-- dump date 20120504_163844 -- class Genbank::misc_feature -- table misc_feature_note -- id note 273068000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 273068000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068000003 Walker A motif; other site 273068000004 ATP binding site [chemical binding]; other site 273068000005 Walker B motif; other site 273068000006 arginine finger; other site 273068000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 273068000008 DnaA box-binding interface [nucleotide binding]; other site 273068000009 Pfam match to entry bac_dnaA, Bacterial dnaA protein, score 681.2, E-value 2.50E-229 273068000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 273068000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 273068000012 putative DNA binding surface [nucleotide binding]; other site 273068000013 dimer interface [polypeptide binding]; other site 273068000014 beta-clamp/clamp loader binding surface; other site 273068000015 beta-clamp/translesion DNA polymerase binding surface; other site 273068000016 Pfam match to entry DNA_pol3_beta, DNA polymerase III beta subunit, N-terminal domain, score 118.6, E-value 1.10E-31 273068000017 Pfam match to entry DNA_pol3_beta_2, DNA polymerase III beta subunit, central domain, score 102.7, E-value 1.20E-30 273068000018 Pfam match to entry DNA_pol3_beta_3, DNA polymerase III beta subunit, C-terminal domain, score 114.3, E-value 2.30E-30 273068000019 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273068000020 RNA binding surface [nucleotide binding]; other site 273068000021 recombination protein F; Reviewed; Region: recF; PRK00064 273068000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000023 Walker A/P-loop; other site 273068000024 ATP binding site [chemical binding]; other site 273068000025 Q-loop/lid; other site 273068000026 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000027 ABC transporter signature motif; other site 273068000028 Walker B; other site 273068000029 D-loop; other site 273068000030 H-loop/switch region; other site 273068000031 Pfam match to entry RecF, RecF protein, score 50.9, E-value 3.30E-13 273068000032 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 273068000033 trimer interface [polypeptide binding]; other site 273068000034 active site 273068000035 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 273068000036 catalytic site [active] 273068000037 Pfam match to entry Glyco_hydro_31, Glycosyl hydrolases family 31, score 636.7, E-value 1.30E-187 273068000038 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 273068000039 catalytic triad [active] 273068000040 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 273068000041 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 273068000042 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 273068000043 Pfam match to entry Mur_ligase, Mur ligase family, catalytic domain, score 74, E-value 5.90E-21 273068000044 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 273068000045 dimer interface [polypeptide binding]; other site 273068000046 putative tRNA-binding site [nucleotide binding]; other site 273068000047 Pfam match to entry tRNA_bind, Putative tRNA binding domain, score 102.8, E-value 6.80E-27 273068000048 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 273068000049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068000050 Mg2+ binding site [ion binding]; other site 273068000051 G-X-G motif; other site 273068000052 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 273068000053 anchoring element; other site 273068000054 dimer interface [polypeptide binding]; other site 273068000055 ATP binding site [chemical binding]; other site 273068000056 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 273068000057 active site 273068000058 putative metal-binding site [ion binding]; other site 273068000059 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 273068000060 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 95.6, E-value 4.50E-25 273068000061 Pfam match to entry DNA_topoisoII, DNA topoisomerase II (N-terminal region), score 348.3, E-value 8.20E-101 273068000062 Pfam match to entry Toprim, Toprim domain, score 55.2, E-value 1.50E-12 273068000063 Pfam match to entry DNA_gyraseB_C, DNA gyrase B subunit, carboxyl terminus, score 166.8, E-value 3.70E-46 273068000064 DNA gyrase subunit A; Validated; Region: PRK05560 273068000065 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 273068000066 CAP-like domain; other site 273068000067 active site 273068000068 primary dimer interface [polypeptide binding]; other site 273068000069 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273068000070 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273068000071 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273068000072 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273068000073 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273068000074 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 273068000075 Pfam match to entry DNA_topoisoIV, DNA gyrase/topoisomerase IV, subunit A, score 1043.9, E-value 0 273068000076 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 273068000077 active site 273068000078 FMN binding site [chemical binding]; other site 273068000079 substrate binding site [chemical binding]; other site 273068000080 homotetramer interface [polypeptide binding]; other site 273068000081 catalytic residue [active] 273068000082 Pfam match to entry oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase family, score 403.1, E-value 2.60E-117 273068000083 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068000084 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068000085 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068000086 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068000087 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 273068000088 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 273068000089 putative valine binding site [chemical binding]; other site 273068000090 dimer interface [polypeptide binding]; other site 273068000091 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 273068000092 Pfam match to entry ACT, ACT domain, score 66.3, E-value 6.60E-16 273068000093 ketol-acid reductoisomerase; Provisional; Region: PRK05479 273068000094 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000095 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 273068000096 Pfam match to entry IlvC, Acetohydroxy acid isomeroreductase, catalytic domain, score 314.3, E-value 1.40E-90 273068000097 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 273068000098 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 273068000099 active site 273068000100 catalytic residues [active] 273068000101 metal binding site [ion binding]; metal-binding site 273068000102 Pfam match to entry HMGL-like, HMGL-like, score 416.2, E-value 3.00E-121 273068000103 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 273068000104 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 273068000105 substrate binding site [chemical binding]; other site 273068000106 ligand binding site [chemical binding]; other site 273068000107 Pfam match to entry aconitase, Aconitase family (aconitate hydratase), score 260.3, E-value 6.80E-79 273068000108 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 273068000109 substrate binding site [chemical binding]; other site 273068000110 Pfam match to entry Aconitase_C, Aconitase C-terminal domain, score 59.8, E-value 5.90E-14 273068000111 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 273068000112 tartrate dehydrogenase; Provisional; Region: PRK08194 273068000113 Pfam match to entry isodh, Isocitrate and isopropylmalate dehydrogenases, score 712.4, E-value 2.20E-212 273068000114 Dehydratase family; Region: ILVD_EDD; cl00340 273068000115 Pfam match to entry ILVD_EDD, Dehydratase family, score 967.4, E-value 3.70E-287 273068000116 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 273068000117 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 273068000118 PYR/PP interface [polypeptide binding]; other site 273068000119 dimer interface [polypeptide binding]; other site 273068000120 TPP binding site [chemical binding]; other site 273068000121 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 273068000122 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 273068000123 TPP-binding site [chemical binding]; other site 273068000124 dimer interface [polypeptide binding]; other site 273068000125 Pfam match to entry TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain, score 332.7, E-value 4.20E-96 273068000126 Pfam match to entry TPP_enzymes, Thiamine pyrophosphate enzyme, central domain, score 200.4, E-value 2.80E-56 273068000127 Pfam match to entry TPP_enzymes_C, Thiamine pyrophosphate enzyme, C-terminal TPP binding domain, score 269.7, E-value 3.90E-77 273068000128 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; cl00465 273068000129 Domain of unknown function DUF20; Region: UPF0118; pfam01594 273068000130 Pfam match to entry UPF0118, Domain of unknown function DUF20, score 181.1, E-value 1.80E-50 273068000131 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 273068000132 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 273068000133 Catalytic site [active] 273068000134 Pfam match to entry Peptidase_S26, Signal peptidase I, score 118.9, E-value 1.70E-35 273068000135 seryl-tRNA synthetase; Provisional; Region: PRK05431 273068000136 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 273068000137 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 273068000138 dimer interface [polypeptide binding]; other site 273068000139 active site 273068000140 motif 1; other site 273068000141 motif 2; other site 273068000142 motif 3; other site 273068000143 Pfam match to entry Seryl_tRNA_N, Seryl-tRNA synthetase N-terminal domain, score 54.2, E-value 2.80E-12 273068000144 Pfam match to entry tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 375.8, E-value 4.30E-109 273068000145 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 273068000146 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 273068000147 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 273068000148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273068000149 Integrase core domain; Region: rve; cl01316 273068000150 Pfam match to entry rve, Integrase core domain, score 23.9, E-value 9.70E-06 273068000151 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 273068000152 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 273068000153 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273068000154 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 273068000155 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068000156 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 273068000157 Pfam match to entry Cation_ATPase_N, Cation transporter/ATPase, N-terminus, score 64.4, E-value 2.40E-15 273068000158 Pfam match to entry E1-E2_ATPase, E1-E2 ATPase, score 383.9, E-value 1.70E-115 273068000159 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 83, E-value 6.30E-21 273068000160 Pfam match to entry Cation_ATPase_C, Cation transporting ATPase, C-terminus, score 90.5, E-value 3.40E-23 273068000161 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 273068000162 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 273068000163 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000164 Walker A/P-loop; other site 273068000165 ATP binding site [chemical binding]; other site 273068000166 Q-loop/lid; other site 273068000167 ABC transporter signature motif; other site 273068000168 Walker B; other site 273068000169 D-loop; other site 273068000170 H-loop/switch region; other site 273068000171 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068000172 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 273068000173 active site 273068000174 catalytic triad [active] 273068000175 oxyanion hole [active] 273068000176 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 273068000177 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 273068000178 nucleoside/Zn binding site; other site 273068000179 dimer interface [polypeptide binding]; other site 273068000180 catalytic motif [active] 273068000181 Pfam match to entry dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 171.1, E-value 1.80E-47 273068000182 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068000183 dimerization interface [polypeptide binding]; other site 273068000184 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 273068000185 PAS domain S-box; Region: sensory_box; TIGR00229 273068000186 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273068000187 putative active site [active] 273068000188 heme pocket [chemical binding]; other site 273068000189 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 273068000190 GAF domain; Region: GAF; cl00853 273068000191 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068000192 Zn2+ binding site [ion binding]; other site 273068000193 Mg2+ binding site [ion binding]; other site 273068000194 Pfam match to entry HAMP, HAMP domain, score 42.7, E-value 8.40E-09 273068000195 Pfam match to entry PAS, PAS domain, score 37.6, E-value 8.10E-09 273068000196 Pfam match to entry GAF, GAF domain, score 38.3, E-value 1.70E-07 273068000197 Pfam match to entry HD, HD domain, score 70, E-value 5.00E-17 273068000198 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 273068000199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068000200 Walker A motif; other site 273068000201 ATP binding site [chemical binding]; other site 273068000202 Walker B motif; other site 273068000203 arginine finger; other site 273068000204 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 273068000205 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 43.7, E-value 4.10E-09 273068000206 YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494 273068000207 Pfam match to entry DUF149, Uncharacterized BCR, YbaB family COG0718, score 118.8, E-value 1.10E-31 273068000208 recombination protein RecR; Reviewed; Region: recR; PRK00076 273068000209 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 273068000210 RecR protein; Region: RecR; pfam02132 273068000211 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 273068000212 putative active site [active] 273068000213 putative metal-binding site [ion binding]; other site 273068000214 tetramer interface [polypeptide binding]; other site 273068000215 Pfam match to entry RecR, RecR protein, score 63.8, E-value 3.60E-15 273068000216 Pfam match to entry Toprim, Toprim domain, score 78.6, E-value 1.30E-19 273068000217 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068000218 Zn2+ binding site [ion binding]; other site 273068000219 Mg2+ binding site [ion binding]; other site 273068000220 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068000221 Zn2+ binding site [ion binding]; other site 273068000222 Mg2+ binding site [ion binding]; other site 273068000223 Pfam match to entry HD, HD domain, score 56.8, E-value 4.80E-13 273068000224 Pfam match to entry HD, HD domain, score 63.7, E-value 3.80E-15 273068000225 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 273068000226 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000227 NAD(P) binding site [chemical binding]; other site 273068000228 active site 273068000229 Pfam match to entry adh_short, short chain dehydrogenase, score 231.9, E-value 9.10E-66 273068000230 Pfam match to entry adh_short_C2, Short chain dehydrogenase/reductase C-terminus, score 45.2, E-value 3.60E-11 273068000231 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 273068000232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273068000233 RNA binding surface [nucleotide binding]; other site 273068000234 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 273068000235 active site 273068000236 uracil binding [chemical binding]; other site 273068000237 Pfam match to entry PseudoU_synth_2, RNA pseudouridylate synthase, score 65.6, E-value 1.10E-15 273068000238 Pfam match to entry S4, S4 domain, score 42, E-value 1.40E-08 273068000239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273068000240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068000241 DNA binding site [nucleotide binding] 273068000242 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 273068000243 putative dimerization interface [polypeptide binding]; other site 273068000244 putative ligand binding site [chemical binding]; other site 273068000245 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 32.7, E-value 2.00E-06 273068000246 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 273068000247 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273068000248 substrate binding site [chemical binding]; other site 273068000249 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 38.6, E-value 5.70E-10 273068000250 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273068000251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068000252 dimer interface [polypeptide binding]; other site 273068000253 conserved gate region; other site 273068000254 putative PBP binding loops; other site 273068000255 ABC-ATPase subunit interface; other site 273068000256 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068000257 dimer interface [polypeptide binding]; other site 273068000258 conserved gate region; other site 273068000259 putative PBP binding loops; other site 273068000260 ABC-ATPase subunit interface; other site 273068000261 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273068000262 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068000263 Walker A/P-loop; other site 273068000264 ATP binding site [chemical binding]; other site 273068000265 Q-loop/lid; other site 273068000266 ABC transporter signature motif; other site 273068000267 Walker B; other site 273068000268 D-loop; other site 273068000269 H-loop/switch region; other site 273068000270 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068000271 Pfam match to entry ABC_tran, ABC transporter, score 178.6, E-value 1.00E-49 273068000272 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 273068000273 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068000274 Walker A/P-loop; other site 273068000275 ATP binding site [chemical binding]; other site 273068000276 Q-loop/lid; other site 273068000277 ABC transporter signature motif; other site 273068000278 Walker B; other site 273068000279 D-loop; other site 273068000280 H-loop/switch region; other site 273068000281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068000282 Pfam match to entry ABC_tran, ABC transporter, score 162.5, E-value 7.00E-45 273068000283 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 273068000284 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 273068000285 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 273068000286 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 273068000287 active site 273068000288 Domain of unknown function (DUF377); Region: DUF377; pfam04041 273068000289 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 273068000290 active site 273068000291 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 273068000292 Pfam match to entry Form_Nir_trans, Formate/nitrite transporter, score 264, E-value 2.00E-75 273068000293 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 273068000294 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 273068000295 active site 273068000296 Substrate binding site; other site 273068000297 Mg++ binding site; other site 273068000298 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 273068000299 Pfam match to entry NTP_transferase, Nucleotidyl transferase, score 204.6, E-value 1.50E-57 273068000300 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 273068000301 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 273068000302 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 61.9, E-value 5.50E-16 273068000303 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 273068000304 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 273068000305 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 273068000306 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 273068000307 Pfam match to entry Dala_Dala_ligas, D-ala D-ala ligase, score 72.5, E-value 6.10E-19 273068000308 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 273068000309 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000310 NAD(P) binding site [chemical binding]; other site 273068000311 active site 273068000312 Pfam match to entry adh_short, short chain dehydrogenase, score 252, E-value 8.20E-72 273068000313 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273068000314 Helix-turn-helix domains; Region: HTH; cl00088 273068000315 Pfam match to entry tetR, Bacterial regulatory proteins, tetR family, score 75.8, E-value 8.80E-19 273068000316 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068000317 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068000318 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 273068000319 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 273068000320 Ligand Binding Site [chemical binding]; other site 273068000321 TIGR00269 family protein; Region: TIGR00269 273068000322 Pfam match to entry UPF0021, Uncharacterized protein family UPF0021, score 237.5, E-value 1.90E-67 273068000323 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 273068000324 Fumarase C-terminus; Region: Fumerase_C; cl00795 273068000325 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 273068000326 Fe-S cluster binding site [ion binding]; other site 273068000327 active site 273068000328 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 273068000329 CPxP motif; other site 273068000330 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 273068000331 Helix-turn-helix domains; Region: HTH; cl00088 273068000332 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068000333 dimerization interface [polypeptide binding]; other site 273068000334 Pfam match to entry HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 131.5, E-value 1.50E-35 273068000335 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 273068000336 CPxP motif; other site 273068000337 Pfam match to entry UPF0033, Uncharacterized protein family UPF0033, score 73.5, E-value 4.40E-18 273068000338 putative inner membrane protein; Provisional; Region: PRK11099 273068000339 Sulphur transport; Region: Sulf_transp; cl01018 273068000340 Sulphur transport; Region: Sulf_transp; cl01018 273068000341 DsrE/DsrF-like family; Region: DrsE; cl00672 273068000342 Pfam match to entry DrsE, DsrE-like protein, score 78.1, E-value 1.90E-19 273068000343 DsrE/DsrF-like family; Region: DrsE; cl00672 