulatory protein PhoU; PFAM: PhoU family protein YP_001662216.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662218.1 PFAM: Integrase, catalytic region YP_001662219.1 PFAM: regulatory protein, DeoR; regulatory protein, ArsR; Helix-turn-helix, type 11 domain protein YP_001662220.1 PFAM: PfkB domain protein YP_001662221.1 TIGRFAM: PTS system, fructose subfamily, IIA subunit; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 YP_001662222.1 TIGRFAM: PTS system, fructose-specific, IIB subunnit; PTS system, fructose subfamily, IIC subunit; PFAM: phosphotransferase system, EIIC; phosphotransferase system PTS, fructose-specific IIB subunit YP_001662224.1 PFAM: heat shock protein Hsp20 YP_001662225.1 PFAM: Abortive infection protein YP_001662226.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001662227.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_001662228.1 TIGRFAM: pur operon repressor; PFAM: phosphoribosyltransferase; Pur operon repressor YP_001662229.1 stage V sporulation protein G; essential for spore formation and a negative regulator of asymmetric septation in Bacillus; involved in methicillin-resistance, biofilm formation and capsular polysaccharide synthesis in Staphylococcus YP_001662230.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_001662231.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_001662232.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001662233.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001662234.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein YP_001662235.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_001662237.1 TIGRFAM: transcription-repair coupling factor; PFAM: helicase domain protein; transcription factor CarD; TRCF domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001662238.1 PFAM: PpiC-type peptidyl-prolyl cis-trans isomerase YP_001662239.1 TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT/AbrB domain protein YP_001662240.1 PFAM: peptidase U57, YabG YP_001662241.1 PFAM: protein of unknown function DUF1021 YP_001662242.1 PFAM: Peptidoglycan-binding LysM YP_001662243.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_001662244.1 PFAM: regulatory protein GntR, HTH; GntR domain protein YP_001662247.1 PFAM: GerA spore germination protein YP_001662248.1 TIGRFAM: spore germination protein; PFAM: Spore germination protein YP_001662249.1 PFAM: spore germination B3 GerAC family protein YP_001662251.1 PFAM: Peptidoglycan-binding domain 1 protein; cell wall hydrolase, SleB YP_001662252.1 PFAM: Propeptide, PepSY amd peptidase M4 YP_001662254.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_001662256.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_001662258.1 TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I YP_001662259.1 TIGRFAM: para-aminobenzoate synthase, subunit I; PFAM: Anthranilate synthase component I and chorismate binding protein; Anthranilate synthase component I domain protein YP_001662260.1 PFAM: aminotransferase, class IV YP_001662261.1 PFAM: FMN-binding domain protein YP_001662262.1 PFAM: major facilitator superfamily MFS_1 YP_001662263.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001662264.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001662265.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662266.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662267.1 PFAM: extracellular solute-binding protein, family 5 YP_001662269.1 PFAM: aldo/keto reductase; 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001662270.1 PFAM: NLP/P60 protein YP_001662271.1 PFAM: iron-containing alcohol dehydrogenase; aldehyde dehydrogenase; 3-dehydroquinate synthase YP_001662272.1 TIGRFAM: methylated-DNA--protein-cysteine methyltransferase; PFAM: methylated-DNA-[protein]-cysteine S-methyltransferase YP_001662274.1 PFAM: regulatory protein, MarR; regulatory protein, ArsR; transcriptional regulator TrmB; Penicillinase repressor YP_001662275.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001662276.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001662277.1 TIGRFAM: putative proton-coupled thiamine transporter YuaJ YP_001662278.1 PFAM: phosphoesterase, PA-phosphatase related YP_001662279.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; magnesium-translocating P-type ATPase; PFAM: cation transporting ATPase domain protein domain protein; Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein YP_001662280.1 PFAM: regulatory protein, LuxR; GAF domain protein YP_001662287.1 PFAM: protein of unknown function DUF218 YP_001662288.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription YP_001662292.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662294.1 PFAM: PHP C-terminal domain protein; SMART: DNA polymerase X; phosphoesterase PHP domain protein; Helix-hairpin-helix DNA-binding, class 1 YP_001662295.1 TIGRFAM: glutamate synthase (NADPH), homotetrameric; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001662296.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein YP_001662297.1 PFAM: Alcohol dehydrogenase, zinc-binding domain protein; Alcohol dehydrogenase GroES domain protein YP_001662298.1 PFAM: iron-containing alcohol dehydrogenase YP_001662299.1 TIGRFAM: PAS sensor protein; PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; hydrogenase large subunit domain protein; Fe-S cluster domain protein; PAS fold domain protein; SMART: PAS domain containing protein YP_001662300.1 PFAM: Stage II sporulation E family protein YP_001662301.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_001662302.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_001662303.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_001662304.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_001662305.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_001662306.1 TIGRFAM: carbamoyl-phosphate synthase, large subunit; PFAM: phosphoribosylglycinamide synthetase; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain, oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; MGS domain protein YP_001662307.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_001662308.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_001662309.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; calcium-translocating P-type ATPase, PMCA-type; PFAM: cation transporting ATPase domain protein domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; E1-E2 ATPase-associated domain protein YP_001662311.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_001662312.1 PFAM: Ferritin, Dps family protein YP_001662313.1 PFAM: protein of unknown function DUF1312 YP_001662314.1 PFAM: Heptaprenyl diphosphate synthase component I YP_001662315.1 PFAM: Polyprenyl synthetase YP_001662316.1 PFAM: ApbE family lipoprotein YP_001662317.1 TIGRFAM: 1,4-dihydroxy-2-naphthoate octaprenyltransferase; PFAM: UbiA prenyltransferase YP_001662318.1 PFAM: FMN-binding domain protein YP_001662320.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001662321.1 PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase YP_001662322.1 PFAM: major facilitator superfamily MFS_1 YP_001662323.1 TIGRFAM: desulfoferrodoxin; PFAM: Desulfoferrodoxin, ferrous iron-binding region; Desulfoferrodoxin Dfx domain protein YP_001662325.1 catalyzes the formation of fumarate from aspartate YP_001662326.1 TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Miro domain protein; SMART: Ras small GTPase, Ras type YP_001662327.1 PFAM: protein of unknown function DUF894, DitE; major facilitator superfamily MFS_1 YP_001662328.1 PFAM: TPR repeat-containing protein; Tetratricopeptide TPR_2 repeat protein; SMART: helix-turn-helix domain protein; Tetratricopeptide domain protein YP_001662329.1 TIGRFAM: MazG family protein; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; MazG nucleotide pyrophosphohydrolase YP_001662330.1 PFAM: histone family protein DNA-binding protein YP_001662331.1 PFAM: RNA-binding S4 domain protein YP_001662332.1 TIGRFAM: SpoIID/LytB domain; PFAM: Stage II sporulation D domain protein YP_001662333.1 PFAM: YabP family protein YP_001662335.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IB (PSPase-like); 2,3-diketo-5-methylthio-1-phosphopentane phosphatase; PFAM: HAD-superfamily hydrolase, subfamily IB hypothetical 1 YP_001662336.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_001662338.1 PFAM: Septum formation initiator YP_001662339.1 PFAM: RNA binding S1 domain protein YP_001662340.1 PFAM: Ppx/GppA phosphatase YP_001662341.1 PFAM: Resolvase, N-terminal domain; Recombinase YP_001662343.1 TIGRFAM: DNA binding domain, excisionase family; PFAM: regulatory protein, MerR YP_001662345.1 PFAM: helix-turn-helix domain protein YP_001662346.1 PFAM: helix-turn-helix domain protein YP_001662360.1 PFAM: peptidase M23B; Lytic transglycosylase, catalytic YP_001662363.1 PFAM: SAF domain YP_001662365.1 PFAM: type II secretion system protein E YP_001662366.1 PFAM: type II secretion system protein YP_001662373.1 PFAM: Peptidoglycan-binding domain 1 protein YP_001662374.1 PFAM: peptidase A24A, prepilin type IV YP_001662375.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001662378.1 PFAM: Radical SAM domain protein YP_001662387.1 PFAM: protein of unknown function DUF1648 YP_001662389.1 PFAM: dehydrogenase, E1 component YP_001662390.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001662391.1 PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; GAF domain protein; ATPase associated with various cellular activities, AAA_5; SMART: PAS domain containing protein; AAA ATPase YP_001662392.1 PFAM: ROK family protein YP_001662393.1 PFAM: extracellular solute-binding protein, family 1 YP_001662394.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662395.1 PFAM: Integrase, catalytic region YP_001662396.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662398.1 PFAM: glycoside hydrolase 15-related YP_001662400.1 PFAM: transposase IS3/IS911 family protein YP_001662401.1 PFAM: Integrase, catalytic region YP_001662406.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001662407.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001662409.1 PFAM: regulatory protein, ArsR YP_001662410.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001662411.1 TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001662412.1 PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; Pyridoxal-dependent decarboxylase YP_001662413.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001662414.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; copper ion binding protein; copper-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001662415.1 PFAM: EAL domain protein YP_001662416.1 PFAM: cell wall hydrolase/autolysin YP_001662417.1 TIGRFAM: phage holin, LL-H family YP_001662419.1 TIGRFAM: 8-amino-7-oxononanoate synthase; pyridoxal phosphate-dependent acyltransferase, putative; PFAM: aminotransferase, class I and II; aminotransferase class-III YP_001662420.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_001662421.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein YP_001662423.1 PFAM: protein of unknown function DUF1284 YP_001662425.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662427.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in B. subtilis has been shown to regulate cell envelope modification and may effect antibiotic resistance YP_001662428.1 PFAM: protein of unknown function DUF6, transmembrane YP_001662429.1 PFAM: Stage II sporulation E family protein; SMART: protein phosphatase 2C domain protein YP_001662430.1 TIGRFAM: tRNA(Ile)-lysidine synthetase; PFAM: PP-loop domain protein YP_001662431.1 TIGRFAM: hypoxanthine phosphoribosyltransferase; PFAM: phosphoribosyltransferase YP_001662432.1 TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase, central domain protein; peptidase M41, FtsH extracellular; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001662433.1 TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase A domain protein domain protein; SMART: PAS domain containing protein YP_001662434.1 PFAM: formate-tetrahydrofolate ligase, FTHFS YP_001662436.1 PFAM: carboxyl transferase YP_001662438.1 PFAM: biotin/lipoyl attachment domain-containing protein YP_001662440.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_001662441.1 TIGRFAM: spore germination protein; PFAM: Spore germination protein YP_001662442.1 PFAM: GerA spore germination protein YP_001662443.1 PFAM: spore germination B3 GerAC family protein YP_001662447.1 PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase; Shikimate/quinate 5-dehydrogenase YP_001662448.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_001662449.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_001662450.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_001662451.1 TIGRFAM: dihydropteroate synthase; PFAM: dihydropteroate synthase, DHPS YP_001662452.1 TIGRFAM: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; PFAM: 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK YP_001662453.1 PFAM: 6-pyruvoyl tetrahydropterin synthase and hypothetical protein YP_001662454.1 Regulatory factor involved in maltose metabolism YP_001662455.1 PFAM: peptidase S9, prolyl oligopeptidase active site domain protein; Acetyl xylan esterase YP_001662456.1 PFAM: protein of unknown function DUF1614 YP_001662457.1 PFAM: protein of unknown function DUF896 YP_001662458.1 PFAM: aminotransferase class-III YP_001662460.1 Catalyzes the rate-limiting step in dNTP synthesis YP_001662461.