-- dump date   	20120504_163916
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
399726000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
399726000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
399726000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726000004	Walker A motif; other site
399726000005	ATP binding site [chemical binding]; other site
399726000006	Walker B motif; other site
399726000007	arginine finger; other site
399726000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
399726000009	DnaA box-binding interface [nucleotide binding]; other site
399726000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
399726000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
399726000012	putative DNA binding surface [nucleotide binding]; other site
399726000013	dimer interface [polypeptide binding]; other site
399726000014	beta-clamp/clamp loader binding surface; other site
399726000015	beta-clamp/translesion DNA polymerase binding surface; other site
399726000016	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
399726000017	RNA binding surface [nucleotide binding]; other site
399726000018	recombination protein F; Reviewed; Region: recF; PRK00064
399726000019	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726000020	Walker A/P-loop; other site
399726000021	ATP binding site [chemical binding]; other site
399726000022	Q-loop/lid; other site
399726000023	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726000024	ABC transporter signature motif; other site
399726000025	Walker B; other site
399726000026	D-loop; other site
399726000027	H-loop/switch region; other site
399726000028	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
399726000029	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
399726000030	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
399726000031	trimer interface [polypeptide binding]; other site
399726000032	active site
399726000033	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
399726000034	catalytic site [active]
399726000035	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
399726000036	catalytic triad [active]
399726000037	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726000038	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
399726000039	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
399726000040	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726000041	Mg2+ binding site [ion binding]; other site
399726000042	G-X-G motif; other site
399726000043	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
399726000044	anchoring element; other site
399726000045	dimer interface [polypeptide binding]; other site
399726000046	ATP binding site [chemical binding]; other site
399726000047	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
399726000048	active site
399726000049	putative metal-binding site [ion binding]; other site
399726000050	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
399726000051	DNA gyrase subunit A; Validated; Region: PRK05560
399726000052	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187
399726000053	CAP-like domain; other site
399726000054	active site
399726000055	primary dimer interface [polypeptide binding]; other site
399726000056	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
399726000057	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
399726000058	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
399726000059	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
399726000060	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
399726000061	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
399726000062	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
399726000063	active site
399726000064	FMN binding site [chemical binding]; other site
399726000065	substrate binding site [chemical binding]; other site
399726000066	homotetramer interface [polypeptide binding]; other site
399726000067	catalytic residue [active]
399726000068	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
399726000069	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
399726000070	putative valine binding site [chemical binding]; other site
399726000071	dimer interface [polypeptide binding]; other site
399726000072	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
399726000073	ketol-acid reductoisomerase; Provisional; Region: PRK05479
399726000074	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000075	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
399726000076	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
399726000077	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
399726000078	active site
399726000079	catalytic residues [active]
399726000080	metal binding site [ion binding]; metal-binding site
399726000081	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
399726000082	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
399726000083	substrate binding site [chemical binding]; other site
399726000084	ligand binding site [chemical binding]; other site
399726000085	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
399726000086	substrate binding site [chemical binding]; other site
399726000087	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
399726000088	tartrate dehydrogenase; Provisional; Region: PRK08194
399726000089	Dehydratase family; Region: ILVD_EDD; cl00340
399726000090	6-phosphogluconate dehydratase; Region: edd; TIGR01196
399726000091	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
399726000092	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
399726000093	PYR/PP interface [polypeptide binding]; other site
399726000094	dimer interface [polypeptide binding]; other site
399726000095	TPP binding site [chemical binding]; other site
399726000096	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815
399726000097	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
399726000098	TPP-binding site [chemical binding]; other site
399726000099	dimer interface [polypeptide binding]; other site
399726000100	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
399726000101	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
399726000102	catalytic motif [active]
399726000103	Zn binding site [ion binding]; other site
399726000104	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161
399726000105	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
399726000106	Lumazine binding domain; Region: Lum_binding; pfam00677
399726000107	Lumazine binding domain; Region: Lum_binding; pfam00677
399726000108	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
399726000109	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336
399726000110	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
399726000111	dimerization interface [polypeptide binding]; other site
399726000112	active site
399726000113	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
399726000114	homopentamer interface [polypeptide binding]; other site
399726000115	active site
399726000116	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
399726000117	Domain of unknown function DUF20; Region: UPF0118; pfam01594
399726000118	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
399726000119	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
399726000120	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
399726000121	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
399726000122	Catalytic site [active]
399726000123	seryl-tRNA synthetase; Provisional; Region: PRK05431
399726000124	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
399726000125	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770
399726000126	dimer interface [polypeptide binding]; other site
399726000127	active site
399726000128	motif 1; other site
399726000129	motif 2; other site
399726000130	motif 3; other site
399726000131	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
399726000132	active site
399726000133	catalytic triad [active]
399726000134	oxyanion hole [active]
399726000135	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
399726000136	nucleoside/Zn binding site; other site
399726000137	dimer interface [polypeptide binding]; other site
399726000138	catalytic motif [active]
399726000139	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726000140	dimerization interface [polypeptide binding]; other site
399726000141	PAS domain S-box; Region: sensory_box; TIGR00229
399726000142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
399726000143	putative active site [active]
399726000144	heme pocket [chemical binding]; other site
399726000145	GAF domain; Region: GAF_2; pfam13185
399726000146	GAF domain; Region: GAF; cl15785
399726000147	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726000148	Zn2+ binding site [ion binding]; other site
399726000149	Mg2+ binding site [ion binding]; other site
399726000150	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
399726000151	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726000152	Walker A motif; other site
399726000153	ATP binding site [chemical binding]; other site
399726000154	Walker B motif; other site
399726000155	arginine finger; other site
399726000156	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
399726000157	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
399726000158	recombination protein RecR; Reviewed; Region: recR; PRK00076
399726000159	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
399726000160	RecR protein; Region: RecR; pfam02132
399726000161	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
399726000162	putative active site [active]
399726000163	putative metal-binding site [ion binding]; other site
399726000164	tetramer interface [polypeptide binding]; other site
399726000165	CrcB-like protein; Region: CRCB; cl09114
399726000166	CrcB-like protein; Region: CRCB; cl09114
399726000167	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726000168	Zn2+ binding site [ion binding]; other site
399726000169	Mg2+ binding site [ion binding]; other site
399726000170	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726000171	Zn2+ binding site [ion binding]; other site
399726000172	Mg2+ binding site [ion binding]; other site
399726000173	Histidinol phosphatase and related phosphatases [Amino acid transport and metabolism]; Region: HisB; COG0241
399726000174	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
399726000175	CPxP  motif; other site
399726000176	Transcriptional regulator [Transcription]; Region: LysR; COG0583
399726000177	Helix-turn-helix domains; Region: HTH; cl00088
399726000178	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726000179	dimerization interface [polypeptide binding]; other site
399726000180	Sulphur transport; Region: Sulf_transp; cl01018
399726000181	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
399726000182	CPxP  motif; other site
399726000183	putative inner membrane protein; Provisional; Region: PRK11099
399726000184	Sulphur transport; Region: Sulf_transp; cl01018
399726000185	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
399726000186	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000187	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
399726000188	catalytic site [active]
399726000189	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726000190	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
399726000191	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726000192	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
399726000193	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
399726000194	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
399726000195	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
399726000196	homodimer interface [polypeptide binding]; other site
399726000197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726000198	catalytic residue [active]
399726000199	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
399726000200	thymidylate kinase; Validated; Region: tmk; PRK00698
399726000201	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
399726000202	TMP-binding site; other site
399726000203	ATP-binding site [chemical binding]; other site
399726000204	Nitrogen regulatory protein P-II; Region: P-II; cl00412
399726000205	Protein of unknown function (DUF327); Region: DUF327; cl00753
399726000206	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
399726000207	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726000208	PSP1 C-terminal conserved region; Region: PSP1; cl00770
399726000209	Amidinotransferase; Region: Amidinotransf; cl12043
399726000210	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
399726000211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726000212	S-adenosylmethionine binding site [chemical binding]; other site
399726000213	Predicted methyltransferases [General function prediction only]; Region: COG0313
399726000214	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
399726000215	Uncharacterized protein family (UPF0181); Region: UPF0181; cl11477
399726000216	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
399726000217	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
399726000218	Nucleoside recognition; Region: Gate; cl00486
399726000219	Nucleoside recognition; Region: Gate; cl00486
399726000220	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
399726000221	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
399726000222	active site
399726000223	NTP binding site [chemical binding]; other site
399726000224	metal binding triad [ion binding]; metal-binding site
399726000225	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
399726000226	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
399726000227	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
399726000228	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
399726000229	active site
399726000230	HIGH motif; other site
399726000231	KMSKS motif; other site
399726000232	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
399726000233	tRNA binding surface [nucleotide binding]; other site
399726000234	anticodon binding site; other site
399726000235	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
399726000236	dimer interface [polypeptide binding]; other site
399726000237	putative tRNA-binding site [nucleotide binding]; other site
399726000238	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
399726000239	active site
399726000240	Domain of unknown function (DUF348); Region: DUF348; pfam03990
399726000241	Domain of unknown function (DUF348); Region: DUF348; pfam03990
399726000242	G5 domain; Region: G5; pfam07501
399726000243	3D domain; Region: 3D; cl01439
399726000244	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000245	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206
399726000246	PrcB C-terminal; Region: PrcB_C; pfam14343
399726000247	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
399726000248	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
399726000249	Domain of unknown function DUF59; Region: DUF59; cl00941
399726000250	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
399726000251	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
399726000252	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726000253	Walker A motif; other site
399726000254	ATP binding site [chemical binding]; other site
399726000255	Walker B motif; other site
399726000256	arginine finger; other site
399726000257	Peptidase family M41; Region: Peptidase_M41; pfam01434
399726000258	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
399726000259	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
399726000260	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
399726000261	SLBB domain; Region: SLBB; pfam10531
399726000262	4Fe-4S binding domain; Region: Fer4; cl02805
399726000263	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
399726000264	FMN-binding domain; Region: FMN_bind; cl01081
399726000265	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
399726000266	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
399726000267	ferredoxin; Validated; Region: PRK07118
399726000268	Putative Fe-S cluster; Region: FeS; pfam04060
399726000269	4Fe-4S binding domain; Region: Fer4; cl02805
399726000270	4Fe-4S binding domain; Region: Fer4; cl02805
399726000271	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
399726000272	trimer interface [polypeptide binding]; other site
399726000273	Response regulator receiver domain; Region: Response_reg; pfam00072
399726000274	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726000275	active site
399726000276	phosphorylation site [posttranslational modification]
399726000277	intermolecular recognition site; other site
399726000278	dimerization interface [polypeptide binding]; other site
399726000279	hypothetical protein; Provisional; Region: PRK08185
399726000280	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
399726000281	intersubunit interface [polypeptide binding]; other site
399726000282	active site
399726000283	zinc binding site [ion binding]; other site
399726000284	Na+ binding site [ion binding]; other site
399726000285	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
399726000286	transcription termination factor Rho; Provisional; Region: rho; PRK09376
399726000287	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
399726000288	RNA binding site [nucleotide binding]; other site
399726000289	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
399726000290	multimer interface [polypeptide binding]; other site
399726000291	Walker A motif; other site
399726000292	ATP binding site [chemical binding]; other site
399726000293	Walker B motif; other site
399726000294	Ribosomal protein L31; Region: Ribosomal_L31; cl00377
399726000295	thymidine kinase; Provisional; Region: PRK04296
399726000296	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726000297	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
399726000298	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
399726000299	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726000300	S-adenosylmethionine binding site [chemical binding]; other site
399726000301	peptide chain release factor 1; Validated; Region: prfA; PRK00591
399726000302	RF-1 domain; Region: RF-1; cl02875
399726000303	RF-1 domain; Region: RF-1; cl02875
399726000304	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
399726000305	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
399726000306	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
399726000307	Low molecular weight phosphatase family; Region: LMWPc; cd00115
399726000308	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
399726000309	active site
399726000310	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
399726000311	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726000312	active site
399726000313	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
399726000314	catalytic motif [active]
399726000315	Zn binding site [ion binding]; other site
399726000316	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
399726000317	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
399726000318	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
399726000319	hinge; other site
399726000320	active site
399726000321	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
399726000322	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379
399726000323	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000324	NAD(P) binding pocket [chemical binding]; other site
399726000325	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
399726000326	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
399726000327	stage II sporulation protein D; Region: spore_II_D; TIGR02870
399726000328	Stage II sporulation protein; Region: SpoIID; pfam08486
399726000329	Peptidase family M23; Region: Peptidase_M23; pfam01551
399726000330	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726000331	rod shape-determining protein Mbl; Provisional; Region: PRK13928
399726000332	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
399726000333	ATP binding site [chemical binding]; other site
399726000334	profilin binding site; other site
399726000335	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818
399726000336	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
399726000337	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
399726000338	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
399726000339	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
399726000340	flagellar rod assembly protein/muramidase FlgJ; Region: flagell_FlgJ; TIGR02541
399726000341	Rod binding protein; Region: Rod-binding; cl01626
399726000342	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
399726000343	integral membrane protein MviN; Region: mviN; TIGR01695
399726000344	MatE; Region: MatE; cl10513
399726000345	MatE; Region: MatE; cl10513
399726000346	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
399726000347	Uncharacterized conserved protein [Function unknown]; Region: COG2006
399726000348	4Fe-4S binding domain; Region: Fer4; cl02805
399726000349	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
399726000350	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
399726000351	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
399726000352	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
399726000353	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
399726000354	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
399726000355	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726000356	Walker A motif; other site
399726000357	ATP binding site [chemical binding]; other site
399726000358	Walker B motif; other site
399726000359	arginine finger; other site
399726000360	PRD domain; Region: PRD; cl15445
399726000361	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
399726000362	active pocket/dimerization site; other site
399726000363	active site
399726000364	phosphorylation site [posttranslational modification]
399726000365	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
399726000366	active site
399726000367	phosphorylation site [posttranslational modification]
399726000368	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
399726000369	active site
399726000370	phosphorylation site [posttranslational modification]
399726000371	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
399726000372	P-loop; other site
399726000373	active site
399726000374	phosphorylation site [posttranslational modification]
399726000375	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
399726000376	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
399726000377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000378	SAF domain; Region: SAF; cl00555
399726000379	Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721
399726000380	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
399726000381	galactonate dehydratase; Provisional; Region: PRK14017
399726000382	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
399726000383	putative active site pocket [active]
399726000384	putative metal binding site [ion binding]; other site
399726000385	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
399726000386	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000387	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
399726000388	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
399726000389	active site
399726000390	intersubunit interface [polypeptide binding]; other site
399726000391	catalytic residue [active]
399726000392	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
399726000393	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726000394	putative substrate translocation pore; other site
399726000395	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
399726000396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726000397	Walker A motif; other site
399726000398	ATP binding site [chemical binding]; other site
399726000399	Walker B motif; other site
399726000400	arginine finger; other site
399726000401	Transcriptional antiterminator [Transcription]; Region: COG3933
399726000402	PRD domain; Region: PRD; cl15445
399726000403	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
399726000404	active pocket/dimerization site; other site
399726000405	active site
399726000406	phosphorylation site [posttranslational modification]
399726000407	PRD domain; Region: PRD; cl15445
399726000408	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
399726000409	active pocket/dimerization site; other site
399726000410	active site
399726000411	phosphorylation site [posttranslational modification]
399726000412	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
399726000413	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507
399726000414	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
399726000415	active site
399726000416	phosphorylation site [posttranslational modification]
399726000417	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
399726000418	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000419	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
399726000420	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
399726000421	active site
399726000422	intersubunit interface [polypeptide binding]; other site
399726000423	catalytic residue [active]
399726000424	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
399726000425	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000426	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000427	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
399726000428	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
399726000429	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
399726000430	Cation transport protein; Region: TrkH; cl10514
399726000431	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
399726000432	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000433	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
399726000434	Protein of unknown function DUF91; Region: DUF91; cl00709
399726000435	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
399726000436	putative FMN binding site [chemical binding]; other site
399726000437	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
399726000438	iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551
399726000439	active site
399726000440	metal binding site [ion binding]; metal-binding site
399726000441	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
399726000442	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
399726000443	active site
399726000444	FMN binding site [chemical binding]; other site
399726000445	substrate binding site [chemical binding]; other site
399726000446	putative catalytic residue [active]
399726000447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000448	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000449	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726000450	Transcriptional regulator [Transcription]; Region: LysR; COG0583
399726000451	Helix-turn-helix domains; Region: HTH; cl00088
399726000452	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726000453	dimerization interface [polypeptide binding]; other site
399726000454	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726000455	L-rhamnose isomerase (RhaA); Region: RhaA; cl09945
399726000456	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
399726000457	N- and C-terminal domain interface [polypeptide binding]; other site
399726000458	D-xylulose kinase; Region: XylB; TIGR01312
399726000459	active site
399726000460	catalytic site [active]
399726000461	metal binding site [ion binding]; metal-binding site
399726000462	xylulose binding site [chemical binding]; other site
399726000463	putative ATP binding site [chemical binding]; other site
399726000464	homodimer interface [polypeptide binding]; other site
399726000465	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
399726000466	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
399726000467	putative ligand binding site [chemical binding]; other site
399726000468	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
399726000469	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726000470	putative active site [active]
399726000471	putative NTP binding site [chemical binding]; other site
399726000472	putative nucleic acid binding site [nucleotide binding]; other site
399726000473	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
399726000474	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
399726000475	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
399726000476	Walker A/P-loop; other site
399726000477	ATP binding site [chemical binding]; other site
399726000478	Q-loop/lid; other site
399726000479	ABC transporter signature motif; other site
399726000480	Walker B; other site
399726000481	D-loop; other site
399726000482	H-loop/switch region; other site
399726000483	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
399726000484	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
399726000485	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
399726000486	TM-ABC transporter signature motif; other site
399726000487	Helix-turn-helix domains; Region: HTH; cl00088
399726000488	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
399726000489	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726000490	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726000491	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
399726000492	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000493	Transcriptional regulators [Transcription]; Region: PurR; COG1609
399726000494	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726000495	DNA binding site [nucleotide binding]
399726000496	domain linker motif; other site
399726000497	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
399726000498	dimerization interface [polypeptide binding]; other site
399726000499	ligand binding site [chemical binding]; other site
399726000500	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
399726000501	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
399726000502	substrate binding site [chemical binding]; other site
399726000503	dimer interface [polypeptide binding]; other site
399726000504	ATP binding site [chemical binding]; other site
399726000505	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
399726000506	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
399726000507	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
399726000508	Walker A/P-loop; other site
399726000509	ATP binding site [chemical binding]; other site
399726000510	Q-loop/lid; other site
399726000511	ABC transporter signature motif; other site
399726000512	Walker B; other site
399726000513	D-loop; other site
399726000514	H-loop/switch region; other site
399726000515	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
399726000516	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
399726000517	TM-ABC transporter signature motif; other site
399726000518	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
399726000519	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
399726000520	ligand binding site [chemical binding]; other site
399726000521	dimerization interface [polypeptide binding]; other site
399726000522	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
399726000523	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726000524	putative active site [active]
399726000525	putative NTP binding site [chemical binding]; other site
399726000526	putative nucleic acid binding site [nucleotide binding]; other site
399726000527	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
399726000528	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
399726000529	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
399726000530	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
399726000531	putative active site [active]
399726000532	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
399726000533	HPr interaction site; other site
399726000534	glycerol kinase (GK) interaction site [polypeptide binding]; other site
399726000535	active site
399726000536	phosphorylation site [posttranslational modification]
399726000537	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
399726000538	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
399726000539	active site turn [active]
399726000540	phosphorylation site [posttranslational modification]
399726000541	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
399726000542	Bacterial protein of unknown function (DUF871); Region: DUF871; cl15404
399726000543	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
399726000544	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
399726000545	putative active site [active]
399726000546	Helix-turn-helix domains; Region: HTH; cl00088
399726000547	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
399726000548	PRD domain; Region: PRD; cl15445
399726000549	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
399726000550	Protein of unknown function; Region: YhfT; pfam10797
399726000551	Amidase; Region: Amidase; cl11426
399726000552	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
399726000553	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
399726000554	active site
399726000555	substrate binding pocket [chemical binding]; other site
399726000556	homodimer interaction site [polypeptide binding]; other site
399726000557	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
399726000558	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726000559	catalytic residue [active]
399726000560	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
399726000561	dimer interface [polypeptide binding]; other site
399726000562	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
399726000563	active site
399726000564	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
399726000565	substrate binding site [chemical binding]; other site
399726000566	catalytic residue [active]
399726000567	putative mutase; Provisional; Region: PRK12383
399726000568	Sulfatase; Region: Sulfatase; cl10460
399726000569	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
399726000570	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
399726000571	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
399726000572	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
399726000573	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
399726000574	Coenzyme A binding pocket [chemical binding]; other site
399726000575	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
399726000576	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
399726000577	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
399726000578	active site
399726000579	dimer interface [polypeptide binding]; other site
399726000580	hypothetical protein; Validated; Region: PRK07682
399726000581	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
399726000582	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726000583	homodimer interface [polypeptide binding]; other site
399726000584	catalytic residue [active]
399726000585	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
399726000586	Helix-turn-helix domains; Region: HTH; cl00088
399726000587	FeoA domain; Region: FeoA; cl00838
399726000588	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
399726000589	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
399726000590	G1 box; other site
399726000591	GTP/Mg2+ binding site [chemical binding]; other site
399726000592	Switch I region; other site
399726000593	G2 box; other site
399726000594	G3 box; other site
399726000595	Switch II region; other site
399726000596	G4 box; other site
399726000597	G5 box; other site
399726000598	Nucleoside recognition; Region: Gate; cl00486
399726000599	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
399726000600	Nucleoside recognition; Region: Gate; cl00486
399726000601	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
399726000602	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726000603	Walker A/P-loop; other site
399726000604	ATP binding site [chemical binding]; other site
399726000605	Q-loop/lid; other site
399726000606	ABC transporter signature motif; other site
399726000607	Walker B; other site
399726000608	D-loop; other site
399726000609	H-loop/switch region; other site
399726000610	Cobalt transport protein; Region: CbiQ; cl00463
399726000611	PDGLE domain; Region: PDGLE; cl07986
399726000612	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
399726000613	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
399726000614	nickel responsive regulator; Provisional; Region: PRK04460
399726000615	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
399726000616	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
399726000617	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
399726000618	DNA polymerase IV; Provisional; Region: PRK14133
399726000619	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
399726000620	active site
399726000621	DNA binding site [nucleotide binding]
399726000622	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726000623	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726000624	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
399726000625	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
399726000626	E3 interaction surface; other site
399726000627	lipoyl attachment site [posttranslational modification]; other site
399726000628	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
399726000629	carboxyltransferase (CT) interaction site; other site
399726000630	biotinylation site [posttranslational modification]; other site
399726000631	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
399726000632	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
399726000633	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
399726000634	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
399726000635	Walker A/P-loop; other site
399726000636	ATP binding site [chemical binding]; other site
399726000637	Q-loop/lid; other site
399726000638	ABC transporter signature motif; other site
399726000639	Walker B; other site
399726000640	D-loop; other site
399726000641	H-loop/switch region; other site
399726000642	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
399726000643	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
399726000644	FtsX-like permease family; Region: FtsX; cl15850
399726000645	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
399726000646	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
399726000647	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
399726000648	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
399726000649	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726000650	Family description; Region: UvrD_C_2; cl15862
399726000651	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
399726000652	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
399726000653	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
399726000654	active site
399726000655	metal binding site [ion binding]; metal-binding site
399726000656	DNA binding site [nucleotide binding]
399726000657	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
399726000658	SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279
399726000659	AAA domain; Region: AAA_23; pfam13476
399726000660	Walker A/P-loop; other site
399726000661	ATP binding site [chemical binding]; other site
399726000662	Q-loop/lid; other site
399726000663	ABC transporter signature motif; other site
399726000664	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
399726000665	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726000666	Q-loop/lid; other site
399726000667	ABC transporter signature motif; other site
399726000668	Walker B; other site
399726000669	D-loop; other site
399726000670	H-loop/switch region; other site
399726000671	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
399726000672	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
399726000673	tetramer interface [polypeptide binding]; other site
399726000674	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726000675	catalytic residue [active]
399726000676	putative peroxiredoxin; Provisional; Region: PRK13599
399726000677	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
399726000678	dimer interface [polypeptide binding]; other site
399726000679	decamer (pentamer of dimers) interface [polypeptide binding]; other site
399726000680	catalytic triad [active]
399726000681	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
399726000682	metal binding site 2 [ion binding]; metal-binding site
399726000683	putative DNA binding helix; other site
399726000684	metal binding site 1 [ion binding]; metal-binding site
399726000685	dimer interface [polypeptide binding]; other site
399726000686	structural Zn2+ binding site [ion binding]; other site
399726000687	Helix-turn-helix domains; Region: HTH; cl00088
399726000688	ADP-glucose phosphorylase; Region: PLN02643
399726000689	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
399726000690	dimer interface [polypeptide binding]; other site
399726000691	active site
399726000692	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286
399726000693	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
399726000694	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
399726000695	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
399726000696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
399726000697	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
399726000698	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
399726000699	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
399726000700	NAD binding site [chemical binding]; other site
399726000701	dimer interface [polypeptide binding]; other site
399726000702	substrate binding site [chemical binding]; other site
399726000703	tetramer (dimer of dimers) interface [polypeptide binding]; other site
399726000704	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
399726000705	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
399726000706	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000707	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
399726000708	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000709	Domain of unknown function (DUF296); Region: DUF296; cl00720
399726000710	Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862
399726000711	Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862
399726000712	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
399726000713	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
399726000714	ligand binding site [chemical binding]; other site
399726000715	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
399726000716	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726000717	dimerization interface [polypeptide binding]; other site
399726000718	Histidine kinase; Region: His_kinase; pfam06580
399726000719	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726000720	ATP binding site [chemical binding]; other site
399726000721	Mg2+ binding site [ion binding]; other site
399726000722	G-X-G motif; other site
399726000723	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
399726000724	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726000725	active site
399726000726	phosphorylation site [posttranslational modification]
399726000727	intermolecular recognition site; other site
399726000728	dimerization interface [polypeptide binding]; other site
399726000729	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
399726000730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
399726000731	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
399726000732	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
399726000733	putative ligand binding site [chemical binding]; other site
399726000734	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
399726000735	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
399726000736	putative ligand binding site [chemical binding]; other site
399726000737	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
399726000738	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
399726000739	Walker A/P-loop; other site
399726000740	ATP binding site [chemical binding]; other site
399726000741	Q-loop/lid; other site
399726000742	ABC transporter signature motif; other site
399726000743	Walker B; other site
399726000744	D-loop; other site
399726000745	H-loop/switch region; other site
399726000746	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
399726000747	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
399726000748	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
399726000749	TM-ABC transporter signature motif; other site
399726000750	Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003
399726000751	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
399726000752	tetramer interface [polypeptide binding]; other site
399726000753	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726000754	catalytic residue [active]
399726000755	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
399726000756	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
399726000757	tetramer interface [polypeptide binding]; other site
399726000758	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726000759	catalytic residue [active]
399726000760	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
399726000761	lipoyl attachment site [posttranslational modification]; other site
399726000762	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
399726000763	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
399726000764	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
399726000765	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
399726000766	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
399726000767	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
399726000768	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
399726000769	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
399726000770	E3 interaction surface; other site
399726000771	lipoyl attachment site [posttranslational modification]; other site
399726000772	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
399726000773	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726000774	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
399726000775	OsmC-like protein; Region: OsmC; cl00767
399726000776	hypothetical protein; Validated; Region: PRK07682
399726000777	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
399726000778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726000779	homodimer interface [polypeptide binding]; other site
399726000780	catalytic residue [active]
399726000781	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
399726000782	Helix-turn-helix domains; Region: HTH; cl00088
399726000783	Helix-turn-helix domains; Region: HTH; cl00088
399726000784	PRD domain; Region: PRD; cl15445
399726000785	PRD domain; Region: PRD; cl15445
399726000786	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
399726000787	P-loop; other site
399726000788	active site
399726000789	phosphorylation site [posttranslational modification]
399726000790	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
399726000791	active site
399726000792	phosphorylation site [posttranslational modification]
399726000793	PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451
399726000794	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
399726000795	P-loop; other site
399726000796	active site
399726000797	phosphorylation site [posttranslational modification]
399726000798	hypothetical protein; Provisional; Region: PRK02947
399726000799	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
399726000800	putative active site [active]
399726000801	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
399726000802	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
399726000803	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
399726000804	dimer interface [polypeptide binding]; other site
399726000805	active site
399726000806	metal binding site [ion binding]; metal-binding site
399726000807	Transglycosylase; Region: Transgly; cl07896
399726000808	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
399726000809	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726000810	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
399726000811	structural tetrad; other site
399726000812	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
399726000813	metal binding site [ion binding]; metal-binding site
399726000814	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
399726000815	dimerization interface [polypeptide binding]; other site
399726000816	putative DNA binding site [nucleotide binding]; other site
399726000817	putative Zn2+ binding site [ion binding]; other site
399726000818	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
399726000819	4Fe-4S binding domain; Region: Fer4; cl02805
399726000820	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
399726000821	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
399726000822	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
399726000823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
399726000824	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
399726000825	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726000826	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250
399726000827	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
399726000828	Walker A/P-loop; other site
399726000829	ATP binding site [chemical binding]; other site
399726000830	Q-loop/lid; other site
399726000831	ABC transporter signature motif; other site
399726000832	Walker B; other site
399726000833	D-loop; other site
399726000834	H-loop/switch region; other site
399726000835	Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424
399726000836	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
399726000837	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
399726000838	HIGH motif; other site
399726000839	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
399726000840	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
399726000841	active site
399726000842	KMSKS motif; other site
399726000843	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
399726000844	tRNA binding surface [nucleotide binding]; other site
399726000845	AzlC protein; Region: AzlC; cl00570
399726000846	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
399726000847	putative kinase; Provisional; Region: PRK09954
399726000848	Helix-turn-helix domains; Region: HTH; cl00088
399726000849	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
399726000850	substrate binding site [chemical binding]; other site
399726000851	ATP binding site [chemical binding]; other site
399726000852	Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983
399726000853	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951
399726000854	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
399726000855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726000856	Walker B motif; other site
399726000857	arginine finger; other site
399726000858	PRD domain; Region: PRD; cl15445
399726000859	Transcriptional antiterminator [Transcription]; Region: COG3933
399726000860	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
399726000861	active pocket/dimerization site; other site
399726000862	active site
399726000863	phosphorylation site [posttranslational modification]
399726000864	PRD domain; Region: PRD; cl15445
399726000865	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
399726000866	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
399726000867	YdjC-like protein; Region: YdjC; cl01344
399726000868	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
399726000869	active site
399726000870	P-loop; other site
399726000871	phosphorylation site [posttranslational modification]
399726000872	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
399726000873	methionine cluster; other site
399726000874	active site
399726000875	phosphorylation site [posttranslational modification]
399726000876	metal binding site [ion binding]; metal-binding site
399726000877	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
399726000878	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
399726000879	NAD binding site [chemical binding]; other site
399726000880	sugar binding site [chemical binding]; other site
399726000881	divalent metal binding site [ion binding]; other site
399726000882	tetramer (dimer of dimers) interface [polypeptide binding]; other site
399726000883	dimer interface [polypeptide binding]; other site
399726000884	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
399726000885	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
399726000886	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
399726000887	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
399726000888	active site
399726000889	P-loop; other site
399726000890	phosphorylation site [posttranslational modification]
399726000891	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
399726000892	PRD domain; Region: PRD; cl15445
399726000893	PRD domain; Region: PRD; cl15445
399726000894	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
399726000895	P-loop; other site
399726000896	active site
399726000897	phosphorylation site [posttranslational modification]
399726000898	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
399726000899	active site
399726000900	phosphorylation site [posttranslational modification]
399726000901	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
399726000902	active site
399726000903	phosphorylation site [posttranslational modification]
399726000904	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
399726000905	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
399726000906	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
399726000907	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
399726000908	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
399726000909	active site
399726000910	metal binding site [ion binding]; metal-binding site
399726000911	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
399726000912	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
399726000913	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
399726000914	active site
399726000915	metal binding site [ion binding]; metal-binding site
399726000916	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
399726000917	Bacterial SH3 domain; Region: SH3_3; cl02551
399726000918	Bacterial SH3 domain; Region: SH3_3; cl02551
399726000919	Bacterial SH3 domain; Region: SH3_3; cl02551
399726000920	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
399726000921	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
399726000922	FMN binding site [chemical binding]; other site
399726000923	active site
399726000924	catalytic residues [active]
399726000925	substrate binding site [chemical binding]; other site
399726000926	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
399726000927	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
399726000928	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
399726000929	ABC-ATPase subunit  interface; other site
399726000930	dimer interface [polypeptide binding]; other site
399726000931	putative PBP binding regions; other site
399726000932	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
399726000933	ABC component of the metal-type transporters.  This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc.  The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235
399726000934	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
399726000935	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
399726000936	metal binding site [ion binding]; metal-binding site
399726000937	ferric uptake regulator; Provisional; Region: fur; PRK09462
399726000938	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
399726000939	metal binding site 2 [ion binding]; metal-binding site