273068000344 DsrE/DsrF-like family; Region: DrsE; cl00672 273068000345 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 273068000346 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000347 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273068000348 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 317.9, E-value 1.20E-91 273068000349 Pfam match to entry pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 152.1, E-value 9.50E-42 273068000350 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 273068000351 lipoyl attachment site [posttranslational modification]; other site 273068000352 Pfam match to entry GCV_H, Glycine cleavage H-protein, score 194.9, E-value 1.20E-54 273068000353 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273068000354 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068000355 Pfam match to entry ROK, ROK family, score 229.2, E-value 4.50E-67 273068000356 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 273068000357 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 273068000358 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 273068000359 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 273068000360 homodimer interface [polypeptide binding]; other site 273068000361 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068000362 catalytic residue [active] 273068000363 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 273068000364 Pfam match to entry OKR_DC_1, Orn/Lys/Arg decarboxylase, score 402.6, E-value 3.80E-117 273068000365 thymidylate kinase; Validated; Region: tmk; PRK00698 273068000366 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 273068000367 TMP-binding site; other site 273068000368 ATP-binding site [chemical binding]; other site 273068000369 Pfam match to entry Thymidylate_kin, Thymidylate kinase, score 231.8, E-value 9.80E-66 273068000370 Nitrogen regulatory protein P-II; Region: P-II; cl00412 273068000371 Protein of unknown function (DUF327); Region: DUF327; cl00753 273068000372 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 273068000373 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000374 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 273068000375 PSP1 C-terminal conserved region; Region: PSP1; cl00770 273068000376 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 273068000377 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 273068000378 Pfam match to entry DUF81, Domain of unknown function DUF81, score 89.5, E-value 2.00E-24 273068000379 Pfam match to entry DUF81, Domain of unknown function DUF81, score 42.2, E-value 6.90E-11 273068000380 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 273068000381 Sulfatase; Region: Sulfatase; cl10460 273068000382 Amidinotransferase; Region: Amidinotransf; cl12043 273068000383 Pfam match to entry Arg_deiminase, Arginine deiminase, score 347, E-value 2.10E-100 273068000384 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 273068000385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068000386 S-adenosylmethionine binding site [chemical binding]; other site 273068000387 Predicted methyltransferases [General function prediction only]; Region: COG0313 273068000388 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 273068000389 Pfam match to entry TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases., score 176, E-value 6.00E-49 273068000390 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 273068000391 Cation efflux family; Region: Cation_efflux; cl00316 273068000392 Pfam match to entry Cation_efflux, Cation efflux family, score 289.1, E-value 5.40E-83 273068000393 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 273068000394 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 273068000395 Nucleoside recognition; Region: Gate; cl00486 273068000396 Nucleoside recognition; Region: Gate; cl00486 273068000397 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 273068000398 active site 273068000399 NTP binding site [chemical binding]; other site 273068000400 metal binding triad [ion binding]; metal-binding site 273068000401 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 273068000402 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068000403 Pfam match to entry PolyA_pol, Poly A polymerase family, score 154.8, E-value 1.50E-42 273068000404 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 273068000405 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 273068000406 active site 273068000407 HIGH motif; other site 273068000408 KMSKS motif; other site 273068000409 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 273068000410 tRNA binding surface [nucleotide binding]; other site 273068000411 anticodon binding site; other site 273068000412 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 273068000413 dimer interface [polypeptide binding]; other site 273068000414 putative tRNA-binding site [nucleotide binding]; other site 273068000415 Pfam match to entry tRNA-synt_1, 'tRNA synthetases class I (I, L, M and V)', score -108, E-value 5.10E-11 273068000416 Pfam match to entry tRNA_bind, Putative tRNA binding domain, score 138, E-value 1.70E-37 273068000417 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 273068000418 active site 273068000419 Pfam match to entry TatD_DNase, TatD related DNase, score 362.9, E-value 3.40E-105 273068000420 Domain of unknown function (DUF348); Region: DUF348; pfam03990 273068000421 Domain of unknown function (DUF348); Region: DUF348; pfam03990 273068000422 G5 domain; Region: G5; pfam07501 273068000423 3D domain; Region: 3D; cl01439 273068000424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068000425 S-adenosylmethionine binding site [chemical binding]; other site 273068000426 Pfam match to entry RrnaAD, Ribosomal RNA adenine dimethylases, score 249.7, E-value 6.00E-77 273068000427 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 273068000428 S-layer homology domain; Region: SLH; pfam00395 273068000429 S-layer homology domain; Region: SLH; pfam00395 273068000430 Pfam match to entry SLH, S-layer homology domain, score 43.2, E-value 5.80E-09 273068000431 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 273068000432 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 273068000433 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068000434 Domain of unknown function DUF59; Region: DUF59; cl00941 273068000435 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 273068000436 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 273068000437 Pfam match to entry DUF59, Domain of unknown function DUF59, score 93.4, E-value 4.60E-24 273068000438 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 273068000439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068000440 Walker A motif; other site 273068000441 ATP binding site [chemical binding]; other site 273068000442 Walker B motif; other site 273068000443 arginine finger; other site 273068000444 Peptidase family M41; Region: Peptidase_M41; pfam01434 273068000445 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 286.6, E-value 3.20E-82 273068000446 Pfam match to entry Peptidase_M41, Peptidase family M41, score 97.8, E-value 2.20E-25 273068000447 NADH:ubiquinone oxidoreductase subunit 2 (chain N) [Energy production and conversion]; Region: NuoN; COG1007 273068000448 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 273068000449 Pfam match to entry oxidored_q1_N, NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus, score 33.2, E-value 3.60E-07 273068000450 Pfam match to entry oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 255.5, E-value 7.10E-73 273068000451 NADH dehydrogenase; Region: NADHdh; cl00469 273068000452 Pfam match to entry NADHdh, NADH dehydrogenase, score 48.8, E-value 1.20E-12 273068000453 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 273068000454 Pfam match to entry oxidored_q6, NADH ubiquinone oxidoreductase, 20 Kd subunit, score 185.1, E-value 1.10E-51 273068000455 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 273068000456 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 273068000457 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 273068000458 Pfam match to entry NiFeSe_Hases, Nickel-dependent hydrogenase, score 29.7, E-value 1.30E-08 273068000459 Pfam match to entry complex1_49Kd, Respiratory-chain NADH dehydrogenase, 49 Kd subunit, score 125.9, E-value 3.60E-45 273068000460 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273068000461 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273068000462 Pfam match to entry fer4, 4Fe-4S binding domain, score 28.3, E-value 9.80E-05 273068000463 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; cl00418 273068000464 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 273068000465 Pfam match to entry HypA, Hydrogenase expression/synthesis hypA family, score 95.9, E-value 7.80E-25 273068000466 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000467 Pfam match to entry HypB_UreG, HypB/UreG nucleotide-binding domain, score 165.7, E-value 7.60E-46 273068000468 Acylphosphatase; Region: Acylphosphatase; cl00551 273068000469 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 273068000470 HypF finger; Region: zf-HYPF; pfam07503 273068000471 HypF finger; Region: zf-HYPF; pfam07503 273068000472 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 273068000473 Pfam match to entry Sua5_yciO_yrdC, Sua5/yciO/yrdC family, score 242.4, E-value 6.30E-69 273068000474 HupF/HypC family; Region: HupF_HypC; cl00394 273068000475 Pfam match to entry HupF_HypC, HupF/HypC family, score 77.8, E-value 2.30E-19 273068000476 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 273068000477 Hydrogenase formation hypA family; Region: HypD; cl12072 273068000478 Pfam match to entry HypD, Hydrogenase formation hypA family, score 583.2, E-value 1.60E-171 273068000479 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 273068000480 dimerization interface [polypeptide binding]; other site 273068000481 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 273068000482 ATP binding site [chemical binding]; other site 273068000483 Pfam match to entry AIRS, AIR synthase related protein, N-terminal domain, score 151.8, E-value 1.20E-41 273068000484 Pfam match to entry AIRS_C, AIR synthase related protein, C-terminal domain, score 144, E-value 1.60E-39 273068000485 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 273068000486 Response regulator receiver domain; Region: Response_reg; pfam00072 273068000487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068000488 active site 273068000489 phosphorylation site [posttranslational modification] 273068000490 intermolecular recognition site; other site 273068000491 dimerization interface [polypeptide binding]; other site 273068000492 hypothetical protein; Provisional; Region: PRK08185 273068000493 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 273068000494 intersubunit interface [polypeptide binding]; other site 273068000495 active site 273068000496 zinc binding site [ion binding]; other site 273068000497 Na+ binding site [ion binding]; other site 273068000498 Pfam match to entry F_bP_aldolase, Fructose-bisphosphate aldolase class-II, score 444.8, E-value 7.30E-130 273068000499 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 273068000500 transcription termination factor Rho; Provisional; Region: rho; PRK09376 273068000501 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 273068000502 RNA binding site [nucleotide binding]; other site 273068000503 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 273068000504 multimer interface [polypeptide binding]; other site 273068000505 Walker A motif; other site 273068000506 ATP binding site [chemical binding]; other site 273068000507 Walker B motif; other site 273068000508 Pfam match to entry ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 239.2, E-value 5.80E-68 273068000509 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 273068000510 Pfam match to entry Ribosomal_L31, Ribosomal protein L31, score 154.1, E-value 2.40E-42 273068000511 thymidine kinase; Provisional; Region: PRK04296 273068000512 Pfam match to entry TK, Thymidine kinase, score 274.6, E-value 1.50E-95 273068000513 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 273068000514 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 273068000515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 273068000516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068000517 peptide chain release factor 1; Validated; Region: prfA; PRK00591 273068000518 RF-1 domain; Region: RF-1; cl02875 273068000519 RF-1 domain; Region: RF-1; cl02875 273068000520 Pfam match to entry RF-1, Peptidyl-tRNA hydrolase domain, score 265.8, E-value 5.70E-76 273068000521 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 273068000522 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 273068000523 SUA5 domain; Region: SUA5; pfam03481 273068000524 Pfam match to entry Sua5_yciO_yrdC, Sua5/yciO/yrdC family, score 234.3, E-value 1.70E-66 273068000525 Low molecular weight phosphatase family; Region: LMWPc; cd00115 273068000526 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 273068000527 active site 273068000528 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 273068000529 Pfam match to entry LMWPc, Low molecular weight phosphotyrosine protein phosphatase, score 143, E-value 5.30E-39 273068000530 Pfam match to entry LacAB_rpiB, Ribose/Galactose Isomerase, score 177.3, E-value 2.50E-49 273068000531 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068000532 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 52.1, E-value 1.20E-11 273068000533 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 273068000534 catalytic motif [active] 273068000535 Zn binding site [ion binding]; other site 273068000536 Pfam match to entry dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 144.3, E-value 2.10E-39 273068000537 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068000538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068000539 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068000540 Pfam match to entry Transposase_9, Transposase, score 52.6, E-value 8.50E-12 273068000541 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 87.4, E-value 3.00E-22 273068000542 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 273068000543 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 273068000544 Mg++ binding site [ion binding]; other site 273068000545 putative catalytic motif [active] 273068000546 substrate binding site [chemical binding]; other site 273068000547 Pfam match to entry Glycos_transf_4, Glycosyl transferase, score 193.4, E-value 3.50E-54 273068000548 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 273068000549 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 273068000550 active site 273068000551 homodimer interface [polypeptide binding]; other site 273068000552 Pfam match to entry Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 599.2, E-value 2.60E-176 273068000553 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 273068000554 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 273068000555 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 273068000556 hinge; other site 273068000557 active site 273068000558 Pfam match to entry EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 515.3, E-value 4.50E-151 273068000559 OPT oligopeptide transporter protein; Region: OPT; cl14607 273068000560 oligopeptide transporters, OPT superfamily; Region: OPT_sfam; TIGR00728 273068000561 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 273068000562 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 273068000563 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 273068000564 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000565 NAD(P) binding pocket [chemical binding]; other site 273068000566 Pfam match to entry AlaDh_PNT, Alanine dehydrogenase/pyridine nucleotide transhydrogenase, score 701.9, E-value 3.00E-207 273068000567 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 273068000568 catalytic nucleophile [active] 273068000569 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068000570 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068000571 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 273068000572 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 273068000573 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 273068000574 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 273068000575 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 273068000576 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 273068000577 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 273068000578 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 273068000579 IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the...; Region: IPT_PCSR; cd00603 273068000580 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 273068000581 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 273068000582 Pfam match to entry TIG, IPT/TIG domain, score 47.7, E-value 2.50E-10 273068000583 Pfam match to entry TIG, IPT/TIG domain, score 50.9, E-value 2.80E-11 273068000584 Pfam match to entry TIG, IPT/TIG domain, score 60.4, E-value 4.00E-14 273068000585 Pfam match to entry TIG, IPT/TIG domain, score 42.9, E-value 7.40E-09 273068000586 Pfam match to entry TIG, IPT/TIG domain, score 46.5, E-value 6.00E-10 273068000587 Pfam match to entry TIG, IPT/TIG domain, score 50.1, E-value 5.00E-11 273068000588 Pfam match to entry TIG, IPT/TIG domain, score 62.6, E-value 8.60E-15 273068000589 Pfam match to entry fn3, Fibronectin type III domain, score 32.9, E-value 7.40E-06 273068000590 S-layer homology domain; Region: SLH; pfam00395 273068000591 S-layer homology domain; Region: SLH; pfam00395 273068000592 Pfam match to entry SLH, S-layer homology domain, score 53.5, E-value 4.60E-12 273068000593 S-layer homology domain; Region: SLH; pfam00395 273068000594 S-layer homology domain; Region: SLH; pfam00395 273068000595 Pfam match to entry SLH, S-layer homology domain, score 38.6, E-value 1.50E-07 273068000596 Pfam match to entry SLH, S-layer homology domain, score 28.5, E-value 0.00015 273068000597 stage II sporulation protein D; Region: spore_II_D; TIGR02870 273068000598 Stage II sporulation protein; Region: SpoIID; pfam08486 273068000599 Peptidase family M23; Region: Peptidase_M23; pfam01551 273068000600 Pfam match to entry Peptidase_M37, Peptidase family M23/M37, score 83.7, E-value 3.80E-21 273068000601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 273068000602 rod shape-determining protein Mbl; Provisional; Region: PRK13928 273068000603 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 273068000604 ATP binding site [chemical binding]; other site 273068000605 profilin binding site; other site 273068000606 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 273068000607 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 273068000608 Pfam match to entry flg_bb_rod, Flagella basal body rod protein, score 48.8, E-value 4.30E-11 273068000609 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 273068000610 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 273068000611 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 273068000612 Pfam match to entry flg_bb_rod, Flagella basal body rod protein, score 48.4, E-value 5.80E-11 273068000613 Rod binding protein; Region: Rod-binding; cl01626 273068000614 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 273068000615 Pfam match to entry Thioester_dehyd, Thioester dehydrase, score 210.6, E-value 2.30E-59 273068000616 integral membrane protein MviN; Region: mviN; TIGR01695 273068000617 MatE; Region: MatE; cl10513 273068000618 MatE; Region: MatE; cl10513 273068000619 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 273068000620 Uncharacterized conserved protein [Function unknown]; Region: COG2006 273068000621 4Fe-4S binding domain; Region: Fer4; cl02805 273068000622 Pfam match to entry fer4, 4Fe-4S binding domain, score 34, E-value 3.50E-06 273068000623 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 273068000624 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 273068000625 Pfam match to entry DUF152, Uncharacterized ACR, YfiH family COG1496, score 197.3, E-value 2.50E-55 273068000626 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 273068000627 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 273068000628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068000629 Walker A motif; other site 273068000630 ATP binding site [chemical binding]; other site 273068000631 Walker B motif; other site 273068000632 arginine finger; other site 273068000633 PRD domain; Region: PRD; cl15445 273068000634 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 273068000635 active pocket/dimerization site; other site 273068000636 active site 273068000637 phosphorylation site [posttranslational modification] 273068000638 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273068000639 active site 273068000640 phosphorylation site [posttranslational modification] 273068000641 Pfam match to entry sigma54, Sigma-54 interaction domain, score 85.6, E-value 8.20E-23 273068000642 Pfam match to entry BglG_antitermin, Transcriptional antiterminator bglG family, score 71.8, E-value 1.50E-17 273068000643 Pfam match to entry PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 53.9, E-value 3.60E-12 273068000644 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273068000645 active site 273068000646 phosphorylation site [posttranslational modification] 273068000647 Pfam match to entry PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 77.3, E-value 3.10E-19 273068000648 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 273068000649 P-loop; other site 273068000650 active site 273068000651 phosphorylation site [posttranslational modification] 273068000652 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 273068000653 Helix-turn-helix domains; Region: HTH; cl00088 273068000654 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 273068000655 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273068000656 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 273068000657 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 273068000658 substrate binding site [chemical binding]; other site 273068000659 hexamer interface [polypeptide binding]; other site 273068000660 metal binding site [ion binding]; metal-binding site 273068000661 Pfam match to entry Ribul_P_3_epim, Ribulose-phosphate 3 epimerase family, score 219.1, E-value 6.50E-62 273068000662 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 273068000663 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 273068000664 tetramer interface [polypeptide binding]; other site 273068000665 TPP-binding site [chemical binding]; other site 273068000666 heterodimer interface [polypeptide binding]; other site 273068000667 phosphorylation loop region [posttranslational modification] 273068000668 Pfam match to entry E1_dehydrog, Dehydrogenase E1 component, score 489.4, E-value 2.70E-143 273068000669 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 273068000670 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 273068000671 alpha subunit interface [polypeptide binding]; other site 273068000672 TPP binding site [chemical binding]; other site 273068000673 heterodimer interface [polypeptide binding]; other site 273068000674 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273068000675 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 273068000676 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273068000677 E3 interaction surface; other site 273068000678 lipoyl attachment site [posttranslational modification]; other site 273068000679 e3 binding domain; Region: E3_binding; pfam02817 273068000680 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 273068000681 Pfam match to entry biotin_lipoyl, Biotin-requiring enzyme, score 81.5, E-value 1.70E-20 273068000682 Pfam match to entry e3_binding, e3 binding domain, score 71.1, E-value 2.30E-17 273068000683 Pfam match to entry 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain), score 337.5, E-value 1.50E-97 273068000684 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 273068000685 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 273068000686 TPP-binding site [chemical binding]; other site 273068000687 dimer interface [polypeptide binding]; other site 273068000688 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 273068000689 PYR/PP interface [polypeptide binding]; other site 273068000690 dimer interface [polypeptide binding]; other site 273068000691 TPP binding site [chemical binding]; other site 273068000692 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273068000693 Pfam match to entry transketolase, Transketolase, thiamine diphosphate binding domain, score 703.5, E-value 1.00E-207 273068000694 Pfam match to entry transketolaseD2, Transketolase, central domain, score 367.1, E-value 1.90E-106 273068000695 Pfam match to entry transketolaseD3, Transketolase, C-terminal domain, score 178.5, E-value 1.10E-49 273068000696 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 273068000697 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068000698 Walker A motif; other site 273068000699 ATP binding site [chemical binding]; other site 273068000700 Walker B motif; other site 273068000701 arginine finger; other site 273068000702 Transcriptional antiterminator [Transcription]; Region: COG3933 273068000703 PRD domain; Region: PRD; cl15445 273068000704 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 273068000705 active pocket/dimerization site; other site 273068000706 active site 273068000707 phosphorylation site [posttranslational modification] 273068000708 PRD domain; Region: PRD; cl15445 273068000709 Pfam match to entry sigma54, Sigma-54 interaction domain, score 65.8, E-value 2.80E-17 273068000710 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 273068000711 active pocket/dimerization site; other site 273068000712 active site 273068000713 phosphorylation site [posttranslational modification] 273068000714 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 273068000715 active site 273068000716 phosphorylation site [posttranslational modification] 273068000717 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 273068000718 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 273068000719 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000720 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 273068000721 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 273068000722 Pfam match to entry 6PGD, 6-phosphogluconate dehydrogenase, score 704.5, E-value 5.10E-208 273068000723 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 273068000724 Cation transport protein; Region: TrkH; cl10514 273068000725 Pfam match to entry TrkH, Sodium transport protein, score 470.7, E-value 1.20E-137 273068000726 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 273068000727 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000728 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 273068000729 Pfam match to entry KTN, KTN NAD-binding domain, score 180.6, E-value 2.60E-50 273068000730 Pfam match to entry TrkA, Potassium channel, score 55.1, E-value 1.50E-12 273068000731 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 273068000732 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273068000733 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068000734 Pfam match to entry GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 73.7, E-value 3.70E-18 273068000735 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 273068000736 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 273068000737 putative active site [active] 273068000738 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000739 Pfam match to entry PhoH, PhoH-like protein, score -90.6, E-value 4.30E-08 273068000740 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273068000741 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068000742 DNA binding site [nucleotide binding] 273068000743 domain linker motif; other site 273068000744 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273068000745 dimerization interface [polypeptide binding]; other site 273068000746 ligand binding site [chemical binding]; other site 273068000747 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 54.2, E-value 5.60E-14 273068000748 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 123, E-value 5.40E-33 273068000749 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273068000750 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 273068000751 substrate binding site [chemical binding]; other site 273068000752 dimer interface [polypeptide binding]; other site 273068000753 ATP binding site [chemical binding]; other site 273068000754 Pfam match to entry pfkB, pfkB family carbohydrate kinase, score 299.2, E-value 5.10E-86 273068000755 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 273068000756 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273068000757 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 273068000758 Walker A/P-loop; other site 273068000759 ATP binding site [chemical binding]; other site 273068000760 Q-loop/lid; other site 273068000761 ABC transporter signature motif; other site 273068000762 Walker B; other site 273068000763 D-loop; other site 273068000764 H-loop/switch region; other site 273068000765 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 273068000766 Pfam match to entry ABC_tran, ABC transporter, score 212.2, E-value 8.00E-60 273068000767 Pfam match to entry ABC_tran, ABC transporter, score 120.6, E-value 2.80E-32 273068000768 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273068000769 TM-ABC transporter signature motif; other site 273068000770 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 273068000771 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 273068000772 ligand binding site [chemical binding]; other site 273068000773 dimerization interface [polypeptide binding]; other site 273068000774 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 44, E-value 3.40E-09 273068000775 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 273068000776 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273068000777 peptide binding site [polypeptide binding]; other site 273068000778 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 422.6, E-value 3.70E-123 273068000779 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 273068000780 Pfam match to entry Asp_Glu_race, Asp/Glu/Hydontoin racemase, score 230.7, E-value 2.10E-65 273068000781 diaminopimelate decarboxylase; Region: lysA; TIGR01048 273068000782 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 273068000783 active site 273068000784 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273068000785 substrate binding site [chemical binding]; other site 273068000786 catalytic residues [active] 273068000787 dimer interface [polypeptide binding]; other site 273068000788 Pfam match to entry Orn_Arg_deC_N, Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 258.4, E-value 1.40E-75 273068000789 Pfam match to entry Orn_Dap_Arg_deC, Pyridoxal-dependent decarboxylase, C-terminal sheet domain, score 137.2, E-value 1.30E-37 273068000790 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273068000791 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273068000792 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273068000793 putative active site [active] 273068000794 Pfam match to entry HTH_6, Helix-turn-helix domain, rpiR family, score 118.2, E-value 1.60E-31 273068000795 Pfam match to entry SIS, SIS domain, score 101.1, E-value 2.20E-26 273068000796 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 273068000797 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 273068000798 putative active site [active] 273068000799 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068000800 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 273068000801 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 273068000802 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 273068000803 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 273068000804 Pfam match to entry Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain, score 304.8, E-value 1.00E-87 273068000805 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 273068000806 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068000807 Uncharacterised protein family (UPF0075); Region: UPF0075; cl04217 273068000808 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 273068000809 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273068000810 Coenzyme A binding pocket [chemical binding]; other site 273068000811 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 273068000812 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 46.1, E-value 7.90E-10 273068000813 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 36.6, E-value 5.60E-07 273068000814 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 273068000815 Pfam match to entry DUF158, Uncharacterized LmbE-like protein, COG2120, score 38.9, E-value 8.20E-09 273068000816 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273068000817 Coenzyme A binding pocket [chemical binding]; other site 273068000818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273068000819 Coenzyme A binding pocket [chemical binding]; other site 273068000820 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 37.2, E-value 3.80E-07 273068000821 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 57.1, E-value 3.80E-13 273068000822 FAD binding domain; Region: FAD_binding_4; pfam01565 273068000823 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 273068000824 Pfam match to entry FAD_binding_4, FAD binding domain, score 267.7, E-value 1.60E-76 273068000825 Pfam match to entry FAD-oxidase_C, FAD linked oxidases, C-terminal domain, score 212, E-value 9.20E-60 273068000826 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273068000827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068000828 dimer interface [polypeptide binding]; other site 273068000829 conserved gate region; other site 273068000830 putative PBP binding loops; other site 273068000831 ABC-ATPase subunit interface; other site 273068000832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273068000833 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273068000834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068000835 dimer interface [polypeptide binding]; other site 273068000836 conserved gate region; other site 273068000837 putative PBP binding loops; other site 273068000838 ABC-ATPase subunit interface; other site 273068000839 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 42, E-value 1.40E-08 273068000840 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273068000841 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068000842 Walker A/P-loop; other site 273068000843 ATP binding site [chemical binding]; other site 273068000844 Q-loop/lid; other site 273068000845 ABC transporter signature motif; other site 273068000846 Walker B; other site 273068000847 D-loop; other site 273068000848 H-loop/switch region; other site 273068000849 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068000850 Pfam match to entry ABC_tran, ABC transporter, score 174, E-value 2.40E-48 273068000851 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273068000852 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068000853 Walker A/P-loop; other site 273068000854 ATP binding site [chemical binding]; other site 273068000855 Q-loop/lid; other site 273068000856 ABC transporter signature motif; other site 273068000857 Walker B; other site 273068000858 D-loop; other site 273068000859 H-loop/switch region; other site 273068000860 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068000861 Pfam match to entry ABC_tran, ABC transporter, score 183.3, E-value 3.90E-51 273068000862 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 273068000863 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273068000864 substrate binding site [chemical binding]; other site 273068000865 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 36, E-value 3.00E-09 273068000866 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 273068000867 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 273068000868 active site 273068000869 dimer interface [polypeptide binding]; other site 273068000870 Pfam match to entry NagA, N-acetylglucosamine-6-phosphate deacetylase, score 238.2, E-value 1.10E-67 273068000871 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068000872 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068000873 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068000874 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 77.6, E-value 2.60E-19 273068000875 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068000876 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068000877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068000878 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068000879 Pfam match to entry Transposase_9, Transposase, score 52.6, E-value 8.50E-12 273068000880 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 87.4, E-value 3.00E-22 273068000881 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 273068000882 active site 273068000883 Glyco_18 domain; Region: Glyco_18; smart00636 273068000884 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 273068000885 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 273068000886 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 273068000887 Pfam match to entry Glyco_hydro_3, Glycosyl hydrolase family 3 N terminal domain, score 321.5, E-value 9.70E-93 273068000888 FeoA domain; Region: FeoA; cl00838 273068000889 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 273068000890 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 273068000891 G1 box; other site 273068000892 GTP/Mg2+ binding site [chemical binding]; other site 273068000893 Switch I region; other site 273068000894 G2 box; other site 273068000895 G3 box; other site 273068000896 Switch II region; other site 273068000897 G4 box; other site 273068000898 G5 box; other site 273068000899 Nucleoside recognition; Region: Gate; cl00486 273068000900 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 273068000901 Nucleoside recognition; Region: Gate; cl00486 273068000902 Pfam match to entry FeoB, Ferrous iron transport protein B, score 650.1, E-value 1.20E-191 273068000903 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068000904 active site 273068000905 NTP binding site [chemical binding]; other site 273068000906 metal binding triad [ion binding]; metal-binding site 273068000907 antibiotic binding site [chemical binding]; other site 273068000908 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 273068000909 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 273068000910 Walker A/P-loop; other site 273068000911 ATP binding site [chemical binding]; other site 273068000912 Q-loop/lid; other site 273068000913 ABC transporter signature motif; other site 273068000914 Walker B; other site 273068000915 D-loop; other site 273068000916 H-loop/switch region; other site 273068000917 Pfam match to entry ABC_tran, ABC transporter, score 204.5, E-value 1.60E-57 273068000918 Cobalt transport protein; Region: CbiQ; cl00463 273068000919 Pfam match to entry CbiQ, Cobalt transport protein, score 95.4, E-value 1.10E-24 273068000920 PDGLE domain; Region: PDGLE; cl07986 273068000921 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 273068000922 Pfam match to entry CbiM, CbiM, score 171, E-value 2.00E-47 273068000923 nickel responsive regulator; Provisional; Region: PRK04460 273068000924 Uncharacterised protein family (UPF0156); Region: RHH_2; cl01448 273068000925 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 273068000926 Peptidase propeptide and YPEB domain; Region: PepSY; cl15815 273068000927 subunit; Region: OAD_beta; cl00816 273068000928 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 273068000929 Pfam match to entry SpoU_methylase, SpoU rRNA Methylase family, score 154.1, E-value 2.50E-42 273068000930 DNA polymerase IV; Provisional; Region: PRK14133 273068000931 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 273068000932 active site 273068000933 DNA binding site [nucleotide binding] 273068000934 Pfam match to entry IMS, impB/mucB/samB family, score 397.1, E-value 1.70E-115 273068000935 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 273068000936 MatE; Region: MatE; cl10513 273068000937 MatE; Region: MatE; cl10513 273068000938 Pfam match to entry UPF0013, Uncharacterized membrane protein family UPF0013, score 135.5, E-value 9.70E-37 273068000939 Pfam match to entry UPF0013, Uncharacterized membrane protein family UPF0013, score 144.1, E-value 2.40E-39 273068000940 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273068000941 E3 interaction surface; other site 273068000942 lipoyl attachment site [posttranslational modification]; other site 273068000943 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 273068000944 carboxyltransferase (CT) interaction site; other site 273068000945 biotinylation site [posttranslational modification]; other site 273068000946 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 273068000947 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273068000948 E3 interaction surface; other site 273068000949 lipoyl attachment site [posttranslational modification]; other site 273068000950 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273068000951 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 273068000952 Walker A/P-loop; other site 273068000953 ATP binding site [chemical binding]; other site 273068000954 Q-loop/lid; other site 273068000955 ABC transporter signature motif; other site 273068000956 Walker B; other site 273068000957 D-loop; other site 273068000958 H-loop/switch region; other site 273068000959 Pfam match to entry ABC_tran, ABC transporter, score 202.2, E-value 8.10E-57 273068000960 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 273068000961 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273068000962 FtsX-like permease family; Region: FtsX; pfam02687 273068000963 Pfam match to entry DUF214, Predicted permease, score 196.8, E-value 3.40E-55 273068000964 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cd00522 273068000965 octamerization interface [polypeptide binding]; other site 273068000966 diferric-oxygen binding site [ion binding]; other site 273068000967 Pfam match to entry Hemerythrin, Hemerythrin, score 101.6, E-value 1.60E-26 273068000968 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 273068000969 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 273068000970 Pfam match to entry FAA_hydrolase, Fumarylacetoacetate (FAA) hydrolase family, score 325.1, E-value 8.00E-94 273068000971 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 273068000972 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 273068000973 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 273068000974 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 273068000975 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 273068000976 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 273068000977 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 273068000978 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000979 Family description; Region: UvrD_C_2; cl15862 273068000980 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 273068000981 Pfam match to entry UvrD-helicase, UvrD/REP helicase, score 364, E-value 1.50E-105 273068000982 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 273068000983 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 273068000984 active site 273068000985 metal binding site [ion binding]; metal-binding site 273068000986 DNA binding site [nucleotide binding] 273068000987 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 273068000988 Pfam match to entry DNA_repair, DNA repair exonuclease, score 224.6, E-value 1.40E-63 273068000989 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 273068000990 Walker A/P-loop; other site 273068000991 ATP binding site [chemical binding]; other site 273068000992 Q-loop/lid; other site 273068000993 ABC transporter signature motif; other site 273068000994 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 273068000995 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068000996 Q-loop/lid; other site 273068000997 ABC transporter signature motif; other site 273068000998 Walker B; other site 273068000999 D-loop; other site 273068001000 H-loop/switch region; other site 273068001001 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 273068001002 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 273068001003 tetramer interface [polypeptide binding]; other site 273068001004 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068001005 catalytic residue [active] 273068001006 GAF domain; Region: GAF_2; pfam13185 273068001007 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 273068001008 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068001009 Walker A motif; other site 273068001010 ATP binding site [chemical binding]; other site 273068001011 Walker B motif; other site 273068001012 arginine finger; other site 273068001013 Helix-turn-helix