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; GAF domain protein YP_001662462.1 PFAM: regulatory protein, DeoR; phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; M trans-acting positive regulator; PRD domain protein; Helix-turn-helix, type 11 domain protein YP_001662463.1 TIGRFAM: PTS system, fructose subfamily, IIA subunit; PFAM: phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 YP_001662464.1 TIGRFAM: PTS system, fructose subfamily, IIC subunit; PFAM: phosphotransferase system, EIIC YP_001662465.1 TIGRFAM: PTS system, fructose-specific, IIB subunnit; PFAM: phosphotransferase system PTS, fructose-specific IIB subunit YP_001662466.1 TIGRFAM: phosphoenolpyruvate-protein phosphotransferase; PFAM: PEP-utilizing enzyme; PEP-utilising enzyme, mobile region; PEP-utilising enzyme domain protein YP_001662467.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001662468.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001662469.1 PFAM: malic enzyme domain protein; malic enzyme, NAD-binding YP_001662471.1 PFAM: Firmicute transcriptional repressor of class III stress genes YP_001662472.1 PFAM: UvrB/UvrC protein YP_001662473.1 PFAM: ATP:guanido phosphotransferase YP_001662474.1 PFAM: UvrB/UvrC protein; AAA ATPase, central domain protein; Clp N terminal domain protein; ATPase associated with various cellular activities, AAA_5; ATPase AAA-2 domain protein; SMART: AAA ATPase YP_001662475.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_001662477.1 PFAM: PilT protein domain protein; deoxyribonuclease/rho motif-related TRAM; SMART: Nucleotide binding protein, PINc YP_001662478.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_001662479.1 PFAM: PGAP1 family protein YP_001662480.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_001662481.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_001662483.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001662484.1 TIGRFAM: serine O-acetyltransferase YP_001662485.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_001662487.1 TIGRFAM: RNA methyltransferase, TrmH family, group 3; PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding YP_001662488.1 PFAM: protein of unknown function DUF901 YP_001662489.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates YP_001662490.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001662491.1 TIGRFAM: preprotein translocase, SecE subunit; PFAM: protein secE/sec61-gamma protein YP_001662492.1 Modulates Rho-dependent transcription termination YP_001662493.1 binds directly to 23S ribosomal RNA YP_001662494.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_001662495.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_001662496.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_001662497.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_001662498.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_001662499.1 in Bacillus subtilis this non-essential protein associates with the ribosome YP_001662500.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_001662501.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_001662502.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_001662503.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_001662504.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_001662505.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_001662506.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_001662507.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_001662508.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_001662509.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_001662510.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_001662511.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_001662512.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_001662513.1 one of the stabilizing components for the large ribosomal subunit YP_001662514.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_001662515.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_001662516.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_001662517.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_001662518.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_001662519.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_001662520.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_001662521.1 binds 5S rRNA along with protein L5 and L25 YP_001662522.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_001662523.1 late assembly protein YP_001662524.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_001662525.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_001662526.1 TIGRFAM: methionine aminopeptidase, type I; PFAM: peptidase M24 YP_001662528.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_001662529.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_001662530.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_001662531.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_001662532.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_001662533.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_001662534.1 is a component of the macrolide binding site in the peptidyl transferase center YP_001662535.1 with CbiNQ forms the ABC transporter for cobalt import; Mycoplasmas have two adjacent copies of this gene YP_001662536.1 with CbiNQ forms the ABC transporter for cobalt import; Clostridia have two adjacent copies of this gene YP_001662537.1 PFAM: cobalt transport protein YP_001662538.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_001662539.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_001662540.1 forms a direct contact with the tRNA during translation YP_001662543.1 PFAM: Rubrerythrin; Ferritin, Dps family protein YP_001662544.1 PFAM: Desulfoferrodoxin, ferrous iron-binding region YP_001662546.1 PFAM: carbon starvation protein CstA YP_001662547.1 TIGRFAM: amino acid carrier protein; PFAM: sodium:alanine symporter YP_001662548.1 PFAM: cation antiporter YP_001662549.1 PFAM: multiple resistance and pH regulation protein F YP_001662550.1 TIGRFAM: monovalent cation/proton antiporter, MnhG/PhaG subunit; PFAM: Na+/H+ antiporter subunit YP_001662552.1 PFAM: Na+/H+ antiporter MnhB subunit-related protein YP_001662553.1 PFAM: NADH-ubiquinone oxidoreductase, chain 4L YP_001662554.1 PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001662555.1 PFAM: NADH/Ubiquinone/plastoquinone (complex I) YP_001662557.1 PFAM: thymidylate synthase complementing protein ThyX YP_001662558.1 PFAM: MazG nucleotide pyrophosphohydrolase YP_001662560.1 PFAM: Coat F domain protein YP_001662561.1 TIGRFAM: thioredoxin reductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; HI0933 family protein; FAD dependent oxidoreductase YP_001662562.1 PFAM: Peptidoglycan-binding domain 1 protein; Peptidoglycan-binding LysM YP_001662563.1 PFAM: cell wall hydrolase/autolysin YP_001662564.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001662565.1 PFAM: ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5 YP_001662566.1 PFAM: protein of unknown function DUF58 YP_001662567.1 PFAM: transglutaminase domain protein YP_001662569.1 PFAM: transport-associated YP_001662570.1 PFAM: transposase IS116/IS110/IS902 family protein YP_001662571.1 PFAM: protein of unknown function DUF147 YP_001662572.1 PFAM: YbbR family protein YP_001662573.1 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate YP_001662574.1 catalyzes the synthesis of butanoylphosphate from butanoyl-CoA and inorganic phosphate YP_001662575.1 PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region YP_001662576.1 catalyzes the phosphorylation of 2-butanoate to butanoyl phosphate YP_001662578.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001662579.1 catalyzes the coenzyme A-dependent oxidation of 3-methyl-2-oxobutanoate coupled to the reduction of ferredoxin producing S-(2-methylpropanoyl)-CoA YP_001662580.1 PFAM: thiamine pyrophosphate enzyme domain protein TPP-binding YP_001662581.1 TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase YP_001662582.1 PFAM: phosphate acetyl/butaryl transferase YP_001662583.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; thiamine pyrophosphate enzyme domain protein TPP-binding YP_001662584.1 Involved in the incorporation of exogenous aryl acids in the biosynthesis of aromatic amino acids: catalysis of the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. YP_001662585.1 PFAM: phospholipid/glycerol acyltransferase YP_001662586.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_001662587.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_001662588.1 PFAM: protein of unknown function UPF0047 YP_001662589.1 PFAM: ATP dependent DNA ligase YP_001662590.1 PFAM: Ku domain protein YP_001662591.1 PFAM: Peptidoglycan-binding domain 1 protein; Peptidoglycan-binding LysM YP_001662593.1 PFAM: protein of unknown function DUF503 YP_001662594.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_001662595.1 PFAM: helix-turn-helix domain protein YP_001662598.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_001662599.1 TIGRFAM: carbohydrate kinase, YjeF related protein; PFAM: protein of unknown function UPF0031; YjeF-family N-terminal domain protein YP_001662601.1 TIGRFAM: alanine racemase; PFAM: alanine racemase domain protein YP_001662602.1 PFAM: CopG domain protein DNA-binding domain protein YP_001662603.1 PFAM: PemK family protein YP_001662604.1 PFAM: protein of unknown function DUF161 YP_001662605.1 PFAM: Transketolase domain protein YP_001662606.1 PFAM: Transketolase, central region; Transketolase domain protein YP_001662608.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001662609.1 PFAM: Na+/H+ antiporter NhaC YP_001662610.1 PFAM: Rubredoxin-type Fe(Cys)4 protein YP_001662611.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_001662612.1 PFAM: homoserine dehydrogenase; homoserine dehydrogenase, NAD-binding YP_001662613.1 TIGRFAM: O-acetylhomoserine/O-acetylserine sulfhydrylase; PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; DegT/DnrJ/EryC1/StrS aminotransferase YP_001662614.1 TIGRFAM: homoserine O-acetyltransferase; PFAM: alpha/beta hydrolase fold YP_001662615.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001662616.1 TIGRFAM: putative RNA methylase, NOL1/NOP2/sun family; PFAM: Fmu (Sun) domain protein YP_001662617.1 PFAM: putative carbohydrate binding; glycosyltransferase 36; glycosyltransferase 36 associated YP_001662618.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662619.1 PFAM: ABC-2 type transporter YP_001662622.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001662623.1 PFAM: Xylose isomerase domain protein TIM barrel YP_001662625.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001662626.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662627.1 PFAM: inner-membrane translocator YP_001662628.1 PFAM: Xylose isomerase domain protein TIM barrel YP_001662629.1 TIGRFAM: putative glucokinase, ROK family; PFAM: ROK family protein YP_001662630.1 PFAM: Semialdehyde dehydrogenase, NAD - binding; oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001662631.1 PFAM: HEPN domain protein YP_001662632.1 PFAM: DNA polymerase, beta domain protein region YP_001662633.1 PFAM: protein of unknown function DUF820 YP_001662634.1 PFAM: tRNA synthetase, class II (G, H, P and S) YP_001662635.1 short form of enzyme; requires HisZ for function; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms heteromultimer of HisG and HisZ YP_001662636.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_001662637.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_001662638.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_001662639.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_001662640.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_001662641.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_001662642.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_001662643.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_001662644.1 PFAM: peptidase M19, renal dipeptidase YP_001662645.1 PFAM: LmbE family protein YP_001662646.1 TIGRFAM: spore germination protein; PFAM: Spore germination protein YP_001662647.1 PFAM: Na+/Pi-cotransporter YP_001662648.1 PFAM: transferase hexapeptide repeat containing protein; Nucleotidyl transferase; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I YP_001662650.1 TIGRFAM: CRISPR-associated protein Cas4 YP_001662651.1 PFAM: polysaccharide deacetylase YP_001662653.1 PFAM: glycerol-3-phosphate responsive antiterminator YP_001662654.1 TIGRFAM: MIP family channel protein; PFAM: major intrinsic protein YP_001662655.1 TIGRFAM: glycerol kinase; PFAM: carbohydrate kinase, FGGY YP_001662656.1 PFAM: Rab GTPase activator; FAD dependent oxidoreductase; BFD domain protein [2Fe-2S]-binding domain protein YP_001662657.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein YP_001662658.1 PFAM: protein of unknown function DUF1667 YP_001662659.1 TIGRFAM: PAS sensor protein; PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; ATPase associated with various cellular activities, AAA_5; PAS fold domain protein; SMART: PAS domain containing protein; AAA ATPase YP_001662660.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_001662661.1 TIGRFAM: dihydroxyacetone kinase, L subunit; PFAM: Dak phosphatase YP_001662662.1 TIGRFAM: dihydroxyacetone kinase, phosphotransfer subunit; PFAM: PTS system fructose subfamily IIA component YP_001662663.1 PFAM: beta-lactamase domain protein YP_001662664.1 PFAM: Heat shock protein 70 YP_001662668.1 TIGRFAM: integral membrane protein TIGR01906; PFAM: Integral membrane protein 1906 YP_001662669.1 TIGRFAM: ATP-dependent metalloprotease FtsH; PFAM: peptidase M41; AAA ATPase, central domain protein; SMART: AAA ATPase YP_001662670.1 TIGRFAM: putative CoA-substrate-specific enzyme activase; PFAM: ATPase, BadF/BadG/BcrA/BcrD type YP_001662671.1 PFAM: cell division protein FtsA YP_001662673.1 PFAM: DNA polymerase, beta domain protein region YP_001662674.1 TIGRFAM: nucleotidyltransferase substrate binding protein, HI0074 family; PFAM: Nucleotidyltransferase substrate binding protein, HI0074 YP_001662675.