399726000940	putative DNA binding helix; other site
399726000941	metal binding site 1 [ion binding]; metal-binding site
399726000942	dimer interface [polypeptide binding]; other site
399726000943	structural Zn2+ binding site [ion binding]; other site
399726000944	MoxR-like ATPases [General function prediction only]; Region: COG0714
399726000945	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726000946	Walker A motif; other site
399726000947	ATP binding site [chemical binding]; other site
399726000948	Walker B motif; other site
399726000949	arginine finger; other site
399726000950	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
399726000951	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
399726000952	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
399726000953	LemA family; Region: LemA; cl00742
399726000954	LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180
399726000955	Helix-turn-helix domains; Region: HTH; cl00088
399726000956	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
399726000957	putative dimerization interface [polypeptide binding]; other site
399726000958	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
399726000959	Src homology 2 (SH2) domain; Region: SH2; cl15255
399726000960	phosphotyrosine binding pocket [polypeptide binding]; other site
399726000961	hydrophobic binding pocket [polypeptide binding]; other site
399726000962	anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221
399726000963	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
399726000964	FAD binding pocket [chemical binding]; other site
399726000965	FAD binding motif [chemical binding]; other site
399726000966	phosphate binding motif [ion binding]; other site
399726000967	beta-alpha-beta structure motif; other site
399726000968	NAD binding pocket [chemical binding]; other site
399726000969	Iron coordination center [ion binding]; other site
399726000970	sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912
399726000971	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
399726000972	4Fe-4S binding domain; Region: Fer4; cl02805
399726000973	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
399726000974	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
399726000975	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726000976	catalytic residue [active]
399726000977	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
399726000978	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
399726000979	trimerization site [polypeptide binding]; other site
399726000980	active site
399726000981	Repair protein; Region: Repair_PSII; cl01535
399726000982	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
399726000983	putative active site [active]
399726000984	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
399726000985	THUMP domain; Region: THUMP; cl12076
399726000986	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726000987	PemK-like protein; Region: PemK; cl00995
399726000988	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
399726000989	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
399726000990	putative binding site residues; other site
399726000991	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
399726000992	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
399726000993	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
399726000994	ABC-ATPase subunit  interface; other site
399726000995	dimer interface [polypeptide binding]; other site
399726000996	putative PBP binding regions; other site
399726000997	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
399726000998	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
399726000999	Walker A/P-loop; other site
399726001000	ATP binding site [chemical binding]; other site
399726001001	Q-loop/lid; other site
399726001002	ABC transporter signature motif; other site
399726001003	Walker B; other site
399726001004	D-loop; other site
399726001005	H-loop/switch region; other site
399726001006	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
399726001007	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001008	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
399726001009	catalytic triad [active]
399726001010	cobyric acid synthase; Provisional; Region: PRK00784
399726001011	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001012	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001013	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
399726001014	catalytic triad [active]
399726001015	CobD/Cbib protein; Region: CobD_Cbib; cl00561
399726001016	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
399726001017	AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586
399726001018	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
399726001019	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
399726001020	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726001021	homodimer interface [polypeptide binding]; other site
399726001022	catalytic residue [active]
399726001023	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
399726001024	homotrimer interface [polypeptide binding]; other site
399726001025	Walker A motif; other site
399726001026	GTP binding site [chemical binding]; other site
399726001027	Walker B motif; other site
399726001028	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
399726001029	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
399726001030	putative active site [active]
399726001031	Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913
399726001032	Precorrin-8X methylmutase; Region: CbiC; pfam02570
399726001033	CbiD; Region: CbiD; cl00828
399726001034	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
399726001035	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
399726001036	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
399726001037	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
399726001038	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
399726001039	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
399726001040	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
399726001041	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
399726001042	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
399726001043	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
399726001044	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
399726001045	Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133
399726001046	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
399726001047	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
399726001048	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
399726001049	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; cl00922
399726001050	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
399726001051	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
399726001052	tRNA; other site
399726001053	putative tRNA binding site [nucleotide binding]; other site
399726001054	putative NADP binding site [chemical binding]; other site
399726001055	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
399726001056	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
399726001057	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189
399726001058	domain interfaces; other site
399726001059	active site
399726001060	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
399726001061	Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; pfam00590
399726001062	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
399726001063	active site
399726001064	Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602
399726001065	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
399726001066	dimer interface [polypeptide binding]; other site
399726001067	active site
399726001068	Schiff base residues; other site
399726001069	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
399726001070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001071	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
399726001072	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
399726001073	inhibitor-cofactor binding pocket; inhibition site
399726001074	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726001075	catalytic residue [active]
399726001076	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397
399726001077	Cobalt transport protein component CbiN; Region: CbiN; cl00842
399726001078	Cobalt transport protein; Region: CbiQ; cl00463
399726001079	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636
399726001080	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726001081	Walker A/P-loop; other site
399726001082	ATP binding site [chemical binding]; other site
399726001083	Q-loop/lid; other site
399726001084	ABC transporter signature motif; other site
399726001085	Walker B; other site
399726001086	D-loop; other site
399726001087	H-loop/switch region; other site
399726001088	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
399726001089	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
399726001090	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726001091	Walker A/P-loop; other site
399726001092	ATP binding site [chemical binding]; other site
399726001093	Q-loop/lid; other site
399726001094	ABC transporter signature motif; other site
399726001095	Walker B; other site
399726001096	D-loop; other site
399726001097	H-loop/switch region; other site
399726001098	Rhomboid family; Region: Rhomboid; cl11446
399726001099	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
399726001100	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
399726001101	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
399726001102	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
399726001103	Coenzyme A binding pocket [chemical binding]; other site
399726001104	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
399726001105	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001106	Walker A/P-loop; other site
399726001107	ATP binding site [chemical binding]; other site
399726001108	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
399726001109	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001110	Walker A/P-loop; other site
399726001111	ATP binding site [chemical binding]; other site
399726001112	Q-loop/lid; other site
399726001113	ABC transporter signature motif; other site
399726001114	Walker B; other site
399726001115	D-loop; other site
399726001116	H-loop/switch region; other site
399726001117	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
399726001118	ABC-2 type transporter; Region: ABC2_membrane; cl11417
399726001119	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
399726001120	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
399726001121	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
399726001122	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
399726001123	Walker A/P-loop; other site
399726001124	ATP binding site [chemical binding]; other site
399726001125	Q-loop/lid; other site
399726001126	ABC transporter signature motif; other site
399726001127	Walker B; other site
399726001128	D-loop; other site
399726001129	H-loop/switch region; other site
399726001130	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
399726001131	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
399726001132	DNA binding residues [nucleotide binding]
399726001133	dimerization interface [polypeptide binding]; other site
399726001134	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
399726001135	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726001136	FeS/SAM binding site; other site
399726001137	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
399726001138	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
399726001139	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001140	Walker A/P-loop; other site
399726001141	ATP binding site [chemical binding]; other site
399726001142	Q-loop/lid; other site
399726001143	ABC transporter signature motif; other site
399726001144	Walker B; other site
399726001145	D-loop; other site
399726001146	H-loop/switch region; other site
399726001147	ABC-2 type transporter; Region: ABC2_membrane; cl11417
399726001148	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
399726001149	CAAX protease self-immunity; Region: Abi; cl00558
399726001150	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
399726001151	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726001152	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001153	Walker A/P-loop; other site
399726001154	ATP binding site [chemical binding]; other site
399726001155	Q-loop/lid; other site
399726001156	ABC transporter signature motif; other site
399726001157	Walker B; other site
399726001158	D-loop; other site
399726001159	H-loop/switch region; other site
399726001160	Transposase, Mutator family; Region: Transposase_mut; pfam00872
399726001161	MULE transposase domain; Region: MULE; pfam10551
399726001162	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001163	Walker A/P-loop; other site
399726001164	ATP binding site [chemical binding]; other site
399726001165	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
399726001166	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001167	Walker A/P-loop; other site
399726001168	ATP binding site [chemical binding]; other site
399726001169	Q-loop/lid; other site
399726001170	ABC transporter signature motif; other site
399726001171	Walker B; other site
399726001172	D-loop; other site
399726001173	H-loop/switch region; other site
399726001174	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
399726001175	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
399726001176	ABC-2 type transporter; Region: ABC2_membrane; cl11417
399726001177	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
399726001178	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
399726001179	Membrane transport protein; Region: Mem_trans; cl09117
399726001180	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
399726001181	Ycf48-like protein; Provisional; Region: PRK13684
399726001182	Ycf48-like protein; Provisional; Region: PRK13684
399726001183	Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447
399726001184	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
399726001185	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
399726001186	Walker A/P-loop; other site
399726001187	ATP binding site [chemical binding]; other site
399726001188	Q-loop/lid; other site
399726001189	ABC transporter signature motif; other site
399726001190	Walker B; other site
399726001191	D-loop; other site
399726001192	H-loop/switch region; other site
399726001193	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
399726001194	DNA-binding site [nucleotide binding]; DNA binding site
399726001195	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
399726001196	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
399726001197	oligomer interface [polypeptide binding]; other site
399726001198	active site
399726001199	metal binding site [ion binding]; metal-binding site
399726001200	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
399726001201	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
399726001202	oligomer interface [polypeptide binding]; other site
399726001203	active site
399726001204	metal binding site [ion binding]; metal-binding site
399726001205	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
399726001206	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
399726001207	oligomer interface [polypeptide binding]; other site
399726001208	active site
399726001209	metal binding site [ion binding]; metal-binding site
399726001210	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
399726001211	diiron binding motif [ion binding]; other site
399726001212	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
399726001213	Helix-turn-helix domains; Region: HTH; cl00088
399726001214	Integrase core domain; Region: rve; cl01316
399726001215	Integrase core domain; Region: rve_3; cl15866
399726001216	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
399726001217	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
399726001218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726001219	Walker A motif; other site
399726001220	ATP binding site [chemical binding]; other site
399726001221	Walker B motif; other site
399726001222	arginine finger; other site
399726001223	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
399726001224	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726001225	putative active site [active]
399726001226	putative NTP binding site [chemical binding]; other site
399726001227	putative nucleic acid binding site [nucleotide binding]; other site
399726001228	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
399726001229	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
399726001230	dimer interface [polypeptide binding]; other site
399726001231	PYR/PP interface [polypeptide binding]; other site
399726001232	TPP binding site [chemical binding]; other site
399726001233	substrate binding site [chemical binding]; other site
399726001234	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
399726001235	Domain of unknown function; Region: EKR; cl11037
399726001236	4Fe-4S binding domain; Region: Fer4; cl02805
399726001237	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
399726001238	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
399726001239	TPP-binding site [chemical binding]; other site
399726001240	dimer interface [polypeptide binding]; other site
399726001241	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726001242	Zn2+ binding site [ion binding]; other site
399726001243	Mg2+ binding site [ion binding]; other site
399726001244	Cache domain; Region: Cache_2; cl07034
399726001245	Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850
399726001246	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726001247	dimerization interface [polypeptide binding]; other site
399726001248	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
399726001249	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
399726001250	dimer interface [polypeptide binding]; other site
399726001251	putative CheW interface [polypeptide binding]; other site
399726001252	glutamate formiminotransferase; Region: FtcD; TIGR02024
399726001253	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
399726001254	Formiminotransferase domain; Region: FTCD; pfam02971
399726001255	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
399726001256	Protein of unknown function DUF86; Region: DUF86; cl01031
399726001257	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
399726001258	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
399726001259	NAD binding site [chemical binding]; other site
399726001260	sugar binding site [chemical binding]; other site
399726001261	divalent metal binding site [ion binding]; other site
399726001262	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
399726001263	dimer interface [polypeptide binding]; other site
399726001264	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
399726001265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726001266	dimer interface [polypeptide binding]; other site
399726001267	conserved gate region; other site
399726001268	putative PBP binding loops; other site
399726001269	ABC-ATPase subunit interface; other site
399726001270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726001271	dimer interface [polypeptide binding]; other site
399726001272	conserved gate region; other site
399726001273	putative PBP binding loops; other site
399726001274	ABC-ATPase subunit interface; other site
399726001275	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
399726001276	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726001277	Cache domain; Region: Cache_1; pfam02743
399726001278	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726001279	dimerization interface [polypeptide binding]; other site
399726001280	Histidine kinase; Region: His_kinase; pfam06580
399726001281	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726001282	Mg2+ binding site [ion binding]; other site
399726001283	G-X-G motif; other site
399726001284	Response regulator receiver domain; Region: Response_reg; pfam00072
399726001285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726001286	active site
399726001287	phosphorylation site [posttranslational modification]
399726001288	intermolecular recognition site; other site
399726001289	dimerization interface [polypeptide binding]; other site
399726001290	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
399726001291	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
399726001292	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
399726001293	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
399726001294	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
399726001295	ligand binding site [chemical binding]; other site
399726001296	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
399726001297	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
399726001298	Walker A/P-loop; other site
399726001299	ATP binding site [chemical binding]; other site
399726001300	Q-loop/lid; other site
399726001301	ABC transporter signature motif; other site
399726001302	Walker B; other site
399726001303	D-loop; other site
399726001304	H-loop/switch region; other site
399726001305	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
399726001306	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
399726001307	TM-ABC transporter signature motif; other site
399726001308	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
399726001309	TM-ABC transporter signature motif; other site
399726001310	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
399726001311	active site
399726001312	catalytic motif [active]
399726001313	Zn binding site [ion binding]; other site
399726001314	Sulfatase; Region: Sulfatase; cl10460
399726001315	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
399726001316	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
399726001317	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
399726001318	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
399726001319	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
399726001320	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
399726001321	dimer interface [polypeptide binding]; other site
399726001322	putative CheW interface [polypeptide binding]; other site
399726001323	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
399726001324	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
399726001325	active site turn [active]
399726001326	phosphorylation site [posttranslational modification]
399726001327	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162
399726001328	HPr interaction site; other site
399726001329	glycerol kinase (GK) interaction site [polypeptide binding]; other site
399726001330	active site
399726001331	phosphorylation site [posttranslational modification]
399726001332	CAT RNA binding domain; Region: CAT_RBD; cl03904
399726001333	transcriptional antiterminator BglG; Provisional; Region: PRK09772
399726001334	PRD domain; Region: PRD; cl15445
399726001335	PRD domain; Region: PRD; cl15445
399726001336	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
399726001337	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
399726001338	active site
399726001339	catalytic residues [active]
399726001340	metal binding site [ion binding]; metal-binding site
399726001341	aconitate hydratase; Validated; Region: PRK07229
399726001342	Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585
399726001343	substrate binding site [chemical binding]; other site
399726001344	ligand binding site [chemical binding]; other site
399726001345	Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215
399726001346	substrate binding site [chemical binding]; other site
399726001347	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
399726001348	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
399726001349	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
399726001350	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
399726001351	phosphate binding site [ion binding]; other site
399726001352	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
399726001353	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
399726001354	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
399726001355	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
399726001356	tetramerization interface [polypeptide binding]; other site
399726001357	active site
399726001358	pantoate--beta-alanine ligase; Region: panC; TIGR00018
399726001359	Pantoate-beta-alanine ligase; Region: PanC; cd00560
399726001360	active site
399726001361	ATP-binding site [chemical binding]; other site
399726001362	pantoate-binding site; other site
399726001363	HXXH motif; other site
399726001364	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
399726001365	oligomerization interface [polypeptide binding]; other site
399726001366	active site
399726001367	metal binding site [ion binding]; metal-binding site
399726001368	Uncharacterized conserved protein [Function unknown]; Region: COG5495
399726001369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001370	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
399726001371	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
399726001372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001373	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
399726001374	DNA binding site [nucleotide binding]
399726001375	active site
399726001376	Int/Topo IB signature motif; other site
399726001377	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
399726001378	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
399726001379	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726001380	AIR carboxylase; Region: AIRC; cl00310
399726001381	Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890
399726001382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726001383	putative substrate translocation pore; other site
399726001384	Domain of unknown function (DUF4363); Region: DUF4363; pfam14276
399726001385	Protein of unknown function (DUF421); Region: DUF421; cl00990
399726001386	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726001387	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
399726001388	active site
399726001389	motif I; other site
399726001390	motif II; other site
399726001391	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726001392	catabolite control protein A; Region: ccpA; TIGR01481
399726001393	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726001394	DNA binding site [nucleotide binding]
399726001395	domain linker motif; other site
399726001396	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
399726001397	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
399726001398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726001399	active site
399726001400	phosphorylation site [posttranslational modification]
399726001401	intermolecular recognition site; other site
399726001402	dimerization interface [polypeptide binding]; other site
399726001403	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
399726001404	DNA binding site [nucleotide binding]
399726001405	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726001406	dimerization interface [polypeptide binding]; other site
399726001407	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
399726001408	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
399726001409	dimer interface [polypeptide binding]; other site
399726001410	phosphorylation site [posttranslational modification]
399726001411	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726001412	ATP binding site [chemical binding]; other site
399726001413	Mg2+ binding site [ion binding]; other site
399726001414	G-X-G motif; other site
399726001415	Sporulation and spore germination; Region: Germane; cl11253
399726001416	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
399726001417	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
399726001418	Rubrerythrin [Energy production and conversion]; Region: COG1592
399726001419	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
399726001420	binuclear metal center [ion binding]; other site
399726001421	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
399726001422	iron binding site [ion binding]; other site
399726001423	S-adenosylmethionine synthetase; Validated; Region: PRK05250
399726001424	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
399726001425	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
399726001426	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
399726001427	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
399726001428	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001429	Family description; Region: UvrD_C_2; cl15862
399726001430	comF family protein; Region: comF; TIGR00201
399726001431	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726001432	active site
399726001433	flagellar operon protein TIGR03826; Region: YvyF
399726001434	FlgN protein; Region: FlgN; cl09176
399726001435	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
399726001436	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
399726001437	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
399726001438	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
399726001439	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
399726001440	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
399726001441	FliW protein; Region: FliW; cl00740
399726001442	Global regulator protein family; Region: CsrA; cl00670
399726001443	flagellin; Reviewed; Region: PRK08869
399726001444	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
399726001445	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
399726001446	LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161
399726001447	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001448	DpnII restriction endonuclease; Region: DpnII; pfam04556
399726001449	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001450	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001451	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001452	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
399726001453	active site
399726001454	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
399726001455	dimer interface [polypeptide binding]; other site
399726001456	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
399726001457	Ligand Binding Site [chemical binding]; other site
399726001458	Molecular Tunnel; other site
399726001459	FlaG protein; Region: FlaG; cl00591
399726001460	flagellar capping protein; Validated; Region: fliD; PRK07737
399726001461	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
399726001462	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
399726001463	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
399726001464	Flagellar protein FliS; Region: FliS; cl00654
399726001465	FlgN protein; Region: FlgN; cl09176
399726001466	Probable zinc-binding domain; Region: zf-trcl; pfam13451
399726001467	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
399726001468	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
399726001469	substrate binding pocket [chemical binding]; other site
399726001470	membrane-bound complex binding site; other site
399726001471	hinge residues; other site
399726001472	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
399726001473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726001474	dimer interface [polypeptide binding]; other site
399726001475	conserved gate region; other site
399726001476	putative PBP binding loops; other site
399726001477	ABC-ATPase subunit interface; other site
399726001478	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
399726001479	HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively.  Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP.  HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262
399726001480	Walker A/P-loop; other site
399726001481	ATP binding site [chemical binding]; other site
399726001482	Q-loop/lid; other site
399726001483	ABC transporter signature motif; other site
399726001484	Walker B; other site
399726001485	D-loop; other site
399726001486	H-loop/switch region; other site
399726001487	RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552
399726001488	30S subunit binding site; other site
399726001489	Protein of unknown function (DUF1646); Region: DUF1646; pfam07854
399726001490	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
399726001491	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726001492	Zn2+ binding site [ion binding]; other site
399726001493	Mg2+ binding site [ion binding]; other site
399726001494	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
399726001495	Helix-turn-helix domains; Region: HTH; cl00088
399726001496	3H domain; Region: 3H; pfam02829
399726001497	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
399726001498	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001499	SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078
399726001500	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
399726001501	nucleotide binding region [chemical binding]; other site
399726001502	peptide chain release factor 2; Provisional; Region: PRK05589
399726001503	RF-1 domain; Region: RF-1; cl02875
399726001504	RF-1 domain; Region: RF-1; cl02875
399726001505	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
399726001506	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
399726001507	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
399726001508	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
399726001509	RNA binding site [nucleotide binding]; other site
399726001510	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
399726001511	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
399726001512	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
399726001513	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
399726001514	active site
399726001515	Amidinotransferase; Region: Amidinotransf; cl12043
399726001516	ornithine carbamoyltransferase; Validated; Region: PRK02102
399726001517	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
399726001518	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001519	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
399726001520	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
399726001521	putative substrate binding site [chemical binding]; other site
399726001522	nucleotide binding site [chemical binding]; other site
399726001523	nucleotide binding site [chemical binding]; other site
399726001524	homodimer interface [polypeptide binding]; other site
399726001525	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
399726001526	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
399726001527	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726001528	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
399726001529	putative active site [active]
399726001530	putative NTP binding site [chemical binding]; other site
399726001531	putative nucleic acid binding site [nucleotide binding]; other site
399726001532	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
399726001533	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
399726001534	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
399726001535	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
399726001536	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
399726001537	Coenzyme A binding pocket [chemical binding]; other site
399726001538	UGMP family protein; Validated; Region: PRK09604
399726001539	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000
399726001540	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
399726001541	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001542	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
399726001543	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
399726001544	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
399726001545	ABC transporter; Region: ABC_tran_2; pfam12848
399726001546	ABCF_EF-3  Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth.  EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221
399726001547	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
399726001548	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
399726001549	flagellar motor protein MotS; Reviewed; Region: PRK06925
399726001550	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
399726001551	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
399726001552	ligand binding site [chemical binding]; other site
399726001553	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
399726001554	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
399726001555	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726001556	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
399726001557	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726001558	active site
399726001559	phosphorylation site [posttranslational modification]
399726001560	intermolecular recognition site; other site
399726001561	dimerization interface [polypeptide binding]; other site
399726001562	LytTr DNA-binding domain; Region: LytTR; cl04498
399726001563	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
399726001564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726001565	ATP binding site [chemical binding]; other site
399726001566	Mg2+ binding site [ion binding]; other site
399726001567	G-X-G motif; other site
399726001568	Accessory gene regulator B; Region: AgrB; cl01873
399726001569	Asp23 family; Region: Asp23; cl00574
399726001570	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
399726001571	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
399726001572	FAD binding pocket [chemical binding]; other site
399726001573	FAD binding motif [chemical binding]; other site
399726001574	phosphate binding motif [ion binding]; other site
399726001575	beta-alpha-beta structure motif; other site
399726001576	NAD binding pocket [chemical binding]; other site
399726001577	Iron coordination center [ion binding]; other site
399726001578	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
399726001579	phosphate binding site [ion binding]; other site
399726001580	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
399726001581	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
399726001582	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
399726001583	minor groove reading motif; other site
399726001584	helix-hairpin-helix signature motif; other site
399726001585	substrate binding pocket [chemical binding]; other site
399726001586	active site
399726001587	Protein of unknown function (DUF554); Region: DUF554; cl00784
399726001588	HutP; Region: HutP; cl07944
399726001589	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
399726001590	active site
399726001591	catalytic triad [active]
399726001592	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
399726001593	oligomerisation interface [polypeptide binding]; other site
399726001594	mobile loop; other site
399726001595	roof hairpin; other site
399726001596	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
399726001597	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
399726001598	ring oligomerisation interface [polypeptide binding]; other site
399726001599	ATP/Mg binding site [chemical binding]; other site
399726001600	stacking interactions; other site
399726001601	hinge regions; other site
399726001602	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
399726001603	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
399726001604	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601
399726001605	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381
399726001606	active site
399726001607	GMP synthase; Reviewed; Region: guaA; PRK00074
399726001608	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
399726001609	AMP/PPi binding site [chemical binding]; other site
399726001610	candidate oxyanion hole; other site
399726001611	catalytic triad [active]
399726001612	potential glutamine specificity residues [chemical binding]; other site
399726001613	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
399726001614	ATP Binding subdomain [chemical binding]; other site
399726001615	Ligand Binding sites [chemical binding]; other site
399726001616	Dimerization subdomain; other site
399726001617	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
399726001618	AIR carboxylase; Region: AIRC; cl00310
399726001619	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
399726001620	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
399726001621	ATP binding site [chemical binding]; other site
399726001622	active site
399726001623	substrate binding site [chemical binding]; other site
399726001624	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
399726001625	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
399726001626	putative active site [active]
399726001627	catalytic triad [active]
399726001628	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
399726001629	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
399726001630	dimerization interface [polypeptide binding]; other site
399726001631	ATP binding site [chemical binding]; other site
399726001632	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
399726001633	dimerization interface [polypeptide binding]; other site
399726001634	ATP binding site [chemical binding]; other site
399726001635	amidophosphoribosyltransferase; Provisional; Region: PRK05793
399726001636	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
399726001637	active site
399726001638	tetramer interface [polypeptide binding]; other site
399726001639	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726001640	active site
399726001641	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
399726001642	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
399726001643	dimerization interface [polypeptide binding]; other site
399726001644	putative ATP binding site [chemical binding]; other site
399726001645	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
399726001646	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
399726001647	active site
399726001648	substrate binding site [chemical binding]; other site
399726001649	cosubstrate binding site; other site
399726001650	catalytic site [active]
399726001651	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
399726001652	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
399726001653	purine monophosphate binding site [chemical binding]; other site
399726001654	dimer interface [polypeptide binding]; other site
399726001655	putative catalytic residues [active]
399726001656	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
399726001657	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
399726001658	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
399726001659	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
399726001660	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726001661	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
399726001662	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
399726001663	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
399726001664	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
399726001665	metal binding site [ion binding]; metal-binding site
399726001666	dimer interface [polypeptide binding]; other site
399726001667	stage V sporulation protein B; Region: spore_V_B; TIGR02900
399726001668	MatE; Region: MatE; cl10513
399726001669	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
399726001670	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
399726001671	Helix-turn-helix domains; Region: HTH; cl00088
399726001672	Helix-turn-helix domains; Region: HTH; cl00088
399726001673	PRD domain; Region: PRD; cl15445
399726001674	PRD domain; Region: PRD; cl15445
399726001675	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
399726001676	P-loop; other site
399726001677	active site
399726001678	phosphorylation site [posttranslational modification]
399726001679	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
399726001680	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
399726001681	active site
399726001682	P-loop; other site
399726001683	phosphorylation site [posttranslational modification]
399726001684	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
399726001685	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
399726001686	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166
399726001687	methionine cluster; other site
399726001688	active site
399726001689	phosphorylation site [posttranslational modification]
399726001690	metal binding site [ion binding]; metal-binding site
399726001691	Helix-turn-helix domains; Region: HTH; cl00088
399726001692	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
399726001693	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726001694	Family description; Region: UvrD_C_2; cl15862
399726001695	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
399726001696	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
399726001697	nucleotide binding pocket [chemical binding]; other site
399726001698	K-X-D-G motif; other site
399726001699	catalytic site [active]
399726001700	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
399726001701	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
399726001702	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
399726001703	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
399726001704	Dimer interface [polypeptide binding]; other site
399726001705	BRCT sequence motif; other site
399726001706	Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495
399726001707	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
399726001708	Amidase; Region: Amidase; cl11426
399726001709	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
399726001710	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
399726001711	GatB domain; Region: GatB_Yqey; cl11497
399726001712	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
399726001713	Helix-turn-helix domains; Region: HTH; cl00088
399726001714	Integrase core domain; Region: rve; cl01316
399726001715	Integrase core domain; Region: rve_3; cl15866
399726001716	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
399726001717	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
399726001718	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726001719	Walker A motif; other site
399726001720	ATP binding site [chemical binding]; other site
399726001721	Walker B motif; other site
399726001722	arginine finger; other site
399726001723	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
399726001724	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
399726001725	peptide binding site [polypeptide binding]; other site
399726001726	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
399726001727	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726001728	dimer interface [polypeptide binding]; other site
399726001729	conserved gate region; other site
399726001730	putative PBP binding loops; other site
399726001731	ABC-ATPase subunit interface; other site
399726001732	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
399726001733	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
399726001734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726001735	dimer interface [polypeptide binding]; other site
399726001736	conserved gate region; other site
399726001737	putative PBP binding loops; other site
399726001738	ABC-ATPase subunit interface; other site
399726001739	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
399726001740	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
399726001741	Walker A/P-loop; other site
399726001742	ATP binding site [chemical binding]; other site
399726001743	Q-loop/lid; other site
399726001744	ABC transporter signature motif; other site
399726001745	Walker B; other site
399726001746	D-loop; other site
399726001747	H-loop/switch region; other site
399726001748	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
399726001749	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
399726001750	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
399726001751	Walker A/P-loop; other site
399726001752	ATP binding site [chemical binding]; other site
399726001753	Q-loop/lid; other site
399726001754	ABC transporter signature motif; other site
399726001755	Walker B; other site
399726001756	D-loop; other site
399726001757	H-loop/switch region; other site
399726001758	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
399726001759	ribonuclease PH; Reviewed; Region: rph; PRK00173
399726001760	Ribonuclease PH; Region: RNase_PH_bact; cd11362
399726001761	hexamer interface [polypeptide binding]; other site
399726001762	active site
399726001763	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
399726001764	active site
399726001765	dimerization interface [polypeptide binding]; other site
399726001766	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
399726001767	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
399726001768	active site
399726001769	metal binding site [ion binding]; metal-binding site
399726001770	homotetramer interface [polypeptide binding]; other site
399726001771	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
399726001772	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
399726001773	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
399726001774	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
399726001775	Nitrogen regulatory protein P-II; Region: P-II; cl00412
399726001776	Nitrogen regulatory protein P-II; Region: P-II; smart00938
399726001777	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
399726001778	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
399726001779	catalytic triad [active]
399726001780	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
399726001781	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
399726001782	Glutamine amidotransferases class-II (Gn-AT)_GlxB-type.  GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907
399726001783	putative active site [active]
399726001784	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
399726001785	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
399726001786	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
399726001787	active site
399726001788	FMN binding site [chemical binding]; other site
399726001789	substrate binding site [chemical binding]; other site
399726001790	3Fe-4S cluster binding site [ion binding]; other site
399726001791	putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769
399726001792	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
399726001793	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726001794	Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981
399726001795	putative subunit interface; other site
399726001796	biotin synthase; Provisional; Region: PRK07094
399726001797	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726001798	FeS/SAM binding site; other site
399726001799	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
399726001800	Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186
399726001801	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
399726001802	putative active site [active]
399726001803	metal binding site [ion binding]; metal-binding site
399726001804	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
399726001805	dimer interface [polypeptide binding]; other site
399726001806	substrate binding site [chemical binding]; other site
399726001807	ATP binding site [chemical binding]; other site
399726001808	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
399726001809	thiamine phosphate binding site [chemical binding]; other site
399726001810	active site
399726001811	pyrophosphate binding site [ion binding]; other site
399726001812	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
399726001813	substrate binding site [chemical binding]; other site
399726001814	multimerization interface [polypeptide binding]; other site
399726001815	ATP binding site [chemical binding]; other site
399726001816	Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952
399726001817	Sodium:solute symporter family; Region: SSF; cl00456
399726001818	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
399726001819	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
399726001820	PhoU domain; Region: PhoU; pfam01895
399726001821	PhoU domain; Region: PhoU; pfam01895
399726001822	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
399726001823	LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids.  The  E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224
399726001824	Walker A/P-loop; other site
399726001825	ATP binding site [chemical binding]; other site
399726001826	Q-loop/lid; other site
399726001827	ABC transporter signature motif; other site
399726001828	Walker B; other site
399726001829	D-loop; other site
399726001830	H-loop/switch region; other site
399726001831	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
399726001832	Helix-turn-helix domains; Region: HTH; cl00088
399726001833	Integrase core domain; Region: rve; cl01316
399726001834	Helix-turn-helix domains; Region: HTH; cl00088
399726001835	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
399726001836	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
399726001837	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
399726001838	putative substrate binding site [chemical binding]; other site
399726001839	putative ATP binding site [chemical binding]; other site
399726001840	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
399726001841	active site
399726001842	phosphorylation site [posttranslational modification]
399726001843	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
399726001844	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
399726001845	P-loop; other site
399726001846	active site
399726001847	phosphorylation site [posttranslational modification]
399726001848	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
399726001849	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
399726001850	putative dimer interface [polypeptide binding]; other site
399726001851	CAAX protease self-immunity; Region: Abi; cl00558
399726001852	Transcriptional regulators [Transcription]; Region: PurR; COG1609
399726001853	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726001854	DNA binding site [nucleotide binding]
399726001855	domain linker motif; other site
399726001856	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
399726001857	putative dimerization interface [polypeptide binding]; other site
399726001858	putative ligand binding site [chemical binding]; other site
399726001859	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
399726001860	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
399726001861	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726001862	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
399726001863	pur operon repressor; Provisional; Region: PRK09213
399726001864	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
399726001865	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726001866	active site
399726001867	SpoVG; Region: SpoVG; cl00915
399726001868	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
399726001869	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
399726001870	Substrate binding site; other site
399726001871	Mg++ binding site; other site
399726001872	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
399726001873	active site
399726001874	substrate binding site [chemical binding]; other site
399726001875	CoA binding site [chemical binding]; other site
399726001876	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
399726001877	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