domains; Region: HTH; cl00088 273068001014 Pfam match to entry sigma54, Sigma-54 interaction domain, score 432, E-value 5.40E-126 273068001015 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 273068001016 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 273068001017 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 273068001018 putative peroxiredoxin; Provisional; Region: PRK13599 273068001019 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 273068001020 dimer interface [polypeptide binding]; other site 273068001021 decamer (pentamer of dimers) interface [polypeptide binding]; other site 273068001022 catalytic triad [active] 273068001023 Pfam match to entry AhpC-TSA, AhpC/TSA family, score 167.8, E-value 1.90E-46 273068001024 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273068001025 metal binding site 2 [ion binding]; metal-binding site 273068001026 putative DNA binding helix; other site 273068001027 metal binding site 1 [ion binding]; metal-binding site 273068001028 dimer interface [polypeptide binding]; other site 273068001029 structural Zn2+ binding site [ion binding]; other site 273068001030 Pfam match to entry FUR, Ferric uptake regulator family, score 95.1, E-value 1.40E-24 273068001031 Helix-turn-helix domains; Region: HTH; cl00088 273068001032 ADP-glucose phosphorylase; Region: PLN02643 273068001033 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 273068001034 nucleotide binding site/active site [active] 273068001035 HIT family signature motif; other site 273068001036 catalytic residue [active] 273068001037 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 273068001038 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 273068001039 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 273068001040 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 180.6, E-value 2.50E-50 273068001041 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 273068001042 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 273068001043 Pfam match to entry DedA, DedA family, score 41.2, E-value 2.40E-08 273068001044 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 273068001045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 273068001046 Flagellar FliJ protein; Region: FliJ; cl09161 273068001047 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 273068001048 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 273068001049 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 273068001050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273068001051 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 273068001052 Domain of unknown function (DUF296); Region: DUF296; cl00720 273068001053 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 273068001054 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 273068001055 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 273068001056 Pfam match to entry DUF100, Protein of unknown function DUF100, score 742.2, E-value 2.30E-219 273068001057 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 273068001058 ligand binding site [chemical binding]; other site 273068001059 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 273068001060 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068001061 dimerization interface [polypeptide binding]; other site 273068001062 Histidine kinase; Region: His_kinase; pfam06580 273068001063 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068001064 ATP binding site [chemical binding]; other site 273068001065 Mg2+ binding site [ion binding]; other site 273068001066 G-X-G motif; other site 273068001067 Pfam match to entry HAMP, HAMP domain, score 42.4, E-value 9.90E-09 273068001068 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 35.9, E-value 1.50E-08 273068001069 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 273068001070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068001071 active site 273068001072 phosphorylation site [posttranslational modification] 273068001073 intermolecular recognition site; other site 273068001074 dimerization interface [polypeptide binding]; other site 273068001075 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273068001076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273068001077 Pfam match to entry response_reg, Response regulator receiver domain, score 127.2, E-value 3.00E-34 273068001078 Pfam match to entry HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 114.1, E-value 2.70E-30 273068001079 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 273068001080 putative ligand binding site [chemical binding]; other site 273068001081 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 273068001082 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 273068001083 putative ligand binding site [chemical binding]; other site 273068001084 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 273068001085 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 273068001086 Walker A/P-loop; other site 273068001087 ATP binding site [chemical binding]; other site 273068001088 Q-loop/lid; other site 273068001089 ABC transporter signature motif; other site 273068001090 Walker B; other site 273068001091 D-loop; other site 273068001092 H-loop/switch region; other site 273068001093 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 273068001094 Pfam match to entry ABC_tran, ABC transporter, score 194.9, E-value 1.30E-54 273068001095 Pfam match to entry ABC_tran, ABC transporter, score 89.5, E-value 6.70E-23 273068001096 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273068001097 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273068001098 TM-ABC transporter signature motif; other site 273068001099 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 273068001100 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 273068001101 tetramer interface [polypeptide binding]; other site 273068001102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068001103 catalytic residue [active] 273068001104 Pfam match to entry GDC-P, Glycine cleavage system P-protein, score -230.4, E-value 7.30E-06 273068001105 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 273068001106 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 273068001107 tetramer interface [polypeptide binding]; other site 273068001108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068001109 catalytic residue [active] 273068001110 Pfam match to entry GDC-P, Glycine cleavage system P-protein, score 648, E-value 5.00E-191 273068001111 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 273068001112 lipoyl attachment site [posttranslational modification]; other site 273068001113 Pfam match to entry GCV_H, Glycine cleavage H-protein, score 201.6, E-value 1.20E-56 273068001114 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 273068001115 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 273068001116 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 273068001117 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 273068001118 Pfam match to entry GCV_T, Glycine cleavage T-protein (aminomethyl transferase), score 558.5, E-value 4.40E-164 273068001119 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 273068001120 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 273068001121 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 273068001122 Pfam match to entry Lipoate_A, Lipoate-protein ligase A, score 247.7, E-value 1.60E-70 273068001123 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068001124 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 273068001125 Pfam match to entry CMD, Carboxymuconolactone decarboxylase, score 112.2, E-value 9.80E-30 273068001126 OsmC-like protein; Region: OsmC; cl00767 273068001127 hypothetical protein; Validated; Region: PRK07682 273068001128 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273068001129 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068001130 homodimer interface [polypeptide binding]; other site 273068001131 catalytic residue [active] 273068001132 Pfam match to entry aminotran_1, Aminotransferase class-I, score 255.6, E-value 6.80E-73 273068001133 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 273068001134 Helix-turn-helix domains; Region: HTH; cl00088 273068001135 Helix-turn-helix domains; Region: HTH; cl00088 273068001136 PRD domain; Region: PRD; cl15445 273068001137 PRD domain; Region: PRD; cl15445 273068001138 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 273068001139 P-loop; other site 273068001140 active site 273068001141 phosphorylation site [posttranslational modification] 273068001142 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273068001143 active site 273068001144 phosphorylation site [posttranslational modification] 273068001145 Pfam match to entry BglG_antitermin, Transcriptional antiterminator bglG family, score 63.3, E-value 5.10E-15 273068001146 Pfam match to entry BglG_antitermin, Transcriptional antiterminator bglG family, score 44.8, E-value 1.90E-09 273068001147 Pfam match to entry PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 186.5, E-value 4.30E-52 273068001148 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 273068001149 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 273068001150 P-loop; other site 273068001151 active site 273068001152 phosphorylation site [posttranslational modification] 273068001153 hypothetical protein; Provisional; Region: PRK02947 273068001154 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273068001155 putative active site [active] 273068001156 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 273068001157 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068001158 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068001159 Pfam match to entry Transposase_9, Transposase, score 52.6, E-value 8.50E-12 273068001160 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 77.9, E-value 2.10E-19 273068001161 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 273068001162 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 273068001163 dimer interface [polypeptide binding]; other site 273068001164 active site 273068001165 metal binding site [ion binding]; metal-binding site 273068001166 Pfam match to entry Fe-ADH, Iron-containing alcohol dehydrogenase, score 284.1, E-value 1.80E-81 273068001167 Transglycosylase; Region: Transgly; cl07896 273068001168 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 273068001169 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068001170 Pfam match to entry Transglycosyl, Transglycosylase, score 266.5, E-value 3.60E-76 273068001171 Pfam match to entry Transpeptidase, Penicillin binding protein transpeptidase domain, score 98.4, E-value 1.50E-25 273068001172 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 273068001173 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 273068001174 metal binding site [ion binding]; metal-binding site 273068001175 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273068001176 Helix-turn-helix domains; Region: HTH; cl00088 273068001177 Pfam match to entry tetR, Bacterial regulatory proteins, tetR family, score 54.3, E-value 1.80E-12 273068001178 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; pfam09989 273068001179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 273068001180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 273068001181 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; pfam09989 273068001182 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068001183 Pfam match to entry BcrAD_BadFG, BadF/BadG/BcrA/BcrD ATPase family, score 218.1, E-value 1.30E-61 273068001184 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 273068001185 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 273068001186 Walker A/P-loop; other site 273068001187 ATP binding site [chemical binding]; other site 273068001188 Q-loop/lid; other site 273068001189 ABC transporter signature motif; other site 273068001190 Walker B; other site 273068001191 D-loop; other site 273068001192 H-loop/switch region; other site 273068001193 Pfam match to entry ABC_tran, ABC transporter, score 219.2, E-value 6.10E-62 273068001194 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 273068001195 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 273068001196 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 273068001197 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068001198 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 273068001199 Pfam match to entry Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 35.5, E-value 1.20E-06 273068001200 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 273068001201 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 273068001202 HIGH motif; other site 273068001203 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273068001204 active site 273068001205 KMSKS motif; other site 273068001206 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 273068001207 tRNA binding surface [nucleotide binding]; other site 273068001208 Pfam match to entry tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 516.3, E-value 2.20E-151 273068001209 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068001210 active site 273068001211 NTP binding site [chemical binding]; other site 273068001212 metal binding triad [ion binding]; metal-binding site 273068001213 antibiotic binding site [chemical binding]; other site 273068001214 Pfam match to entry NTP_transf_2, Nucleotidyltransferase domain, score 49.6, E-value 6.90E-11 273068001215 putative kinase; Provisional; Region: PRK09954 273068001216 Helix-turn-helix domains; Region: HTH; cl00088 273068001217 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 273068001218 substrate binding site [chemical binding]; other site 273068001219 ATP binding site [chemical binding]; other site 273068001220 Pfam match to entry pfkB, pfkB family carbohydrate kinase, score 230.3, E-value 2.80E-65 273068001221 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 273068001222 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 273068001223 Phosphate transporter family; Region: PHO4; cl00396 273068001224 Pfam match to entry PHO4, Phosphate transporter family, score 157.4, E-value 1.00E-49 273068001225 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 273068001226 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 273068001227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068001228 Walker B motif; other site 273068001229 arginine finger; other site 273068001230 Transcriptional antiterminator [Transcription]; Region: COG3933 273068001231 PRD domain; Region: PRD; cl15445 273068001232 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 273068001233 active pocket/dimerization site; other site 273068001234 active site 273068001235 phosphorylation site [posttranslational modification] 273068001236 PRD domain; Region: PRD; cl15445 273068001237 Pfam match to entry sigma54, Sigma-54 interaction domain, score 95.2, E-value 1.70E-25 273068001238 Pfam match to entry BglG_antitermin, Transcriptional antiterminator bglG family, score 84.8, E-value 1.70E-21 273068001239 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 273068001240 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 273068001241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068001242 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068001243 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068001244 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068001245 YdjC-like protein; Region: YdjC; cl01344 273068001246 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 273068001247 active site 273068001248 P-loop; other site 273068001249 phosphorylation site [posttranslational modification] 273068001250 Pfam match to entry PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 110.2, E-value 4.00E-29 273068001251 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 273068001252 methionine cluster; other site 273068001253 active site 273068001254 phosphorylation site [posttranslational modification] 273068001255 metal binding site [ion binding]; metal-binding site 273068001256 Pfam match to entry PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit, score 170.6, E-value 2.60E-47 273068001257 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 273068001258 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 273068001259 NAD binding site [chemical binding]; other site 273068001260 sugar binding site [chemical binding]; other site 273068001261 divalent metal binding site [ion binding]; other site 273068001262 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273068001263 dimer interface [polypeptide binding]; other site 273068001264 Pfam match to entry Glyco_hydro_4, Family 4 glycosyl hydrolase, score 579.8, E-value 1.70E-170 273068001265 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 273068001266 Pfam match to entry Glyco_hydro_1, Glycosyl hydrolase family 1, score 571.1, E-value 7.10E-168 273068001267 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 273068001268 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 273068001269 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 273068001270 active site 273068001271 P-loop; other site 273068001272 phosphorylation site [posttranslational modification] 273068001273 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 273068001274 PRD domain; Region: PRD; cl15445 273068001275 PRD domain; Region: PRD; cl15445 273068001276 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 273068001277 P-loop; other site 273068001278 active site 273068001279 phosphorylation site [posttranslational modification] 273068001280 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 273068001281 Pfam match to entry BglG_antitermin, Transcriptional antiterminator bglG family, score 63.7, E-value 4.00E-15 273068001282 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273068001283 active site 273068001284 phosphorylation site [posttranslational modification] 273068001285 Pfam match to entry PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 196.7, E-value 3.70E-55 273068001286 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 273068001287 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 273068001288 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 273068001289 Pfam match to entry Mannitol_dh, Mannitol dehydrogenase, score 469.7, E-value 2.40E-137 273068001290 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 273068001291 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 273068001292 active site 273068001293 metal binding site [ion binding]; metal-binding site 273068001294 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 273068001295 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 273068001296 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 273068001297 active site 273068001298 metal binding site [ion binding]; metal-binding site 273068001299 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 273068001300 Bacterial SH3 domain; Region: SH3_3; cl02551 273068001301 Bacterial SH3 domain; Region: SH3_3; cl02551 273068001302 Pfam match to entry 5_nucleotidase, 5'-nucleotidase, catalytic domain, score 225.1, E-value 4.10E-65 273068001303 Pfam match to entry 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score 143.9, E-value 2.80E-39 273068001304 Pfam match to entry 5_nucleotidase, 5'-nucleotidase, catalytic domain, score 274.5, E-value 1.30E-79 273068001305 Pfam match to entry 5_nucleotidaseC, 5'-nucleotidase, C-terminal domain, score 114.4, E-value 2.20E-30 273068001306 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 273068001307 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 273068001308 FMN binding site [chemical binding]; other site 273068001309 active site 273068001310 catalytic residues [active] 273068001311 substrate binding site [chemical binding]; other site 273068001312 Pfam match to entry UPF0034, Uncharacterized protein family UPF0034, score 442, E-value 5.30E-129 273068001313 Uncharacterized ArCR, COG2043; Region: DUF169; cl00894 273068001314 Pfam match to entry DUF169, Uncharacterized ArCR, COG2043, score 96, E-value 7.50E-25 273068001315 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 273068001316 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273068001317 Pfam match to entry fer4, 4Fe-4S binding domain, score 33.1, E-value 6.60E-06 273068001318 Pfam match to entry fer4, 4Fe-4S binding domain, score 34.1, E-value 3.20E-06 273068001319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068001320 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068001321 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068001322 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068001323 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 273068001324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273068001325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068001326 DNA binding site [nucleotide binding] 273068001327 domain linker motif; other site 273068001328 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273068001329 dimerization interface [polypeptide binding]; other site 273068001330 ligand binding site [chemical binding]; other site 273068001331 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 35.5, E-value 1.60E-08 273068001332 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 91.8, E-value 1.30E-23 273068001333 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 273068001334 substrate binding site [chemical binding]; other site 273068001335 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273068001336 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 88.1, E-value 8.90E-24 273068001337 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273068001338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068001339 dimer interface [polypeptide binding]; other site 273068001340 conserved gate region; other site 273068001341 putative PBP binding loops; other site 273068001342 ABC-ATPase subunit interface; other site 273068001343 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273068001344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068001345 putative PBP binding loops; other site 273068001346 ABC-ATPase subunit interface; other site 273068001347 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 34.9, E-value 1.80E-06 273068001348 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273068001349 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068001350 Walker A/P-loop; other site 273068001351 ATP binding site [chemical binding]; other site 273068001352 Q-loop/lid; other site 273068001353 ABC transporter signature motif; other site 273068001354 Walker B; other site 273068001355 D-loop; other site 273068001356 