-- dump date 20111121_015244 -- class Genbank::misc_feature -- table misc_feature_note -- id note 509193000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 509193000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193000003 Walker A motif; other site 509193000004 ATP binding site [chemical binding]; other site 509193000005 Walker B motif; other site 509193000006 arginine finger; other site 509193000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 509193000008 DnaA box-binding interface [nucleotide binding]; other site 509193000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 509193000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 509193000011 putative DNA binding surface [nucleotide binding]; other site 509193000012 dimer interface [polypeptide binding]; other site 509193000013 beta-clamp/clamp loader binding surface; other site 509193000014 beta-clamp/translesion DNA polymerase binding surface; other site 509193000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 509193000016 recombination protein F; Reviewed; Region: recF; PRK00064 509193000017 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000018 Walker A/P-loop; other site 509193000019 ATP binding site [chemical binding]; other site 509193000020 Q-loop/lid; other site 509193000021 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000022 ABC transporter signature motif; other site 509193000023 Walker B; other site 509193000024 D-loop; other site 509193000025 H-loop/switch region; other site 509193000026 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 509193000027 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 509193000028 trimer interface [polypeptide binding]; other site 509193000029 active site 509193000030 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 509193000031 catalytic site [active] 509193000032 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 509193000033 catalytic triad [active] 509193000034 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193000035 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 509193000036 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 509193000037 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 509193000038 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 509193000039 anchoring element; other site 509193000040 dimer interface [polypeptide binding]; other site 509193000041 ATP binding site [chemical binding]; other site 509193000042 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 509193000043 active site 509193000044 putative metal-binding site [ion binding]; other site 509193000045 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 509193000046 DNA gyrase subunit A; Validated; Region: PRK05560 509193000047 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 509193000048 CAP-like domain; other site 509193000049 Active site [active] 509193000050 primary dimer interface [polypeptide binding]; other site 509193000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509193000052 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509193000053 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509193000054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509193000055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509193000056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 509193000057 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 509193000058 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 509193000059 active site 509193000060 FMN binding site [chemical binding]; other site 509193000061 substrate binding site [chemical binding]; other site 509193000062 homotetramer interface [polypeptide binding]; other site 509193000063 catalytic residue [active] 509193000064 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 509193000065 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 509193000066 putative valine binding site [chemical binding]; other site 509193000067 dimer interface [polypeptide binding]; other site 509193000068 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 509193000069 ketol-acid reductoisomerase; Provisional; Region: PRK05479 509193000070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193000071 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 509193000072 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 509193000073 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 509193000074 active site 509193000075 catalytic residues [active] 509193000076 metal binding site [ion binding]; metal-binding site 509193000077 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 509193000078 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 509193000079 substrate binding site [chemical binding]; other site 509193000080 ligand binding site [chemical binding]; other site 509193000081 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 509193000082 substrate binding site [chemical binding]; other site 509193000083 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 509193000084 isocitrate dehydrogenase; Validated; Region: PRK06451 509193000085 Dehydratase family; Region: ILVD_EDD; cl00340 509193000086 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 509193000087 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 509193000088 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 509193000089 PYR/PP interface [polypeptide binding]; other site 509193000090 dimer interface [polypeptide binding]; other site 509193000091 TPP binding site [chemical binding]; other site 509193000092 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 509193000093 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 509193000094 TPP-binding site [chemical binding]; other site 509193000095 dimer interface [polypeptide binding]; other site 509193000096 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 509193000097 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 509193000098 catalytic motif [active] 509193000099 Zn binding site [ion binding]; other site 509193000100 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 509193000101 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 509193000102 Lumazine binding domain; Region: Lum_binding; pfam00677 509193000103 Lumazine binding domain; Region: Lum_binding; pfam00677 509193000104 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 509193000105 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 509193000106 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 509193000107 dimerization interface [polypeptide binding]; other site 509193000108 active site 509193000109 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 509193000110 homopentamer interface [polypeptide binding]; other site 509193000111 active site 509193000112 Domain of unknown function DUF20; Region: UPF0118; cl00465 509193000113 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 509193000114 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 509193000115 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 509193000116 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 509193000117 Catalytic site [active] 509193000118 seryl-tRNA synthetase; Provisional; Region: PRK05431 509193000119 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 509193000120 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 509193000121 dimer interface [polypeptide binding]; other site 509193000122 active site 509193000123 motif 1; other site 509193000124 motif 2; other site 509193000125 motif 3; other site 509193000126 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 509193000127 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 509193000128 Int/Topo IB signature motif; other site 509193000129 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 509193000130 putative active site [active] 509193000131 catalytic site [active] 509193000132 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509193000133 non-specific DNA binding site [nucleotide binding]; other site 509193000134 salt bridge; other site 509193000135 sequence-specific DNA binding site [nucleotide binding]; other site 509193000136 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509193000137 non-specific DNA binding site [nucleotide binding]; other site 509193000138 salt bridge; other site 509193000139 sequence-specific DNA binding site [nucleotide binding]; other site 509193000140 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509193000141 trehalose repressor; Provisional; Region: treR; PRK09492 509193000142 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193000143 Zn2+ binding site [ion binding]; other site 509193000144 Mg2+ binding site [ion binding]; other site 509193000145 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 509193000146 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 509193000147 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 509193000148 plasmid segregation protein ParM; Provisional; Region: PRK13917 509193000149 StbA protein; Region: StbA; pfam06406 509193000150 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193000151 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193000152 putative active site [active] 509193000153 putative NTP binding site [chemical binding]; other site 509193000154 putative nucleic acid binding site [nucleotide binding]; other site 509193000155 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193000156 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 509193000157 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 509193000158 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000159 Walker A motif; other site 509193000160 ATP binding site [chemical binding]; other site 509193000161 Walker B motif; other site 509193000162 Integrase core domain; Region: rve; cl01316 509193000163 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 509193000164 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000165 AAA-like domain; Region: AAA_10; pfam12846 509193000166 Domain of unknown function DUF87; Region: DUF87; pfam01935 509193000167 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509193000168 Peptidase family M23; Region: Peptidase_M23; pfam01551 509193000169 SAF domain; Region: SAF; cl00555 509193000170 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 509193000171 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 509193000172 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 509193000173 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 509193000174 Walker A motif; other site 509193000175 hexamer interface [polypeptide binding]; other site 509193000176 ATP binding site [chemical binding]; other site 509193000177 Walker B motif; other site 509193000178 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 509193000179 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 509193000180 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509193000181 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 509193000182 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 509193000183 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 509193000184 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193000185 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193000186 Zn2+ binding site [ion binding]; other site 509193000187 Mg2+ binding site [ion binding]; other site 509193000188 plasmid segregation protein ParM; Provisional; Region: PRK13917 509193000189 StbA protein; Region: StbA; pfam06406 509193000190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193000191 FeS/SAM binding site; other site 509193000192 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 509193000193 AAA-like domain; Region: AAA_10; pfam12846 509193000194 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 509193000195 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 509193000196 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509193000197 CHC2 zinc finger; Region: zf-CHC2; cl02597 509193000198 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509193000199 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 509193000200 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 509193000201 Phage integrase family; Region: Phage_integrase; pfam00589 509193000202 Int/Topo IB signature motif; other site 509193000203 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 509193000204 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193000205 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 509193000206 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193000207 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193000208 putative active site [active] 509193000209 putative NTP binding site [chemical binding]; other site 509193000210 putative nucleic acid binding site [nucleotide binding]; other site 509193000211 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193000212 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 509193000213 Zn binding site [ion binding]; other site 509193000214 DNA replication protein DnaC; Validated; Region: PRK06835 509193000215 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193000216 Walker A motif; other site 509193000217 ATP binding site [chemical binding]; other site 509193000218 Walker B motif; other site 509193000219 arginine finger; other site 509193000220 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 509193000221 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 509193000222 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193000223 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509193000224 putative peptidoglycan binding site; other site 509193000225 G5 domain; Region: G5; pfam07501 509193000226 Peptidase family M23; Region: Peptidase_M23; pfam01551 509193000227 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 509193000228 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 509193000229 hinge; other site 509193000230 active site 509193000231 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 509193000232 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 509193000233 protein binding site [polypeptide binding]; other site 509193000234 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 509193000235 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 509193000236 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 509193000237 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 509193000238 active site 509193000239 HIGH motif; other site 509193000240 dimer interface [polypeptide binding]; other site 509193000241 KMSKS motif; other site 509193000242 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509193000243 RNA binding surface [nucleotide binding]; other site 509193000244 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 509193000245 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 509193000246 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 509193000247 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193000248 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193000249 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 509193000250 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509193000251 catalytic residues [active] 509193000252 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide...; Region: NrdH; cd02976 509193000253 catalytic residues [active] 509193000254 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 509193000255 oligomerisation interface [polypeptide binding]; other site 509193000256 roof hairpin; other site 509193000257 FeS assembly ATPase SufC; Region: sufC; TIGR01978 509193000258 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 509193000259 Walker A/P-loop; other site 509193000260 ATP binding site [chemical binding]; other site 509193000261 Q-loop/lid; other site 509193000262 ABC transporter signature motif; other site 509193000263 Walker B; other site 509193000264 D-loop; other site 509193000265 H-loop/switch region; other site 509193000266 FeS assembly protein SufB; Region: sufB; TIGR01980 509193000267 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 509193000268 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 509193000269 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 509193000270 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 509193000271 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509193000272 catalytic residue [active] 509193000273 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 509193000274 trimerization site [polypeptide binding]; other site 509193000275 active site 509193000276 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 509193000277 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 509193000278 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 509193000279 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 509193000280 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 509193000281 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 509193000282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 509193000283 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 509193000284 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193000285 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193000286 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193000287 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193000288 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193000289 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193000290 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 509193000291 active site pocket [active] 509193000292 oxyanion hole [active] 509193000293 catalytic triad [active] 509193000294 active site nucleophile [active] 509193000295 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 509193000296 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 509193000297 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 509193000298 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 509193000299 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 509193000300 active site 509193000301 FMN binding site [chemical binding]; other site 509193000302 substrate binding site [chemical binding]; other site 509193000303 putative catalytic residue [active] 509193000304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193000305 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193000306 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193000307 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 509193000308 putative active site [active] 509193000309 putative NTP binding site [chemical binding]; other site 509193000310 putative nucleic acid binding site [nucleotide binding]; other site 509193000311 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193000312 hypothetical protein; Provisional; Region: PRK04435 509193000313 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 509193000314 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193000315 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 509193000316 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 509193000317 threonine synthase; Reviewed; Region: PRK06721 509193000318 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants...; Region: Thr-synth_1; cd01563 509193000319 homodimer interface [polypeptide binding]; other site 509193000320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193000321 catalytic residue [active] 509193000322 homoserine kinase; Provisional; Region: PRK01212 509193000323 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 509193000324 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 509193000325 putative active site [active] 509193000326 catalytic triad [active] 509193000327 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 509193000328 putative integrin binding motif; other site 509193000329 PA/protease domain interface [polypeptide binding]; other site 509193000330 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 509193000331 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 509193000332 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 509193000333 Bacterial SH3 domain; Region: SH3_3; cl02551 509193000334 Bacterial SH3 domain; Region: SH3_3; cl02551 509193000335 Bacterial SH3 domain; Region: SH3_3; cl02551 509193000336 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT), serine-...; Region: AGAT_like; cd06451 509193000337 homodimer interface [polypeptide binding]; other site 509193000338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193000339 catalytic residue [active] 509193000340 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 509193000341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193000342 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 509193000343 putative L-serine binding site [chemical binding]; other site 509193000344 histidinol-phosphatase; Provisional; Region: PRK07328 509193000345 CTP synthetase; Validated; Region: pyrG; PRK05380 509193000346 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 509193000347 Catalytic site [active] 509193000348 Active site [active] 509193000349 UTP binding site [chemical binding]; other site 509193000350 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 509193000351 active site 509193000352 putative oxyanion hole; other site 509193000353 catalytic triad [active] 509193000354 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193000355 Integrase core domain; Region: rve; cl01316 509193000356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193000357 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 509193000358 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 509193000359 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 509193000360 putative substrate binding site [chemical binding]; other site 509193000361 putative ATP binding site [chemical binding]; other site 509193000362 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509193000363 active site 509193000364 phosphorylation site [posttranslational modification] 509193000365 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 509193000366 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 509193000367 P-loop; other site 509193000368 active site 509193000369 phosphorylation site [posttranslational modification] 509193000370 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 509193000371 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 509193000372 putative dimer interface [polypeptide binding]; other site 509193000373 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 509193000374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193000375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193000376 DNA binding site [nucleotide binding] 509193000377 domain linker motif; other site 509193000378 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 509193000379 putative dimerization interface [polypeptide binding]; other site 509193000380 putative ligand binding site [chemical binding]; other site 509193000381 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 509193000382 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509193000383 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193000384 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509193000385 pur operon repressor; Provisional; Region: PRK09213 509193000386 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 509193000387 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193000388 SpoVG; Region: SpoVG; cl00915 509193000389 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 509193000390 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 509193000391 Substrate binding site [chemical binding]; other site 509193000392 Mg++ binding site [ion binding]; other site 509193000393 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 509193000394 active site 509193000395 substrate binding site [chemical binding]; other site 509193000396 CoA binding site [chemical binding]; other site 509193000397 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 509193000398 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193000399 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193000400 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193000401 putative active site [active] 509193000402 putative NTP binding site [chemical binding]; other site 509193000403 putative nucleic acid binding site [nucleotide binding]; other site 509193000404 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193000405 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509193000406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193000407 active site 509193000408 phosphorylation site [posttranslational modification] 509193000409 intermolecular recognition site; other site 509193000410 dimerization interface [polypeptide binding]; other site 509193000411 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 509193000412 DNA binding site [nucleotide binding] 509193000413 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509193000414 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 509193000415 dimerization interface [polypeptide binding]; other site 509193000416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 509193000417 dimer interface [polypeptide binding]; other site 509193000418 phosphorylation site [posttranslational modification] 509193000419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193000420 ATP binding site [chemical binding]; other site 509193000421 Mg2+ binding site [ion binding]; other site 509193000422 G-X-G motif; other site 509193000423 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 509193000424 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 509193000425 protein binding site [polypeptide binding]; other site 509193000426 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 509193000427 putative active site [active] 509193000428 catalytic residue [active] 509193000429 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 509193000430 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 509193000431 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509193000432 ATP binding site [chemical binding]; other site 509193000433 putative Mg++ binding site [ion binding]; other site 509193000434 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509193000435 nucleotide binding region [chemical binding]; other site 509193000436 ATP-binding site [chemical binding]; other site 509193000437 TRCF domain; Region: TRCF; pfam03461 509193000438 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 509193000439 SurA N-terminal domain; Region: SurA_N; pfam09312 509193000440 PPIC-type PPIASE domain; Region: Rotamase; cl08278 509193000441 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 509193000442 stage V sporulation protein T; Region: spore_V_T; TIGR02851 509193000443 YabG peptidase U57; Region: Peptidase_U57; cl05250 509193000444 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193000445 Integrase core domain; Region: rve; cl01316 509193000446 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 509193000447 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 509193000448 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 509193000449 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 509193000450 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cl00107 509193000451 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 509193000452 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 509193000453 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 509193000454 Transcriptional regulators [Transcription]; Region: GntR; COG1802 509193000455 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509193000456 DNA-binding site [nucleotide binding]; DNA binding site 509193000457 FCD domain; Region: FCD; cl11656 509193000458 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 509193000459 active site 509193000460 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 509193000461 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 509193000462 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 509193000463 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 509193000464 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 509193000465 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193000466 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 509193000467 germination protein YpeB; Region: spore_YpeB; TIGR02889 509193000468 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 509193000469 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 509193000470 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 509193000471 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 509193000472 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193000473 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 509193000474 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 509193000475 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 509193000476 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 509193000477 active site 509193000478 HIGH motif; other site 509193000479 KMSK motif region; other site 509193000480 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 509193000481 tRNA binding surface [nucleotide binding]; other site 509193000482 anticodon binding site; other site 509193000483 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 509193000484 ATPase (PilT family) [General function prediction only]; Region: COG1855 509193000485 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000486 Walker A/P-loop; other site 509193000487 ATP binding site [chemical binding]; other site 509193000488 Q-loop/lid; other site 509193000489 ABC transporter signature motif; other site 509193000490 Walker B; other site 509193000491 D-loop; other site 509193000492 H-loop/switch region; other site 509193000493 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193000494 translocation protein TolB; Provisional; Region: tolB; PRK02889 509193000495 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000496 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 509193000497 Walker A/P-loop; other site 509193000498 ATP binding site [chemical binding]; other site 509193000499 Q-loop/lid; other site 509193000500 ABC transporter signature motif; other site 509193000501 Walker B; other site 509193000502 D-loop; other site 509193000503 H-loop/switch region; other site 509193000504 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 509193000505 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509193000506 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 509193000507 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509193000508 Transposase IS200 like; Region: Y1_Tnp; cl00848 509193000509 hypothetical protein; Provisional; Region: PRK04140 509193000510 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193000511 putative substrate translocation pore; other site 509193000512 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509193000513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193000514 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 509193000515 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193000516 Walker A/P-loop; other site 509193000517 ATP binding site [chemical binding]; other site 509193000518 Q-loop/lid; other site 509193000519 ABC transporter signature motif; other site 509193000520 Walker B; other site 509193000521 D-loop; other site 509193000522 H-loop/switch region; other site 509193000523 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193000524 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 509193000525 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193000526 Walker A/P-loop; other site 509193000527 ATP binding site [chemical binding]; other site 509193000528 Q-loop/lid; other site 509193000529 ABC transporter signature motif; other site 509193000530 Walker B; other site 509193000531 D-loop; other site 509193000532 H-loop/switch region; other site 509193000533 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193000534 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 509193000535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193000536 dimer interface [polypeptide binding]; other site 509193000537 conserved gate region; other site 509193000538 putative PBP binding loops; other site 509193000539 ABC-ATPase subunit interface; other site 509193000540 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 509193000541 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 509193000542 Protein of unknown function (DUF561); Region: DUF561; pfam04481 509193000543 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 509193000544 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 509193000545 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 509193000546 active site 509193000547 catalytic tetrad [active] 509193000548 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 509193000549 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 509193000550 NlpC/P60 family; Region: NLPC_P60; cl11438 509193000551 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 509193000552 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 509193000553 putative catalytic cysteine [active] 509193000554 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 509193000555 putative active site [active] 509193000556 metal binding site [ion binding]; metal-binding site 509193000557 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 509193000558 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 509193000559 DNA binding site [nucleotide binding] 509193000560 active site 509193000561 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193000562 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509193000563 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193000564 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000565 Walker A/P-loop; other site 509193000566 ATP binding site [chemical binding]; other site 509193000567 Q-loop/lid; other site 509193000568 ABC transporter signature motif; other site 509193000569 Walker B; other site 509193000570 D-loop; other site 509193000571 H-loop/switch region; other site 509193000572 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509193000573 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193000574 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 509193000575 Walker A/P-loop; other site 509193000576 ATP binding site [chemical binding]; other site 509193000577 Q-loop/lid; other site 509193000578 ABC transporter signature motif; other site 509193000579 Walker B; other site 509193000580 D-loop; other site 509193000581 H-loop/switch region; other site 509193000582 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; cl01588 509193000583 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 509193000584 active site 509193000585 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 509193000586 magnesium-transporting ATPase; Provisional; Region: PRK15122 509193000587 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509193000588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193000589 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 509193000590 hypothetical protein; Provisional; Region: PRK08609 509193000591 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 509193000592 active site 509193000593 primer binding site [nucleotide binding]; other site 509193000594 NTP binding site [chemical binding]; other site 509193000595 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 509193000596 putative oxidoreductase; Provisional; Region: PRK12831 509193000597 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 509193000598 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193000599 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 509193000600 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like1; cd06219 509193000601 FAD binding pocket [chemical binding]; other site 509193000602 FAD binding motif [chemical binding]; other site 509193000603 phosphate binding motif [ion binding]; other site 509193000604 beta-alpha-beta structure motif; other site 509193000605 NAD binding pocket [chemical binding]; other site 509193000606 Iron coordination center [ion binding]; other site 509193000607 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 509193000608 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 509193000609 tetramer interface [polypeptide binding]; other site 509193000610 catalytic Zn binding site [ion binding]; other site 509193000611 NADP binding site [chemical binding]; other site 509193000612 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193000613 Integrase core domain; Region: rve; cl01316 509193000614 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 509193000615 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 509193000616 putative active site [active] 509193000617 metal binding site [ion binding]; metal-binding site 509193000618 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 509193000619 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 509193000620 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878 509193000621 Putative Fe-S cluster; Region: FeS; pfam04060 509193000622 PAS domain S-box; Region: sensory_box; TIGR00229 509193000623 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509193000624 putative active site [active] 509193000625 heme pocket [chemical binding]; other site 509193000626 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 509193000627 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 509193000628 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 509193000629 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193000630 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 509193000631 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 509193000632 heterotetramer interface [polypeptide binding]; other site 509193000633 active site pocket [active] 509193000634 cleavage site 509193000635 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 509193000636 feedback inhibition sensing region; other site 509193000637 homohexameric interface [polypeptide binding]; other site 509193000638 nucleotide binding site [chemical binding]; other site 509193000639 N-acetyl-L-glutamate binding site [chemical binding]; other site 509193000640 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 509193000641 acetylornithine aminotransferase; Provisional; Region: PRK02627 509193000642 inhibitor-cofactor binding pocket; inhibition site 509193000643 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193000644 catalytic residue [active] 509193000645 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 509193000646 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 509193000647 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 509193000648 catalytic site [active] 509193000649 subunit interface [polypeptide binding]; other site 509193000650 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 509193000651 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509193000652 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193000653 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 509193000654 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 509193000655 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193000656 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 509193000657 substrate binding site [chemical binding]; other site 509193000658 argininosuccinate synthase; Provisional; Region: PLN00200 509193000659 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 509193000660 ANP binding site [chemical binding]; other site 509193000661 Substrate Binding Site II [chemical binding]; other site 509193000662 Substrate Binding Site I [chemical binding]; other site 509193000663 argininosuccinate lyase; Provisional; Region: PRK00855 509193000664 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 509193000665 active sites [active] 509193000666 tetramer interface [polypeptide binding]; other site 509193000667 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 509193000668 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 509193000669 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509193000670 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193000671 motif II; other site 509193000672 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 509193000673 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509193000674 catalytic core [active] 509193000675 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509193000676 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 509193000677 Ferritin-like domain; Region: Ferritin; pfam00210 509193000678 ferroxidase diiron center [ion binding]; other site 509193000679 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 509193000680 trimer interface [polypeptide binding]; other site 509193000681 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 509193000682 ApbE family; Region: ApbE; cl00643 509193000683 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 509193000684 Integrase core domain; Region: rve; cl01316 509193000685 FMN-binding domain; Region: FMN_bind; cl01081 509193000686 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 509193000687 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small...; Region: DSRD; cd00974 509193000688 non-heme iron binding site [ion binding]; other site 509193000689 dimer interface [polypeptide binding]; other site 509193000690 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion...; Region: SORL_Dfx_classI; cd03171 509193000691 non-heme iron binding site [ion binding]; other site 509193000692 dimer interface [polypeptide binding]; other site 509193000693 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 509193000694 Aspartase; Region: Aspartase; cd01357 509193000695 active sites [active] 509193000696 tetramer interface [polypeptide binding]; other site 509193000697 hydrogenase maturation GTPase HydF; Region: GTP_HydF; TIGR03918 509193000698 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 509193000699 G1 box; other site 509193000700 GTP/Mg2+ binding site [chemical binding]; other site 509193000701 Switch I region; other site 509193000702 G2 box; other site 509193000703 Switch II region; other site 509193000704 G3 box; other site 509193000705 G4 box; other site 509193000706 G5 box; other site 509193000707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193000708 H+ Antiporter protein; Region: 2A0121; TIGR00900 509193000709 putative substrate translocation pore; other site 509193000710 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 509193000711 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 509193000712 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 509193000713 binding surface 509193000714 TPR motif; other site 509193000715 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 509193000716 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 509193000717 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 509193000718 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 509193000719 IHF dimer interface [polypeptide binding]; other site 509193000720 IHF - DNA interface [nucleotide binding]; other site 509193000721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 509193000722 Stage II sporulation protein; Region: SpoIID; cl07201 509193000723 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 509193000724 YabP family; Region: YabP; cl06766 509193000725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 509193000726 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193000727 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 509193000728 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 509193000729 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 509193000730 DRTGG domain; Region: DRTGG; cl12147 509193000731 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl10010 509193000732 DHH family; Region: DHH; pfam01368 509193000733 DHHA2 domain; Region: DHHA2; pfam02833 509193000734 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 509193000735 Septum formation initiator; Region: DivIC; cl11433 509193000736 hypothetical protein; Provisional; Region: PRK05807 509193000737 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 509193000738 RNA binding site [nucleotide binding]; other site 509193000739 exopolyphosphatase; Region: exo_poly_only; TIGR03706 509193000740 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 509193000741 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 509193000742 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193000743 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 509193000744 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193000745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193000746 dimer interface [polypeptide binding]; other site 509193000747 conserved gate region; other site 509193000748 putative PBP binding loops; other site 509193000749 ABC-ATPase subunit interface; other site 509193000750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193000751 dimer interface [polypeptide binding]; other site 509193000752 conserved gate region; other site 509193000753 putative PBP binding loops; other site 509193000754 ABC-ATPase subunit interface; other site 509193000755 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 509193000756 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 509193000757 Transposase, Mutator family; Region: Transposase_mut; pfam00872 509193000758 MULE transposase domain; Region: MULE; pfam10551 509193000759 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 509193000760 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 509193000761 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509193000762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193000763 active site 509193000764 phosphorylation site [posttranslational modification] 509193000765 intermolecular recognition site; other site 509193000766 dimerization interface [polypeptide binding]; other site 509193000767 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 509193000768 DNA binding site [nucleotide binding] 509193000769 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 509193000770 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 509193000771 dimer interface [polypeptide binding]; other site 509193000772 phosphorylation site [posttranslational modification] 509193000773 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193000774 ATP binding site [chemical binding]; other site 509193000775 Mg2+ binding site [ion binding]; other site 509193000776 G-X-G motif; other site 509193000777 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 509193000778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509193000779 dimerization interface [polypeptide binding]; other site 509193000780 putative DNA binding site [nucleotide binding]; other site 509193000781 putative Zn2+ binding site [ion binding]; other site 509193000782 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 509193000783 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 509193000784 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509193000785 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193000786 cysteine synthases; Region: cysKM; TIGR01136 509193000787 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 509193000788 dimer interface [polypeptide binding]; other site 509193000789 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193000790 catalytic residue [active] 509193000791 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 509193000792 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509193000793 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509193000794 catalytic residue [active] 509193000795 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 509193000796 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 509193000797 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509193000798 metal-binding site [ion binding] 509193000799 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 509193000800 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 509193000801 metal-binding site [ion binding] 509193000802 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509193000803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193000804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 509193000805 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 509193000806 active site 509193000807 metal binding site [ion binding]; metal-binding site 509193000808 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 509193000809 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 509193000810 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 509193000811 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 509193000812 substrate-cofactor binding pocket; other site 509193000813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193000814 catalytic residue [active] 509193000815 Threonine dehydrogenase; Region: TDH; cd05281 509193000816 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 509193000817 structural Zn binding site [ion binding]; other site 509193000818 catalytic Zn binding site [ion binding]; other site 509193000819 tetramer interface [polypeptide binding]; other site 509193000820 NADP binding site [chemical binding]; other site 509193000821 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 509193000822 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 509193000823 dimer interface [polypeptide binding]; other site 509193000824 PYR/PP interface [polypeptide binding]; other site 509193000825 TPP binding site [chemical binding]; other site 509193000826 substrate binding site [chemical binding]; other site 509193000827 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 509193000828 Domain of unknown function; Region: EKR; pfam10371 509193000829 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 509193000830 TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This subfamily also includes proteins characterized as...; Region: TPP_PFOR_PNO; cd03377 509193000831 TPP-binding site [chemical binding]; other site 509193000832 