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001662676.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_001662677.1 TIGRFAM: diaminopimelate decarboxylase; PFAM: Orn/DAP/Arg decarboxylase 2 YP_001662679.1 PFAM: ABC transporter related; TOBE domain protein; Transport-associated OB domain protein; SMART: AAA ATPase YP_001662681.1 TIGRFAM: cell division ATP-binding protein FtsE; PFAM: ABC transporter related; SMART: AAA ATPase YP_001662682.1 PFAM: protein of unknown function DUF214 YP_001662683.1 PFAM: peptidase M23B YP_001662684.1 TIGRFAM: carboxyl-terminal protease; PFAM: PDZ/DHR/GLGF domain protein; peptidase S41 YP_001662685.1 PFAM: PDZ/DHR/GLGF domain protein YP_001662686.1 catalyzes the formation of (2R)-3-sulfolactate from (2R)-2-phospho-3-sulfolactate YP_001662687.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_001662688.1 TIGRFAM: excinuclease ABC, A subunit; PFAM: ABC transporter related; SMART: AAA ATPase YP_001662689.1 PFAM: Forkhead-associated protein YP_001662690.1 PFAM: cell cycle protein YP_001662691.1 PFAM: penicillin-binding protein, transpeptidase YP_001662692.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_001662693.1 TIGRFAM: biotin--acetyl-CoA-carboxylase ligase; PFAM: biotin protein ligase domain protein; biotin/lipoate A/B protein ligase; Helix-turn-helix, type 11 domain protein YP_001662694.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_001662695.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001662696.1 TIGRFAM: putative glucokinase, ROK family; PFAM: ROK family protein; ATPase, BadF/BadG/BcrA/BcrD type YP_001662697.1 PFAM: AMP-dependent synthetase and ligase YP_001662698.1 PFAM: protein of unknown function DUF624 YP_001662700.1 PFAM: AMMECR1 domain protein; Extradiol ring-cleavage dioxygenase, class III enzyme, subunit B YP_001662701.1 PFAM: Radical SAM domain protein YP_001662705.1 PFAM: regulatory protein, MerR; Resolvase, N-terminal domain YP_001662706.1 TIGRFAM: transposase, putative; transposase, IS605 OrfB family YP_001662707.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001662708.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001662709.1 PFAM: oxidoreductase domain protein; Oxidoreductase, C-terminal domain YP_001662710.1 PFAM: Xylose isomerase domain protein TIM barrel YP_001662711.1 PFAM: Xylose isomerase domain protein TIM barrel YP_001662712.1 PFAM: Auxin Efflux Carrier YP_001662713.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001662714.1 PFAM: regulatory protein, DeoR; Helix-turn-helix, type 11 domain protein YP_001662715.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001662716.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_001662718.1 PFAM: carbohydrate kinase, FGGY YP_001662720.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism YP_001662721.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_001662722.1 TIGRFAM: UDP-glucose 4-epimerase; PFAM: NAD-dependent epimerase/dehydratase; 3-beta hydroxysteroid dehydrogenase/isomerase; polysaccharide biosynthesis protein CapD; dTDP-4-dehydrorhamnose reductase; Male sterility C-terminal domain YP_001662723.1 PFAM: ROK family protein YP_001662725.1 PFAM: extracellular solute-binding protein, family 1 YP_001662726.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662727.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662728.1 PFAM: glycoside hydrolase, clan GH-D YP_001662729.1 PFAM: glycoside hydrolase family 2, immunoglobulin domain protein beta-sandwich; glycoside hydrolase family 2, TIM barrel; glycoside hydrolase family 2, sugar binding YP_001662730.1 PFAM: glycoside hydrolase, family 38; glycosyl hydrolase 38 domain protein YP_001662733.1 PFAM: extracellular solute-binding protein, family 1 YP_001662734.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662735.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662737.1 PFAM: helix-turn-helix- domain containing protein, AraC type; Cupin 2, conserved barrel domain protein YP_001662738.1 PFAM: Acetamidase/Formamidase YP_001662739.1 PFAM: sodium:neurotransmitter symporter YP_001662740.1 SMART: AAA ATPase YP_001662741.1 PFAM: Integrase, catalytic region YP_001662743.1 PFAM: protein of unknown function DUF815; SMART: AAA ATPase YP_001662744.1 similar to novel fructose-6-phosphate aldolase from Escherichia coli; enzyme from Methanocaldococcus janaschii shows transaldolase activity YP_001662745.1 PFAM: extracellular solute-binding protein, family 1 YP_001662746.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain YP_001662749.1 PFAM: extracellular solute-binding protein, family 1 YP_001662750.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662751.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662752.1 TIGRFAM: sucrose-6-phosphate hydrolase; PFAM: Glycosyl hydrolase family 32, N terminal domain protein; Glycosyl hydrolase family 32, C-terminal domain protein; SMART: glycoside hydrolase, family 32 YP_001662753.1 PFAM: PfkB domain protein YP_001662754.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001662755.1 PFAM: protein of unknown function DUF43 YP_001662758.1 PFAM: Methyltransferase type 11; Methyltransferase type 12 YP_001662760.1 PFAM: Dinitrogenase iron-molybdenum cofactor biosynthesis protein YP_001662761.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Cobyrinic acid a,c-diamide synthase YP_001662762.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Cobyrinic acid a,c-diamide synthase YP_001662763.1 PFAM: beta-lactamase domain protein YP_001662764.1 catalyzes the formation of biotin from dethiobiotin and sulfur YP_001662765.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein; FAD dependent oxidoreductase YP_001662766.1 PFAM: periplasmic binding protein YP_001662767.1 PFAM: transport system permease protein YP_001662768.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662769.1 PFAM: protein of unknown function UPF0066 YP_001662771.1 PFAM: FeoA family protein YP_001662772.1 PFAM: FeoA family protein YP_001662773.1 TIGRFAM: ferrous iron transport protein B; small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related; Ferrous iron transport protein B domain protein; Ferrous iron transport B domain protein; nucleoside recognition domain protein YP_001662774.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001662775.1 PFAM: ferric-uptake regulator YP_001662776.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_001662777.1 TIGRFAM: anaerobic ribonucleoside-triphosphate reductase activating protein; PFAM: Radical SAM domain protein YP_001662778.1 TIGRFAM: PAS sensor protein; diguanylate cyclase; PFAM: GGDEF domain containing protein; metal-dependent phosphohydrolase, HD sub domain; PAS fold-3 domain protein; PAS fold-4 domain protein; PAS fold domain protein; SMART: PAS domain containing protein; PAC repeat-containing protein YP_001662779.1 PFAM: protein of unknown function DUF134 YP_001662781.1 TIGRFAM: copper ion binding protein; PFAM: Heavy metal transport/detoxification protein YP_001662782.1 TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001662787.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001662788.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001662789.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate YP_001662790.1 PFAM: PP-loop domain protein YP_001662791.1 PFAM: thiamineS protein YP_001662792.1 PFAM: regulatory protein, ArsR YP_001662793.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; E1-E2 ATPase-associated domain protein YP_001662794.1 TIGRFAM: copper ion binding protein; PFAM: Heavy metal transport/detoxification protein YP_001662795.1 PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; Pyridoxal-dependent decarboxylase YP_001662796.1 PFAM: transposase IS116/IS110/IS902 family protein YP_001662797.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001662799.1 PFAM: thioesterase superfamily protein YP_001662800.1 PFAM: isochorismatase hydrolase YP_001662802.1 TIGRFAM: 2-polyprenylphenol 6-hydroxylase; PFAM: ABC-1 domain protein YP_001662803.1 PFAM: regulatory protein, TetR YP_001662804.1 PFAM: Patatin YP_001662806.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_001662807.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001662808.1 PFAM: uncharacterised P-loop ATPase protein UPF0042 YP_001662809.1 PFAM: protein of unknown function UPF0052 and CofD YP_001662810.1 PFAM: alpha amylase, catalytic region; alpha amylase, C-terminal all-beta; SMART: alpha amylase, catalytic sub domain YP_001662811.1 PFAM: extracellular solute-binding protein, family 1 YP_001662812.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662813.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662817.1 PFAM: glycoside hydrolase, family 13 domain protein Ig domain protein region domain protein; alpha amylase, catalytic region; SMART: alpha amylase, catalytic sub domain YP_001662819.1 PFAM: protein of unknown function DUF199 YP_001662820.1 TIGRFAM: phosphocarrier, HPr family; PFAM: phosphocarrier HPr protein YP_001662821.1 PFAM: CBS domain containing protein; DRTGG domain protein YP_001662822.1 catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. YP_001662824.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_001662825.1 PFAM: pyruvate kinase; PEP-utilising enzyme, mobile region YP_001662826.1 PFAM: thioesterase superfamily protein YP_001662827.1 TIGRFAM: RNA methyltransferase, TrmA family; PFAM: deoxyribonuclease/rho motif-related TRAM; (Uracil-5)-methyltransferase YP_001662828.1 PFAM: Auxin Efflux Carrier YP_001662829.1 TIGRFAM: MATE efflux family protein; PFAM: multi antimicrobial extrusion protein MatE YP_001662830.1 PFAM: regulatory protein GntR, HTH; TrkA-C domain protein YP_001662831.1 TIGRFAM: glycine betaine/L-proline ABC transporter, ATPase subunit; PFAM: CBS domain containing protein; ABC transporter related; SMART: AAA ATPase YP_001662832.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001662833.1 PFAM: Substrate-binding region of ABC-type glycine betaine transport system YP_001662834.1 TIGRFAM: 2-isopropylmalate synthase/homocitrate synthase family protein; PFAM: pyruvate carboxyltransferase; LeuA allosteric (dimerisation) domain YP_001662836.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_001662837.1 PFAM: nitroreductase YP_001662838.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_001662839.1 TIGRFAM: alpha-glucan phosphorylase; PFAM: glycosyl transferase, family 35 YP_001662840.1 PFAM: methylenetetrahydrofolate reductase YP_001662841.1 PFAM: dihydropteroate synthase, DHPS; homocysteine S-methyltransferase; Methionine synthase, B12-binding module, cap domain protein; cobalamin B12-binding domain protein YP_001662842.1 PFAM: YbaK/prolyl-tRNA synthetase associated region YP_001662843.1 PFAM: manganese containing catalase YP_001662846.1 TIGRFAM: RNA methyltransferase, TrmA family; PFAM: deoxyribonuclease/rho motif-related TRAM; (Uracil-5)-methyltransferase YP_001662848.1 PFAM: type III restriction enzyme, res subunit; protein of unknown function DUF450; SMART: DEAD-like helicases-like YP_001662851.1 PFAM: restriction modification system DNA specificity domain YP_001662852.1 PFAM: N-6 DNA methylase YP_001662853.1 PFAM: transposase, IS111A/IS1328/IS1533 YP_001662856.1 TIGRFAM: DNA binding domain, excisionase family YP_001662860.1 PFAM: Sigma-70, region 4 type 2 YP_001662864.1 PFAM: DNA-directed DNA polymerase YP_001662865.1 PFAM: BRO domain protein domain protein YP_001662867.1 PFAM: virulence-associated E family protein YP_001662869.1 PFAM: SNF2-related protein; SMART: DEAD-like helicases-like YP_001662871.1 PFAM: HNH endonuclease; SMART: HNH nuclease YP_001662873.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_001662874.1 PFAM: DNA methylase N-4/N-6 domain protein; ParB domain protein nuclease YP_001662875.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase) YP_001662881.1 PFAM: phage Terminase YP_001662882.1 TIGRFAM: phage portal protein, HK97 family; PFAM: phage portal protein YP_001662883.1 PFAM: peptidase S14, ClpP YP_001662884.1 TIGRFAM: phage major capsid protein, HK97 family; PFAM: phage major capsid protein, HK97 YP_001662886.1 TIGRFAM: uncharacterized phage protein (possible DNA packaging) YP_001662887.1 TIGRFAM: phage head-tail adaptor, putative YP_001662888.1 TIGRFAM: phage protein, HK97 gp10 family YP_001662890.1 TIGRFAM: phage major tail protein, phi13 family YP_001662892.1 TIGRFAM: phage tape measure protein YP_001662893.1 TIGRFAM: phage putative tail component YP_001662894.1 TIGRFAM: phage minor structural protein YP_001662898.1 TIGRFAM: toxin secretion/phage lysis holin; PFAM: Holin, toxin secretion/phage lysis YP_001662899.1 PFAM: N-acetylmuramoyl-L-alanine amidase, family 2; Sporulation domain protein YP_001662901.1 PFAM: Resolvase, N-terminal domain; Recombinase YP_001662902.1 PFAM: Recombinase YP_001662903.1 PFAM: Resolvase, N-terminal domain; Recombinase YP_001662904.1 PFAM: regulatory protein, ArsR YP_001662905.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; cadmium-translocating P-type ATPase; heavy metal translocating P-type ATPase; PFAM: Haloacid dehalogenase domain protein hydrolase; Heavy metal transport/detoxification protein; E1-E2 ATPase-associated domain protein YP_001662906.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001662909.1 TIGRFAM: alkylhydroperoxidase like protein, AhpD family; PFAM: Carboxymuconolactone decarboxylase YP_001662910.1 PFAM: Patatin YP_001662913.1 PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_001662914.1 PFAM: phosphoenolpyruvate carboxykinase (ATP) YP_001662916.1 PFAM: NUDIX hydrolase YP_001662917.