399726001878	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726001879	active site
399726001880	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
399726001881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726001882	active site
399726001883	phosphorylation site [posttranslational modification]
399726001884	intermolecular recognition site; other site
399726001885	dimerization interface [polypeptide binding]; other site
399726001886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
399726001887	DNA binding site [nucleotide binding]
399726001888	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
399726001889	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726001890	dimerization interface [polypeptide binding]; other site
399726001891	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
399726001892	dimer interface [polypeptide binding]; other site
399726001893	phosphorylation site [posttranslational modification]
399726001894	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726001895	ATP binding site [chemical binding]; other site
399726001896	Mg2+ binding site [ion binding]; other site
399726001897	G-X-G motif; other site
399726001898	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
399726001899	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
399726001900	protein binding site [polypeptide binding]; other site
399726001901	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
399726001902	putative active site [active]
399726001903	catalytic residue [active]
399726001904	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
399726001905	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
399726001906	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726001907	ATP binding site [chemical binding]; other site
399726001908	putative Mg++ binding site [ion binding]; other site
399726001909	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
399726001910	nucleotide binding region [chemical binding]; other site
399726001911	ATP-binding site [chemical binding]; other site
399726001912	TRCF domain; Region: TRCF; cl04088
399726001913	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
399726001914	SurA N-terminal domain; Region: SurA_N_3; cl07813
399726001915	PPIC-type PPIASE domain; Region: Rotamase; cl08278
399726001916	stage V sporulation protein T; Region: spore_V_T; TIGR02851
399726001917	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
399726001918	YabG peptidase U57; Region: Peptidase_U57; cl05250
399726001919	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
399726001920	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
399726001921	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
399726001922	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
399726001923	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726001924	putative peptidoglycan binding site; other site
399726001925	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
399726001926	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
399726001927	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
399726001928	Transcriptional regulators [Transcription]; Region: GntR; COG1802
399726001929	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
399726001930	DNA-binding site [nucleotide binding]; DNA binding site
399726001931	FCD domain; Region: FCD; cl11656
399726001932	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
399726001933	active site
399726001934	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
399726001935	Spore germination protein; Region: Spore_permease; cl15802
399726001936	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194
399726001937	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775
399726001938	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
399726001939	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726001940	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
399726001941	germination protein YpeB; Region: spore_YpeB; TIGR02889
399726001942	Peptidase propeptide and YPEB domain; Region: PepSY; cl15815
399726001943	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
399726001944	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
399726001945	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
399726001946	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726001947	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
399726001948	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
399726001949	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104
399726001950	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
399726001951	active site
399726001952	HIGH motif; other site
399726001953	KMSK motif region; other site
399726001954	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
399726001955	tRNA binding surface [nucleotide binding]; other site
399726001956	anticodon binding site; other site
399726001957	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726001958	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
399726001959	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
399726001960	glutamine binding [chemical binding]; other site
399726001961	catalytic triad [active]
399726001962	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
399726001963	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
399726001964	chorismate binding enzyme; Region: Chorismate_bind; cl10555
399726001965	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cd00449
399726001966	substrate-cofactor binding pocket; other site
399726001967	homodimer interface [polypeptide binding]; other site
399726001968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726001969	catalytic residue [active]
399726001970	FMN-binding domain; Region: FMN_bind; cl01081
399726001971	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726001972	putative substrate translocation pore; other site
399726001973	Major Facilitator Superfamily; Region: MFS_1; pfam07690
399726001974	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
399726001975	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
399726001976	Walker A/P-loop; other site
399726001977	ATP binding site [chemical binding]; other site
399726001978	Q-loop/lid; other site
399726001979	ABC transporter signature motif; other site
399726001980	Walker B; other site
399726001981	D-loop; other site
399726001982	H-loop/switch region; other site
399726001983	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
399726001984	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
399726001985	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
399726001986	Walker A/P-loop; other site
399726001987	ATP binding site [chemical binding]; other site
399726001988	Q-loop/lid; other site
399726001989	ABC transporter signature motif; other site
399726001990	Walker B; other site
399726001991	D-loop; other site
399726001992	H-loop/switch region; other site
399726001993	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
399726001994	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
399726001995	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
399726001996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726001997	dimer interface [polypeptide binding]; other site
399726001998	conserved gate region; other site
399726001999	putative PBP binding loops; other site
399726002000	ABC-ATPase subunit interface; other site
399726002001	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
399726002002	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726002003	dimer interface [polypeptide binding]; other site
399726002004	conserved gate region; other site
399726002005	putative PBP binding loops; other site
399726002006	ABC-ATPase subunit interface; other site
399726002007	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
399726002008	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
399726002009	peptide binding site [polypeptide binding]; other site
399726002010	AMP-binding enzyme; Region: AMP-binding; cl15778
399726002011	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
399726002012	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
399726002013	active site
399726002014	catalytic tetrad [active]
399726002015	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
399726002016	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
399726002017	SH3 domain of SH3b2 type; Region: SH3_7; pfam12914
399726002018	NlpC/P60 family; Region: NLPC_P60; cl11438
399726002019	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
399726002020	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
399726002021	putative catalytic cysteine [active]
399726002022	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
399726002023	putative active site [active]
399726002024	metal binding site [ion binding]; metal-binding site
399726002025	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
399726002026	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
399726002027	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
399726002028	DNA binding site [nucleotide binding]
399726002029	active site
399726002030	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
399726002031	putative DNA binding site [nucleotide binding]; other site
399726002032	putative Zn2+ binding site [ion binding]; other site
399726002033	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
399726002034	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726002035	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726002036	Walker A/P-loop; other site
399726002037	ATP binding site [chemical binding]; other site
399726002038	Q-loop/lid; other site
399726002039	ABC transporter signature motif; other site
399726002040	Walker B; other site
399726002041	D-loop; other site
399726002042	H-loop/switch region; other site
399726002043	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
399726002044	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726002045	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
399726002046	Walker A/P-loop; other site
399726002047	ATP binding site [chemical binding]; other site
399726002048	Q-loop/lid; other site
399726002049	ABC transporter signature motif; other site
399726002050	Walker B; other site
399726002051	D-loop; other site
399726002052	H-loop/switch region; other site
399726002053	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
399726002054	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
399726002055	active site
399726002056	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
399726002057	magnesium-transporting ATPase; Provisional; Region: PRK15122
399726002058	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
399726002059	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
399726002060	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726002061	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
399726002062	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
399726002063	Bacterial transcriptional regulator; Region: IclR; pfam01614
399726002064	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
399726002065	DNA binding residues [nucleotide binding]
399726002066	Helix-turn-helix domains; Region: HTH; cl00088
399726002067	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
399726002068	putative active site [active]
399726002069	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
399726002070	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726002071	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726002072	DNA binding residues [nucleotide binding]
399726002073	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
399726002074	Double zinc ribbon; Region: DZR; pfam12773
399726002075	zinc-ribbon domain; Region: zf-ribbon_3; cl11198
399726002076	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
399726002077	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
399726002078	This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity.  In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230
399726002079	Walker A/P-loop; other site
399726002080	ATP binding site [chemical binding]; other site
399726002081	Q-loop/lid; other site
399726002082	ABC transporter signature motif; other site
399726002083	Walker B; other site
399726002084	D-loop; other site
399726002085	H-loop/switch region; other site
399726002086	hypothetical protein; Provisional; Region: PRK08609
399726002087	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
399726002088	active site
399726002089	primer binding site [nucleotide binding]; other site
399726002090	NTP  binding site [chemical binding]; other site
399726002091	putative oxidoreductase; Provisional; Region: PRK12831
399726002092	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726002093	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
399726002094	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
399726002095	FAD binding pocket [chemical binding]; other site
399726002096	FAD binding motif [chemical binding]; other site
399726002097	phosphate binding motif [ion binding]; other site
399726002098	beta-alpha-beta structure motif; other site
399726002099	NAD binding pocket [chemical binding]; other site
399726002100	Iron coordination center [ion binding]; other site
399726002101	NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285
399726002102	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
399726002103	tetramer interface [polypeptide binding]; other site
399726002104	catalytic Zn binding site [ion binding]; other site
399726002105	NADP binding site [chemical binding]; other site
399726002106	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
399726002107	Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186
399726002108	putative active site [active]
399726002109	metal binding site [ion binding]; metal-binding site
399726002110	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
399726002111	4Fe-4S binding domain; Region: Fer4; cl02805
399726002112	4Fe-4S binding domain; Region: Fer4; cl02805
399726002113	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
399726002114	Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878
399726002115	Putative Fe-S cluster; Region: FeS; pfam04060
399726002116	PAS domain S-box; Region: sensory_box; TIGR00229
399726002117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
399726002118	putative active site [active]
399726002119	heme pocket [chemical binding]; other site
399726002120	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
399726002121	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
399726002122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726002123	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
399726002124	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
399726002125	heterotetramer interface [polypeptide binding]; other site
399726002126	active site pocket [active]
399726002127	cleavage site
399726002128	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
399726002129	feedback inhibition sensing region; other site
399726002130	homohexameric interface [polypeptide binding]; other site
399726002131	nucleotide binding site [chemical binding]; other site
399726002132	N-acetyl-L-glutamate binding site [chemical binding]; other site
399726002133	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
399726002134	acetylornithine aminotransferase; Provisional; Region: PRK02627
399726002135	inhibitor-cofactor binding pocket; inhibition site
399726002136	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726002137	catalytic residue [active]
399726002138	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
399726002139	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056
399726002140	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
399726002141	catalytic site [active]
399726002142	subunit interface [polypeptide binding]; other site
399726002143	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
399726002144	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
399726002145	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726002146	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
399726002147	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
399726002148	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726002149	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
399726002150	substrate binding site [chemical binding]; other site
399726002151	Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137
399726002152	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
399726002153	ANP binding site [chemical binding]; other site
399726002154	Substrate Binding Site II [chemical binding]; other site
399726002155	Substrate Binding Site I [chemical binding]; other site
399726002156	argininosuccinate lyase; Provisional; Region: PRK00855
399726002157	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
399726002158	active sites [active]
399726002159	tetramer interface [polypeptide binding]; other site
399726002160	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
399726002161	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
399726002162	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
399726002163	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
399726002164	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726002165	motif II; other site
399726002166	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
399726002167	PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882
399726002168	putative active site [active]
399726002169	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
399726002170	catalytic core [active]
399726002171	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
399726002172	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
399726002173	Ferritin-like domain; Region: Ferritin; pfam00210
399726002174	ferroxidase diiron center [ion binding]; other site
399726002175	Listerrria innocua Lin0431  is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911
399726002176	trimer interface [polypeptide binding]; other site
399726002177	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973
399726002178	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
399726002179	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
399726002180	substrate binding pocket [chemical binding]; other site
399726002181	chain length determination region; other site
399726002182	substrate-Mg2+ binding site; other site
399726002183	catalytic residues [active]
399726002184	aspartate-rich region 1; other site
399726002185	active site lid residues [active]
399726002186	aspartate-rich region 2; other site
399726002187	ApbE family; Region: ApbE; cl00643
399726002188	UbiA prenyltransferase family; Region: UbiA; cl00337
399726002189	FMN-binding domain; Region: FMN_bind; cl01081
399726002190	Protein of unknown function (DUF1237); Region: DUF1237; cl15402
399726002191	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
399726002192	Predicted amidohydrolase [General function prediction only]; Region: COG0388
399726002193	active site
399726002194	catalytic triad [active]
399726002195	dimer interface [polypeptide binding]; other site
399726002196	Predicted amidohydrolase [General function prediction only]; Region: COG0388
399726002197	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
399726002198	active site
399726002199	catalytic triad [active]
399726002200	dimer interface [polypeptide binding]; other site
399726002201	MFS/sugar transport protein; Region: MFS_2; pfam13347
399726002202	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
399726002203	desulfoferrodoxin; Region: dfx_rbo; TIGR00320
399726002204	Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974
399726002205	non-heme iron binding site [ion binding]; other site
399726002206	dimer interface [polypeptide binding]; other site
399726002207	Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171
399726002208	non-heme iron binding site [ion binding]; other site
399726002209	dimer interface [polypeptide binding]; other site
399726002210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726002211	ATP binding site [chemical binding]; other site
399726002212	G-X-G motif; other site
399726002213	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
399726002214	Aspartase; Region: Aspartase; cd01357
399726002215	active sites [active]
399726002216	tetramer interface [polypeptide binding]; other site
399726002217	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
399726002218	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
399726002219	G1 box; other site
399726002220	GTP/Mg2+ binding site [chemical binding]; other site
399726002221	Switch I region; other site
399726002222	G2 box; other site
399726002223	Switch II region; other site
399726002224	G3 box; other site
399726002225	G4 box; other site
399726002226	G5 box; other site
399726002227	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726002228	H+ Antiporter protein; Region: 2A0121; TIGR00900
399726002229	putative substrate translocation pore; other site
399726002230	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
399726002231	non-specific DNA binding site [nucleotide binding]; other site
399726002232	salt bridge; other site
399726002233	sequence-specific DNA binding site [nucleotide binding]; other site
399726002234	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
399726002235	Tetratricopeptide repeat; Region: TPR_12; pfam13424
399726002236	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
399726002237	binding surface
399726002238	TPR motif; other site
399726002239	Tetratricopeptide repeat; Region: TPR_12; pfam13424
399726002240	Tetratricopeptide repeat; Region: TPR_12; pfam13424
399726002241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
399726002242	Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304
399726002243	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
399726002244	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
399726002245	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
399726002246	IHF dimer interface [polypeptide binding]; other site
399726002247	IHF - DNA interface [nucleotide binding]; other site
399726002248	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
399726002249	Stage II sporulation protein; Region: SpoIID; pfam08486
399726002250	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
399726002251	YabP family; Region: YabP; cl06766
399726002252	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
399726002253	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
399726002254	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726002255	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869
399726002256	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597
399726002257	DRTGG domain; Region: DRTGG; cl12147
399726002258	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
399726002259	DHHA2 domain; Region: DHHA2; pfam02833
399726002260	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
399726002261	Septum formation initiator; Region: DivIC; cl11433
399726002262	hypothetical protein; Provisional; Region: PRK05807
399726002263	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692
399726002264	RNA binding site [nucleotide binding]; other site
399726002265	Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449
399726002266	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
399726002267	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
399726002268	catalytic residues [active]
399726002269	catalytic nucleophile [active]
399726002270	Recombinase; Region: Recombinase; pfam07508
399726002271	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
399726002272	peptide chain release factor 1; Validated; Region: prfA; PRK00591
399726002273	Domain of unknown function (DUF955); Region: DUF955; cl01076
399726002274	YokU-like protein; Region: YokU; cl15819
399726002275	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
399726002276	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
399726002277	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
399726002278	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
399726002279	non-specific DNA binding site [nucleotide binding]; other site
399726002280	salt bridge; other site
399726002281	sequence-specific DNA binding site [nucleotide binding]; other site
399726002282	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
399726002283	non-specific DNA binding site [nucleotide binding]; other site
399726002284	salt bridge; other site
399726002285	sequence-specific DNA binding site [nucleotide binding]; other site
399726002286	Helix-turn-helix domains; Region: HTH; cl00088
399726002287	TIR domain; Region: TIR_2; cl15770
399726002288	PrgI family protein; Region: PrgI; pfam12666
399726002289	AAA-like domain; Region: AAA_10; pfam12846
399726002290	Domain of unknown function DUF87; Region: DUF87; pfam01935
399726002291	Peptidase family M23; Region: Peptidase_M23; pfam01551
399726002292	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
399726002293	N-acetyl-D-glucosamine binding site [chemical binding]; other site
399726002294	catalytic residue [active]
399726002295	SAF domain; Region: SAF; cl00555
399726002296	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
399726002297	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
399726002298	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
399726002299	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
399726002300	Walker A motif; other site
399726002301	hexamer interface [polypeptide binding]; other site
399726002302	ATP binding site [chemical binding]; other site
399726002303	Walker B motif; other site
399726002304	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
399726002305	AAA domain; Region: AAA_31; pfam13614
399726002306	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726002307	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726002308	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726002309	Zn2+ binding site [ion binding]; other site
399726002310	Mg2+ binding site [ion binding]; other site
399726002311	plasmid segregation protein ParM; Provisional; Region: PRK13917
399726002312	StbA protein; Region: StbA; pfam06406
399726002313	Radical SAM superfamily; Region: Radical_SAM; pfam04055
399726002314	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726002315	FeS/SAM binding site; other site
399726002316	Replication-relaxation; Region: Replic_Relax; pfam13814
399726002317	conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743
399726002318	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
399726002319	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
399726002320	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726002321	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
399726002322	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
399726002323	SdpI/YhfL protein family; Region: SdpI; pfam13630
399726002324	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
399726002325	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
399726002326	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
399726002327	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726002328	putative active site [active]
399726002329	putative NTP binding site [chemical binding]; other site
399726002330	putative nucleic acid binding site [nucleotide binding]; other site
399726002331	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
399726002332	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
399726002333	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
399726002334	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726002335	Walker A motif; other site
399726002336	ATP binding site [chemical binding]; other site
399726002337	Walker B motif; other site
399726002338	arginine finger; other site
399726002339	Helix-turn-helix domains; Region: HTH; cl00088
399726002340	Helix-turn-helix domains; Region: HTH; cl00088
399726002341	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
399726002342	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726002343	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
399726002344	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726002345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726002346	dimer interface [polypeptide binding]; other site
399726002347	conserved gate region; other site
399726002348	putative PBP binding loops; other site
399726002349	ABC-ATPase subunit interface; other site
399726002350	DDE domain; Region: DDE_Tnp_IS240; pfam13610
399726002351	Integrase core domain; Region: rve; cl01316
399726002352	Integrase core domain; Region: rve_3; cl15866
399726002353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726002354	dimer interface [polypeptide binding]; other site
399726002355	conserved gate region; other site
399726002356	putative PBP binding loops; other site
399726002357	ABC-ATPase subunit interface; other site
399726002358	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
399726002359	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
399726002360	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
399726002361	Helix-turn-helix domains; Region: HTH; cl00088
399726002362	Integrase core domain; Region: rve; cl01316
399726002363	DDE domain; Region: DDE_Tnp_IS240; pfam13610
399726002364	Integrase core domain; Region: rve_3; cl15866
399726002365	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
399726002366	YppF-like protein; Region: YppF; pfam14178
399726002367	Short C-terminal domain; Region: SHOCT; cl01373
399726002368	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
399726002369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726002370	active site
399726002371	phosphorylation site [posttranslational modification]
399726002372	intermolecular recognition site; other site
399726002373	dimerization interface [polypeptide binding]; other site
399726002374	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
399726002375	DNA binding site [nucleotide binding]
399726002376	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726002377	dimerization interface [polypeptide binding]; other site
399726002378	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
399726002379	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
399726002380	dimer interface [polypeptide binding]; other site
399726002381	phosphorylation site [posttranslational modification]
399726002382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726002383	ATP binding site [chemical binding]; other site
399726002384	Mg2+ binding site [ion binding]; other site
399726002385	G-X-G motif; other site
399726002386	Short C-terminal domain; Region: SHOCT; cl01373
399726002387	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
399726002388	dimerization interface [polypeptide binding]; other site
399726002389	putative DNA binding site [nucleotide binding]; other site
399726002390	putative Zn2+ binding site [ion binding]; other site
399726002391	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
399726002392	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
399726002393	metal-binding site [ion binding]
399726002394	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
399726002395	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726002396	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
399726002397	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
399726002398	dimer interface [polypeptide binding]; other site
399726002399	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726002400	catalytic residue [active]
399726002401	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
399726002402	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
399726002403	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726002404	catalytic residue [active]
399726002405	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
399726002406	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
399726002407	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
399726002408	metal-binding site [ion binding]
399726002409	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
399726002410	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
399726002411	metal-binding site [ion binding]
399726002412	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
399726002413	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726002414	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
399726002415	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
399726002416	active site
399726002417	metal binding site [ion binding]; metal-binding site
399726002418	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
399726002419	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
399726002420	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
399726002421	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
399726002422	substrate-cofactor binding pocket; other site
399726002423	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726002424	catalytic residue [active]
399726002425	Threonine dehydrogenase; Region: TDH; cd05281
399726002426	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
399726002427	structural Zn binding site [ion binding]; other site
399726002428	catalytic Zn binding site [ion binding]; other site
399726002429	tetramer interface [polypeptide binding]; other site
399726002430	NADP binding site [chemical binding]; other site
399726002431	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
399726002432	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
399726002433	dimer interface [polypeptide binding]; other site
399726002434	PYR/PP interface [polypeptide binding]; other site
399726002435	TPP binding site [chemical binding]; other site
399726002436	substrate binding site [chemical binding]; other site
399726002437	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
399726002438	Domain of unknown function; Region: EKR; cl11037
399726002439	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
399726002440	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
399726002441	TPP-binding site [chemical binding]; other site
399726002442	dimer interface [polypeptide binding]; other site
399726002443	Domain of unknown function (DUF3787); Region: DUF3787; pfam12655
399726002444	Protein of unknown function (DUF1284); Region: DUF1284; cl01419
399726002445	ABC-2 type transporter; Region: ABC2_membrane; cl11417
399726002446	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
399726002447	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726002448	Walker A/P-loop; other site
399726002449	ATP binding site [chemical binding]; other site
399726002450	Q-loop/lid; other site
399726002451	ABC transporter signature motif; other site
399726002452	Walker B; other site
399726002453	D-loop; other site
399726002454	H-loop/switch region; other site
399726002455	Putative zinc-finger; Region: zf-HC2; cl15806
399726002456	Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039
399726002457	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
399726002458	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726002459	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726002460	EamA-like transporter family; Region: EamA; cl01037
399726002461	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
399726002462	EamA-like transporter family; Region: EamA; cl01037
399726002463	stage II sporulation protein E; Region: spore_II_E; TIGR02865
399726002464	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
399726002465	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
399726002466	Ligand Binding Site [chemical binding]; other site
399726002467	Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072
399726002468	B3/4 domain; Region: B3_4; cl11458
399726002469	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726002470	active site
399726002471	FtsH Extracellular; Region: FtsH_ext; pfam06480
399726002472	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
399726002473	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726002474	Walker A motif; other site
399726002475	ATP binding site [chemical binding]; other site
399726002476	Walker B motif; other site
399726002477	arginine finger; other site
399726002478	Peptidase family M41; Region: Peptidase_M41; pfam01434
399726002479	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
399726002480	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
399726002481	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
399726002482	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
399726002483	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
399726002484	dimer interface [polypeptide binding]; other site
399726002485	phosphorylation site [posttranslational modification]
399726002486	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726002487	ATP binding site [chemical binding]; other site
399726002488	Mg2+ binding site [ion binding]; other site
399726002489	G-X-G motif; other site
399726002490	Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268
399726002491	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
399726002492	Potassium binding sites [ion binding]; other site
399726002493	Cesium cation binding sites [ion binding]; other site
399726002494	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
399726002495	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
399726002496	Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772
399726002497	pyruvate carboxylase subunit B; Validated; Region: PRK09282
399726002498	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
399726002499	carboxyltransferase (CT) interaction site; other site
399726002500	biotinylation site [posttranslational modification]; other site
399726002501	Predicted membrane protein [Function unknown]; Region: COG4684
399726002502	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
399726002503	Type III pantothenate kinase; Region: Pan_kinase; cl09130
399726002504	Spore germination protein; Region: Spore_permease; cl15802
399726002505	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
399726002506	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194
399726002507	Predicted dehydrogenase [General function prediction only]; Region: COG5322
399726002508	NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078
399726002509	NADP binding site [chemical binding]; other site
399726002510	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
399726002511	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
399726002512	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
399726002513	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
399726002514	dimer interface [polypeptide binding]; other site
399726002515	putative anticodon binding site; other site
399726002516	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
399726002517	motif 1; other site
399726002518	active site
399726002519	motif 2; other site
399726002520	motif 3; other site
399726002521	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
399726002522	homodecamer interface [polypeptide binding]; other site
399726002523	GTP cyclohydrolase I; Provisional; Region: PLN03044
399726002524	active site
399726002525	putative catalytic site residues [active]
399726002526	zinc binding site [ion binding]; other site
399726002527	GTP-CH-I/GFRP interaction surface; other site
399726002528	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
399726002529	dihydropteroate synthase; Region: DHPS; TIGR01496
399726002530	substrate binding pocket [chemical binding]; other site
399726002531	dimer interface [polypeptide binding]; other site
399726002532	inhibitor binding site; inhibition site
399726002533	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
399726002534	catalytic center binding site [active]
399726002535	ATP binding site [chemical binding]; other site
399726002536	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
399726002537	active site
399726002538	Sugar fermentation stimulation protein; Region: SfsA; cl00647
399726002539	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
399726002540	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
399726002541	Protein of unknown function (DUF1614); Region: DUF1614; cl15407
399726002542	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
399726002543	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
399726002544	inhibitor-cofactor binding pocket; inhibition site
399726002545	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726002546	catalytic residue [active]
399726002547	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
399726002548	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
399726002549	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
399726002550	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
399726002551	active site
399726002552	dimer interface [polypeptide binding]; other site
399726002553	effector binding site; other site
399726002554	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
399726002555	TSCPD domain; Region: TSCPD; cl14834
399726002556	GAF domain; Region: GAF_2; pfam13185
399726002557	GAF domain; Region: GAF; cl15785
399726002558	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
399726002559	metal binding site [ion binding]; metal-binding site
399726002560	active site
399726002561	I-site; other site
399726002562	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
399726002563	Helix-turn-helix domains; Region: HTH; cl00088
399726002564	Helix-turn-helix domains; Region: HTH; cl00088
399726002565	PRD domain; Region: PRD; cl15445
399726002566	PRD domain; Region: PRD; cl15445
399726002567	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
399726002568	P-loop; other site
399726002569	active site
399726002570	phosphorylation site [posttranslational modification]
399726002571	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
399726002572	active site
399726002573	phosphorylation site [posttranslational modification]
399726002574	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
399726002575	active site
399726002576	phosphorylation site [posttranslational modification]
399726002577	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557
399726002578	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
399726002579	P-loop; other site
399726002580	active site
399726002581	phosphorylation site [posttranslational modification]
399726002582	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
399726002583	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
399726002584	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
399726002585	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
399726002586	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
399726002587	elongation factor G; Reviewed; Region: PRK12740
399726002588	G1 box; other site
399726002589	putative GEF interaction site [polypeptide binding]; other site
399726002590	GTP/Mg2+ binding site [chemical binding]; other site
399726002591	Switch I region; other site
399726002592	G2 box; other site
399726002593	G3 box; other site
399726002594	Switch II region; other site
399726002595	G4 box; other site
399726002596	G5 box; other site
399726002597	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
399726002598	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
399726002599	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
399726002600	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
399726002601	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726002602	putative active site [active]
399726002603	putative NTP binding site [chemical binding]; other site
399726002604	putative nucleic acid binding site [nucleotide binding]; other site
399726002605	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
399726002606	Malic enzyme, N-terminal domain; Region: malic; pfam00390
399726002607	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
399726002608	putative NAD(P) binding site [chemical binding]; other site
399726002609	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850
399726002610	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
399726002611	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
399726002612	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
399726002613	ADP binding site [chemical binding]; other site
399726002614	phosphagen binding site; other site
399726002615	substrate specificity loop; other site
399726002616	Clp protease ATP binding subunit; Region: clpC; CHL00095
399726002617	Clp amino terminal domain; Region: Clp_N; pfam02861
399726002618	Clp amino terminal domain; Region: Clp_N; pfam02861
399726002619	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726002620	Walker A motif; other site
399726002621	ATP binding site [chemical binding]; other site
399726002622	Walker B motif; other site
399726002623	arginine finger; other site
399726002624	UvrB/uvrC motif; Region: UVR; pfam02151
399726002625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726002626	Walker A motif; other site
399726002627	ATP binding site [chemical binding]; other site
399726002628	Walker B motif; other site
399726002629	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
399726002630	DNA repair protein RadA; Provisional; Region: PRK11823
399726002631	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
399726002632	Walker A motif/ATP binding site; other site
399726002633	ATP binding site [chemical binding]; other site
399726002634	Walker B motif; other site
399726002635	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
399726002636	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
399726002637	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
399726002638	putative active site [active]
399726002639	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
399726002640	substrate binding site; other site
399726002641	dimer interface; other site
399726002642	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
399726002643	Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450
399726002644	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
399726002645	homotrimer interaction site [polypeptide binding]; other site
399726002646	zinc binding site [ion binding]; other site
399726002647	CDP-binding sites; other site
399726002648	prolyl-tRNA synthetase; Provisional; Region: PRK09194
399726002649	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779
399726002650	dimer interface [polypeptide binding]; other site
399726002651	motif 1; other site
399726002652	active site
399726002653	motif 2; other site
399726002654	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
399726002655	putative deacylase active site [active]
399726002656	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
399726002657	active site
399726002658	motif 3; other site
399726002659	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
399726002660	anticodon binding site; other site
399726002661	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
399726002662	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
399726002663	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
399726002664	HIGH motif; other site
399726002665	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
399726002666	active site
399726002667	KMSKS motif; other site
399726002668	serine O-acetyltransferase; Region: cysE; TIGR01172
399726002669	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
399726002670	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
399726002671	trimer interface [polypeptide binding]; other site
399726002672	active site
399726002673	substrate binding site [chemical binding]; other site
399726002674	CoA binding site [chemical binding]; other site
399726002675	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
399726002676	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
399726002677	active site
399726002678	HIGH motif; other site
399726002679	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
399726002680	KMSKS motif; other site
399726002681	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
399726002682	tRNA binding surface [nucleotide binding]; other site
399726002683	anticodon binding site; other site
399726002684	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
399726002685	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
399726002686	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
399726002687	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
399726002688	YacP-like NYN domain; Region: NYN_YacP; cl01491
399726002689	RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859
399726002690	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726002691	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726002692	elongation factor Tu; Reviewed; Region: PRK00049
399726002693	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
399726002694	G1 box; other site
399726002695	GEF interaction site [polypeptide binding]; other site
399726002696	GTP/Mg2+ binding site [chemical binding]; other site
399726002697	Switch I region; other site
399726002698	G2 box; other site
399726002699	G3 box; other site
399726002700	Switch II region; other site
399726002701	G4 box; other site
399726002702	G5 box; other site
399726002703	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
399726002704	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
399726002705	Antibiotic Binding Site [chemical binding]; other site
399726002706	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481
399726002707	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
399726002708	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
399726002709	putative homodimer interface [polypeptide binding]; other site
399726002710	KOW motif; Region: KOW; cl00354
399726002711	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
399726002712	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
399726002713	23S rRNA interface [nucleotide binding]; other site
399726002714	L7/L12 interface [polypeptide binding]; other site
399726002715	putative thiostrepton binding site; other site
399726002716	L25 interface [polypeptide binding]; other site
399726002717	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
399726002718	mRNA/rRNA interface [nucleotide binding]; other site
399726002719	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
399726002720	23S rRNA interface [nucleotide binding]; other site
399726002721	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
399726002722	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
399726002723	core dimer interface [polypeptide binding]; other site
399726002724	peripheral dimer interface [polypeptide binding]; other site
399726002725	L10 interface [polypeptide binding]; other site
399726002726	L11 interface [polypeptide binding]; other site
399726002727	putative EF-Tu interaction site [polypeptide binding]; other site
399726002728	putative EF-G interaction site [polypeptide binding]; other site
399726002729	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
399726002730	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593
399726002731	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
399726002732	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
399726002733	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
399726002734	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
399726002735	RPB1 interaction site [polypeptide binding]; other site
399726002736	RPB10 interaction site [polypeptide binding]; other site
399726002737	RPB11 interaction site [polypeptide binding]; other site
399726002738	RPB3 interaction site [polypeptide binding]; other site
399726002739	RPB12 interaction site [polypeptide binding]; other site
399726002740	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
399726002741	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
399726002742	RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591
399726002743	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
399726002744	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
399726002745	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
399726002746	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
399726002747	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
399726002748	G-loop; other site
399726002749	DNA binding site [nucleotide binding]
399726002750	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
399726002751	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
399726002752	S17 interaction site [polypeptide binding]; other site
399726002753	S8 interaction site; other site
399726002754	16S rRNA interaction site [nucleotide binding]; other site
399726002755	streptomycin interaction site [chemical binding]; other site
399726002756	23S rRNA interaction site [nucleotide binding]; other site
399726002757	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
399726002758	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
399726002759	elongation factor G; Reviewed; Region: PRK00007
399726002760	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
399726002761	G1 box; other site
399726002762	putative GEF interaction site [polypeptide binding]; other site
399726002763	GTP/Mg2+ binding site [chemical binding]; other site
399726002764	Switch I region; other site
399726002765	G2 box; other site
399726002766	G3 box; other site
399726002767	Switch II region; other site
399726002768	G4 box; other site
399726002769	G5 box; other site
399726002770	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
399726002771	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
399726002772	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
399726002773	elongation factor Tu; Reviewed; Region: PRK00049
399726002774	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
399726002775	G1 box; other site
399726002776	GEF interaction site [polypeptide binding]; other site
399726002777	GTP/Mg2+ binding site [chemical binding]; other site
399726002778	Switch I region; other site
399726002779	G2 box; other site
399726002780	G3 box; other site
399726002781	Switch II region; other site
399726002782	G4 box; other site
399726002783	G5 box; other site
399726002784	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
399726002785	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
399726002786	Antibiotic Binding Site [chemical binding]; other site
399726002787	Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314
399726002788	Ribosomal protein L3; Region: Ribosomal_L3; cl00324
399726002789	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
399726002790	Ribosomal protein L23; Region: Ribosomal_L23; cl00326
399726002791	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
399726002792	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
399726002793	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
399726002794	Ribosomal protein S19; Region: Ribosomal_S19; cl00350
399726002795	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
399726002796	putative translocon binding site; other site
399726002797	protein-rRNA interface [nucleotide binding]; other site
399726002798	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
399726002799	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
399726002800	G-X-X-G motif; other site
399726002801	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
399726002802	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
399726002803	23S rRNA interface [nucleotide binding]; other site
399726002804	5S rRNA interface [nucleotide binding]; other site
399726002805	putative antibiotic binding site [chemical binding]; other site
399726002806	L25 interface [polypeptide binding]; other site
399726002807	L27 interface [polypeptide binding]; other site
399726002808	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
399726002809	23S rRNA interface [nucleotide binding]; other site
399726002810	putative translocon interaction site; other site
399726002811	signal recognition particle (SRP54) interaction site; other site
399726002812	L23 interface [polypeptide binding]; other site
399726002813	trigger factor interaction site; other site