H-loop/switch region; other site 273068001357 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068001358 Pfam match to entry ABC_tran, ABC transporter, score 125.3, E-value 1.10E-33 273068001359 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 273068001360 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068001361 Walker A/P-loop; other site 273068001362 ATP binding site [chemical binding]; other site 273068001363 Q-loop/lid; other site 273068001364 ABC transporter signature motif; other site 273068001365 Walker B; other site 273068001366 D-loop; other site 273068001367 H-loop/switch region; other site 273068001368 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068001369 Pfam match to entry ABC_tran, ABC transporter, score 158.4, E-value 1.30E-43 273068001370 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068001371 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068001372 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068001373 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068001374 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 273068001375 Pfam match to entry Glyco_hydro_1, Glycosyl hydrolase family 1, score 793.5, E-value 8.00E-235 273068001376 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 273068001377 Carbohydrate binding domain (family 17/28); Region: CBM_17_28; pfam03424 273068001378 Pfam match to entry cellulase, Cellulase (glycosyl hydrolase family 5), score 333.7, E-value 2.10E-96 273068001379 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 273068001380 substrate binding site [chemical binding]; other site 273068001381 metal binding site [ion binding]; metal-binding site 273068001382 dimer interface [polypeptide binding]; other site 273068001383 Pfam match to entry Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 30.1, E-value 2.00E-07 273068001384 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273068001385 dimer interface [polypeptide binding]; other site 273068001386 putative PBP binding regions; other site 273068001387 ABC-ATPase subunit interface; other site 273068001388 Pfam match to entry ABC-3, ABC 3 transport family, score 295.4, E-value 7.20E-85 273068001389 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 273068001390 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 273068001391 Pfam match to entry ABC_tran, ABC transporter, score 188.2, E-value 1.30E-52 273068001392 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 273068001393 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 273068001394 metal binding site [ion binding]; metal-binding site 273068001395 Pfam match to entry Lipoprotein_4, Periplasmic solute binding protein family, score 303.7, E-value 2.20E-87 273068001396 ferric uptake regulator; Provisional; Region: fur; PRK09462 273068001397 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273068001398 metal binding site 2 [ion binding]; metal-binding site 273068001399 putative DNA binding helix; other site 273068001400 metal binding site 1 [ion binding]; metal-binding site 273068001401 dimer interface [polypeptide binding]; other site 273068001402 structural Zn2+ binding site [ion binding]; other site 273068001403 Pfam match to entry FUR, Ferric uptake regulator family, score 102.8, E-value 6.60E-27 273068001404 MoxR-like ATPases [General function prediction only]; Region: COG0714 273068001405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068001406 Walker A motif; other site 273068001407 ATP binding site [chemical binding]; other site 273068001408 Walker B motif; other site 273068001409 arginine finger; other site 273068001410 Pfam match to entry Mg_chelatase, Magnesium chelatase, subunit ChlI, score 20.2, E-value 1.10E-09 273068001411 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 273068001412 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 273068001413 Pfam match to entry DUF58, Protein of unknown function DUF58, score 73, E-value 6.20E-18 273068001414 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 273068001415 homodimer interface [polypeptide binding]; other site 273068001416 Walker A motif; other site 273068001417 ATP binding site [chemical binding]; other site 273068001418 hydroxycobalamin binding site [chemical binding]; other site 273068001419 Walker B motif; other site 273068001420 Pfam match to entry CobA_CobO_BtuR, ATP:corrinoid adenosyltransferase BtuR/CobO/CobP, score 191.1, E-value 1.80E-53 273068001421 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 273068001422 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 273068001423 putative binding site residues; other site 273068001424 Pfam match to entry Peripla_BP_2, Periplasmic binding protein, score 200.8, E-value 2.10E-56 273068001425 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273068001426 ABC-ATPase subunit interface; other site 273068001427 dimer interface [polypeptide binding]; other site 273068001428 putative PBP binding regions; other site 273068001429 Pfam match to entry FecCD_family, FecCD transport family, score 370.5, E-value 1.70E-107 273068001430 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 273068001431 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273068001432 Walker A/P-loop; other site 273068001433 ATP binding site [chemical binding]; other site 273068001434 Q-loop/lid; other site 273068001435 ABC transporter signature motif; other site 273068001436 Walker B; other site 273068001437 D-loop; other site 273068001438 H-loop/switch region; other site 273068001439 Pfam match to entry ABC_tran, ABC transporter, score 194.3, E-value 1.90E-54 273068001440 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 273068001441 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 273068001442 catalytic triad [active] 273068001443 Pfam match to entry CbiA, Cobyrinic acid a,c-diamide synthase, score 192.5, E-value 6.50E-54 273068001444 cobyric acid synthase; Provisional; Region: PRK00784 273068001445 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001446 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001447 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 273068001448 catalytic triad [active] 273068001449 Pfam match to entry CbiA, Cobyrinic acid a,c-diamide synthase, score 293.5, E-value 2.50E-84 273068001450 CobD/Cbib protein; Region: CobD_Cbib; cl00561 273068001451 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 273068001452 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 273068001453 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 273068001454 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273068001455 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068001456 homodimer interface [polypeptide binding]; other site 273068001457 catalytic residue [active] 273068001458 Pfam match to entry aminotran_1, Aminotransferase class-I, score -44.7, E-value 1.60E-07 273068001459 Pfam match to entry aminotran_2, Aminotransferase class-II, score 18.9, E-value 4.00E-08 273068001460 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 273068001461 homotrimer interface [polypeptide binding]; other site 273068001462 Walker A motif; other site 273068001463 GTP binding site [chemical binding]; other site 273068001464 Walker B motif; other site 273068001465 Pfam match to entry CobU, Cobinamide kinase / cobinamide phosphate guanyltransferase, score 222.4, E-value 6.50E-63 273068001466 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 273068001467 Pfam match to entry CobS, Cobalamin-5-phosphate synthase, score 120.1, E-value 4.00E-32 273068001468 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647 273068001469 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001470 H-loop/switch region; other site 273068001471 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 273068001472 Pfam match to entry Band_7, SPFH domain / Band 7 family, score 359.6, E-value 3.40E-104 273068001473 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 273068001474 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 273068001475 dimer interface [polypeptide binding]; other site 273068001476 active site residues [active] 273068001477 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 273068001478 Pfam match to entry DUF107, Protein of unknown function DUF107, score 463.5, E-value 1.80E-135 273068001479 Yip1 domain; Region: Yip1; cl12048 273068001480 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 273068001481 Pfam match to entry isodh, Isocitrate and isopropylmalate dehydrogenases, score 266.7, E-value 4.80E-79 273068001482 acetylornithine deacetylase; Provisional; Region: PRK08652 273068001483 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 273068001484 metal binding site [ion binding]; metal-binding site 273068001485 dimer interface [polypeptide binding]; other site 273068001486 Pfam match to entry Peptidase_M20, Peptidase family M20/M25/M40, score 88.6, E-value 1.70E-24 273068001487 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 273068001488 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 84.7, E-value 1.90E-21 273068001489 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 273068001490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068001491 putative substrate translocation pore; other site 273068001492 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273068001493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001494 ABC transporter signature motif; other site 273068001495 Walker B; other site 273068001496 D-loop; other site 273068001497 H-loop/switch region; other site 273068001498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 273068001499 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 273068001500 Walker A/P-loop; other site 273068001501 ATP binding site [chemical binding]; other site 273068001502 Q-loop/lid; other site 273068001503 ABC transporter signature motif; other site 273068001504 Walker B; other site 273068001505 D-loop; other site 273068001506 H-loop/switch region; other site 273068001507 Pfam match to entry ABC_tran, ABC transporter, score 174.7, E-value 1.50E-48 273068001508 Rhomboid family; Region: Rhomboid; cl11446 273068001509 Pfam match to entry Rhomboid, Rhomboid family, score 115.4, E-value 1.10E-30 273068001510 Transposase domain (DUF772); Region: DUF772; cl12084 273068001511 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 273068001512 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 273068001513 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273068001514 dimerization interface [polypeptide binding]; other site 273068001515 DNA binding residues [nucleotide binding] 273068001516 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068001517 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 273068001518 active site triad [active] 273068001519 Protein of unknown function (DUF3796); Region: DUF3796; pfam12676 273068001520 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001521 Walker A/P-loop; other site 273068001522 ATP binding site [chemical binding]; other site 273068001523 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 273068001524 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001525 Walker A/P-loop; other site 273068001526 ATP binding site [chemical binding]; other site 273068001527 Q-loop/lid; other site 273068001528 ABC transporter signature motif; other site 273068001529 Walker B; other site 273068001530 D-loop; other site 273068001531 H-loop/switch region; other site 273068001532 Pfam match to entry ABC_tran, ABC transporter, score 194.4, E-value 1.80E-54 273068001533 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 273068001534 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 273068001535 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 273068001536 Helix-turn-helix domain; Region: HTH_16; pfam12645 273068001537 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068001538 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068001539 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068001540 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068001541 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 273068001542 Pfam match to entry Abi, CAAX amino terminal protease family, score 83.4, E-value 4.70E-21 273068001543 Protein of unknown function (DUF429); Region: DUF429; cl12046 273068001544 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 273068001545 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068001546 Membrane transport protein; Region: Mem_trans; cl09117 273068001547 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 273068001548 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068001549 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068001550 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068001551 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 67.7, E-value 2.50E-16 273068001552 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 273068001553 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068001554 DNA binding residues [nucleotide binding] 273068001555 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 273068001556 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 273068001557 Ycf48-like protein; Provisional; Region: PRK13684 273068001558 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 273068001559 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 273068001560 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 273068001561 Walker A/P-loop; other site 273068001562 ATP binding site [chemical binding]; other site 273068001563 Q-loop/lid; other site 273068001564 ABC transporter signature motif; other site 273068001565 Walker B; other site 273068001566 D-loop; other site 273068001567 H-loop/switch region; other site 273068001568 Pfam match to entry ABC_tran, ABC transporter, score 115.1, E-value 1.30E-30 273068001569 Predicted transcriptional regulators [Transcription]; Region: COG1725 273068001570 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273068001571 DNA-binding site [nucleotide binding]; DNA binding site 273068001572 Pfam match to entry gntR, Bacterial regulatory proteins, gntR family, score 54, E-value 3.90E-15 273068001573 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 273068001574 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 273068001575 oligomer interface [polypeptide binding]; other site 273068001576 active site 273068001577 metal binding site [ion binding]; metal-binding site 273068001578 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 273068001579 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 273068001580 oligomer interface [polypeptide binding]; other site 273068001581 active site 273068001582 metal binding site [ion binding]; metal-binding site 273068001583 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 273068001584 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 273068001585 oligomer interface [polypeptide binding]; other site 273068001586 active site 273068001587 metal binding site [ion binding]; metal-binding site 273068001588 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 273068001589 diiron binding motif [ion binding]; other site 273068001590 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 273068001591 CCC1-related family of proteins; Region: CCC1_like; cl00278 273068001592 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 273068001593 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273068001594 dimer interface [polypeptide binding]; other site 273068001595 PYR/PP interface [polypeptide binding]; other site 273068001596 TPP binding site [chemical binding]; other site 273068001597 substrate binding site [chemical binding]; other site 273068001598 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 273068001599 Domain of unknown function; Region: EKR; cl11037 273068001600 4Fe-4S binding domain; Region: Fer4; cl02805 273068001601 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273068001602 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 273068001603 TPP-binding site [chemical binding]; other site 273068001604 dimer interface [polypeptide binding]; other site 273068001605 Pfam match to entry fer4, 4Fe-4S binding domain, score 28.6, E-value 9.00E-05 273068001606 Pfam match to entry POR, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 287.9, E-value 1.20E-82 273068001607 Pfam match to entry POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 415.3, E-value 5.50E-121 273068001608 inner membrane transporter YjeM; Provisional; Region: PRK15238 273068001609 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 273068001610 Cache domain; Region: Cache_1; pfam02743 273068001611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068001612 dimerization interface [polypeptide binding]; other site 273068001613 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273068001614 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 273068001615 Pfam match to entry Cache, Cache domain, score 74.7, E-value 1.60E-19 273068001616 Pfam match to entry HAMP, HAMP domain, score 57.2, E-value 3.60E-13 273068001617 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 122.2, E-value 1.70E-33 273068001618 urocanate hydratase; Provisional; Region: PRK05414 273068001619 Pfam match to entry Urocanase, Urocanase, score 1159.2, E-value 0 273068001620 glutamate formiminotransferase; Region: FtcD; TIGR02024 273068001621 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 273068001622 Formiminotransferase domain; Region: FTCD; pfam02971 273068001623 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 273068001624 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 273068001625 active site 273068001626 Pfam match to entry ATZ_TRZ, Chlorohydrolase, score -33, E-value 8.30E-07 273068001627 Protein of unknown function DUF86; Region: DUF86; cl01031 273068001628 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 273068001629 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 273068001630 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 273068001631 ligand binding site [chemical binding]; other site 273068001632 Pfam match to entry Bmp, Basic membrane protein, score 362.7, E-value 3.90E-105 273068001633 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 273068001634 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 273068001635 Walker A/P-loop; other site 273068001636 ATP binding site [chemical binding]; other site 273068001637 Q-loop/lid; other site 273068001638 ABC transporter signature motif; other site 273068001639 Walker B; other site 273068001640 D-loop; other site 273068001641 H-loop/switch region; other site 273068001642 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 273068001643 Pfam match to entry ABC_tran, ABC transporter, score 213, E-value 4.50E-60 273068001644 Pfam match to entry ABC_tran, ABC transporter, score 42.3, E-value 1.10E-08 273068001645 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 273068001646 TM-ABC transporter signature motif; other site 273068001647 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 273068001648 TM-ABC transporter signature motif; other site 273068001649 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 273068001650 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273068001651 DNA-binding site [nucleotide binding]; DNA binding site 273068001652 UTRA domain; Region: UTRA; cl01230 273068001653 Pfam match to entry gntR, Bacterial regulatory proteins, gntR family, score 88.9, E-value 6.00E-26 273068001654 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 273068001655 active site 273068001656 catalytic motif [active] 273068001657 Zn binding site [ion binding]; other site 273068001658 Pfam match to entry dCMP_cyt_deam, Cytidine and deoxycytidylate deaminase zinc-binding region, score 106.5, E-value 5.00E-28 273068001659 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 273068001660 Sulfatase; Region: Sulfatase; cl10460 273068001661 Pfam match to entry Metalloenzyme, Metalloenzyme superfamily, score 126.9, E-value 3.70E-34 273068001662 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 273068001663 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 273068001664 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 273068001665 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 273068001666 Pfam match to entry Glycos_trans_3N, Glycosyl transferase family, helical bundle domain, score 65.8, E-value 9.20E-16 273068001667 Pfam match to entry Glycos_transf_3, Glycosyl transferase family, a/b domain, score 209.9, E-value 3.90E-59 273068001668 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273068001669 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273068001670 dimer interface [polypeptide binding]; other site 273068001671 putative CheW interface [polypeptide binding]; other site 273068001672 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 112.1, E-value 1.30E-30 273068001673 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 273068001674 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 273068001675 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 273068001676 active site turn [active] 273068001677 phosphorylation site [posttranslational modification] 273068001678 Pfam match to entry PTS_EIIC, Phosphotransferase system, EIIC, score 425.8, E-value 3.80E-124 273068001679 Pfam match to entry PTS_EIIB, phosphotransferase system, EIIB, score 56, E-value 1.30E-14 273068001680 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 273068001681 HPr interaction site; other site 273068001682 glycerol kinase (GK) interaction site [polypeptide binding]; other site 273068001683 active site 273068001684 phosphorylation site [posttranslational modification] 273068001685 Pfam match to entry PTS_EIIA_1, phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1, score 202.1, E-value 8.40E-57 273068001686 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 273068001687 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 273068001688 active site 273068001689 catalytic residues [active] 273068001690 metal binding site [ion binding]; metal-binding site 273068001691 Pfam match to entry HMGL-like, HMGL-like, score 392.5, E-value 4.20E-114 273068001692 aconitate hydratase; Validated; Region: PRK07229 273068001693 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 273068001694 substrate binding site [chemical binding]; other site 273068001695 ligand binding site [chemical binding]; other site 273068001696 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 273068001697 substrate binding site [chemical binding]; other site 273068001698 Pfam match to entry aconitase, Aconitase family (aconitate hydratase), score 413.1, E-value 1.20E-125 273068001699 Pfam match to entry Aconitase_C, Aconitase C-terminal domain, score 65, E-value 