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: pseudouridine synthase YP_001662918.1 PFAM: Radical SAM domain protein YP_001662919.1 PFAM: phosphoribulokinase/uridine kinase; SMART: AAA ATPase YP_001662922.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001662923.1 PFAM: iron dependent repressor YP_001662924.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001662925.1 PFAM: small acid-soluble spore protein, alpha/beta type YP_001662926.1 PFAM: peptidase S16, lon domain protein YP_001662927.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; domain of unknown function DUF1730 YP_001662928.1 TIGRFAM: endonuclease III; PFAM: helix-hairpin-helix motif; HhH-GPD family protein; SMART: iron-sulfur cluster loop YP_001662929.1 PFAM: VanW family protein; G5 domain protein YP_001662930.1 PFAM: ferric-uptake regulator YP_001662931.1 TIGRFAM: Cof-like hydrolase; HAD-superfamily hydrolase, subfamily IIB; PFAM: Haloacid dehalogenase domain protein hydrolase; sucrose-6F-phosphate phosphohydrolase; Haloacid dehalogenase domain protein hydrolase, type 3 YP_001662932.1 catalyzes the hydrolysis of acylphosphate YP_001662933.1 PFAM: putative sugar-binding domain protein YP_001662934.1 TIGRFAM: glyceraldehyde-3-phosphate dehydrogenase, type I; PFAM: glyceraldehyde 3-phosphate dehydrogenase YP_001662935.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_001662936.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_001662937.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_001662938.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_001662939.1 TIGRFAM: preprotein translocase, SecG subunit; PFAM: Preprotein translocase SecG subunit YP_001662940.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_001662941.1 synthesizes RNA primers at the replication forks YP_001662942.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_001662944.1 PFAM: protein of unknown function DUF633 YP_001662945.1 PFAM: protein of unknown function DUF34 YP_001662946.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_001662947.1 TIGRFAM: mannose-6-phosphate isomerase, class I; PFAM: mannose-6-phosphate isomerase, type I YP_001662948.1 PFAM: sodium/hydrogen exchanger YP_001662950.1 TIGRFAM: redox-active disulfide protein 2 YP_001662951.1 PFAM: permease YP_001662952.1 PFAM: regulatory protein, ArsR; Helix-turn-helix, type 11 domain protein YP_001662953.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase) YP_001662955.1 SMART: AAA ATPase YP_001662957.1 PFAM: GtrA family protein YP_001662958.1 PFAM: glycosyl transferase, family 39 YP_001662959.1 TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme; PFAM: deoxyribonuclease/rho motif-related TRAM; Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB YP_001662960.1 PFAM: histidine triad (HIT) protein YP_001662961.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_001662962.1 PFAM: GatB/Yqey domain protein YP_001662963.1 PFAM: Asparaginase/glutaminase YP_001662964.1 PFAM: protein of unknown function DUF1429 YP_001662965.1 PFAM: putative stage IV sporulation YqfD YP_001662966.1 PFAM: PhoH family protein; KH, type 1, domain protein YP_001662967.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; metal-dependent phosphohydrolase, 7TM intracellular region; metal-dependent phosphohydrolase, 7TM extracellular region; SMART: metal-dependent phosphohydrolase, HD region YP_001662968.1 PFAM: protein of unknown function UPF0054 YP_001662969.1 PFAM: phosphoesterase, PA-phosphatase related; diacylglycerol kinase YP_001662970.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_001662971.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_001662972.1 TIGRFAM: DNA repair protein RecO; PFAM: Recombination protein O, RecO YP_001662973.1 PFAM: ubiquitin-associated- domain-containing protein YP_001662974.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001662975.1 PFAM: CBS domain containing protein; regulatory protein, DeoR; Helix-turn-helix, type 11 domain protein YP_001662976.1 PFAM: protein of unknown function DUF299 YP_001662977.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_001662978.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001662979.1 TIGRFAM: VacB and RNase II family 3'-5' exoribonuclease; ribonuclease R; PFAM: ribonuclease II; RNA binding S1 domain protein; Ribonuclease B, OB region N-terminal domain; SMART: Cold shock protein YP_001662980.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_001662981.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001662982.1 PFAM: helix-turn-helix domain protein YP_001662986.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662988.1 PFAM: helix-turn-helix domain protein YP_001662990.1 PFAM: Radical SAM domain protein YP_001662991.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001662994.1 PFAM: transposase, IS4 family protein YP_001662995.1 PFAM: Radical SAM domain protein YP_001662996.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001662997.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001662998.1 PFAM: protein of unknown function DUF969 YP_001662999.1 PFAM: protein of unknown function DUF979 YP_001663000.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_001663002.1 PFAM: cyclic nucleotide-binding; regulatory protein, Crp YP_001663003.1 TIGRFAM: intracellular protease, PfpI family; PFAM: ThiJ/PfpI domain protein YP_001663004.1 PFAM: NADH:flavin oxidoreductase/NADH oxidase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase; HI0933 family protein YP_001663006.1 PFAM: aldehyde ferredoxin oxidoreductase; Aldehyde ferredoxin oxidoreductase-like YP_001663007.1 PFAM: Radical SAM domain protein YP_001663008.1 PFAM: thiamineS protein YP_001663009.1 PFAM: UBA/THIF-type NAD/FAD binding protein YP_001663010.1 TIGRFAM: molybdopterin-guanine dinucleotide biosynthesis protein B; PFAM: molybdopterin-guanine dinucleotide biosynthesis MobB region; Fe-S cluster domain protein YP_001663011.1 PFAM: extracellular solute-binding protein, family 1 YP_001663012.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663013.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001663014.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain YP_001663015.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV YP_001663016.1 TIGRFAM: molybdenum cofactor synthesis domain; PFAM: molybdopterin binding domain; MoeA domain protein, domain I and II; MoeA domain protein, domain IV YP_001663017.1 TIGRFAM: molybdenum cofactor biosynthesis protein A; PFAM: Radical SAM domain protein; molybdenum cofactor synthesis domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001663018.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_001663019.1 PFAM: MOSC domain containing protein YP_001663024.1 PFAM: MOSC domain containing protein YP_001663025.1 PFAM: helix-turn-helix, Fis-type YP_001663027.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001663028.1 PFAM: peptidase M48, Ste24p YP_001663029.1 PFAM: cobalamin B12-binding domain protein; Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001663030.1 PFAM: glycerophosphoryl diester phosphodiesterase YP_001663031.1 PFAM: major facilitator superfamily MFS_1 YP_001663032.1 PFAM: Appr-1-p processing domain protein YP_001663033.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_001663034.1 PFAM: sigmaK-factor processing regulatory BofA YP_001663037.1 PFAM: protein of unknown function DUF1294 YP_001663038.1 PFAM: beta-lactamase domain protein; flavodoxin/nitric oxide synthase YP_001663039.1 PFAM: low molecular weight phosphotyrosine protein phosphatase YP_001663041.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_001663042.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_001663043.1 PFAM: cyclase family protein YP_001663045.1 TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, beta subunit; PFAM: amino acid-binding ACT domain protein; serine dehydratase beta chain YP_001663046.1 TIGRFAM: L-serine dehydratase, iron-sulfur-dependent, alpha subunit; PFAM: serine dehydratase alpha chain YP_001663047.1 TIGRFAM: oligoendopeptidase F; PFAM: peptidase M3A and M3B, thimet/oligopeptidase F; Oligopeptidase F YP_001663048.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_001663049.1 PFAM: prephenate dehydratase; amino acid-binding ACT domain protein YP_001663050.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_001663051.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase; Prephenate dehydrogenase; TrkA-N domain protein YP_001663052.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_001663054.1 PFAM: Peptidoglycan-binding LysM; cell wall hydrolase, SleB YP_001663055.1 PFAM: protein of unknown function UPF0016 YP_001663056.1 PFAM: LmbE family protein YP_001663057.1 PFAM: ROK family protein YP_001663058.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_001663059.1 PFAM: cytochrome c biogenesis protein, transmembrane region YP_001663060.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001663061.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain YP_001663062.1 PFAM: aminotransferase, class V; Orn/Lys/Arg decarboxylase, major region; aromatic amino acid beta-eliminating lyase/threonine aldolase; Orn/Lys/Arg decarboxylase domain protein; Soluble liver antigen/liver pancreas antigen YP_001663063.1 PFAM: ferredoxin; Vitamin B12 dependent methionine synthase, activation region YP_001663065.1 TIGRFAM: SpoIID/LytB domain; PFAM: Peptidoglycan-binding domain 1 protein; Stage II sporulation D domain protein YP_001663066.1 TIGRFAM: small GTP-binding protein; PFAM: GTP-binding protein, HSR1-related YP_001663068.1 PFAM: NUDIX hydrolase YP_001663069.1 PFAM: protein of unknown function UPF0029 YP_001663070.1 PFAM: CoA-binding domain protein YP_001663073.1 TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001663074.1 PFAM: protein of unknown function DUF28 YP_001663075.1 PFAM: CheW domain protein YP_001663077.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_001663078.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_001663079.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_001663081.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_001663082.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_001663083.1 TIGRFAM: preprotein translocase, YajC subunit; PFAM: YajC family protein YP_001663085.1 PFAM: Radical SAM domain protein YP_001663087.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_001663088.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_001663089.1 TIGRFAM: 2-polyprenylphenol 6-hydroxylase; PFAM: ABC-1 domain protein YP_001663090.1 TIGRFAM: single-stranded-DNA-specific exonuclease RecJ; PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001663091.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_001663092.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_001663093.1 PFAM: beta-lactamase domain protein YP_001663095.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_001663096.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_001663097.1 PFAM: UBA/THIF-type NAD/FAD binding protein YP_001663098.1 PFAM: protein of unknown function DUF156 YP_001663099.1 TIGRFAM: thioredoxin; PFAM: Thioredoxin domain YP_001663100.1 PFAM: oxidoreductase domain protein; dihydrodipicolinate reductase; CoA-binding domain protein YP_001663102.1 PFAM: Pyridoxal-5'-phosphate-dependent enzyme, beta subunit YP_001663104.1 PFAM: cobalamin B12-binding domain protein YP_001663106.1 PFAM: alanine racemase domain protein YP_001663108.1 TIGRFAM: putative transcriptional regulator, Rrf2 family; PFAM: protein of unknown function UPF0074 YP_001663109.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_001663111.1 PFAM: protein of unknown function UPF0118 YP_001663112.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001663113.1 PFAM: protein of unknown function DUF965 YP_001663114.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_001663115.1 PFAM: protein of unknown function DUF1292 YP_001663116.1 PFAM: ferric-uptake regulator YP_001663117.1 PFAM: beta-lactamase domain protein; RNA-metabolising metallo-beta-lactamase YP_001663118.1 PFAM: protein of unknown function DUF964 YP_001663119.1 PFAM: protein of unknown function DUF988 YP_001663120.1 PFAM: aminodeoxychorismate lyase YP_001663121.1 PFAM: O-methyltransferase, family 3 YP_001663122.1 PFAM: peptidase U32 YP_001663123.1 PFAM: penicillin-binding protein, transpeptidase YP_001663124.1 sigma-28; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell after engulfment YP_001663125.1 TIGRFAM: hydrolase, HAD-superfamily, subfamily IIIA; HAD superfamily (subfamily IIIA) phosphatase, TIGR01668 YP_001663126.1 TIGRFAM: shikimate 5-dehydrogenase; PFAM: Shikimate/quinate 5-dehydrogenase; Shikimate dehydrogenase substrate binding, N-terminal domain protein YP_001663127.1 PFAM: type II secretion system protein E; General secretory system II, protein E domain protein; SMART: AAA ATPase YP_001663128.1 TIGRFAM: twitching motility protein; PFAM: type II secretion system protein E; SMART: AAA ATPase YP_001663129.1 PFAM: type II secretion system protein YP_001663131.1 PFAM: peptidase A24A, prepilin type IV; peptidase A24A domain protein YP_001663138.1 PFAM: Fimbrial assembly family protein YP_001663140.1 catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_001663141.1 PFAM: Xylose isomerase domain protein TIM barrel; SMART: AP endonuclease, family 2 YP_001663142.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_001663143.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_001663144.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_001663145.1 PFAM: creatinase; peptidase M24 YP_001663146.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_001663148.1 SMART: AAA ATPase YP_001663149.1 necessary for complete engulfment of forespore YP_001663150.1 PFAM: Stage III sporulation AC family protein YP_001663156.1 PFAM: protein of unknown function DUF322 YP_001663157.