399726002814	Ribosomal protein S17; Region: Ribosomal_S17; cl00351
399726002815	Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328
399726002816	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
399726002817	KOW motif; Region: KOW; cl00354
399726002818	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
399726002819	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
399726002820	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
399726002821	Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355
399726002822	Ribosomal protein S8; Region: Ribosomal_S8; cl00330
399726002823	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
399726002824	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
399726002825	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
399726002826	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
399726002827	5S rRNA interface [nucleotide binding]; other site
399726002828	L27 interface [polypeptide binding]; other site
399726002829	23S rRNA interface [nucleotide binding]; other site
399726002830	L5 interface [polypeptide binding]; other site
399726002831	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
399726002832	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
399726002833	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
399726002834	Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022
399726002835	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
399726002836	SecY translocase; Region: SecY; pfam00344
399726002837	adenylate kinase; Reviewed; Region: adk; PRK00279
399726002838	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
399726002839	AMP-binding site [chemical binding]; other site
399726002840	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
399726002841	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
399726002842	active site
399726002843	Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163
399726002844	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
399726002845	rRNA binding site [nucleotide binding]; other site
399726002846	predicted 30S ribosome binding site; other site
399726002847	Ribosomal protein L36; Region: Ribosomal_L36; cl00380
399726002848	Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331
399726002849	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
399726002850	Ribosomal protein S11; Region: Ribosomal_S11; cl00332
399726002851	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
399726002852	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
399726002853	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
399726002854	RNA binding surface [nucleotide binding]; other site
399726002855	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
399726002856	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
399726002857	alphaNTD homodimer interface [polypeptide binding]; other site
399726002858	alphaNTD - beta interaction site [polypeptide binding]; other site
399726002859	alphaNTD - beta' interaction site [polypeptide binding]; other site
399726002860	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613
399726002861	Ribosomal protein L17; Region: Ribosomal_L17; cl00356
399726002862	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
399726002863	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726002864	Walker A/P-loop; other site
399726002865	ATP binding site [chemical binding]; other site
399726002866	Q-loop/lid; other site
399726002867	ABC transporter signature motif; other site
399726002868	Walker B; other site
399726002869	D-loop; other site
399726002870	H-loop/switch region; other site
399726002871	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
399726002872	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726002873	Walker A/P-loop; other site
399726002874	ATP binding site [chemical binding]; other site
399726002875	Q-loop/lid; other site
399726002876	ABC transporter signature motif; other site
399726002877	Walker B; other site
399726002878	D-loop; other site
399726002879	H-loop/switch region; other site
399726002880	Cobalt transport protein; Region: CbiQ; cl00463
399726002881	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
399726002882	PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570
399726002883	dimerization interface 3.5A [polypeptide binding]; other site
399726002884	active site
399726002885	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
399726002886	23S rRNA interface [nucleotide binding]; other site
399726002887	L3 interface [polypeptide binding]; other site
399726002888	Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334
399726002889	CGNR zinc finger; Region: zf-CGNR; pfam11706
399726002890	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
399726002891	diiron binding motif [ion binding]; other site
399726002892	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
399726002893	non-heme iron binding site [ion binding]; other site
399726002894	tetramer interface [polypeptide binding]; other site
399726002895	Carbon starvation protein CstA; Region: CstA; pfam02554
399726002896	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
399726002897	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
399726002898	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
399726002899	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
399726002900	Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154
399726002901	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
399726002902	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
399726002903	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
399726002904	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492
399726002905	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375
399726002906	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
399726002907	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234
399726002908	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187
399726002909	Transporter associated domain; Region: CorC_HlyC; cl08393
399726002910	Thymidylate synthase complementing protein; Region: Thy1; cl03630
399726002911	Thymidylate synthase complementing protein; Region: Thy1; cl03630
399726002912	Coat F domain; Region: Coat_F; cl15836
399726002913	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
399726002914	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726002915	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726002916	putative peptidoglycan binding site; other site
399726002917	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
399726002918	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726002919	putative peptidoglycan binding site; other site
399726002920	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726002921	putative peptidoglycan binding site; other site
399726002922	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726002923	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726002924	putative peptidoglycan binding site; other site
399726002925	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
399726002926	active site
399726002927	metal binding site [ion binding]; metal-binding site
399726002928	pyrophosphatase PpaX; Provisional; Region: PRK13288
399726002929	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726002930	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726002931	motif II; other site
399726002932	MoxR-like ATPases [General function prediction only]; Region: COG0714
399726002933	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726002934	Walker A motif; other site
399726002935	ATP binding site [chemical binding]; other site
399726002936	Walker B motif; other site
399726002937	arginine finger; other site
399726002938	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
399726002939	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
399726002940	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
399726002941	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
399726002942	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
399726002943	Ligand Binding Site [chemical binding]; other site
399726002944	BON domain; Region: BON; cl02771
399726002945	BON domain; Region: BON; cl02771
399726002946	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726002947	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726002948	Uncharacterized conserved protein [Function unknown]; Region: COG1624
399726002949	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
399726002950	YbbR-like protein; Region: YbbR; pfam07949
399726002951	YbbR-like protein; Region: YbbR; pfam07949
399726002952	YbbR-like protein; Region: YbbR; pfam07949
399726002953	Acetokinase family; Region: Acetate_kinase; cl01029
399726002954	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
399726002955	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
399726002956	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
399726002957	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
399726002958	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
399726002959	NAD binding site [chemical binding]; other site
399726002960	Phe binding site; other site
399726002961	Acetokinase family; Region: Acetate_kinase; cl01029
399726002962	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
399726002963	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726002964	Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143
399726002965	4Fe-4S binding domain; Region: Fer4; cl02805
399726002966	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
399726002967	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
399726002968	dimer interface [polypeptide binding]; other site
399726002969	PYR/PP interface [polypeptide binding]; other site
399726002970	TPP binding site [chemical binding]; other site
399726002971	substrate binding site [chemical binding]; other site
399726002972	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
399726002973	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
399726002974	TPP-binding site [chemical binding]; other site
399726002975	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
399726002976	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
399726002977	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
399726002978	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
399726002979	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
399726002980	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
399726002981	dimer interface [polypeptide binding]; other site
399726002982	PYR/PP interface [polypeptide binding]; other site
399726002983	TPP binding site [chemical binding]; other site
399726002984	substrate binding site [chemical binding]; other site
399726002985	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
399726002986	TPP-binding site; other site
399726002987	4Fe-4S binding domain; Region: Fer4; cl02805
399726002988	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
399726002989	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
399726002990	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
399726002991	putative acyl-acceptor binding pocket; other site
399726002992	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
399726002993	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
399726002994	active site
399726002995	substrate binding site [chemical binding]; other site
399726002996	metal binding site [ion binding]; metal-binding site
399726002997	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
399726002998	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
399726002999	glutaminase active site [active]
399726003000	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
399726003001	dimer interface [polypeptide binding]; other site
399726003002	active site
399726003003	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
399726003004	dimer interface [polypeptide binding]; other site
399726003005	active site
399726003006	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
399726003007	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
399726003008	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
399726003009	active site
399726003010	DNA binding site [nucleotide binding]
399726003011	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
399726003012	DNA binding site [nucleotide binding]
399726003013	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
399726003014	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
399726003015	putative DNA binding site [nucleotide binding]; other site
399726003016	putative homodimer interface [polypeptide binding]; other site
399726003017	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726003018	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726003019	putative peptidoglycan binding site; other site
399726003020	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726003021	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
399726003022	Protein of unknown function (DUF503); Region: DUF503; cl00669
399726003023	hybrid cluster protein; Provisional; Region: PRK05290
399726003024	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
399726003025	ACS interaction site; other site
399726003026	CODH interaction site; other site
399726003027	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
399726003028	hybrid metal cluster; other site
399726003029	transcriptional repressor DicA; Reviewed; Region: PRK09706
399726003030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
399726003031	non-specific DNA binding site [nucleotide binding]; other site
399726003032	salt bridge; other site
399726003033	sequence-specific DNA binding site [nucleotide binding]; other site
399726003034	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726003035	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
399726003036	putative carbohydrate kinase; Provisional; Region: PRK10565
399726003037	YjeF-related protein N-terminus; Region: YjeF_N; cl00318
399726003038	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
399726003039	putative substrate binding site [chemical binding]; other site
399726003040	putative ATP binding site [chemical binding]; other site
399726003041	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065
399726003042	alanine racemase; Reviewed; Region: alr; PRK00053
399726003043	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
399726003044	active site
399726003045	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
399726003046	dimer interface [polypeptide binding]; other site
399726003047	substrate binding site [chemical binding]; other site
399726003048	catalytic residues [active]
399726003049	Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15783
399726003050	PemK-like protein; Region: PemK; cl00995
399726003051	Uncharacterized conserved protein [Function unknown]; Region: COG1284
399726003052	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
399726003053	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
399726003054	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
399726003055	TPP-binding site [chemical binding]; other site
399726003056	dimer interface [polypeptide binding]; other site
399726003057	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
399726003058	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
399726003059	PYR/PP interface [polypeptide binding]; other site
399726003060	dimer interface [polypeptide binding]; other site
399726003061	TPP binding site [chemical binding]; other site
399726003062	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
399726003063	Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739
399726003064	Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918
399726003065	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
399726003066	active site
399726003067	ADP/pyrophosphate binding site [chemical binding]; other site
399726003068	fructose-1,6-bisphosphate binding site; other site
399726003069	dimerization interface [polypeptide binding]; other site
399726003070	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
399726003071	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
399726003072	Rubredoxin; Region: Rubredoxin; pfam00301
399726003073	iron binding site [ion binding]; other site
399726003074	ThiC family; Region: ThiC; cl08031
399726003075	Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460
399726003076	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003077	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
399726003078	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
399726003079	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
399726003080	homodimer interface [polypeptide binding]; other site
399726003081	substrate-cofactor binding pocket; other site
399726003082	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726003083	catalytic residue [active]
399726003084	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
399726003085	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
399726003086	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
399726003087	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003088	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
399726003089	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
399726003090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726003091	S-adenosylmethionine binding site [chemical binding]; other site
399726003092	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; cl01283
399726003093	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
399726003094	V-type ATP synthase subunit I; Validated; Region: PRK05771
399726003095	Putative glucoamylase; Region: Glycoamylase; pfam10091
399726003096	Putative carbohydrate binding domain; Region: CBM_X; cl05621
399726003097	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
399726003098	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
399726003099	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
399726003100	Putative carbohydrate binding domain; Region: CBM_X; cl05621
399726003101	Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165
399726003102	Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205
399726003103	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801
399726003104	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
399726003105	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726003106	Walker A/P-loop; other site
399726003107	ATP binding site [chemical binding]; other site
399726003108	Q-loop/lid; other site
399726003109	ABC transporter signature motif; other site
399726003110	Walker B; other site
399726003111	D-loop; other site
399726003112	H-loop/switch region; other site
399726003113	ABC-2 type transporter; Region: ABC2_membrane; cl11417
399726003114	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
399726003115	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
399726003116	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
399726003117	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
399726003118	Transcriptional regulators [Transcription]; Region: PurR; COG1609
399726003119	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726003120	DNA binding site [nucleotide binding]
399726003121	domain linker motif; other site
399726003122	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
399726003123	dimerization interface [polypeptide binding]; other site
399726003124	ligand binding site [chemical binding]; other site
399726003125	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
399726003126	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
399726003127	DNA interaction; other site
399726003128	Metal-binding active site; metal-binding site
399726003129	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316
399726003130	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
399726003131	putative ligand binding site [chemical binding]; other site
399726003132	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
399726003133	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003134	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
399726003135	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
399726003136	This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216
399726003137	Walker A/P-loop; other site
399726003138	ATP binding site [chemical binding]; other site
399726003139	Q-loop/lid; other site
399726003140	ABC transporter signature motif; other site
399726003141	Walker B; other site
399726003142	D-loop; other site
399726003143	H-loop/switch region; other site
399726003144	This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos).  The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215
399726003145	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
399726003146	TM-ABC transporter signature motif; other site
399726003147	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
399726003148	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
399726003149	DNA interaction; other site
399726003150	Metal-binding active site; metal-binding site
399726003151	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
399726003152	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
399726003153	catalytic site [active]
399726003154	metal binding site [ion binding]; metal-binding site
399726003155	carbohydrate binding site [chemical binding]; other site
399726003156	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
399726003157	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003158	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
399726003159	HEPN domain; Region: HEPN; cl00824
399726003160	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
399726003161	active site
399726003162	NTP binding site [chemical binding]; other site
399726003163	metal binding triad [ion binding]; metal-binding site
399726003164	antibiotic binding site [chemical binding]; other site
399726003165	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
399726003166	putative active site [active]
399726003167	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
399726003168	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
399726003169	dimer interface [polypeptide binding]; other site
399726003170	motif 1; other site
399726003171	active site
399726003172	motif 2; other site
399726003173	motif 3; other site
399726003174	ATP phosphoribosyltransferase; Region: HisG; cl15266
399726003175	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
399726003176	histidinol dehydrogenase; Region: hisD; TIGR00069
399726003177	NAD binding site [chemical binding]; other site
399726003178	dimerization interface [polypeptide binding]; other site
399726003179	product binding site; other site
399726003180	substrate binding site [chemical binding]; other site
399726003181	zinc binding site [ion binding]; other site
399726003182	catalytic residues [active]
399726003183	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
399726003184	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
399726003185	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726003186	homodimer interface [polypeptide binding]; other site
399726003187	catalytic residue [active]
399726003188	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
399726003189	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
399726003190	putative active site pocket [active]
399726003191	4-fold oligomerization interface [polypeptide binding]; other site
399726003192	metal binding residues [ion binding]; metal-binding site
399726003193	3-fold/trimer interface [polypeptide binding]; other site
399726003194	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
399726003195	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
399726003196	putative active site [active]
399726003197	oxyanion strand; other site
399726003198	catalytic triad [active]
399726003199	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
399726003200	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
399726003201	catalytic residues [active]
399726003202	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
399726003203	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
399726003204	substrate binding site [chemical binding]; other site
399726003205	glutamase interaction surface [polypeptide binding]; other site
399726003206	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
399726003207	Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344
399726003208	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
399726003209	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
399726003210	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
399726003211	dimer interface [polypeptide binding]; other site
399726003212	glycine-pyridoxal phosphate binding site [chemical binding]; other site
399726003213	active site
399726003214	folate binding site [chemical binding]; other site
399726003215	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
399726003216	active site
399726003217	dimer interface [polypeptide binding]; other site
399726003218	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
399726003219	Spore germination protein; Region: Spore_permease; cl15802
399726003220	Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704
399726003221	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
399726003222	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
399726003223	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
399726003224	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
399726003225	active site
399726003226	Substrate binding site; other site
399726003227	Mg++ binding site; other site
399726003228	Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356
399726003229	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
399726003230	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
399726003231	active site
399726003232	substrate binding site [chemical binding]; other site
399726003233	metal binding site [ion binding]; metal-binding site
399726003234	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
399726003235	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
399726003236	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
399726003237	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
399726003238	NodB motif; other site
399726003239	active site
399726003240	catalytic site [active]
399726003241	Cd binding site [ion binding]; other site
399726003242	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
399726003243	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
399726003244	amphipathic channel; other site
399726003245	Asn-Pro-Ala signature motifs; other site
399726003246	glycerol kinase; Provisional; Region: glpK; PRK00047
399726003247	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
399726003248	N- and C-terminal domain interface [polypeptide binding]; other site
399726003249	active site
399726003250	MgATP binding site [chemical binding]; other site
399726003251	catalytic site [active]
399726003252	metal binding site [ion binding]; metal-binding site
399726003253	glycerol binding site [chemical binding]; other site
399726003254	homotetramer interface [polypeptide binding]; other site
399726003255	homodimer interface [polypeptide binding]; other site
399726003256	FBP binding site [chemical binding]; other site
399726003257	protein IIAGlc interface [polypeptide binding]; other site
399726003258	Predicted dehydrogenase [General function prediction only]; Region: COG0579
399726003259	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003260	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
399726003261	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
399726003262	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726003263	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
399726003264	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
399726003265	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
399726003266	dimerization domain swap beta strand [polypeptide binding]; other site
399726003267	regulatory protein interface [polypeptide binding]; other site
399726003268	active site
399726003269	regulatory phosphorylation site [posttranslational modification]; other site
399726003270	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
399726003271	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
399726003272	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726003273	Walker A motif; other site
399726003274	ATP binding site [chemical binding]; other site
399726003275	Walker B motif; other site
399726003276	arginine finger; other site
399726003277	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
399726003278	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
399726003279	DAK2 domain; Region: Dak2; cl03685
399726003280	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
399726003281	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
399726003282	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726003283	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
399726003284	HEAT repeats; Region: HEAT_2; pfam13646
399726003285	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
399726003286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726003287	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
399726003288	Walker A motif; other site
399726003289	ATP binding site [chemical binding]; other site
399726003290	Walker B motif; other site
399726003291	arginine finger; other site
399726003292	Peptidase family M41; Region: Peptidase_M41; pfam01434
399726003293	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726003294	cell division protein FtsA; Region: ftsA; TIGR01174
399726003295	Cell division protein FtsA; Region: FtsA; cl11496
399726003296	Cell division protein FtsA; Region: FtsA; cl11496
399726003297	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
399726003298	active site
399726003299	NTP binding site [chemical binding]; other site
399726003300	metal binding triad [ion binding]; metal-binding site
399726003301	antibiotic binding site [chemical binding]; other site
399726003302	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495
399726003303	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
399726003304	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726003305	motif II; other site
399726003306	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
399726003307	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
399726003308	5S rRNA interface [nucleotide binding]; other site
399726003309	CTC domain interface [polypeptide binding]; other site
399726003310	L16 interface [polypeptide binding]; other site
399726003311	diaminopimelate decarboxylase; Region: lysA; TIGR01048
399726003312	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
399726003313	active site
399726003314	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
399726003315	substrate binding site [chemical binding]; other site
399726003316	catalytic residues [active]
399726003317	dimer interface [polypeptide binding]; other site
399726003318	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
399726003319	The N-terminal ATPase domain of the maltose transporter, MalK.  ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles.  ABC transporters contain two...; Region: ABC_MalK_N; cd03301
399726003320	Walker A/P-loop; other site
399726003321	ATP binding site [chemical binding]; other site
399726003322	Q-loop/lid; other site
399726003323	ABC transporter signature motif; other site
399726003324	Walker B; other site
399726003325	D-loop; other site
399726003326	H-loop/switch region; other site
399726003327	TOBE domain; Region: TOBE_2; cl01440
399726003328	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
399726003329	Helix-turn-helix domains; Region: HTH; cl00088
399726003330	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
399726003331	FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane.  The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292
399726003332	Walker A/P-loop; other site
399726003333	ATP binding site [chemical binding]; other site
399726003334	Q-loop/lid; other site
399726003335	ABC transporter signature motif; other site
399726003336	Walker B; other site
399726003337	D-loop; other site
399726003338	H-loop/switch region; other site
399726003339	FtsX-like permease family; Region: FtsX; cl15850
399726003340	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
399726003341	Peptidase family M23; Region: Peptidase_M23; pfam01551
399726003342	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
399726003343	C-terminal peptidase (prc); Region: prc; TIGR00225
399726003344	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
399726003345	protein binding site [polypeptide binding]; other site
399726003346	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
399726003347	Catalytic dyad [active]
399726003348	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
399726003349	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895
399726003350	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
399726003351	excinuclease ABC subunit B; Provisional; Region: PRK05298
399726003352	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726003353	ATP binding site [chemical binding]; other site
399726003354	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
399726003355	nucleotide binding region [chemical binding]; other site
399726003356	ATP-binding site [chemical binding]; other site
399726003357	Ultra-violet resistance protein B; Region: UvrB; pfam12344
399726003358	UvrB/uvrC motif; Region: UVR; pfam02151
399726003359	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
399726003360	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
399726003361	The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270
399726003362	The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion.  Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271
399726003363	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
399726003364	phosphopeptide binding site; other site
399726003365	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
399726003366	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
399726003367	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726003368	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
399726003369	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
399726003370	GIY-YIG motif/motif A; other site
399726003371	active site
399726003372	catalytic site [active]
399726003373	putative DNA binding site [nucleotide binding]; other site
399726003374	metal binding site [ion binding]; metal-binding site
399726003375	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
399726003376	Helix-turn-helix domains; Region: HTH; cl00088
399726003377	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
399726003378	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
399726003379	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
399726003380	HPr kinase/phosphorylase; Provisional; Region: PRK05428
399726003381	DRTGG domain; Region: DRTGG; cl12147
399726003382	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
399726003383	Hpr binding site; other site
399726003384	active site
399726003385	homohexamer subunit interaction site [polypeptide binding]; other site
399726003386	putative hydrolase; Validated; Region: PRK09248
399726003387	RNase P subunit p30; Region: RNase_P_p30; cl03389
399726003388	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
399726003389	FGGY family of carbohydrate kinases; Region: FGGY; cl08364
399726003390	catalytic site [active]
399726003391	metal binding site [ion binding]; metal-binding site
399726003392	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
399726003393	AMP-binding enzyme; Region: AMP-binding; cl15778
399726003394	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
399726003395	Protein of unknown function, DUF624; Region: DUF624; cl02369
399726003396	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
399726003397	active site
399726003398	NTP binding site [chemical binding]; other site
399726003399	metal binding triad [ion binding]; metal-binding site
399726003400	hypothetical protein; Provisional; Region: PRK03881
399726003401	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
399726003402	AMMECR1; Region: AMMECR1; cl00911
399726003403	Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180
399726003404	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726003405	FeS/SAM binding site; other site
399726003406	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
399726003407	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
399726003408	Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452
399726003409	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
399726003410	DNA binding residues [nucleotide binding]
399726003411	Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769
399726003412	catalytic residues [active]
399726003413	catalytic nucleophile [active]
399726003414	transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765
399726003415	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
399726003416	Transcriptional regulators [Transcription]; Region: PurR; COG1609
399726003417	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726003418	DNA binding site [nucleotide binding]
399726003419	domain linker motif; other site
399726003420	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
399726003421	dimerization interface [polypeptide binding]; other site
399726003422	ligand binding site [chemical binding]; other site
399726003423	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
399726003424	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003425	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
399726003426	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
399726003427	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003428	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611
399726003429	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
399726003430	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
399726003431	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
399726003432	AP (apurinic/apyrimidinic) site pocket; other site
399726003433	DNA interaction; other site
399726003434	Metal-binding active site; metal-binding site
399726003435	Membrane transport protein; Region: Mem_trans; cl09117
399726003436	glyoxylate reductase; Reviewed; Region: PRK13243
399726003437	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003438	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
399726003439	Helix-turn-helix domains; Region: HTH; cl00088
399726003440	SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339
399726003441	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
399726003442	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003443	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003444	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
399726003445	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
399726003446	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
399726003447	gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
399726003448	N- and C-terminal domain interface [polypeptide binding]; other site
399726003449	putative active site [active]
399726003450	catalytic site [active]
399726003451	metal binding site [ion binding]; metal-binding site
399726003452	carbohydrate binding site [chemical binding]; other site
399726003453	ATP binding site [chemical binding]; other site
399726003454	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
399726003455	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
399726003456	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
399726003457	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
399726003458	galactokinase; Provisional; Region: PRK05322
399726003459	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
399726003460	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
399726003461	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
399726003462	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
399726003463	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
399726003464	NAD binding site [chemical binding]; other site
399726003465	homodimer interface [polypeptide binding]; other site
399726003466	active site
399726003467	substrate binding site [chemical binding]; other site
399726003468	Helix-turn-helix domains; Region: HTH; cl00088
399726003469	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
399726003470	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726003471	Domain of unknown function (DUF4380); Region: DUF4380; pfam14315
399726003472	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726003473	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
399726003474	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
399726003475	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
399726003476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003477	dimer interface [polypeptide binding]; other site
399726003478	conserved gate region; other site
399726003479	putative PBP binding loops; other site
399726003480	ABC-ATPase subunit interface; other site
399726003481	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003482	dimer interface [polypeptide binding]; other site
399726003483	conserved gate region; other site
399726003484	putative PBP binding loops; other site
399726003485	ABC-ATPase subunit interface; other site
399726003486	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
399726003487	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
399726003488	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; cl08371
399726003489	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
399726003490	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
399726003491	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl01383
399726003492	Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074
399726003493	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
399726003494	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
399726003495	MFS/sugar transport protein; Region: MFS_2; pfam13347
399726003496	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
399726003497	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
399726003498	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726003499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003500	dimer interface [polypeptide binding]; other site
399726003501	conserved gate region; other site
399726003502	putative PBP binding loops; other site
399726003503	ABC-ATPase subunit interface; other site
399726003504	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
399726003505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003506	dimer interface [polypeptide binding]; other site
399726003507	conserved gate region; other site
399726003508	putative PBP binding loops; other site
399726003509	ABC-ATPase subunit interface; other site
399726003510	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
399726003511	Cupin domain; Region: Cupin_2; cl09118
399726003512	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
399726003513	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
399726003514	Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023
399726003515	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
399726003516	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
399726003517	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726003518	Walker A motif; other site
399726003519	ATP binding site [chemical binding]; other site
399726003520	Walker B motif; other site
399726003521	arginine finger; other site
399726003522	Helix-turn-helix domains; Region: HTH; cl00088
399726003523	Integrase core domain; Region: rve; cl01316
399726003524	Integrase core domain; Region: rve_3; cl15866
399726003525	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
399726003526	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726003527	Walker A motif; other site
399726003528	ATP binding site [chemical binding]; other site
399726003529	Walker B motif; other site
399726003530	arginine finger; other site
399726003531	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
399726003532	active site
399726003533	intersubunit interactions; other site
399726003534	catalytic residue [active]
399726003535	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726003536	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
399726003537	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
399726003538	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
399726003539	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726003540	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
399726003541	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726003542	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003543	dimer interface [polypeptide binding]; other site
399726003544	conserved gate region; other site
399726003545	putative PBP binding loops; other site
399726003546	ABC-ATPase subunit interface; other site
399726003547	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
399726003548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003549	dimer interface [polypeptide binding]; other site
399726003550	conserved gate region; other site
399726003551	putative PBP binding loops; other site
399726003552	ABC-ATPase subunit interface; other site
399726003553	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
399726003554	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
399726003555	substrate binding [chemical binding]; other site
399726003556	active site
399726003557	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
399726003558	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
399726003559	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
399726003560	putative substrate binding site [chemical binding]; other site
399726003561	putative ATP binding site [chemical binding]; other site
399726003562	Transcriptional regulators [Transcription]; Region: PurR; COG1609
399726003563	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726003564	DNA binding site [nucleotide binding]
399726003565	domain linker motif; other site
399726003566	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
399726003567	dimerization interface [polypeptide binding]; other site
399726003568	ligand binding site [chemical binding]; other site
399726003569	sodium binding site [ion binding]; other site
399726003570	Predicted methyltransferases [General function prediction only]; Region: COG1568
399726003571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726003572	Methyltransferase domain; Region: Methyltransf_31; pfam13847
399726003573	S-adenosylmethionine binding site [chemical binding]; other site
399726003574	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
399726003575	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
399726003576	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
399726003577	switch II; other site
399726003578	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
399726003579	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
399726003580	switch II; other site
399726003581	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726003582	biotin synthase; Provisional; Region: PRK07094
399726003583	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726003584	FeS/SAM binding site; other site
399726003585	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
399726003586	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
399726003587	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726003588	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
399726003589	Metal binding protein HemV-2.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147
399726003590	putative metal binding site [ion binding]; other site
399726003591	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
399726003592	ABC-ATPase subunit  interface; other site
399726003593	dimer interface [polypeptide binding]; other site
399726003594	putative PBP binding regions; other site
399726003595	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
399726003596	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
399726003597	Walker A/P-loop; other site
399726003598	ATP binding site [chemical binding]; other site
399726003599	Q-loop/lid; other site
399726003600	ABC transporter signature motif; other site
399726003601	Walker B; other site
399726003602	D-loop; other site
399726003603	H-loop/switch region; other site
399726003604	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
399726003605	homodimer interaction site [polypeptide binding]; other site
399726003606	cofactor binding site; other site
399726003607	Protein of unknown function (DUF1847); Region: DUF1847; cl02037
399726003608	FeoA domain; Region: FeoA; cl00838
399726003609	FeoA domain; Region: FeoA; cl00838
399726003610	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
399726003611	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
399726003612	G1 box; other site
399726003613	GTP/Mg2+ binding site [chemical binding]; other site
399726003614	Switch I region; other site
399726003615	G2 box; other site
399726003616	G3 box; other site
399726003617	Switch II region; other site
399726003618	G4 box; other site
399726003619	G5 box; other site
399726003620	Nucleoside recognition; Region: Gate; cl00486
399726003621	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
399726003622	Nucleoside recognition; Region: Gate; cl00486
399726003623	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726003624	Zn2+ binding site [ion binding]; other site
399726003625	Mg2+ binding site [ion binding]; other site
399726003626	ferric uptake regulator; Provisional; Region: fur; PRK09462
399726003627	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
399726003628	metal binding site 2 [ion binding]; metal-binding site
399726003629	putative DNA binding helix; other site
399726003630	metal binding site 1 [ion binding]; metal-binding site
399726003631	dimer interface [polypeptide binding]; other site
399726003632	structural Zn2+ binding site [ion binding]; other site
399726003633	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
399726003634	ATP cone domain; Region: ATP-cone; pfam03477
399726003635	Class III ribonucleotide reductase; Region: RNR_III; cd01675
399726003636	effector binding site; other site
399726003637	active site
399726003638	Zn binding site [ion binding]; other site
399726003639	glycine loop; other site
399726003640	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
399726003641	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726003642	FeS/SAM binding site; other site
399726003643	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
399726003644	PAS domain; Region: PAS_9; pfam13426
399726003645	putative active site [active]
399726003646	heme pocket [chemical binding]; other site
399726003647	PAS domain S-box; Region: sensory_box; TIGR00229
399726003648	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
399726003649	putative active site [active]
399726003650	heme pocket [chemical binding]; other site
399726003651	PAS domain S-box; Region: sensory_box; TIGR00229
399726003652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
399726003653	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
399726003654	metal binding site [ion binding]; metal-binding site
399726003655	active site
399726003656	I-site; other site
399726003657	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726003658	Zn2+ binding site [ion binding]; other site
399726003659	Mg2+ binding site [ion binding]; other site
399726003660	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726003661	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
399726003662	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
399726003663	metal-binding site [ion binding]
399726003664	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
399726003665	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
399726003666	dimer interface [polypeptide binding]; other site
399726003667	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726003668	catalytic residue [active]
399726003669	biotin synthase; Provisional; Region: PRK07094
399726003670	Helix-turn-helix domains; Region: HTH; cl00088
399726003671	Short C-terminal domain; Region: SHOCT; cl01373
399726003672	Short C-terminal domain; Region: SHOCT; cl01373
399726003673	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
399726003674	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726003675	active site
399726003676	phosphorylation site [posttranslational modification]
399726003677	intermolecular recognition site; other site
399726003678	dimerization interface [polypeptide binding]; other site
399726003679	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
399726003680	DNA binding site [nucleotide binding]
399726003681	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726003682	dimerization interface [polypeptide binding]; other site
399726003683	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
399726003684	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
399726003685	dimer interface [polypeptide binding]; other site
399726003686	phosphorylation site [posttranslational modification]
399726003687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726003688	ATP binding site [chemical binding]; other site
399726003689	Mg2+ binding site [ion binding]; other site
399726003690	G-X-G motif; other site
399726003691	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
399726003692	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
399726003693	putative ATP binding site [chemical binding]; other site
399726003694	putative substrate interface [chemical binding]; other site
399726003695	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
399726003696	Ligand Binding Site [chemical binding]; other site
399726003697	TIGR00269 family protein; Region: TIGR00269
399726003698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
399726003699	dimerization interface [polypeptide binding]; other site
399726003700	putative DNA binding site [nucleotide binding]; other site
399726003701	putative Zn2+ binding site [ion binding]; other site
399726003702	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
399726003703	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
399726003704	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726003705	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
399726003706	metal-binding site [ion binding]
399726003707	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
399726003708	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
399726003709	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726003710	catalytic residue [active]
399726003711	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726003712	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726003713	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
399726003714	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726003715	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726003716	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
399726003717	CoenzymeA binding site [chemical binding]; other site
399726003718	subunit interaction site [polypeptide binding]; other site
399726003719	PHB binding site; other site
399726003720	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
399726003721	catalytic triad [active]
399726003722	conserved cis-peptide bond; other site
399726003723	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
399726003724	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
399726003725	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
399726003726	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
399726003727	active site
399726003728	ATP binding site [chemical binding]; other site
399726003729	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
399726003730	Helix-turn-helix domains; Region: HTH; cl00088
399726003731	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