dimer interface [polypeptide binding]; other site 509193000833 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 509193000834 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 509193000835 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509193000836 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 509193000837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193000838 Walker A/P-loop; other site 509193000839 ATP binding site [chemical binding]; other site 509193000840 Q-loop/lid; other site 509193000841 ABC transporter signature motif; other site 509193000842 Walker B; other site 509193000843 D-loop; other site 509193000844 H-loop/switch region; other site 509193000845 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 509193000846 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 509193000847 EamA-like transporter family; Region: EamA; cl01037 509193000848 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 509193000849 EamA-like transporter family; Region: EamA; cl01037 509193000850 stage II sporulation protein E; Region: spore_II_E; TIGR02865 509193000851 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 509193000852 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 509193000853 Ligand Binding Site [chemical binding]; other site 509193000854 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 509193000855 B3/4 domain; Region: B3_4; cl11458 509193000856 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193000857 FtsH Extracellular; Region: FtsH_ext; pfam06480 509193000858 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 509193000859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193000860 Walker A motif; other site 509193000861 ATP binding site [chemical binding]; other site 509193000862 Walker B motif; other site 509193000863 arginine finger; other site 509193000864 Peptidase family M41; Region: Peptidase_M41; pfam01434 509193000865 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509193000866 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 509193000867 sensory histidine kinase AtoS; Provisional; Region: PRK11360 509193000868 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 509193000869 dimer interface [polypeptide binding]; other site 509193000870 phosphorylation site [posttranslational modification] 509193000871 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193000872 ATP binding site [chemical binding]; other site 509193000873 Mg2+ binding site [ion binding]; other site 509193000874 G-X-G motif; other site 509193000875 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 509193000876 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 509193000877 Potassium binding sites [ion binding]; other site 509193000878 Cesium cation binding sites [ion binding]; other site 509193000879 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 509193000880 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 509193000881 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 509193000882 pyruvate carboxylase subunit B; Validated; Region: PRK09282 509193000883 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 509193000884 carboxyltransferase (CT) interaction site; other site 509193000885 biotinylation site [posttranslational modification]; other site 509193000886 Predicted membrane protein [Function unknown]; Region: COG4684 509193000887 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 509193000888 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 509193000889 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 509193000890 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 509193000891 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 509193000892 Predicted dehydrogenase [General function prediction only]; Region: COG5322 509193000893 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 509193000894 NADP binding site [chemical binding]; other site 509193000895 domain; Region: GreA_GreB_N; pfam03449 509193000896 C-term; Region: GreA_GreB; pfam01272 509193000897 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 509193000898 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 509193000899 dimer interface [polypeptide binding]; other site 509193000900 putative anticodon binding site; other site 509193000901 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 509193000902 motif 1; other site 509193000903 active site 509193000904 motif 2; other site 509193000905 motif 3; other site 509193000906 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 509193000907 homodecamer interface [polypeptide binding]; other site 509193000908 GTP cyclohydrolase I; Provisional; Region: PLN03044 509193000909 active site 509193000910 putative catalytic site residues [active] 509193000911 zinc binding site [ion binding]; other site 509193000912 GTP-CH-I/GFRP interaction surface; other site 509193000913 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 509193000914 dihydropteroate synthase; Region: DHPS; TIGR01496 509193000915 substrate binding pocket [chemical binding]; other site 509193000916 dimer interface [polypeptide binding]; other site 509193000917 inhibitor binding site; inhibition site 509193000918 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 509193000919 catalytic center binding site [active] 509193000920 ATP binding site [chemical binding]; other site 509193000921 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 509193000922 active site 509193000923 Sugar fermentation stimulation protein; Region: SfsA; cl00647 509193000924 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 509193000925 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509193000926 Protein of unknown function (DUF1614); Region: DUF1614; cl01694 509193000927 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 509193000928 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 509193000929 inhibitor-cofactor binding pocket; inhibition site 509193000930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193000931 catalytic residue [active] 509193000932 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 509193000933 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 509193000934 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 509193000935 active site 509193000936 dimer interface [polypeptide binding]; other site 509193000937 effector binding site; other site 509193000938 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 509193000939 TSCPD domain; Region: TSCPD; cl14834 509193000940 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 509193000941 GAF domain; Region: GAF; cl00853 509193000942 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509193000943 metal binding site [ion binding]; metal-binding site 509193000944 active site 509193000945 I-site; other site 509193000946 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 509193000947 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193000948 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193000949 PRD domain; Region: PRD; pfam00874 509193000950 PRD domain; Region: PRD; pfam00874 509193000951 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 509193000952 P-loop; other site 509193000953 active site 509193000954 phosphorylation site [posttranslational modification] 509193000955 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509193000956 active site 509193000957 phosphorylation site [posttranslational modification] 509193000958 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509193000959 active site 509193000960 phosphorylation site [posttranslational modification] 509193000961 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA...; Region: PTS_IIB_fructose; cd05569 509193000962 P-loop; other site 509193000963 active site 509193000964 phosphorylation site [posttranslational modification] 509193000965 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 509193000966 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 509193000967 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 509193000968 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 509193000969 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 509193000970 elongation factor G; Reviewed; Region: PRK12740 509193000971 G1 box; other site 509193000972 putative GEF interaction site [polypeptide binding]; other site 509193000973 GTP/Mg2+ binding site [chemical binding]; other site 509193000974 Switch I region; other site 509193000975 G2 box; other site 509193000976 G3 box; other site 509193000977 Switch II region; other site 509193000978 G4 box; other site 509193000979 G5 box; other site 509193000980 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 509193000981 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 509193000982 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 509193000983 Malic enzyme, N-terminal domain; Region: malic; pfam00390 509193000984 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 509193000985 putative NAD(P) binding site [chemical binding]; other site 509193000986 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 509193000987 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 509193000988 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 509193000989 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 509193000990 ADP binding site [chemical binding]; other site 509193000991 phosphagen binding site; other site 509193000992 substrate specificity loop; other site 509193000993 Clp protease ATP binding subunit; Region: clpC; CHL00095 509193000994 Clp amino terminal domain; Region: Clp_N; pfam02861 509193000995 Clp amino terminal domain; Region: Clp_N; pfam02861 509193000996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193000997 Walker A motif; other site 509193000998 ATP binding site [chemical binding]; other site 509193000999 Walker B motif; other site 509193001000 arginine finger; other site 509193001001 UvrB/uvrC motif; Region: UVR; pfam02151 509193001002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193001003 Walker A motif; other site 509193001004 ATP binding site [chemical binding]; other site 509193001005 Walker B motif; other site 509193001006 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 509193001007 DNA repair protein RadA; Provisional; Region: PRK11823 509193001008 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 509193001009 Walker A motif/ATP binding site; other site 509193001010 ATP binding site [chemical binding]; other site 509193001011 Walker B motif; other site 509193001012 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 509193001013 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 509193001014 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 509193001015 putative active site [active] 509193001016 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 509193001017 substrate binding site [chemical binding]; other site 509193001018 dimer interface [polypeptide binding]; other site 509193001019 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509193001020 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 509193001021 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 509193001022 homotrimer interaction site [polypeptide binding]; other site 509193001023 zinc binding site [ion binding]; other site 509193001024 CDP-binding sites; other site 509193001025 prolyl-tRNA synthetase; Provisional; Region: PRK09194 509193001026 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 509193001027 dimer interface [polypeptide binding]; other site 509193001028 motif 1; other site 509193001029 active site 509193001030 motif 2; other site 509193001031 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 509193001032 putative deacylase active site [active] 509193001033 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509193001034 active site 509193001035 motif 3; other site 509193001036 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 509193001037 anticodon binding site; other site 509193001038 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 509193001039 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 509193001040 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509193001041 HIGH motif; other site 509193001042 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509193001043 active site 509193001044 KMSKS motif; other site 509193001045 serine O-acetyltransferase; Region: cysE; TIGR01172 509193001046 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 509193001047 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of L-...; Region: LbH_SAT; cd03354 509193001048 trimer interface [polypeptide binding]; other site 509193001049 active site 509193001050 substrate binding site [chemical binding]; other site 509193001051 CoA binding site [chemical binding]; other site 509193001052 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 509193001053 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509193001054 active site 509193001055 HIGH motif; other site 509193001056 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 509193001057 KMSKS motif; other site 509193001058 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 509193001059 tRNA binding surface [nucleotide binding]; other site 509193001060 anticodon binding site; other site 509193001061 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 509193001062 active site 509193001063 metal binding site [ion binding]; metal-binding site 509193001064 dimerization interface [polypeptide binding]; other site 509193001065 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 509193001066 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 509193001067 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 509193001068 YacP-like NYN domain; Region: NYN_YacP; cl01491 509193001069 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 509193001070 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193001071 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 509193001072 elongation factor Tu; Reviewed; Region: PRK00049 509193001073 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 509193001074 G1 box; other site 509193001075 GEF interaction site [polypeptide binding]; other site 509193001076 GTP/Mg2+ binding site [chemical binding]; other site 509193001077 Switch I region; other site 509193001078 G2 box; other site 509193001079 G3 box; other site 509193001080 Switch II region; other site 509193001081 G4 box; other site 509193001082 G5 box; other site 509193001083 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509193001084 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 509193001085 Antibiotic Binding Site [chemical binding]; other site 509193001086 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 509193001087 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 509193001088 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 509193001089 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 509193001090 putative homodimer interface [polypeptide binding]; other site 509193001091 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 509193001092 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 509193001093 23S rRNA interface [nucleotide binding]; other site 509193001094 L7/L12 interface [polypeptide binding]; other site 509193001095 putative thiostrepton binding site; other site 509193001096 L25 interface [polypeptide binding]; other site 509193001097 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 509193001098 mRNA/rRNA interface [nucleotide binding]; other site 509193001099 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 509193001100 23S rRNA interface [nucleotide binding]; other site 509193001101 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 509193001102 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 509193001103 core dimer interface [polypeptide binding]; other site 509193001104 peripheral dimer interface [polypeptide binding]; other site 509193001105 L10 interface [polypeptide binding]; other site 509193001106 L11 interface [polypeptide binding]; other site 509193001107 putative EF-Tu interaction site [polypeptide binding]; other site 509193001108 putative EF-G interaction site [polypeptide binding]; other site 509193001109 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 509193001110 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 509193001111 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 509193001112 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 509193001113 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 509193001114 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 509193001115 RPB1 interaction site [polypeptide binding]; other site 509193001116 RPB10 interaction site [polypeptide binding]; other site 509193001117 RPB11 interaction site [polypeptide binding]; other site 509193001118 RPB3 interaction site [polypeptide binding]; other site 509193001119 RPB12 interaction site [polypeptide binding]; other site 509193001120 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 509193001121 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 509193001122 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 509193001123 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 509193001124 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 509193001125 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 509193001126 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 509193001127 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 509193001128 G-loop; other site 509193001129 DNA binding site [nucleotide binding] 509193001130 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 509193001131 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 509193001132 S17 interaction site [polypeptide binding]; other site 509193001133 S8 interaction site; other site 509193001134 16S rRNA interaction site [nucleotide binding]; other site 509193001135 streptomycin interaction site [chemical binding]; other site 509193001136 23S rRNA interaction site [nucleotide binding]; other site 509193001137 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 509193001138 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 509193001139 elongation factor G; Reviewed; Region: PRK00007 509193001140 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 509193001141 G1 box; other site 509193001142 putative GEF interaction site [polypeptide binding]; other site 509193001143 GTP/Mg2+ binding site [chemical binding]; other site 509193001144 Switch I region; other site 509193001145 G2 box; other site 509193001146 G3 box; other site 509193001147 Switch II region; other site 509193001148 G4 box; other site 509193001149 G5 box; other site 509193001150 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 509193001151 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 509193001152 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 509193001153 elongation factor Tu; Reviewed; Region: PRK00049 509193001154 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 509193001155 G1 box; other site 509193001156 GEF interaction site [polypeptide binding]; other site 509193001157 GTP/Mg2+ binding site [chemical binding]; other site 509193001158 Switch I region; other site 509193001159 G2 box; other site 509193001160 G3 box; other site 509193001161 Switch II region; other site 509193001162 G4 box; other site 509193001163 G5 box; other site 509193001164 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 509193001165 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 509193001166 Antibiotic Binding Site [chemical binding]; other site 509193001167 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 509193001168 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 509193001169 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 509193001170 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 509193001171 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 509193001172 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 509193001173 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 509193001174 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 509193001175 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 509193001176 putative translocon binding site; other site 509193001177 protein-rRNA interface [nucleotide binding]; other site 509193001178 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 509193001179 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 509193001180 G-X-X-G motif; other site 509193001181 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 509193001182 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 509193001183 23S rRNA interface [nucleotide binding]; other site 509193001184 5S rRNA interface [nucleotide binding]; other site 509193001185 putative antibiotic binding site [chemical binding]; other site 509193001186 L25 interface [polypeptide binding]; other site 509193001187 L27 interface [polypeptide binding]; other site 509193001188 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 509193001189 23S rRNA interface [nucleotide binding]; other site 509193001190 putative translocon interaction site; other site 509193001191 signal recognition particle (SRP54) interaction site; other site 509193001192 L23 interface [polypeptide binding]; other site 509193001193 trigger factor interaction site; other site 509193001194 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 509193001195 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 509193001196 KOW motif; Region: KOW; cl00354 509193001197 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 509193001198 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 509193001199 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 509193001200 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 509193001201 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 509193001202 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 509193001203 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509193001204 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 509193001205 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 509193001206 5S rRNA interface [nucleotide binding]; other site 509193001207 L27 interface [polypeptide binding]; other site 509193001208 23S rRNA interface [nucleotide binding]; other site 509193001209 L5 interface [polypeptide binding]; other site 509193001210 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 509193001211 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 509193001212 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 509193001213 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 509193001214 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 509193001215 SecY translocase; Region: SecY; pfam00344 509193001216 adenylate kinase; Reviewed; Region: adk; PRK00279 509193001217 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 509193001218 AMP-binding site [chemical binding]; other site 509193001219 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 509193001220 methionine aminopeptidase; Reviewed; Region: PRK07281 509193001221 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 509193001222 active site 509193001223 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 509193001224 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 509193001225 rRNA binding site [nucleotide binding]; other site 509193001226 predicted 30S ribosome binding site; other site 509193001227 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 509193001228 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 509193001229 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 509193001230 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 509193001231 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 509193001232 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 509193001233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509193001234 RNA binding surface [nucleotide binding]; other site 509193001235 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 509193001236 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 509193001237 alphaNTD homodimer interface [polypeptide binding]; other site 509193001238 alphaNTD - beta interaction site [polypeptide binding]; other site 509193001239 alphaNTD - beta' interaction site [polypeptide binding]; other site 509193001240 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 509193001241 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 509193001242 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 509193001243 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 509193001244 Walker A/P-loop; other site 509193001245 ATP binding site [chemical binding]; other site 509193001246 Q-loop/lid; other site 509193001247 ABC transporter signature motif; other site 509193001248 Walker B; other site 509193001249 D-loop; other site 509193001250 H-loop/switch region; other site 509193001251 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 509193001252 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 509193001253 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 509193001254 Walker A/P-loop; other site 509193001255 ATP binding site [chemical binding]; other site 509193001256 Q-loop/lid; other site 509193001257 ABC transporter signature motif; other site 509193001258 Walker B; other site 509193001259 D-loop; other site 509193001260 H-loop/switch region; other site 509193001261 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 509193001262 Cobalt transport protein; Region: CbiQ; cl00463 509193001263 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 509193001264 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 509193001265 dimerization interface 3.5A [polypeptide binding]; other site 509193001266 active site 509193001267 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 509193001268 23S rRNA interface [nucleotide binding]; other site 509193001269 L3 interface [polypeptide binding]; other site 509193001270 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 509193001271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509193001272 non-specific DNA binding site [nucleotide binding]; other site 509193001273 salt bridge; other site 509193001274 sequence-specific DNA binding site [nucleotide binding]; other site 509193001275 mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); Region: 3a0801s09; TIGR00990 509193001276 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 509193001277 TPR motif; other site 509193001278 binding surface 509193001279 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 509193001280 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193001281 Walker A/P-loop; other site 509193001282 ATP binding site [chemical binding]; other site 509193001283 Q-loop/lid; other site 509193001284 ABC transporter signature motif; other site 509193001285 Walker B; other site 509193001286 D-loop; other site 509193001287 H-loop/switch region; other site 509193001288 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 509193001289 Protein of unknown function (DUF990); Region: DUF990; cl01496 509193001290 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 509193001291 Protein of unknown function (DUF990); Region: DUF990; cl01496 509193001292 Radical SAM; Region: Elp3; smart00729 509193001293 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193001294 FeS/SAM binding site; other site 509193001295 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 509193001296 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193001297 FeS/SAM binding site; other site 509193001298 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 509193001299 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 509193001300 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193001301 Integrase core domain; Region: rve; cl01316 509193001302 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 509193001303 putative transposase OrfB; Reviewed; Region: PHA02517 509193001304 Integrase core domain; Region: rve; cl01316 509193001305 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl01116 509193001306 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 509193001307 diiron binding motif [ion binding]; other site 509193001308 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion...; Region: SORL_classII; cd03172 509193001309 non-heme iron binding site [ion binding]; other site 509193001310 tetramer interface [polypeptide binding]; other site 509193001311 Carbon starvation protein CstA; Region: CstA; cl00856 509193001312 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 509193001313 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 509193001314 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 509193001315 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 509193001316 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 509193001317 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 509193001318 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 509193001319 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 509193001320 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 509193001321 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07234 509193001322 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 509193001323 Transporter associated domain; Region: CorC_HlyC; pfam03471 509193001324 Thymidylate synthase complementing protein; Region: Thy1; cl03630 509193001325 Thymidylate synthase complementing protein; Region: Thy1; cl03630 509193001326 Coat F domain; Region: Coat_F; cl02368 509193001327 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 509193001328 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193001329 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193001330 putative peptidoglycan binding site; other site 509193001331 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509193001332 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193001333 putative peptidoglycan binding site; other site 509193001334 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193001335 putative peptidoglycan binding site; other site 509193001336 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193001337 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193001338 putative peptidoglycan binding site; other site 509193001339 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 509193001340 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 509193001341 active site 509193001342 metal binding site [ion binding]; metal-binding site 509193001343 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 509193001344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193001345 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193001346 motif II; other site 509193001347 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 509193001348 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 509193001349 MoxR-like ATPases [General function prediction only]; Region: COG0714 509193001350 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193001351 Walker A motif; other site 509193001352 ATP binding site [chemical binding]; other site 509193001353 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193001354 Walker B motif; other site 509193001355 arginine finger; other site 509193001356 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 509193001357 Ligand Binding Site [chemical binding]; other site 509193001358 BON domain; Region: BON; cl02771 509193001359 BON domain; Region: BON; cl02771 509193001360 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193001361 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193001362 Uncharacterized conserved protein [Function unknown]; Region: COG1624 509193001363 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 509193001364 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 509193001365 YbbR-like protein; Region: YbbR; pfam07949 509193001366 YbbR-like protein; Region: YbbR; pfam07949 509193001367 Acetokinase family; Region: Acetate_kinase; cl01029 509193001368 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 509193001369 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 509193001370 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 509193001371 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 509193001372 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 509193001373 NAD binding site [chemical binding]; other site 509193001374 Phe binding site; other site 509193001375 Acetokinase family; Region: Acetate_kinase; cl01029 509193001376 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 509193001377 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 509193001378 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 509193001379 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 509193001380 dimer interface [polypeptide binding]; other site 509193001381 PYR/PP interface [polypeptide binding]; other site 509193001382 TPP binding site [chemical binding]; other site 509193001383 substrate binding site [chemical binding]; other site 509193001384 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509193001385 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 509193001386 TPP-binding site [chemical binding]; other site 509193001387 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 509193001388 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 509193001389 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 509193001390 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 509193001391 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 509193001392 putative acyl-acceptor binding pocket; other site 509193001393 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 509193001394 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 509193001395 active site 509193001396 substrate binding site [chemical binding]; other site 509193001397 metal binding site [ion binding]; metal-binding site 509193001398 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 509193001399 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 509193001400 glutaminase active site [active] 509193001401 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 509193001402 dimer interface [polypeptide binding]; other site 509193001403 active site 509193001404 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 509193001405 dimer interface [polypeptide binding]; other site 509193001406 active site 509193001407 EamA-like transporter family; Region: EamA; cl01037 509193001408 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 509193001409 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 509193001410 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 509193001411 active site 509193001412 DNA binding site [nucleotide binding] 509193001413 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 509193001414 DNA binding site [nucleotide binding] 509193001415 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 509193001416 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 509193001417 putative DNA binding site [nucleotide binding]; other site 509193001418 putative homodimer interface [polypeptide binding]; other site 509193001419 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193001420 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193001421 putative peptidoglycan binding site; other site 509193001422 Beta-lactamase; Region: Beta-lactamase; cl01009 509193001423 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 509193001424 Protein of unknown function (DUF503); Region: DUF503; cl00669 509193001425 hybrid cluster protein; Provisional; Region: PRK05290 509193001426 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 509193001427 ACS interaction site; other site 509193001428 CODH interaction site; other site 509193001429 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 509193001430 hybrid metal cluster; other site 509193001431 transcriptional repressor DicA; Reviewed; Region: PRK09706 509193001432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509193001433 non-specific DNA binding site [nucleotide binding]; other site 509193001434 salt bridge; other site 509193001435 sequence-specific DNA binding site [nucleotide binding]; other site 509193001436 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 509193001437 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 509193001438 putative carbohydrate kinase; Provisional; Region: PRK10565 509193001439 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 509193001440 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 509193001441 putative substrate binding site [chemical binding]; other site 509193001442 putative ATP binding site [chemical binding]; other site 509193001443 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 509193001444 alanine racemase; Reviewed; Region: alr; PRK00053 509193001445 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 509193001446 active site 509193001447 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509193001448 dimer interface [polypeptide binding]; other site 509193001449 substrate binding site [chemical binding]; other site 509193001450 catalytic residues [active] 509193001451 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 509193001452 PemK-like protein; Region: PemK; cl00995 509193001453 Uncharacterized conserved protein [Function unknown]; Region: COG1284 509193001454 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 509193001455 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 509193001456 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 509193001457 TPP-binding site [chemical binding]; other site 509193001458 dimer interface [polypeptide binding]; other site 509193001459 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 509193001460 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509193001461 PYR/PP interface [polypeptide binding]; other site 509193001462 dimer interface [polypeptide binding]; other site 509193001463 TPP binding site [chemical binding]; other site 509193001464 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509193001465 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; cl01957 509193001466 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 509193001467 active site 509193001468 ADP/pyrophosphate binding site [chemical binding]; other site 509193001469 fructose-1,6-bisphosphate binding site; other site 509193001470 dimerization interface [polypeptide binding]; other site 509193001471 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 509193001472 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 509193001473 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 509193001474 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 509193001475 Ligand Binding Site [chemical binding]; other site 509193001476 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 509193001477 Rubredoxin; Region: Rubredoxin; pfam00301 509193001478 iron binding site [ion binding]; other site 509193001479 ThiC family; Region: ThiC; cl08031 509193001480 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193001481 Integrase core domain; Region: rve; cl01316 509193001482 Homoserine dehydrogenase [Amino acid transport and metabolism]; Region: ThrA; COG0460 509193001483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193001484 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 509193001485 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 509193001486 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 509193001487 homodimer interface [polypeptide binding]; other site 509193001488 substrate-cofactor binding pocket; other site 509193001489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193001490 catalytic residue [active] 509193001491 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509193001492 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 509193001493 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509193001494 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193001495 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 509193001496 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 509193001497 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193001498 S-adenosylmethionine binding site [chemical binding]; other site 509193001499 Uncharacterized conserved protein [Function unknown]; Region: COG3270 509193001500 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 509193001501 Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091 509193001502 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 509193001503 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 509193001504 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 509193001505 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 509193001506 Putative carbohydrate binding domain; Region: CBM_X; pfam06204 509193001507 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 509193001508 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 509193001509 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 509193001510 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193001511 Walker A/P-loop; other site 509193001512 ATP binding site [chemical binding]; other site 509193001513 Q-loop/lid; other site 509193001514 ABC transporter signature motif; other site 509193001515 Walker B; other site 509193001516 D-loop; other site 509193001517 H-loop/switch region; other site 509193001518 ABC-2 type transporter; Region: ABC2_membrane; cl11417 509193001519 gliding-associated putative ABC transporter substrate-binding component GldG; Region: GldG; TIGR03521 509193001520 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 509193001521 HEPN domain; Region: HEPN; cl00824 509193001522 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509193001523 active site 509193001524 NTP binding site [chemical binding]; other site 509193001525 metal binding triad [ion binding]; metal-binding site 509193001526 antibiotic binding site [chemical binding]; other site 509193001527 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 509193001528 putative active site [active] 509193001529 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 509193001530 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 509193001531 dimer interface [polypeptide binding]; other site 509193001532 motif 1; other site 509193001533 active site 509193001534 motif 2; other site 509193001535 motif 3; other site 509193001536 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193001537 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 509193001538 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 509193001539 NAD binding site [chemical binding]; other site 509193001540 dimerization interface [polypeptide binding]; other site 509193001541 product binding site; other site 509193001542 substrate binding site [chemical binding]; other site 509193001543 zinc binding site [ion binding]; other site 509193001544 catalytic residues [active] 509193001545 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 509193001546 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509193001547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193001548 homodimer interface [polypeptide binding]; other site 509193001549 catalytic residue [active] 509193001550 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 509193001551 putative active site pocket [active] 509193001552 4-fold oligomerization interface [polypeptide binding]; other site 509193001553 metal binding residues [ion binding]; metal-binding site 509193001554 3-fold/trimer interface [polypeptide binding]; other site 509193001555 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 509193001556 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 509193001557 putative active site [active] 509193001558 oxyanion strand; other site 509193001559 catalytic triad [active] 509193001560 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 509193001561 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 509193001562 catalytic residues [active] 509193001563 Imidazoleglycerol-phosphate synthase [Amino acid transport and metabolism]; Region: HisF; COG0107 509193001564 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 509193001565 substrate binding site [chemical binding]; other site 509193001566 glutamase interaction surface [polypeptide binding]; other site 509193001567 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 509193001568 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 509193001569 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 509193001570 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193001571 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193001572 putative active site [active] 509193001573 putative NTP binding site [chemical binding]; other site 509193001574 putative nucleic acid binding site [nucleotide binding]; other site 509193001575 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193001576 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 509193001577 dimer interface [polypeptide binding]; other site 509193001578 glycine-pyridoxal phosphate binding site [chemical binding]; other site 509193001579 active site 509193001580 folate binding site [chemical binding]; other site 509193001581 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 509193001582 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics...; Region: rDP_like; cd01301 509193001583 active site 509193001584 dimer interface [polypeptide binding]; other site 509193001585 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 509193001586 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 509193001587 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 509193001588 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 509193001589 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 509193001590 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 509193001591 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 509193001592 active site 509193001593 Substrate binding site [chemical binding]; other site 509193001594 Mg++ binding site [ion binding]; other site 509193001595 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 509193001596 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 509193001597 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2)...; Region: phosphohexomutase; cl03757 509193001598 active site 509193001599 substrate binding site [chemical binding]; other site 509193001600 metal binding site [ion binding]; metal-binding site 509193001601 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 509193001602 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 509193001603 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 509193001604 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 509193001605 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 509193001606 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-...; Region: MIP; cd00333 509193001607 amphipathic channel; other site 509193001608 Asn-Pro-Ala signature motifs; other site 509193001609 glycerol kinase; Provisional; Region: glpK; PRK00047 509193001610 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193001611 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 509193001612 Predicted dehydrogenase [General function prediction only]; Region: COG0579 509193001613 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl14881 509193001614 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 509193001615 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 509193001616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193001617 Protein of unknown function (DUF1667); Region: DUF1667; cl01591 509193001618 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 509193001619 dimerization domain swap beta strand [polypeptide binding]; other site 509193001620 regulatory protein interface [polypeptide binding]; other site 509193001621 active site 509193001622 regulatory phosphorylation site [posttranslational modification]; other site 509193001623 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 509193001624 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509193001625 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193001626 Walker A motif; other site 509193001627 ATP binding site [chemical binding]; other site 509193001628 Walker B motif; other site 509193001629 arginine finger; other site 509193001630 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 509193001631 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 509193001632 DAK2 domain; Region: Dak2; cl03685 509193001633 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 509193001634 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 509193001635 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193001636 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 509193001637 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 509193001638 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193001639 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 509193001640 Walker A motif; other site 509193001641 ATP binding site [chemical binding]; other site 509193001642 Walker B motif; other site 509193001643 arginine finger; other site 509193001644 Peptidase family M41; Region: Peptidase_M41; pfam01434 509193001645 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193001646 cell division protein FtsA; Region: ftsA; TIGR01174 509193001647 Cell division protein FtsA; Region: FtsA; cl11496 509193001648 Cell division protein FtsA; Region: FtsA; cl11496 509193001649 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509193001650 active site 509193001651 NTP binding site [chemical binding]; other site 509193001652 metal binding triad [ion binding]; metal-binding site 509193001653 antibiotic binding site [chemical binding]; other site 509193001654 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 509193001655 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193001656 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 509193001657 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193001658 motif II; other site 509193001659 