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_001663158.1 PFAM: tetrahydrofolate dehydrogenase/cyclohydrolase YP_001663159.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_001663160.1 TIGRFAM: exodeoxyribonuclease VII, small subunit; PFAM: Exonuclease VII, small subunit YP_001663161.1 PFAM: Polyprenyl synthetase YP_001663163.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_001663164.1 TIGRFAM: hemolysin A; PFAM: ribosomal RNA methyltransferase RrmJ/FtsJ; RNA-binding S4 domain protein YP_001663165.1 PFAM: ATP-NAD/AcoX kinase YP_001663166.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_001663167.1 TIGRFAM: DNA repair protein RecN; PFAM: SMC domain protein YP_001663168.1 PFAM: peptidase S55, SpoIVB YP_001663169.1 PFAM: response regulator receiver YP_001663170.1 PFAM: Thiamin pyrophosphokinase, catalytic region YP_001663172.1 PFAM: glycosyl transferase, family 2 YP_001663175.1 PFAM: NUDIX hydrolase YP_001663177.1 PFAM: protein of unknown function DUF95, transmembrane YP_001663178.1 TIGRFAM: tyrosine recombinase XerD; PFAM: phage integrase family protein; phage integrase domain protein SAM domain protein YP_001663179.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein YP_001663180.1 TIGRFAM: anti-anti-sigma factor; Anti-sigma factor antagonist; PFAM: Sulfate transporter/antisigma-factor antagonist STAS YP_001663181.1 binds to sigma F preventing its association with RNA polymerase during sporulation YP_001663182.1 PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2 YP_001663183.1 PFAM: protein of unknown function DUF1458 YP_001663184.1 PFAM: SpoVA protein YP_001663185.1 PFAM: Stage V sporulation AD family protein YP_001663186.1 PFAM: SpoVA protein YP_001663187.1 PFAM: Polynucleotide adenylyltransferase region YP_001663188.1 PFAM: peptidase M50 YP_001663189.1 PFAM: chromosome segregation and condensation protein ScpA YP_001663190.1 TIGRFAM: segregation and condensation protein B; PFAM: chromosome segregation and condensation protein ScpB YP_001663191.1 PFAM: protein of unknown function DUF1002 YP_001663194.1 PFAM: sodium:dicarboxylate symporter YP_001663195.1 PFAM: protein of unknown function DUF107 YP_001663196.1 PFAM: protein of unknown function DUF1432 YP_001663198.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein YP_001663199.1 PFAM: Oxidoreductase FAD-binding domain protein YP_001663200.1 PFAM: glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein YP_001663201.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001663203.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_001663204.1 TIGRFAM: putative agmatinase; PFAM: Arginase/agmatinase/formiminoglutamase YP_001663205.1 Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source YP_001663206.1 PFAM: Peptidoglycan-binding LysM YP_001663208.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_001663209.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001663210.1 PFAM: pyruvate flavodoxin/ferredoxin oxidoreductase domain protein YP_001663211.1 catalyzes the coenzyme A dependent formation of succinyl-CoA from 2-oxoglutarate and ferredoxin YP_001663212.1 TIGRFAM: pyruvate/ketoisovalerate oxidoreductase, gamma subunit; PFAM: pyruvate ferredoxin/flavodoxin oxidoreductase YP_001663213.1 PFAM: helix-turn-helix protein RpiR; sugar isomerase (SIS) YP_001663214.1 PFAM: Glu/Leu/Phe/Val dehydrogenase, C terminal; Glu/Leu/Phe/Val dehydrogenase, dimerisation region YP_001663215.1 PFAM: Arsenical pump membrane protein; Citrate transporter YP_001663216.1 PFAM: natural resistance-associated macrophage protein YP_001663217.1 PFAM: LamB/YcsF family protein YP_001663218.1 PFAM: Allophanate hydrolase subunit 1 YP_001663219.1 TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2 YP_001663220.1 PFAM: protein of unknown function DUF1445 YP_001663223.1 PFAM: Phosphoglycerate mutase YP_001663224.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; fumarate reductase/succinate dehydrogenase flavoprotein domain protein; HI0933 family protein; FAD dependent oxidoreductase YP_001663226.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_001663227.1 TIGRFAM: 1-acyl-sn-glycerol-3-phosphate acyltransferase; PFAM: phospholipid/glycerol acyltransferase YP_001663228.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_001663229.1 PFAM: RNA binding S1 domain protein YP_001663230.1 Decarboxylation of S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_001663231.1 PFAM: MCP methyltransferase, CheR-type YP_001663232.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_001663233.1 This protein performs the mismatch recognition step during the DNA repair process YP_001663234.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_001663235.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_001663236.1 TIGRFAM: RNA chaperone Hfq; PFAM: Like-Sm ribonucleoprotein, core YP_001663237.1 TIGRFAM: pyrroline-5-carboxylate reductase; PFAM: NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding YP_001663238.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_001663239.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_001663240.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; Aluminium resistance family protein YP_001663241.1 PFAM: AAA ATPase, central domain protein; SMART: AAA ATPase YP_001663242.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_001663243.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_001663244.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001663245.1 PFAM: Stage V sporulation protein S YP_001663246.1 PFAM: metallophosphoesterase YP_001663247.1 protein from Staphylococcus aureus has phosphodiesterase activity against 2'-3'-cAMP and 2'-3'-cGMP YP_001663248.1 PFAM: regulatory protein RecX YP_001663249.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_001663250.1 TIGRFAM: competence/damage-inducible protein CinA; PFAM: molybdopterin binding domain; CinA domain protein YP_001663251.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001663252.1 TIGRFAM: RNA modification enzyme, MiaB family; MiaB-like tRNA modifying enzyme YliG; PFAM: Radical SAM domain protein; Protein of unknown function UPF0004-like; SMART: Elongator protein 3/MiaB/NifB YP_001663253.1 PFAM: cell divisionFtsK/SpoIIIE; SMART: AAA ATPase YP_001663255.1 PFAM: peptidase S14, ClpP YP_001663256.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; diaminopimelate sensitive YP_001663257.1 PFAM: PRC-barrel domain protein YP_001663258.1 TIGRFAM: deoxyuridine 5'-triphosphate nucleotidohydrolase Dut; PFAM: deoxyUTP pyrophosphatase YP_001663259.1 PFAM: peptidase M16 domain protein YP_001663260.1 PFAM: polysaccharide deacetylase YP_001663261.1 PFAM: 3' exoribonuclease; RNA binding S1 domain protein; KH, type 1, domain protein; SMART: KH domain protein YP_001663262.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_001663263.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_001663264.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_001663265.1 PFAM: phosphoesterase, RecJ domain protein; phosphoesterase, DHHA1 YP_001663266.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_001663267.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_001663268.1 PFAM: ribosomal protein L7Ae/L30e/S12e/Gadd45 YP_001663269.1 PFAM: protein of unknown function DUF448 YP_001663270.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_001663271.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_001663272.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_001663273.1 PFAM: glycosyl transferase, family 2 YP_001663274.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_001663275.1 TIGRFAM: putative membrane-associated zinc metalloprotease; PFAM: PDZ/DHR/GLGF domain protein; peptidase M50 YP_001663276.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_001663277.1 PFAM: phosphatidate cytidylyltransferase YP_001663278.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_001663280.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_001663281.1 Catalyzes the phosphorylation of UMP to UDP YP_001663282.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_001663283.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_001663285.1 PFAM: protein of unknown function DUF342 YP_001663286.1 TIGRFAM: RNA polymerase sigma factor, FliA/WhiG family; PFAM: sigma-70 region 3 domain protein; sigma-70 region 2 domain protein; sigma-70 region 4 domain protein; Sigma-70, region 4 type 2 YP_001663287.1 catalyzes the conversion of glutamine residues to glutamate on methyl-accepting chemotaxis receptors YP_001663288.1 PFAM: CheC domain protein YP_001663289.1 PFAM: CheW domain protein YP_001663290.1 PFAM: CheW domain protein; ATP-binding region, ATPase domain protein domain protein; Signal transducing histidine kinase, homodimeric; Hpt domain protein; P2 response regulator binding domain protein YP_001663291.1 PFAM: CheB methylesterase YP_001663292.1 PFAM: type IV pilus assembly PilZ YP_001663293.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001663294.1 PFAM: GTP-binding signal recognition particle SRP54, G- domain; SMART: AAA ATPase YP_001663295.1 membrane protein involved in the flagellar export apparatus YP_001663296.1 TIGRFAM: flagellar biosynthetic protein FlhB; PFAM: type III secretion exporter YP_001663297.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_001663298.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_001663299.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_001663301.1 PFAM: response regulator receiver YP_001663302.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001663303.1 PFAM: surface presentation of antigens (SPOA) protein; flagellar motor switch protein FliM YP_001663304.1 PFAM: flagellar basal body-associated protein FliL YP_001663305.1 PFAM: flagellar FlbD family protein YP_001663306.1 PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein; flagellar basal body FlaE domain protein YP_001663307.1 TIGRFAM: flagellar operon protein YP_001663308.1 PFAM: flagellar hook capping protein YP_001663309.1 PFAM: flagellar hook-length control protein YP_001663311.1 TIGRFAM: flagellar export protein FliJ YP_001663312.1 TIGRFAM: ATPase, FliI/YscN family; flagellar protein export ATPase FliI; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; H+-transporting two-sector ATPase, alpha/beta subunit domain protein; SMART: AAA ATPase YP_001663314.1 One of three proteins involved in switching the direction of the flagellar rotation YP_001663315.1 TIGRFAM: flagellar M-ring protein FliF; PFAM: secretory protein YscJ/FliF family protein; Flagellar M-ring C-terminal domain protein YP_001663316.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_001663317.1 TIGRFAM: flagellar basal-body rod protein FlgC; PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein YP_001663318.1 TIGRFAM: flagellar basal-body rod protein FlgB; PFAM: flagellar basal body rod protein YP_001663319.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_001663320.1 heat shock protein involved in degradation of misfolded proteins YP_001663321.1 heat shock protein involved in degradation of misfolded proteins YP_001663322.1 TIGRFAM: DNA topoisomerase I; PFAM: TOPRIM domain protein; DNA topoisomerase, type IA, central domain protein; DNA topoisomerase, type IA, zn finger domain protein; SMART: DNA topoisomerase I, ATP-binding; DNA topoisomerase I, DNA-binding; Toprim sub domain protein YP_001663323.1 TIGRFAM: DNA protecting protein DprA; PFAM: SMF family protein YP_001663324.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_001663325.1 PFAM: protein of unknown function UPF0102 YP_001663326.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_001663327.1 PFAM: protein of unknown function DUF161 YP_001663328.1 TIGRFAM: Mg chelatase, subunit ChlI; PFAM: magnesium chelatase, ChlI subunit; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001663329.1 PFAM: GTP-binding protein, HSR1-related YP_001663330.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_001663331.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_001663332.1 Essential for efficient processing of 16S rRNA YP_001663334.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_001663335.1 TIGRFAM: signal recognition particle protein; PFAM: GTP-binding signal recognition particle SRP54, G- domain; Signal peptide binding (SRP54) M- domain protein; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001663336.1 PFAM: Bacterio-opsin activator, HTH domain protein; putative helix-turn-helix protein, YlxM/p13 family protein; Sigma-70, region 4 type 2 YP_001663337.1 TIGRFAM: signal recognition particle-docking protein FtsY; PFAM: GTP-binding signal recognition particle SRP54, G- domain; GTP-binding signal recognition particle SRP54, helical bundle; SMART: AAA ATPase YP_001663338.1 TIGRFAM: chromosome segregation protein SMC; PFAM: SMC domain protein; SMCs flexible hinge domain protein YP_001663340.1 PFAM: Stage V sporulation protein S YP_001663341.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001663342.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_001663343.1 PFAM: beta-ketoacyl synthase YP_001663344.1 carries the fatty acid chain in fatty acid biosynthesis YP_001663345.1 TIGRFAM: 3-oxoacyl-(acyl-carrier-protein) reductase; PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR; KR YP_001663346.1 TIGRFAM: malonyl CoA-acyl carrier protein transacylase; PFAM: acyl transferase domain protein YP_001663347.1 PFAM: 2-nitropropane dioxygenase, NPD YP_001663348.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_001663349.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_001663350.1 negative regulator of genes involved in fatty acid and phospholipid biosynthesis for gram positive bacteria YP_001663351.1 TIGRFAM: ribosomal protein L32; PFAM: ribosomal L32p protein YP_001663352.1 PFAM: protein of unknown function DUF177 YP_001663353.