399726003732	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
399726003733	active site
399726003734	nucleophile elbow; other site
399726003735	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
399726003736	FAD binding domain; Region: FAD_binding_4; pfam01565
399726003737	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
399726003738	putative hydrolase; Validated; Region: PRK09248
399726003739	RNase P subunit p30; Region: RNase_P_p30; cl03389
399726003740	P-loop ATPase protein family; Region: ATP_bind_2; cl15794
399726003741	Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660
399726003742	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
399726003743	Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933
399726003744	phosphate binding site [ion binding]; other site
399726003745	putative substrate binding pocket [chemical binding]; other site
399726003746	dimer interface [polypeptide binding]; other site
399726003747	Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320
399726003748	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
399726003749	Ca binding site [ion binding]; other site
399726003750	active site
399726003751	catalytic site [active]
399726003752	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
399726003753	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
399726003754	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726003755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003756	dimer interface [polypeptide binding]; other site
399726003757	conserved gate region; other site
399726003758	ABC-ATPase subunit interface; other site
399726003759	ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833
399726003760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003761	dimer interface [polypeptide binding]; other site
399726003762	conserved gate region; other site
399726003763	putative PBP binding loops; other site
399726003764	ABC-ATPase subunit interface; other site
399726003765	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
399726003766	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
399726003767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
399726003768	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
399726003769	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726003770	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
399726003771	maltodextrin glucosidase; Provisional; Region: PRK10785
399726003772	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
399726003773	homodimer interface [polypeptide binding]; other site
399726003774	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
399726003775	active site
399726003776	homodimer interface [polypeptide binding]; other site
399726003777	catalytic site [active]
399726003778	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
399726003779	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
399726003780	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
399726003781	dimerization domain swap beta strand [polypeptide binding]; other site
399726003782	regulatory protein interface [polypeptide binding]; other site
399726003783	active site
399726003784	regulatory phosphorylation site [posttranslational modification]; other site
399726003785	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
399726003786	DRTGG domain; Region: DRTGG; cl12147
399726003787	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
399726003788	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
399726003789	active site 2 [active]
399726003790	active site 1 [active]
399726003791	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
399726003792	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
399726003793	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
399726003794	generic binding surface II; other site
399726003795	generic binding surface I; other site
399726003796	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
399726003797	active site
399726003798	ADP/pyrophosphate binding site [chemical binding]; other site
399726003799	dimerization interface [polypeptide binding]; other site
399726003800	allosteric effector site; other site
399726003801	fructose-1,6-bisphosphate binding site; other site
399726003802	pyruvate kinase; Provisional; Region: PRK06354
399726003803	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
399726003804	domain interfaces; other site
399726003805	active site
399726003806	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
399726003807	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
399726003808	active site
399726003809	TRAM domain; Region: TRAM; cl01282
399726003810	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
399726003811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726003812	S-adenosylmethionine binding site [chemical binding]; other site
399726003813	Membrane transport protein; Region: Mem_trans; cl09117
399726003814	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
399726003815	MatE; Region: MatE; cl10513
399726003816	MatE; Region: MatE; cl10513
399726003817	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
399726003818	DNA-binding site [nucleotide binding]; DNA binding site
399726003819	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
399726003820	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
399726003821	OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment.  ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295
399726003822	Walker A/P-loop; other site
399726003823	ATP binding site [chemical binding]; other site
399726003824	Q-loop/lid; other site
399726003825	ABC transporter signature motif; other site
399726003826	Walker B; other site
399726003827	D-loop; other site
399726003828	H-loop/switch region; other site
399726003829	FOG: CBS domain [General function prediction only]; Region: COG0517
399726003830	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
399726003831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726003832	dimer interface [polypeptide binding]; other site
399726003833	conserved gate region; other site
399726003834	ABC-ATPase subunit interface; other site
399726003835	NMT1-like family; Region: NMT1_2; cl15260
399726003836	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
399726003837	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
399726003838	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
399726003839	active site
399726003840	catalytic residues [active]
399726003841	metal binding site [ion binding]; metal-binding site
399726003842	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212
399726003843	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
399726003844	peptidase T; Region: peptidase-T; TIGR01882
399726003845	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
399726003846	metal binding site [ion binding]; metal-binding site
399726003847	dimer interface [polypeptide binding]; other site
399726003848	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
399726003849	putative FMN binding site [chemical binding]; other site
399726003850	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
399726003851	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
399726003852	active site
399726003853	dimer interface [polypeptide binding]; other site
399726003854	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
399726003855	dimer interface [polypeptide binding]; other site
399726003856	active site
399726003857	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
399726003858	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
399726003859	Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219
399726003860	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
399726003861	FAD binding site [chemical binding]; other site
399726003862	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
399726003863	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
399726003864	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
399726003865	substrate binding pocket [chemical binding]; other site
399726003866	dimer interface [polypeptide binding]; other site
399726003867	inhibitor binding site; inhibition site
399726003868	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
399726003869	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
399726003870	B12 binding site [chemical binding]; other site
399726003871	cobalt ligand [ion binding]; other site
399726003872	Uncharacterized conserved protein [Function unknown]; Region: COG3760
399726003873	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
399726003874	putative deacylase active site [active]
399726003875	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
399726003876	dimanganese center [ion binding]; other site
399726003877	CotJB protein; Region: CotJB; pfam12652
399726003878	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
399726003879	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
399726003880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726003881	S-adenosylmethionine binding site [chemical binding]; other site
399726003882	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447
399726003883	GIY-YIG motif/motif A; other site
399726003884	putative active site [active]
399726003885	putative metal binding site [ion binding]; other site
399726003886	Domain of unknown function (DUF4357); Region: DUF4357; pfam14267
399726003887	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
399726003888	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
399726003889	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726003890	ATP binding site [chemical binding]; other site
399726003891	putative Mg++ binding site [ion binding]; other site
399726003892	TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271
399726003893	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
399726003894	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
399726003895	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
399726003896	HsdM N-terminal domain; Region: HsdM_N; pfam12161
399726003897	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
399726003898	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003899	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726003900	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726003901	HsdM N-terminal domain; Region: HsdM_N; pfam12161
399726003902	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
399726003903	Predicted ATPase [General function prediction only]; Region: COG5293
399726003904	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726003905	Walker A/P-loop; other site
399726003906	ATP binding site [chemical binding]; other site
399726003907	RNA polymerase sigma factor; Provisional; Region: PRK12513
399726003908	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726003909	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
399726003910	Protein of unknown function (DUF2815); Region: DUF2815; pfam10991
399726003911	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_A; cd08642
399726003912	active site
399726003913	DNA binding site [nucleotide binding]
399726003914	catalytic site [active]
399726003915	BRO family, N-terminal domain; Region: Bro-N; cl10591
399726003916	Phage antirepressor protein KilAC domain; Region: ANT; cl01462
399726003917	Virulence-associated protein E; Region: VirE; pfam05272
399726003918	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
399726003919	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726003920	ATP binding site [chemical binding]; other site
399726003921	putative Mg++ binding site [ion binding]; other site
399726003922	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726003923	nucleotide binding region [chemical binding]; other site
399726003924	ATP-binding site [chemical binding]; other site
399726003925	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
399726003926	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
399726003927	active site
399726003928	Phage terminase, small subunit; Region: Terminase_4; cl01525
399726003929	S-adenosylmethionine synthetase; Provisional; Region: PRK12459
399726003930	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
399726003931	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
399726003932	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
399726003933	ParB-like nuclease domain; Region: ParBc; cl02129
399726003934	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726003935	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726003936	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
399726003937	putative active site [active]
399726003938	putative NTP binding site [chemical binding]; other site
399726003939	putative nucleic acid binding site [nucleotide binding]; other site
399726003940	Domain of unknown function (DUF4314); Region: DUF4314; pfam14192
399726003941	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
399726003942	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
399726003943	putative active site pocket [active]
399726003944	dimerization interface [polypeptide binding]; other site
399726003945	putative catalytic residue [active]
399726003946	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
399726003947	Phage Terminase; Region: Terminase_1; pfam03354
399726003948	Phage-related protein [Function unknown]; Region: COG4695; cl01923
399726003949	Phage portal protein; Region: Phage_portal; pfam04860
399726003950	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
399726003951	oligomer interface [polypeptide binding]; other site
399726003952	active site residues [active]
399726003953	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
399726003954	Phage capsid family; Region: Phage_capsid; pfam05065
399726003955	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
399726003956	oligomerization interface [polypeptide binding]; other site
399726003957	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
399726003958	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
399726003959	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
399726003960	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
399726003961	Phage-related protein [Function unknown]; Region: COG5412
399726003962	tape measure domain; Region: tape_meas_nterm; TIGR02675
399726003963	Phage-related protein [Function unknown]; Region: COG4722; cl15832
399726003964	Phage tail protein; Region: Sipho_tail; pfam05709
399726003965	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
399726003966	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
399726003967	active site
399726003968	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
399726003969	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
399726003970	Holin family; Region: Phage_holin_4; cl01989
399726003971	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
399726003972	amidase catalytic site [active]
399726003973	Zn binding residues [ion binding]; other site
399726003974	substrate binding site [chemical binding]; other site
399726003975	Sporulation related domain; Region: SPOR; cl10051
399726003976	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
399726003977	catalytic residues [active]
399726003978	catalytic nucleophile [active]
399726003979	Recombinase; Region: Recombinase; pfam07508
399726003980	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
399726003981	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
399726003982	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
399726003983	catalytic residues [active]
399726003984	catalytic nucleophile [active]
399726003985	Recombinase; Region: Recombinase; pfam07508
399726003986	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
399726003987	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
399726003988	dimerization interface [polypeptide binding]; other site
399726003989	putative DNA binding site [nucleotide binding]; other site
399726003990	putative Zn2+ binding site [ion binding]; other site
399726003991	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
399726003992	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
399726003993	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
399726003994	metal-binding site [ion binding]
399726003995	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
399726003996	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726003997	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
399726003998	lipoprotein signal peptidase; Provisional; Region: PRK14787
399726003999	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
399726004000	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
399726004001	Uncharacterized conserved protein [Function unknown]; Region: COG2128
399726004002	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
399726004003	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
399726004004	active site
399726004005	nucleophile elbow; other site
399726004006	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
399726004007	HIRAN domain; Region: HIRAN; cl07418
399726004008	recombination factor protein RarA; Reviewed; Region: PRK13342
399726004009	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726004010	Walker A motif; other site
399726004011	ATP binding site [chemical binding]; other site
399726004012	Walker B motif; other site
399726004013	arginine finger; other site
399726004014	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
399726004015	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
399726004016	YokU-like protein; Region: YokU; cl15819
399726004017	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
399726004018	nudix motif; other site
399726004019	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
399726004020	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
399726004021	active site
399726004022	Radical SAM superfamily; Region: Radical_SAM; pfam04055
399726004023	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004024	FeS/SAM binding site; other site
399726004025	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
399726004026	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
399726004027	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
399726004028	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
399726004029	active site
399726004030	Cache domain; Region: Cache_1; pfam02743
399726004031	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
399726004032	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004033	FeS/SAM binding site; other site
399726004034	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
399726004035	Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420
399726004036	Helix-turn-helix domains; Region: HTH; cl00088
399726004037	4Fe-4S binding domain; Region: Fer4; cl02805
399726004038	4Fe-4S single cluster domain; Region: Fer4_13; pfam13370
399726004039	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
399726004040	AAA domain; Region: AAA_32; pfam13654
399726004041	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
399726004042	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
399726004043	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
399726004044	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
399726004045	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
399726004046	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
399726004047	minor groove reading motif; other site
399726004048	helix-hairpin-helix signature motif; other site
399726004049	active site
399726004050	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304
399726004051	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
399726004052	VanW like protein; Region: VanW; pfam04294
399726004053	G5 domain; Region: G5; pfam07501
399726004054	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
399726004055	metal binding site 2 [ion binding]; metal-binding site
399726004056	putative DNA binding helix; other site
399726004057	metal binding site 1 [ion binding]; metal-binding site
399726004058	dimer interface [polypeptide binding]; other site
399726004059	structural Zn2+ binding site [ion binding]; other site
399726004060	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726004061	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
399726004062	active site
399726004063	motif I; other site
399726004064	motif II; other site
399726004065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726004066	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726004067	Acylphosphatase; Region: Acylphosphatase; cl00551
399726004068	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
399726004069	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
399726004070	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004071	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
399726004072	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
399726004073	Phosphoglycerate kinase; Region: PGK; pfam00162
399726004074	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
399726004075	substrate binding site [chemical binding]; other site
399726004076	hinge regions; other site
399726004077	ADP binding site [chemical binding]; other site
399726004078	catalytic site [active]
399726004079	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
399726004080	substrate binding site [chemical binding]; other site
399726004081	dimer interface [polypeptide binding]; other site
399726004082	catalytic triad [active]
399726004083	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
399726004084	Sulfatase; Region: Sulfatase; cl10460
399726004085	enolase; Provisional; Region: eno; PRK00077
399726004086	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
399726004087	dimer interface [polypeptide binding]; other site
399726004088	metal binding site [ion binding]; metal-binding site
399726004089	substrate binding pocket [chemical binding]; other site
399726004090	Preprotein translocase SecG subunit; Region: SecG; cl09123
399726004091	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
399726004092	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726004093	Zn2+ binding site [ion binding]; other site
399726004094	Mg2+ binding site [ion binding]; other site
399726004095	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
399726004096	DNA primase; Validated; Region: dnaG; PRK05667
399726004097	CHC2 zinc finger; Region: zf-CHC2; cl15369
399726004098	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
399726004099	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
399726004100	active site
399726004101	metal binding site [ion binding]; metal-binding site
399726004102	interdomain interaction site; other site
399726004103	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
399726004104	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
399726004105	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
399726004106	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
399726004107	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726004108	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
399726004109	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726004110	DNA binding residues [nucleotide binding]
399726004111	Transposase domain (DUF772); Region: DUF772; cl15789
399726004112	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
399726004113	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004114	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
399726004115	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
399726004116	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
399726004117	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
399726004118	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
399726004119	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
399726004120	Phosphomannose isomerase type I; Region: PMI_typeI; cl15429
399726004121	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
399726004122	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
399726004123	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
399726004124	Predicted permeases [General function prediction only]; Region: COG0701
399726004125	Predicted permease; Region: DUF318; pfam03773
399726004126	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
399726004127	dimerization interface [polypeptide binding]; other site
399726004128	putative DNA binding site [nucleotide binding]; other site
399726004129	putative Zn2+ binding site [ion binding]; other site
399726004130	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726004131	putative active site [active]
399726004132	putative NTP binding site [chemical binding]; other site
399726004133	putative nucleic acid binding site [nucleotide binding]; other site
399726004134	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
399726004135	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726004136	Walker A motif; other site
399726004137	ATP binding site [chemical binding]; other site
399726004138	Walker B motif; other site
399726004139	arginine finger; other site
399726004140	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
399726004141	GtrA-like protein; Region: GtrA; cl00971
399726004142	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl15769
399726004143	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
399726004144	radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089
399726004145	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
399726004146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004147	FeS/SAM binding site; other site
399726004148	TRAM domain; Region: TRAM; cl01282
399726004149	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
399726004150	nucleotide binding site/active site [active]
399726004151	HIT family signature motif; other site
399726004152	catalytic residue [active]
399726004153	Ribosomal protein S21; Region: Ribosomal_S21; cl00529
399726004154	GatB domain; Region: GatB_Yqey; cl11497
399726004155	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
399726004156	active site
399726004157	homotetramer interface [polypeptide binding]; other site
399726004158	homodimer interface [polypeptide binding]; other site
399726004159	YabP family; Region: YabP; cl06766
399726004160	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
399726004161	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
399726004162	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004163	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
399726004164	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
399726004165	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
399726004166	Zn2+ binding site [ion binding]; other site
399726004167	Mg2+ binding site [ion binding]; other site
399726004168	Uncharacterized protein family UPF0054; Region: UPF0054; cl00402
399726004169	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526
399726004170	PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383
399726004171	active site
399726004172	GTPase Era; Reviewed; Region: era; PRK00089
399726004173	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
399726004174	G1 box; other site
399726004175	GTP/Mg2+ binding site [chemical binding]; other site
399726004176	Switch I region; other site
399726004177	G2 box; other site
399726004178	Switch II region; other site
399726004179	G3 box; other site
399726004180	G4 box; other site
399726004181	G5 box; other site
399726004182	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
399726004183	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
399726004184	intersubunit interface [polypeptide binding]; other site
399726004185	active site
399726004186	catalytic residue [active]
399726004187	Recombination protein O N terminal; Region: RecO_N; cl15812
399726004188	DNA repair protein RecO; Region: reco; TIGR00613
399726004189	Recombination protein O C terminal; Region: RecO_C; pfam02565
399726004190	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
399726004191	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
399726004192	glycyl-tRNA synthetase; Provisional; Region: PRK04173
399726004193	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
399726004194	motif 1; other site
399726004195	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774
399726004196	active site
399726004197	motif 2; other site
399726004198	motif 3; other site
399726004199	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
399726004200	anticodon binding site; other site
399726004201	Helix-turn-helix domains; Region: HTH; cl00088
399726004202	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
399726004203	FOG: CBS domain [General function prediction only]; Region: COG0517
399726004204	Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780
399726004205	pyruvate phosphate dikinase; Provisional; Region: PRK09279
399726004206	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
399726004207	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586
399726004208	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155
399726004209	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
399726004210	ribonuclease R; Region: RNase_R; TIGR02063
399726004211	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
399726004212	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
399726004213	RNB domain; Region: RNB; pfam00773
399726004214	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471
399726004215	RNA binding site [nucleotide binding]; other site
399726004216	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
399726004217	SmpB-tmRNA interface; other site
399726004218	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
399726004219	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726004220	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004221	Walker A/P-loop; other site
399726004222	ATP binding site [chemical binding]; other site
399726004223	Q-loop/lid; other site
399726004224	ABC transporter signature motif; other site
399726004225	Walker B; other site
399726004226	D-loop; other site
399726004227	H-loop/switch region; other site
399726004228	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
399726004229	non-specific DNA binding site [nucleotide binding]; other site
399726004230	salt bridge; other site
399726004231	sequence-specific DNA binding site [nucleotide binding]; other site
399726004232	FtsX-like permease family; Region: FtsX; cl15850
399726004233	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
399726004234	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
399726004235	Walker A/P-loop; other site
399726004236	ATP binding site [chemical binding]; other site
399726004237	Q-loop/lid; other site
399726004238	ABC transporter signature motif; other site
399726004239	Walker B; other site
399726004240	D-loop; other site
399726004241	H-loop/switch region; other site
399726004242	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
399726004243	non-specific DNA binding site [nucleotide binding]; other site
399726004244	salt bridge; other site
399726004245	sequence-specific DNA binding site [nucleotide binding]; other site
399726004246	nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064
399726004247	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004248	FeS/SAM binding site; other site
399726004249	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
399726004250	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
399726004251	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726004252	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004253	Walker A/P-loop; other site
399726004254	ATP binding site [chemical binding]; other site
399726004255	Q-loop/lid; other site
399726004256	ABC transporter signature motif; other site
399726004257	Walker B; other site
399726004258	D-loop; other site
399726004259	H-loop/switch region; other site
399726004260	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726004261	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
399726004262	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
399726004263	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004264	FeS/SAM binding site; other site
399726004265	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
399726004266	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726004267	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004268	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
399726004269	Walker A/P-loop; other site
399726004270	ATP binding site [chemical binding]; other site
399726004271	Q-loop/lid; other site
399726004272	ABC transporter signature motif; other site
399726004273	Walker B; other site
399726004274	D-loop; other site
399726004275	H-loop/switch region; other site
399726004276	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
399726004277	The MRP (Mutidrug Resistance Protein)-like transporters are involved in drug, peptide, and lipid export.  They belong to the subfamily C of the ATP-binding cassette (ABC) superfamily of transport proteins.  The ABCC subfamily contains transporters with a...; Region: ABCC_MRP_Like; cd03228
399726004278	Walker A/P-loop; other site
399726004279	ATP binding site [chemical binding]; other site
399726004280	Q-loop/lid; other site
399726004281	ABC transporter signature motif; other site
399726004282	Walker B; other site
399726004283	D-loop; other site
399726004284	H-loop/switch region; other site
399726004285	Protein of unknown function (DUF969); Region: DUF969; cl01573
399726004286	Protein of unknown function (DUF979); Region: DUF979; cl01572
399726004287	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
399726004288	putative substrate binding pocket [chemical binding]; other site
399726004289	AC domain interface; other site
399726004290	catalytic triad [active]
399726004291	AB domain interface; other site
399726004292	interchain disulfide; other site
399726004293	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
399726004294	ligand binding site [chemical binding]; other site
399726004295	flexible hinge region; other site
399726004296	Helix-turn-helix domains; Region: HTH; cl00088
399726004297	intracellular protease, PfpI family; Region: PfpI; TIGR01382
399726004298	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
399726004299	proposed catalytic triad [active]
399726004300	conserved cys residue [active]
399726004301	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
399726004302	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
399726004303	active site
399726004304	FMN binding site [chemical binding]; other site
399726004305	substrate binding site [chemical binding]; other site
399726004306	putative catalytic residue [active]
399726004307	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004308	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726004309	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
399726004310	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
399726004311	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354
399726004312	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
399726004313	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
399726004314	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004315	FeS/SAM binding site; other site
399726004316	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
399726004317	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
399726004318	MoaE interaction surface [polypeptide binding]; other site
399726004319	MoeB interaction surface [polypeptide binding]; other site
399726004320	thiocarboxylated glycine; other site
399726004321	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
399726004322	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
399726004323	ATP binding site [chemical binding]; other site
399726004324	substrate interface [chemical binding]; other site
399726004325	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494
399726004326	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
399726004327	Walker A motif; other site
399726004328	Putative Fe-S cluster; Region: FeS; pfam04060
399726004329	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
399726004330	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
399726004331	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726004332	dimer interface [polypeptide binding]; other site
399726004333	conserved gate region; other site
399726004334	putative PBP binding loops; other site
399726004335	ABC-ATPase subunit interface; other site
399726004336	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
399726004337	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726004338	Walker A/P-loop; other site
399726004339	ATP binding site [chemical binding]; other site
399726004340	Q-loop/lid; other site
399726004341	ABC transporter signature motif; other site
399726004342	Walker B; other site
399726004343	D-loop; other site
399726004344	H-loop/switch region; other site
399726004345	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
399726004346	MPT binding site; other site
399726004347	trimer interface [polypeptide binding]; other site
399726004348	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
399726004349	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
399726004350	dimer interface [polypeptide binding]; other site
399726004351	putative functional site; other site
399726004352	putative MPT binding site; other site
399726004353	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
399726004354	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
399726004355	dimer interface [polypeptide binding]; other site
399726004356	putative functional site; other site
399726004357	putative MPT binding site; other site
399726004358	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726004359	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
399726004360	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004361	FeS/SAM binding site; other site
399726004362	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
399726004363	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
399726004364	trimer interface [polypeptide binding]; other site
399726004365	dimer interface [polypeptide binding]; other site
399726004366	putative active site [active]
399726004367	MOSC domain; Region: MOSC; pfam03473
399726004368	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726004369	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726004370	dimer interface [polypeptide binding]; other site
399726004371	conserved gate region; other site
399726004372	putative PBP binding loops; other site
399726004373	ABC-ATPase subunit interface; other site
399726004374	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004375	Walker A/P-loop; other site
399726004376	ATP binding site [chemical binding]; other site
399726004377	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004378	ABC transporter signature motif; other site
399726004379	Walker B; other site
399726004380	D-loop; other site
399726004381	MOSC domain; Region: MOSC; pfam03473
399726004382	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
399726004383	Helix-turn-helix domains; Region: HTH; cl00088
399726004384	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
399726004385	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
399726004386	4Fe-4S binding domain; Region: Fer4; cl02805
399726004387	Peptidase family M48; Region: Peptidase_M48; cl12018
399726004388	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
399726004389	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
399726004390	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004391	FeS/SAM binding site; other site
399726004392	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
399726004393	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
399726004394	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
399726004395	active site
399726004396	catalytic site [active]
399726004397	metal binding site [ion binding]; metal-binding site
399726004398	dimer interface [polypeptide binding]; other site
399726004399	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726004400	Major Facilitator Superfamily; Region: MFS_1; pfam07690
399726004401	putative substrate translocation pore; other site
399726004402	Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908
399726004403	putative ADP-ribose binding site [chemical binding]; other site
399726004404	putative active site [active]
399726004405	Bacitracin resistance protein BacA; Region: BacA; cl00858
399726004406	Small, acid-soluble spore protein I; Region: SSPI; cl07940
399726004407	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
399726004408	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
399726004409	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726004410	NADPH-dependent FMN reductase; Region: FMN_red; cl00438
399726004411	Low molecular weight phosphatase family; Region: LMWPc; cd00115
399726004412	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
399726004413	active site
399726004414	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
399726004415	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004416	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
399726004417	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
399726004418	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
399726004419	Putative cyclase; Region: Cyclase; cl00814
399726004420	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
399726004421	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
399726004422	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
399726004423	putative L-serine binding site [chemical binding]; other site
399726004424	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
399726004425	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
399726004426	oligoendopeptidase F; Region: pepF; TIGR00181
399726004427	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
399726004428	active site
399726004429	Zn binding site [ion binding]; other site
399726004430	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
399726004431	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
399726004432	active site
399726004433	dimer interface [polypeptide binding]; other site
399726004434	metal binding site [ion binding]; metal-binding site
399726004435	prephenate dehydratase; Provisional; Region: PRK11898
399726004436	Prephenate dehydratase; Region: PDT; pfam00800
399726004437	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
399726004438	putative L-Phe binding site [chemical binding]; other site
399726004439	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
399726004440	NeuB family; Region: NeuB; cl00496
399726004441	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004442	Prephenate dehydrogenase; Region: PDH; pfam02153
399726004443	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
399726004444	3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356
399726004445	hinge; other site
399726004446	active site
399726004447	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
399726004448	Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713
399726004449	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726004450	putative peptidoglycan binding site; other site
399726004451	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
399726004452	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726004453	putative peptidoglycan binding site; other site
399726004454	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
399726004455	Predicted membrane protein [Function unknown]; Region: COG2119
399726004456	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
399726004457	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
399726004458	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
399726004459	Helix-turn-helix domains; Region: HTH; cl00088
399726004460	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
399726004461	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726004462	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726004463	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
399726004464	active site
399726004465	trimer interface [polypeptide binding]; other site
399726004466	allosteric site; other site
399726004467	active site lid [active]
399726004468	hexamer (dimer of trimers) interface [polypeptide binding]; other site
399726004469	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
399726004470	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
399726004471	catalytic residues [active]
399726004472	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
399726004473	catalytic residues [active]
399726004474	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
399726004475	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
399726004476	homodimer interface [polypeptide binding]; other site
399726004477	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726004478	catalytic residue [active]
399726004479	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
399726004480	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
399726004481	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
399726004482	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
399726004483	catalytic loop [active]
399726004484	iron binding site [ion binding]; other site
399726004485	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
399726004486	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004487	Walker A/P-loop; other site
399726004488	ATP binding site [chemical binding]; other site
399726004489	Q-loop/lid; other site
399726004490	ABC transporter signature motif; other site
399726004491	Walker B; other site
399726004492	D-loop; other site
399726004493	H-loop/switch region; other site
399726004494	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726004495	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726004496	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726004497	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726004498	Stage II sporulation protein; Region: SpoIID; pfam08486
399726004499	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
399726004500	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
399726004501	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
399726004502	HflX GTPase family; Region: HflX; cd01878
399726004503	G1 box; other site
399726004504	GTP/Mg2+ binding site [chemical binding]; other site
399726004505	Switch I region; other site
399726004506	G2 box; other site
399726004507	G3 box; other site
399726004508	Switch II region; other site
399726004509	G4 box; other site
399726004510	G5 box; other site
399726004511	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
399726004512	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
399726004513	active site
399726004514	Ap6A binding site [chemical binding]; other site
399726004515	nudix motif; other site
399726004516	metal binding site [ion binding]; metal-binding site
399726004517	uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257
399726004518	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
399726004519	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
399726004520	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004521	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
399726004522	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
399726004523	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
399726004524	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
399726004525	dimer interface [polypeptide binding]; other site
399726004526	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726004527	catalytic residue [active]
399726004528	Transcriptional regulator; Region: Transcrip_reg; cl00361
399726004529	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
399726004530	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529
399726004531	active site
399726004532	putative DNA-binding cleft [nucleotide binding]; other site
399726004533	dimer interface [polypeptide binding]; other site
399726004534	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
399726004535	RuvA N terminal domain; Region: RuvA_N; pfam01330
399726004536	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
399726004537	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
399726004538	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726004539	Walker A motif; other site
399726004540	ATP binding site [chemical binding]; other site
399726004541	Walker B motif; other site
399726004542	arginine finger; other site
399726004543	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
399726004544	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
399726004545	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
399726004546	Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523
399726004547	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
399726004548	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
399726004549	Preprotein translocase subunit; Region: YajC; cl00806
399726004550	Protein of unknown function (DUF3792); Region: DUF3792; cl14821
399726004551	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
399726004552	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004553	FeS/SAM binding site; other site
399726004554	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
399726004555	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
399726004556	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
399726004557	trimer interface [polypeptide binding]; other site
399726004558	putative metal binding site [ion binding]; other site
399726004559	bifunctional preprotein translocase subunit SecD/SecF; Reviewed; Region: PRK13024
399726004560	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
399726004561	Protein export membrane protein; Region: SecD_SecF; cl14618
399726004562	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
399726004563	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
399726004564	Protein export membrane protein; Region: SecD_SecF; cl14618
399726004565	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
399726004566	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
399726004567	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120
399726004568	active site
399726004569	ATP binding site [chemical binding]; other site
399726004570	substrate binding site [chemical binding]; other site
399726004571	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
399726004572	DHH family; Region: DHH; pfam01368
399726004573	DHHA1 domain; Region: DHHA1; pfam02272
399726004574	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
399726004575	Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins [Nucleotide transport and metabolism]; Region: Apt; COG0503
399726004576	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726004577	active site
399726004578	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
399726004579	putative active site [active]
399726004580	dimerization interface [polypeptide binding]; other site
399726004581	putative tRNAtyr binding site [nucleotide binding]; other site
399726004582	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726004583	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
399726004584	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
399726004585	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773
399726004586	dimer interface [polypeptide binding]; other site
399726004587	motif 1; other site
399726004588	active site
399726004589	motif 2; other site
399726004590	motif 3; other site
399726004591	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
399726004592	anticodon binding site; other site
399726004593	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
399726004594	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
399726004595	dimer interface [polypeptide binding]; other site
399726004596	anticodon binding site; other site
399726004597	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
399726004598	homodimer interface [polypeptide binding]; other site
399726004599	motif 1; other site
399726004600	active site
399726004601	motif 2; other site
399726004602	GAD domain; Region: GAD; pfam02938
399726004603	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777
399726004604	motif 3; other site
399726004605	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
399726004606	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
399726004607	putative ATP binding site [chemical binding]; other site
399726004608	putative substrate interface [chemical binding]; other site
399726004609	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
399726004610	putative homotetramer interface [polypeptide binding]; other site
399726004611	putative homodimer interface [polypeptide binding]; other site
399726004612	putative allosteric switch controlling residues; other site
399726004613	putative metal binding site [ion binding]; other site
399726004614	putative homodimer-homodimer interface [polypeptide binding]; other site
399726004615	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
399726004616	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
399726004617	catalytic residues [active]
399726004618	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
399726004619	catalytic residues [active]
399726004620	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
399726004621	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004622	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
399726004623	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
399726004624	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726004625	catalytic residue [active]
399726004626	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
399726004627	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
399726004628	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
399726004629	B12 binding site [chemical binding]; other site
399726004630	cobalt ligand [ion binding]; other site
399726004631	MutL protein; Region: MutL; pfam13941
399726004632	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
399726004633	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
399726004634	dimer interface [polypeptide binding]; other site
399726004635	active site
399726004636	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
399726004637	substrate binding site [chemical binding]; other site
399726004638	catalytic residue [active]
399726004639	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
399726004640	Helix-turn-helix domains; Region: HTH; cl00088
399726004641	Rrf2 family protein; Region: rrf2_super; TIGR00738
399726004642	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
399726004643	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
399726004644	Ligand Binding Site [chemical binding]; other site
399726004645	pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465
399726004646	Domain of unknown function DUF20; Region: UPF0118; pfam01594
399726004647	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
399726004648	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673
399726004649	motif 1; other site
399726004650	active site
399726004651	motif 2; other site
399726004652	motif 3; other site
399726004653	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268
399726004654	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
399726004655	DHHA1 domain; Region: DHHA1; pfam02272
399726004656	Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857
399726004657	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination.  HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243
399726004658	Protein of unknown function (DUF1292); Region: DUF1292; cl01608
399726004659	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
399726004660	metal binding site 2 [ion binding]; metal-binding site
399726004661	putative DNA binding helix; other site
399726004662	metal binding site 1 [ion binding]; metal-binding site
399726004663	dimer interface [polypeptide binding]; other site
399726004664	structural Zn2+ binding site [ion binding]; other site
399726004665	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