Ribosomal_L25_TL5_CTC: Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain. L25 is a single-domain protein, homologous to the N-terminal domain of TL5 and CTC, which each contain two domains. CTC is a known stress protein, and proteins of this...; Region: Ribosomal_L25_TL5_CTC; cd00495 509193001660 5S rRNA interface [nucleotide binding]; other site 509193001661 CTC domain interface; other site 509193001662 L16 interface [polypeptide binding]; other site 509193001663 diaminopimelate decarboxylase; Region: lysA; TIGR01048 509193001664 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 509193001665 active site 509193001666 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509193001667 substrate binding site [chemical binding]; other site 509193001668 catalytic residues [active] 509193001669 dimer interface [polypeptide binding]; other site 509193001670 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 509193001671 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 509193001672 Walker A/P-loop; other site 509193001673 ATP binding site [chemical binding]; other site 509193001674 Q-loop/lid; other site 509193001675 ABC transporter signature motif; other site 509193001676 Walker B; other site 509193001677 D-loop; other site 509193001678 H-loop/switch region; other site 509193001679 TOBE domain; Region: TOBE_2; cl01440 509193001680 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 509193001681 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 509193001682 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division...; Region: ABC_FtsE_transporter; cd03292 509193001683 Walker A/P-loop; other site 509193001684 ATP binding site [chemical binding]; other site 509193001685 Q-loop/lid; other site 509193001686 ABC transporter signature motif; other site 509193001687 Walker B; other site 509193001688 D-loop; other site 509193001689 H-loop/switch region; other site 509193001690 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 509193001691 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 509193001692 Peptidase family M23; Region: Peptidase_M23; pfam01551 509193001693 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 509193001694 C-terminal peptidase (prc); Region: prc; TIGR00225 509193001695 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 509193001696 protein binding site [polypeptide binding]; other site 509193001697 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 509193001698 Catalytic dyad [active] 509193001699 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 509193001700 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 509193001701 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 509193001702 excinuclease ABC subunit B; Provisional; Region: PRK05298 509193001703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509193001704 ATP binding site [chemical binding]; other site 509193001705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509193001706 nucleotide binding region [chemical binding]; other site 509193001707 ATP-binding site [chemical binding]; other site 509193001708 Ultra-violet resistance protein B; Region: UvrB; pfam12344 509193001709 UvrB/uvrC motif; Region: UVR; pfam02151 509193001710 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 509193001711 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 509193001712 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 509193001713 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 509193001714 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 509193001715 phosphopeptide binding site; other site 509193001716 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 509193001717 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 509193001718 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509193001719 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 509193001720 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 509193001721 GIY-YIG catalytic domain; Region: GIY-YIG; cl01061 509193001722 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 509193001723 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 509193001724 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193001725 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 509193001726 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 509193001727 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 509193001728 HPr kinase/phosphorylase; Provisional; Region: PRK05428 509193001729 DRTGG domain; Region: DRTGG; cl12147 509193001730 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-...; Region: HprK_C; cd01918 509193001731 Hpr binding site; other site 509193001732 active site 509193001733 homohexamer subunit interaction site [polypeptide binding]; other site 509193001734 putative hydrolase; Validated; Region: PRK09248 509193001735 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 509193001736 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 509193001737 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193001738 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 509193001739 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 509193001740 Protein of unknown function, DUF624; Region: DUF624; cl02369 509193001741 hypothetical protein; Provisional; Region: PRK03881 509193001742 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 509193001743 AMMECR1; Region: AMMECR1; cl00911 509193001744 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 509193001745 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 509193001746 Phd_YefM; Region: PhdYeFM; cl09153 509193001747 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 509193001748 YcfA-like protein; Region: YcfA; cl00752 509193001749 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 509193001750 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 509193001751 DNA binding residues [nucleotide binding] 509193001752 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 509193001753 catalytic residues [active] 509193001754 catalytic nucleophile [active] 509193001755 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 509193001756 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 509193001757 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193001758 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193001759 DNA binding site [nucleotide binding] 509193001760 domain linker motif; other site 509193001761 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 509193001762 dimerization interface [polypeptide binding]; other site 509193001763 ligand binding site [chemical binding]; other site 509193001764 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509193001765 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193001766 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 509193001767 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 509193001768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193001769 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 509193001770 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 509193001771 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 509193001772 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 509193001773 AP (apurinic/apyrimidinic) site pocket; other site 509193001774 DNA interaction; other site 509193001775 Metal-binding active site; metal-binding site 509193001776 Membrane transport protein; Region: Mem_trans; cl09117 509193001777 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193001778 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193001779 glyoxylate reductase; Reviewed; Region: PRK13243 509193001780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193001781 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 509193001782 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193001783 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 509193001784 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 509193001785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193001786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193001787 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 509193001788 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 509193001789 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 509193001790 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193001791 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 509193001792 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 509193001793 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 509193001794 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 509193001795 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 509193001796 galactokinase; Provisional; Region: PRK05322 509193001797 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 509193001798 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 509193001799 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 509193001800 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 509193001801 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 509193001802 NAD binding site [chemical binding]; other site 509193001803 homodimer interface [polypeptide binding]; other site 509193001804 active site 509193001805 substrate binding site [chemical binding]; other site 509193001806 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193001807 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 509193001808 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193001809 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193001810 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine...; Region: URO-D_CIMS_like; cl00464 509193001811 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 509193001812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001813 dimer interface [polypeptide binding]; other site 509193001814 conserved gate region; other site 509193001815 putative PBP binding loops; other site 509193001816 ABC-ATPase subunit interface; other site 509193001817 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001818 dimer interface [polypeptide binding]; other site 509193001819 conserved gate region; other site 509193001820 putative PBP binding loops; other site 509193001821 ABC-ATPase subunit interface; other site 509193001822 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 509193001823 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-...; Region: GH31; cl11402 509193001824 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 509193001825 domain; Region: Glyco_hydro_2; pfam00703 509193001826 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 509193001827 Bacterial Ig-like domain (group 1); Region: Big_1; cl10510 509193001828 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 509193001829 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 509193001830 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 509193001831 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 509193001832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193001833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001834 dimer interface [polypeptide binding]; other site 509193001835 conserved gate region; other site 509193001836 putative PBP binding loops; other site 509193001837 ABC-ATPase subunit interface; other site 509193001838 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 509193001839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001840 dimer interface [polypeptide binding]; other site 509193001841 conserved gate region; other site 509193001842 putative PBP binding loops; other site 509193001843 ABC-ATPase subunit interface; other site 509193001844 Cupin domain; Region: Cupin_2; cl09118 509193001845 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 509193001846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 509193001847 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 509193001848 Sodium:neurotransmitter symporter family; Region: SNF; cl11976 509193001849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193001850 Walker A motif; other site 509193001851 ATP binding site [chemical binding]; other site 509193001852 Walker B motif; other site 509193001853 arginine finger; other site 509193001854 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 509193001855 active site 509193001856 intersubunit interactions; other site 509193001857 catalytic residue [active] 509193001858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193001859 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 509193001860 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509193001861 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 509193001862 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 509193001863 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193001864 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193001865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001866 dimer interface [polypeptide binding]; other site 509193001867 conserved gate region; other site 509193001868 putative PBP binding loops; other site 509193001869 ABC-ATPase subunit interface; other site 509193001870 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 509193001871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001872 dimer interface [polypeptide binding]; other site 509193001873 conserved gate region; other site 509193001874 putative PBP binding loops; other site 509193001875 ABC-ATPase subunit interface; other site 509193001876 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 509193001877 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 509193001878 substrate binding [chemical binding]; other site 509193001879 active site 509193001880 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 509193001881 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 509193001882 putative substrate binding site [chemical binding]; other site 509193001883 putative ATP binding site [chemical binding]; other site 509193001884 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193001885 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193001886 DNA binding site [nucleotide binding] 509193001887 domain linker motif; other site 509193001888 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 509193001889 dimerization interface [polypeptide binding]; other site 509193001890 ligand binding site [chemical binding]; other site 509193001891 sodium binding site [ion binding]; other site 509193001892 Predicted methyltransferases [General function prediction only]; Region: COG1568 509193001893 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 509193001894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193001895 S-adenosylmethionine binding site [chemical binding]; other site 509193001896 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 509193001897 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 509193001898 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 509193001899 switch II; other site 509193001900 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 509193001901 Ferredoxin [Energy production and conversion]; Region: COG1146 509193001902 switch II; other site 509193001903 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 509193001904 N-terminal domain; Region: tspaseT_teng_N; TIGR01765 509193001905 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 509193001906 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193001907 biotin synthase; Provisional; Region: PRK07094 509193001908 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193001909 FeS/SAM binding site; other site 509193001910 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 509193001911 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 509193001912 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193001913 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509193001914 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 509193001915 putative metal binding site [ion binding]; other site 509193001916 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 509193001917 ABC-ATPase subunit interface; other site 509193001918 dimer interface [polypeptide binding]; other site 509193001919 putative PBP binding regions; other site 509193001920 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 509193001921 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 509193001922 Walker A/P-loop; other site 509193001923 ATP binding site [chemical binding]; other site 509193001924 Q-loop/lid; other site 509193001925 ABC transporter signature motif; other site 509193001926 Walker B; other site 509193001927 D-loop; other site 509193001928 H-loop/switch region; other site 509193001929 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 509193001930 homodimer interaction site [polypeptide binding]; other site 509193001931 cofactor binding site; other site 509193001932 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 509193001933 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 509193001934 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 509193001935 Protein of unknown function (DUF1847); Region: DUF1847; cl02037 509193001936 ATP cone domain; Region: ATP-cone; pfam03477 509193001937 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 509193001938 Class III ribonucleotide reductase; Region: RNR_III; cd01675 509193001939 effector binding site; other site 509193001940 active site 509193001941 Zn binding site [ion binding]; other site 509193001942 glycine loop; other site 509193001943 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 509193001944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193001945 FeS/SAM binding site; other site 509193001946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cl01055 509193001947 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 509193001948 catalytic triad [active] 509193001949 conserved cis-peptide bond; other site 509193001950 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193001951 Integrase core domain; Region: rve; cl01316 509193001952 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 509193001953 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509193001954 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509193001955 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 509193001956 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 509193001957 active site 509193001958 nucleophile elbow; other site 509193001959 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 509193001960 FAD binding domain; Region: FAD_binding_4; pfam01565 509193001961 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 509193001962 putative hydrolase; Validated; Region: PRK09248 509193001963 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 509193001964 P-loop ATPase protein family; Region: ATP_bind_2; cl10035 509193001965 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 509193001966 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 509193001967 phosphate binding site [ion binding]; other site 509193001968 putative substrate binding pocket [chemical binding]; other site 509193001969 dimer interface [polypeptide binding]; other site 509193001970 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 509193001971 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 509193001972 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 509193001973 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 509193001974 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193001975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001976 dimer interface [polypeptide binding]; other site 509193001977 conserved gate region; other site 509193001978 putative PBP binding loops; other site 509193001979 ABC-ATPase subunit interface; other site 509193001980 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 509193001981 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193001982 dimer interface [polypeptide binding]; other site 509193001983 conserved gate region; other site 509193001984 putative PBP binding loops; other site 509193001985 ABC-ATPase subunit interface; other site 509193001986 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 509193001987 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 509193001988 Cgtase (cyclodextrin glycosyltransferase) C-terminus domain. Enzymes such as amylases, cyclomaltodextrinase (CDase), and CGTase degrade starch to smaller oligosaccharides by hydrolyzing the alpha-D-(1,4) linkages between glucose residues present in...; Region: CGTase_C_term; cd02849 509193001989 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20...; Region: CBM20; cd05467 509193001990 starch-binding site 2 [chemical binding]; other site 509193001991 starch-binding site 1 [chemical binding]; other site 509193001992 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 509193001993 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 509193001994 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 509193001995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 509193001996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 509193001997 maltodextrin glucosidase; Provisional; Region: PRK10785 509193001998 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 509193001999 homodimer; other site 509193002000 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 509193002001 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 509193002002 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 509193002003 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 509193002004 dimerization domain swap beta strand [polypeptide binding]; other site 509193002005 regulatory protein interface [polypeptide binding]; other site 509193002006 active site 509193002007 regulatory phosphorylation site [posttranslational modification]; other site 509193002008 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 509193002009 DRTGG domain; Region: DRTGG; cl12147 509193002010 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 509193002011 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 509193002012 active site 2 [active] 509193002013 active site 1 [active] 509193002014 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 509193002015 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 509193002016 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 509193002017 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 509193002018 generic binding surface II; other site 509193002019 generic binding surface I; other site 509193002020 6-phosphofructokinase; Provisional; Region: PRK03202 509193002021 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 509193002022 active site 509193002023 ADP/pyrophosphate binding site [chemical binding]; other site 509193002024 dimerization interface [polypeptide binding]; other site 509193002025 allosteric effector site; other site 509193002026 fructose-1,6-bisphosphate binding site; other site 509193002027 pyruvate kinase; Provisional; Region: PRK06354 509193002028 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 509193002029 domain interfaces; other site 509193002030 active site 509193002031 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 509193002032 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 509193002033 active site 509193002034 TRAM domain; Region: TRAM; cl01282 509193002035 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 509193002036 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193002037 S-adenosylmethionine binding site [chemical binding]; other site 509193002038 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 509193002039 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047 509193002040 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 509193002041 MatE; Region: MatE; pfam01554 509193002042 MatE; Region: MatE; pfam01554 509193002043 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 509193002044 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 509193002045 active site 509193002046 catalytic residues [active] 509193002047 metal binding site [ion binding]; metal-binding site 509193002048 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 509193002049 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 509193002050 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 509193002051 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509193002052 peptidase T; Region: peptidase-T; TIGR01882 509193002053 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 509193002054 metal binding site [ion binding]; metal-binding site 509193002055 dimer interface [polypeptide binding]; other site 509193002056 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 509193002057 putative FMN binding site [chemical binding]; other site 509193002058 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 509193002059 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 509193002060 active site 509193002061 dimer interface [polypeptide binding]; other site 509193002062 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 509193002063 dimer interface [polypeptide binding]; other site 509193002064 active site 509193002065 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 509193002066 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 509193002067 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 509193002068 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 509193002069 FAD binding site [chemical binding]; other site 509193002070 Homocysteine/selenocysteine methylase (S-methylmethionine-dependent) [Amino acid transport and metabolism]; Region: MHT1; cl14105 509193002071 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 509193002072 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 509193002073 Pterin binding enzyme; Region: Pterin_bind; pfam00809 509193002074 substrate binding pocket [chemical binding]; other site 509193002075 dimer interface [polypeptide binding]; other site 509193002076 inhibitor binding site; inhibition site 509193002077 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 509193002078 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 509193002079 B12 binding site [chemical binding]; other site 509193002080 cobalt ligand [ion binding]; other site 509193002081 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 509193002082 putative deacylase active site [active] 509193002083 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 509193002084 dimanganese center [ion binding]; other site 509193002085 CotJB protein; Region: CotJB; pfam12652 509193002086 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 509193002087 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 509193002088 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193002089 S-adenosylmethionine binding site [chemical binding]; other site 509193002090 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 509193002091 active site 509193002092 nucleophile elbow; other site 509193002093 Uncharacterized conserved protein [Function unknown]; Region: COG2128 509193002094 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 509193002095 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 509193002096 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 509193002097 active site 509193002098 Domain of unknown function (DUF205); Region: DUF205; cl00410 509193002099 HIRAN domain; Region: HIRAN; pfam08797 509193002100 recombination factor protein RarA; Reviewed; Region: PRK13342 509193002101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193002102 Walker A motif; other site 509193002103 ATP binding site [chemical binding]; other site 509193002104 Walker B motif; other site 509193002105 arginine finger; other site 509193002106 MgsA AAA+ ATPase C terminal; Region: MgsA_C; cl13440 509193002107 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 509193002108 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 509193002109 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 509193002110 active site 509193002111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 509193002112 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 509193002113 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 509193002114 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 509193002115 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 509193002116 Active site [active] 509193002117 Radical SAM; Region: Elp3; smart00729 509193002118 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193002119 FeS/SAM binding site; other site 509193002120 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 509193002121 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 509193002122 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 509193002123 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 509193002124 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 509193002125 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 509193002126 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 509193002127 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509193002128 minor groove reading motif; other site 509193002129 helix-hairpin-helix signature motif; other site 509193002130 active site 509193002131 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 509193002132 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 509193002133 VanW like protein; Region: VanW; pfam04294 509193002134 G5 domain; Region: G5; pfam07501 509193002135 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 509193002136 metal binding site 2 [ion binding]; metal-binding site 509193002137 putative DNA binding helix; other site 509193002138 metal binding site 1 [ion binding]; metal-binding site 509193002139 dimer interface [polypeptide binding]; other site 509193002140 structural Zn2+ binding site [ion binding]; other site 509193002141 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193002142 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 509193002143 active site 509193002144 motif I; other site 509193002145 motif II; other site 509193002146 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193002147 Acylphosphatase; Region: Acylphosphatase; cl00551 509193002148 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 509193002149 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 509193002150 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 509193002151 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 509193002152 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 509193002153 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 509193002154 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 509193002155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193002156 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 509193002157 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 509193002158 substrate binding site [chemical binding]; other site 509193002159 hinge regions; other site 509193002160 ADP binding site [chemical binding]; other site 509193002161 catalytic site [active] 509193002162 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 509193002163 substrate binding site [chemical binding]; other site 509193002164 dimer interface [polypeptide binding]; other site 509193002165 catalytic triad [active] 509193002166 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 509193002167 Sulfatase; Region: Sulfatase; cl10460 509193002168 enolase; Provisional; Region: eno; PRK00077 509193002169 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 509193002170 dimer interface [polypeptide binding]; other site 509193002171 metal binding site [ion binding]; metal-binding site 509193002172 substrate binding pocket [chemical binding]; other site 509193002173 Preprotein translocase SecG subunit; Region: SecG; cl09123 509193002174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193002175 Zn2+ binding site [ion binding]; other site 509193002176 Mg2+ binding site [ion binding]; other site 509193002177 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509193002178 DNA primase; Validated; Region: dnaG; PRK05667 509193002179 CHC2 zinc finger; Region: zf-CHC2; cl02597 509193002180 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 509193002181 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 509193002182 active site 509193002183 metal binding site [ion binding]; metal-binding site 509193002184 interdomain interaction site; other site 509193002185 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 509193002186 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 509193002187 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 509193002188 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 509193002189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193002190 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 509193002191 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 509193002192 DNA binding residues [nucleotide binding] 509193002193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193002194 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 509193002195 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 509193002196 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl01309 509193002197 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 509193002198 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 509193002199 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 509193002200 mannose-6-phosphate isomerase; Provisional; Region: PRK15131; cl14659 509193002201 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 509193002202 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 509193002203 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 509193002204 Predicted permease; Region: DUF318; cl00487 509193002205 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509193002206 dimerization interface [polypeptide binding]; other site 509193002207 putative DNA binding site [nucleotide binding]; other site 509193002208 putative Zn2+ binding site [ion binding]; other site 509193002209 dipeptidase PepV; Reviewed; Region: PRK07318 509193002210 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 509193002211 active site 509193002212 metal binding site [ion binding]; metal-binding site 509193002213 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 509193002214 GAF domain; Region: GAF; cl00853 509193002215 NifU-like domain; Region: NifU; cl00484 509193002216 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 509193002217 NAD+ binding site [chemical binding]; other site 509193002218 substrate binding site [chemical binding]; other site 509193002219 Zn binding site [ion binding]; other site 509193002220 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 509193002221 DNA-binding site [nucleotide binding]; DNA binding site 509193002222 RNA-binding motif; other site 509193002223 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 509193002224 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 509193002225 dimerization interface [polypeptide binding]; other site 509193002226 domain crossover interface; other site 509193002227 redox-dependent activation switch; other site 509193002228 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509193002229 catalytic residues [active] 509193002230 Response regulator receiver domain; Region: Response_reg; pfam00072 509193002231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193002232 active site 509193002233 phosphorylation site [posttranslational modification] 509193002234 intermolecular recognition site; other site 509193002235 dimerization interface [polypeptide binding]; other site 509193002236 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509193002237 metal binding site [ion binding]; metal-binding site 509193002238 active site 509193002239 I-site; other site 509193002240 YtxC-like family; Region: YtxC; cl08500 509193002241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 509193002242 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 509193002243 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 509193002244 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 509193002245 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 509193002246 active site 509193002247 dimer interface [polypeptide binding]; other site 509193002248 motif 1; other site 509193002249 motif 2; other site 509193002250 motif 3; other site 509193002251 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 509193002252 anticodon binding site; other site 509193002253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193002254 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 509193002255 Tetramer interface [polypeptide binding]; other site 509193002256 Active site [active] 509193002257 FMN-binding site [chemical binding]; other site 509193002258 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 509193002259 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 509193002260 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 509193002261 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 509193002262 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 509193002263 23S rRNA binding site [nucleotide binding]; other site 509193002264 L21 binding site [polypeptide binding]; other site 509193002265 L13 binding site [polypeptide binding]; other site 509193002266 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 509193002267 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 509193002268 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 509193002269 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 509193002270 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 509193002271 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 509193002272 dimer interface [polypeptide binding]; other site 509193002273 motif 1; other site 509193002274 active site 509193002275 motif 2; other site 509193002276 motif 3; other site 509193002277 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 509193002278 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 509193002279 putative tRNA-binding site [nucleotide binding]; other site 509193002280 B3/4 domain; Region: B3_4; cl11458 509193002281 tRNA synthetase B5 domain; Region: B5; cl08394 509193002282 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 509193002283 dimer interface [polypeptide binding]; other site 509193002284 motif 1; other site 509193002285 motif 3; other site 509193002286 motif 2; other site 509193002287 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 509193002288 Cell division protein ZapA; Region: ZapA; cl01146 509193002289 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 509193002290 Peptidase family U32; Region: Peptidase_U32; cl03113 509193002291 Collagenase; Region: DUF3656; pfam12392 509193002292 Peptidase family U32; Region: Peptidase_U32; cl03113 509193002293 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 509193002294 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 509193002295 Walker A/P-loop; other site 509193002296 ATP binding site [chemical binding]; other site 509193002297 Q-loop/lid; other site 509193002298 ABC transporter signature motif; other site 509193002299 Walker B; other site 509193002300 D-loop; other site 509193002301 H-loop/switch region; other site 509193002302 Smr domain; Region: Smr; cl02619 509193002303 Protein of unknown function (DUF523); Region: DUF523; cl00733 509193002304 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 509193002305 Sensor protein DegS; Region: DegS; pfam05384 509193002306 Histidine kinase; Region: HisKA_3; pfam07730 509193002307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 509193002308 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 509193002309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193002310 active site 509193002311 phosphorylation site [posttranslational modification] 509193002312 intermolecular recognition site; other site 509193002313 dimerization interface [polypeptide binding]; other site 509193002314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors...; Region: LuxR_C_like; cd06170 509193002315 DNA binding residues [nucleotide binding] 509193002316 dimerization interface [polypeptide binding]; other site 509193002317 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 509193002318 oligomer interface [polypeptide binding]; other site 509193002319 putative active site [active] 509193002320 metal binding site [ion binding]; metal-binding site 509193002321 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 509193002322 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 509193002323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193002324 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 509193002325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193002326 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509193002327 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 509193002328 lipoyl synthase; Provisional; Region: PRK05481 509193002329 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193002330 FeS/SAM binding site; other site 509193002331 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 509193002332 GAF domain; Region: GAF; cl00853 509193002333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193002334 Walker A motif; other site 509193002335 ATP binding site [chemical binding]; other site 509193002336 Walker B motif; other site 509193002337 arginine finger; other site 509193002338 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 509193002339 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 509193002340 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 509193002341 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 509193002342 tetramer interface [polypeptide binding]; other site 509193002343 TPP-binding site [chemical binding]; other site 509193002344 heterodimer interface [polypeptide binding]; other site 509193002345 phosphorylation loop region [posttranslational modification] 509193002346 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 509193002347 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 509193002348 alpha subunit interface [polypeptide binding]; other site 509193002349 TPP binding site [chemical binding]; other site 509193002350 heterodimer interface [polypeptide binding]; other site 509193002351 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509193002352 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 509193002353 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 509193002354 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509193002355 E3 interaction surface; other site 509193002356 lipoyl attachment site [posttranslational modification]; other site 509193002357 e3 binding domain; Region: E3_binding; pfam02817 509193002358 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 509193002359 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 509193002360 dinuclear metal binding motif [ion binding]; other site 509193002361 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 509193002362 putative homotetramer interface [polypeptide binding]; other site 509193002363 putative homodimer interface [polypeptide binding]; other site 509193002364 putative allosteric switch controlling residues; other site 509193002365 putative metal binding site [ion binding]; other site 509193002366 putative homodimer-homodimer interface [polypeptide binding]; other site 509193002367 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 509193002368 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509193002369 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509193002370 catalytic residue [active] 509193002371 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 509193002372 THUMP domain; Region: THUMP; cl12076 509193002373 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 509193002374 Ligand Binding Site [chemical binding]; other site 509193002375 Protein of unknown function(DUF2089); Region: DUF2089; pfam09862 509193002376 GTP-binding protein YchF; Reviewed; Region: PRK09601 509193002377 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 509193002378 G1 box; other site 509193002379 GTP/Mg2+ binding site [chemical binding]; other site 509193002380 Switch I region; other site 509193002381 G2 box; other site 509193002382 Switch II region; other site 509193002383 G3 box; other site 509193002384 G4 box; other site 509193002385 G5 box; other site 509193002386 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 509193002387 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 509193002388 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509193002389 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509193002390 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509193002391 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509193002392 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509193002393 cell division protein MraZ; Reviewed; Region: PRK00326 509193002394 MraZ protein; Region: MraZ; pfam02381 509193002395 MraZ protein; Region: MraZ; pfam02381 509193002396 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 509193002397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193002398 Septum formation initiator; Region: DivIC; cl11433 509193002399 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 509193002400 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509193002401 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 509193002402 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 509193002403 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 509193002404 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 509193002405 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509193002406 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193002407 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509193002408 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 509193002409 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 509193002410 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193002411 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509193002412 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 509193002413 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 509193002414 Mg++ binding site [ion binding]; other site 509193002415 putative catalytic motif [active] 509193002416 putative substrate binding site [chemical binding]; other site 509193002417 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 509193002418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193002419 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193002420 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509193002421 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 509193002422 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 509193002423 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 509193002424 active site 509193002425 homodimer interface [polypeptide binding]; other site 509193002426 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 509193002427 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 509193002428 hinge; other site 509193002429 active site 509193002430 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 509193002431 Cell division protein FtsQ; Region: FtsQ; pfam03799 509193002432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 509193002433 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 509193002434 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 509193002435 cell division protein FtsA; Region: ftsA; TIGR01174 509193002436 Cell division protein FtsA; Region: FtsA; cl11496 509193002437 Cell division protein FtsA; Region: FtsA; cl11496 509193002438 cell division protein FtsZ; Validated; Region: PRK09330 509193002439 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 509193002440 nucleotide binding site [chemical binding]; other site 509193002441 SulA interaction site; other site 509193002442 Sporulation factor SpoIIGA; Region: Peptidase_U4; cl04058 509193002443 sporulation sigma factor SigE; Reviewed; Region: PRK08301 509193002444 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193002445 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 509193002446 DNA binding residues [nucleotide binding] 509193002447 sporulation sigma factor SigG; Reviewed; Region: PRK08215 509193002448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193002449 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 509193002450 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 509193002451 DNA binding residues [nucleotide binding] 509193002452 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 509193002453 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 509193002454 ATP cone domain; Region: ATP-cone; pfam03477 509193002455 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 509193002456 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193002457 active site 509193002458 phosphorylation site [posttranslational modification] 509193002459 intermolecular recognition site; other site 509193002460 dimerization interface [polypeptide binding]; other site 509193002461 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 509193002462 DNA binding site [nucleotide binding] 509193002463 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 509193002464 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 509193002465 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509193002466 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 509193002467 dimer interface [polypeptide binding]; other site 509193002468 phosphorylation site [posttranslational modification] 509193002469 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193002470 ATP binding site [chemical binding]; other site 509193002471 Mg2+ binding site [ion binding]; other site 509193002472 G-X-G motif; other site 509193002473 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193002474 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 509193002475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193002476 dimer interface [polypeptide binding]; other site 509193002477 conserved gate region; other site 509193002478 putative PBP binding