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001663354.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_001663355.1 PFAM: protein of unknown function DUF795 YP_001663356.1 PFAM: nucleoside recognition domain protein YP_001663358.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_001663359.1 TIGRFAM: putative methyltransferase; PFAM: conserved hypothetical protein 95; methyltransferase small YP_001663360.1 PFAM: small acid-soluble spore protein, alpha/beta type YP_001663361.1 PFAM: small acid-soluble spore protein, alpha/beta type YP_001663362.1 TIGRFAM: degV family protein; PFAM: DegV family protein YP_001663363.1 catalyzes branch migration in Holliday junction intermediates YP_001663364.1 PFAM: Dak phosphatase YP_001663365.1 PFAM: protein of unknown function DUF322 YP_001663366.1 required for 70S ribosome assembly YP_001663368.1 TIGRFAM: thiamine pyrophosphokinase; PFAM: Thiamin pyrophosphokinase, catalytic region YP_001663369.1 PFAM: ribulose-phosphate 3-epimerase; Orotidine 5'-phosphate decarboxylase YP_001663370.1 TIGRFAM: ribosome small subunit-dependent GTPase A; PFAM: GTPase EngC YP_001663371.1 PFAM: protein kinase; tyrosine protein kinase; PASTA domain containing protein; SMART: serine/threonine protein kinase YP_001663372.1 PFAM: protein phosphatase 2C domain protein YP_001663373.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_001663374.1 TIGRFAM: sun protein; putative RNA methylase, NOL1/NOP2/sun family; PFAM: Fmu (Sun) domain protein; NusB/RsmB/TIM44 YP_001663375.1 PFAM: peptidase, membrane zinc metallopeptidase, putative YP_001663376.1 PFAM: protein of unknown function DUF116 YP_001663377.1 TIGRFAM: methionyl-tRNA formyltransferase; PFAM: formyl transferase domain protein YP_001663378.1 PFAM: transposase IS116/IS110/IS902 family protein YP_001663379.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_001663380.1 TIGRFAM: primosomal protein N'; PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001663381.1 TIGRFAM: phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase; PFAM: flavoprotein; DNA/pantothenate metabolism flavoprotein domain protein YP_001663382.1 Promotes RNA polymerase assembly; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_001663383.1 Essential for recycling GMP and indirectly, cGMP YP_001663384.1 PFAM: protein of unknown function DUF370 YP_001663385.1 PFAM: YicC N-terminal domain protein; domain of unknown function DUF1732 YP_001663386.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_001663387.1 PFAM: major facilitator superfamily MFS_1 YP_001663389.1 PFAM: protein of unknown function DUF814; Fibronectin-binding A domain protein YP_001663390.1 TIGRFAM: 2'-5' RNA ligase; PFAM: 2',5' RNA ligase YP_001663391.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001663392.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663393.1 TIGRFAM: lipoprotein, YaeC family; PFAM: NLPA lipoprotein YP_001663394.1 PFAM: Asp/Glu racemase YP_001663396.1 TIGRFAM: cation diffusion facilitator family transporter; PFAM: cation efflux protein YP_001663398.1 TIGRFAM: phage SPO1 DNA polymerase-related protein; PFAM: Uracil-DNA glycosylase superfamily YP_001663399.1 TIGRFAM: hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit; PFAM: Fe-S type hydro-lyase tartrate/fumarate beta region YP_001663400.1 Catalyzes the reversible hydration of fumaric acid to yield I-malic acid YP_001663401.1 PFAM: thiamine biosynthesis protein; PP-loop domain protein YP_001663402.1 PFAM: S-layer domain protein domain protein; Fibronectin, type III domain protein; glycoside hydrolase, family 13 domain protein Ig domain protein region domain protein; alpha amylase, catalytic region; SMART: alpha amylase, C-terminal all-beta; alpha amylase, catalytic sub domain YP_001663404.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_001663405.1 PFAM: phosphoribosylglycinamide synthetase; protein of unknown function DUF201; D-alanine--D-alanine ligase domain protein; RimK domain protein ATP-grasp YP_001663407.1 PFAM: glycosyl transferase, group 1 YP_001663408.1 PFAM: transferase hexapeptide repeat containing protein; Nucleotidyl transferase YP_001663409.1 PFAM: glycosidase, PH1107-related; Glycosyl hydrolase family 32, N terminal domain protein YP_001663410.1 PFAM: glycosidase, PH1107-related YP_001663411.1 PFAM: glycoside hydrolase, family 5 YP_001663413.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001663414.1 TIGRFAM: oligopeptide/dipeptide ABC transporter, ATPase subunit; PFAM: ABC transporter related; Oligopeptide/dipeptide ABC transporter, C-terminal domain protein; SMART: AAA ATPase YP_001663415.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663416.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663417.1 PFAM: extracellular solute-binding protein, family 5 YP_001663419.1 PFAM: protein of unknown function DUF820 YP_001663420.1 PFAM: glycosidase, PH1107-related YP_001663423.1 PFAM: sigma-70 region 2 domain protein YP_001663425.1 PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001663426.1 PFAM: NAD-dependent epimerase/dehydratase; short-chain dehydrogenase/reductase SDR YP_001663428.1 PFAM: PP-loop domain protein YP_001663429.1 PFAM: protein of unknown function Met10; conserved hypothetical protein 95; SMART: PUA domain containing protein YP_001663430.1 PFAM: Peptidoglycan-binding domain 1 protein YP_001663431.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001663432.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits YP_001663433.1 PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein YP_001663434.1 TIGRFAM: orotidine 5'-phosphate decarboxylase; PFAM: Orotidine 5'-phosphate decarboxylase YP_001663435.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_001663436.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_001663437.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_001663438.1 PFAM: AIR synthase related protein domain protein YP_001663439.1 TIGRFAM: pseudouridine synthase, RluA family; PFAM: RNA-binding S4 domain protein; pseudouridine synthase YP_001663440.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_001663441.1 PFAM: GCN5-related N-acetyltransferase YP_001663442.1 PFAM: protein of unknown function DUF45 YP_001663444.1 PFAM: ATPase associated with various cellular activities, AAA_5 YP_001663445.1 PFAM: type III restriction enzyme, res subunit; SMART: DEAD-like helicases-like YP_001663446.1 PFAM: DNA methylase N-4/N-6 domain protein YP_001663448.1 PFAM: SNF2-related protein; helicase domain protein; type III restriction enzyme, res subunit; SMART: DEAD-like helicases-like YP_001663449.1 PFAM: protein of unknown function DUF324 YP_001663451.1 PFAM: protein of unknown function DUF324 YP_001663452.1 PFAM: protein of unknown function DUF324 YP_001663455.1 TIGRFAM: CRISPR-associated protein, TM1812 family; CRISPR-associated protein DxTHG motif YP_001663459.1 TIGRFAM: large conductance mechanosensitive channel protein; PFAM: large-conductance mechanosensitive channel YP_001663461.1 PFAM: protein of unknown function DUF81 YP_001663462.1 PFAM: nitroreductase YP_001663463.1 PFAM: sigma-70 region 2 domain protein; Sigma-70, region 4 type 2 YP_001663466.1 TIGRFAM: sodium ion-translocating decarboxylase, beta subunit; PFAM: Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit YP_001663467.1 PFAM: sodium pump decarboxylase, gamma subunit YP_001663468.1 PFAM: Glyoxalase/bleomycin resistance protein/dioxygenase YP_001663469.1 TIGRFAM: LAO/AO transport system ATPase; PFAM: ArgK protein; SMART: AAA ATPase YP_001663470.1 PFAM: cobalamin B12-binding domain protein YP_001663471.1 TIGRFAM: methylmalonyl-CoA mutase, large subunit; PFAM: methylmalonyl-CoA mutase YP_001663472.1 SMART: transglutaminase domain protein YP_001663473.1 PFAM: protein of unknown function UPF0047 YP_001663474.1 TIGRFAM: zinc finger, DksA/TraR C4-type YP_001663476.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; aromatic amino acid beta-eliminating lyase/threonine aldolase YP_001663477.1 PFAM: alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen; Redoxin domain protein YP_001663478.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_001663479.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_001663480.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_001663481.1 PFAM: N-(5'phosphoribosyl)anthranilate isomerase (PRAI) YP_001663482.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_001663483.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_001663484.1 TIGRFAM: glutamine amidotransferase of anthranilate synthase; PFAM: glutamine amidotransferase class-I YP_001663485.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_001663487.1 PFAM: protein of unknown function DUF77 YP_001663490.1 PFAM: Integrase, catalytic region YP_001663491.1 SMART: AAA ATPase YP_001663492.1 PFAM: Cys/Met metabolism pyridoxal-phosphate-dependent enzymes; Aluminium resistance family protein YP_001663494.1 PFAM: purine phosphorylase, family 2 YP_001663495.1 PFAM: cobalt transport protein YP_001663496.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001663497.1 TIGRFAM: putative translation initiation factor, aIF-2BI family; eIF-2B alpha/beta/delta-related uncharacterized protein; PFAM: initiation factor 2B related YP_001663498.1 PFAM: Alcohol dehydrogenase GroES domain protein YP_001663499.1 PFAM: regulatory protein GntR, HTH; UbiC transcription regulator-associated domain protein YP_001663500.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_001663501.1 PFAM: amidohydrolase; Amidohydrolase 3 YP_001663502.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_001663504.1 PFAM: DivIVA family protein YP_001663505.1 PFAM: RNA-binding S4 domain protein YP_001663506.1 PFAM: protein of unknown function YGGT YP_001663507.1 PFAM: protein of unknown function DUF552 YP_001663508.1 PFAM: alanine racemase domain protein YP_001663510.1 TIGRFAM: putative endoribonuclease L-PSP; PFAM: Endoribonuclease L-PSP YP_001663511.1 TIGRFAM: gluconate transporter; PFAM: Gluconate transporter; Citrate transporter; Na+/H+ antiporter NhaC YP_001663512.1 PFAM: glycerate kinase YP_001663513.1 PFAM: sugar diacid recognition domain protein YP_001663514.1 TIGRFAM: putative CoA-substrate-specific enzyme activase; PFAM: ATPase, BadF/BadG/BcrA/BcrD type; 2-hydroxyglutaryl-CoA dehydratase, D-component YP_001663515.1 PFAM: 2-hydroxyglutaryl-CoA dehydratase, D-component YP_001663519.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001663523.1 TIGRFAM: dihydroxyacetone kinase, L subunit; PFAM: Dak phosphatase YP_001663524.1 PFAM: Dak kinase YP_001663525.1 TIGRFAM: dihydroxyacetone kinase, phosphotransfer subunit; PFAM: PTS system fructose subfamily IIA component YP_001663526.1 TIGRFAM: xylulokinase; PFAM: carbohydrate kinase, FGGY YP_001663529.1 PFAM: aldehyde dehydrogenase YP_001663530.1 PFAM: Cupin 2, conserved barrel domain protein YP_001663531.1 PFAM: D-isomer specific 2-hydroxyacid dehydrogenase, catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding YP_001663532.1 PFAM: dihydrodipicolinate synthetase YP_001663533.1 TIGRFAM: ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase, class-II YP_001663534.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001663536.1 TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/galactose isomerase YP_001663537.1 PFAM: Transketolase, central region; Transketolase domain protein YP_001663538.1 PFAM: Transketolase domain protein YP_001663539.1 PFAM: Transaldolase YP_001663540.1 TIGRFAM: PAS sensor protein; PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; PAS fold domain protein; SMART: AAA ATPase YP_001663545.1 TIGRFAM: cobalamin biosynthesis protein CobD; PFAM: cobalamin biosynthesis protein CbiB YP_001663546.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001663547.1 PFAM: transport system permease protein YP_001663548.1 PFAM: periplasmic binding protein YP_001663549.1 PFAM: iron-containing alcohol dehydrogenase YP_001663550.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_001663552.1 PFAM: microcompartments protein YP_001663553.1 PFAM: microcompartments protein YP_001663554.1 TIGRFAM: MIP family channel protein; PFAM: major intrinsic protein YP_001663556.1 PFAM: aldehyde dehydrogenase YP_001663557.1 TIGRFAM: ATP--cobalamin adenosyltransferase; PFAM: cobalamin adenosyltransferase; protein of unknown function DUF336 YP_001663558.1 PFAM: Ethanolamine utilization protein EutN/carboxysome structural protein Ccml YP_001663560.1 TIGRFAM: ethanolamine utilization protein EutJ family protein; PFAM: cell division protein FtsA YP_001663561.1 PFAM: Propanediol utilization protein YP_001663562.1 PFAM: microcompartments protein YP_001663565.1 PFAM: dehydratase, small subunit YP_001663566.1 PFAM: dehydratase, medium subunit YP_001663567.1 PFAM: dehydratase, large subunit YP_001663568.1 PFAM: microcompartments protein YP_001663569.1 PFAM: microcompartments protein YP_001663571.1 PFAM: Integrase, catalytic region YP_001663572.1 PFAM: helix-turn-helix- domain containing protein, AraC type; response regulator receiver YP_001663573.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase internal region YP_001663575.1 PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein YP_001663576.1 PFAM: protein of unknown function DUF917 YP_001663577.1 PFAM: permease for cytosine/purines, uracil, thiamine, allantoin YP_001663578.1 PFAM: sigma-54 factor, interaction domain-containing protein; SMART: AAA ATPase YP_001663579.1 PFAM: protein of unknown function DUF917 YP_001663581.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001663582.1 PFAM: ABC transporter related YP_001663583.1 PFAM: regulatory protein, MarR YP_001663584.1 PFAM: SEC-C motif domain protein YP_001663586.1 PFAM: phospholipid/glycerol acyltransferase YP_001663587.1 PFAM: response regulator receiver YP_001663589.