399726004666	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726004667	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
399726004668	Protein of unknown function (DUF964); Region: DUF964; cl01483
399726004669	QueT transporter; Region: QueT; cl01932
399726004670	YceG-like family; Region: YceG; pfam02618
399726004671	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
399726004672	dimerization interface [polypeptide binding]; other site
399726004673	O-methyltransferase; Region: Methyltransf_3; pfam01596
399726004674	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726004675	S-adenosylmethionine binding site [chemical binding]; other site
399726004676	putative protease; Provisional; Region: PRK15452
399726004677	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
399726004678	Peptidase family U32; Region: Peptidase_U32; cl03113
399726004679	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
399726004680	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
399726004681	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726004682	sporulation sigma factor SigK; Reviewed; Region: PRK05803
399726004683	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726004684	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726004685	DNA binding residues [nucleotide binding]
399726004686	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
399726004687	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726004688	active site
399726004689	motif I; other site
399726004690	motif II; other site
399726004691	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
399726004692	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
399726004693	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
399726004694	shikimate binding site; other site
399726004695	NAD(P) binding site [chemical binding]; other site
399726004696	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
399726004697	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
399726004698	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
399726004699	Walker A motif; other site
399726004700	ATP binding site [chemical binding]; other site
399726004701	Walker B motif; other site
399726004702	pilus retraction protein PilT; Region: pilT_fam; TIGR01420
399726004703	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
399726004704	Walker A motif; other site
399726004705	ATP binding site [chemical binding]; other site
399726004706	Walker B motif; other site
399726004707	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
399726004708	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
399726004709	Type II secretion system (T2SS), protein F; Region: T2SF; cl00906
399726004710	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
399726004711	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
399726004712	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
399726004713	general secretion pathway protein I; Region: gspI; TIGR01707
399726004714	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
399726004715	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
399726004716	Late competence development protein ComFB; Region: ComFB; pfam10719
399726004717	Cell division protein FtsA; Region: FtsA; cl11496
399726004718	Cell division protein FtsA; Region: FtsA; cl11496
399726004719	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
399726004720	Pilus assembly protein, PilO; Region: PilO; cl01234
399726004721	shikimate kinase; Provisional; Region: PRK13947
399726004722	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
399726004723	ADP binding site [chemical binding]; other site
399726004724	magnesium binding site [ion binding]; other site
399726004725	putative shikimate binding site; other site
399726004726	AP endonuclease family 2; Region: AP2Ec; smart00518
399726004727	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
399726004728	AP (apurinic/apyrimidinic) site pocket; other site
399726004729	DNA interaction; other site
399726004730	Metal-binding active site; metal-binding site
399726004731	gamma-glutamyl kinase; Provisional; Region: PRK05429
399726004732	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
399726004733	nucleotide binding site [chemical binding]; other site
399726004734	homotetrameric interface [polypeptide binding]; other site
399726004735	putative phosphate binding site [ion binding]; other site
399726004736	putative allosteric binding site; other site
399726004737	PUA domain; Region: PUA; cl00607
399726004738	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
399726004739	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
399726004740	putative catalytic cysteine [active]
399726004741	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
399726004742	trimer interface [polypeptide binding]; other site
399726004743	active site
399726004744	dimer interface [polypeptide binding]; other site
399726004745	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
399726004746	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
399726004747	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
399726004748	active site
399726004749	elongation factor P; Validated; Region: PRK00529
399726004750	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
399726004751	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
399726004752	RNA binding site [nucleotide binding]; other site
399726004753	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
399726004754	RNA binding site [nucleotide binding]; other site
399726004755	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
399726004756	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726004757	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
399726004758	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
399726004759	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
399726004760	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771
399726004761	stage III sporulation protein AF; Region: spore_III_AF; TIGR02896
399726004762	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
399726004763	Arginase family; Region: Arginase; cl00306
399726004764	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
399726004765	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
399726004766	Asp23 family; Region: Asp23; cl00574
399726004767	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
399726004768	putative RNA binding site [nucleotide binding]; other site
399726004769	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14176
399726004770	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
399726004771	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
399726004772	homodimer interface [polypeptide binding]; other site
399726004773	NADP binding site [chemical binding]; other site
399726004774	substrate binding site [chemical binding]; other site
399726004775	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
399726004776	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
399726004777	generic binding surface II; other site
399726004778	generic binding surface I; other site
399726004779	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306
399726004780	Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750
399726004781	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
399726004782	substrate binding pocket [chemical binding]; other site
399726004783	chain length determination region; other site
399726004784	substrate-Mg2+ binding site; other site
399726004785	catalytic residues [active]
399726004786	aspartate-rich region 1; other site
399726004787	active site lid residues [active]
399726004788	aspartate-rich region 2; other site
399726004789	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
399726004790	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
399726004791	TPP-binding site; other site
399726004792	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
399726004793	PYR/PP interface [polypeptide binding]; other site
399726004794	dimer interface [polypeptide binding]; other site
399726004795	TPP binding site [chemical binding]; other site
399726004796	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
399726004797	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
399726004798	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
399726004799	RNA binding surface [nucleotide binding]; other site
399726004800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
399726004801	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
399726004802	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
399726004803	arginine repressor; Provisional; Region: argR; PRK00441
399726004804	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
399726004805	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
399726004806	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
399726004807	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
399726004808	Walker A/P-loop; other site
399726004809	ATP binding site [chemical binding]; other site
399726004810	Q-loop/lid; other site
399726004811	RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241
399726004812	ABC transporter signature motif; other site
399726004813	Walker B; other site
399726004814	D-loop; other site
399726004815	H-loop/switch region; other site
399726004816	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
399726004817	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
399726004818	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
399726004819	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
399726004820	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726004821	active site
399726004822	phosphorylation site [posttranslational modification]
399726004823	intermolecular recognition site; other site
399726004824	dimerization interface [polypeptide binding]; other site
399726004825	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
399726004826	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825
399726004827	Thiamine pyrophosphokinase; Region: TPK; cl08415
399726004828	active site
399726004829	Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555
399726004830	Protein of unknown function (DUF3186); Region: DUF3186; pfam11382
399726004831	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
399726004832	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
399726004833	Ligand binding site; other site
399726004834	Putative Catalytic site; other site
399726004835	DXD motif; other site
399726004836	Protein of unknown function (DUF3866); Region: DUF3866; pfam12982
399726004837	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
399726004838	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
399726004839	dimer interface [polypeptide binding]; other site
399726004840	ADP-ribose binding site [chemical binding]; other site
399726004841	active site
399726004842	nudix motif; other site
399726004843	metal binding site [ion binding]; metal-binding site
399726004844	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
399726004845	PHP-associated; Region: PHP_C; pfam13263
399726004846	Integral membrane protein DUF95; Region: DUF95; cl00572
399726004847	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
399726004848	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
399726004849	DNA binding site [nucleotide binding]
399726004850	active site
399726004851	Int/Topo IB signature motif; other site
399726004852	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
399726004853	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726004854	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
399726004855	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
399726004856	anti sigma factor interaction site; other site
399726004857	regulatory phosphorylation site [posttranslational modification]; other site
399726004858	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
399726004859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726004860	ATP binding site [chemical binding]; other site
399726004861	Mg2+ binding site [ion binding]; other site
399726004862	G-X-G motif; other site
399726004863	RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885
399726004864	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726004865	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
399726004866	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726004867	DNA binding residues [nucleotide binding]
399726004868	Dodecin; Region: Dodecin; cl01328
399726004869	SpoVA protein; Region: SpoVA; cl04298
399726004870	stage V sporulation protein AD; Validated; Region: PRK08304
399726004871	stage V sporulation protein AD; Provisional; Region: PRK12404
399726004872	SpoVA protein; Region: SpoVA; cl04298
399726004873	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
399726004874	active site
399726004875	NTP binding site [chemical binding]; other site
399726004876	metal binding triad [ion binding]; metal-binding site
399726004877	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
399726004878	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
399726004879	active site
399726004880	putative substrate binding region [chemical binding]; other site
399726004881	ScpA/B protein; Region: ScpA_ScpB; cl00598
399726004882	Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612
399726004883	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
399726004884	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
399726004885	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
399726004886	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
399726004887	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
399726004888	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
399726004889	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
399726004890	dimer interface [polypeptide binding]; other site
399726004891	active site residues [active]
399726004892	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
399726004893	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
399726004894	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726004895	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
399726004896	hypothetical protein; Provisional; Region: PRK05802
399726004897	FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192
399726004898	FAD binding pocket [chemical binding]; other site
399726004899	FAD binding motif [chemical binding]; other site
399726004900	phosphate binding motif [ion binding]; other site
399726004901	beta-alpha-beta structure motif; other site
399726004902	NAD binding pocket [chemical binding]; other site
399726004903	Iron coordination center [ion binding]; other site
399726004904	Glucose inhibited division protein A; Region: GIDA; pfam01134
399726004905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004907	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
399726004908	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
399726004909	RNA binding surface [nucleotide binding]; other site
399726004910	Pseudouridine synthases  are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870
399726004911	active site
399726004912	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
399726004913	spermidine synthase; Provisional; Region: PRK00811
399726004914	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726004915	S-adenosylmethionine binding site [chemical binding]; other site
399726004916	Arginase family; Region: Arginase; cl00306
399726004917	oxaloacetate decarboxylase; Provisional; Region: PRK12331
399726004918	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
399726004919	active site
399726004920	catalytic residues [active]
399726004921	metal binding site [ion binding]; metal-binding site
399726004922	homodimer binding site [polypeptide binding]; other site
399726004923	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726004924	putative peptidoglycan binding site; other site
399726004925	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726004926	putative peptidoglycan binding site; other site
399726004927	Survival protein SurE; Region: SurE; cl00448
399726004928	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
399726004929	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
399726004930	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
399726004931	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
399726004932	dimer interface [polypeptide binding]; other site
399726004933	PYR/PP interface [polypeptide binding]; other site
399726004934	TPP binding site [chemical binding]; other site
399726004935	substrate binding site [chemical binding]; other site
399726004936	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
399726004937	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
399726004938	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
399726004939	TPP-binding site [chemical binding]; other site
399726004940	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
399726004941	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
399726004942	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
399726004943	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
399726004944	putative active site [active]
399726004945	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
399726004946	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
399726004947	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
399726004948	NAD(P) binding site [chemical binding]; other site
399726004949	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
399726004950	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357
399726004951	transmembrane helices; other site
399726004952	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
399726004953	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
399726004954	LamB/YcsF family; Region: LamB_YcsF; cl00664
399726004955	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
399726004956	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
399726004957	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
399726004958	Protein of unknown function (DUF1445); Region: DUF1445; cl01790
399726004959	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004960	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
399726004961	catalytic core [active]
399726004962	flavoprotein, HI0933 family; Region: TIGR00275
399726004963	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004964	cytidylate kinase; Provisional; Region: cmk; PRK00023
399726004965	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
399726004966	CMP-binding site; other site
399726004967	The sites determining sugar specificity; other site
399726004968	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
399726004969	putative acyl-acceptor binding pocket; other site
399726004970	LytB protein; Region: LYTB; cl00507
399726004971	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
399726004972	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
399726004973	RNA binding site [nucleotide binding]; other site
399726004974	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
399726004975	RNA binding site [nucleotide binding]; other site
399726004976	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688
399726004977	RNA binding site [nucleotide binding]; other site
399726004978	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
399726004979	RNA binding site [nucleotide binding]; other site
399726004980	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
399726004981	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
399726004982	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
399726004983	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726004984	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
399726004985	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
399726004986	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726004987	FeS/SAM binding site; other site
399726004988	TRAM domain; Region: TRAM; cl01282
399726004989	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
399726004990	MutS domain I; Region: MutS_I; pfam01624
399726004991	MutS domain II; Region: MutS_II; pfam05188
399726004992	MutS family domain IV; Region: MutS_IV; pfam05190
399726004993	MutS1 homolog in eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch.  Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284
399726004994	Walker A/P-loop; other site
399726004995	ATP binding site [chemical binding]; other site
399726004996	Q-loop/lid; other site
399726004997	ABC transporter signature motif; other site
399726004998	Walker B; other site
399726004999	D-loop; other site
399726005000	H-loop/switch region; other site
399726005001	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
399726005002	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
399726005003	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
399726005004	ATP binding site [chemical binding]; other site
399726005005	MutL C terminal dimerisation domain; Region: MutL_C; cl07336
399726005006	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005007	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
399726005008	Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716
399726005009	Sm1 motif; other site
399726005010	intra - hexamer interaction site; other site
399726005011	inter - hexamer interaction site [polypeptide binding]; other site
399726005012	nucleotide binding pocket [chemical binding]; other site
399726005013	Sm2 motif; other site
399726005014	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726005015	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
399726005016	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
399726005017	RNA/DNA hybrid binding site [nucleotide binding]; other site
399726005018	active site
399726005019	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
399726005020	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
399726005021	DNA binding site [nucleotide binding]
399726005022	Int/Topo IB signature motif; other site
399726005023	active site
399726005024	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
399726005025	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
399726005026	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726005027	catalytic residue [active]
399726005028	stage V sporulation protein K; Region: spore_V_K; TIGR02881
399726005029	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726005030	Walker A motif; other site
399726005031	ATP binding site [chemical binding]; other site
399726005032	Walker B motif; other site
399726005033	arginine finger; other site
399726005034	adenylosuccinate lyase; Region: purB; TIGR00928
399726005035	Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302
399726005036	tetramer interface [polypeptide binding]; other site
399726005037	active site
399726005038	aspartate aminotransferase; Provisional; Region: PRK05764
399726005039	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
399726005040	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726005041	homodimer interface [polypeptide binding]; other site
399726005042	catalytic residue [active]
399726005043	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
399726005044	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
399726005045	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
399726005046	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
399726005047	putative active site [active]
399726005048	metal binding site [ion binding]; metal-binding site
399726005049	homodimer binding site [polypeptide binding]; other site
399726005050	phosphodiesterase; Provisional; Region: PRK12704
399726005051	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
399726005052	RecX family; Region: RecX; cl00936
399726005053	recombinase A; Provisional; Region: recA; PRK09354
399726005054	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
399726005055	hexamer interface [polypeptide binding]; other site
399726005056	Walker A motif; other site
399726005057	ATP binding site [chemical binding]; other site
399726005058	Walker B motif; other site
399726005059	competence damage-inducible protein A; Provisional; Region: PRK00549
399726005060	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
399726005061	putative MPT binding site; other site
399726005062	Competence-damaged protein; Region: CinA; cl00666
399726005063	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
399726005064	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
399726005065	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
399726005066	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726005067	FeS/SAM binding site; other site
399726005068	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
399726005069	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005070	Ftsk gamma domain; Region: Ftsk_gamma; cl09645
399726005071	YlzJ-like protein; Region: YlzJ; pfam14035
399726005072	Clp protease; Region: CLP_protease; pfam00574
399726005073	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
399726005074	active site
399726005075	aspartate kinase I; Reviewed; Region: PRK08210
399726005076	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
399726005077	nucleotide binding site [chemical binding]; other site
399726005078	substrate binding site [chemical binding]; other site
399726005079	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
399726005080	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937
399726005081	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
399726005082	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
399726005083	trimer interface [polypeptide binding]; other site
399726005084	active site
399726005085	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
399726005086	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
399726005087	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
399726005088	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
399726005089	NodB motif; other site
399726005090	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
399726005091	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
399726005092	RNase E interface [polypeptide binding]; other site
399726005093	trimer interface [polypeptide binding]; other site
399726005094	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
399726005095	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
399726005096	RNase E interface [polypeptide binding]; other site
399726005097	trimer interface [polypeptide binding]; other site
399726005098	active site
399726005099	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
399726005100	putative nucleic acid binding region [nucleotide binding]; other site
399726005101	G-X-X-G motif; other site
399726005102	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
399726005103	RNA binding site [nucleotide binding]; other site
399726005104	domain interface; other site
399726005105	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
399726005106	16S/18S rRNA binding site [nucleotide binding]; other site
399726005107	S13e-L30e interaction site [polypeptide binding]; other site
399726005108	25S rRNA binding site [nucleotide binding]; other site
399726005109	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
399726005110	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
399726005111	active site
399726005112	Riboflavin kinase; Region: Flavokinase; cl03312
399726005113	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
399726005114	PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573
399726005115	RNA binding site [nucleotide binding]; other site
399726005116	active site
399726005117	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
399726005118	DHH family; Region: DHH; pfam01368
399726005119	DHHA1 domain; Region: DHHA1; pfam02272
399726005120	Ribosome-binding factor A; Region: RBFA; cl00542
399726005121	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
399726005122	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
399726005123	translation initiation factor IF-2; Region: IF-2; TIGR00487
399726005124	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
399726005125	G1 box; other site
399726005126	putative GEF interaction site [polypeptide binding]; other site
399726005127	GTP/Mg2+ binding site [chemical binding]; other site
399726005128	Switch I region; other site
399726005129	G2 box; other site
399726005130	G3 box; other site
399726005131	Switch II region; other site
399726005132	G4 box; other site
399726005133	G5 box; other site
399726005134	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
399726005135	Translation-initiation factor 2; Region: IF-2; pfam11987
399726005136	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
399726005137	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
399726005138	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
399726005139	putative RNA binding cleft [nucleotide binding]; other site
399726005140	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
399726005141	NusA N-terminal domain; Region: NusA_N; pfam08529
399726005142	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
399726005143	RNA binding site [nucleotide binding]; other site
399726005144	homodimer interface [polypeptide binding]; other site
399726005145	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
399726005146	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
399726005147	G-X-X-G motif; other site
399726005148	ribosome maturation protein RimP; Reviewed; Region: PRK00092
399726005149	The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation.  Members of...; Region: Sm_like; cl00259
399726005150	YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold.  The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734
399726005151	Sm1 motif; other site
399726005152	predicted subunit interaction site [polypeptide binding]; other site
399726005153	RNA binding pocket [nucleotide binding]; other site
399726005154	Sm2 motif; other site
399726005155	DNA polymerase III PolC; Validated; Region: polC; PRK00448
399726005156	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
399726005157	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
399726005158	generic binding surface I; other site
399726005159	generic binding surface II; other site
399726005160	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
399726005161	active site
399726005162	substrate binding site [chemical binding]; other site
399726005163	catalytic site [active]
399726005164	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
399726005165	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
399726005166	Ligand binding site; other site
399726005167	Putative Catalytic site; other site
399726005168	DXD motif; other site
399726005169	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
399726005170	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
399726005171	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
399726005172	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
399726005173	active site
399726005174	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
399726005175	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
399726005176	putative substrate binding region [chemical binding]; other site
399726005177	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
399726005178	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
399726005179	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
399726005180	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
399726005181	Cytidylyltransferase family; Region: CTP_transf_1; cl00347
399726005182	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
399726005183	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
399726005184	catalytic residue [active]
399726005185	putative FPP diphosphate  binding site; other site
399726005186	putative FPP binding hydrophobic cleft; other site
399726005187	dimer interface [polypeptide binding]; other site
399726005188	putative IPP diphosphate binding site; other site
399726005189	ribosome recycling factor; Reviewed; Region: frr; PRK00083
399726005190	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520
399726005191	hinge region; other site
399726005192	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
399726005193	putative nucleotide binding site [chemical binding]; other site
399726005194	uridine monophosphate binding site [chemical binding]; other site
399726005195	homohexameric interface [polypeptide binding]; other site
399726005196	elongation factor Ts; Reviewed; Region: tsf; PRK12332
399726005197	Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153
399726005198	Elongation factor TS; Region: EF_TS; pfam00889
399726005199	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
399726005200	rRNA interaction site [nucleotide binding]; other site
399726005201	S8 interaction site; other site
399726005202	putative laminin-1 binding site; other site
399726005203	Protein of unknown function (DUF342); Region: DUF342; pfam03961
399726005204	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
399726005205	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726005206	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
399726005207	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726005208	DNA binding residues [nucleotide binding]
399726005209	CheD chemotactic sensory transduction; Region: CheD; cl00810
399726005210	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
399726005211	Chemotaxis phosphatase CheX; Region: CheX; cl15816
399726005212	Chemotaxis phosphatase CheX; Region: CheX; cl15816
399726005213	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
399726005214	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
399726005215	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
399726005216	putative binding surface; other site
399726005217	active site
399726005218	P2 response regulator binding domain; Region: P2; pfam07194
399726005219	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
399726005220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726005221	ATP binding site [chemical binding]; other site
399726005222	Mg2+ binding site [ion binding]; other site
399726005223	G-X-G motif; other site
399726005224	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
399726005225	CheB methylesterase; Region: CheB_methylest; pfam01339
399726005226	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
399726005227	Flagellar protein YcgR; Region: YcgR_2; pfam12945
399726005228	PilZ domain; Region: PilZ; cl01260
399726005229	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005230	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
399726005231	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
399726005232	Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419
399726005233	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005234	flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980
399726005235	FHIPEP family; Region: FHIPEP; pfam00771
399726005236	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
399726005237	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
399726005238	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
399726005239	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
399726005240	FliP family; Region: FliP; cl00593
399726005241	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
399726005242	Response regulator receiver domain; Region: Response_reg; pfam00072
399726005243	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726005244	active site
399726005245	phosphorylation site [posttranslational modification]
399726005246	intermolecular recognition site; other site
399726005247	dimerization interface [polypeptide binding]; other site
399726005248	flagellar motor switch protein; Validated; Region: PRK08119
399726005249	Chemotaxis phosphatase CheX; Region: CheX; cl15816
399726005250	Chemotaxis phosphatase CheX; Region: CheX; cl15816
399726005251	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
399726005252	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
399726005253	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
399726005254	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
399726005255	Flagellar basal body-associated protein FliL; Region: FliL; cl00681
399726005256	Flagellar protein (FlbD); Region: FlbD; cl00683
399726005257	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
399726005258	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
399726005259	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
399726005260	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
399726005261	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
399726005262	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
399726005263	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
399726005264	Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269
399726005265	MgtE intracellular N domain; Region: MgtE_N; cl15244
399726005266	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
399726005267	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
399726005268	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
399726005269	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
399726005270	Walker A motif/ATP binding site; other site
399726005271	Walker B motif; other site
399726005272	Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317
399726005273	Flagellar assembly protein FliH; Region: FliH; pfam02108
399726005274	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
399726005275	MgtE intracellular N domain; Region: MgtE_N; cl15244
399726005276	FliG C-terminal domain; Region: FliG_C; pfam01706
399726005277	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
399726005278	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
399726005279	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
399726005280	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
399726005281	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
399726005282	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
399726005283	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
399726005284	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
399726005285	Flagella basal body rod protein; Region: Flg_bb_rod; cl15793
399726005286	transcriptional repressor CodY; Validated; Region: PRK04158
399726005287	CodY GAF-like domain; Region: CodY; pfam06018
399726005288	Helix-turn-helix domains; Region: HTH; cl00088
399726005289	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
399726005290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726005291	Walker A motif; other site
399726005292	ATP binding site [chemical binding]; other site
399726005293	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005294	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
399726005295	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
399726005296	active site
399726005297	HslU subunit interaction site [polypeptide binding]; other site
399726005298	DNA topoisomerase I; Validated; Region: PRK05582
399726005299	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
399726005300	active site
399726005301	interdomain interaction site; other site
399726005302	putative metal-binding site [ion binding]; other site
399726005303	nucleotide binding site [chemical binding]; other site
399726005304	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
399726005305	domain I; other site
399726005306	DNA binding groove [nucleotide binding]
399726005307	phosphate binding site [ion binding]; other site
399726005308	domain II; other site
399726005309	domain III; other site
399726005310	nucleotide binding site [chemical binding]; other site
399726005311	catalytic site [active]
399726005312	domain IV; other site
399726005313	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
399726005314	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
399726005315	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
399726005316	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
399726005317	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
399726005318	Helix-turn-helix domains; Region: HTH; cl00088
399726005319	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
399726005320	RNA/DNA hybrid binding site [nucleotide binding]; other site
399726005321	active site
399726005322	Restriction endonuclease; Region: Mrr_cat; cl00516
399726005323	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
399726005324	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
399726005325	active site
399726005326	HIGH motif; other site
399726005327	dimer interface [polypeptide binding]; other site
399726005328	KMSKS motif; other site
399726005329	Uncharacterized conserved protein [Function unknown]; Region: COG1284
399726005330	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
399726005331	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
399726005332	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498
399726005333	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
399726005334	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
399726005335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726005336	Walker A motif; other site
399726005337	ATP binding site [chemical binding]; other site
399726005338	Walker B motif; other site
399726005339	arginine finger; other site
399726005340	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
399726005341	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
399726005342	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
399726005343	GTP/Mg2+ binding site [chemical binding]; other site
399726005344	G4 box; other site
399726005345	G5 box; other site
399726005346	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005347	G1 box; other site
399726005348	G1 box; other site
399726005349	GTP/Mg2+ binding site [chemical binding]; other site
399726005350	Switch I region; other site
399726005351	G2 box; other site
399726005352	G2 box; other site
399726005353	Switch I region; other site
399726005354	G3 box; other site
399726005355	G3 box; other site
399726005356	Switch II region; other site
399726005357	Switch II region; other site
399726005358	G4 box; other site
399726005359	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
399726005360	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
399726005361	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
399726005362	RimM N-terminal domain; Region: RimM; pfam01782
399726005363	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
399726005364	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
399726005365	K homology RNA-binding domain, type I.  KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098
399726005366	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
399726005367	signal recognition particle protein; Provisional; Region: PRK10867
399726005368	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
399726005369	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
399726005370	P loop; other site
399726005371	GTP binding site [chemical binding]; other site
399726005372	Signal peptide binding domain; Region: SRP_SPB; pfam02978
399726005373	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726005374	DNA binding residues [nucleotide binding]
399726005375	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
399726005376	SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758
399726005377	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
399726005378	P loop; other site
399726005379	GTP binding site [chemical binding]; other site
399726005380	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
399726005381	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
399726005382	Walker A/P-loop; other site
399726005383	ATP binding site [chemical binding]; other site
399726005384	Q-loop/lid; other site
399726005385	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797
399726005386	Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function.  Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278
399726005387	ABC transporter signature motif; other site
399726005388	Walker B; other site
399726005389	D-loop; other site
399726005390	H-loop/switch region; other site
399726005391	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
399726005392	Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005
399726005393	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726005394	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
399726005395	FeS/SAM binding site; other site
399726005396	ribonuclease III; Reviewed; Region: rnc; PRK00102
399726005397	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
399726005398	dimerization interface [polypeptide binding]; other site
399726005399	active site
399726005400	metal binding site [ion binding]; metal-binding site
399726005401	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
399726005402	dsRNA binding site [nucleotide binding]; other site
399726005403	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
399726005404	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
399726005405	dimer interface [polypeptide binding]; other site
399726005406	active site
399726005407	Phosphopantetheine attachment site; Region: PP-binding; cl09936
399726005408	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
399726005409	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
399726005410	NAD(P) binding site [chemical binding]; other site
399726005411	homotetramer interface [polypeptide binding]; other site
399726005412	homodimer interface [polypeptide binding]; other site
399726005413	active site
399726005414	Acyl transferase domain; Region: Acyl_transf_1; cl08282
399726005415	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
399726005416	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
399726005417	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
399726005418	FMN binding site [chemical binding]; other site
399726005419	substrate binding site [chemical binding]; other site
399726005420	putative catalytic residue [active]
399726005421	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
399726005422	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
399726005423	dimer interface [polypeptide binding]; other site
399726005424	active site
399726005425	CoA binding pocket [chemical binding]; other site
399726005426	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
399726005427	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
399726005428	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
399726005429	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
399726005430	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
399726005431	Acetokinase family; Region: Acetate_kinase; cl01029
399726005432	propionate/acetate kinase; Provisional; Region: PRK12379
399726005433	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390
399726005434	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
399726005435	hypothetical protein; Provisional; Region: PRK13670
399726005436	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
399726005437	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
399726005438	Nucleoside recognition; Region: Gate; cl00486
399726005439	Nucleoside recognition; Region: Gate; cl00486
399726005440	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
399726005441	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
399726005442	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
399726005443	active site
399726005444	(T/H)XGH motif; other site
399726005445	Methyltransferase domain; Region: Methyltransf_31; pfam13847
399726005446	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726005447	S-adenosylmethionine binding site [chemical binding]; other site
399726005448	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
399726005449	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
399726005450	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
399726005451	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
399726005452	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
399726005453	generic binding surface II; other site
399726005454	ssDNA binding site; other site
399726005455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726005456	ATP binding site [chemical binding]; other site
399726005457	putative Mg++ binding site [ion binding]; other site
399726005458	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
399726005459	nucleotide binding region [chemical binding]; other site
399726005460	ATP-binding site [chemical binding]; other site
399726005461	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
399726005462	DAK2 domain; Region: Dak2; cl03685
399726005463	Uncharacterized protein, DegV family COG1307; Region: DegV; cl00577
399726005464	Asp23 family; Region: Asp23; cl00574
399726005465	Ribosomal L28 family; Region: Ribosomal_L28; cl00367
399726005466	Thiamine pyrophosphokinase; Region: TPK; cd07995
399726005467	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
399726005468	active site
399726005469	dimerization interface [polypeptide binding]; other site
399726005470	thiamine binding site [chemical binding]; other site
399726005471	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
399726005472	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
399726005473	substrate binding site [chemical binding]; other site
399726005474	hexamer interface [polypeptide binding]; other site
399726005475	metal binding site [ion binding]; metal-binding site
399726005476	GTPase RsgA; Reviewed; Region: PRK00098
399726005477	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
399726005478	RNA binding site [nucleotide binding]; other site
399726005479	homodimer interface [polypeptide binding]; other site
399726005480	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
399726005481	GTPase/Zn-binding domain interface [polypeptide binding]; other site
399726005482	GTP/Mg2+ binding site [chemical binding]; other site
399726005483	G4 box; other site
399726005484	G5 box; other site
399726005485	G1 box; other site
399726005486	Switch I region; other site
399726005487	G2 box; other site
399726005488	G3 box; other site
399726005489	Switch II region; other site
399726005490	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
399726005491	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
399726005492	active site
399726005493	ATP binding site [chemical binding]; other site
399726005494	substrate binding site [chemical binding]; other site
399726005495	activation loop (A-loop); other site
399726005496	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
399726005497	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
399726005498	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
399726005499	Protein phosphatase 2C; Region: PP2C; pfam00481
399726005500	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
399726005501	active site
399726005502	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
399726005503	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726005504	FeS/SAM binding site; other site
399726005505	16S rRNA methyltransferase B; Provisional; Region: PRK14902
399726005506	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
399726005507	putative RNA binding site [nucleotide binding]; other site
399726005508	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
399726005509	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049
399726005510	Protein of unknown function DUF116; Region: DUF116; cl00800
399726005511	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
399726005512	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
399726005513	putative active site [active]
399726005514	substrate binding site [chemical binding]; other site
399726005515	putative cosubstrate binding site; other site
399726005516	catalytic site [active]
399726005517	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
399726005518	substrate binding site [chemical binding]; other site
399726005519	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726005520	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726005521	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
399726005522	active site
399726005523	catalytic residues [active]
399726005524	metal binding site [ion binding]; metal-binding site
399726005525	primosome assembly protein PriA; Validated; Region: PRK05580
399726005526	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726005527	ATP binding site [chemical binding]; other site
399726005528	putative Mg++ binding site [ion binding]; other site
399726005529	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
399726005530	ATP-binding site [chemical binding]; other site
399726005531	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
399726005532	Flavoprotein; Region: Flavoprotein; cl08021
399726005533	DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410
399726005534	RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651
399726005535	Guanylate kinase; Region: Guanylate_kin; pfam00625
399726005536	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
399726005537	catalytic site [active]
399726005538	G-X2-G-X-G-K; other site
399726005539	Domain of unknown function (DUF370); Region: DUF370; cl00898
399726005540	hypothetical protein; Provisional; Region: PRK11820
399726005541	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
399726005542	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
399726005543	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
399726005544	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
399726005545	Diaminopimelate epimerase; Region: DAP_epimerase; cl14668
399726005546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726005547	Major Facilitator Superfamily; Region: MFS_1; pfam07690
399726005548	putative substrate translocation pore; other site
399726005549	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
399726005550	Domain of unknown function (DUF814); Region: DUF814; pfam05670
399726005551	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
399726005552	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
399726005553	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
399726005554	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
399726005555	MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport.  Other members of this system include the MetP permease and  the MetQ substrate binding protein.  ABC...; Region: ABC_MetN_methionine_transporter; cd03258
399726005556	Walker A/P-loop; other site
399726005557	ATP binding site [chemical binding]; other site
399726005558	Q-loop/lid; other site
399726005559	ABC transporter signature motif; other site
399726005560	Walker B; other site
399726005561	D-loop; other site
399726005562	H-loop/switch region; other site
399726005563	NIL domain; Region: NIL; cl09633
399726005564	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726005565	dimer interface [polypeptide binding]; other site
399726005566	conserved gate region; other site
399726005567	ABC-ATPase subunit interface; other site
399726005568	NMT1-like family; Region: NMT1_2; cl15260
399726005569	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
399726005570	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
399726005571	Cation efflux family; Region: Cation_efflux; cl00316
399726005572	UV-endonuclease UvdE; Region: UvdE; cl10036
399726005573	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
399726005574	Fe-S cluster binding site [ion binding]; other site
399726005575	active site
399726005576	Fumarase C-terminus; Region: Fumerase_C; cl00795
399726005577	Fumarate hydratase (Fumerase); Region: Fumerase; cl00851
399726005578	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
399726005579	Ligand Binding Site [chemical binding]; other site
399726005580	TIGR00269 family protein; Region: TIGR00269
399726005581	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
399726005582	homodimer interface [polypeptide binding]; other site
399726005583	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
399726005584	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
399726005585	active site
399726005586	homodimer interface [polypeptide binding]; other site