loops; other site 509193002479 ABC-ATPase subunit interface; other site 509193002480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193002481 dimer interface [polypeptide binding]; other site 509193002482 conserved gate region; other site 509193002483 putative PBP binding loops; other site 509193002484 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590 509193002485 ABC-ATPase subunit interface; other site 509193002486 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 509193002487 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 509193002488 Walker A/P-loop; other site 509193002489 ATP binding site [chemical binding]; other site 509193002490 Q-loop/lid; other site 509193002491 ABC transporter signature motif; other site 509193002492 Walker B; other site 509193002493 D-loop; other site 509193002494 H-loop/switch region; other site 509193002495 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 509193002496 PhoU domain; Region: PhoU; pfam01895 509193002497 PhoU domain; Region: PhoU; pfam01895 509193002498 Protein of unknown function (DUF1614); Region: DUF1614; cl01694 509193002499 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 509193002500 stage II sporulation protein P; Region: spore_II_P; TIGR02867 509193002501 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 509193002502 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 509193002503 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 509193002504 Protein of unknown function (DUF512); Region: DUF512; pfam04459 509193002505 GTP-binding protein Der; Reviewed; Region: PRK00093 509193002506 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 509193002507 G1 box; other site 509193002508 GTP/Mg2+ binding site [chemical binding]; other site 509193002509 Switch I region; other site 509193002510 G2 box; other site 509193002511 Switch II region; other site 509193002512 G3 box; other site 509193002513 G4 box; other site 509193002514 G5 box; other site 509193002515 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 509193002516 G1 box; other site 509193002517 GTP/Mg2+ binding site [chemical binding]; other site 509193002518 Switch I region; other site 509193002519 G2 box; other site 509193002520 G3 box; other site 509193002521 Switch II region; other site 509193002522 G4 box; other site 509193002523 G5 box; other site 509193002524 Domain of unknown function (DUF205); Region: DUF205; cl00410 509193002525 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 509193002526 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193002527 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 509193002528 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 509193002529 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 509193002530 N subunit; Region: benz_CoA_bzdN; cl11464 509193002531 N subunit; Region: benz_CoA_bzdN; cl11464 509193002532 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 509193002533 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 509193002534 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193002535 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 509193002536 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 509193002537 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193002538 Integrase core domain; Region: rve; cl01316 509193002539 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 509193002540 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 509193002541 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 509193002542 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 509193002543 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193002544 FeS/SAM binding site; other site 509193002545 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 509193002546 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 509193002547 MoaE interaction surface [polypeptide binding]; other site 509193002548 MoeB interaction surface [polypeptide binding]; other site 509193002549 thiocarboxylated glycine; other site 509193002550 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 509193002551 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 509193002552 ATP binding site [chemical binding]; other site 509193002553 substrate interface [chemical binding]; other site 509193002554 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 509193002555 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa...; Region: MobB; cd03116 509193002556 Walker A motif; other site 509193002557 Putative Fe-S cluster; Region: FeS; pfam04060 509193002558 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 509193002559 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 509193002560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 509193002561 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 509193002562 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 509193002563 Walker A/P-loop; other site 509193002564 ATP binding site [chemical binding]; other site 509193002565 Q-loop/lid; other site 509193002566 ABC transporter signature motif; other site 509193002567 Walker B; other site 509193002568 D-loop; other site 509193002569 H-loop/switch region; other site 509193002570 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 509193002571 MPT binding site; other site 509193002572 trimer interface [polypeptide binding]; other site 509193002573 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 509193002574 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 509193002575 dimer interface [polypeptide binding]; other site 509193002576 putative functional site; other site 509193002577 putative MPT binding site; other site 509193002578 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 509193002579 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 509193002580 dimer interface [polypeptide binding]; other site 509193002581 putative functional site; other site 509193002582 putative MPT binding site; other site 509193002583 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193002584 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 509193002585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193002586 FeS/SAM binding site; other site 509193002587 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 509193002588 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 509193002589 trimer interface [polypeptide binding]; other site 509193002590 dimer interface [polypeptide binding]; other site 509193002591 putative active site [active] 509193002592 MOSC domain; Region: MOSC; pfam03473 509193002593 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 509193002594 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 509193002595 homotrimer interaction site [polypeptide binding]; other site 509193002596 putative active site [active] 509193002597 HlyD family secretion protein; Region: HlyD_2; pfam12700 509193002598 putative membrane fusion protein; Region: TIGR02828 509193002599 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 509193002600 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509193002601 catalytic residue [active] 509193002602 Protein of unknown function (DUF552); Region: DUF552; cl00775 509193002603 YGGT family; Region: YGGT; cl00508 509193002604 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 509193002605 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 509193002606 DivIVA protein; Region: DivIVA; pfam05103 509193002607 DivIVA domain; Region: DivI1A_domain; TIGR03544 509193002608 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 509193002609 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 509193002610 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 509193002611 HIGH motif; other site 509193002612 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 509193002613 active site 509193002614 KMSKS motif; other site 509193002615 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 509193002616 tRNA binding surface [nucleotide binding]; other site 509193002617 anticodon binding site; other site 509193002618 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 509193002619 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 509193002620 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 509193002621 active site 509193002622 putative substrate binding pocket [chemical binding]; other site 509193002623 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 509193002624 intersubunit interface [polypeptide binding]; other site 509193002625 active site 509193002626 Zn2+ binding site [ion binding]; other site 509193002627 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 509193002628 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509193002629 DNA-binding site [nucleotide binding]; DNA binding site 509193002630 UTRA domain; Region: UTRA; cl06649 509193002631 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 509193002632 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 509193002633 putative NAD(P) binding site [chemical binding]; other site 509193002634 catalytic Zn binding site [ion binding]; other site 509193002635 structural Zn binding site [ion binding]; other site 509193002636 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 509193002637 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 509193002638 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 509193002639 Walker A/P-loop; other site 509193002640 ATP binding site [chemical binding]; other site 509193002641 Q-loop/lid; other site 509193002642 ABC transporter signature motif; other site 509193002643 Walker B; other site 509193002644 D-loop; other site 509193002645 H-loop/switch region; other site 509193002646 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 509193002647 Walker A/P-loop; other site 509193002648 ATP binding site [chemical binding]; other site 509193002649 Q-loop/lid; other site 509193002650 ABC transporter signature motif; other site 509193002651 Walker B; other site 509193002652 D-loop; other site 509193002653 H-loop/switch region; other site 509193002654 Cobalt transport protein; Region: CbiQ; cl00463 509193002655 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 509193002656 QueT transporter; Region: QueT; cl01932 509193002657 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 509193002658 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 509193002659 homodimer interface [polypeptide binding]; other site 509193002660 substrate-cofactor binding pocket; other site 509193002661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193002662 catalytic residue [active] 509193002663 Domain of unknown function DUF77; Region: DUF77; cl00307 509193002664 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 509193002665 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 509193002666 putative active site [active] 509193002667 putative metal binding site [ion binding]; other site 509193002668 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193002669 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193002670 putative active site [active] 509193002671 putative NTP binding site [chemical binding]; other site 509193002672 putative nucleic acid binding site [nucleotide binding]; other site 509193002673 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193002674 anthranilate synthase component I; Provisional; Region: PRK13570 509193002675 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 509193002676 chorismate binding enzyme; Region: Chorismate_bind; cl10555 509193002677 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 509193002678 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 509193002679 glutamine binding [chemical binding]; other site 509193002680 catalytic triad [active] 509193002681 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 509193002682 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 509193002683 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 509193002684 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 509193002685 active site 509193002686 substrate (anthranilate) binding pocket [chemical binding]; other site 509193002687 product (indole) binding pocket [chemical binding]; other site 509193002688 ribulose/triose binding site [chemical binding]; other site 509193002689 phosphate binding site [ion binding]; other site 509193002690 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 509193002691 active site 509193002692 tryptophan synthase, beta chain; Region: PLN02618 509193002693 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 509193002694 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193002695 catalytic residue [active] 509193002696 tryptophan synthase; Region: PLN02591 509193002697 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 509193002698 substrate binding site [chemical binding]; other site 509193002699 active site 509193002700 catalytic residues [active] 509193002701 heterodimer interface [polypeptide binding]; other site 509193002702 NeuB family; Region: NeuB; cl00496 509193002703 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 509193002704 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by...; Region: PRX_BCP; cd03017 509193002705 catalytic triad [active] 509193002706 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 509193002707 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 509193002708 homodimer interface [polypeptide binding]; other site 509193002709 substrate-cofactor binding pocket; other site 509193002710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193002711 catalytic residue [active] 509193002712 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 509193002713 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 509193002714 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 509193002715 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 509193002716 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen...; Region: MM_CoA_mut_B12_BD; cd02071 509193002717 B12 binding site [chemical binding]; other site 509193002718 cobalt ligand [ion binding]; other site 509193002719 Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703 509193002720 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 509193002721 Walker A; other site 509193002722 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 509193002723 dimer interface [polypeptide binding]; other site 509193002724 substrate binding site [chemical binding]; other site 509193002725 metal binding site [ion binding]; metal-binding site 509193002726 subunit; Region: OAD_beta; cl00816 509193002727 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 509193002728 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193002729 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 509193002730 dimer interface [polypeptide binding]; other site 509193002731 FMN binding site [chemical binding]; other site 509193002732 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 509193002733 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509193002734 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 509193002735 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193002736 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193002737 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09732 509193002738 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl14784 509193002739 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817 509193002740 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 509193002741 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 509193002742 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 509193002743 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 509193002744 CRISPR-associated protein, TIGR03984 family; Region: TIGR03984 509193002745 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 509193002746 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 509193002747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509193002748 ATP binding site [chemical binding]; other site 509193002749 putative Mg++ binding site [ion binding]; other site 509193002750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509193002751 nucleotide binding region [chemical binding]; other site 509193002752 ATP-binding site [chemical binding]; other site 509193002753 Uncharacterized conserved protein [Function unknown]; Region: COG2433 509193002754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193002755 DNA-directed RNA polymerase subunit A'; Region: RNA_pol_rpoA1; TIGR02390 509193002756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193002757 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 509193002758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509193002759 ATP binding site [chemical binding]; other site 509193002760 putative Mg++ binding site [ion binding]; other site 509193002761 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509193002762 nucleotide binding region [chemical binding]; other site 509193002763 ATP-binding site [chemical binding]; other site 509193002764 PglZ domain; Region: PglZ; pfam08665 509193002765 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 509193002766 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193002767 Integrase core domain; Region: rve; cl01316 509193002768 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 509193002769 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509193002770 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509193002771 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193002772 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193002773 Walker A/P-loop; other site 509193002774 ATP binding site [chemical binding]; other site 509193002775 Q-loop/lid; other site 509193002776 ABC transporter signature motif; other site 509193002777 Walker B; other site 509193002778 D-loop; other site 509193002779 H-loop/switch region; other site 509193002780 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509193002781 non-specific DNA binding site [nucleotide binding]; other site 509193002782 salt bridge; other site 509193002783 sequence-specific DNA binding site [nucleotide binding]; other site 509193002784 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 509193002785 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509193002786 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 509193002787 Walker A/P-loop; other site 509193002788 ATP binding site [chemical binding]; other site 509193002789 Q-loop/lid; other site 509193002790 ABC transporter signature motif; other site 509193002791 Walker B; other site 509193002792 D-loop; other site 509193002793 H-loop/switch region; other site 509193002794 CLI_3235-class bacteriocin maturation radical SAM enzyme; Region: rSAM_ocin_clost; TIGR04068 509193002795 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 509193002796 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 509193002797 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509193002798 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193002799 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193002800 Walker A/P-loop; other site 509193002801 ATP binding site [chemical binding]; other site 509193002802 Q-loop/lid; other site 509193002803 ABC transporter signature motif; other site 509193002804 Walker B; other site 509193002805 D-loop; other site 509193002806 H-loop/switch region; other site 509193002807 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193002808 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 509193002809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193002810 FeS/SAM binding site; other site 509193002811 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 509193002812 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193002813 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193002814 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509193002815 Walker A/P-loop; other site 509193002816 ATP binding site [chemical binding]; other site 509193002817 Q-loop/lid; other site 509193002818 ABC transporter signature motif; other site 509193002819 Walker B; other site 509193002820 D-loop; other site 509193002821 H-loop/switch region; other site 509193002822 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509193002823 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193002824 Walker A/P-loop; other site 509193002825 ATP binding site [chemical binding]; other site 509193002826 Q-loop/lid; other site 509193002827 ABC transporter signature motif; other site 509193002828 Walker B; other site 509193002829 D-loop; other site 509193002830 H-loop/switch region; other site 509193002831 Protein of unknown function (DUF969); Region: DUF969; cl01573 509193002832 Protein of unknown function (DUF979); Region: DUF979; cl01572 509193002833 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 509193002834 putative substrate binding pocket [chemical binding]; other site 509193002835 AC domain interface; other site 509193002836 catalytic triad [active] 509193002837 AB domain interface; other site 509193002838 interchain disulfide; other site 509193002839 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509193002840 ligand binding site [chemical binding]; other site 509193002841 flexible hinge region; other site 509193002842 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 509193002843 proposed catalytic triad [active] 509193002844 conserved cys residue [active] 509193002845 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as...; Region: OYE_like_FMN_family; cd02803 509193002846 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 509193002847 active site 509193002848 FMN binding site [chemical binding]; other site 509193002849 substrate binding site [chemical binding]; other site 509193002850 putative catalytic residue [active] 509193002851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193002852 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193002853 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 509193002854 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193002855 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193002856 putative active site [active] 509193002857 putative NTP binding site [chemical binding]; other site 509193002858 putative nucleic acid binding site [nucleotide binding]; other site 509193002859 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193002860 Peptidase family M48; Region: Peptidase_M48; cl12018 509193002861 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 509193002862 Radical SAM; Region: Elp3; smart00729 509193002863 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193002864 FeS/SAM binding site; other site 509193002865 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 509193002866 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 509193002867 active site 509193002868 catalytic site [active] 509193002869 metal binding site [ion binding]; metal-binding site 509193002870 dimer interface [polypeptide binding]; other site 509193002871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193002872 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509193002873 putative substrate translocation pore; other site 509193002874 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 509193002875 putative ADP-ribose binding site [chemical binding]; other site 509193002876 putative active site [active] 509193002877 Bacitracin resistance protein BacA; Region: BacA; cl00858 509193002878 small acid-soluble spore protein SspI; Provisional; Region: PRK02955; cl07940 509193002879 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 509193002880 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 509193002881 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193002882 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509193002883 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509193002884 Active site [active] 509193002885 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 509193002886 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193002887 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 509193002888 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 509193002889 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 509193002890 Putative cyclase; Region: Cyclase; cl00814 509193002891 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 509193002892 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 509193002893 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 509193002894 putative L-serine binding site [chemical binding]; other site 509193002895 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 509193002896 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 509193002897 oligoendopeptidase F; Region: pepF; TIGR00181 509193002898 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 509193002899 active site 509193002900 Zn binding site [ion binding]; other site 509193002901 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 509193002902 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 509193002903 active site 509193002904 dimer interface [polypeptide binding]; other site 509193002905 metal binding site [ion binding]; metal-binding site 509193002906 prephenate dehydratase; Provisional; Region: PRK11898 509193002907 Prephenate dehydratase; Region: PDT; pfam00800 509193002908 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 509193002909 putative L-Phe binding site [chemical binding]; other site 509193002910 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 509193002911 NeuB family; Region: NeuB; cl00496 509193002912 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 509193002913 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193002914 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 509193002915 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 509193002916 hinge; other site 509193002917 active site 509193002918 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 509193002919 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193002920 putative peptidoglycan binding site; other site 509193002921 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 509193002922 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193002923 putative peptidoglycan binding site; other site 509193002924 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 509193002925 Predicted membrane protein [Function unknown]; Region: COG2119 509193002926 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509193002927 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 509193002928 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 509193002929 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193002930 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 509193002931 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193002932 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193002933 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination...; Region: GlcN6P_deaminase; cd01399 509193002934 active site 509193002935 trimer interface [polypeptide binding]; other site 509193002936 allosteric site; other site 509193002937 active site lid [active] 509193002938 hexamer (dimer of trimers) interface [polypeptide binding]; other site 509193002939 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 509193002940 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 509193002941 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 509193002942 catalytic residues [active] 509193002943 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509193002944 catalytic residues [active] 509193002945 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 509193002946 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 509193002947 homodimer interface [polypeptide binding]; other site 509193002948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193002949 catalytic residue [active] 509193002950 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 509193002951 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 509193002952 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509193002953 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 509193002954 catalytic loop [active] 509193002955 iron binding site [ion binding]; other site 509193002956 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 509193002957 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193002958 Walker A/P-loop; other site 509193002959 ATP binding site [chemical binding]; other site 509193002960 Q-loop/lid; other site 509193002961 ABC transporter signature motif; other site 509193002962 Walker B; other site 509193002963 D-loop; other site 509193002964 H-loop/switch region; other site 509193002965 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193002966 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193002967 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193002968 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193002969 Stage II sporulation protein; Region: SpoIID; cl07201 509193002970 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 509193002971 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 509193002972 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 509193002973 G1 box; other site 509193002974 GTP/Mg2+ binding site [chemical binding]; other site 509193002975 Switch I region; other site 509193002976 G2 box; other site 509193002977 G3 box; other site 509193002978 Switch II region; other site 509193002979 G4 box; other site 509193002980 G5 box; other site 509193002981 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 509193002982 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 509193002983 active site 509193002984 Ap6A binding site [chemical binding]; other site 509193002985 nudix motif; other site 509193002986 metal binding site [ion binding]; metal-binding site 509193002987 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 509193002988 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 509193002989 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 509193002990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193002991 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509193002992 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 509193002993 cysteine synthases; Region: cysKM; TIGR01136 509193002994 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 509193002995 dimer interface [polypeptide binding]; other site 509193002996 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193002997 catalytic residue [active] 509193002998 Domain of unknown function DUF28; Region: DUF28; cl00361 509193002999 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 509193003000 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 509193003001 active site 509193003002 putative DNA-binding cleft [nucleotide binding]; other site 509193003003 dimer interface [polypeptide binding]; other site 509193003004 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 509193003005 RuvA N terminal domain; Region: RuvA_N; pfam01330 509193003006 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 509193003007 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 509193003008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193003009 Walker A motif; other site 509193003010 ATP binding site [chemical binding]; other site 509193003011 Walker B motif; other site 509193003012 arginine finger; other site 509193003013 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 509193003014 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 509193003015 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 509193003016 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 509193003017 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 509193003018 Preprotein translocase subunit; Region: YajC; cl00806 509193003019 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 509193003020 rSAM-modified six-cysteine peptide SCIFF; Region: six_Cys_in_45; TIGR03973 509193003021 six-Cys-in-45 modification radical SAM protein; Region: rSAM_six_Cys; TIGR03974 509193003022 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 509193003023 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 509193003024 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 509193003025 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 509193003026 trimer interface [polypeptide binding]; other site 509193003027 putative metal binding site [ion binding]; other site 509193003028 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 509193003029 Protein export membrane protein; Region: SecD_SecF; cl14618 509193003030 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 509193003031 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 509193003032 Protein export membrane protein; Region: SecD_SecF; cl14618 509193003033 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 509193003034 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509193003035 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 509193003036 active site 509193003037 ATP binding site [chemical binding]; other site 509193003038 substrate binding site [chemical binding]; other site 509193003039 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 509193003040 DHH family; Region: DHH; pfam01368 509193003041 DHHA1 domain; Region: DHHA1; pfam02272 509193003042 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 509193003043 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193003044 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 509193003045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509193003046 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 509193003047 synthetase active site [active] 509193003048 NTP binding site [chemical binding]; other site 509193003049 metal binding site [ion binding]; metal-binding site 509193003050 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 509193003051 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 509193003052 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 509193003053 putative active site [active] 509193003054 dimerization interface [polypeptide binding]; other site 509193003055 putative tRNAtyr binding site [nucleotide binding]; other site 509193003056 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193003057 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 509193003058 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509193003059 FtsX-like permease family; Region: FtsX; pfam02687 509193003060 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509193003061 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 509193003062 Walker A/P-loop; other site 509193003063 ATP binding site [chemical binding]; other site 509193003064 Q-loop/lid; other site 509193003065 ABC transporter signature motif; other site 509193003066 Walker B; other site 509193003067 D-loop; other site 509193003068 H-loop/switch region; other site 509193003069 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509193003070 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 509193003071 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193003072 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 509193003073 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 509193003074 dimer interface [polypeptide binding]; other site 509193003075 motif 1; other site 509193003076 active site 509193003077 motif 2; other site 509193003078 motif 3; other site 509193003079 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 509193003080 anticodon binding site; other site 509193003081 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 509193003082 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 509193003083 dimer interface [polypeptide binding]; other site 509193003084 anticodon binding site; other site 509193003085 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 509193003086 homodimer interface [polypeptide binding]; other site 509193003087 motif 1; other site 509193003088 active site 509193003089 motif 2; other site 509193003090 GAD domain; Region: GAD; pfam02938 509193003091 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 509193003092 motif 3; other site 509193003093 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 509193003094 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-...; Region: YgdL_like; cd00755 509193003095 putative ATP binding site [chemical binding]; other site 509193003096 putative substrate interface [chemical binding]; other site 509193003097 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 509193003098 putative homotetramer interface [polypeptide binding]; other site 509193003099 putative homodimer interface [polypeptide binding]; other site 509193003100 putative allosteric switch controlling residues; other site 509193003101 putative metal binding site [ion binding]; other site 509193003102 putative homodimer-homodimer interface [polypeptide binding]; other site 509193003103 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 509193003104 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509193003105 catalytic residues [active] 509193003106 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 509193003107 catalytic residues [active] 509193003108 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 509193003109 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193003110 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 509193003111 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD)...; Region: Trp-synth-beta_II; cd00640 509193003112 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509193003113 catalytic residue [active] 509193003114 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 509193003115 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 509193003116 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine...; Region: B12-binding; cd02067 509193003117 B12 binding site [chemical binding]; other site 509193003118 cobalt ligand [ion binding]; other site 509193003119 conserved hypothetical protein; Region: glmL_fam; TIGR01319 509193003120 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 509193003121 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 509193003122 dimer interface [polypeptide binding]; other site 509193003123 active site 509193003124 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 509193003125 substrate binding site [chemical binding]; other site 509193003126 catalytic residue [active] 509193003127 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 509193003128 active site 509193003129 metal binding site [ion binding]; metal-binding site 509193003130 Predicted transcriptional regulator [Transcription]; Region: COG1959 509193003131 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193003132 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 509193003133 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 509193003134 Ligand Binding Site [chemical binding]; other site 509193003135 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 509193003136 Domain of unknown function DUF20; Region: UPF0118; cl00465 509193003137 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 509193003138 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 509193003139 motif 1; other site 509193003140 active site 509193003141 motif 2; other site 509193003142 motif 3; other site 509193003143 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509193003144 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 509193003145 DHHA1 domain; Region: DHHA1; pfam02272 509193003146 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 509193003147 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 509193003148 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 509193003149 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 509193003150 metal binding site 2 [ion binding]; metal-binding site 509193003151 putative DNA binding helix; other site 509193003152 metal binding site 1 [ion binding]; metal-binding site 509193003153 dimer interface [polypeptide binding]; other site 509193003154 structural Zn2+ binding site [ion binding]; other site 509193003155 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 509193003156 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193003157 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 509193003158 Protein of unknown function (DUF964); Region: DUF964; cl01483 509193003159 QueT transporter; Region: QueT; cl01932 509193003160 YceG-like family; Region: YceG; pfam02618 509193003161 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 509193003162 dimerization interface [polypeptide binding]; other site 509193003163 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193003164 S-adenosylmethionine binding site [chemical binding]; other site 509193003165 putative protease; Provisional; Region: PRK15452 509193003166 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 509193003167 Peptidase family U32; Region: Peptidase_U32; cl03113 509193003168 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 509193003169 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509193003170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 509193003171 sporulation sigma factor SigK; Reviewed; Region: PRK05803 509193003172 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193003173 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 509193003174 DNA binding residues [nucleotide binding] 509193003175 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193003176 active site 509193003177 motif I; other site 509193003178 motif II; other site 509193003179 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 509193003180 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 509193003181 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 509193003182 shikimate binding site; other site 509193003183 NAD(P) binding site [chemical binding]; other site 509193003184 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 509193003185 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 509193003186 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 509193003187 Walker A motif; other site 509193003188 ATP binding site [chemical binding]; other site 509193003189 Walker B motif; other site 509193003190 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 509193003191 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193003192 Walker A motif; other site 509193003193 ATP binding site [chemical binding]; other site 509193003194 Walker B motif; other site 509193003195 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 509193003196 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 509193003197 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 509193003198 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 509193003199 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 509193003200 general secretion pathway protein I; Region: gspI; TIGR01707 509193003201 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 509193003202 Late competence development protein ComFB; Region: ComFB; pfam10719 509193003203 Cell division protein FtsA; Region: FtsA; cl11496 509193003204 Cell division protein FtsA; Region: FtsA; cl11496 509193003205 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 509193003206 Pilus assembly protein, PilO; Region: PilO; cl01234 509193003207 shikimate kinase; Reviewed; Region: aroK; PRK00131 509193003208 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 509193003209 ADP binding site [chemical binding]; other site 509193003210 magnesium binding site [ion binding]; other site 509193003211 putative shikimate binding site; other site 509193003212 AP endonuclease family 2; Region: AP2Ec; smart00518 509193003213 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 509193003214 AP (apurinic/apyrimidinic) site pocket; other site 509193003215 DNA interaction; other site 509193003216 Metal-binding active site; metal-binding site 509193003217 gamma-glutamyl kinase; Provisional; Region: PRK05429 509193003218 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 509193003219 nucleotide binding site [chemical binding]; other site 509193003220 homotetrameric interface [polypeptide binding]; other site 509193003221 putative phosphate binding site [ion binding]; other site 509193003222 putative allosteric binding site; other site 509193003223 PUA domain; Region: PUA; cl00607 509193003224 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 509193003225 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 509193003226 putative catalytic cysteine [active] 509193003227 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 509193003228 trimer interface [polypeptide binding]; other site 509193003229 active site 509193003230 dimer interface [polypeptide binding]; other site 509193003231 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 509193003232 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 509193003233 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 509193003234 active site 509193003235 elongation factor P; Validated; Region: PRK00529 509193003236 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 509193003237 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 509193003238 RNA binding site [nucleotide binding]; other site 509193003239 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 509193003240 RNA binding site [nucleotide binding]; other site 509193003241 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 509193003242 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193003243 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 509193003244 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 509193003245 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 509193003246 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 509193003247 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl09803 509193003248 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 509193003249 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 509193003250 Protein of unknown function (DUF322); Region: DUF322; cl00574 509193003251 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 509193003252 putative RNA binding site [nucleotide binding]; other site 509193003253 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14178 509193003254 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 509193003255 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 509193003256 homodimer interface [polypeptide binding]; other site 509193003257 NADP binding site [chemical binding]; other site 509193003258 substrate binding site [chemical binding]; other site 509193003259 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 509193003260 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 509193003261 generic binding surface II; other site 509193003262 generic binding surface I; other site 509193003263 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 509193003264 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 509193003265 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 509193003266 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 509193003267 substrate binding pocket [chemical binding]; other site 509193003268 chain length determination region; other site 509193003269 substrate-Mg2+ binding site; other site 509193003270 catalytic residues [active] 509193003271 aspartate-rich region 1; other site 509193003272 active site lid residues [active] 509193003273 aspartate-rich region 2; other site 509193003274 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 509193003275 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 509193003276 TPP-binding site; other site 509193003277 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 509193003278 PYR/PP interface [polypeptide binding]; other site 509193003279 dimer interface [polypeptide binding]; other site 509193003280 TPP binding site [chemical binding]; other site 509193003281 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509193003282 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 509193003283 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509193003284 RNA binding surface [nucleotide binding]; other site 509193003285 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193003286 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 509193003287 ATP-NAD kinase; Region: NAD_kinase; pfam01513 509193003288 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 509193003289 arginine repressor; Provisional; Region: argR; PRK00441 509193003290 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 509193003291 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 509193003292 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 509193003293 Walker A/P-loop; other site 509193003294 ATP binding site [chemical binding]; other site 509193003295 Q-loop/lid; other site 509193003296 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 509193003297 ABC transporter signature motif; other site 509193003298 Walker B; other site 509193003299 D-loop; other site 509193003300 H-loop/switch region; other site 509193003301 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 509193003302 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 509193003303 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 509193003304 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 509193003305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193003306 active site 509193003307 phosphorylation site [posttranslational modification] 509193003308 intermolecular recognition site; other site 509193003309 dimerization interface [polypeptide binding]; other site 509193003310 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 509193003311 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 509193003312 Thiamine pyrophosphokinase; Region: TPK; cl09135 509193003313 active site 509193003314 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 509193003315 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 509193003316 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 509193003317 Ligand binding site [chemical binding]; other site 509193003318 Putative Catalytic site [active] 509193003319 DXD motif; other site 