1.60E-15 273068001700 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 273068001701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068001702 Domain of unknown function (DUF4363); Region: DUF4363; pfam14276 273068001703 Protein of unknown function (DUF421); Region: DUF421; cl00990 273068001704 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068001705 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 273068001706 active site 273068001707 motif I; other site 273068001708 motif II; other site 273068001709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068001710 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068001711 catabolite control protein A; Region: ccpA; TIGR01481 273068001712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068001713 DNA binding site [nucleotide binding] 273068001714 domain linker motif; other site 273068001715 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 273068001716 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 47, E-value 7.30E-12 273068001717 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 98.2, E-value 1.60E-25 273068001718 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273068001719 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068001720 active site 273068001721 phosphorylation site [posttranslational modification] 273068001722 intermolecular recognition site; other site 273068001723 dimerization interface [polypeptide binding]; other site 273068001724 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273068001725 DNA binding site [nucleotide binding] 273068001726 Pfam match to entry response_reg, Response regulator receiver domain, score 156.6, E-value 4.40E-43 273068001727 Pfam match to entry trans_reg_C, Transcriptional regulatory protein, C terminal, score 120.5, E-value 9.20E-35 273068001728 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 273068001729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273068001730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068001731 dimerization interface [polypeptide binding]; other site 273068001732 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068001733 dimer interface [polypeptide binding]; other site 273068001734 phosphorylation site [posttranslational modification] 273068001735 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068001736 ATP binding site [chemical binding]; other site 273068001737 Mg2+ binding site [ion binding]; other site 273068001738 G-X-G motif; other site 273068001739 Pfam match to entry HAMP, HAMP domain, score 46.8, E-value 4.80E-10 273068001740 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 68, E-value 2.10E-16 273068001741 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 164.1, E-value 2.40E-45 273068001742 Sporulation and spore germination; Region: Germane; cl11253 273068001743 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 273068001744 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 273068001745 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 273068001746 SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057 273068001747 Rubrerythrin [Energy production and conversion]; Region: COG1592 273068001748 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 273068001749 binuclear metal center [ion binding]; other site 273068001750 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 273068001751 iron binding site [ion binding]; other site 273068001752 Pfam match to entry Rubrerythrin, Rubrerythrin, score 185.6, E-value 7.90E-52 273068001753 Pfam match to entry rubredoxin, Rubredoxin, score 27.3, E-value 2.90E-06 273068001754 S-adenosylmethionine synthetase; Validated; Region: PRK05250 273068001755 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 273068001756 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 273068001757 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 273068001758 Pfam match to entry S-AdoMet_synt, S-adenosylmethionine synthetase, N-terminal domain, score 202.8, E-value 4.80E-59 273068001759 Pfam match to entry S-AdoMet_syntD2, S-adenosylmethionine synthetase, central domain, score 270.7, E-value 1.90E-77 273068001760 Pfam match to entry S-AdoMet_syntD3, S-adenosylmethionine synthetase, C-terminal domain, score 288.5, E-value 8.20E-83 273068001761 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 273068001762 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001763 Pfam match to entry Viral_helicase1, Viral (Superfamily 1) RNA helicase, score 33, E-value 7.00E-09 273068001764 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 273068001765 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068001766 flagellar operon protein TIGR03826; Region: YvyF 273068001767 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 273068001768 FlgN protein; Region: FlgN; cl09176 273068001769 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 273068001770 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 273068001771 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 273068001772 Pfam match to entry flg_bb_rod, Flagella basal body rod protein, score 36.5, E-value 8.50E-08 273068001773 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 273068001774 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 273068001775 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 273068001776 Pfam match to entry Flagellin_N, Bacterial flagellin N-terminus, score 85, E-value 1.60E-21 273068001777 FliW protein; Region: FliW; cl00740 273068001778 Pfam match to entry DUF180, Uncharacterized BCR, COG1699, score 127.1, E-value 3.30E-34 273068001779 Global regulator protein family; Region: CsrA; cl00670 273068001780 Pfam match to entry CsrA, Carbon storage regulator, score 78.8, E-value 1.10E-19 273068001781 flagellin; Provisional; Region: PRK12804 273068001782 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 273068001783 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 273068001784 Pfam match to entry Flagellin_N, Bacterial flagellin N-terminus, score 260.4, E-value 2.30E-74 273068001785 Pfam match to entry Flagellin_C, Bacterial flagellin C-terminus, score 134.6, E-value 1.80E-36 273068001786 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 273068001787 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 273068001788 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 110.6, E-value 1.50E-29 273068001789 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 273068001790 putative metal binding site; other site 273068001791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 273068001792 binding surface 273068001793 TPR motif; other site 273068001794 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273068001795 binding surface 273068001796 TPR motif; other site 273068001797 Pfam match to entry Glycos_transf_2, Glycosyl transferase, score 107.4, E-value 2.70E-28 273068001798 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 273068001799 FlaG protein; Region: FlaG; cl00591 273068001800 flagellar capping protein; Validated; Region: fliD; PRK07737 273068001801 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 273068001802 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 273068001803 Pfam match to entry FliD, Flagellar hook-associated protein 2, score 239.9, E-value 3.60E-68 273068001804 Flagellar protein FliS; Region: FliS; cl00654 273068001805 Pfam match to entry FliS, Flagellar protein FliS, score 134.4, E-value 2.00E-36 273068001806 FlgN protein; Region: FlgN; cl09176 273068001807 Probable zinc-binding domain; Region: zf-trcl; pfam13451 273068001808 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 273068001809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 273068001810 substrate binding pocket [chemical binding]; other site 273068001811 membrane-bound complex binding site; other site 273068001812 hinge residues; other site 273068001813 Pfam match to entry SBP_bac_3, Bacterial extracellular solute-binding proteins, family 3, score 240.1, E-value 3.10E-68 273068001814 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 273068001815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068001816 dimer interface [polypeptide binding]; other site 273068001817 conserved gate region; other site 273068001818 putative PBP binding loops; other site 273068001819 ABC-ATPase subunit interface; other site 273068001820 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 75, E-value 1.60E-18 273068001821 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 273068001822 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 273068001823 Walker A/P-loop; other site 273068001824 ATP binding site [chemical binding]; other site 273068001825 Q-loop/lid; other site 273068001826 ABC transporter signature motif; other site 273068001827 Walker B; other site 273068001828 D-loop; other site 273068001829 H-loop/switch region; other site 273068001830 Pfam match to entry ABC_tran, ABC transporter, score 239.6, E-value 4.30E-68 273068001831 Transposase domain (DUF772); Region: DUF772; cl12084 273068001832 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 273068001833 30S subunit binding site; other site 273068001834 Pfam match to entry Ribosomal_S30, Sigma 54 modulation protein / S30EA ribosomal protein, score 73.8, E-value 3.60E-18 273068001835 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068001836 Zn2+ binding site [ion binding]; other site 273068001837 Mg2+ binding site [ion binding]; other site 273068001838 Pfam match to entry HD, HD domain, score 74, E-value 3.20E-18 273068001839 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 273068001840 Helix-turn-helix domains; Region: HTH; cl00088 273068001841 3H domain; Region: 3H; pfam02829 273068001842 Pfam match to entry 3H, 3H domain, score 121.3, E-value 1.80E-32 273068001843 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 273068001844 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001845 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 273068001846 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273068001847 nucleotide binding region [chemical binding]; other site 273068001848 Pfam match to entry SecA_protein, SecA protein, amino terminal region, score 1011, E-value 0 273068001849 Pfam match to entry SEC-C, SEC-C motif, score 44.4, E-value 2.50E-09 273068001850 peptide chain release factor 2; Validated; Region: prfB; PRK00578 273068001851 RF-1 domain; Region: RF-1; cl02875 273068001852 RF-1 domain; Region: RF-1; cl02875 273068001853 Pfam match to entry RF-1, Peptidyl-tRNA hydrolase domain, score 248.8, E-value 7.40E-71 273068001854 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 273068001855 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 273068001856 homodimer interface [polypeptide binding]; other site 273068001857 Walker A motif; other site 273068001858 ATP binding site [chemical binding]; other site 273068001859 hydroxycobalamin binding site [chemical binding]; other site 273068001860 Walker B motif; other site 273068001861 Pfam match to entry CobA_CobO_BtuR, ATP:corrinoid adenosyltransferase BtuR/CobO/CobP, score 206.5, E-value 4.10E-58 273068001862 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068001863 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068001864 DNA binding residues [nucleotide binding] 273068001865 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068001866 catalytic residues [active] 273068001867 catalytic nucleophile [active] 273068001868 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 29.4, E-value 9.00E-08 273068001869 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068001870 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068001871 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 273068001872 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 273068001873 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 273068001874 active site 273068001875 Pfam match to entry urease_C, Urease alpha-subunit, catalytic domain, score 23.8, E-value 9.40E-06 273068001876 Amidinotransferase; Region: Amidinotransf; cl12043 273068001877 Pfam match to entry Arg_deiminase, Arginine deiminase, score 311.1, E-value 1.40E-89 273068001878 ornithine carbamoyltransferase; Validated; Region: PRK02102 273068001879 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 273068001880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068001881 Pfam match to entry OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 261.4, E-value 1.20E-74 273068001882 Pfam match to entry OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 238.6, E-value 1.40E-69 273068001883 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 273068001884 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 273068001885 putative substrate binding site [chemical binding]; other site 273068001886 nucleotide binding site [chemical binding]; other site 273068001887 nucleotide binding site [chemical binding]; other site 273068001888 homodimer interface [polypeptide binding]; other site 273068001889 Pfam match to entry aakinase, Amino acid kinase family, score 334.4, E-value 1.30E-96 273068001890 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 273068001891 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 273068001892 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 273068001893 Pfam match to entry UPF0079, Uncharacterised P-loop hydrolase UPF0079, score 202, E-value 8.90E-57 273068001894 Glycoprotease family; Region: Peptidase_M22; pfam00814 273068001895 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 273068001896 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 273068001897 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273068001898 Coenzyme A binding pocket [chemical binding]; other site 273068001899 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 109.7, E-value 5.70E-29 273068001900 UGMP family protein; Validated; Region: PRK09604 273068001901 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 273068001902 Pfam match to entry Peptidase_M22, Glycoprotease family, score 502.5, E-value 3.20E-147 273068001903 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 273068001904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068001905 Pfam match to entry 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 129.8, E-value 4.80E-35 273068001906 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 273068001907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068001908 Walker A/P-loop; other site 273068001909 ATP binding site [chemical binding]; other site 273068001910 Q-loop/lid; other site 273068001911 ABC transporter signature motif; other site 273068001912 Walker B; other site 273068001913 D-loop; other site 273068001914 H-loop/switch region; other site 273068001915 ABC transporter; Region: ABC_tran_2; pfam12848 273068001916 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 273068001917 Pfam match to entry ABC_tran, ABC transporter, score 162.1, E-value 9.50E-45 273068001918 Pfam match to entry ABC_tran, ABC transporter, score 163, E-value 4.90E-45 273068001919 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 273068001920 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 273068001921 Pfam match to entry MotA_ExbB, MotA/TolQ/ExbB proton channel family, score 51.4, E-value 2.10E-11 273068001922 flagellar motor protein MotD; Reviewed; Region: PRK09038 273068001923 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 273068001924 ligand binding site [chemical binding]; other site 273068001925 Pfam match to entry OmpA, OmpA family, score 125.8, E-value 8.10E-34 273068001926 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 273068001927 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 273068001928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068001929 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 273068001930 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 273068001931 substrate binding site [chemical binding]; other site 273068001932 oxyanion hole (OAH) forming residues; other site 273068001933 trimer interface [polypeptide binding]; other site 273068001934 Pfam match to entry ECH, Enoyl-CoA hydratase/isomerase family, score 287, E-value 2.40E-82 273068001935 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 273068001936 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 273068001937 FAD binding site [chemical binding]; other site 273068001938 homotetramer interface [polypeptide binding]; other site 273068001939 substrate binding pocket [chemical binding]; other site 273068001940 catalytic base [active] 273068001941 Pfam match to entry Acyl-CoA_dh_N, Acyl-CoA dehydrogenase, N-terminal domain, score 159.6, E-value 5.40E-44 273068001942 Pfam match to entry Acyl-CoA_dh_M, Acyl-CoA dehydrogenase, middle domain, score 203.5, E-value 3.20E-57 273068001943 Pfam match to entry Acyl-CoA_dh, Acyl-CoA dehydrogenase, C-terminal domain, score 291.4, E-value 1.10E-83 273068001944 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 273068001945 Ligand binding site [chemical binding]; other site 273068001946 Electron transfer flavoprotein domain; Region: ETF; pfam01012 273068001947 Pfam match to entry ETF_beta, Electron transfer flavoprotein beta subunit, score 409.4, E-value 3.50E-119 273068001948 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 273068001949 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 273068001950 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 273068001951 Pfam match to entry ETF_alpha, Electron transfer flavoprotein alpha subunit, score 518.9, E-value 3.60E-152 273068001952 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 273068001953 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 273068001954 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 273068001955 Pfam match to entry 3HCDH_N, 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain, score 355.7, E-value 5.10E-103 273068001956 Pfam match to entry 3HCDH, 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain, score 186.8, E-value 3.40E-52 273068001957 putative acyltransferase; Provisional; Region: PRK05790 273068001958 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 273068001959 dimer interface [polypeptide binding]; other site 273068001960 active site 273068001961 Pfam match to entry thiolase, Thiolase, N-terminal domain, score 561.9, E-value 4.30E-165 273068001962 Pfam match to entry thiolase_C, Thiolase, C-terminal domain, score 277, E-value 2.40E-79 273068001963 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068001964 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 273068001965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068001966 Walker A motif; other site 273068001967 ATP binding site [chemical binding]; other site 273068001968 Walker B motif; other site 273068001969 arginine finger; other site 273068001970 Helix-turn-helix domains; Region: HTH; cl00088 273068001971 Pfam match to entry sigma54, Sigma-54 interaction domain, score 460.8, E-value 1.10E-134 273068001972 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 273068001973 dimer interaction site [polypeptide binding]; other site 273068001974 substrate-binding tunnel; other site 273068001975 active site 273068001976 catalytic site [active] 273068001977 substrate binding site [chemical binding]; other site 273068001978 Pfam match to entry MaoC_dehydratas, MaoC like domain, score 110.5, E-value 3.20E-29 273068001979 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 273068001980 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 273068001981 Pfam match to entry abhydrolase, alpha/beta hydrolase fold, score 117.6, E-value 2.30E-31 273068001982 hypothetical protein; Validated; Region: PRK06840 273068001983 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 273068001984 active site 273068001985 Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427 273068001986 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 273068001987 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 273068001988 Pfam match to entry AcetylCoA_hydro, Acetyl-CoA hydrolase/transferase, score 324.6, E-value 1.10E-93 273068001989 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 273068001990 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068001991 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 273068001992 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068001993 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068001994 Pfam match to entry abhydrolase, alpha/beta hydrolase fold, score 93.9, E-value 3.10E-24 273068001995 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 273068001996 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 273068001997 dimer interface [polypeptide binding]; other site 273068001998 active site 273068001999 CoA binding pocket [chemical binding]; other site 273068002000 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 273068002001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068002002 active site 273068002003 phosphorylation site [posttranslational modification] 273068002004 intermolecular recognition site; other site 273068002005 dimerization interface [polypeptide binding]; other site 273068002006 LytTr DNA-binding domain; Region: LytTR; cl04498 273068002007 Pfam match to entry response_reg, Response regulator receiver domain, score 95.7, E-value 9.40E-25 273068002008 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 273068002009 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068002010 ATP binding site [chemical binding]; other site 273068002011 Mg2+ binding site [ion binding]; other site 273068002012 G-X-G motif; other site 273068002013 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 45.6, E-value 3.00E-11 273068002014 Accessory gene regulator B; Region: AgrB; cl01873 273068002015 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 273068002016 Protein of unknown function (DUF322); Region: DUF322; cl00574 273068002017 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 273068002018 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 273068002019 FAD binding pocket [chemical binding]; other site 273068002020 FAD binding motif [chemical binding]; other site 273068002021 phosphate binding motif [ion binding]; other site 273068002022 beta-alpha-beta structure motif; other site 273068002023 NAD binding pocket [chemical binding]; other site 273068002024 Iron coordination center [ion binding]; other site 273068002025 putative oxidoreductase; Provisional; Region: PRK12831 273068002026 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273068002027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068002028 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 120.2, E-value 3.80E-32 273068002029 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068002030 