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_001663590.1 PFAM: protein of unknown function DUF205 YP_001663591.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_001663592.1 PFAM: protein of unknown function DUF512 YP_001663597.1 PFAM: Stage II sporulation P family protein YP_001663598.1 PFAM: protein of unknown function DUF1614 YP_001663599.1 TIGRFAM: phosphate transport system regulatory protein PhoU; PFAM: PhoU family protein YP_001663600.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_001663601.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstA; PFAM: binding-protein-dependent transport systems inner membrane component YP_001663602.1 TIGRFAM: phosphate ABC transporter, inner membrane subunit PstC; PFAM: binding-protein-dependent transport systems inner membrane component YP_001663603.1 TIGRFAM: phosphate binding protein; PFAM: extracellular solute-binding protein, family 1 YP_001663604.1 TIGRFAM: PAS sensor protein; PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein; PAS fold domain protein; SMART: PAS domain containing protein YP_001663605.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001663606.1 PFAM: ATP-cone domain protein YP_001663607.1 PFAM: PRC-barrel domain protein YP_001663608.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed after engulfment; this factor is involved in the transcription of small acid-soluble proteins involved in protecting the forespore chromatin YP_001663609.1 sigma-29; sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor is responsible for the expression of sporulation specific genes and is expressed in the mother cell at the onset of sporulation YP_001663610.1 PFAM: peptidase U4, sporulation factor SpoIIGA YP_001663611.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_001663612.1 PFAM: cell division protein FtsA YP_001663613.1 PFAM: protein of unknown function DUF1290 YP_001663614.1 PFAM: protein of unknown function DUF881 YP_001663615.1 PFAM: Polypeptide-transport-associated domain protein, FtsQ-type YP_001663616.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001663617.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_001663618.1 TIGRFAM: cell division protein FtsW; stage V sporulation protein E; PFAM: cell cycle protein YP_001663619.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_001663620.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_001663621.1 TIGRFAM: UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001663622.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_001663623.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain; PASTA domain containing protein YP_001663624.1 TIGRFAM: cell division protein FtsL; PFAM: Septum formation initiator YP_001663625.1 TIGRFAM: S-adenosyl-methyltransferase MraW; PFAM: methyltransferase YP_001663626.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_001663627.1 PFAM: peptidase M16 domain protein YP_001663628.1 PFAM: peptidase M16 domain protein YP_001663630.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_001663632.1 Required for the synthesis of the thiazole moiety YP_001663633.1 PFAM: aminotransferase, class V; aromatic amino acid beta-eliminating lyase/threonine aldolase; aminotransferase, class I and II YP_001663634.1 PFAM: protein of unknown function DUF156 YP_001663635.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001663638.1 PFAM: biotin/lipoyl attachment domain-containing protein; catalytic domain of components of various dehydrogenase complexes; E3 binding domain protein YP_001663639.1 PFAM: ATP-NAD/AcoX kinase YP_001663640.1 PFAM: Transketolase, central region; Transketolase domain protein YP_001663641.1 PFAM: dehydrogenase, E1 component YP_001663643.1 TIGRFAM: PAS sensor protein; PFAM: sigma-54 factor, interaction domain-containing protein; helix-turn-helix, Fis-type; GAF domain protein; PAS fold domain protein; SMART: PAS domain containing protein; AAA ATPase YP_001663644.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_001663645.1 TIGRFAM: lipoate-protein ligase B; PFAM: biotin/lipoate A/B protein ligase YP_001663646.1 TIGRFAM: dihydrolipoamide dehydrogenase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; glucose-inhibited division protein A; pyridine nucleotide-disulphide oxidoreductase dimerisation region; HI0933 family protein YP_001663649.1 catalyzes the removal of amino acids from the N termini of peptides YP_001663650.1 PFAM: regulatory protein, LuxR; response regulator receiver; Sigma-70, region 4 type 2 YP_001663651.1 PFAM: ATP-binding region, ATPase domain protein domain protein; Sensor DegS domain protein; histidine kinase, dimerisation and phosphoacceptor region YP_001663653.1 PFAM: protein of unknown function DUF523 YP_001663654.1 MutS2; MutS-II; involved in blocking homologous and homeologous recombination; has ATPase activity stimulated by recombination intermediates; inhibits DNA strand exchange YP_001663655.1 PFAM: peptidase U32 YP_001663656.1 PFAM: protein of unknown function DUF710 YP_001663657.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_001663658.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_001663659.1 PFAM: tRNA/rRNA methyltransferase (SpoU); RNA 2-O ribose methyltransferase, substrate binding YP_001663660.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_001663661.1 PFAM: ribosomal protein L35 YP_001663662.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_001663663.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_001663664.1 PFAM: major facilitator superfamily MFS_1 YP_001663665.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_001663669.1 TIGRFAM: diguanylate cyclase; PFAM: GGDEF domain containing protein; response regulator receiver YP_001663670.1 PFAM: Thioredoxin domain YP_001663671.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_001663672.1 PFAM: Cold-shock protein, DNA-binding; SMART: Cold shock protein YP_001663673.1 PFAM: Silent information regulator protein Sir2 YP_001663675.1 PFAM: nitrogen-fixing NifU domain protein YP_001663676.1 PFAM: GAF domain protein YP_001663677.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_001663678.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_001663679.1 PFAM: regulatory protein, ArsR; Helix-turn-helix, type 11 domain protein YP_001663680.1 PFAM: permease YP_001663681.1 TIGRFAM: redox-active disulfide protein 2 YP_001663682.1 PFAM: protein of unknown function DUF711 YP_001663683.1 PFAM: amino acid-binding ACT domain protein YP_001663684.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_001663685.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_001663686.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_001663687.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_001663688.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_001663689.1 TIGRFAM: heat-inducible transcription repressor HrcA; PFAM: Negative regulator of class I heat shock protein YP_001663690.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_001663691.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_001663695.1 PFAM: Stage II sporulation P family protein YP_001663696.1 Initiates the rapid degradation of small, acid-soluble proteins during spore germination YP_001663698.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_001663699.1 TIGRFAM: DNA polymerase III, delta subunit; PFAM: DNA polymerase III, delta YP_001663700.1 TIGRFAM: DNA internalization-related competence protein ComEC/Rec2; PFAM: beta-lactamase domain protein; ComEC/Rec2-related protein YP_001663701.1 PFAM: beta-lactamase domain protein YP_001663702.1 PFAM: Haloacid dehalogenase domain protein hydrolase YP_001663703.1 PFAM: protein of unknown function DUF1393 YP_001663707.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_001663708.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001663710.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_001663711.1 PFAM: phosphatidylglycerophosphatase A YP_001663712.1 TIGRFAM: competence protein ComEA helix-hairpin-helix repeat protein; PFAM: helix-hairpin-helix motif; SMART: Helix-hairpin-helix DNA-binding, class 1 YP_001663713.1 PFAM: peptidase S11, D-alanyl-D-alanine carboxypeptidase 1; Penicillin-binding protein 5 domain protein YP_001663714.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_001663716.1 PFAM: NAD/NADP octopine/nopaline dehydrogenase; NADP oxidoreductase, coenzyme F420-dependent; 6-phosphogluconate dehydrogenase, NAD-binding; NAD-dependent glycerol-3-phosphate dehydrogenase domain protein YP_001663717.1 PFAM: YheO domain protein YP_001663718.1 TIGRFAM: iojap-like protein; PFAM: Iojap-related protein YP_001663719.1 TIGRFAM: metal dependent phophohydrolase; PFAM: metal-dependent phosphohydrolase, HD sub domain; SMART: metal-dependent phosphohydrolase, HD region YP_001663720.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_001663721.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_001663723.1 involved in the peptidyltransferase reaction during translation YP_001663724.1 PFAM: protein of unknown function DUF464 YP_001663725.1 PFAM: ribosomal protein L21 YP_001663727.1 PFAM: protein of unknown function DUF988 YP_001663728.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis YP_001663729.1 TIGRFAM: ribonuclease, Rne/Rng family; PFAM: RNA binding S1 domain protein YP_001663731.1 PFAM: Radical SAM domain protein; SMART: Elongator protein 3/MiaB/NifB YP_001663732.1 PFAM: peptidase M50 YP_001663733.1 PFAM: peptidase M23B YP_001663734.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_001663735.1 TIGRFAM: rod shape-determining protein RodA; PFAM: cell cycle protein YP_001663736.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_001663737.1 TIGRFAM: septum site-determining protein MinD; PFAM: Cobyrinic acid a,c-diamide synthase YP_001663738.1 blocks the formation of polar Z-ring septums YP_001663739.1 PFAM: penicillin-binding protein, transpeptidase; Penicillin-binding protein, dimerisation domain YP_001663741.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_001663742.1 functions in MreBCD complex in some organisms YP_001663743.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_001663744.1 TIGRFAM: maf protein; PFAM: Maf family protein YP_001663746.1 TIGRFAM: hydrogenase, Fe-only; PFAM: ferredoxin; 4Fe-4S ferredoxin, iron-sulfur binding domain protein; iron hydrogenase, small subunit; hydrogenase large subunit domain protein YP_001663747.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Respiratory-chain NADH dehydrogenase domain, 51 kDa subunit YP_001663749.1 PFAM: ATP-binding region, ATPase domain protein domain protein YP_001663750.1 PFAM: NADH dehydrogenase (ubiquinone), 24 kDa subunit YP_001663751.1 PFAM: PHP C-terminal domain protein; SMART: phosphoesterase PHP domain protein YP_001663753.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein; Fe-S cluster domain protein YP_001663754.1 PFAM: ATP-binding region, ATPase domain protein domain protein YP_001663757.1 PFAM: Lytic transglycosylase, catalytic YP_001663758.1 TIGRFAM: small GTP-binding protein; GTP-binding protein TypA; PFAM: elongation factor G domain protein; protein synthesis factor, GTP-binding; elongation factor Tu, domain 2 protein YP_001663759.1 PFAM: NLP/P60 protein; SH3 domain protein; protein of unknown function DUF1058; Variant SH3 domain protein; SH3, type 3 domain protein; SMART: SH3 domain protein domain protein YP_001663760.1 PFAM: extracellular solute-binding protein, family 5 YP_001663761.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_001663762.1 PFAM: Lytic transglycosylase, catalytic YP_001663763.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_001663764.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_001663765.1 PFAM: PspC domain protein YP_001663767.1 PFAM: glycoside hydrolase, family 18; SMART: chitinase II YP_001663769.1 PFAM: conserved hypothetical protein 1440 YP_001663771.1 TIGRFAM: prevent-host-death family protein; PFAM: protein of unknown function DUF172 YP_001663772.1 PFAM: protein of unknown function DUF86 YP_001663773.1 PFAM: DNA polymerase, beta domain protein region YP_001663778.1 catalyzes the degradation of histidine to urocanate and ammmonia YP_001663780.1 PFAM: protein of unknown function UPF0180 YP_001663781.1 PFAM: peptidase M23B YP_001663782.1 PFAM: protein of unknown function DUF583 YP_001663783.1 PFAM: regulatory protein GntR, HTH; aminotransferase, class I and II YP_001663784.1 TIGRFAM: isoaspartyl dipeptidase; PFAM: amidohydrolase; Amidohydrolase 3 YP_001663785.1 PFAM: response regulator receiver; ANTAR domain protein YP_001663786.1 TIGRFAM: glutamine synthetase, type I; PFAM: glutamine synthetase, catalytic region; glutamine synthetase, beta-Grasp YP_001663788.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001663789.1 PFAM: ABC transporter, transmembrane region; ABC transporter related; SMART: AAA ATPase YP_001663791.1 TIGRFAM: aspartate-semialdehyde dehydrogenase; PFAM: Semialdehyde dehydrogenase, NAD - binding; Semialdehyde dehydrogenase, dimerisation region YP_001663792.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_001663793.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_001663794.1 PFAM: transferase hexapeptide repeat containing protein; Tetrahydrodipicolinate succinyltransferase N-terminal domain protein YP_001663795.1 PFAM: ATP:corrinoid adenosyltransferase BtuR/CobO/CobP YP_001663796.