509193003320 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 509193003321 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 509193003322 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as...; Region: ADPRase_NUDT5; cd03424 509193003323 dimer interface [polypeptide binding]; other site 509193003324 ADP-ribose binding site [chemical binding]; other site 509193003325 active site 509193003326 nudix motif; other site 509193003327 metal binding site [ion binding]; metal-binding site 509193003328 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 509193003329 Integral membrane protein DUF95; Region: DUF95; cl00572 509193003330 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509193003331 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 509193003332 DNA binding site [nucleotide binding] 509193003333 active site 509193003334 Int/Topo IB signature motif; other site 509193003335 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 509193003336 Beta-lactamase; Region: Beta-lactamase; cl01009 509193003337 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 509193003338 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 509193003339 anti sigma factor interaction site; other site 509193003340 regulatory phosphorylation site [posttranslational modification]; other site 509193003341 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193003342 ATP binding site [chemical binding]; other site 509193003343 Mg2+ binding site [ion binding]; other site 509193003344 G-X-G motif; other site 509193003345 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 509193003346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193003347 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 509193003348 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 509193003349 DNA binding residues [nucleotide binding] 509193003350 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 509193003351 SpoVA protein; Region: SpoVA; cl04298 509193003352 stage V sporulation protein AD; Validated; Region: PRK08304 509193003353 SpoVA protein; Region: SpoVA; cl04298 509193003354 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 509193003355 active site 509193003356 NTP binding site [chemical binding]; other site 509193003357 metal binding triad [ion binding]; metal-binding site 509193003358 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 509193003359 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 509193003360 active site 509193003361 putative substrate binding region [chemical binding]; other site 509193003362 ScpA/B protein; Region: ScpA_ScpB; cl00598 509193003363 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 509193003364 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 509193003365 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 509193003366 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 509193003367 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 509193003368 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 509193003369 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 509193003370 dimer interface [polypeptide binding]; other site 509193003371 active site residues [active] 509193003372 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4864 509193003373 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 509193003374 Beta-lactamase; Region: Beta-lactamase; cl01009 509193003375 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 509193003376 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 509193003377 hypothetical protein; Provisional; Region: PRK05802 509193003378 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like; cd06192 509193003379 FAD binding pocket [chemical binding]; other site 509193003380 FAD binding motif [chemical binding]; other site 509193003381 phosphate binding motif [ion binding]; other site 509193003382 beta-alpha-beta structure motif; other site 509193003383 NAD binding pocket [chemical binding]; other site 509193003384 Iron coordination center [ion binding]; other site 509193003385 Glucose inhibited division protein A; Region: GIDA; pfam01134 509193003386 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193003387 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; cl01939 509193003388 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 509193003389 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509193003390 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509193003391 RNA binding surface [nucleotide binding]; other site 509193003392 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 509193003393 active site 509193003394 spermidine synthase; Provisional; Region: PRK00811 509193003395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193003396 S-adenosylmethionine binding site [chemical binding]; other site 509193003397 Arginase family; Region: Arginase; cl00306 509193003398 oxaloacetate decarboxylase; Provisional; Region: PRK12331 509193003399 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 509193003400 active site 509193003401 catalytic residues [active] 509193003402 metal binding site [ion binding]; metal-binding site 509193003403 homodimer binding site [polypeptide binding]; other site 509193003404 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 509193003405 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193003406 putative peptidoglycan binding site; other site 509193003407 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193003408 putative peptidoglycan binding site; other site 509193003409 Survival protein SurE; Region: SurE; cl00448 509193003410 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 509193003411 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 509193003412 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 509193003413 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 509193003414 dimer interface [polypeptide binding]; other site 509193003415 PYR/PP interface [polypeptide binding]; other site 509193003416 TPP binding site [chemical binding]; other site 509193003417 substrate binding site [chemical binding]; other site 509193003418 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 509193003419 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 509193003420 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 509193003421 TPP-binding site [chemical binding]; other site 509193003422 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 509193003423 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 509193003424 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 509193003425 putative active site [active] 509193003426 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 509193003427 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 509193003428 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 509193003429 NAD(P) binding site [chemical binding]; other site 509193003430 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 509193003431 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 509193003432 transmembrane helices; other site 509193003433 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 509193003434 LamB/YcsF family; Region: LamB_YcsF; cl00664 509193003435 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 509193003436 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 509193003437 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 509193003438 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 509193003439 Protein of unknown function (DUF1445); Region: DUF1445; cl01790 509193003440 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 509193003441 catalytic core [active] 509193003442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193003443 flavoprotein, HI0933 family; Region: TIGR00275 509193003444 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In...; Region: AroH; cd02185 509193003445 homotrimer interaction site [polypeptide binding]; other site 509193003446 active site 509193003447 cytidylate kinase; Provisional; Region: cmk; PRK00023 509193003448 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 509193003449 CMP-binding site; other site 509193003450 The sites determining sugar specificity; other site 509193003451 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 509193003452 putative acyl-acceptor binding pocket; other site 509193003453 LytB protein; Region: LYTB; cl00507 509193003454 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 509193003455 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 509193003456 RNA binding site [nucleotide binding]; other site 509193003457 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 509193003458 RNA binding site [nucleotide binding]; other site 509193003459 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 509193003460 RNA binding site [nucleotide binding]; other site 509193003461 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 509193003462 RNA binding site [nucleotide binding]; other site 509193003463 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 509193003464 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 509193003465 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 509193003466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193003467 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 509193003468 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509193003469 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 509193003470 TRAM domain; Region: TRAM; cl01282 509193003471 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 509193003472 MutS domain I; Region: MutS_I; pfam01624 509193003473 MutS domain II; Region: MutS_II; pfam05188 509193003474 MutS family domain IV; Region: MutS_IV; pfam05190 509193003475 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 509193003476 Walker A/P-loop; other site 509193003477 ATP binding site [chemical binding]; other site 509193003478 Q-loop/lid; other site 509193003479 ABC transporter signature motif; other site 509193003480 Walker B; other site 509193003481 D-loop; other site 509193003482 H-loop/switch region; other site 509193003483 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 509193003484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 509193003485 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 509193003486 ATP binding site [chemical binding]; other site 509193003487 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 509193003488 IPP transferase; Region: IPPT; cl00403 509193003489 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 509193003490 Sm1 motif; other site 509193003491 intra - hexamer interaction site; other site 509193003492 inter - hexamer interaction site [polypeptide binding]; other site 509193003493 nucleotide binding pocket [chemical binding]; other site 509193003494 Sm2 motif; other site 509193003495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193003496 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 509193003497 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 509193003498 RNA/DNA hybrid binding site [nucleotide binding]; other site 509193003499 active site 509193003500 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 509193003501 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 509193003502 DNA binding site [nucleotide binding] 509193003503 Int/Topo IB signature motif; other site 509193003504 active site 509193003505 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 509193003506 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 509193003507 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509193003508 catalytic residue [active] 509193003509 stage V sporulation protein K; Region: spore_V_K; TIGR02881 509193003510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193003511 Walker A motif; other site 509193003512 ATP binding site [chemical binding]; other site 509193003513 Walker B motif; other site 509193003514 arginine finger; other site 509193003515 adenylosuccinate lyase; Region: purB; TIGR00928 509193003516 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 509193003517 tetramer interface [polypeptide binding]; other site 509193003518 active site 509193003519 aspartate aminotransferase; Provisional; Region: PRK08361 509193003520 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509193003521 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193003522 homodimer interface [polypeptide binding]; other site 509193003523 catalytic residue [active] 509193003524 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 509193003525 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 509193003526 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 509193003527 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509193003528 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 509193003529 putative active site [active] 509193003530 metal binding site [ion binding]; metal-binding site 509193003531 homodimer binding site [polypeptide binding]; other site 509193003532 phosphodiesterase; Provisional; Region: PRK12704 509193003533 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509193003534 Transposase domain (DUF772); Region: DUF772; cl12084 509193003535 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 509193003536 RecX family; Region: RecX; cl00936 509193003537 recombinase A; Provisional; Region: recA; PRK09354 509193003538 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 509193003539 hexamer interface [polypeptide binding]; other site 509193003540 Walker A motif; other site 509193003541 ATP binding site [chemical binding]; other site 509193003542 Walker B motif; other site 509193003543 competence damage-inducible protein A; Provisional; Region: PRK00549 509193003544 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 509193003545 putative MPT binding site; other site 509193003546 Competence-damaged protein; Region: CinA; cl00666 509193003547 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 509193003548 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509193003549 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 509193003550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193003551 FeS/SAM binding site; other site 509193003552 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193003553 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 509193003554 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 509193003555 active site 509193003556 aspartate kinase I; Reviewed; Region: PRK08210 509193003557 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 509193003558 nucleotide binding site [chemical binding]; other site 509193003559 substrate binding site [chemical binding]; other site 509193003560 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 509193003561 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 509193003562 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 509193003563 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 509193003564 trimer interface [polypeptide binding]; other site 509193003565 active site 509193003566 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 509193003567 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 509193003568 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 509193003569 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 509193003570 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 509193003571 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 509193003572 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 509193003573 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 509193003574 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 509193003575 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 509193003576 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 509193003577 putative nucleic acid binding region [nucleotide binding]; other site 509193003578 G-X-X-G motif; other site 509193003579 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 509193003580 RNA binding site [nucleotide binding]; other site 509193003581 domain interface; other site 509193003582 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 509193003583 16S/18S rRNA binding site [nucleotide binding]; other site 509193003584 S13e-L30e interaction site [polypeptide binding]; other site 509193003585 25S rRNA binding site [nucleotide binding]; other site 509193003586 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 509193003587 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 509193003588 active site 509193003589 Riboflavin kinase; Region: Flavokinase; pfam01687 509193003590 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 509193003591 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 509193003592 RNA binding site [nucleotide binding]; other site 509193003593 active site 509193003594 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 509193003595 DHH family; Region: DHH; pfam01368 509193003596 DHHA1 domain; Region: DHHA1; pfam02272 509193003597 Ribosome-binding factor A; Region: RBFA; cl00542 509193003598 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 509193003599 translation initiation factor IF-2; Region: IF-2; TIGR00487 509193003600 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 509193003601 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 509193003602 G1 box; other site 509193003603 putative GEF interaction site [polypeptide binding]; other site 509193003604 GTP/Mg2+ binding site [chemical binding]; other site 509193003605 Switch I region; other site 509193003606 G2 box; other site 509193003607 G3 box; other site 509193003608 Switch II region; other site 509193003609 G4 box; other site 509193003610 G5 box; other site 509193003611 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 509193003612 Translation-initiation factor 2; Region: IF-2; pfam11987 509193003613 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 509193003614 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 509193003615 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 509193003616 putative RNA binding cleft [nucleotide binding]; other site 509193003617 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 509193003618 NusA N-terminal domain; Region: NusA_N; pfam08529 509193003619 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 509193003620 RNA binding site [nucleotide binding]; other site 509193003621 homodimer interface [polypeptide binding]; other site 509193003622 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 509193003623 G-X-X-G motif; other site 509193003624 ribosome maturation protein RimP; Reviewed; Region: PRK00092 509193003625 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members...; Region: Sm_like; cl00259 509193003626 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 509193003627 Sm1 motif; other site 509193003628 predicted subunit interaction site [polypeptide binding]; other site 509193003629 RNA binding pocket [nucleotide binding]; other site 509193003630 Sm2 motif; other site 509193003631 DNA polymerase III PolC; Validated; Region: polC; PRK00448 509193003632 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 509193003633 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 509193003634 generic binding surface II; other site 509193003635 generic binding surface I; other site 509193003636 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 509193003637 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 509193003638 active site 509193003639 substrate binding site [chemical binding]; other site 509193003640 catalytic site [active] 509193003641 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 509193003642 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 509193003643 Ligand binding site [chemical binding]; other site 509193003644 Putative Catalytic site [active] 509193003645 DXD motif; other site 509193003646 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 509193003647 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 509193003648 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 509193003649 active site 509193003650 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 509193003651 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 509193003652 putative substrate binding region [chemical binding]; other site 509193003653 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 509193003654 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 509193003655 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 509193003656 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 509193003657 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 509193003658 catalytic residue [active] 509193003659 putative FPP diphosphate binding site; other site 509193003660 putative FPP binding hydrophobic cleft; other site 509193003661 dimer interface [polypeptide binding]; other site 509193003662 putative IPP diphosphate binding site; other site 509193003663 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 509193003664 hinge region; other site 509193003665 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 509193003666 putative nucleotide binding site [chemical binding]; other site 509193003667 uridine monophosphate binding site [chemical binding]; other site 509193003668 homohexameric interface [polypeptide binding]; other site 509193003669 elongation factor Ts; Reviewed; Region: tsf; PRK12332 509193003670 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 509193003671 Elongation factor TS; Region: EF_TS; pfam00889 509193003672 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 509193003673 rRNA interaction site [nucleotide binding]; other site 509193003674 S8 interaction site; other site 509193003675 putative laminin-1 binding site; other site 509193003676 Protein of unknown function (DUF342); Region: DUF342; pfam03961 509193003677 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 509193003678 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 509193003679 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 509193003680 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 509193003681 DNA binding residues [nucleotide binding] 509193003682 CheD chemotactic sensory transduction; Region: CheD; cl00810 509193003683 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 509193003684 CheC-like family; Region: CheC; pfam04509 509193003685 CheC-like family; Region: CheC; pfam04509 509193003686 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 509193003687 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 509193003688 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 509193003689 putative binding surface; other site 509193003690 active site 509193003691 P2 response regulator binding domain; Region: P2; pfam07194 509193003692 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 509193003693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193003694 ATP binding site [chemical binding]; other site 509193003695 Mg2+ binding site [ion binding]; other site 509193003696 G-X-G motif; other site 509193003697 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 509193003698 CheB methylesterase; Region: CheB_methylest; pfam01339 509193003699 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 509193003700 Flagellar protein YcgR; Region: YcgR_2; pfam12945 509193003701 PilZ domain; Region: PilZ; cl01260 509193003702 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 509193003703 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 509193003704 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 509193003705 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 509193003706 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 509193003707 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 509193003708 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 509193003709 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 509193003710 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 509193003711 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 509193003712 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 509193003713 FliP family; Region: FliP; cl00593 509193003714 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 509193003715 Response regulator receiver domain; Region: Response_reg; pfam00072 509193003716 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193003717 active site 509193003718 phosphorylation site [posttranslational modification] 509193003719 intermolecular recognition site; other site 509193003720 dimerization interface [polypeptide binding]; other site 509193003721 flagellar motor switch protein; Validated; Region: PRK08119 509193003722 CheC-like family; Region: CheC; pfam04509 509193003723 CheC-like family; Region: CheC; pfam04509 509193003724 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 509193003725 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 509193003726 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 509193003727 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 509193003728 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 509193003729 Flagellar protein (FlbD); Region: FlbD; cl00683 509193003730 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 509193003731 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 509193003732 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 509193003733 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 509193003734 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 509193003735 Flagellar hook capping protein; Region: FlgD; cl04347 509193003736 Flagellar hook-length control protein FliK; Region: Flg_hook; cl14669 509193003737 MgtE intracellular N domain; Region: MgtE_N; cl15244 509193003738 Flagellar FliJ protein; Region: FliJ; cl09161 509193003739 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 509193003740 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 509193003741 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509193003742 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 509193003743 Walker A motif/ATP binding site; other site 509193003744 Walker B motif; other site 509193003745 Flagellar biosynthesis/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliH; COG1317 509193003746 Flagellar assembly protein FliH; Region: FliH; pfam02108 509193003747 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 509193003748 FliG C-terminal domain; Region: FliG_C; pfam01706 509193003749 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 509193003750 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 509193003751 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 509193003752 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 509193003753 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 509193003754 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 509193003755 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 509193003756 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 509193003757 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 509193003758 transcriptional repressor CodY; Validated; Region: PRK04158 509193003759 CodY GAF-like domain; Region: CodY; pfam06018 509193003760 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 509193003761 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 509193003762 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193003763 Walker A motif; other site 509193003764 ATP binding site [chemical binding]; other site 509193003765 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193003766 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 509193003767 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 509193003768 active site 509193003769 HslU subunit interaction site [polypeptide binding]; other site 509193003770 DNA topoisomerase I; Validated; Region: PRK05582 509193003771 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 509193003772 active site 509193003773 interdomain interaction site; other site 509193003774 putative metal-binding site [ion binding]; other site 509193003775 nucleotide binding site [chemical binding]; other site 509193003776 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 509193003777 domain I; other site 509193003778 DNA binding groove [nucleotide binding] 509193003779 phosphate binding site [ion binding]; other site 509193003780 domain II; other site 509193003781 domain III; other site 509193003782 nucleotide binding site [chemical binding]; other site 509193003783 catalytic site [active] 509193003784 domain IV; other site 509193003785 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 509193003786 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 509193003787 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 509193003788 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 509193003789 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193003790 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 509193003791 RNA/DNA hybrid binding site [nucleotide binding]; other site 509193003792 active site 509193003793 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 509193003794 tryptophanyl-tRNA synthetase; Region: trpS; TIGR00233 509193003795 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 509193003796 active site 509193003797 HIGH motif; other site 509193003798 dimer interface [polypeptide binding]; other site 509193003799 KMSKS motif; other site 509193003800 Uncharacterized conserved protein [Function unknown]; Region: COG1284 509193003801 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 509193003802 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 509193003803 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 509193003804 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 509193003805 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193003806 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 509193003807 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases...; Region: YlqF; cd01856 509193003808 GTP/Mg2+ binding site [chemical binding]; other site 509193003809 G4 box; other site 509193003810 G5 box; other site 509193003811 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 509193003812 G1 box; other site 509193003813 G1 box; other site 509193003814 GTP/Mg2+ binding site [chemical binding]; other site 509193003815 Switch I region; other site 509193003816 G2 box; other site 509193003817 G2 box; other site 509193003818 Switch I region; other site 509193003819 G3 box; other site 509193003820 G3 box; other site 509193003821 Switch II region; other site 509193003822 Switch II region; other site 509193003823 G4 box; other site 509193003824 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 509193003825 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 509193003826 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 509193003827 RimM N-terminal domain; Region: RimM; pfam01782 509193003828 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 509193003829 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 509193003830 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 509193003831 signal recognition particle protein; Provisional; Region: PRK10867 509193003832 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 509193003833 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509193003834 P loop; other site 509193003835 GTP binding site [chemical binding]; other site 509193003836 Signal peptide binding domain; Region: SRP_SPB; pfam02978 509193003837 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 509193003838 DNA binding residues [nucleotide binding] 509193003839 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 509193003840 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 509193003841 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 509193003842 P loop; other site 509193003843 GTP binding site [chemical binding]; other site 509193003844 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 509193003845 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 509193003846 Walker A/P-loop; other site 509193003847 ATP binding site [chemical binding]; other site 509193003848 Q-loop/lid; other site 509193003849 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 509193003850 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 509193003851 ABC transporter signature motif; other site 509193003852 Walker B; other site 509193003853 D-loop; other site 509193003854 H-loop/switch region; other site 509193003855 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 509193003856 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193003857 Radical SAM; Region: Elp3; smart00729 509193003858 FeS/SAM binding site; other site 509193003859 ribonuclease III; Reviewed; Region: rnc; PRK00102 509193003860 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 509193003861 dimerization interface [polypeptide binding]; other site 509193003862 active site 509193003863 metal binding site [ion binding]; metal-binding site 509193003864 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 509193003865 dsRNA binding site [nucleotide binding]; other site 509193003866 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 509193003867 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 509193003868 dimer interface [polypeptide binding]; other site 509193003869 active site 509193003870 Phosphopantetheine attachment site; Region: PP-binding; cl09936 509193003871 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 509193003872 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 509193003873 NAD(P) binding site [chemical binding]; other site 509193003874 homotetramer interface [polypeptide binding]; other site 509193003875 homodimer interface [polypeptide binding]; other site 509193003876 active site 509193003877 Acyl transferase domain; Region: Acyl_transf_1; cl08282 509193003878 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 509193003879 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 509193003880 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 509193003881 FMN binding site [chemical binding]; other site 509193003882 substrate binding site [chemical binding]; other site 509193003883 putative catalytic residue [active] 509193003884 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 509193003885 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 509193003886 dimer interface [polypeptide binding]; other site 509193003887 active site 509193003888 CoA binding pocket [chemical binding]; other site 509193003889 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 509193003890 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 509193003891 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 509193003892 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 509193003893 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 509193003894 Acetokinase family; Region: Acetate_kinase; cl01029 509193003895 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 509193003896 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 509193003897 hypothetical protein; Provisional; Region: PRK13670 509193003898 hypothetical protein; Provisional; Region: PRK13671 509193003899 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 509193003900 Nucleoside recognition; Region: Gate; cl00486 509193003901 Nucleoside recognition; Region: Gate; cl00486 509193003902 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 509193003903 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 509193003904 active site 509193003905 (T/H)XGH motif; other site 509193003906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193003907 S-adenosylmethionine binding site [chemical binding]; other site 509193003908 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 509193003909 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 509193003910 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 509193003911 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 509193003912 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 509193003913 generic binding surface II; other site 509193003914 ssDNA binding site; other site 509193003915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509193003916 ATP binding site [chemical binding]; other site 509193003917 putative Mg++ binding site [ion binding]; other site 509193003918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509193003919 nucleotide binding region [chemical binding]; other site 509193003920 ATP-binding site [chemical binding]; other site 509193003921 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 509193003922 DAK2 domain; Region: Dak2; cl03685 509193003923 Protein of unknown function (DUF322); Region: DUF322; cl00574 509193003924 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 509193003925 Thiamine pyrophosphokinase; Region: TPK; cd07995 509193003926 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 509193003927 active site 509193003928 dimerization interface [polypeptide binding]; other site 509193003929 thiamine binding site [chemical binding]; other site 509193003930 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 509193003931 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 509193003932 substrate binding site [chemical binding]; other site 509193003933 hexamer interface [polypeptide binding]; other site 509193003934 metal binding site [ion binding]; metal-binding site 509193003935 GTPase RsgA; Reviewed; Region: PRK00098 509193003936 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence...; Region: YjeQ_engC; cd01854 509193003937 GTPase/OB domain interface [polypeptide binding]; other site 509193003938 GTPase/Zn-binding domain interface [polypeptide binding]; other site 509193003939 GTP/Mg2+ binding site [chemical binding]; other site 509193003940 G4 box; other site 509193003941 G5 box; other site 509193003942 G1 box; other site 509193003943 Switch I region; other site 509193003944 G2 box; other site 509193003945 G3 box; other site 509193003946 Switch II region; other site 509193003947 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 509193003948 active site 509193003949 ATP binding site [chemical binding]; other site 509193003950 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 509193003951 substrate binding site [chemical binding]; other site 509193003952 activation loop (A-loop); other site 509193003953 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 509193003954 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 509193003955 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis...; Region: PASTA_pknB; cd06577 509193003956 Protein phosphatase 2C; Region: PP2C; pfam00481 509193003957 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 509193003958 Active site [active] 509193003959 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 509193003960 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193003961 FeS/SAM binding site; other site 509193003962 16S rRNA methyltransferase B; Provisional; Region: PRK14902 509193003963 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 509193003964 putative RNA binding site [nucleotide binding]; other site 509193003965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193003966 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 509193003967 Protein of unknown function DUF116; Region: DUF116; cl00800 509193003968 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 509193003969 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 509193003970 putative active site [active] 509193003971 substrate binding site [chemical binding]; other site 509193003972 putative cosubstrate binding site; other site 509193003973 catalytic site [active] 509193003974 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 509193003975 substrate binding site [chemical binding]; other site 509193003976 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 509193003977 active site 509193003978 catalytic residues [active] 509193003979 metal binding site [ion binding]; metal-binding site 509193003980 primosome assembly protein PriA; Validated; Region: PRK05580 509193003981 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 509193003982 ATP binding site [chemical binding]; other site 509193003983 putative Mg++ binding site [ion binding]; other site 509193003984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509193003985 ATP-binding site [chemical binding]; other site 509193003986 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 509193003987 Flavoprotein; Region: Flavoprotein; cl08021 509193003988 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 509193003989 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 509193003990 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 509193003991 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 509193003992 catalytic site [active] 509193003993 G-X2-G-X-G-K; other site 509193003994 Domain of unknown function (DUF370); Region: DUF370; cl00898 509193003995 hypothetical protein; Provisional; Region: PRK11820 509193003996 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 509193003997 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 509193003998 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 509193003999 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 509193004000 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 509193004001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193004002 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509193004003 putative substrate translocation pore; other site 509193004004 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 509193004005 Domain of unknown function (DUF814); Region: DUF814; pfam05670 509193004006 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 509193004007 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 509193004008 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 509193004009 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein; Region: ABC_MetN_methionine_transporter; cd03258 509193004010 Walker A/P-loop; other site 509193004011 ATP binding site [chemical binding]; other site 509193004012 Q-loop/lid; other site 509193004013 ABC transporter signature motif; other site 509193004014 Walker B; other site 509193004015 D-loop; other site 509193004016 H-loop/switch region; other site 509193004017 NIL domain; Region: NIL; pfam09383 509193004018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193004019 dimer interface [polypeptide binding]; other site 509193004020 conserved gate region; other site 509193004021 ABC-ATPase subunit interface; other site 509193004022 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193004023 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 509193004024 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 509193004025 Ligand Binding Site [chemical binding]; other site 509193004026 PUA domain; Region: PUA; cl00607 509193004027 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 509193004028 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193004029 S-adenosylmethionine binding site [chemical binding]; other site 509193004030 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193004031 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193004032 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 509193004033 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 509193004034 heterodimer interface [polypeptide binding]; other site 509193004035 active site 509193004036 FMN binding site [chemical binding]; other site 509193004037 homodimer interface [polypeptide binding]; other site 509193004038 substrate binding site [chemical binding]; other site 509193004039 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 509193004040 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 509193004041 FAD binding pocket [chemical binding]; other site 509193004042 FAD binding motif [chemical binding]; other site 509193004043 phosphate binding motif [ion binding]; other site 509193004044 beta-alpha-beta structure motif; other site 509193004045 NAD binding pocket [chemical binding]; other site 509193004046 Iron coordination center [ion binding]; other site 509193004047 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 509193004048 active site 509193004049 dimer interface [polypeptide binding]; other site 509193004050 dihydroorotase; Validated; Region: pyrC; PRK09357 509193004051 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 509193004052 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 509193004053 active site 509193004054 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 509193004055 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 509193004056 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 509193004057 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193004058 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 509193004059 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 509193004060 dimerization interface [polypeptide binding]; other site 509193004061 putative ATP binding site [chemical binding]; other site 509193004062 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 509193004063 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509193004064 RNA binding surface [nucleotide binding]; other site 509193004065 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 509193004066 active site 509193004067 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 509193004068 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 509193004069 binding surface 509193004070 TPR motif; other site 509193004071 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 509193004072 binding surface 509193004073 TPR motif; other site 509193004074 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 509193004075 Protein of unknown function (DUF524); Region: DUF524; pfam04411 509193004076 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509193004077 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 509193004078 SmpB-tmRNA interface; other site 509193004079 ribonuclease R; Region: RNase_R; TIGR02063 509193004080 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 509193004081 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 509193004082 RNB domain; Region: RNB; pfam00773 509193004083 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 509193004084 RNA binding site [nucleotide binding]; other site 509193004085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509193004086 pyruvate phosphate dikinase; Provisional; Region: PRK09279 509193004087 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 509193004088 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 509193004089 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 509193004090 Domain of unknown function (DUF299); Region: DUF299; cl00780 509193004091 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193004092 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair_4; cd04617 509193004093 FOG: CBS domain [General function prediction only]; Region: COG0517 509193004094 glycyl-tRNA synthetase; Provisional; Region: PRK04173 509193004095 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 509193004096 motif 1; other site 509193004097 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the...; Region: GlyRS-like_core; cd00774 509193004098 active site 509193004099 motif 2; other site 509193004100 motif 3; other site 509193004101 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 509193004102 anticodon binding site; other site 509193004103 Recombination protein O N terminal; Region: RecO_N; pfam11967 509193004104 DNA repair protein RecO; Region: reco; TIGR00613 509193004105 Recombination protein O C terminal; Region: RecO_C; pfam02565 509193004106 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 509193004107 intersubunit interface [polypeptide binding]; other site 509193004108 active site 509193004109 catalytic residue [active] 509193004110 GTPase Era; Reviewed; Region: era; PRK00089 509193004111 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 509193004112 G1 box; other site 509193004113 GTP/Mg2+ binding site [chemical binding]; other site 509193004114 Switch I region; other site 509193004115 G2 box; other site 509193004116 Switch II region; other site 509193004117 G3 box; other site 509193004118 G4 box; other site 509193004119 G5 box; other site 509193004120 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 509193004121 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 509193004122 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 509193004123 active site 509193004124 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 509193004125 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 509193004126 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 509193004127 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193004128 Zn2+ binding site [ion binding]; other site 509193004129 Mg2+ binding site [ion binding]; other site 509193004130 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 509193004131 PhoH-like protein; Region: PhoH; cl12134 509193004132 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 509193004133 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 509193004134 YabP family; Region: YabP; cl06766 509193004135 Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspartic acid and ammonia. In bacteria, there are two classes of amidohydrolases, one highly specific for asparagine and localised to the...; Region: Asparaginase; cl00216 509193004136 active site/substrate binding site [active] 509193004137 tetramer interface [polypeptide binding]; other site 509193004138 GatB domain; Region: GatB_Yqey; cl11497 509193004139 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 509193004140 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 509193004141 nucleotide binding site/active site [active] 509193004142 HIT family signature motif; other site 509193004143 catalytic residue [active] 509193004144 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 509193004145 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 509193004146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193004147 FeS/SAM binding site; other site 509193004148 TRAM domain; Region: TRAM; cl01282 509193004149 