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068002031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068002032 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 273068002033 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 273068002034 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273068002035 minor groove reading motif; other site 273068002036 helix-hairpin-helix signature motif; other site 273068002037 substrate binding pocket [chemical binding]; other site 273068002038 active site 273068002039 Pfam match to entry HhH-GPD, HhH-GPD superfamily base excision DNA repair protein, score 36.2, E-value 6.40E-08 273068002040 Protein of unknown function (DUF554); Region: DUF554; cl00784 273068002041 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 273068002042 active site 273068002043 catalytic triad [active] 273068002044 Pfam match to entry Peptidase_S8, Subtilase family, score 249.1, E-value 5.90E-71 273068002045 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 273068002046 oligomerisation interface [polypeptide binding]; other site 273068002047 mobile loop; other site 273068002048 roof hairpin; other site 273068002049 Pfam match to entry cpn10, Chaperonin 10 Kd subunit, score 208.3, E-value 1.10E-58 273068002050 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 273068002051 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 273068002052 ring oligomerisation interface [polypeptide binding]; other site 273068002053 ATP/Mg binding site [chemical binding]; other site 273068002054 stacking interactions; other site 273068002055 hinge regions; other site 273068002056 Pfam match to entry cpn60_TCP1, TCP-1/cpn60 chaperonin family, score 820.3, E-value 6.80E-243 273068002057 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273068002058 Coenzyme A binding pocket [chemical binding]; other site 273068002059 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 80.6, E-value 3.20E-20 273068002060 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 273068002061 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 273068002062 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 273068002063 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 273068002064 active site 273068002065 Pfam match to entry IMPDH_N, IMP dehydrogenase / GMP reductase N terminus, score 207.4, E-value 2.10E-58 273068002066 Pfam match to entry CBS, CBS domain, score 48.1, E-value 2.00E-10 273068002067 Pfam match to entry CBS, CBS domain, score 59.9, E-value 5.60E-14 273068002068 Pfam match to entry IMPDH_C, IMP dehydrogenase / GMP reductase C terminus, score 412, E-value 5.40E-120 273068002069 GMP synthase; Reviewed; Region: guaA; PRK00074 273068002070 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 273068002071 AMP/PPi binding site [chemical binding]; other site 273068002072 candidate oxyanion hole; other site 273068002073 catalytic triad [active] 273068002074 potential glutamine specificity residues [chemical binding]; other site 273068002075 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 273068002076 ATP Binding subdomain [chemical binding]; other site 273068002077 Ligand Binding sites [chemical binding]; other site 273068002078 Dimerization subdomain; other site 273068002079 Pfam match to entry GATase, Glutamine amidotransferase class-I, score 207.3, E-value 2.40E-58 273068002080 Pfam match to entry GMP_synt_C, GMP synthase C terminal domain, score 234.8, E-value 1.20E-66 273068002081 Permease family; Region: Xan_ur_permease; cl00967 273068002082 Pfam match to entry xan_ur_permease, Xanthine/uracil permeases family, score 120.6, E-value 2.90E-32 273068002083 AIR carboxylase; Region: AIRC; cl00310 273068002084 Pfam match to entry AIRC, AIR carboxylase, score 255.9, E-value 5.40E-73 273068002085 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068002086 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068002087 DNA binding residues [nucleotide binding] 273068002088 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068002089 catalytic residues [active] 273068002090 catalytic nucleophile [active] 273068002091 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 29.4, E-value 9.10E-08 273068002092 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068002093 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068002094 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 273068002095 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 273068002096 ATP binding site [chemical binding]; other site 273068002097 active site 273068002098 substrate binding site [chemical binding]; other site 273068002099 Pfam match to entry SAICAR_synt, SAICAR synthetase, score 322.3, E-value 5.70E-93 273068002100 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 273068002101 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 273068002102 dimerization interface [polypeptide binding]; other site 273068002103 putative ATP binding site [chemical binding]; other site 273068002104 Pfam match to entry AIRS, AIR synthase related protein, N-terminal domain, score 225.3, E-value 9.00E-64 273068002105 Pfam match to entry AIRS_C, AIR synthase related protein, C-terminal domain, score 201.5, E-value 1.30E-56 273068002106 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 273068002107 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 273068002108 active site 273068002109 substrate binding site [chemical binding]; other site 273068002110 cosubstrate binding site; other site 273068002111 catalytic site [active] 273068002112 Pfam match to entry formyl_transf, Formyl transferase, score 201.4, E-value 6.50E-57 273068002113 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 273068002114 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 273068002115 purine monophosphate binding site [chemical binding]; other site 273068002116 dimer interface [polypeptide binding]; other site 273068002117 putative catalytic residues [active] 273068002118 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 273068002119 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 273068002120 Pfam match to entry MGS, MGS-like domain, score 186.8, E-value 3.50E-52 273068002121 Pfam match to entry AICARFT_IMPCHas, AICARFT/IMPCHase bienzyme, score 534.1, E-value 9.80E-157 273068002122 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 273068002123 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 273068002124 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 273068002125 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 273068002126 Pfam match to entry GARS_N, Phosphoribosylglycinamide synthetase, N domain, score 195.9, E-value 6.40E-55 273068002127 Pfam match to entry GARS_B, Phosphoribosylglycinamide synthetase, B domain, score 96.1, E-value 6.70E-25 273068002128 Pfam match to entry GARS, Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain, score 272.3, E-value 6.20E-78 273068002129 Pfam match to entry GARS_C, Phosphoribosylglycinamide synthetase, C domain, score 114.6, E-value 1.90E-30 273068002130 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068002131 S-adenosylmethionine binding site [chemical binding]; other site 273068002132 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 273068002133 Pfam match to entry Asp_Glu_race, Asp/Glu/Hydontoin racemase, score 243.6, E-value 2.70E-69 273068002134 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 273068002135 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 273068002136 metal binding site [ion binding]; metal-binding site 273068002137 dimer interface [polypeptide binding]; other site 273068002138 Pfam match to entry Peptidase_M20, Peptidase family M20/M25/M40, score 194.5, E-value 7.30E-55 273068002139 stage V sporulation protein B; Region: spore_V_B; TIGR02900 273068002140 MatE; Region: MatE; cl10513 273068002141 Pfam match to entry Polysacc_synt, Polysaccharide biosynthesis protein, score 75.3, E-value 1.30E-18 273068002142 Helix-turn-helix domains; Region: HTH; cl00088 273068002143 PRD domain; Region: PRD; cl15445 273068002144 PRD domain; Region: PRD; cl15445 273068002145 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 273068002146 P-loop; other site 273068002147 active site 273068002148 phosphorylation site [posttranslational modification] 273068002149 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 273068002150 Pfam match to entry BglG_antitermin, Transcriptional antiterminator bglG family, score 80.8, E-value 2.80E-20 273068002151 Pfam match to entry BglG_antitermin, Transcriptional antiterminator bglG family, score 76.6, E-value 5.10E-19 273068002152 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 273068002153 active site 273068002154 P-loop; other site 273068002155 phosphorylation site [posttranslational modification] 273068002156 Pfam match to entry PTS_IIB, PTS system, Lactose/Cellobiose specific IIB subunit, score 77.6, E-value 2.60E-19 273068002157 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 273068002158 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 273068002159 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 273068002160 methionine cluster; other site 273068002161 active site 273068002162 phosphorylation site [posttranslational modification] 273068002163 metal binding site [ion binding]; metal-binding site 273068002164 Pfam match to entry PTS_IIA, PTS system, Lactose/Cellobiose specific IIA subunit, score 114.6, E-value 1.90E-30 273068002165 Trp repressor protein; Region: Trp_repressor; cl01121 273068002166 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 273068002167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068002168 Family description; Region: UvrD_C_2; cl15862 273068002169 Pfam match to entry UvrD-helicase, UvrD/REP helicase, score 728.3, E-value 3.50E-215 273068002170 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 273068002171 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 273068002172 nucleotide binding pocket [chemical binding]; other site 273068002173 K-X-D-G motif; other site 273068002174 catalytic site [active] 273068002175 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 273068002176 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 273068002177 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 273068002178 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 273068002179 Dimer interface [polypeptide binding]; other site 273068002180 BRCT sequence motif; other site 273068002181 Pfam match to entry DNA_ligase_N, NAD-dependent DNA ligase, score 567.3, E-value 1.00E-166 273068002182 Pfam match to entry BRCT, BRCA1 C Terminus (BRCT) domain, score 78.8, E-value 8.90E-23 273068002183 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 273068002184 Pfam match to entry Glu-tRNAGln, Glu-tRNAGln amidotransferase C subunit, score 97.6, E-value 2.40E-25 273068002185 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 273068002186 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 273068002187 Pfam match to entry Amidase, Amidase, score 727.9, E-value 4.50E-215 273068002188 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 273068002189 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 273068002190 GatB domain; Region: GatB_Yqey; cl11497 273068002191 Pfam match to entry PET112, PET112 family, score 660.4, E-value 9.60E-195 273068002192 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 273068002193 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273068002194 peptide binding site [polypeptide binding]; other site 273068002195 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 452.9, E-value 2.60E-132 273068002196 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 273068002197 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 273068002198 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273068002199 peptide binding site [polypeptide binding]; other site 273068002200 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 470.3, E-value 1.60E-137 273068002201 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273068002202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068002203 dimer interface [polypeptide binding]; other site 273068002204 conserved gate region; other site 273068002205 putative PBP binding loops; other site 273068002206 ABC-ATPase subunit interface; other site 273068002207 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 33.1, E-value 6.50E-06 273068002208 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273068002209 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273068002210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068002211 dimer interface [polypeptide binding]; other site 273068002212 conserved gate region; other site 273068002213 putative PBP binding loops; other site 273068002214 ABC-ATPase subunit interface; other site 273068002215 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 49.2, E-value 9.40E-11 273068002216 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273068002217 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068002218 Walker A/P-loop; other site 273068002219 ATP binding site [chemical binding]; other site 273068002220 Q-loop/lid; other site 273068002221 ABC transporter signature motif; other site 273068002222 Walker B; other site 273068002223 D-loop; other site 273068002224 H-loop/switch region; other site 273068002225 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068002226 Pfam match to entry ABC_tran, ABC transporter, score 222.7, E-value 5.50E-63 273068002227 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 273068002228 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068002229 Walker A/P-loop; other site 273068002230 ATP binding site [chemical binding]; other site 273068002231 Q-loop/lid; other site 273068002232 ABC transporter signature motif; other site 273068002233 Walker B; other site 273068002234 D-loop; other site 273068002235 H-loop/switch region; other site 273068002236 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068002237 Pfam match to entry ABC_tran, ABC transporter, score 213.7, E-value 2.90E-60 273068002238 ribonuclease PH; Reviewed; Region: rph; PRK00173 273068002239 Ribonuclease PH; Region: RNase_PH_bact; cd11362 273068002240 hexamer interface [polypeptide binding]; other site 273068002241 active site 273068002242 Pfam match to entry RNase_PH, 3' exoribonuclease family, score 286.5, E-value 3.40E-82 273068002243 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 273068002244 active site 273068002245 dimerization interface [polypeptide binding]; other site 273068002246 Pfam match to entry Ham1p_like, Ham1 family, score 237.5, E-value 1.80E-67 273068002247 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 273068002248 active site 273068002249 metal binding site [ion binding]; metal-binding site 273068002250 homotetramer interface [polypeptide binding]; other site 273068002251 Pfam match to entry UPF0025, Uncharacterized phosphoesterase family UPF0025, score 94.5, E-value 2.10E-24 273068002252 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 273068002253 trigger factor; Provisional; Region: tig; PRK01490 273068002254 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 273068002255 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 273068002256 Clp protease; Region: CLP_protease; pfam00574 273068002257 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 273068002258 oligomer interface [polypeptide binding]; other site 273068002259 active site residues [active] 273068002260 Pfam match to entry CLP_protease, Clp protease, score 402.2, E-value 5.10E-117 273068002261 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 273068002262 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 273068002263 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068002264 Walker A motif; other site 273068002265 ATP binding site [chemical binding]; other site 273068002266 Walker B motif; other site 273068002267 arginine finger; other site 273068002268 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 273068002269 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 90.2, E-value 4.10E-23 273068002270 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 273068002271 Found in ATP-dependent protease La (LON); Region: LON; smart00464 273068002272 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068002273 Walker A motif; other site 273068002274 ATP binding site [chemical binding]; other site 273068002275 Walker B motif; other site 273068002276 arginine finger; other site 273068002277 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 273068002278 Pfam match to entry LON, ATP-dependent protease La (LON) domain, score 130.9, E-value 2.30E-35 273068002279 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 164, E-value 2.40E-45 273068002280 Predicted GTPase [General function prediction only]; Region: COG0218 273068002281 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 273068002282 G1 box; other site 273068002283 GTP/Mg2+ binding site [chemical binding]; other site 273068002284 Switch I region; other site 273068002285 G2 box; other site 273068002286 G3 box; other site 273068002287 Switch II region; other site 273068002288 G4 box; other site 273068002289 G5 box; other site 273068002290 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 273068002291 ATP synthase A chain; Region: ATP-synt_A; cl00413 273068002292 Pfam match to entry ATP-synt_A, ATP synthase A chain, score 44, E-value 2.40E-09 273068002293 ATP synthase subunit C; Region: ATP-synt_C; cl00466 273068002294 Pfam match to entry ATP-synt_C, ATP synthase subunit C, score 72.3, E-value 1.00E-17 273068002295 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 273068002296 ATP synthase B/B' CF(0); Region: ATP-synt_B; pfam00430 273068002297 Pfam match to entry ATP-synt_B, ATP synthase B/B' CF(0), score 101.4, E-value 1.00E-27 273068002298 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 273068002299 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 273068002300 Pfam match to entry OSCP, ATP synthase delta (OSCP) subunit, score 140.1, E-value 2.00E-40 273068002301 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 273068002302 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 273068002303 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 273068002304 beta subunit interaction interface [polypeptide binding]; other site 273068002305 Walker A motif; other site 273068002306 ATP binding site [chemical binding]; other site 273068002307 Walker B motif; other site 273068002308 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 273068002309 Pfam match to entry ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain, score 89.8, E-value 5.30E-23 273068002310 Pfam match to entry ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 557.6, E-value 8.30E-164 273068002311 Pfam match to entry ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain, score 94, E-value 2.90E-24 273068002312 ATP synthase; Region: ATP-synt; cl00365 273068002313 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 273068002314 Pfam match to entry ATP-synt, ATP synthase, score 258.7, E-value 7.70E-74 273068002315 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 273068002316 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 273068002317 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 273068002318 alpha subunit interaction interface [polypeptide binding]; other site 273068002319 Walker A motif; other site 273068002320 ATP binding site [chemical binding]; other site 273068002321 Walker B motif; other site 273068002322 inhibitor binding site; inhibition site 273068002323 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 273068002324 Pfam match to entry ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain, score 106.7, E-value 4.40E-28 273068002325 Pfam match to entry ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 497.9, E-value 7.90E-146 273068002326 Pfam match to entry ATP-synt_ab_C, ATP synthase alpha/beta chain, C terminal domain, score 168.4, E-value 1.20E-46 273068002327 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 273068002328 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 273068002329 ATP synthase, Delta/Epsilon chain, long alpha-helix domain; Region: ATP-synt_DE; pfam00401 273068002330 Pfam match to entry ATP-synt_DE_N, ATP synthase, Delta/Epsilon chain, beta-sandwich domain, score 115.9, E-value 7.80E-31 273068002331 Pfam match to entry ATP-synt_DE, ATP synthase, Delta/Epsilon chain, long alpha-helix domain, score 33.3, E-value 5.60E-06 273068002332 EamA-like transporter family; Region: EamA; cl01037 273068002333 EamA-like transporter family; Region: EamA; cl01037 273068002334 Pfam match to entry DUF6, Integral membrane protein DUF6, score 72.7, E-value 7.60E-18 273068002335 Pfam match to entry DUF6, Integral membrane protein DUF6, score 79.8, E-value 5.70E-20 273068002336 NAD synthetase; Provisional; Region: PRK13981 273068002337 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 273068002338 multimer interface [polypeptide binding]; other site 273068002339 active site 273068002340 catalytic triad [active] 273068002341 protein interface 1 [polypeptide binding]; other site 273068002342 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 273068002343 homodimer interface [polypeptide binding]; other site 273068002344 NAD binding pocket [chemical binding]; other site 273068002345 ATP binding pocket [chemical binding]; other site 273068002346 Mg binding site [ion binding]; other site 273068002347 active-site loop [active] 273068002348 Pfam match to entry NAD_synthase, NAD synthase, score 306, E-value 4.60E-88 273068002349 Pfam match to entry CN_hydrolase, Carbon-nitrogen hydrolase, score -18.9, E-value 6.10E-08 273068002350 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 273068002351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068002352 dimer interface [polypeptide binding]; other site 273068002353 conserved gate region; other site 273068002354 putative PBP binding loops; other site 273068002355 ABC-ATPase subunit interface; other site 273068002356 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 273068002357 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 273068002358 Walker A/P-loop; other site 273068002359 ATP binding site [chemical binding]; other site 273068002360 Q-loop/lid; other site 273068002361 ABC transporter signature motif; other site 273068002362 Walker B; other site 273068002363 D-loop; other site 273068002364 H-loop/switch region; other site 273068002365 Pfam match to entry ABC_tran, ABC transporter, score 194.1, E-value 2.20E-54 273068002366 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 273068002367 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 273068002368 