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_001663797.1 PFAM: Mur ligase, middle domain protein YP_001663798.1 PFAM: Peptidoglycan-binding LysM; cell wall hydrolase, SleB YP_001663799.1 PFAM: sigma-54 factor, interaction domain-containing protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001663800.1 PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin; peptidase domain protein YP_001663801.1 PFAM: glycoside hydrolase, family 65 domain protein; glycoside hydrolase family 65, central catalytic; glycoside hydrolase family 65 domain protein YP_001663802.1 PFAM: extracellular solute-binding protein, family 1 YP_001663803.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663804.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663805.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001663806.1 TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 3; beta-phosphoglucomutase; beta-phosphoglucomutase family hydrolase; PFAM: Haloacid dehalogenase domain protein hydrolase YP_001663807.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663808.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663809.1 PFAM: extracellular solute-binding protein, family 1 YP_001663810.1 PFAM: glycoside hydrolase, family 65 domain protein; glycoside hydrolase family 65, central catalytic; glycoside hydrolase family 65 domain protein YP_001663811.1 PFAM: regulatory protein, LacI; periplasmic binding protein/LacI transcriptional regulator YP_001663812.1 PFAM: 4Fe-4S ferredoxin, iron-sulfur binding domain protein YP_001663813.1 PFAM: small acid-soluble spore protein, alpha/beta type YP_001663817.1 TIGRFAM: FolC bifunctional protein; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase, middle domain protein YP_001663818.1 PFAM: GCN5-related N-acetyltransferase YP_001663819.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_001663820.1 PFAM: protein of unknown function DUF151 YP_001663821.1 PFAM: BioY protein YP_001663824.1 PFAM: response regulator receiver; transcriptional regulator domain protein YP_001663825.1 PFAM: ATP-binding region, ATPase domain protein domain protein; histidine kinase, HAMP region domain protein; histidine kinase A domain protein domain protein YP_001663827.1 PFAM: ExsB family protein; PP-loop domain protein YP_001663828.1 TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase YP_001663830.1 PFAM: RNA-directed DNA polymerase (Reverse transcriptase); Group II intron, maturase-specific domain protein YP_001663831.1 PFAM: protein of unknown function DUF458 YP_001663832.1 TIGRFAM: drug resistance transporter, EmrB/QacA subfamily; PFAM: major facilitator superfamily MFS_1 YP_001663833.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_001663835.1 TIGRFAM: ATPase, P-type (transporting), HAD superfamily, subfamily IC; PFAM: cation transporting ATPase domain protein domain protein; Haloacid dehalogenase domain protein hydrolase; cation transporting ATPase domain protein; E1-E2 ATPase-associated domain protein YP_001663838.1 TIGRFAM: cell envelope-related function transcriptional attenuator, LytR/CpsA family; PFAM: cell envelope-related transcriptional attenuator YP_001663839.1 PFAM: PHP C-terminal domain protein YP_001663840.1 TIGRFAM: capsular exopolysaccharide family YP_001663841.1 PFAM: lipopolysaccharide biosynthesis protein YP_001663842.1 TIGRFAM: UTP-glucose-1-phosphate uridylyltransferase; PFAM: Nucleotidyl transferase YP_001663843.1 PFAM: phosphoglucomutase/phosphomannomutase C terminal; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III YP_001663844.1 PFAM: transcription antitermination protein NusG; KOW domain protein; SMART: NGN domain protein; KOW (Kyrpides, Ouzounis, Woese) domain protein YP_001663845.1 PFAM: SNO glutamine amidotransferase; CobB/CobQ domain protein glutamine amidotransferase YP_001663846.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_001663847.1 PFAM: protein of unknown function DUF86 YP_001663848.1 PFAM: DNA polymerase, beta domain protein region YP_001663854.1 PFAM: DNA polymerase, beta domain protein region YP_001663855.1 PFAM: natural resistance-associated macrophage protein YP_001663856.1 PFAM: Positive regulator of sigma(E), RseC/MucC YP_001663857.1 pyrophosphate-energized proton pump; pyrophosphate-energized inorganic pyrophosphatase; H+-PPase; can cleave pyrophosphate to two phosphates; can generate a proton motive force and drive pyrophosphate synthesis when PMF is sufficient YP_001663858.1 PFAM: putative small multi-drug export YP_001663859.1 PFAM: aldo/keto reductase YP_001663860.1 TIGRFAM: phosphodiesterase, MJ0936 family; PFAM: metallophosphoesterase YP_001663861.1 PFAM: LemA family protein YP_001663862.1 putative metalloprotease YP_001663865.1 TIGRFAM: addiction module toxin, Txe/YoeB family; PFAM: Addiction module toxin, Txe/YoeB YP_001663866.1 TIGRFAM: prevent-host-death family protein; PFAM: protein of unknown function DUF172 YP_001663869.1 PFAM: ATPase associated with various cellular activities, AAA_3; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001663871.1 PFAM: helicase domain protein; type III restriction enzyme, res subunit; DEAD/DEAH box helicase domain protein; SMART: DEAD-like helicases-like YP_001663873.1 PFAM: protein of unknown function DUF820 YP_001663874.1 PFAM: plasmid pRiA4b ORF-3 family protein YP_001663875.1 PFAM: protein of unknown function DUF1648 YP_001663876.1 PFAM: lipopolysaccharide biosynthesis protein YP_001663877.1 PFAM: Nucleotidyl transferase YP_001663878.1 PFAM: sugar transferase YP_001663879.1 PFAM: UDP-glucose/GDP-mannose dehydrogenase YP_001663880.1 PFAM: glycosyl transferase, group 1 YP_001663882.1 PFAM: glycosyl transferase, group 1 YP_001663883.1 PFAM: glycosyl transferase, group 1 YP_001663884.1 PFAM: glycosyl transferase, group 1 YP_001663885.1 PFAM: O-antigen polymerase YP_001663887.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001663889.1 PFAM: protein of unknown function DUF1703 YP_001663890.1 PFAM: protein of unknown function DUF1703 YP_001663891.1 TIGRFAM: magnesium transporter; PFAM: CBS domain containing protein; MgtE integral membrane region; MgtE intracellular region YP_001663892.1 PFAM: membrane lipoprotein lipid attachment site YP_001663893.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001663894.1 PFAM: binding-protein-dependent transport systems inner membrane component YP_001663895.1 TIGRFAM: NAD+ synthetase; PFAM: Nitrilase/cyanide hydratase and apolipoprotein N-acyltransferase; NAD+ synthase YP_001663896.1 PFAM: protein of unknown function DUF6, transmembrane YP_001663897.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_001663898.1 TIGRFAM: ATP-dependent protease La; PFAM: peptidase S16, lon domain protein; AAA ATPase, central domain protein; ATPase associated with various cellular activities, AAA_5; SMART: AAA ATPase YP_001663899.1 binds and unfolds substrates as part of the ClpXP protease YP_001663900.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_001663901.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_001663902.1 PFAM: Integrase, catalytic region YP_001663903.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_001663904.1 TIGRFAM: histidinol phosphate phosphatase HisJ family; PFAM: PHP C-terminal domain protein YP_001663905.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_001663906.1 PFAM: aminotransferase, class V YP_001663907.1 PFAM: peptidase S8 and S53, subtilisin, kexin, sedolisin; SH3 domain protein; protease-associated PA domain protein; Ig domain protein, group 2 domain protein; protein of unknown function DUF1034; protein of unknown function DUF1058; Variant SH3 domain protein; SH3, type 3 domain protein; SMART: SH3 domain protein domain protein YP_001663908.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_001663909.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_001663910.1 PFAM: homoserine dehydrogenase; amino acid-binding ACT domain protein; homoserine dehydrogenase, NAD-binding YP_001663912.1 PFAM: beta-lactamase domain protein YP_001663913.1 TIGRFAM: CRISPR-associated protein Cas2; PFAM: protein of unknown function DUF196 YP_001663914.1 TIGRFAM: CRISPR-associated protein Cas1; PFAM: protein of unknown function DUF48 YP_001663915.1 TIGRFAM: CRISPR-associated protein Cas4; PFAM: protein of unknown function DUF83 YP_001663916.1 PFAM: peptidase S51, dipeptidase E YP_001663917.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001663918.1 PFAM: transposase, IS111A/IS1328/IS1533; transposase IS116/IS110/IS902 family protein YP_001663919.1 TIGRFAM: CRISPR-associated helicase Cas3; CRISPR-associated HD domain protein; PFAM: helicase domain protein; SMART: DEAD-like helicases-like YP_001663920.1 TIGRFAM: CRISPR-associated protein Cas5, Hmari subtype; CRISPR-associated protein Cas5 YP_001663921.1 TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein, Csh2 family; PFAM: CRISPR-associated protein TM1801 YP_001663922.1 TIGRFAM: CRISPR-associated protein, TM1802 family; CRISPR-associated protein, Csh1 family YP_001663923.1 TIGRFAM: CRISPR-associated protein Cas6; PFAM: protein of unknown function DUF57 YP_001663924.1 TIGRFAM: SUF system FeS assembly protein, NifU family; PFAM: nitrogen-fixing NifU domain protein YP_001663925.1 TIGRFAM: cysteine desulfurase, SufS subfamily; PFAM: aminotransferase, class V YP_001663926.1 PFAM: SufBD protein YP_001663927.1 TIGRFAM: FeS assembly protein SufB; PFAM: SufBD protein YP_001663928.1 TIGRFAM: FeS assembly ATPase SufC; PFAM: ABC transporter related; SMART: AAA ATPase YP_001663929.1 PFAM: chaperonin Cpn10 YP_001663930.1 TIGRFAM: glutaredoxin-like protein, YruB-family; PFAM: glutaredoxin YP_001663934.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_001663935.1 PFAM: protein of unknown function DUF163 YP_001663936.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_001663938.1 PFAM: peptidase S1 and S6, chymotrypsin/Hap; PDZ/DHR/GLGF domain protein YP_001663939.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_001663941.1 PFAM: Peptidoglycan-binding LysM; peptidase M23B; G5 domain protein YP_001663942.1 TIGRFAM: primosome, DnaD subunit; PFAM: DnaD and phage-associated region YP_001663943.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_001663944.1 PFAM: peptidase M1, membrane alanine aminopeptidase YP_001663945.1 PFAM: uncharacterised conserved protein UCP033563 YP_001663946.1 TIGRFAM: transposase, IS605 OrfB family; PFAM: putative transposase, IS891/IS1136/IS1341 family; transposase, IS605 OrfB YP_001663947.1 PFAM: beta-lactamase domain protein YP_001663949.1 PFAM: peptidase S9, prolyl oligopeptidase active site domain protein YP_001663950.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_001663951.1 PFAM: FAD dependent oxidoreductase; FAD-dependent pyridine nucleotide-disulphide oxidoreductase YP_001663952.1 PFAM: histidine kinase, HAMP region domain protein; chemotaxis sensory transducer YP_001663954.1 PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; pyridine nucleotide-disulphide oxidoreductase dimerisation region; FAD dependent oxidoreductase YP_001663955.1 TIGRFAM: oligoendopeptidase F; PFAM: peptidase M3A and M3B, thimet/oligopeptidase F; Oligopeptidase F YP_001663956.1 PFAM: Chromate transporter YP_001663957.1 PFAM: Chromate transporter YP_001663958.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex YP_001663959.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex YP_001663960.1 TIGRFAM: ATP synthase, A subunit; PFAM: H+-transporting two-sector ATPase, alpha/beta subunit, central region; H+-transporting two-sector ATPase, alpha/beta subunit domain protein YP_001663961.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex YP_001663962.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the C subunit is part of the catalytic core of the ATP synthase complex YP_001663963.1 PFAM: H+-transporting two-sector ATPase, E subunit YP_001663964.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits YP_001663965.1 PFAM: V-type ATPase, 116 kDa subunit YP_001663967.1 TIGRFAM: uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease YP_001663971.1 PFAM: ABC transporter related; SMART: AAA ATPase YP_001663978.1 SMART: phosphoesterase PHP domain protein YP_001663982.1 PFAM: cyclic nucleotide-binding; regulatory protein, Crp YP_001663983.1 TIGRFAM: replicative DNA helicase; PFAM: DnaB domain protein helicase, N-terminal domain protein; DnaB domain protein helicase, C-terminal domain protein; SMART: AAA ATPase YP_001663984.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_001663987.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_001663988.1 TIGRFAM: single-strand binding protein; PFAM: single-strand binding protein/Primosomal replication protein n YP_001663989.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_001663990.1 PFAM: protein of unknown function DUF951 YP_001663991.1 PFAM: MscS Mechanosensitive ion channel YP_001663992.1 PFAM: protein of unknown function DUF1256 YP_001663993.1 catalyze the formation of cyanophycin which may act to store excess nitrogen YP_001663994.1 TIGRFAM: cyanophycinase; PFAM: peptidase S51, dipeptidase E YP_001663995.1 PFAM: diacylglycerol kinase, catalytic region YP_001663997.1 TIGRFAM: cysteine desulfurase family protein; PFAM: aminotransferase, class V YP_001663998.1 TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease YP_001663999.1 PFAM: Cobyrinic acid a,c-diamide synthase YP_001664000.1 TIGRFAM: parB-like partition protein; PFAM: ParB domain protein nuclease YP_001664001.1 PFAM: NUDIX hydrolase YP_001664002.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_001664003.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_001664004.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_001664005.1 PFAM: single-stranded nucleic acid binding R3H domain protein YP_001664006.1 PFAM: 60 kDa inner membrane insertion protein YP_001664007.1 PFAM: protein of unknown function DUF37 YP_001664008.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_001664009.1 in Escherichia coli transcription of this gene is enhanced by polyamines