PAS fold; Region: PAS_4; pfam08448 509193004150 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509193004151 putative active site [active] 509193004152 heme pocket [chemical binding]; other site 509193004153 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 509193004154 metal binding site [ion binding]; metal-binding site 509193004155 active site 509193004156 I-site; other site 509193004157 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 509193004158 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509193004159 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 509193004160 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193004161 Zn2+ binding site [ion binding]; other site 509193004162 Mg2+ binding site [ion binding]; other site 509193004163 B12-binding domain/radical SAM domain protein, MJ_1487 family; Region: B12_SAM_MJ_1487; TIGR04013 509193004164 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193004165 FeS/SAM binding site; other site 509193004166 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509193004167 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193004168 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193004169 Walker A/P-loop; other site 509193004170 ATP binding site [chemical binding]; other site 509193004171 Q-loop/lid; other site 509193004172 ABC transporter signature motif; other site 509193004173 Walker B; other site 509193004174 D-loop; other site 509193004175 H-loop/switch region; other site 509193004176 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 509193004177 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 509193004178 ABC transporter; Region: ABC_tran_2; pfam12848 509193004179 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 509193004180 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by...; Region: ABCF_EF-3; cd03221 509193004181 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193004182 Integrase core domain; Region: rve; cl01316 509193004183 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 509193004184 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 509193004185 Transposase; Region: DDE_Tnp_ISL3; pfam01610 509193004186 Transposase domain (DUF772); Region: DUF772; cl12084 509193004187 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 509193004188 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 509193004189 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193004190 S-adenosylmethionine binding site [chemical binding]; other site 509193004191 chaperone protein DnaJ; Provisional; Region: PRK14277 509193004192 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 509193004193 HSP70 interaction site [polypeptide binding]; other site 509193004194 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 509193004195 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 509193004196 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 509193004197 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 509193004198 dimer interface [polypeptide binding]; other site 509193004199 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 509193004200 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 509193004201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193004202 HrcA protein C terminal domain; Region: HrcA; pfam01628 509193004203 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 509193004204 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193004205 FeS/SAM binding site; other site 509193004206 HemN C-terminal region; Region: HemN_C; pfam06969 509193004207 GTP-binding protein LepA; Provisional; Region: PRK05433 509193004208 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 509193004209 G1 box; other site 509193004210 putative GEF interaction site [polypeptide binding]; other site 509193004211 GTP/Mg2+ binding site [chemical binding]; other site 509193004212 Switch I region; other site 509193004213 G2 box; other site 509193004214 G3 box; other site 509193004215 Switch II region; other site 509193004216 G4 box; other site 509193004217 G5 box; other site 509193004218 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 509193004219 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 509193004220 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 509193004221 Sulfatase; Region: Sulfatase; cl10460 509193004222 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 509193004223 stage II sporulation protein P; Region: spore_II_P; TIGR02867 509193004224 Germination protease; Region: Peptidase_A25; cl04057 509193004225 Membrane protein of unknown function; Region: DUF360; cl00850 509193004226 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 509193004227 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 509193004228 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 509193004229 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 509193004230 Competence protein; Region: Competence; cl00471 509193004231 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193004232 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 509193004233 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193004234 active site 509193004235 motif I; other site 509193004236 motif II; other site 509193004237 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 509193004238 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 509193004239 branched-chain amino acid aminotransferase; Provisional; Region: PRK12479 509193004240 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and D-...; Region: D-AAT_like; cd01558 509193004241 homodimer interface [polypeptide binding]; other site 509193004242 substrate-cofactor binding pocket; other site 509193004243 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193004244 catalytic residue [active] 509193004245 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 509193004246 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 509193004247 Integrase core domain; Region: rve; cl01316 509193004248 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 509193004249 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193004250 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 509193004251 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509193004252 active site 509193004253 HIGH motif; other site 509193004254 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 509193004255 active site 509193004256 KMSKS motif; other site 509193004257 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 509193004258 tetramer interfaces [polypeptide binding]; other site 509193004259 binuclear metal-binding site [ion binding]; other site 509193004260 SLBB domain; Region: SLBB; pfam10531 509193004261 comEA protein; Region: comE; TIGR01259 509193004262 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 509193004263 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 509193004264 Beta-lactamase; Region: Beta-lactamase; cl01009 509193004265 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 509193004266 asparagine synthetase B; Provisional; Region: asnB; PRK09431 509193004267 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 509193004268 active site 509193004269 dimer interface [polypeptide binding]; other site 509193004270 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 509193004271 Ligand Binding Site [chemical binding]; other site 509193004272 Molecular Tunnel; other site 509193004273 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 509193004274 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to L-threo-; Region: Glm_e; cl02025 509193004275 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193004276 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 509193004277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 509193004278 YheO-like PAS domain; Region: PAS_6; pfam08348 509193004279 Domain of unknown function DUF143; Region: DUF143; cl00519 509193004280 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 509193004281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509193004282 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 509193004283 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 509193004284 active site 509193004285 (T/H)XGH motif; other site 509193004286 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193004287 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193004288 putative active site [active] 509193004289 putative NTP binding site [chemical binding]; other site 509193004290 putative nucleic acid binding site [nucleotide binding]; other site 509193004291 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193004292 GTPase CgtA; Reviewed; Region: obgE; PRK12297 509193004293 GTP1/OBG; Region: GTP1_OBG; pfam01018 509193004294 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 509193004295 G1 box; other site 509193004296 GTP/Mg2+ binding site [chemical binding]; other site 509193004297 Switch I region; other site 509193004298 G2 box; other site 509193004299 G3 box; other site 509193004300 Switch II region; other site 509193004301 G4 box; other site 509193004302 G5 box; other site 509193004303 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 509193004304 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 509193004305 Protein of unknown function (DUF464); Region: DUF464; cl01080 509193004306 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 509193004307 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 509193004308 QueT transporter; Region: QueT; cl01932 509193004309 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 509193004310 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 509193004311 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 509193004312 homodimer interface [polypeptide binding]; other site 509193004313 oligonucleotide binding site [chemical binding]; other site 509193004314 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 509193004315 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 509193004316 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 509193004317 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase...; Region: B12-binding_like; cl00293 509193004318 B12 binding site [chemical binding]; other site 509193004319 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 509193004320 FeS/SAM binding site; other site 509193004321 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 509193004322 active site 509193004323 putative substrate binding region [chemical binding]; other site 509193004324 Peptidase family M23; Region: Peptidase_M23; pfam01551 509193004325 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 509193004326 active site 509193004327 dimer interfaces [polypeptide binding]; other site 509193004328 catalytic residues [active] 509193004329 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 509193004330 Septum formation topological specificity factor MinE; Region: MinE; cl00538 509193004331 septum site-determining protein MinD; Region: minD_bact; TIGR01968 509193004332 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a...; Region: MinD; cd02036 509193004333 Switch I; other site 509193004334 Switch II; other site 509193004335 septum formation inhibitor; Reviewed; Region: minC; PRK00513 509193004336 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 509193004337 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509193004338 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 509193004339 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 509193004340 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 509193004341 rod shape-determining protein MreD; Region: MreD; cl01087 509193004342 Protein of unknown function (DUF904); Region: DUF904; cl11531 509193004343 rod shape-determining protein MreC; Region: MreC; pfam04085 509193004344 rod shape-determining protein MreB; Provisional; Region: PRK13927 509193004345 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 509193004346 ATP binding site [chemical binding]; other site 509193004347 gelsolin binding site; other site 509193004348 profilin binding site; other site 509193004349 hypothetical protein; Reviewed; Region: PRK00024 509193004350 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 509193004351 MPN+ (JAMM) motif; other site 509193004352 Zinc-binding site [ion binding]; other site 509193004353 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 509193004354 active site 509193004355 dimer interface [polypeptide binding]; other site 509193004356 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 509193004357 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 509193004358 catalytic loop [active] 509193004359 iron binding site [ion binding]; other site 509193004360 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 509193004361 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 509193004362 4Fe-4S binding domain; Region: Fer4; cl02805 509193004363 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 509193004364 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 509193004365 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 509193004366 dimer interface [polypeptide binding]; other site 509193004367 [2Fe-2S] cluster binding site [ion binding]; other site 509193004368 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 509193004369 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 509193004370 SLBB domain; Region: SLBB; pfam10531 509193004371 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 509193004372 4Fe-4S binding domain; Region: Fer4; cl02805 509193004373 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 509193004374 4Fe-4S binding domain; Region: Fer4; cl02805 509193004375 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:; Region: TRX_Fd_family; cd02980 509193004376 dimer interface [polypeptide binding]; other site 509193004377 [2Fe-2S] cluster binding site [ion binding]; other site 509193004378 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193004379 ATP binding site [chemical binding]; other site 509193004380 Mg2+ binding site [ion binding]; other site 509193004381 G-X-G motif; other site 509193004382 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of...; Region: TRX_Fd_NuoE; cd03064 509193004383 putative dimer interface [polypeptide binding]; other site 509193004384 [2Fe-2S] cluster binding site [ion binding]; other site 509193004385 PHP domain; Region: PHP; pfam02811 509193004386 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 509193004387 DRTGG domain; Region: DRTGG; cl12147 509193004388 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 509193004389 4Fe-4S binding domain; Region: Fer4; cl02805 509193004390 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 509193004391 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456 509193004392 Putative Fe-S cluster; Region: FeS; pfam04060 509193004393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 509193004394 DRTGG domain; Region: DRTGG; cl12147 509193004395 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509193004396 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509193004397 catalytic residue [active] 509193004398 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 509193004399 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 509193004400 G1 box; other site 509193004401 putative GEF interaction site [polypeptide binding]; other site 509193004402 GTP/Mg2+ binding site [chemical binding]; other site 509193004403 Switch I region; other site 509193004404 G2 box; other site 509193004405 G3 box; other site 509193004406 Switch II region; other site 509193004407 G4 box; other site 509193004408 G5 box; other site 509193004409 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 509193004410 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a...; Region: BipA_TypA_C; cd03710 509193004411 Bacterial SH3 domain; Region: SH3_3; cl02551 509193004412 Bacterial SH3 domain; Region: SH3_3; cl02551 509193004413 Bacterial SH3 domain; Region: SH3_3; cl02551 509193004414 NlpC/P60 family; Region: NLPC_P60; cl11438 509193004415 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 509193004416 peptide binding site [polypeptide binding]; other site 509193004417 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 509193004418 dimer interface [polypeptide binding]; other site 509193004419 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 509193004420 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_B; cd01571 509193004421 active site 509193004422 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509193004423 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509193004424 catalytic residue [active] 509193004425 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 509193004426 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 509193004427 CoA-binding site [chemical binding]; other site 509193004428 ATP-binding [chemical binding]; other site 509193004429 DNA polymerase I; Provisional; Region: PRK05755 509193004430 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 509193004431 active site 509193004432 metal binding site 1 [ion binding]; metal-binding site 509193004433 putative 5' ssDNA interaction site; other site 509193004434 metal binding site 3; metal-binding site 509193004435 metal binding site 2 [ion binding]; metal-binding site 509193004436 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 509193004437 putative DNA binding site [nucleotide binding]; other site 509193004438 putative metal binding site [ion binding]; other site 509193004439 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 509193004440 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 509193004441 active site 509193004442 DNA binding site [nucleotide binding] 509193004443 catalytic site [active] 509193004444 PspC domain; Region: PspC; cl00864 509193004445 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 509193004446 active site 509193004447 Glycosyl hydrolase family 18; Region: Glyco_18; smart00636 509193004448 Protein of unknown function (DUF436); Region: DUF436; cl01860 509193004449 Phd_YefM; Region: PhdYeFM; cl09153 509193004450 Protein of unknown function DUF86; Region: DUF86; cl01031 509193004451 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509193004452 active site 509193004453 NTP binding site [chemical binding]; other site 509193004454 metal binding triad [ion binding]; metal-binding site 509193004455 antibiotic binding site [chemical binding]; other site 509193004456 Putative amidase domain; Region: Amidase_6; pfam12671 509193004457 tyrosine 2,3-aminomutase; Region: Tyr_2_3_mutase; TIGR03832 509193004458 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 509193004459 active sites [active] 509193004460 tetramer interface [polypeptide binding]; other site 509193004461 Uncharacterised protein family (UPF0180); Region: UPF0180; cl04214 509193004462 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 509193004463 Peptidase family M23; Region: Peptidase_M23; pfam01551 509193004464 Polymer-forming cytoskeletal; Region: Bactofilin; cl09137 509193004465 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 509193004466 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509193004467 DNA-binding site [nucleotide binding]; DNA binding site 509193004468 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509193004469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193004470 homodimer interface [polypeptide binding]; other site 509193004471 catalytic residue [active] 509193004472 isoaspartyl dipeptidase; Provisional; Region: PRK10657 509193004473 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with...; Region: Isoaspartyl-dipeptidase; cd01308 509193004474 dimer interface [polypeptide binding]; other site 509193004475 active site 509193004476 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 509193004477 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193004478 active site 509193004479 phosphorylation site [posttranslational modification] 509193004480 intermolecular recognition site; other site 509193004481 dimerization interface [polypeptide binding]; other site 509193004482 ANTAR domain; Region: ANTAR; pfam03861 509193004483 glutamine synthetase, type I; Region: GlnA; TIGR00653 509193004484 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 509193004485 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509193004486 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193004487 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 509193004488 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193004489 Walker A/P-loop; other site 509193004490 ATP binding site [chemical binding]; other site 509193004491 Q-loop/lid; other site 509193004492 ABC transporter signature motif; other site 509193004493 Walker B; other site 509193004494 D-loop; other site 509193004495 H-loop/switch region; other site 509193004496 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 509193004497 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 509193004498 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide...; Region: ABCC_Glucan_exporter_like; cd03254 509193004499 Walker A/P-loop; other site 509193004500 ATP binding site [chemical binding]; other site 509193004501 Q-loop/lid; other site 509193004502 ABC transporter signature motif; other site 509193004503 Walker B; other site 509193004504 D-loop; other site 509193004505 H-loop/switch region; other site 509193004506 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 509193004507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193004508 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 509193004509 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 509193004510 dihydrodipicolinate synthase; Region: dapA; TIGR00674 509193004511 dimer interface [polypeptide binding]; other site 509193004512 active site 509193004513 catalytic residue [active] 509193004514 dihydrodipicolinate reductase; Provisional; Region: PRK00048 509193004515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193004516 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 509193004517 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 509193004518 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 509193004519 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 509193004520 putative trimer interface [polypeptide binding]; other site 509193004521 putative CoA binding site [chemical binding]; other site 509193004522 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 509193004523 homodimer interface [polypeptide binding]; other site 509193004524 Walker A motif; other site 509193004525 ATP binding site [chemical binding]; other site 509193004526 hydroxycobalamin binding site [chemical binding]; other site 509193004527 Walker B motif; other site 509193004528 single-stranded DNA-binding protein; Provisional; Region: PRK05813 509193004529 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 509193004530 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 509193004531 dimer interface [polypeptide binding]; other site 509193004532 ssDNA binding site [nucleotide binding]; other site 509193004533 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509193004534 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193004535 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 509193004536 putative peptidoglycan binding site; other site 509193004537 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 509193004538 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193004539 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193004540 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 509193004541 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 509193004542 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 509193004543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 509193004544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193004545 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193004546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 509193004547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193004548 dimer interface [polypeptide binding]; other site 509193004549 conserved gate region; other site 509193004550 putative PBP binding loops; other site 509193004551 ABC-ATPase subunit interface; other site 509193004552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193004553 dimer interface [polypeptide binding]; other site 509193004554 conserved gate region; other site 509193004555 putative PBP binding loops; other site 509193004556 ABC-ATPase subunit interface; other site 509193004557 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193004558 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193004559 DNA binding site [nucleotide binding] 509193004560 domain linker motif; other site 509193004561 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 509193004562 dimerization interface [polypeptide binding]; other site 509193004563 ligand binding site [chemical binding]; other site 509193004564 beta-phosphoglucomutase; Region: bPGM; TIGR01990 509193004565 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193004566 motif II; other site 509193004567 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 509193004568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193004569 dimer interface [polypeptide binding]; other site 509193004570 conserved gate region; other site 509193004571 putative PBP binding loops; other site 509193004572 ABC-ATPase subunit interface; other site 509193004573 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193004574 dimer interface [polypeptide binding]; other site 509193004575 conserved gate region; other site 509193004576 putative PBP binding loops; other site 509193004577 ABC-ATPase subunit interface; other site 509193004578 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 509193004579 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193004580 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 509193004581 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 509193004582 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193004583 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193004584 DNA binding site [nucleotide binding] 509193004585 domain linker motif; other site 509193004586 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 509193004587 dimerization interface [polypeptide binding]; other site 509193004588 ligand binding site [chemical binding]; other site 509193004589 iron-sulfur cluster binding protein, putative; Region: TIGR00276 509193004590 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 509193004591 Uncharacterized conserved protein [Function unknown]; Region: COG3391 509193004592 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 509193004593 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 509193004594 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193004595 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509193004596 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 509193004597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509193004598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 509193004599 Coenzyme A binding pocket [chemical binding]; other site 509193004600 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 509193004601 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509193004602 active site 509193004603 HIGH motif; other site 509193004604 nucleotide binding site [chemical binding]; other site 509193004605 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 509193004606 active site 509193004607 KMSKS motif; other site 509193004608 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 509193004609 tRNA binding surface [nucleotide binding]; other site 509193004610 anticodon binding site; other site 509193004611 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 509193004612 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 509193004613 BioY family; Region: BioY; cl00560 509193004614 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 509193004615 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 509193004616 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 509193004617 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509193004618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193004619 active site 509193004620 phosphorylation site [posttranslational modification] 509193004621 intermolecular recognition site; other site 509193004622 dimerization interface [polypeptide binding]; other site 509193004623 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 509193004624 DNA binding site [nucleotide binding] 509193004625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 509193004626 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 509193004627 dimerization interface [polypeptide binding]; other site 509193004628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 509193004629 dimer interface [polypeptide binding]; other site 509193004630 phosphorylation site [posttranslational modification] 509193004631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193004632 ATP binding site [chemical binding]; other site 509193004633 G-X-G motif; other site 509193004634 Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398 509193004635 Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398 509193004636 AIR carboxylase; Region: AIRC; cl00310 509193004637 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 509193004638 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 509193004639 Ligand Binding Site [chemical binding]; other site 509193004640 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 509193004641 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 509193004642 active site 509193004643 Protein of unknown function (DUF458); Region: DUF458; cl00861 509193004644 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 509193004645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193004646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 509193004647 putative substrate translocation pore; other site 509193004648 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193004649 putative substrate translocation pore; other site 509193004650 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 509193004651 active site 509193004652 multimer interface [polypeptide binding]; other site 509193004653 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 509193004654 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 509193004655 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 509193004656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193004657 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 509193004658 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 509193004659 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 509193004660 Uncharacterized membrane protein [Function unknown]; Region: COG3949 509193004661 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 509193004662 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 509193004663 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 509193004664 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 509193004665 Chain length determinant protein; Region: Wzz; cl01623 509193004666 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 509193004667 active site 509193004668 tetramer interface [polypeptide binding]; other site 509193004669 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 509193004670 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 509193004671 active site 509193004672 substrate binding site [chemical binding]; other site 509193004673 metal binding site [ion binding]; metal-binding site 509193004674 Transcription antiterminator [Transcription]; Region: NusG; COG0250 509193004675 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 509193004676 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 509193004677 Glutamine amidotransferase [Amino acid transport and metabolism]; Region: HisH; COG0118 509193004678 predicted active site [active] 509193004679 catalytic triad [active] 509193004680 pyridoxal biosynthesis lyase PdxS; Provisional; Region: PRK04180 509193004681 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 509193004682 active site 509193004683 multimer interface [polypeptide binding]; other site 509193004684 Protein of unknown function DUF86; Region: DUF86; cl01031 509193004685 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509193004686 active site 509193004687 NTP binding site [chemical binding]; other site 509193004688 metal binding triad [ion binding]; metal-binding site 509193004689 antibiotic binding site [chemical binding]; other site 509193004690 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 509193004691 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 509193004692 TIGR02680 family protein; Region: TIGR02680 509193004693 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 509193004694 TIGR02677 family protein; Region: TIGR02677 509193004695 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 509193004696 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509193004697 active site 509193004698 NTP binding site [chemical binding]; other site 509193004699 metal binding triad [ion binding]; metal-binding site 509193004700 antibiotic binding site [chemical binding]; other site 509193004701 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 509193004702 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 509193004703 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 509193004704 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 509193004705 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 509193004706 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 509193004707 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 509193004708 active site 509193004709 catalytic tetrad [active] 509193004710 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 509193004711 active site 509193004712 metal binding site [ion binding]; metal-binding site 509193004713 homotetramer interface [polypeptide binding]; other site 509193004714 LemA family; Region: LemA; cl00742 509193004715 Peptidase family M48; Region: Peptidase_M48; cl12018 509193004716 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 509193004717 Phd_YefM; Region: PhdYeFM; cl09153 509193004718 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193004719 MoxR-like ATPases [General function prediction only]; Region: COG0714 509193004720 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193004721 Walker A/P-loop; other site 509193004722 ATP binding site [chemical binding]; other site 509193004723 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 509193004724 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 509193004725 hypothetical protein; Reviewed; Region: PRK09588 509193004726 Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; cl01178 509193004727 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 509193004728 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 509193004729 Putative small multi-drug export protein; Region: Sm_multidrug_ex; cl01024 509193004730 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 509193004731 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 509193004732 DNA binding residues [nucleotide binding] 509193004733 putative dimer interface [polypeptide binding]; other site 509193004734 Cupin domain; Region: Cupin_2; cl09118 509193004735 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509193004736 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 509193004737 Domain of unknown function (DUF369); Region: DUF369; cl00950 509193004738 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 509193004739 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 509193004740 dimer interface [polypeptide binding]; other site 509193004741 active site 509193004742 metal binding site [ion binding]; metal-binding site 509193004743 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 509193004744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and...; Region: Aldo_ket_red; cd06660 509193004745 active site 509193004746 catalytic tetrad [active] 509193004747 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 509193004748 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 509193004749 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509193004750 active site 509193004751 NTP binding site [chemical binding]; other site 509193004752 metal binding triad [ion binding]; metal-binding site 509193004753 antibiotic binding site [chemical binding]; other site 509193004754 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 509193004755 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 509193004756 TIGR02680 family protein; Region: TIGR02680 509193004757 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 509193004758 TIGR02677 family protein; Region: TIGR02677 509193004759 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 509193004760 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 509193004761 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 509193004762 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 509193004763 active site 509193004764 NTP binding site [chemical binding]; other site 509193004765 metal binding triad [ion binding]; metal-binding site 509193004766 antibiotic binding site [chemical binding]; other site 509193004767 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 509193004768 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 509193004769 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 509193004770 active site 509193004771 metal binding site [ion binding]; metal-binding site 509193004772 homotetramer interface [polypeptide binding]; other site 509193004773 ATP cone domain; Region: ATP-cone; pfam03477 509193004774 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 509193004775 Chain length determinant protein; Region: Wzz; cl01623 509193004776 Chain length determinant protein; Region: Wzz; cl01623 509193004777 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 509193004778 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 509193004779 Substrate binding site [chemical binding]; other site 509193004780 Cupin domain; Region: Cupin_2; cl09118 509193004781 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 509193004782 Bacterial sugar transferase; Region: Bac_transf; cl00939 509193004783 Cupin domain; Region: Cupin_2; cl09118 509193004784 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 509193004785 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 509193004786 NADP binding site [chemical binding]; other site 509193004787 active site 509193004788 putative substrate binding site [chemical binding]; other site 509193004789 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 509193004790 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 509193004791 substrate binding site [chemical binding]; other site 509193004792 tetramer interface [polypeptide binding]; other site 509193004793 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 509193004794 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 509193004795 NAD binding site [chemical binding]; other site 509193004796 substrate binding site [chemical binding]; other site 509193004797 homodimer interface [polypeptide binding]; other site 509193004798 active site 509193004799 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 509193004800 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 509193004801 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 509193004802 Probable Catalytic site [active] 509193004803 metal binding site [ion binding]; metal-binding site 509193004804 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 509193004805 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 509193004806 active site 509193004807 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509193004808 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 509193004809 O-Antigen ligase; Region: Wzy_C; cl04850 509193004810 Probable transposase; Region: OrfB_IS605; pfam01385 509193004811 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 509193004812 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 509193004813 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 509193004814 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 509193004815 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 509193004816 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 509193004817 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 509193004818 MgtE intracellular N domain; Region: MgtE_N; cl15244 509193004819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 509193004820 Divalent cation transporter; Region: MgtE; cl00786 509193004821 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 509193004822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193004823 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 509193004824 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars...; Region: ABC_NrtD_SsuB_transporters; cd03293 509193004825 Walker A/P-loop; other site 509193004826 ATP binding site [chemical binding]; other site 509193004827 Q-loop/lid; other site 509193004828 ABC transporter signature motif; other site 509193004829 Walker B; other site 509193004830 D-loop; other site 509193004831 H-loop/switch region; other site 509193004832 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 509193004833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 509193004834 NAD synthetase; Provisional; Region: PRK13981 509193004835 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 509193004836 multimer interface [polypeptide binding]; other site 509193004837 active site 509193004838 catalytic triad [active] 509193004839 protein interface 1 [polypeptide binding]; other site 509193004840 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 509193004841 homodimer interface [polypeptide binding]; other site 509193004842 NAD binding pocket [chemical binding]; other site 509193004843 ATP binding pocket [chemical binding]; other site 509193004844 Mg binding site [ion binding]; other site 509193004845 active-site loop [active] 509193004846 EamA-like transporter family; Region: EamA; cl01037 509193004847 EamA-like transporter family; Region: EamA; cl01037 509193004848 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 509193004849 G1 box; other site 509193004850 GTP/Mg2+ binding site [chemical binding]; other site 509193004851 Switch I region; other site 509193004852 G2 box; other site 509193004853 G3 box; other site 509193004854 Switch II region; other site 509193004855 G4 box; other site 509193004856 G5 box; other site 509193004857 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 509193004858 Found in ATP-dependent protease La (LON); Region: LON; cl01056 509193004859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193004860 Walker A motif; other site 509193004861 ATP binding site [chemical binding]; other site 509193004862 Walker B motif; other site 509193004863 arginine finger; other site 509193004864 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 509193004865 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 509193004866 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 509193004867 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193004868 Walker A motif; other site 509193004869 ATP binding site [chemical binding]; other site 509193004870 Walker B motif; other site 509193004871 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 509193004872 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 509193004873 oligomer interface [polypeptide binding]; other site 509193004874 active site residues [active] 509193004875 trigger factor; Provisional; Region: tig; PRK01490 509193004876 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 509193004877 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 509193004878 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 509193004879 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 509193004880 substrate binding site [chemical binding]; other site 509193004881 multimerization interface [polypeptide binding]; other site 509193004882 ATP binding site [chemical binding]; other site 509193004883 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 509193004884 thiamine phosphate binding site [chemical binding]; other site 509193004885 active site 509193004886 pyrophosphate binding site [ion binding]; other site 509193004887 bifunctional hydroxy-methylpyrimidine kinase/ hydroxy-phosphomethylpyrimidine kinase; Reviewed; Region: PRK06427 509193004888 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 509193004889 dimer interface [polypeptide binding]; other site 509193004890 substrate binding site [chemical binding]; other site 509193004891 ATP binding site [chemical binding]; other site 509193004892 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous...; Region: arch_gltB; cd00981 509193004893 putative subunit interface; other site 509193004894 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 509193004895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193004896 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193004897 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 509193004898 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 509193004899 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 509193004900 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 509193004901 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 509193004902 active site 509193004903 FMN binding site [chemical binding]; other site 509193004904 substrate binding site [chemical binding]; other site 509193004905 3Fe-4S cluster binding site [ion binding]; other site 509193004906 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 509193004907 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 509193004908 putative active site [active] 509193004909 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 509193004910 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 509193004911 catalytic triad [active] 509193004912 Nitrogen regulatory protein P-II; Region: P-II; cl00412 509193004913 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 509193004914 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 509193004915 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 509193004916 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 509193004917 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 509193004918 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 509193004919 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 509193004920 Protein of unknown function, DUF1537; Region: DUF1537; cl01345 509193004921 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 509193004922 SAF domain; Region: SAF; cl00555 509193004923 SAF domain; Region: SAF; cl00555 509193004924 Propionate catabolism activator; Region: PrpR_N; pfam06506 509193004925 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 509193004926 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 509193004927 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193004928 Walker A motif; other site 509193004929 ATP binding site [chemical binding]; other site 509193004930 Walker B motif; other site 509193004931 arginine finger; other site 509193004932 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 509193004933 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509193004934 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 509193004935 active site 509193004936 metal binding site [ion binding]; metal-binding site 509193004937 homotetramer interface [polypeptide binding]; other site 509193004938 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 509193004939 active site 509193004940 dimerization interface [polypeptide binding]; other site 509193004941 ribonuclease PH; Reviewed; Region: rph; PRK00173 509193004942 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 509193004943 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 509193004944 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 509193004945 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193004946 Walker A/P-loop; other site 509193004947 ATP binding site [chemical binding]; other site 509193004948 Q-loop/lid; other site 509193004949 ABC transporter signature motif; other site 509193004950 Walker B; other site 509193004951 D-loop; other site 509193004952 H-loop/switch region; other site 509193004953 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193004954 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 509193004955 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193004956 Walker A/P-loop; other site 509193004957 ATP binding site [chemical binding]; other site 509193004958 Q-loop/lid; other site 509193004959 ABC transporter signature motif; other site 509193004960 Walker B; other site 509193004961 D-loop; other site 509193004962 H-loop/switch region; other site 509193004963 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193004964 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 509193004965 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 509193004966 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193004967 dimer interface [polypeptide binding]; other site 509193004968 conserved gate region; other site 509193004969 putative PBP binding loops; other site 509193004970 ABC-ATPase subunit interface; other site 509193004971 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 509193004972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193004973 dimer interface [polypeptide binding]; other site 509193004974 conserved gate region; other site 509193004975 putative PBP binding loops; other site 509193004976 ABC-ATPase subunit interface; other site 509193004977 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 509193004978 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 509193004979 peptide binding site [polypeptide binding]; other site 509193004980 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 509193004981 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 