399726005587	catalytic site [active]
399726005588	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706
399726005589	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
399726005590	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
399726005591	S-layer homology domain; Region: SLH; pfam00395
399726005592	S-layer homology domain; Region: SLH; pfam00395
399726005593	S-layer homology domain; Region: SLH; pfam00395
399726005594	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
399726005595	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
399726005596	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726005597	NAD(P) binding site [chemical binding]; other site
399726005598	active site
399726005599	D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205
399726005600	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726005601	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
399726005602	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
399726005603	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
399726005604	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
399726005605	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
399726005606	active site
399726005607	Substrate binding site; other site
399726005608	Mg++ binding site; other site
399726005609	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
399726005610	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
399726005611	sulfate 1 binding site; other site
399726005612	Domain of unknown function (DUF377); Region: DUF377; pfam04041
399726005613	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
399726005614	active site
399726005615	Domain of unknown function (DUF377); Region: DUF377; pfam04041
399726005616	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
399726005617	active site
399726005618	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
399726005619	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381
399726005620	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
399726005621	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
399726005622	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
399726005623	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
399726005624	Walker A/P-loop; other site
399726005625	ATP binding site [chemical binding]; other site
399726005626	Q-loop/lid; other site
399726005627	ABC transporter signature motif; other site
399726005628	Walker B; other site
399726005629	D-loop; other site
399726005630	H-loop/switch region; other site
399726005631	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
399726005632	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
399726005633	The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE).  The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257
399726005634	Walker A/P-loop; other site
399726005635	ATP binding site [chemical binding]; other site
399726005636	Q-loop/lid; other site
399726005637	ABC transporter signature motif; other site
399726005638	Walker B; other site
399726005639	D-loop; other site
399726005640	H-loop/switch region; other site
399726005641	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
399726005642	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
399726005643	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
399726005644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726005645	dimer interface [polypeptide binding]; other site
399726005646	conserved gate region; other site
399726005647	putative PBP binding loops; other site
399726005648	ABC-ATPase subunit interface; other site
399726005649	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
399726005650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726005651	dimer interface [polypeptide binding]; other site
399726005652	conserved gate region; other site
399726005653	putative PBP binding loops; other site
399726005654	ABC-ATPase subunit interface; other site
399726005655	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
399726005656	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
399726005657	substrate binding site [chemical binding]; other site
399726005658	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
399726005659	putative active site [active]
399726005660	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
399726005661	active site
399726005662	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726005663	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
399726005664	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
399726005665	RNA binding surface [nucleotide binding]; other site
399726005666	PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553
399726005667	active site
399726005668	uracil binding [chemical binding]; other site
399726005669	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
399726005670	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726005671	NAD(P) binding site [chemical binding]; other site
399726005672	active site
399726005673	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
399726005674	Ligand Binding Site [chemical binding]; other site
399726005675	PUA domain; Region: PUA; cl00607
399726005676	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
399726005677	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726005678	S-adenosylmethionine binding site [chemical binding]; other site
399726005679	Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437
399726005680	orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455
399726005681	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
399726005682	active site
399726005683	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
399726005684	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
399726005685	heterodimer interface [polypeptide binding]; other site
399726005686	active site
399726005687	FMN binding site [chemical binding]; other site
399726005688	homodimer interface [polypeptide binding]; other site
399726005689	substrate binding site [chemical binding]; other site
399726005690	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
399726005691	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
399726005692	FAD binding pocket [chemical binding]; other site
399726005693	FAD binding motif [chemical binding]; other site
399726005694	phosphate binding motif [ion binding]; other site
399726005695	beta-alpha-beta structure motif; other site
399726005696	NAD binding pocket [chemical binding]; other site
399726005697	Iron coordination center [ion binding]; other site
399726005698	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725
399726005699	active site
399726005700	dimer interface [polypeptide binding]; other site
399726005701	dihydroorotase; Validated; Region: pyrC; PRK09357
399726005702	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
399726005703	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
399726005704	active site
399726005705	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
399726005706	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
399726005707	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726005708	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
399726005709	AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061
399726005710	dimerization interface [polypeptide binding]; other site
399726005711	putative ATP binding site [chemical binding]; other site
399726005712	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
399726005713	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
399726005714	RNA binding surface [nucleotide binding]; other site
399726005715	PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869
399726005716	active site
399726005717	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
399726005718	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
399726005719	N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357
399726005720	Protein of unknown function DUF45; Region: DUF45; cl00636
399726005721	Uncharacterized conserved protein [Function unknown]; Region: COG1700
399726005722	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
399726005723	Protein of unknown function (DUF524); Region: DUF524; pfam04411
399726005724	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
399726005725	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
399726005726	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005727	Restriction endonuclease [Defense mechanisms]; Region: COG3587
399726005728	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726005729	ATP binding site [chemical binding]; other site
399726005730	putative Mg++ binding site [ion binding]; other site
399726005731	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726005732	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
399726005733	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
399726005734	catalytic site [active]
399726005735	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
399726005736	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005737	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
399726005738	nucleotide binding region [chemical binding]; other site
399726005739	ATP-binding site [chemical binding]; other site
399726005740	CRISPR-associated protein; Region: TIGR03986
399726005741	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
399726005742	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
399726005743	CRISPR-associated protein, TIGR03984 family; Region: TIGR03984
399726005744	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
399726005745	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
399726005746	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726
399726005747	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592
399726005748	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
399726005749	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
399726005750	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732
399726005751	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784
399726005752	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
399726005753	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
399726005754	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
399726005755	Predicted permeases [General function prediction only]; Region: COG0730; cl00498
399726005756	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
399726005757	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
399726005758	dimer interface [polypeptide binding]; other site
399726005759	FMN binding site [chemical binding]; other site
399726005760	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726005761	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761
399726005762	Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800
399726005763	Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791
399726005764	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
399726005765	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
399726005766	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
399726005767	dimer interface [polypeptide binding]; other site
399726005768	substrate binding site [chemical binding]; other site
399726005769	metal binding site [ion binding]; metal-binding site
399726005770	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
399726005771	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
399726005772	Walker A; other site
399726005773	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
399726005774	B12 binding site [chemical binding]; other site
399726005775	cobalt ligand [ion binding]; other site
399726005776	Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884
399726005777	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
399726005778	Transglutaminase-like superfamily; Region: Transglut_core; cl10469
399726005779	Uncharacterized protein family UPF0047; Region: UPF0047; cl00439
399726005780	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
399726005781	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
399726005782	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
399726005783	homodimer interface [polypeptide binding]; other site
399726005784	substrate-cofactor binding pocket; other site
399726005785	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726005786	catalytic residue [active]
399726005787	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
399726005788	catalytic triad [active]
399726005789	NeuB family; Region: NeuB; cl00496
399726005790	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
399726005791	tryptophan synthase subunit alpha; Provisional; Region: trpA; PRK13111
399726005792	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
399726005793	substrate binding site [chemical binding]; other site
399726005794	active site
399726005795	catalytic residues [active]
399726005796	heterodimer interface [polypeptide binding]; other site
399726005797	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
399726005798	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
399726005799	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726005800	catalytic residue [active]
399726005801	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405
399726005802	active site
399726005803	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
399726005804	active site
399726005805	ribulose/triose binding site [chemical binding]; other site
399726005806	phosphate binding site [ion binding]; other site
399726005807	substrate (anthranilate) binding pocket [chemical binding]; other site
399726005808	product (indole) binding pocket [chemical binding]; other site
399726005809	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
399726005810	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
399726005811	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
399726005812	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
399726005813	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
399726005814	glutamine binding [chemical binding]; other site
399726005815	catalytic triad [active]
399726005816	anthranilate synthase component I; Provisional; Region: PRK13570
399726005817	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
399726005818	chorismate binding enzyme; Region: Chorismate_bind; cl10555
399726005819	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
399726005820	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
399726005821	putative active site [active]
399726005822	putative metal binding site [ion binding]; other site
399726005823	Domain of unknown function DUF77; Region: DUF77; cl00307
399726005824	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
399726005825	Helix-turn-helix domains; Region: HTH; cl00088
399726005826	Integrase core domain; Region: rve; cl01316
399726005827	Integrase core domain; Region: rve_3; cl15866
399726005828	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
399726005829	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
399726005830	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726005831	Walker A motif; other site
399726005832	ATP binding site [chemical binding]; other site
399726005833	Walker B motif; other site
399726005834	arginine finger; other site
399726005835	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
399726005836	homodimer interface [polypeptide binding]; other site
399726005837	substrate-cofactor binding pocket; other site
399726005838	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726005839	catalytic residue [active]
399726005840	QueT transporter; Region: QueT; cl01932
399726005841	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
399726005842	Cobalt transport protein; Region: CbiQ; cl00463
399726005843	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
399726005844	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726005845	Walker A/P-loop; other site
399726005846	ATP binding site [chemical binding]; other site
399726005847	Q-loop/lid; other site
399726005848	ABC transporter signature motif; other site
399726005849	Walker B; other site
399726005850	D-loop; other site
399726005851	H-loop/switch region; other site
399726005852	Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota.  The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed.  This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225
399726005853	Walker A/P-loop; other site
399726005854	ATP binding site [chemical binding]; other site
399726005855	Q-loop/lid; other site
399726005856	ABC transporter signature motif; other site
399726005857	Walker B; other site
399726005858	D-loop; other site
399726005859	H-loop/switch region; other site
399726005860	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
399726005861	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
399726005862	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242
399726005863	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
399726005864	putative NAD(P) binding site [chemical binding]; other site
399726005865	catalytic Zn binding site [ion binding]; other site
399726005866	structural Zn binding site [ion binding]; other site
399726005867	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
399726005868	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
399726005869	DNA-binding site [nucleotide binding]; DNA binding site
399726005870	UTRA domain; Region: UTRA; cl01230
399726005871	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
399726005872	intersubunit interface [polypeptide binding]; other site
399726005873	active site
399726005874	Zn2+ binding site [ion binding]; other site
399726005875	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
399726005876	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
399726005877	active site
399726005878	putative substrate binding pocket [chemical binding]; other site
399726005879	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
399726005880	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
399726005881	HIGH motif; other site
399726005882	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
399726005883	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
399726005884	active site
399726005885	KMSKS motif; other site
399726005886	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
399726005887	tRNA binding surface [nucleotide binding]; other site
399726005888	anticodon binding site; other site
399726005889	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
399726005890	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
399726005891	DivIVA protein; Region: DivIVA; pfam05103
399726005892	DivIVA domain; Region: DivI1A_domain; TIGR03544
399726005893	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
399726005894	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
399726005895	RNA binding surface [nucleotide binding]; other site
399726005896	YGGT family; Region: YGGT; cl00508
399726005897	Protein of unknown function (DUF552); Region: DUF552; cl00775
399726005898	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
399726005899	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
399726005900	catalytic residue [active]
399726005901	HlyD family secretion protein; Region: HlyD_2; pfam12700
399726005902	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
399726005903	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
399726005904	homotrimer interaction site [polypeptide binding]; other site
399726005905	putative active site [active]
399726005906	GntP family permease; Region: GntP_permease; pfam02447
399726005907	Na+-H+ antiporter family; Region: Na_H_antiport_2; cl15264
399726005908	Glycerate kinase family; Region: Gly_kinase; cl00841
399726005909	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
399726005910	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
399726005911	Helix-turn-helix domains; Region: HTH; cl00088
399726005912	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
399726005913	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
399726005914	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726005915	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
399726005916	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
399726005917	benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464
399726005918	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
399726005919	Transposase, Mutator family; Region: Transposase_mut; pfam00872
399726005920	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726005921	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726005922	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726005923	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726005924	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
399726005925	DAK2 domain; Region: Dak2; cl03685
399726005926	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
399726005927	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
399726005928	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
399726005929	D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
399726005930	N- and C-terminal domain interface [polypeptide binding]; other site
399726005931	D-xylulose kinase; Region: XylB; TIGR01312
399726005932	active site
399726005933	catalytic site [active]
399726005934	metal binding site [ion binding]; metal-binding site
399726005935	xylulose binding site [chemical binding]; other site
399726005936	putative ATP binding site [chemical binding]; other site
399726005937	homodimer interface [polypeptide binding]; other site
399726005938	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
399726005939	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
399726005940	tetramerization interface [polypeptide binding]; other site
399726005941	NAD(P) binding site [chemical binding]; other site
399726005942	catalytic residues [active]
399726005943	Cupin domain; Region: Cupin_2; cl09118
399726005944	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
399726005945	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726005946	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
399726005947	inhibitor site; inhibition site
399726005948	active site
399726005949	dimer interface [polypeptide binding]; other site
399726005950	catalytic residue [active]
399726005951	hypothetical protein; Provisional; Region: PRK08185
399726005952	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
399726005953	intersubunit interface [polypeptide binding]; other site
399726005954	active site
399726005955	zinc binding site [ion binding]; other site
399726005956	Na+ binding site [ion binding]; other site
399726005957	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
399726005958	phosphoglycolate phosphatase; Provisional; Region: PRK13222
399726005959	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
399726005960	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
399726005961	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
399726005962	PYR/PP interface [polypeptide binding]; other site
399726005963	dimer interface [polypeptide binding]; other site
399726005964	TPP binding site [chemical binding]; other site
399726005965	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
399726005966	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
399726005967	TPP-binding site [chemical binding]; other site
399726005968	dimer interface [polypeptide binding]; other site
399726005969	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108
399726005970	catalytic residue [active]
399726005971	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
399726005972	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
399726005973	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726005974	Walker A motif; other site
399726005975	ATP binding site [chemical binding]; other site
399726005976	Walker B motif; other site
399726005977	arginine finger; other site
399726005978	Helix-turn-helix domains; Region: HTH; cl00088
399726005979	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005980	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726005981	AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586
399726005982	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
399726005983	CobD/Cbib protein; Region: CobD_Cbib; cl00561
399726005984	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
399726005985	ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea.  Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
399726005986	Walker A/P-loop; other site
399726005987	ATP binding site [chemical binding]; other site
399726005988	Q-loop/lid; other site
399726005989	ABC transporter signature motif; other site
399726005990	Walker B; other site
399726005991	D-loop; other site
399726005992	H-loop/switch region; other site
399726005993	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
399726005994	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
399726005995	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
399726005996	ABC-ATPase subunit  interface; other site
399726005997	dimer interface [polypeptide binding]; other site
399726005998	putative PBP binding regions; other site
399726005999	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
399726006000	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
399726006001	putative binding site residues; other site
399726006002	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
399726006003	putative alcohol dehydrogenase; Provisional; Region: PRK09860
399726006004	dimer interface [polypeptide binding]; other site
399726006005	active site
399726006006	metal binding site [ion binding]; metal-binding site
399726006007	Acetokinase family; Region: Acetate_kinase; cl01029
399726006008	propionate/acetate kinase; Provisional; Region: PRK12379
399726006009	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
399726006010	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726006011	G1 box; other site
399726006012	GTP/Mg2+ binding site [chemical binding]; other site
399726006013	G2 box; other site
399726006014	Switch I region; other site
399726006015	G3 box; other site
399726006016	Switch II region; other site
399726006017	G4 box; other site
399726006018	G5 box; other site
399726006019	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
399726006020	putative hexamer interface [polypeptide binding]; other site
399726006021	putative hexagonal pore; other site
399726006022	ethanolamine utilization protein, PduT homolog; Region: eut_PduT; TIGR02526
399726006023	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduT_repeat1; cd07053
399726006024	putative hexamer interface [polypeptide binding]; other site
399726006025	putative hexagonal pore; other site
399726006026	1,2-propanediol utilization protein T (PduT), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduT_repeat2; cd07054
399726006027	putative hexamer interface [polypeptide binding]; other site
399726006028	putative hexagonal pore; other site
399726006029	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
399726006030	amphipathic channel; other site
399726006031	Asn-Pro-Ala signature motifs; other site
399726006032	Transposase domain (DUF772); Region: DUF772; cl15789
399726006033	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
399726006034	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
399726006035	putative catalytic cysteine [active]
399726006036	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; cl00920
399726006037	Domain of unknown function (DUF336); Region: DUF336; cl01249
399726006038	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
399726006039	Hexamer/Pentamer interface [polypeptide binding]; other site
399726006040	central pore; other site
399726006041	Flavoprotein; Region: Flavoprotein; cl08021
399726006042	ethanolamine utilization protein; Region: eut_hyp; TIGR02536
399726006043	ethanolamine utilization protein EutJ; Provisional; Region: PRK15080
399726006044	FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121
399726006045	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
399726006046	Propanediol utilisation protein PduL; Region: PduL; pfam06130
399726006047	Propanediol utilisation protein PduL; Region: PduL; pfam06130
399726006048	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
399726006049	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
399726006050	Hexamer interface [polypeptide binding]; other site
399726006051	Hexagonal pore residue; other site
399726006052	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
399726006053	Cell division protein FtsA; Region: FtsA; cl11496
399726006054	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
399726006055	Dehydratase small subunit; Region: Dehydratase_SU; cl02055
399726006056	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
399726006057	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
399726006058	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
399726006059	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
399726006060	alpha-beta subunit interface [polypeptide binding]; other site
399726006061	alpha-gamma subunit interface [polypeptide binding]; other site
399726006062	active site
399726006063	substrate and K+ binding site; other site
399726006064	K+ binding site [ion binding]; other site
399726006065	cobalamin binding site [chemical binding]; other site
399726006066	propanediol utilization protein PduB; Provisional; Region: PRK15415
399726006067	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
399726006068	putative hexamer interface [polypeptide binding]; other site
399726006069	putative hexagonal pore; other site
399726006070	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
399726006071	putative hexamer interface [polypeptide binding]; other site
399726006072	putative hexagonal pore; other site
399726006073	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
399726006074	Hexamer interface [polypeptide binding]; other site
399726006075	Hexagonal pore residue; other site
399726006076	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
399726006077	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
399726006078	Helix-turn-helix domains; Region: HTH; cl00088
399726006079	Integrase core domain; Region: rve; cl01316
399726006080	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
399726006081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726006082	active site
399726006083	phosphorylation site [posttranslational modification]
399726006084	intermolecular recognition site; other site
399726006085	dimerization interface [polypeptide binding]; other site
399726006086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
399726006087	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
399726006088	Sensory domain found in PocR; Region: PocR; pfam10114
399726006089	Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936
399726006090	Histidine kinase; Region: His_kinase; pfam06580
399726006091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726006092	ATP binding site [chemical binding]; other site
399726006093	Mg2+ binding site [ion binding]; other site
399726006094	G-X-G motif; other site
399726006095	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
399726006096	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668
399726006097	Uncharacterized conserved protein [Function unknown]; Region: COG3535
399726006098	Protein of unknown function (DUF917); Region: DUF917; pfam06032
399726006099	Sodium:solute symporter family; Region: SSF; cl00456
399726006100	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
399726006101	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726006102	Walker A motif; other site
399726006103	ATP binding site [chemical binding]; other site
399726006104	Walker B motif; other site
399726006105	arginine finger; other site
399726006106	Helix-turn-helix domains; Region: HTH; cl00088
399726006107	Protein of unknown function (DUF917); Region: DUF917; pfam06032
399726006108	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726006109	Major Facilitator Superfamily; Region: MFS_1; pfam07690
399726006110	putative substrate translocation pore; other site
399726006111	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726006112	putative substrate translocation pore; other site
399726006113	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726006114	Walker A/P-loop; other site
399726006115	ATP binding site [chemical binding]; other site
399726006116	ABC transporter; Region: ABC_tran; pfam00005
399726006117	Q-loop/lid; other site
399726006118	ABC transporter signature motif; other site
399726006119	Walker B; other site
399726006120	Helix-turn-helix domains; Region: HTH; cl00088
399726006121	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
399726006122	SEC-C motif; Region: SEC-C; pfam02810
399726006123	Amino acid permease; Region: AA_permease_2; pfam13520
399726006124	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
399726006125	putative acyl-acceptor binding pocket; other site
399726006126	Response regulator receiver domain; Region: Response_reg; pfam00072
399726006127	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726006128	active site
399726006129	phosphorylation site [posttranslational modification]
399726006130	intermolecular recognition site; other site
399726006131	dimerization interface [polypeptide binding]; other site
399726006132	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772
399726006133	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
399726006134	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726006135	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
399726006136	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
399726006137	GTP-binding protein Der; Reviewed; Region: PRK00093
399726006138	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
399726006139	G1 box; other site
399726006140	GTP/Mg2+ binding site [chemical binding]; other site
399726006141	Switch I region; other site
399726006142	G2 box; other site
399726006143	Switch II region; other site
399726006144	G3 box; other site
399726006145	G4 box; other site
399726006146	G5 box; other site
399726006147	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
399726006148	G1 box; other site
399726006149	GTP/Mg2+ binding site [chemical binding]; other site
399726006150	Switch I region; other site
399726006151	G2 box; other site
399726006152	G3 box; other site
399726006153	Switch II region; other site
399726006154	G4 box; other site
399726006155	G5 box; other site
399726006156	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
399726006157	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
399726006158	Protein of unknown function (DUF512); Region: DUF512; pfam04459
399726006159	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
399726006160	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
399726006161	YIEGIA protein; Region: YIEGIA; pfam14045
399726006162	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
399726006163	stage II sporulation protein P; Region: spore_II_P; TIGR02867
399726006164	Protein of unknown function (DUF1614); Region: DUF1614; cl15407
399726006165	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
399726006166	PhoU domain; Region: PhoU; pfam01895
399726006167	PhoU domain; Region: PhoU; pfam01895
399726006168	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
399726006169	Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient.  The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes.  The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260
399726006170	Walker A/P-loop; other site
399726006171	ATP binding site [chemical binding]; other site
399726006172	Q-loop/lid; other site
399726006173	ABC transporter signature motif; other site
399726006174	Walker B; other site
399726006175	D-loop; other site
399726006176	H-loop/switch region; other site
399726006177	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726006178	dimer interface [polypeptide binding]; other site
399726006179	conserved gate region; other site
399726006180	putative PBP binding loops; other site
399726006181	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
399726006182	ABC-ATPase subunit interface; other site
399726006183	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
399726006184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726006185	dimer interface [polypeptide binding]; other site
399726006186	conserved gate region; other site
399726006187	putative PBP binding loops; other site
399726006188	ABC-ATPase subunit interface; other site
399726006189	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726006190	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
399726006191	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
399726006192	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
399726006193	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
399726006194	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
399726006195	dimer interface [polypeptide binding]; other site
399726006196	phosphorylation site [posttranslational modification]
399726006197	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726006198	ATP binding site [chemical binding]; other site
399726006199	Mg2+ binding site [ion binding]; other site
399726006200	G-X-G motif; other site
399726006201	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
399726006202	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726006203	active site
399726006204	phosphorylation site [posttranslational modification]
399726006205	intermolecular recognition site; other site
399726006206	dimerization interface [polypeptide binding]; other site
399726006207	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
399726006208	DNA binding site [nucleotide binding]
399726006209	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
399726006210	ATP cone domain; Region: ATP-cone; pfam03477
399726006211	Photosynthetic reaction center (RC) complex, subunit H;  RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959
399726006212	sporulation sigma factor SigG; Reviewed; Region: PRK08215
399726006213	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726006214	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
399726006215	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726006216	DNA binding residues [nucleotide binding]
399726006217	sporulation sigma factor SigE; Reviewed; Region: PRK08301
399726006218	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
399726006219	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
399726006220	DNA binding residues [nucleotide binding]
399726006221	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
399726006222	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
399726006223	cell division protein FtsZ; Validated; Region: PRK09330
399726006224	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
399726006225	nucleotide binding site [chemical binding]; other site
399726006226	SulA interaction site; other site
399726006227	cell division protein FtsA; Region: ftsA; TIGR01174
399726006228	Cell division protein FtsA; Region: FtsA; cl11496
399726006229	Cell division protein FtsA; Region: FtsA; cl11496
399726006230	Protein of unknown function (DUF1290); Region: DUF1290; cl01587
399726006231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
399726006232	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
399726006233	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
399726006234	Cell division protein FtsQ; Region: FtsQ; pfam03799
399726006235	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
399726006236	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
399726006237	hinge; other site
399726006238	active site
399726006239	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
399726006240	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
399726006241	active site
399726006242	homodimer interface [polypeptide binding]; other site
399726006243	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
399726006244	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
399726006245	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726006246	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726006247	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
399726006248	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
399726006249	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
399726006250	Mg++ binding site [ion binding]; other site
399726006251	putative catalytic motif [active]
399726006252	putative substrate binding site [chemical binding]; other site
399726006253	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
399726006254	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
399726006255	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726006256	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
399726006257	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
399726006258	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
399726006259	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726006260	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
399726006261	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
399726006262	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
399726006263	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726006264	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
399726006265	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
399726006266	Septum formation initiator; Region: DivIC; cl11433
399726006267	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
399726006268	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726006269	cell division protein MraZ; Reviewed; Region: PRK00326
399726006270	MraZ protein; Region: MraZ; pfam02381
399726006271	MraZ protein; Region: MraZ; pfam02381
399726006272	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
399726006273	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
399726006274	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
399726006275	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
399726006276	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
399726006277	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
399726006278	GTP-binding protein YchF; Reviewed; Region: PRK09601
399726006279	YchF GTPase; Region: YchF; cd01900
399726006280	G1 box; other site
399726006281	GTP/Mg2+ binding site [chemical binding]; other site
399726006282	Switch I region; other site
399726006283	G2 box; other site
399726006284	Switch II region; other site
399726006285	G3 box; other site
399726006286	G4 box; other site
399726006287	G5 box; other site
399726006288	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
399726006289	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
399726006290	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
399726006291	THUMP domain; Region: THUMP; cl12076
399726006292	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
399726006293	Ligand Binding Site [chemical binding]; other site
399726006294	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
399726006295	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
399726006296	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726006297	catalytic residue [active]
399726006298	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
399726006299	putative homotetramer interface [polypeptide binding]; other site
399726006300	putative homodimer interface [polypeptide binding]; other site
399726006301	putative allosteric switch controlling residues; other site
399726006302	putative metal binding site [ion binding]; other site
399726006303	putative homodimer-homodimer interface [polypeptide binding]; other site
399726006304	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
399726006305	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726006306	putative active site [active]
399726006307	putative NTP binding site [chemical binding]; other site
399726006308	putative nucleic acid binding site [nucleotide binding]; other site
399726006309	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
399726006310	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
399726006311	dinuclear metal binding motif [ion binding]; other site
399726006312	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
399726006313	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
399726006314	E3 interaction surface; other site
399726006315	lipoyl attachment site [posttranslational modification]; other site
399726006316	e3 binding domain; Region: E3_binding; pfam02817
399726006317	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008
399726006318	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
399726006319	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
399726006320	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
399726006321	alpha subunit interface [polypeptide binding]; other site
399726006322	TPP binding site [chemical binding]; other site
399726006323	heterodimer interface [polypeptide binding]; other site
399726006324	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
399726006325	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
399726006326	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
399726006327	tetramer interface [polypeptide binding]; other site
399726006328	TPP-binding site [chemical binding]; other site
399726006329	heterodimer interface [polypeptide binding]; other site
399726006330	phosphorylation loop region [posttranslational modification]
399726006331	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807
399726006332	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
399726006333	GAF domain; Region: GAF; cl15785
399726006334	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
399726006335	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726006336	Walker A motif; other site
399726006337	ATP binding site [chemical binding]; other site
399726006338	Walker B motif; other site
399726006339	arginine finger; other site
399726006340	Helix-turn-helix domains; Region: HTH; cl00088
399726006341	lipoyl synthase; Provisional; Region: PRK05481
399726006342	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726006343	FeS/SAM binding site; other site
399726006344	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
399726006345	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726006346	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
399726006347	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726006348	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
399726006349	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
399726006350	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
399726006351	oligomer interface [polypeptide binding]; other site
399726006352	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
399726006353	putative active site [active]
399726006354	metal binding site [ion binding]; metal-binding site
399726006355	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
399726006356	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726006357	active site
399726006358	phosphorylation site [posttranslational modification]
399726006359	intermolecular recognition site; other site
399726006360	dimerization interface [polypeptide binding]; other site
399726006361	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
399726006362	DNA binding residues [nucleotide binding]
399726006363	dimerization interface [polypeptide binding]; other site
399726006364	Sensor protein DegS; Region: DegS; pfam05384
399726006365	Histidine kinase; Region: HisKA_3; pfam07730
399726006366	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
399726006367	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
399726006368	Protein of unknown function (DUF523); Region: DUF523; cl00733
399726006369	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
399726006370	MutS2 homologs in bacteria and eukaryotes.  The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280
399726006371	Walker A/P-loop; other site
399726006372	ATP binding site [chemical binding]; other site
399726006373	Q-loop/lid; other site
399726006374	ABC transporter signature motif; other site
399726006375	Walker B; other site
399726006376	D-loop; other site
399726006377	H-loop/switch region; other site
399726006378	Smr domain; Region: Smr; cl02619
399726006379	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
399726006380	Peptidase family U32; Region: Peptidase_U32; cl03113
399726006381	Collagenase; Region: DUF3656; pfam12392
399726006382	Peptidase family U32; Region: Peptidase_U32; cl03113
399726006383	Cell division protein ZapA; Region: ZapA; cl01146
399726006384	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
399726006385	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
399726006386	putative tRNA-binding site [nucleotide binding]; other site
399726006387	B3/4 domain; Region: B3_4; cl11458
399726006388	tRNA synthetase B5 domain; Region: B5; cl08394
399726006389	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
399726006390	dimer interface [polypeptide binding]; other site
399726006391	motif 1; other site
399726006392	motif 3; other site
399726006393	motif 2; other site
399726006394	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386
399726006395	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
399726006396	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
399726006397	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
399726006398	dimer interface [polypeptide binding]; other site
399726006399	motif 1; other site
399726006400	active site
399726006401	motif 2; other site
399726006402	motif 3; other site
399726006403	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
399726006404	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
399726006405	SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362
399726006406	ribosomal protein L20; Region: rpl20; CHL00068
399726006407	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
399726006408	23S rRNA binding site [nucleotide binding]; other site
399726006409	L21 binding site [polypeptide binding]; other site
399726006410	L13 binding site [polypeptide binding]; other site
399726006411	Ribosomal protein L35; Region: Ribosomal_L35p; cl00392
399726006412	translation initiation factor IF-3; Region: infC; TIGR00168
399726006413	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
399726006414	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
399726006415	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
399726006416	Tetramer interface [polypeptide binding]; other site
399726006417	active site
399726006418	FMN-binding site [chemical binding]; other site
399726006419	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726006420	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
399726006421	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
399726006422	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469
399726006423	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
399726006424	active site
399726006425	dimer interface [polypeptide binding]; other site
399726006426	motif 1; other site
399726006427	motif 2; other site
399726006428	motif 3; other site
399726006429	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
399726006430	anticodon binding site; other site
399726006431	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399
399726006432	YtxC-like family; Region: YtxC; cl08500
399726006433	Response regulator receiver domain; Region: Response_reg; pfam00072
399726006434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726006435	active site
399726006436	phosphorylation site [posttranslational modification]
399726006437	intermolecular recognition site; other site
399726006438	dimerization interface [polypeptide binding]; other site
399726006439	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
399726006440	metal binding site [ion binding]; metal-binding site
399726006441	active site
399726006442	I-site; other site
399726006443	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
399726006444	catalytic residues [active]
399726006445	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
399726006446	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
399726006447	dimerization interface [polypeptide binding]; other site
399726006448	domain crossover interface; other site
399726006449	redox-dependent activation switch; other site
399726006450	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458
399726006451	DNA-binding site [nucleotide binding]; DNA binding site
399726006452	RNA-binding motif; other site
399726006453	NAD-dependent deacetylase; Provisional; Region: PRK00481
399726006454	SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413
399726006455	NAD+ binding site [chemical binding]; other site
399726006456	substrate binding site [chemical binding]; other site
399726006457	Zn binding site [ion binding]; other site
399726006458	NifU-like domain; Region: NifU; cl00484
399726006459	GAF domain; Region: GAF_2; pfam13185
399726006460	GAF domain; Region: GAF; cl15785
399726006461	Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478
399726006462	dipeptidase PepV; Reviewed; Region: PRK07318
399726006463	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
399726006464	active site
399726006465	metal binding site [ion binding]; metal-binding site
399726006466	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
399726006467	dimerization interface [polypeptide binding]; other site
399726006468	putative DNA binding site [nucleotide binding]; other site
399726006469	putative Zn2+ binding site [ion binding]; other site
399726006470	Predicted permeases [General function prediction only]; Region: COG0701
399726006471	Predicted permease; Region: DUF318; pfam03773
399726006472	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
399726006473	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
399726006474	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
399726006475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385; cl00611
399726006476	RNA methyltransferase; Region: Methyltrans_RNA; pfam04452
399726006477	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
399726006478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
399726006479	S-adenosylmethionine binding site [chemical binding]; other site
399726006480	chaperone protein DnaJ; Provisional; Region: PRK14277
399726006481	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
399726006482	HSP70 interaction site [polypeptide binding]; other site
399726006483	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
399726006484	substrate binding site [polypeptide binding]; other site
399726006485	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
399726006486	Zn binding sites [ion binding]; other site
399726006487	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
399726006488	dimer interface [polypeptide binding]; other site
399726006489	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
399726006490	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
399726006491	dimer interface [polypeptide binding]; other site
399726006492	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
399726006493	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
399726006494	Helix-turn-helix domains; Region: HTH; cl00088
399726006495	HrcA protein C terminal domain; Region: HrcA; pfam01628
399726006496	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
399726006497	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726006498	FeS/SAM binding site; other site
399726006499	HemN C-terminal domain; Region: HemN_C; pfam06969
399726006500	GTP-binding protein LepA; Provisional; Region: PRK05433
399726006501	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
399726006502	G1 box; other site
399726006503	putative GEF interaction site [polypeptide binding]; other site
399726006504	GTP/Mg2+ binding site [chemical binding]; other site
399726006505	Switch I region; other site
399726006506	G2 box; other site
399726006507	G3 box; other site
399726006508	Switch II region; other site
399726006509	G4 box; other site
399726006510	G5 box; other site