509193004982 GatB domain; Region: GatB_Yqey; cl11497 509193004983 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 509193004984 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 509193004985 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 509193004986 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 509193004987 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 509193004988 nucleotide binding pocket [chemical binding]; other site 509193004989 K-X-D-G motif; other site 509193004990 catalytic site [active] 509193004991 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 509193004992 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 509193004993 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 509193004994 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 509193004995 Dimer interface [polypeptide binding]; other site 509193004996 BRCT sequence motif; other site 509193004997 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 509193004998 UvrD/REP helicase; Region: UvrD-helicase; cl14126 509193004999 Trp repressor protein; Region: Trp_repressor; cl01121 509193005000 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 509193005001 methionine cluster; other site 509193005002 active site 509193005003 phosphorylation site [posttranslational modification] 509193005004 metal binding site [ion binding]; metal-binding site 509193005005 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 509193005006 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 509193005007 active site 509193005008 P-loop; other site 509193005009 phosphorylation site [posttranslational modification] 509193005010 Predicted transcriptional regulator [Transcription]; Region: COG2378 509193005011 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005012 PRD domain; Region: PRD; pfam00874 509193005013 PRD domain; Region: PRD; pfam00874 509193005014 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 509193005015 P-loop; other site 509193005016 active site 509193005017 phosphorylation site [posttranslational modification] 509193005018 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 509193005019 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 509193005020 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 509193005021 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 509193005022 stage V sporulation protein B; Region: spore_V_B; TIGR02900 509193005023 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 509193005024 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 509193005025 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 509193005026 metal binding site [ion binding]; metal-binding site 509193005027 dimer interface [polypeptide binding]; other site 509193005028 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 509193005029 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 509193005030 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 509193005031 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193005032 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 509193005033 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 509193005034 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 509193005035 purine monophosphate binding site [chemical binding]; other site 509193005036 dimer interface [polypeptide binding]; other site 509193005037 putative catalytic residues [active] 509193005038 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 509193005039 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 509193005040 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 509193005041 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 509193005042 active site 509193005043 substrate binding site [chemical binding]; other site 509193005044 cosubstrate binding site; other site 509193005045 catalytic site [active] 509193005046 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 509193005047 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 509193005048 dimerization interface [polypeptide binding]; other site 509193005049 putative ATP binding site [chemical binding]; other site 509193005050 amidophosphoribosyltransferase; Provisional; Region: PRK05793 509193005051 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 509193005052 active site 509193005053 tetramer interface [polypeptide binding]; other site 509193005054 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193005055 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 509193005056 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 509193005057 dimerization interface [polypeptide binding]; other site 509193005058 ATP binding site [chemical binding]; other site 509193005059 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 509193005060 dimerization interface [polypeptide binding]; other site 509193005061 ATP binding site [chemical binding]; other site 509193005062 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 509193005063 putative active site [active] 509193005064 catalytic triad [active] 509193005065 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 509193005066 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 509193005067 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 509193005068 ATP binding site [chemical binding]; other site 509193005069 active site 509193005070 substrate binding site [chemical binding]; other site 509193005071 AIR carboxylase; Region: AIRC; cl00310 509193005072 Sulfate transporter family; Region: Sulfate_transp; cl00967 509193005073 Permease family; Region: Xan_ur_permease; pfam00860 509193005074 GMP synthase; Reviewed; Region: guaA; PRK00074 509193005075 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 509193005076 AMP/PPi binding site [chemical binding]; other site 509193005077 candidate oxyanion hole; other site 509193005078 catalytic triad [active] 509193005079 potential glutamine specificity residues [chemical binding]; other site 509193005080 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 509193005081 ATP Binding subdomain [chemical binding]; other site 509193005082 Ligand Binding sites [chemical binding]; other site 509193005083 Dimerization subdomain; other site 509193005084 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 509193005085 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 509193005086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 509193005087 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 509193005088 active site 509193005089 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 509193005090 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 509193005091 ring oligomerisation interface [polypeptide binding]; other site 509193005092 ATP/Mg binding site [chemical binding]; other site 509193005093 stacking interactions; other site 509193005094 hinge regions; other site 509193005095 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 509193005096 oligomerisation interface [polypeptide binding]; other site 509193005097 mobile loop; other site 509193005098 roof hairpin; other site 509193005099 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 509193005100 active site 509193005101 catalytic triad [active] 509193005102 HutP; Region: HutP; cl07944 509193005103 Protein of unknown function (DUF554); Region: DUF554; cl00784 509193005104 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 509193005105 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 509193005106 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 509193005107 minor groove reading motif; other site 509193005108 helix-hairpin-helix signature motif; other site 509193005109 substrate binding pocket [chemical binding]; other site 509193005110 active site 509193005111 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 509193005112 phosphate binding site [ion binding]; other site 509193005113 putative oxidoreductase; Provisional; Region: PRK12831 509193005114 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193005115 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193005116 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 509193005117 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-...; Region: DHOD_e_trans_like1; cd06219 509193005118 FAD binding pocket [chemical binding]; other site 509193005119 FAD binding motif [chemical binding]; other site 509193005120 phosphate binding motif [ion binding]; other site 509193005121 beta-alpha-beta structure motif; other site 509193005122 NAD binding pocket [chemical binding]; other site 509193005123 Iron coordination center [ion binding]; other site 509193005124 Protein of unknown function (DUF322); Region: DUF322; cl00574 509193005125 Accessory gene regulator B; Region: AgrB; cl01873 509193005126 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 509193005127 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193005128 ATP binding site [chemical binding]; other site 509193005129 Mg2+ binding site [ion binding]; other site 509193005130 G-X-G motif; other site 509193005131 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 509193005132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193005133 active site 509193005134 phosphorylation site [posttranslational modification] 509193005135 intermolecular recognition site; other site 509193005136 dimerization interface [polypeptide binding]; other site 509193005137 LytTr DNA-binding domain; Region: LytTR; cl04498 509193005138 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 509193005139 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 509193005140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193005141 flagellar motor protein MotS; Reviewed; Region: PRK06925 509193005142 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 509193005143 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 509193005144 ligand binding site [chemical binding]; other site 509193005145 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 509193005146 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 509193005147 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 509193005148 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193005149 UGMP family protein; Validated; Region: PRK09604 509193005150 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 509193005151 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 509193005152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 509193005153 Coenzyme A binding pocket [chemical binding]; other site 509193005154 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 509193005155 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 509193005156 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 509193005157 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 509193005158 carbamate kinase; Reviewed; Region: PRK12686 509193005159 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 509193005160 putative substrate binding site [chemical binding]; other site 509193005161 nucleotide binding site [chemical binding]; other site 509193005162 nucleotide binding site [chemical binding]; other site 509193005163 homodimer interface [polypeptide binding]; other site 509193005164 ornithine carbamoyltransferase; Validated; Region: PRK02102 509193005165 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 509193005166 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 509193005167 Amidinotransferase; Region: Amidinotransf; cl12043 509193005168 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 509193005169 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509193005170 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 509193005171 active site 509193005172 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509193005173 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 509193005174 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 509193005175 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 509193005176 Uncharacterised protein family (UPF0081); Region: UPF0081; cl00525 509193005177 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin...; Region: S1_Tex; cd05685 509193005178 RNA binding site [nucleotide binding]; other site 509193005179 peptide chain release factor 2; Validated; Region: prfB; PRK00578 509193005180 RF-1 domain; Region: RF-1; cl02875 509193005181 RF-1 domain; Region: RF-1; cl02875 509193005182 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 509193005183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl14882 509193005184 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 509193005185 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 509193005186 nucleotide binding region [chemical binding]; other site 509193005187 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 509193005188 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 509193005189 Transposase; Region: DDE_Tnp_ISL3; pfam01610 509193005190 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 509193005191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005192 3H domain; Region: 3H; pfam02829 509193005193 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 509193005194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193005195 Zn2+ binding site [ion binding]; other site 509193005196 Mg2+ binding site [ion binding]; other site 509193005197 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 509193005198 30S subunit binding site; other site 509193005199 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 509193005200 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 509193005201 Walker A/P-loop; other site 509193005202 ATP binding site [chemical binding]; other site 509193005203 Q-loop/lid; other site 509193005204 ABC transporter signature motif; other site 509193005205 Walker B; other site 509193005206 D-loop; other site 509193005207 H-loop/switch region; other site 509193005208 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 509193005209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193005210 dimer interface [polypeptide binding]; other site 509193005211 conserved gate region; other site 509193005212 putative PBP binding loops; other site 509193005213 ABC-ATPase subunit interface; other site 509193005214 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 509193005215 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 509193005216 substrate binding pocket [chemical binding]; other site 509193005217 membrane-bound complex binding site; other site 509193005218 hinge residues; other site 509193005219 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 509193005220 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193005221 putative active site [active] 509193005222 putative NTP binding site [chemical binding]; other site 509193005223 putative nucleic acid binding site [nucleotide binding]; other site 509193005224 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193005225 Cache domain; Region: Cache_1; pfam02743 509193005226 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 509193005227 dimerization interface [polypeptide binding]; other site 509193005228 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 509193005229 Flagellar protein FliS; Region: FliS; cl00654 509193005230 flagellar capping protein; Validated; Region: fliD; PRK07737 509193005231 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 509193005232 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 509193005233 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 509193005234 FlaG protein; Region: FlaG; cl00591 509193005235 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 509193005236 active site 509193005237 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 509193005238 dimer interface [polypeptide binding]; other site 509193005239 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 509193005240 Ligand Binding Site [chemical binding]; other site 509193005241 Molecular Tunnel; other site 509193005242 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193005243 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193005244 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193005245 DpnII restriction endonuclease; Region: DpnII; pfam04556 509193005246 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl00408 509193005247 LAGLIDADG DNA endonuclease family; Region: LAGLIDADG_2; pfam03161 509193005248 flagellin; Reviewed; Region: PRK08869 509193005249 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509193005250 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509193005251 Global regulator protein family; Region: CsrA; cl00670 509193005252 FliW protein; Region: FliW; cl00740 509193005253 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 509193005254 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 509193005255 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 509193005256 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 509193005257 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 509193005258 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 509193005259 FlgN protein; Region: FlgN; cl09176 509193005260 flagellar operon protein TIGR03826; Region: YvyF 509193005261 DNA utilization protein GntX; Provisional; Region: PRK11595 509193005262 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193005263 RecD/TraA family; Region: recD_rel; TIGR01448 509193005264 UvrD/REP helicase; Region: UvrD-helicase; cl14126 509193005265 UvrD/REP helicase; Region: UvrD-helicase; cl14126 509193005266 S-adenosylmethionine synthetase; Validated; Region: PRK05250 509193005267 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 509193005268 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 509193005269 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 509193005270 Rubrerythrin [Energy production and conversion]; Region: COG1592 509193005271 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 509193005272 binuclear metal center [ion binding]; other site 509193005273 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and ferredoxin-...; Region: rubredoxin_SM; cd00729 509193005274 iron binding site [ion binding]; other site 509193005275 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 509193005276 Sporulation and spore germination; Region: Germane; pfam10646 509193005277 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 509193005278 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 509193005279 dimerization interface [polypeptide binding]; other site 509193005280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 509193005281 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 509193005282 dimer interface [polypeptide binding]; other site 509193005283 phosphorylation site [posttranslational modification] 509193005284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 509193005285 ATP binding site [chemical binding]; other site 509193005286 Mg2+ binding site [ion binding]; other site 509193005287 G-X-G motif; other site 509193005288 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 509193005289 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193005290 active site 509193005291 phosphorylation site [posttranslational modification] 509193005292 intermolecular recognition site; other site 509193005293 dimerization interface [polypeptide binding]; other site 509193005294 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 509193005295 DNA binding site [nucleotide binding] 509193005296 catabolite control protein A; Region: ccpA; TIGR01481 509193005297 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193005298 DNA binding site [nucleotide binding] 509193005299 domain linker motif; other site 509193005300 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 509193005301 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 509193005302 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 509193005303 active site 509193005304 motif I; other site 509193005305 motif II; other site 509193005306 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 509193005307 Protein of unknown function (DUF421); Region: DUF421; cl00990 509193005308 Oxalate/Formate Antiporter; Region: 2A0111; TIGR00890 509193005309 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193005310 putative substrate translocation pore; other site 509193005311 AIR carboxylase; Region: AIRC; cl00310 509193005312 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 509193005313 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193005314 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 509193005315 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 509193005316 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193005317 Uncharacterized conserved protein [Function unknown]; Region: COG5495 509193005318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193005319 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 509193005320 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 509193005321 oligomerization interface [polypeptide binding]; other site 509193005322 active site 509193005323 metal binding site [ion binding]; metal-binding site 509193005324 pantoate--beta-alanine ligase; Region: panC; TIGR00018 509193005325 Pantoate-beta-alanine ligase; Region: PanC; cd00560 509193005326 active site 509193005327 ATP-binding site [chemical binding]; other site 509193005328 pantoate-binding site; other site 509193005329 HXXH motif; other site 509193005330 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 509193005331 tetramerization interface [polypeptide binding]; other site 509193005332 active site 509193005333 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 509193005334 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 509193005335 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 509193005336 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 509193005337 phosphate binding site [ion binding]; other site 509193005338 Protein of unknown function (DUF3607); Region: DUF3607; pfam12245 509193005339 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 509193005340 aconitate hydratase; Validated; Region: PRK07229 509193005341 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 509193005342 substrate binding site [chemical binding]; other site 509193005343 ligand binding site [chemical binding]; other site 509193005344 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 509193005345 substrate binding site [chemical binding]; other site 509193005346 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 509193005347 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 509193005348 active site 509193005349 catalytic residues [active] 509193005350 metal binding site [ion binding]; metal-binding site 509193005351 CAT RNA binding domain; Region: CAT_RBD; pfam03123 509193005352 transcriptional antiterminator BglG; Provisional; Region: PRK09772 509193005353 PRD domain; Region: PRD; pfam00874 509193005354 PRD domain; Region: PRD; pfam00874 509193005355 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_glc; cl00162 509193005356 HPr interaction site; other site 509193005357 glycerol kinase (GK) interaction site [polypeptide binding]; other site 509193005358 active site 509193005359 phosphorylation site [posttranslational modification] 509193005360 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 509193005361 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIB_glc; cd00212 509193005362 active site turn [active] 509193005363 phosphorylation site [posttranslational modification] 509193005364 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 509193005365 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 509193005366 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 509193005367 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 509193005368 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 509193005369 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 509193005370 Sulfatase; Region: Sulfatase; cl10460 509193005371 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 509193005372 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 509193005373 active site 509193005374 catalytic motif [active] 509193005375 Zn binding site [ion binding]; other site 509193005376 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 509193005377 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509193005378 DNA-binding site [nucleotide binding]; DNA binding site 509193005379 UTRA domain; Region: UTRA; cl06649 509193005380 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 509193005381 TM-ABC transporter signature motif; other site 509193005382 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (; Region: TM_PBP1_transp_TpRbsC_like; cd06580 509193005383 TM-ABC transporter signature motif; other site 509193005384 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 509193005385 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 509193005386 Walker A/P-loop; other site 509193005387 ATP binding site [chemical binding]; other site 509193005388 Q-loop/lid; other site 509193005389 ABC transporter signature motif; other site 509193005390 Walker B; other site 509193005391 D-loop; other site 509193005392 H-loop/switch region; other site 509193005393 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 509193005394 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 509193005395 ligand binding site [chemical binding]; other site 509193005396 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 509193005397 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509193005398 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria...; Region: Imidazolone-5PH; cd01296 509193005399 active site 509193005400 glutamate formiminotransferase; Region: FtcD; TIGR02024 509193005401 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 509193005402 Formiminotransferase domain; Region: FTCD; pfam02971 509193005403 urocanate hydratase; Provisional; Region: PRK05414 509193005404 urocanate hydratase; Region: hutU; TIGR01228 509193005405 Cache domain; Region: Cache_1; pfam02743 509193005406 proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785 509193005407 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 509193005408 dimerization interface [polypeptide binding]; other site 509193005409 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 509193005410 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 509193005411 Transposase domain (DUF772); Region: DUF772; cl12084 509193005412 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 509193005413 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193005414 Zn2+ binding site [ion binding]; other site 509193005415 Mg2+ binding site [ion binding]; other site 509193005416 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 509193005417 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 509193005418 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 509193005419 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 509193005420 dimer interface [polypeptide binding]; other site 509193005421 PYR/PP interface [polypeptide binding]; other site 509193005422 TPP binding site [chemical binding]; other site 509193005423 substrate binding site [chemical binding]; other site 509193005424 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 509193005425 Domain of unknown function; Region: EKR; pfam10371 509193005426 4Fe-4S binding domain; Region: Fer4; cl02805 509193005427 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 509193005428 TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This subfamily also includes proteins characterized as...; Region: TPP_PFOR_PNO; cd03377 509193005429 TPP-binding site [chemical binding]; other site 509193005430 dimer interface [polypeptide binding]; other site 509193005431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 509193005432 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 509193005433 Transposase; Region: DDE_Tnp_ISL3; pfam01610 509193005434 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 509193005435 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 509193005436 oligomer interface [polypeptide binding]; other site 509193005437 active site 509193005438 metal binding site [ion binding]; metal-binding site 509193005439 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 509193005440 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 509193005441 oligomer interface [polypeptide binding]; other site 509193005442 active site 509193005443 metal binding site [ion binding]; metal-binding site 509193005444 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 509193005445 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 509193005446 oligomer interface [polypeptide binding]; other site 509193005447 active site 509193005448 metal binding site [ion binding]; metal-binding site 509193005449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 509193005450 DNA-binding site [nucleotide binding]; DNA binding site 509193005451 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 509193005452 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 509193005453 Walker A/P-loop; other site 509193005454 ATP binding site [chemical binding]; other site 509193005455 Q-loop/lid; other site 509193005456 ABC transporter signature motif; other site 509193005457 Walker B; other site 509193005458 D-loop; other site 509193005459 H-loop/switch region; other site 509193005460 Peptidase M15; Region: Peptidase_M15_3; cl01194 509193005461 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 509193005462 photosystem II stability/assembly factor; Provisional; Region: PLN00033 509193005463 Ycf48-like protein; Provisional; Region: PRK13684 509193005464 Ycf48-like protein; Provisional; Region: PRK13684 509193005465 Membrane transport protein; Region: Mem_trans; cl09117 509193005466 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 509193005467 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509193005468 Protein of unknown function (DUF429); Region: DUF429; cl12046 509193005469 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 509193005470 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 509193005471 putative active site [active] 509193005472 putative NTP binding site [chemical binding]; other site 509193005473 putative nucleic acid binding site [nucleotide binding]; other site 509193005474 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 509193005475 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 509193005476 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193005477 Integrase core domain; Region: rve; cl01316 509193005478 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 509193005479 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 509193005480 diiron binding motif [ion binding]; other site 509193005481 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 509193005482 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 509193005483 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 509193005484 oligomer interface [polypeptide binding]; other site 509193005485 active site 509193005486 metal binding site [ion binding]; metal-binding site 509193005487 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 509193005488 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 509193005489 oligomer interface [polypeptide binding]; other site 509193005490 active site 509193005491 metal binding site [ion binding]; metal-binding site 509193005492 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 509193005493 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 509193005494 oligomer interface [polypeptide binding]; other site 509193005495 active site 509193005496 metal binding site [ion binding]; metal-binding site 509193005497 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 509193005498 Membrane transport protein; Region: Mem_trans; cl09117 509193005499 Rhomboid family; Region: Rhomboid; cl11446 509193005500 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 509193005501 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13636 509193005502 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 509193005503 Walker A/P-loop; other site 509193005504 ATP binding site [chemical binding]; other site 509193005505 Q-loop/lid; other site 509193005506 ABC transporter signature motif; other site 509193005507 Walker B; other site 509193005508 D-loop; other site 509193005509 H-loop/switch region; other site 509193005510 Cobalt transport protein; Region: CbiQ; cl00463 509193005511 Cobalt transport protein component CbiN; Region: CbiN; cl00842 509193005512 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 509193005513 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 509193005514 precorrin-2 dehydrogenase; Validated; Region: PRK06719 509193005515 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 509193005516 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 509193005517 inhibitor-cofactor binding pocket; inhibition site 509193005518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193005519 catalytic residue [active] 509193005520 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 509193005521 dimer interface [polypeptide binding]; other site 509193005522 active site 509193005523 Schiff base residues; other site 509193005524 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 509193005525 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 509193005526 active site 509193005527 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 509193005528 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 509193005529 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 509193005530 homotrimer interface [polypeptide binding]; other site 509193005531 Walker A motif; other site 509193005532 GTP binding site [chemical binding]; other site 509193005533 Walker B motif; other site 509193005534 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 509193005535 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509193005536 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193005537 homodimer interface [polypeptide binding]; other site 509193005538 catalytic residue [active] 509193005539 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 509193005540 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 509193005541 CobD/Cbib protein; Region: CobD_Cbib; cl00561 509193005542 cobyric acid synthase; Provisional; Region: PRK00784 509193005543 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 509193005544 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 509193005545 catalytic triad [active] 509193005546 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 509193005547 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 509193005548 catalytic triad [active] 509193005549 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 509193005550 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 509193005551 Walker A/P-loop; other site 509193005552 ATP binding site [chemical binding]; other site 509193005553 Q-loop/lid; other site 509193005554 ABC transporter signature motif; other site 509193005555 Walker B; other site 509193005556 D-loop; other site 509193005557 H-loop/switch region; other site 509193005558 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 509193005559 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 509193005560 ABC-ATPase subunit interface; other site 509193005561 dimer interface [polypeptide binding]; other site 509193005562 putative PBP binding regions; other site 509193005563 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 509193005564 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 509193005565 putative binding site residues; other site 509193005566 PemK-like protein; Region: PemK; cl00995 509193005567 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 509193005568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193005569 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 509193005570 putative active site [active] 509193005571 Domain of unknown function (DUF477); Region: DUF477; cl01535 509193005572 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 509193005573 trimerization site [polypeptide binding]; other site 509193005574 active site 509193005575 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 509193005576 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 509193005577 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509193005578 catalytic residue [active] 509193005579 Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007 509193005580 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 509193005581 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 509193005582 4Fe-4S binding domain; Region: Fer4; cl02805 509193005583 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 509193005584 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 509193005585 FAD binding pocket [chemical binding]; other site 509193005586 FAD binding motif [chemical binding]; other site 509193005587 phosphate binding motif [ion binding]; other site 509193005588 beta-alpha-beta structure motif; other site 509193005589 NAD binding pocket [chemical binding]; other site 509193005590 Iron coordination center [ion binding]; other site 509193005591 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 509193005592 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 509193005593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005594 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 509193005595 putative dimerization interface [polypeptide binding]; other site 509193005596 LemA family; Region: LemA; cl00742 509193005597 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 509193005598 Protein of unknown function DUF58; Region: DUF58; pfam01882 509193005599 MoxR-like ATPases [General function prediction only]; Region: COG0714 509193005600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193005601 Walker A motif; other site 509193005602 ATP binding site [chemical binding]; other site 509193005603 Walker B motif; other site 509193005604 arginine finger; other site 509193005605 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 509193005606 metal binding site 2 [ion binding]; metal-binding site 509193005607 putative DNA binding helix; other site 509193005608 metal binding site 1 [ion binding]; metal-binding site 509193005609 dimer interface [polypeptide binding]; other site 509193005610 structural Zn2+ binding site [ion binding]; other site 509193005611 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 509193005612 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 509193005613 metal binding site [ion binding]; metal-binding site 509193005614 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 509193005615 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 509193005616 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 509193005617 ABC-ATPase subunit interface; other site 509193005618 dimer interface [polypeptide binding]; other site 509193005619 putative PBP binding regions; other site 509193005620 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 509193005621 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 509193005622 domain; Region: Glyco_hydro_2; pfam00703 509193005623 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 509193005624 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 509193005625 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193005626 Walker A/P-loop; other site 509193005627 ATP binding site [chemical binding]; other site 509193005628 Q-loop/lid; other site 509193005629 ABC transporter signature motif; other site 509193005630 Walker B; other site 509193005631 D-loop; other site 509193005632 H-loop/switch region; other site 509193005633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193005634 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 509193005635 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193005636 Walker A/P-loop; other site 509193005637 ATP binding site [chemical binding]; other site 509193005638 Q-loop/lid; other site 509193005639 ABC transporter signature motif; other site 509193005640 Walker B; other site 509193005641 D-loop; other site 509193005642 H-loop/switch region; other site 509193005643 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193005644 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 509193005645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193005646 putative PBP binding loops; other site 509193005647 ABC-ATPase subunit interface; other site 509193005648 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 509193005649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193005650 dimer interface [polypeptide binding]; other site 509193005651 conserved gate region; other site 509193005652 putative PBP binding loops; other site 509193005653 ABC-ATPase subunit interface; other site 509193005654 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 509193005655 substrate binding site [chemical binding]; other site 509193005656 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 509193005657 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193005658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193005659 DNA binding site [nucleotide binding] 509193005660 domain linker motif; other site 509193005661 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 509193005662 dimerization interface [polypeptide binding]; other site 509193005663 ligand binding site [chemical binding]; other site 509193005664 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 509193005665 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 509193005666 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 509193005667 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 509193005668 FMN binding site [chemical binding]; other site 509193005669 active site 509193005670 catalytic residues [active] 509193005671 substrate binding site [chemical binding]; other site 509193005672 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 509193005673 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 509193005674 active site 509193005675 metal binding site [ion binding]; metal-binding site 509193005676 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 509193005677 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 509193005678 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 509193005679 active site 509193005680 metal binding site [ion binding]; metal-binding site 509193005681 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 509193005682 Bacterial SH3 domain; Region: SH3_3; cl02551 509193005683 Bacterial SH3 domain; Region: SH3_3; cl02551 509193005684 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 509193005685 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 509193005686 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 509193005687 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509193005688 active site 509193005689 phosphorylation site [posttranslational modification] 509193005690 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 509193005691 PRD domain; Region: PRD; pfam00874 509193005692 PRD domain; Region: PRD; pfam00874 509193005693 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 509193005694 P-loop; other site 509193005695 active site 509193005696 phosphorylation site [posttranslational modification] 509193005697 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 509193005698 active site 509193005699 phosphorylation site [posttranslational modification] 509193005700 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 509193005701 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 509193005702 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_mannitol; cd05567 509193005703 active site 509193005704 P-loop; other site 509193005705 phosphorylation site [posttranslational modification] 509193005706 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 509193005707 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 509193005708 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 509193005709 NAD binding site [chemical binding]; other site 509193005710 sugar binding site [chemical binding]; other site 509193005711 divalent metal binding site [ion binding]; other site 509193005712 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509193005713 dimer interface [polypeptide binding]; other site 509193005714 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 509193005715 methionine cluster; other site 509193005716 active site 509193005717 phosphorylation site [posttranslational modification] 509193005718 metal binding site [ion binding]; metal-binding site 509193005719 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N,N-...; Region: PTS_IIB_chitobiose_lichenan; cd05564 509193005720 active site 509193005721 P-loop; other site 509193005722 phosphorylation site [posttranslational modification] 509193005723 YdjC-like protein; Region: YdjC; cl01344 509193005724 Phosphotransferase system, EIIC; Region: PTS_EIIC; cl00557 509193005725 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 509193005726 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193005727 Walker B motif; other site 509193005728 arginine finger; other site 509193005729 PRD domain; Region: PRD; pfam00874 509193005730 Transcriptional antiterminator [Transcription]; Region: COG3933 509193005731 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 509193005732 active pocket/dimerization site; other site 509193005733 active site 509193005734 phosphorylation site [posttranslational modification] 509193005735 PRD domain; Region: PRD; pfam00874 509193005736 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 509193005737 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 509193005738 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 509193005739 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 509193005740 putative kinase; Provisional; Region: PRK09954 509193005741 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005742 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 509193005743 substrate binding site [chemical binding]; other site 509193005744 ATP binding site [chemical binding]; other site 509193005745 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 509193005746 AzlC protein; Region: AzlC; cl00570 509193005747 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 509193005748 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 509193005749 HIGH motif; other site 509193005750 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 509193005751 active site 509193005752 KMSKS motif; other site 509193005753 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 509193005754 tRNA binding surface [nucleotide binding]; other site 509193005755 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 509193005756 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 509193005757 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 509193005758 Walker A/P-loop; other site 509193005759 ATP binding site [chemical binding]; other site 509193005760 Q-loop/lid; other site 509193005761 ABC transporter signature motif; other site 509193005762 Walker B; other site 509193005763 D-loop; other site 509193005764 H-loop/switch region; other site 509193005765 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193005766 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 509193005767 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 509193005768 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 509193005769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 509193005770 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 509193005771 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 509193005772 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 509193005773 Ferredoxin [Energy production and conversion]; Region: COG1146 509193005774 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 509193005775 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 509193005776 dimerization interface [polypeptide binding]; other site 509193005777 putative DNA binding site [nucleotide binding]; other site 509193005778 putative Zn2+ binding site [ion binding]; other site 509193005779 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 509193005780 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193005781 Entner-Doudoroff aldolase; Region: eda; TIGR01182 509193005782 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509193005783 active site 509193005784 intersubunit interface [polypeptide binding]; other site 509193005785 catalytic residue [active] 509193005786 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 509193005787 substrate binding site [chemical binding]; other site 509193005788 ATP binding site [chemical binding]; other site 509193005789 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 509193005790 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 509193005791 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 509193005792 Entner-Doudoroff aldolase; Region: eda; TIGR01182 509193005793 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509193005794 active site 509193005795 intersubunit interface [polypeptide binding]; other site 509193005796 catalytic residue [active] 509193005797 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005798 Transcriptional regulator [Transcription]; Region: IclR; COG1414 509193005799 Bacterial transcriptional regulator; Region: IclR; pfam01614 509193005800 Domain of unknown function (DUF2088); Region: DUF2088; pfam09861 509193005801 Transglycosylase; Region: Transgly; cl07896 509193005802 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 509193005803 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 509193005804 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 509193005805 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 509193005806 dimer interface [polypeptide binding]; other site 509193005807 active site 509193005808 metal binding site [ion binding]; metal-binding site 509193005809 hypothetical protein; Provisional; Region: PRK02947 509193005810 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose...; Region: SIS_RpiR; cd05013 