399726006511	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
399726006512	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
399726006513	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
399726006514	Sulfatase; Region: Sulfatase; cl10460
399726006515	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
399726006516	stage II sporulation protein P; Region: spore_II_P; TIGR02867
399726006517	Germination protease; Region: Peptidase_A25; cl04057
399726006518	Membrane protein of unknown function; Region: DUF360; cl00850
399726006519	Ribosomal protein S20; Region: Ribosomal_S20p; cl00384
399726006520	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
399726006521	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
399726006522	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
399726006523	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
399726006524	Competence protein; Region: Competence; cl00471
399726006525	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726006526	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726006527	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726006528	motif II; other site
399726006529	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
399726006530	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
399726006531	alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902
399726006532	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
399726006533	homodimer interface [polypeptide binding]; other site
399726006534	substrate-cofactor binding pocket; other site
399726006535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726006536	catalytic residue [active]
399726006537	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
399726006538	4Fe-4S binding domain; Region: Fer4; cl02805
399726006539	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
399726006540	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
399726006541	active site
399726006542	HIGH motif; other site
399726006543	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
399726006544	active site
399726006545	KMSKS motif; other site
399726006546	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
399726006547	tetramer interfaces [polypeptide binding]; other site
399726006548	binuclear metal-binding site [ion binding]; other site
399726006549	SLBB domain; Region: SLBB; pfam10531
399726006550	comEA protein; Region: comE; TIGR01259
399726006551	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
399726006552	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
399726006553	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726006554	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
399726006555	asparagine synthetase B; Provisional; Region: asnB; PRK09431
399726006556	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
399726006557	active site
399726006558	dimer interface [polypeptide binding]; other site
399726006559	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
399726006560	Ligand Binding Site [chemical binding]; other site
399726006561	Molecular Tunnel; other site
399726006562	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
399726006563	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025
399726006564	substrate binding site [chemical binding]; other site
399726006565	B12 cofactor binding site [chemical binding]; other site
399726006566	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
399726006567	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
399726006568	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726006569	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
399726006570	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
399726006571	YheO-like PAS domain; Region: PAS_6; pfam08348
399726006572	Helix-turn-helix domains; Region: HTH; cl00088
399726006573	Oligomerisation domain; Region: Oligomerisation; cl00519
399726006574	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
399726006575	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076
399726006576	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
399726006577	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
399726006578	active site
399726006579	(T/H)XGH motif; other site
399726006580	GTPase CgtA; Reviewed; Region: obgE; PRK12297
399726006581	GTP1/OBG; Region: GTP1_OBG; pfam01018
399726006582	Obg GTPase; Region: Obg; cd01898
399726006583	G1 box; other site
399726006584	GTP/Mg2+ binding site [chemical binding]; other site
399726006585	Switch I region; other site
399726006586	G2 box; other site
399726006587	G3 box; other site
399726006588	Switch II region; other site
399726006589	G4 box; other site
399726006590	G5 box; other site
399726006591	Domain of unknown function (DUF1967); Region: DUF1967; cl07779
399726006592	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
399726006593	Protein of unknown function (DUF464); Region: DUF464; cl01080
399726006594	Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382
399726006595	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
399726006596	QueT transporter; Region: QueT; cl01932
399726006597	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
399726006598	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
399726006599	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
399726006600	homodimer interface [polypeptide binding]; other site
399726006601	oligonucleotide binding site [chemical binding]; other site
399726006602	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
399726006603	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090
399726006604	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
399726006605	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
399726006606	B12 binding site [chemical binding]; other site
399726006607	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
399726006608	FeS/SAM binding site; other site
399726006609	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
399726006610	active site
399726006611	putative substrate binding region [chemical binding]; other site
399726006612	Peptidase family M23; Region: Peptidase_M23; pfam01551
399726006613	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
399726006614	active site
399726006615	dimer interfaces [polypeptide binding]; other site
399726006616	catalytic residues [active]
399726006617	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
399726006618	Septum formation topological specificity factor MinE; Region: MinE; cl00538
399726006619	septum site-determining protein MinD; Region: minD_bact; TIGR01968
399726006620	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
399726006621	Switch I; other site
399726006622	Switch II; other site
399726006623	septum formation inhibitor; Reviewed; Region: minC; PRK00513
399726006624	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
399726006625	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
399726006626	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
399726006627	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726006628	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009
399726006629	rod shape-determining protein MreD; Region: MreD; cl01087
399726006630	Protein of unknown function (DUF904); Region: DUF904; cl11531
399726006631	rod shape-determining protein MreC; Region: MreC; pfam04085
399726006632	rod shape-determining protein MreB; Provisional; Region: PRK13927
399726006633	Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528
399726006634	ATP binding site [chemical binding]; other site
399726006635	gelsolin binding site; other site
399726006636	profilin binding site; other site
399726006637	hypothetical protein; Reviewed; Region: PRK00024
399726006638	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
399726006639	MPN+ (JAMM) motif; other site
399726006640	Zinc-binding site [ion binding]; other site
399726006641	Maf-like protein; Region: Maf; pfam02545
399726006642	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
399726006643	active site
399726006644	dimer interface [polypeptide binding]; other site
399726006645	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
399726006646	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
399726006647	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
399726006648	catalytic loop [active]
399726006649	iron binding site [ion binding]; other site
399726006650	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210
399726006651	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
399726006652	4Fe-4S binding domain; Region: Fer4; cl02805
399726006653	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
399726006654	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503
399726006655	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
399726006656	dimer interface [polypeptide binding]; other site
399726006657	[2Fe-2S] cluster binding site [ion binding]; other site
399726006658	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
399726006659	Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512
399726006660	SLBB domain; Region: SLBB; pfam10531
399726006661	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211
399726006662	4Fe-4S binding domain; Region: Fer4; cl02805
399726006663	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
399726006664	4Fe-4S binding domain; Region: Fer4; cl02805
399726006665	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
399726006666	dimer interface [polypeptide binding]; other site
399726006667	[2Fe-2S] cluster binding site [ion binding]; other site
399726006668	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726006669	ATP binding site [chemical binding]; other site
399726006670	Mg2+ binding site [ion binding]; other site
399726006671	G-X-G motif; other site
399726006672	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
399726006673	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
399726006674	putative dimer interface [polypeptide binding]; other site
399726006675	[2Fe-2S] cluster binding site [ion binding]; other site
399726006676	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
399726006677	DRTGG domain; Region: DRTGG; cl12147
399726006678	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
399726006679	4Fe-4S binding domain; Region: Fer4; cl02805
399726006680	4Fe-4S binding domain; Region: Fer4; cl02805
399726006681	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
399726006682	CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456
399726006683	Putative Fe-S cluster; Region: FeS; pfam04060
399726006684	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
399726006685	DRTGG domain; Region: DRTGG; cl12147
399726006686	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
399726006687	N-acetyl-D-glucosamine binding site [chemical binding]; other site
399726006688	catalytic residue [active]
399726006689	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
399726006690	GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394
399726006691	G1 box; other site
399726006692	putative GEF interaction site [polypeptide binding]; other site
399726006693	GTP/Mg2+ binding site [chemical binding]; other site
399726006694	Switch I region; other site
399726006695	G2 box; other site
399726006696	G3 box; other site
399726006697	Switch II region; other site
399726006698	G4 box; other site
399726006699	G5 box; other site
399726006700	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
399726006701	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
399726006702	Bacterial SH3 domain; Region: SH3_3; cl02551
399726006703	Bacterial SH3 domain; Region: SH3_3; cl02551
399726006704	Bacterial SH3 domain; Region: SH3_3; cl02551
399726006705	NlpC/P60 family; Region: NLPC_P60; cl11438
399726006706	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
399726006707	peptide binding site [polypeptide binding]; other site
399726006708	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
399726006709	dimer interface [polypeptide binding]; other site
399726006710	nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662
399726006711	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571
399726006712	active site
399726006713	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL).  LTs catalyze...; Region: LT_GEWL; cd00254
399726006714	N-acetyl-D-glucosamine binding site [chemical binding]; other site
399726006715	catalytic residue [active]
399726006716	dephospho-CoA kinase; Region: TIGR00152
399726006717	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
399726006718	CoA-binding site [chemical binding]; other site
399726006719	ATP-binding [chemical binding]; other site
399726006720	DNA polymerase I; Provisional; Region: PRK05755
399726006721	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
399726006722	active site
399726006723	metal binding site 1 [ion binding]; metal-binding site
399726006724	putative 5' ssDNA interaction site; other site
399726006725	metal binding site 3; metal-binding site
399726006726	metal binding site 2 [ion binding]; metal-binding site
399726006727	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
399726006728	putative DNA binding site [nucleotide binding]; other site
399726006729	putative metal binding site [ion binding]; other site
399726006730	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
399726006731	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
399726006732	active site
399726006733	DNA binding site [nucleotide binding]
399726006734	catalytic site [active]
399726006735	PspC domain; Region: PspC; cl00864
399726006736	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
399726006737	active site
399726006738	Glyco_18 domain; Region: Glyco_18; smart00636
399726006739	Protein of unknown function (DUF436); Region: DUF436; cl01860
399726006740	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
399726006741	Protein of unknown function DUF86; Region: DUF86; cl01031
399726006742	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
399726006743	active site
399726006744	NTP binding site [chemical binding]; other site
399726006745	metal binding triad [ion binding]; metal-binding site
399726006746	antibiotic binding site [chemical binding]; other site
399726006747	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
399726006748	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726006749	Walker A/P-loop; other site
399726006750	ATP binding site [chemical binding]; other site
399726006751	NlpC/P60 family; Region: NLPC_P60; cl11438
399726006752	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
399726006753	active sites [active]
399726006754	tetramer interface [polypeptide binding]; other site
399726006755	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
399726006756	Peptidase family M23; Region: Peptidase_M23; pfam01551
399726006757	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
399726006758	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
399726006759	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
399726006760	DNA-binding site [nucleotide binding]; DNA binding site
399726006761	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
399726006762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726006763	homodimer interface [polypeptide binding]; other site
399726006764	catalytic residue [active]
399726006765	isoaspartyl dipeptidase; Provisional; Region: PRK10657
399726006766	Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308
399726006767	dimer interface [polypeptide binding]; other site
399726006768	active site
399726006769	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
399726006770	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726006771	active site
399726006772	phosphorylation site [posttranslational modification]
399726006773	intermolecular recognition site; other site
399726006774	dimerization interface [polypeptide binding]; other site
399726006775	ANTAR domain; Region: ANTAR; cl04297
399726006776	glutamine synthetase, type I; Region: GlnA; TIGR00653
399726006777	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
399726006778	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
399726006779	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726006780	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
399726006781	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726006782	Walker A/P-loop; other site
399726006783	ATP binding site [chemical binding]; other site
399726006784	Q-loop/lid; other site
399726006785	ABC transporter signature motif; other site
399726006786	Walker B; other site
399726006787	D-loop; other site
399726006788	H-loop/switch region; other site
399726006789	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
399726006790	ABC transporter transmembrane region; Region: ABC_membrane; cl00549
399726006791	Glucan exporter ATP-binding protein.  In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor.  This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254
399726006792	Walker A/P-loop; other site
399726006793	ATP binding site [chemical binding]; other site
399726006794	Q-loop/lid; other site
399726006795	ABC transporter signature motif; other site
399726006796	Walker B; other site
399726006797	D-loop; other site
399726006798	H-loop/switch region; other site
399726006799	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
399726006800	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726006801	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856
399726006802	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
399726006803	dihydrodipicolinate synthase; Region: dapA; TIGR00674
399726006804	dimer interface [polypeptide binding]; other site
399726006805	active site
399726006806	catalytic residue [active]
399726006807	dihydrodipicolinate reductase; Provisional; Region: PRK00048
399726006808	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726006809	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
399726006810	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
399726006811	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
399726006812	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
399726006813	putative trimer interface [polypeptide binding]; other site
399726006814	putative CoA binding site [chemical binding]; other site
399726006815	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
399726006816	homodimer interface [polypeptide binding]; other site
399726006817	Walker A motif; other site
399726006818	ATP binding site [chemical binding]; other site
399726006819	hydroxycobalamin binding site [chemical binding]; other site
399726006820	Walker B motif; other site
399726006821	single-stranded DNA-binding protein; Provisional; Region: PRK05813
399726006822	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
399726006823	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
399726006824	dimer interface [polypeptide binding]; other site
399726006825	ssDNA binding site [nucleotide binding]; other site
399726006826	tetramer (dimer of dimers) interface [polypeptide binding]; other site
399726006827	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726006828	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
399726006829	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726006830	putative peptidoglycan binding site; other site
399726006831	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
399726006832	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
399726006833	Helix-turn-helix domains; Region: HTH; cl00088
399726006834	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726006835	Walker A motif; other site
399726006836	ATP binding site [chemical binding]; other site
399726006837	Walker B motif; other site
399726006838	arginine finger; other site
399726006839	DNA polymerase III subunits gamma and tau; Validated; Region: PRK08451
399726006840	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
399726006841	Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487
399726006842	active site
399726006843	catalytic triad [active]
399726006844	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
399726006845	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
399726006846	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
399726006847	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
399726006848	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
399726006849	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
399726006850	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726006851	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
399726006852	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726006853	dimer interface [polypeptide binding]; other site
399726006854	conserved gate region; other site
399726006855	putative PBP binding loops; other site
399726006856	ABC-ATPase subunit interface; other site
399726006857	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726006858	dimer interface [polypeptide binding]; other site
399726006859	conserved gate region; other site
399726006860	putative PBP binding loops; other site
399726006861	ABC-ATPase subunit interface; other site
399726006862	Transcriptional regulators [Transcription]; Region: PurR; COG1609
399726006863	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726006864	DNA binding site [nucleotide binding]
399726006865	domain linker motif; other site
399726006866	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
399726006867	dimerization interface [polypeptide binding]; other site
399726006868	ligand binding site [chemical binding]; other site
399726006869	beta-phosphoglucomutase; Region: bPGM; TIGR01990
399726006870	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
399726006871	motif II; other site
399726006872	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
399726006873	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726006874	dimer interface [polypeptide binding]; other site
399726006875	conserved gate region; other site
399726006876	putative PBP binding loops; other site
399726006877	ABC-ATPase subunit interface; other site
399726006878	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726006879	dimer interface [polypeptide binding]; other site
399726006880	conserved gate region; other site
399726006881	putative PBP binding loops; other site
399726006882	ABC-ATPase subunit interface; other site
399726006883	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
399726006884	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
399726006885	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
399726006886	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
399726006887	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
399726006888	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
399726006889	Transcriptional regulators [Transcription]; Region: PurR; COG1609
399726006890	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
399726006891	DNA binding site [nucleotide binding]
399726006892	domain linker motif; other site
399726006893	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
399726006894	dimerization interface [polypeptide binding]; other site
399726006895	ligand binding site [chemical binding]; other site
399726006896	iron-sulfur cluster binding protein, putative; Region: TIGR00276
399726006897	4Fe-4S binding domain; Region: Fer4; cl02805
399726006898	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
399726006899	Domain of unknown function (DUF4364); Region: DUF4364; pfam14277
399726006900	Uncharacterized conserved protein [Function unknown]; Region: COG3391
399726006901	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
399726006902	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
399726006903	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726006904	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
399726006905	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
399726006906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
399726006907	Coenzyme A binding pocket [chemical binding]; other site
399726006908	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
399726006909	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
399726006910	active site
399726006911	HIGH motif; other site
399726006912	nucleotide binding site [chemical binding]; other site
399726006913	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
399726006914	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
399726006915	active site
399726006916	KMSKS motif; other site
399726006917	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
399726006918	tRNA binding surface [nucleotide binding]; other site
399726006919	anticodon binding site; other site
399726006920	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
399726006921	Bifunctional nuclease; Region: DNase-RNase; cl00553
399726006922	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942
399726006923	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
399726006924	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
399726006925	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
399726006926	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
399726006927	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
399726006928	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
399726006929	active site
399726006930	phosphorylation site [posttranslational modification]
399726006931	intermolecular recognition site; other site
399726006932	dimerization interface [polypeptide binding]; other site
399726006933	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
399726006934	DNA binding site [nucleotide binding]
399726006935	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
399726006936	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726006937	dimerization interface [polypeptide binding]; other site
399726006938	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
399726006939	dimer interface [polypeptide binding]; other site
399726006940	phosphorylation site [posttranslational modification]
399726006941	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
399726006942	ATP binding site [chemical binding]; other site
399726006943	G-X-G motif; other site
399726006944	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
399726006945	AIR carboxylase; Region: AIRC; cl00310
399726006946	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
399726006947	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
399726006948	Ligand Binding Site [chemical binding]; other site
399726006949	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
399726006950	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
399726006951	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
399726006952	putative active site [active]
399726006953	putative NTP binding site [chemical binding]; other site
399726006954	putative nucleic acid binding site [nucleotide binding]; other site
399726006955	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
399726006956	Protein of unknown function (DUF458); Region: DUF458; cl00861
399726006957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726006958	Major Facilitator Superfamily; Region: MFS_1; pfam07690
399726006959	putative substrate translocation pore; other site
399726006960	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
399726006961	putative substrate translocation pore; other site
399726006962	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
399726006963	active site
399726006964	multimer interface [polypeptide binding]; other site
399726006965	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930
399726006966	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
399726006967	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
399726006968	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
399726006969	Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391
399726006970	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
399726006971	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
399726006972	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
399726006973	Uncharacterized membrane protein [Function unknown]; Region: COG3949
399726006974	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
399726006975	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
399726006976	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
399726006977	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726006978	Chain length determinant protein; Region: Wzz; cl15801
399726006979	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
399726006980	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
399726006981	active site
399726006982	tetramer interface; other site
399726006983	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
399726006984	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
399726006985	active site
399726006986	substrate binding site [chemical binding]; other site
399726006987	metal binding site [ion binding]; metal-binding site
399726006988	Transcription antiterminator [Transcription]; Region: NusG; COG0250
399726006989	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000
399726006990	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
399726006991	Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118
399726006992	predicted active site [active]
399726006993	catalytic triad [active]
399726006994	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
399726006995	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
399726006996	active site
399726006997	multimer interface [polypeptide binding]; other site
399726006998	Protein of unknown function DUF86; Region: DUF86; cl01031
399726006999	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
399726007000	active site
399726007001	NTP binding site [chemical binding]; other site
399726007002	metal binding triad [ion binding]; metal-binding site
399726007003	antibiotic binding site [chemical binding]; other site
399726007004	Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796
399726007005	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
399726007006	TIGR02680 family protein; Region: TIGR02680
399726007007	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726007008	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
399726007009	Protein of unknown function (DUF2398); Region: DUF2398; cl09875
399726007010	TIGR02677 family protein; Region: TIGR02677
399726007011	Protein of unknown function (DUF2397); Region: DUF2397; pfam09660
399726007012	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
399726007013	active site
399726007014	NTP binding site [chemical binding]; other site
399726007015	metal binding triad [ion binding]; metal-binding site
399726007016	antibiotic binding site [chemical binding]; other site
399726007017	manganese transport protein MntH; Reviewed; Region: PRK00701; cl15845
399726007018	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
399726007019	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178
399726007020	Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452
399726007021	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
399726007022	Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024
399726007023	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
399726007024	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
399726007025	active site
399726007026	catalytic tetrad [active]
399726007027	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
399726007028	active site
399726007029	metal binding site [ion binding]; metal-binding site
399726007030	homotetramer interface [polypeptide binding]; other site
399726007031	LemA family; Region: LemA; cl00742
399726007032	Peptidase family M48; Region: Peptidase_M48; cl12018
399726007033	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422
399726007034	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
399726007035	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726007036	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726007037	Walker A/P-loop; other site
399726007038	ATP binding site [chemical binding]; other site
399726007039	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
399726007040	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
399726007041	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
399726007042	ATP binding site [chemical binding]; other site
399726007043	putative Mg++ binding site [ion binding]; other site
399726007044	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
399726007045	nucleotide binding region [chemical binding]; other site
399726007046	ATP-binding site [chemical binding]; other site
399726007047	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
399726007048	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
399726007049	putative active site [active]
399726007050	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
399726007051	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
399726007052	SdpI/YhfL protein family; Region: SdpI; pfam13630
399726007053	Chain length determinant protein; Region: Wzz; cl15801
399726007054	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
399726007055	Chain length determinant protein; Region: Wzz; cl15801
399726007056	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
399726007057	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
399726007058	Substrate binding site; other site
399726007059	Cupin domain; Region: Cupin_2; cl09118
399726007060	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
399726007061	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726007062	Bacterial sugar transferase; Region: Bac_transf; cl00939
399726007063	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
399726007064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726007065	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
399726007066	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726007067	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
399726007068	This family is most closely related to the GT1 family of glycosyltransferases.  wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804
399726007069	putative ADP-binding pocket [chemical binding]; other site
399726007070	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
399726007071	putative trimer interface [polypeptide binding]; other site
399726007072	putative CoA binding site [chemical binding]; other site
399726007073	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
399726007074	putative homodimer interface [polypeptide binding]; other site
399726007075	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
399726007076	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
399726007077	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_7; cd05844
399726007078	putative ADP-binding pocket [chemical binding]; other site
399726007079	O-Antigen ligase; Region: Wzy_C; cl04850
399726007080	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
399726007081	Probable transposase; Region: OrfB_IS605; pfam01385
399726007082	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
399726007083	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
399726007084	Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762
399726007085	DNA binding residues [nucleotide binding]
399726007086	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
399726007087	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
399726007088	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
399726007089	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
399726007090	Mg2+ transporter (mgtE); Region: mgtE; TIGR00400
399726007091	MgtE intracellular N domain; Region: MgtE_N; cl15244
399726007092	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
399726007093	Divalent cation transporter; Region: MgtE; cl00786
399726007094	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
399726007095	NMT1-like family; Region: NMT1_2; cl15260
399726007096	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
399726007097	NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively.  ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293
399726007098	Walker A/P-loop; other site
399726007099	ATP binding site [chemical binding]; other site
399726007100	Q-loop/lid; other site
399726007101	ABC transporter signature motif; other site
399726007102	Walker B; other site
399726007103	D-loop; other site
399726007104	H-loop/switch region; other site
399726007105	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
399726007106	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
399726007107	dimer interface [polypeptide binding]; other site
399726007108	conserved gate region; other site
399726007109	putative PBP binding loops; other site
399726007110	ABC-ATPase subunit interface; other site
399726007111	NAD synthetase; Provisional; Region: PRK13981
399726007112	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
399726007113	multimer interface [polypeptide binding]; other site
399726007114	active site
399726007115	catalytic triad [active]
399726007116	protein interface 1 [polypeptide binding]; other site
399726007117	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
399726007118	homodimer interface [polypeptide binding]; other site
399726007119	NAD binding pocket [chemical binding]; other site
399726007120	ATP binding pocket [chemical binding]; other site
399726007121	Mg binding site [ion binding]; other site
399726007122	active-site loop [active]
399726007123	EamA-like transporter family; Region: EamA; cl01037
399726007124	EamA-like transporter family; Region: EamA; cl01037
399726007125	Predicted GTPase [General function prediction only]; Region: COG0218
399726007126	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
399726007127	G1 box; other site
399726007128	GTP/Mg2+ binding site [chemical binding]; other site
399726007129	Switch I region; other site
399726007130	G2 box; other site
399726007131	G3 box; other site
399726007132	Switch II region; other site
399726007133	G4 box; other site
399726007134	G5 box; other site
399726007135	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
399726007136	Found in ATP-dependent protease La (LON); Region: LON; smart00464
399726007137	Found in ATP-dependent protease La (LON); Region: LON; smart00464
399726007138	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726007139	Walker A motif; other site
399726007140	ATP binding site [chemical binding]; other site
399726007141	Walker B motif; other site
399726007142	arginine finger; other site
399726007143	Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214
399726007144	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
399726007145	ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964
399726007146	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726007147	Walker A motif; other site
399726007148	ATP binding site [chemical binding]; other site
399726007149	Walker B motif; other site
399726007150	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083
399726007151	Clp protease; Region: CLP_protease; pfam00574
399726007152	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
399726007153	oligomer interface [polypeptide binding]; other site
399726007154	active site residues [active]
399726007155	trigger factor; Provisional; Region: tig; PRK01490
399726007156	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587
399726007157	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
399726007158	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
399726007159	Helix-turn-helix domains; Region: HTH; cl00088
399726007160	Integrase core domain; Region: rve; cl01316
399726007161	CTP synthetase; Validated; Region: pyrG; PRK05380
399726007162	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
399726007163	Catalytic site [active]
399726007164	active site
399726007165	UTP binding site [chemical binding]; other site
399726007166	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
399726007167	active site
399726007168	putative oxyanion hole; other site
399726007169	catalytic triad [active]
399726007170	histidinol-phosphatase; Provisional; Region: PRK07328
399726007171	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
399726007172	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726007173	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
399726007174	putative L-serine binding site [chemical binding]; other site
399726007175	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
399726007176	homodimer interface [polypeptide binding]; other site
399726007177	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726007178	catalytic residue [active]
399726007179	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
399726007180	putative active site [active]
399726007181	catalytic triad [active]
399726007182	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
399726007183	putative integrin binding motif; other site
399726007184	PA/protease domain interface [polypeptide binding]; other site
399726007185	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
399726007186	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
399726007187	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
399726007188	Bacterial SH3 domain; Region: SH3_3; cl02551
399726007189	Bacterial SH3 domain; Region: SH3_3; cl02551
399726007190	Bacterial SH3 domain; Region: SH3_3; cl02551
399726007191	homoserine kinase; Provisional; Region: PRK01212
399726007192	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
399726007193	threonine synthase; Reviewed; Region: PRK06721
399726007194	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
399726007195	homodimer interface [polypeptide binding]; other site
399726007196	pyridoxal 5'-phosphate binding site [chemical binding]; other site
399726007197	catalytic residue [active]
399726007198	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726007199	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
399726007200	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
399726007201	hypothetical protein; Provisional; Region: PRK04435
399726007202	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
399726007203	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726007204	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
399726007205	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
399726007206	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
399726007207	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
399726007208	active site pocket [active]
399726007209	oxyanion hole [active]
399726007210	catalytic triad [active]
399726007211	active site nucleophile [active]
399726007212	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726007213	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726007214	Transposase; Region: DEDD_Tnp_IS110; pfam01548
399726007215	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
399726007216	CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641
399726007217	P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099
399726007218	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
399726007219	CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592
399726007220	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
399726007221	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
399726007222	CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730
399726007223	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
399726007224	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
399726007225	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
399726007226	trimerization site [polypeptide binding]; other site
399726007227	active site
399726007228	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
399726007229	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
399726007230	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726007231	catalytic residue [active]
399726007232	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
399726007233	FeS assembly protein SufB; Region: sufB; TIGR01980
399726007234	Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223
399726007235	FeS assembly ATPase SufC; Region: sufC; TIGR01978
399726007236	ABC-type transport system involved in Fe-S cluster assembly, ATPase component.  Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems.  The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217
399726007237	Walker A/P-loop; other site
399726007238	ATP binding site [chemical binding]; other site
399726007239	Q-loop/lid; other site
399726007240	ABC transporter signature motif; other site
399726007241	Walker B; other site
399726007242	D-loop; other site
399726007243	H-loop/switch region; other site
399726007244	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
399726007245	oligomerisation interface [polypeptide binding]; other site
399726007246	roof hairpin; other site
399726007247	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
399726007248	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
399726007249	catalytic residues [active]
399726007250	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
399726007251	catalytic residues [active]
399726007252	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
399726007253	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
399726007254	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
399726007255	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
399726007256	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
399726007257	active site
399726007258	HIGH motif; other site
399726007259	dimer interface [polypeptide binding]; other site
399726007260	KMSKS motif; other site
399726007261	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
399726007262	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
399726007263	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
399726007264	Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679
399726007265	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
399726007266	YyzF-like protein; Region: YyzF; cl15733
399726007267	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
399726007268	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
399726007269	protein binding site [polypeptide binding]; other site
399726007270	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
399726007271	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
399726007272	hinge; other site
399726007273	active site
399726007274	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
399726007275	Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118
399726007276	putative peptidoglycan binding site; other site
399726007277	G5 domain; Region: G5; pfam07501
399726007278	Peptidase family M23; Region: Peptidase_M23; pfam01551
399726007279	RnfC Barrel sandwich hybrid domain; Region: RnfC_N; pfam13375
399726007280	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
399726007281	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
399726007282	DNA replication protein DnaC; Validated; Region: PRK06835
399726007283	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
399726007284	Walker A motif; other site
399726007285	ATP binding site [chemical binding]; other site
399726007286	Walker B motif; other site
399726007287	arginine finger; other site
399726007288	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
399726007289	Zn binding site [ion binding]; other site
399726007290	Protein of unknown function (DUF1015); Region: DUF1015; cl01715
399726007291	Probable transposase; Region: OrfB_IS605; pfam01385
399726007292	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
399726007293	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
399726007294	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
399726007295	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
399726007296	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031
399726007297	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
399726007298	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
399726007299	GDP-binding site [chemical binding]; other site
399726007300	ACT binding site; other site
399726007301	IMP binding site; other site
399726007302	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
399726007303	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726007304	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
399726007305	dimerization interface [polypeptide binding]; other site
399726007306	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
399726007307	dimer interface [polypeptide binding]; other site
399726007308	putative CheW interface [polypeptide binding]; other site
399726007309	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
399726007310	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
399726007311	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
399726007312	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
399726007313	oligoendopeptidase F; Region: pepF; TIGR00181
399726007314	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609
399726007315	active site
399726007316	Zn binding site [ion binding]; other site
399726007317	Chromate transporter; Region: Chromate_transp; pfam02417
399726007318	Chromate transporter; Region: Chromate_transp; pfam02417
399726007319	ATP synthase subunit D; Region: ATP-synt_D; cl00613
399726007320	V-type ATP synthase subunit B; Provisional; Region: PRK04196
399726007321	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
399726007322	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
399726007323	Walker A motif homologous position; other site
399726007324	Walker B motif; other site
399726007325	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
399726007326	V-type ATP synthase subunit A; Provisional; Region: PRK04192
399726007327	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275
399726007328	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
399726007329	Walker A motif/ATP binding site; other site
399726007330	Walker B motif; other site
399726007331	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
399726007332	ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632
399726007333	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
399726007334	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
399726007335	ATP synthase (E/31 kDa) subunit; Region: vATP-synt_E; pfam01991
399726007336	V-type ATP synthase subunit K; Validated; Region: PRK06558
399726007337	ATP synthase subunit C; Region: ATP-synt_C; cl00466
399726007338	V-type ATP synthase subunit I; Validated; Region: PRK05771
399726007339	phosphodiesterase; Provisional; Region: PRK12704
399726007340	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
399726007341	uracil-xanthine permease; Region: ncs2; TIGR00801
399726007342	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
399726007343	This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE).  They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255
399726007344	Walker A/P-loop; other site
399726007345	ATP binding site [chemical binding]; other site
399726007346	Q-loop/lid; other site
399726007347	ABC transporter signature motif; other site
399726007348	Walker B; other site
399726007349	D-loop; other site
399726007350	H-loop/switch region; other site
399726007351	FtsX-like permease family; Region: FtsX; cl15850
399726007352	Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387
399726007353	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
399726007354	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
399726007355	ligand binding site [chemical binding]; other site
399726007356	flexible hinge region; other site
399726007357	Helix-turn-helix domains; Region: HTH; cl00088
399726007358	replicative DNA helicase; Region: DnaB; TIGR00665
399726007359	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
399726007360	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
399726007361	Walker A motif; other site
399726007362	ATP binding site [chemical binding]; other site
399726007363	Walker B motif; other site
399726007364	DNA binding loops [nucleotide binding]
399726007365	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
399726007366	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
399726007367	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
399726007368	Predicted membrane protein (DUF2232); Region: DUF2232; cl01728
399726007369	MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345
399726007370	Ribosomal protein S18; Region: Ribosomal_S18; cl00373
399726007371	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
399726007372	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
399726007373	dimer interface [polypeptide binding]; other site
399726007374	ssDNA binding site [nucleotide binding]; other site
399726007375	tetramer (dimer of dimers) interface [polypeptide binding]; other site
399726007376	Ribosomal protein S6; Region: Ribosomal_S6; cl00414
399726007377	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
399726007378	Mechanosensitive ion channel; Region: MS_channel; pfam00924
399726007379	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
399726007380	cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068
399726007381	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726007382	ATP-grasp domain; Region: ATP-grasp_4; cl03087
399726007383	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
399726007384	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
399726007385	Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145
399726007386	proposed catalytic triad [active]
399726007387	active site nucleophile [active]
399726007388	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
399726007389	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255
399726007390	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
399726007391	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
399726007392	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
399726007393	catalytic residue [active]
399726007394	ParB-like partition proteins; Region: parB_part; TIGR00180
399726007395	ParB-like nuclease domain; Region: ParBc; cl02129
399726007396	KorB domain; Region: KorB; pfam08535
399726007397	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
399726007398	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
399726007399	P-loop; other site
399726007400	Magnesium ion binding site [ion binding]; other site
399726007401	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
399726007402	Magnesium ion binding site [ion binding]; other site
399726007403	ParB-like nuclease domain; Region: ParBc; cl02129
399726007404	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
399726007405	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
399726007406	nudix motif; other site
399726007407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl15754
399726007408	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
399726007409	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
399726007410	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
399726007411	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
399726007412	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
399726007413	trmE is a tRNA modification GTPase; Region: trmE; cd04164
399726007414	G1 box; other site
399726007415	GTP/Mg2+ binding site [chemical binding]; other site
399726007416	Switch I region; other site
399726007417	G2 box; other site
399726007418	Switch II region; other site
399726007419	G3 box; other site
399726007420	G4 box; other site
399726007421	G5 box; other site
399726007422	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
399726007423	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
399726007424	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
399726007425	G-X-X-G motif; other site
399726007426	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
399726007427	RxxxH motif; other site
399726007428	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
399726007429	Haemolytic domain; Region: Haemolytic; cl00506
399726007430	Ribonuclease P; Region: Ribonuclease_P; cl00457
399726007431	Ribosomal protein L34; Region: Ribosomal_L34; cl00370