509193005811 putative active site [active] 509193005812 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 509193005813 P-loop; other site 509193005814 active site 509193005815 phosphorylation site [posttranslational modification] 509193005816 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 509193005817 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 509193005818 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005820 PRD domain; Region: PRD; pfam00874 509193005821 PRD domain; Region: PRD; pfam00874 509193005822 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 509193005823 P-loop; other site 509193005824 active site 509193005825 phosphorylation site [posttranslational modification] 509193005826 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509193005827 active site 509193005828 phosphorylation site [posttranslational modification] 509193005829 aspartate aminotransferase; Provisional; Region: PRK08361 509193005830 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509193005831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193005832 homodimer interface [polypeptide binding]; other site 509193005833 catalytic residue [active] 509193005834 OsmC-like protein; Region: OsmC; cl00767 509193005835 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509193005836 E3 interaction surface; other site 509193005837 lipoyl attachment site [posttranslational modification]; other site 509193005838 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 509193005839 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193005840 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509193005841 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 509193005842 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 509193005843 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 509193005844 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 509193005845 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 509193005846 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 509193005847 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 509193005848 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 509193005849 lipoyl attachment site [posttranslational modification]; other site 509193005850 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 509193005851 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 509193005852 tetramer interface [polypeptide binding]; other site 509193005853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193005854 catalytic residue [active] 509193005855 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 509193005856 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2...; Region: GDC-P; cd00613 509193005857 tetramer interface [polypeptide binding]; other site 509193005858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193005859 catalytic residue [active] 509193005860 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 509193005861 Domain of unknown function (DUF296); Region: DUF296; cl00720 509193005862 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 509193005863 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193005864 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 509193005865 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193005866 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 509193005867 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 509193005868 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 509193005869 NAD binding site [chemical binding]; other site 509193005870 dimer interface [polypeptide binding]; other site 509193005871 substrate binding site [chemical binding]; other site 509193005872 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509193005873 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 509193005874 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 509193005875 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 509193005876 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 509193005877 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 509193005878 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 509193005879 ADP-glucose phosphorylase; Region: PLN02643 509193005880 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 509193005881 dimer interface [polypeptide binding]; other site 509193005882 active site 509193005883 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 509193005884 metal binding site 2 [ion binding]; metal-binding site 509193005885 putative DNA binding helix; other site 509193005886 metal binding site 1 [ion binding]; metal-binding site 509193005887 dimer interface [polypeptide binding]; other site 509193005888 structural Zn2+ binding site [ion binding]; other site 509193005889 putative peroxiredoxin; Provisional; Region: PRK13599 509193005890 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 509193005891 dimer interface [polypeptide binding]; other site 509193005892 decamer (pentamer of dimers) interface [polypeptide binding]; other site 509193005893 catalytic triad [active] 509193005894 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 509193005895 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 509193005896 tetramer interface [polypeptide binding]; other site 509193005897 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193005898 catalytic residue [active] 509193005899 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 509193005900 Walker A/P-loop; other site 509193005901 ATP binding site [chemical binding]; other site 509193005902 Q-loop/lid; other site 509193005903 ABC transporter signature motif; other site 509193005904 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 509193005905 Sec1 family; Region: Sec1; pfam00995 509193005906 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193005907 Q-loop/lid; other site 509193005908 ABC transporter signature motif; other site 509193005909 Walker B; other site 509193005910 D-loop; other site 509193005911 H-loop/switch region; other site 509193005912 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 509193005913 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 509193005914 active site 509193005915 metal binding site [ion binding]; metal-binding site 509193005916 DNA binding site [nucleotide binding] 509193005917 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 509193005918 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 509193005919 UvrD/REP helicase; Region: UvrD-helicase; cl14126 509193005920 UvrD/REP helicase; Region: UvrD-helicase; cl14126 509193005921 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 509193005922 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 509193005923 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 509193005924 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 509193005925 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 509193005926 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 509193005927 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 509193005928 FtsX-like permease family; Region: FtsX; pfam02687 509193005929 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 509193005930 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 509193005931 Walker A/P-loop; other site 509193005932 ATP binding site [chemical binding]; other site 509193005933 Q-loop/lid; other site 509193005934 ABC transporter signature motif; other site 509193005935 Walker B; other site 509193005936 D-loop; other site 509193005937 H-loop/switch region; other site 509193005938 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 509193005939 E3 interaction surface; other site 509193005940 lipoyl attachment site [posttranslational modification]; other site 509193005941 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 509193005942 carboxyltransferase (CT) interaction site; other site 509193005943 biotinylation site [posttranslational modification]; other site 509193005944 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 509193005945 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 509193005946 MatE; Region: MatE; pfam01554 509193005947 MatE; Region: MatE; pfam01554 509193005948 DNA polymerase IV; Provisional; Region: PRK14133 509193005949 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 509193005950 active site 509193005951 DNA binding site [nucleotide binding] 509193005952 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 509193005953 nickel responsive regulator; Provisional; Region: PRK04460 509193005954 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 509193005955 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 509193005956 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 509193005957 cobalt transport protein CbiM; Provisional; Region: PRK07331 509193005958 Cobalt transport protein; Region: CbiQ; cl00463 509193005959 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 509193005960 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 509193005961 Walker A/P-loop; other site 509193005962 ATP binding site [chemical binding]; other site 509193005963 Q-loop/lid; other site 509193005964 ABC transporter signature motif; other site 509193005965 Walker B; other site 509193005966 D-loop; other site 509193005967 H-loop/switch region; other site 509193005968 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 509193005969 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 509193005970 G1 box; other site 509193005971 GTP/Mg2+ binding site [chemical binding]; other site 509193005972 Switch I region; other site 509193005973 G2 box; other site 509193005974 G3 box; other site 509193005975 Switch II region; other site 509193005976 G4 box; other site 509193005977 G5 box; other site 509193005978 Nucleoside recognition; Region: Gate; cl00486 509193005979 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 509193005980 Nucleoside recognition; Region: Gate; cl00486 509193005981 FeoA domain; Region: FeoA; cl00838 509193005982 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 509193005983 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193005984 aspartate aminotransferase; Provisional; Region: PRK08361 509193005985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 509193005986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193005987 homodimer interface [polypeptide binding]; other site 509193005988 catalytic residue [active] 509193005989 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 509193005990 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 509193005991 active site 509193005992 dimer interface [polypeptide binding]; other site 509193005993 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 509193005994 putative active site [active] 509193005995 Transposase, Mutator family; Region: Transposase_mut; pfam00872 509193005996 MULE transposase domain; Region: MULE; pfam10551 509193005997 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 509193005998 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 509193005999 ligand binding site [chemical binding]; other site 509193006000 dimerization interface [polypeptide binding]; other site 509193006001 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 509193006002 TM-ABC transporter signature motif; other site 509193006003 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 509193006004 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and...; Region: ABC_Carb_Monos_I; cd03216 509193006005 Walker A/P-loop; other site 509193006006 ATP binding site [chemical binding]; other site 509193006007 Q-loop/lid; other site 509193006008 ABC transporter signature motif; other site 509193006009 Walker B; other site 509193006010 D-loop; other site 509193006011 H-loop/switch region; other site 509193006012 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses (; Region: ABC_Carb_Monos_II; cd03215 509193006013 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 509193006014 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of...; Region: ribokinase; cd01174 509193006015 substrate binding site [chemical binding]; other site 509193006016 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 509193006017 dimer interface [polypeptide binding]; other site 509193006018 ATP binding site [chemical binding]; other site 509193006019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193006020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193006021 DNA binding site [nucleotide binding] 509193006022 domain linker motif; other site 509193006023 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 509193006024 dimerization interface [polypeptide binding]; other site 509193006025 ligand binding site [chemical binding]; other site 509193006026 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 509193006027 Integrase core domain; Region: rve; cl01316 509193006028 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 509193006029 Transposase; Region: DEDD_Tnp_IS110; pfam01548 509193006030 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 509193006031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 509193006032 Probable transposase; Region: OrfB_IS605; pfam01385 509193006033 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 509193006034 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 509193006035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193006036 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 509193006037 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193006038 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 509193006039 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 509193006040 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 509193006041 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 509193006042 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 509193006043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193006044 dimer interface [polypeptide binding]; other site 509193006045 conserved gate region; other site 509193006046 putative PBP binding loops; other site 509193006047 ABC-ATPase subunit interface; other site 509193006048 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 509193006049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193006050 dimer interface [polypeptide binding]; other site 509193006051 conserved gate region; other site 509193006052 putative PBP binding loops; other site 509193006053 ABC-ATPase subunit interface; other site 509193006054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 509193006055 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193006056 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193006057 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193006058 D-xylulose kinase; Region: XylB; TIGR01312 509193006059 FGGY family of carbohydrate kinases, C-terminal domain; Region: FGGY_C; pfam02782 509193006060 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 509193006061 xylose isomerase; Region: PLN02923 509193006062 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 509193006063 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006064 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 509193006065 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 509193006066 Cation transport protein; Region: TrkH; cl10514 509193006067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006068 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 509193006069 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 509193006070 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 509193006071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006072 Entner-Doudoroff aldolase; Region: eda; TIGR01182 509193006073 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509193006074 active site 509193006075 intersubunit interface [polypeptide binding]; other site 509193006076 catalytic residue [active] 509193006077 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 509193006078 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006079 Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four...; Region: PTS_IIB_man; cl00021 509193006080 active site 509193006081 phosphorylation site [posttranslational modification] 509193006082 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 509193006083 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 509193006084 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 509193006085 active pocket/dimerization site; other site 509193006086 active site 509193006087 phosphorylation site [posttranslational modification] 509193006088 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 509193006089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193006090 Walker A motif; other site 509193006091 ATP binding site [chemical binding]; other site 509193006092 Walker B motif; other site 509193006093 arginine finger; other site 509193006094 Transcriptional antiterminator [Transcription]; Region: COG3933 509193006095 PRD domain; Region: PRD; pfam00874 509193006096 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cl00025 509193006097 active pocket/dimerization site; other site 509193006098 active site 509193006099 phosphorylation site [posttranslational modification] 509193006100 PRD domain; Region: PRD; pfam00874 509193006101 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 509193006102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 509193006103 putative substrate translocation pore; other site 509193006104 Entner-Doudoroff aldolase; Region: eda; TIGR01182 509193006105 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 509193006106 active site 509193006107 intersubunit interface [polypeptide binding]; other site 509193006108 catalytic residue [active] 509193006109 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 509193006110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006111 galactonate dehydratase; Provisional; Region: PRK14017 509193006112 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 509193006113 putative active site pocket [active] 509193006114 putative metal binding site [ion binding]; other site 509193006115 SAF domain; Region: SAF; cl00555 509193006116 SAF domain; Region: SAF; cl00555 509193006117 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 509193006118 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006119 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 509193006120 P-loop; other site 509193006121 active site 509193006122 phosphorylation site [posttranslational modification] 509193006123 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509193006124 active site 509193006125 phosphorylation site [posttranslational modification] 509193006126 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 509193006127 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 509193006128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193006129 Walker A motif; other site 509193006130 ATP binding site [chemical binding]; other site 509193006131 Walker B motif; other site 509193006132 arginine finger; other site 509193006133 PRD domain; Region: PRD; pfam00874 509193006134 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 509193006135 active pocket/dimerization site; other site 509193006136 active site 509193006137 phosphorylation site [posttranslational modification] 509193006138 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 509193006139 active site 509193006140 phosphorylation site [posttranslational modification] 509193006141 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 509193006142 Phd_YefM; Region: PhdYeFM; cl09153 509193006143 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 509193006144 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 509193006145 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 509193006146 Uncharacterized conserved protein [Function unknown]; Region: COG2006 509193006147 4Fe-4S binding domain; Region: Fer4; cl02805 509193006148 integral membrane protein MviN; Region: mviN; TIGR01695 509193006149 Polysaccharide biosynthesis protein; Region: Polysacc_synt; cl10513 509193006150 MatE; Region: MatE; pfam01554 509193006151 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 509193006152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 509193006153 Probable transposase; Region: OrfB_IS605; pfam01385 509193006154 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 509193006155 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509193006156 DNA binding residues [nucleotide binding] 509193006157 Rod binding protein; Region: Rod-binding; cl01626 509193006158 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 509193006159 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 509193006160 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 509193006161 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 509193006162 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 509193006163 rod shape-determining protein Mbl; Provisional; Region: PRK13928 509193006164 Cell division protein FtsA; Region: FtsA; cl11496 509193006165 Stage III sporulation protein D; Region: SpoIIID; cl11824 509193006166 Peptidase family M23; Region: Peptidase_M23; pfam01551 509193006167 Stage II sporulation protein; Region: SpoIID; cl07201 509193006168 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 509193006169 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 509193006170 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 509193006171 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 509193006172 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222 509193006173 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006174 NAD(P) binding pocket [chemical binding]; other site 509193006175 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 509193006176 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 509193006177 hinge; other site 509193006178 active site 509193006179 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 509193006180 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 509193006181 catalytic motif [active] 509193006182 Zn binding site [ion binding]; other site 509193006183 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 509193006184 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 509193006185 Low molecular weight phosphatase family; Region: LMWPc; cd00115 509193006186 Active site [active] 509193006187 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 509193006188 SUA5 domain; Region: SUA5; pfam03481 509193006189 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 509193006190 peptide chain release factor 1; Validated; Region: prfA; PRK00591 509193006191 RF-1 domain; Region: RF-1; cl02875 509193006192 RF-1 domain; Region: RF-1; cl02875 509193006193 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 509193006194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193006195 S-adenosylmethionine binding site [chemical binding]; other site 509193006196 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 509193006197 Thymidine kinase; Region: TK; cl00631 509193006198 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 509193006199 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 509193006200 transcription termination factor Rho; Provisional; Region: rho; PRK09376 509193006201 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 509193006202 RNA binding site [nucleotide binding]; other site 509193006203 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 509193006204 multimer interface [polypeptide binding]; other site 509193006205 Walker A motif; other site 509193006206 ATP binding site [chemical binding]; other site 509193006207 Walker B motif; other site 509193006208 hypothetical protein; Provisional; Region: PRK08185 509193006209 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose...; Region: TBP_aldolase_IIB; cd00947 509193006210 intersubunit interface [polypeptide binding]; other site 509193006211 active site 509193006212 zinc binding site [ion binding]; other site 509193006213 Na+ binding site [ion binding]; other site 509193006214 Response regulator receiver domain; Region: Response_reg; pfam00072 509193006215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 509193006216 active site 509193006217 phosphorylation site [posttranslational modification] 509193006218 intermolecular recognition site; other site 509193006219 dimerization interface [polypeptide binding]; other site 509193006220 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 509193006221 trimer interface [polypeptide binding]; other site 509193006222 ferredoxin; Validated; Region: PRK07118 509193006223 Putative Fe-S cluster; Region: FeS; pfam04060 509193006224 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 509193006225 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 509193006226 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 509193006227 Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597 509193006228 FMN-binding domain; Region: FMN_bind; cl01081 509193006229 RnfE family; Region: NQR2_RnfD_RnfE; cl00779 509193006230 C subunit; Region: rnfC; TIGR01945 509193006231 The M14 family of metallocarboxypeptidases (MCPs) are zinc-binding carboxypeptidases (CPs) which hydrolyze single, C-terminal amino acids from polypeptide chains, and have a recognition site for the free C-terminal carboxyl group, which is a key...; Region: Peptidase_M14_like; cl11393 509193006232 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 509193006233 SLBB domain; Region: SLBB; pfam10531 509193006234 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 509193006235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193006236 Walker A motif; other site 509193006237 ATP binding site [chemical binding]; other site 509193006238 Walker B motif; other site 509193006239 arginine finger; other site 509193006240 Peptidase family M41; Region: Peptidase_M41; pfam01434 509193006241 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cl00252 509193006242 Domain of unknown function DUF59; Region: DUF59; cl00941 509193006243 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 509193006244 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 509193006245 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 509193006246 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 509193006247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193006248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 509193006249 Domain of unknown function (DUF348); Region: DUF348; pfam03990 509193006250 3D domain; Region: 3D; cl01439 509193006251 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 509193006252 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 509193006253 active site 509193006254 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 509193006255 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 509193006256 active site 509193006257 HIGH motif; other site 509193006258 KMSKS motif; other site 509193006259 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 509193006260 tRNA binding surface [nucleotide binding]; other site 509193006261 anticodon binding site; other site 509193006262 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 509193006263 dimer interface [polypeptide binding]; other site 509193006264 putative tRNA-binding site [nucleotide binding]; other site 509193006265 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 509193006266 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 509193006267 active site 509193006268 NTP binding site [chemical binding]; other site 509193006269 metal binding triad [ion binding]; metal-binding site 509193006270 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 509193006271 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 509193006272 Nucleoside recognition; Region: Gate; cl00486 509193006273 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 509193006274 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 509193006275 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 509193006276 Cation efflux family; Region: Cation_efflux; cl00316 509193006277 Predicted methyltransferases [General function prediction only]; Region: COG0313 509193006278 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 509193006279 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 509193006280 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 509193006281 S-adenosylmethionine binding site [chemical binding]; other site 509193006282 Arginine deiminase [Amino acid transport and metabolism]; Region: ArcA; COG2235 509193006283 Amidinotransferase; Region: Amidinotransf; cl12043 509193006284 PSP1 C-terminal conserved region; Region: PSP1; cl00770 509193006285 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 509193006286 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 509193006287 Protein of unknown function (DUF327); Region: DUF327; cl00753 509193006288 Nitrogen regulatory protein P-II; Region: P-II; cl00412 509193006289 thymidylate kinase; Validated; Region: tmk; PRK00698 509193006290 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 509193006291 TMP-binding site; other site 509193006292 ATP-binding site [chemical binding]; other site 509193006293 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 509193006294 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and...; Region: Orn_deC_like; cd00615 509193006295 homodimer interface [polypeptide binding]; other site 509193006296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 509193006297 catalytic residue [active] 509193006298 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 509193006299 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 509193006300 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 509193006301 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 509193006302 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 509193006303 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 509193006304 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193006305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193006306 putative inner membrane protein; Provisional; Region: PRK11099 509193006307 YeeE/YedE family (DUF395); Region: DUF395; cl01018 509193006308 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 509193006309 CPxP motif; other site 509193006310 putative inner membrane protein; Provisional; Region: PRK11099 509193006311 YeeE/YedE family (DUF395); Region: DUF395; cl01018 509193006312 Transcriptional regulator [Transcription]; Region: LysR; COG0583 509193006313 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193006314 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 509193006315 dimerization interface [polypeptide binding]; other site 509193006316 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 509193006317 CPxP motif; other site 509193006318 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 509193006319 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 509193006320 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 509193006321 Uncharacterized conserved protein [Function unknown]; Region: COG3535 509193006322 Protein of unknown function (DUF917); Region: DUF917; pfam06032 509193006323 Sodium:solute symporter family; Region: SSF; cl00456 509193006324 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 509193006325 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193006326 Walker A motif; other site 509193006327 ATP binding site [chemical binding]; other site 509193006328 Walker B motif; other site 509193006329 arginine finger; other site 509193006330 Protein of unknown function (DUF917); Region: DUF917; pfam06032 509193006331 Uracil DNA glycosylase superfamily; Region: UDG; cl00483 509193006332 Fumarase C-terminus; Region: Fumerase_C; cl00795 509193006333 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 509193006334 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 509193006335 Ligand Binding Site [chemical binding]; other site 509193006336 TIGR00269 family protein; Region: TIGR00269 509193006337 CD and pullulan-degrading enzymes N-terminus domain. Members of this subgroup include: Cyclomaltodextrinase (CDase), maltogenic amylase, and neopullulanase all of which are capable of hydrolyzing all or two of the following three types of substrates:...; Region: CD_pullulan_degrading_enzymes_N_term; cd02857 509193006338 homodimer; other site 509193006339 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 509193006340 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 509193006341 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 509193006342 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 509193006343 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 509193006344 Bacterial SH3 domain; Region: SH3_3; cl02551 509193006345 Bacterial SH3 domain; Region: SH3_3; cl02551 509193006346 Bacterial SH3 domain; Region: SH3_3; cl02551 509193006347 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 509193006348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006349 NAD(P) binding site [chemical binding]; other site 509193006350 active site 509193006351 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 509193006352 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193006353 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 509193006354 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 509193006355 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 509193006356 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 509193006357 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 509193006358 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 509193006359 active site 509193006360 Substrate binding site [chemical binding]; other site 509193006361 Mg++ binding site [ion binding]; other site 509193006362 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 509193006363 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 509193006364 sulfate 1 binding site; other site 509193006365 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 509193006366 active site 509193006367 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 509193006368 active site 509193006369 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 509193006370 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; cl14895 509193006371 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 509193006372 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 509193006373 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193006374 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 509193006375 Walker A/P-loop; other site 509193006376 ATP binding site [chemical binding]; other site 509193006377 Q-loop/lid; other site 509193006378 ABC transporter signature motif; other site 509193006379 Walker B; other site 509193006380 D-loop; other site 509193006381 H-loop/switch region; other site 509193006382 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193006383 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 509193006384 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 509193006385 Walker A/P-loop; other site 509193006386 ATP binding site [chemical binding]; other site 509193006387 Q-loop/lid; other site 509193006388 ABC transporter signature motif; other site 509193006389 Walker B; other site 509193006390 D-loop; other site 509193006391 H-loop/switch region; other site 509193006392 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 509193006393 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 509193006394 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 509193006395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193006396 dimer interface [polypeptide binding]; other site 509193006397 conserved gate region; other site 509193006398 putative PBP binding loops; other site 509193006399 ABC-ATPase subunit interface; other site 509193006400 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 509193006401 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 509193006402 dimer interface [polypeptide binding]; other site 509193006403 conserved gate region; other site 509193006404 putative PBP binding loops; other site 509193006405 ABC-ATPase subunit interface; other site 509193006406 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 509193006407 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 509193006408 substrate binding site [chemical binding]; other site 509193006409 Transcriptional regulators [Transcription]; Region: PurR; COG1609 509193006410 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 509193006411 DNA binding site [nucleotide binding] 509193006412 domain linker motif; other site 509193006413 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 509193006414 putative dimerization interface [polypeptide binding]; other site 509193006415 putative ligand binding site [chemical binding]; other site 509193006416 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 509193006417 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 509193006418 RNA binding surface [nucleotide binding]; other site 509193006419 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 509193006420 active site 509193006421 uracil binding [chemical binding]; other site 509193006422 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 509193006423 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 509193006424 NAD(P) binding site [chemical binding]; other site 509193006425 active site 509193006426 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193006427 Zn2+ binding site [ion binding]; other site 509193006428 Mg2+ binding site [ion binding]; other site 509193006429 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193006430 Zn2+ binding site [ion binding]; other site 509193006431 Mg2+ binding site [ion binding]; other site 509193006432 CrcB-like protein; Region: CRCB; cl09114 509193006433 CrcB-like protein; Region: CRCB; cl09114 509193006434 recombination protein RecR; Reviewed; Region: recR; PRK00076 509193006435 RecR protein; Region: RecR; pfam02132 509193006436 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 509193006437 putative active site [active] 509193006438 putative metal-binding site [ion binding]; other site 509193006439 tetramer interface [polypeptide binding]; other site 509193006440 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 509193006441 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 509193006442 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 509193006443 Walker A motif; other site 509193006444 ATP binding site [chemical binding]; other site 509193006445 Walker B motif; other site 509193006446 arginine finger; other site 509193006447 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 509193006448 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 509193006449 dimerization interface [polypeptide binding]; other site 509193006450 PAS domain S-box; Region: sensory_box; TIGR00229 509193006451 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 509193006452 putative active site [active] 509193006453 heme pocket [chemical binding]; other site 509193006454 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 509193006455 GAF domain; Region: GAF; cl00853 509193006456 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 509193006457 Zn2+ binding site [ion binding]; other site 509193006458 Mg2+ binding site [ion binding]; other site 509193006459 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 509193006460 nucleoside/Zn binding site; other site 509193006461 dimer interface [polypeptide binding]; other site 509193006462 catalytic motif [active] 509193006463 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 509193006464 active site 509193006465 catalytic triad [active] 509193006466 oxyanion hole [active] 509193006467 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 509193006468 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 509193006469 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 509193006470 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 509193006471 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 509193006472 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509193006473 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 509193006474 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 509193006475 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 509193006476 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 509193006477 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial...; Region: VirB11-like_ATPase; cd01130 509193006478 Walker A motif; other site 509193006479 hexamer interface [polypeptide binding]; other site 509193006480 ATP binding site [chemical binding]; other site 509193006481 Walker B motif; other site 509193006482 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 509193006483 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly...; Region: CpaE_like; cd03111 509193006484 SAF domain; Region: SAF; cl00555 509193006485 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 509193006486 Peptidase family M23; Region: Peptidase_M23; pfam01551 509193006487 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 509193006488 N-acetyl-D-glucosamine binding site [chemical binding]; other site 509193006489 catalytic residue [active] 509193006490 AAA-like domain; Region: AAA_10; pfam12846 509193006491 Domain of unknown function DUF87; Region: DUF87; pfam01935 509193006492 manganese transport regulator MntR; Provisional; Region: PRK11050 509193006493 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 509193006494 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl09100 509193006495 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 509193006496 non-specific DNA binding site [nucleotide binding]; other site 509193006497 salt bridge; other site 509193006498 sequence-specific DNA binding site [nucleotide binding]; other site 509193006499 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 509193006500 putative active site [active] 509193006501 catalytic site [active] 509193006502 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 509193006503 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 509193006504 Int/Topo IB signature motif; other site 509193006505 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 509193006506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 509193006507 adenylosuccinate synthetase; Provisional; Region: PRK01117 509193006508 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 509193006509 GDP-binding site [chemical binding]; other site 509193006510 ACT binding site; other site 509193006511 IMP binding site; other site 509193006512 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 509193006513 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193006514 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 509193006515 dimerization interface [polypeptide binding]; other site 509193006516 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 509193006517 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193006518 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 509193006519 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; cl14644 509193006520 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 509193006521 oligoendopeptidase F; Region: pepF; TIGR00181 509193006522 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 509193006523 active site 509193006524 Zn binding site [ion binding]; other site 509193006525 Chromate transporter; Region: Chromate_transp; pfam02417 509193006526 Chromate transporter; Region: Chromate_transp; pfam02417 509193006527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 509193006528 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 509193006529 Transposase; Region: DDE_Tnp_ISL3; pfam01610 509193006530 ATP synthase subunit D; Region: ATP-synt_D; cl00613 509193006531 V-type ATP synthase subunit B; Provisional; Region: PRK04196 509193006532 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509193006533 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the...; Region: V_A-ATPase_B; cd01135 509193006534 Walker A motif homologous position; other site 509193006535 Walker B motif; other site 509193006536 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509193006537 V-type ATP synthase subunit A; Provisional; Region: PRK04192 509193006538 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 509193006539 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 509193006540 Walker A motif/ATP binding site; other site 509193006541 Walker B motif; other site 509193006542 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 509193006543 ATP synthase (F/14-kDa) subunit; Region: ATP-synt_F; cl00632 509193006544 ATP synthase (C/AC39) subunit; Region: vATP-synt_AC39; cl00660 509193006545 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 509193006546 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 509193006547 V-type ATP synthase subunit K; Validated; Region: PRK06558 509193006548 ATP synthase subunit C; Region: ATP-synt_C; cl00466 509193006549 V-type ATP synthase subunit I; Validated; Region: PRK05771 509193006550 Hsp70 protein; Region: HSP70; pfam00012 509193006551 Sulfate transporter family; Region: Sulfate_transp; cl00967 509193006552 Permease family; Region: Xan_ur_permease; pfam00860 509193006553 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 509193006554 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 509193006555 ligand binding site [chemical binding]; other site 509193006556 flexible hinge region; other site 509193006557 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 509193006558 replicative DNA helicase; Region: DnaB; TIGR00665 509193006559 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 509193006560 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 509193006561 Walker A motif; other site 509193006562 ATP binding site [chemical binding]; other site 509193006563 Walker B motif; other site 509193006564 DNA binding loops [nucleotide binding] 509193006565 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 509193006566 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 509193006567 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 509193006568 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 509193006569 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 509193006570 DHH family; Region: DHH; pfam01368 509193006571 DHHA1 domain; Region: DHHA1; pfam02272 509193006572 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 509193006573 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 509193006574 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 509193006575 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 509193006576 dimer interface [polypeptide binding]; other site 509193006577 ssDNA binding site [nucleotide binding]; other site 509193006578 tetramer (dimer of dimers) interface [polypeptide binding]; other site 509193006579 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 509193006580 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 509193006581 Mechanosensitive ion channel; Region: MS_channel; pfam00924 509193006582 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 509193006583 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 509193006584 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193006585 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 509193006586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 509193006587 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 509193006588 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 509193006589 proposed catalytic triad [active] 509193006590 active site nucleophile [active] 509193006591 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 509193006592 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 509193006593 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 509193006594 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 509193006595 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 509193006596 catalytic residue [active] 509193006597 ParB-like partition proteins; Region: parB_part; TIGR00180 509193006598 ParB-like nuclease domain; Region: ParBc; cl02129 509193006599 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 509193006600 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 509193006601 P-loop; other site 509193006602 Magnesium ion binding site [ion binding]; other site 509193006603 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 509193006604 Magnesium ion binding site [ion binding]; other site 509193006605 ParB-like nuclease domain; Region: ParBc; cl02129 509193006606 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 509193006607 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cd02883 509193006608 nudix motif; other site 509193006609 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 509193006610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 509193006611 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; cl11520 509193006612 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 509193006613 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 509193006614 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 509193006615 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 509193006616 G1 box; other site 509193006617 GTP/Mg2+ binding site [chemical binding]; other site 509193006618 Switch I region; other site 509193006619 G2 box; other site 509193006620 Switch II region; other site 509193006621 G3 box; other site 509193006622 G4 box; other site 509193006623 G5 box; other site 509193006624 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 509193006625 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 509193006626 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 509193006627 G-X-X-G motif; other site 509193006628 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 509193006629 RxxxH motif; other site 509193006630 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 509193006631 Domain of unknown function DUF37; Region: DUF37; cl00506 509193006632 Ribonuclease P; Region: Ribonuclease_P; cl00457 509193006633 Ribosomal protein L34; Region: Ribosomal_L34; cl00370