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 273068002369 O-Antigen ligase; Region: Wzy_C; cl04850 273068002370 TPR repeat; Region: TPR_11; pfam13414 273068002371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273068002372 binding surface 273068002373 TPR motif; other site 273068002374 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 273068002375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068002376 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 273068002377 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 102.2, E-value 8.80E-28 273068002378 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 273068002379 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 273068002380 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 273068002381 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 273068002382 inhibitor-cofactor binding pocket; inhibition site 273068002383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068002384 catalytic residue [active] 273068002385 Pfam match to entry DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family, score 608.2, E-value 4.90E-179 273068002386 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 273068002387 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 273068002388 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068002389 Pfam match to entry UDPG_MGDP_dh, UDP-glucose/GDP-mannose dehydrogenase family, score 489.9, E-value 2.00E-143 273068002390 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273068002391 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068002392 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 273068002393 Pfam match to entry GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 138.3, E-value 1.30E-37 273068002394 Pfam match to entry GFO_IDH_MocA_C, Oxidoreductase family, C-terminal alpha/beta domain, score 46.7, E-value 5.10E-10 273068002395 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 273068002396 putative trimer interface [polypeptide binding]; other site 273068002397 putative CoA binding site [chemical binding]; other site 273068002398 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 273068002399 putative trimer interface [polypeptide binding]; other site 273068002400 putative active site [active] 273068002401 putative substrate binding site [chemical binding]; other site 273068002402 putative CoA binding site [chemical binding]; other site 273068002403 Pfam match to entry hexapep, Bacterial transferase hexapeptide (four repeats), score 25.9, E-value 0.00095 273068002404 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 273068002405 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 123.5, E-value 3.90E-33 273068002406 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 273068002407 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 273068002408 putative ADP-binding pocket [chemical binding]; other site 273068002409 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 199.9, E-value 4.00E-56 273068002410 D-glucuronyl C5-epimerase C-terminus; Region: C5-epim_C; pfam06662 273068002411 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 273068002412 putative ADP-binding pocket [chemical binding]; other site 273068002413 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 154.5, E-value 1.80E-42 273068002414 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 273068002415 active site 273068002416 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 273068002417 homodimer interface [polypeptide binding]; other site 273068002418 Pfam match to entry Epimerase_2, UDP-N-acetylglucosamine 2-epimerase, score 512.8, E-value 2.50E-150 273068002419 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 273068002420 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 77.8, E-value 2.10E-20 273068002421 lipopolysaccharide 1,2-N-acetylglucosaminetransferase; Provisional; Region: PRK15484 273068002422 Bacterial sugar transferase; Region: Bac_transf; cl00939 273068002423 Pfam match to entry Bact_transf, Bacterial sugar transferase, score 209.4, E-value 5.60E-59 273068002424 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 273068002425 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 273068002426 putative trimer interface [polypeptide binding]; other site 273068002427 putative CoA binding site [chemical binding]; other site 273068002428 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 273068002429 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 273068002430 inhibitor-cofactor binding pocket; inhibition site 273068002431 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068002432 catalytic residue [active] 273068002433 Pfam match to entry DegT_DnrJ_EryC1, DegT/DnrJ/EryC1/StrS family, score 548.7, E-value 4.00E-161 273068002434 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 273068002435 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 273068002436 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 273068002437 NAD(P) binding site [chemical binding]; other site 273068002438 homodimer interface [polypeptide binding]; other site 273068002439 substrate binding site [chemical binding]; other site 273068002440 active site 273068002441 Pfam match to entry Polysacc_synt_2, Polysaccharide biosynthesis protein, score 817.5, E-value 4.90E-242 273068002442 Pfam match to entry Epimerase, NAD dependent epimerase/dehydratase f, score -62.2, E-value 1.40E-08 273068002443 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068002444 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068002445 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 77.3, E-value 3.10E-19 273068002446 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 273068002447 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 273068002448 putative active site [active] 273068002449 putative metal-binding site [ion binding]; other site 273068002450 Nuclease-related domain; Region: NERD; pfam08378 273068002451 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 273068002452 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 273068002453 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 273068002454 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 273068002455 putative substrate binding pocket [chemical binding]; other site 273068002456 AC domain interface; other site 273068002457 catalytic triad [active] 273068002458 AB domain interface; other site 273068002459 interchain disulfide; other site 273068002460 Pfam match to entry Peptidase_C15, Pyroglutamyl peptidase, score 380, E-value 2.40E-110 273068002461 AAA domain; Region: AAA_33; pfam13671 273068002462 Heme NO binding; Region: HNOB; cl15268 273068002463 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273068002464 dimer interface [polypeptide binding]; other site 273068002465 putative CheW interface [polypeptide binding]; other site 273068002466 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 107.2, E-value 3.40E-29 273068002467 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 273068002468 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 273068002469 active site 273068002470 metal binding site [ion binding]; metal-binding site 273068002471 homotetramer interface [polypeptide binding]; other site 273068002472 Pfam match to entry UPF0025, Uncharacterized phosphoesterase family UPF0025, score 89.3, E-value 7.90E-23 273068002473 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068002474 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068002475 DNA binding residues [nucleotide binding] 273068002476 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068002477 catalytic residues [active] 273068002478 catalytic nucleophile [active] 273068002479 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 29.4, E-value 9.00E-08 273068002480 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068002481 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068002482 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 273068002483 Pfam match to entry Nramp, Natural resistance-associated macrophage protein, score 189.3, E-value 6.20E-53 273068002484 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 273068002485 GAF domain; Region: GAF; cl15785 273068002486 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068002487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068002488 Walker A motif; other site 273068002489 ATP binding site [chemical binding]; other site 273068002490 Walker B motif; other site 273068002491 arginine finger; other site 273068002492 Helix-turn-helix domains; Region: HTH; cl00088 273068002493 Pfam match to entry sigma54, Sigma-54 interaction domain, score 438.2, E-value 7.20E-128 273068002494 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 273068002495 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 273068002496 tetramer interface [polypeptide binding]; other site 273068002497 TPP-binding site [chemical binding]; other site 273068002498 heterodimer interface [polypeptide binding]; other site 273068002499 phosphorylation loop region [posttranslational modification] 273068002500 Pfam match to entry E1_dehydrog, Dehydrogenase E1 component, score 374.6, E-value 1.00E-108 273068002501 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 273068002502 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 273068002503 alpha subunit interface [polypeptide binding]; other site 273068002504 TPP binding site [chemical binding]; other site 273068002505 heterodimer interface [polypeptide binding]; other site 273068002506 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273068002507 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 273068002508 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273068002509 E3 interaction surface; other site 273068002510 lipoyl attachment site [posttranslational modification]; other site 273068002511 e3 binding domain; Region: E3_binding; pfam02817 273068002512 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 273068002513 Pfam match to entry biotin_lipoyl, Biotin-requiring enzyme, score 57.5, E-value 3.00E-13 273068002514 Pfam match to entry e3_binding, e3 binding domain, score 78, E-value 1.90E-19 273068002515 Pfam match to entry 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain), score 188, E-value 1.50E-52 273068002516 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068002517 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068002518 DNA binding residues [nucleotide binding] 273068002519 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068002520 catalytic residues [active] 273068002521 catalytic nucleophile [active] 273068002522 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 31.2, E-value 2.60E-08 273068002523 putative oxidoreductase; Provisional; Region: PRK12831 273068002524 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273068002525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068002526 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 147, E-value 3.30E-40 273068002527 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 273068002528 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 273068002529 FAD binding pocket [chemical binding]; other site 273068002530 FAD binding motif [chemical binding]; other site 273068002531 phosphate binding motif [ion binding]; other site 273068002532 beta-alpha-beta structure motif; other site 273068002533 NAD binding pocket [chemical binding]; other site 273068002534 Iron coordination center [ion binding]; other site 273068002535 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 273068002536 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 273068002537 tetramer interface [polypeptide binding]; other site 273068002538 catalytic Zn binding site [ion binding]; other site 273068002539 NADP binding site [chemical binding]; other site 273068002540 Pfam match to entry adh_zinc, Zinc-binding dehydrogenases, score 281.3, E-value 1.20E-80 273068002541 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 273068002542 putative active site [active] 273068002543 metal binding site [ion binding]; metal-binding site 273068002544 Pfam match to entry Fe-ADH, Iron-containing alcohol dehydrogenase, score 164, E-value 4.80E-46 273068002545 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 273068002546 4Fe-4S binding domain; Region: Fer4; cl02805 273068002547 4Fe-4S binding domain; Region: Fer4; cl02805 273068002548 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 273068002549 Predicted NADH:ubiquinone oxidoreductase, subunit RnfB [Energy production and conversion]; Region: COG2878 273068002550 Putative Fe-S cluster; Region: FeS; pfam04060 273068002551 PAS domain S-box; Region: sensory_box; TIGR00229 273068002552 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273068002553 putative active site [active] 273068002554 heme pocket [chemical binding]; other site 273068002555 Pfam match to entry fer4, 4Fe-4S binding domain, score 25.4, E-value 0.00028 273068002556 Pfam match to entry fer4, 4Fe-4S binding domain, score 30.1, E-value 5.10E-05 273068002557 Pfam match to entry Fe_hyd_lg_C, 'Iron only hydrogenase large subunit, C-te', score -64.6, E-value 1.90E-10 273068002558 Pfam match to entry PAS, PAS domain, score 33.3, E-value 1.30E-07 273068002559 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 273068002560 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 273068002561 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 273068002562 putative CheA interaction surface; other site 273068002563 Pfam match to entry CheW, CheW-like domain, score 146.3, E-value 5.30E-40 273068002564 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 273068002565 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068002566 Pfam match to entry HD, HD domain, score 39.8, E-value 6.30E-08 273068002567 Cache domain; Region: Cache_1; pfam02743 273068002568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 273068002569 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273068002570 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 273068002571 Pfam match to entry Cache, Cache domain, score 83.8, E-value 4.60E-22 273068002572 Pfam match to entry HAMP, HAMP domain, score 35.9, E-value 9.30E-07 273068002573 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 111.5, E-value 2.00E-30 273068002574 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068002575 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068002576 DNA binding residues [nucleotide binding] 273068002577 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068002578 catalytic residues [active] 273068002579 catalytic nucleophile [active] 273068002580 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 26.3, E-value 8.00E-07 273068002581 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 273068002582 hypothetical protein; Reviewed; Region: PRK09588 273068002583 Pfam match to entry UPF0027, Uncharacterized protein family UPF0027, score 484.9, E-value 6.30E-142 273068002584 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068002585 active site 273068002586 NTP binding site [chemical binding]; other site 273068002587 metal binding triad [ion binding]; metal-binding site 273068002588 antibiotic binding site [chemical binding]; other site 273068002589 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068002590 active site 273068002591 NTP binding site [chemical binding]; other site 273068002592 metal binding triad [ion binding]; metal-binding site 273068002593 antibiotic binding site [chemical binding]; other site 273068002594 Pfam match to entry NTP_transf_2, Nucleotidyltransferase domain, score 64.7, E-value 2.00E-15 273068002595 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068002596 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068002597 DNA binding residues [nucleotide binding] 273068002598 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068002599 catalytic residues [active] 273068002600 catalytic nucleophile [active] 273068002601 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 273068002602 Probable transposase; Region: OrfB_IS605; pfam01385 273068002603 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068002604 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 273068002605 Pfam match to entry Transposase_2, Probable transposase, score -41.3, E-value 5.10E-06 273068002606 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 273068002607 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068002608 Beta-Casp domain; Region: Beta-Casp; cl12567 273068002609 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 273068002610 Pfam match to entry lactamase_B, Metallo-beta-lactamase superfamily, score 31.2, E-value 5.00E-06 273068002611 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 273068002612 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068002613 Walker A motif; other site 273068002614 ATP binding site [chemical binding]; other site 273068002615 Walker B motif; other site 273068002616 arginine finger; other site 273068002617 Helix-turn-helix domains; Region: HTH; cl00088 273068002618 Pfam match to entry sigma54, Sigma-54 interaction domain, score 400.8, E-value 1.30E-116 273068002619 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 273068002620 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 273068002621 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 273068002622 Pfam match to entry CoA_trans, Coenzyme A transferase, score 298.6, E-value 7.90E-86 273068002623 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 273068002624 Pfam match to entry CoA_trans, Coenzyme A transferase, score 347.5, E-value 1.50E-100 273068002625 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068002626 NAD(P) binding site [chemical binding]; other site 273068002627 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 273068002628 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068002629 FeS/SAM binding site; other site 273068002630 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 273068002631 Pfam match to entry DUF160, Uncharacterized ACR, YjeK family COG1509, score 569.5, E-value 2.10E-167 273068002632 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 273068002633 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 273068002634 Walker A/P-loop; other site 273068002635 ATP binding site [chemical binding]; other site 273068002636 Q-loop/lid; other site 273068002637 ABC transporter signature motif; other site 273068002638 Walker B; other site 273068002639 D-loop; other site 273068002640 H-loop/switch region; other site 273068002641 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 273068002642 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 273068002643 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 273068002644 B12 binding site [chemical binding]; other site 273068002645 Pfam match to entry B12-binding, B12 binding domain, score 116.3, E-value 5.90E-31 273068002646 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 273068002647 Amino acid permease; Region: AA_permease; cl00524 273068002648 Pfam match to entry aa_permeases, Amino acid permease, score -87.3, E-value 2.30E-09 273068002649 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 273068002650 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 273068002651 Pfam match to entry PhzC-PhzF, Phenazine biosynthesis-like protein, score 212.9, E-value 4.80E-60 273068002652 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 273068002653 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 273068002654 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 273068002655 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 273068002656 active site 273068002657 substrate binding site [chemical binding]; other site 273068002658 metal binding site [ion binding]; metal-binding site 273068002659 Pfam match to entry PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 160.3, E-value 3.40E-44 273068002660 Pfam match to entry PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 136.9, E-value 3.60E-37 273068002661 Pfam match to entry PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score 119.5, E-value 6.10E-32 273068002662 Pfam match to entry PGM_PMM, Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 38.5, E-value 1.50E-07 273068002663 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 273068002664 active site 273068002665 tetramer interface; other site 273068002666 Pfam match to entry NTP_transferase, Nucleotidyl transferase, score 87.8, E-value 2.20E-22 273068002667 Chain length determinant protein; Region: Wzz; cl01623 273068002668 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 273068002669 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068002670 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 273068002671 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 273068002672 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 273068002673 Helix-turn-helix domains; Region: HTH; cl00088 273068002674 dimerization interface [polypeptide binding]; other site 273068002675 putative DNA binding site [nucleotide binding]; other site 273068002676 putative Zn2+ binding site [ion binding]; other site 273068002677 Integrase core domain; Region: rve; cl01316 273068002678 Pfam match to entry rve, Integrase core domain, score 120.5, E-value 1.20E-33 273068002679 Chain length determinant protein; Region: Wzz; cl15801 273068002680 Chain length determinant protein; Region: Wzz; cl15801 273068002681 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068002682 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068002683 DNA binding residues [nucleotide binding] 273068002684 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068002685 catalytic residues [active] 273068002686 catalytic nucleophile [active] 273068002687 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 30.2, E-value 5.40E-08 273068002688 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068002689 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068002690 Uncharacterized membrane protein [Function unknown]; Region: COG3949 273068002691 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068002692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 273068002693 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 273068002694 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 273068002695 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 273068002696 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273068002697 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068002698 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 273068002699 Pfam match to entry Cation_ATPase_N, Cation transporter/ATPase, N-terminus, score 53.6, E-value 4.20E-12 273068002700 Pfam match to entry E1-E2_ATPase, E1-E2 ATPase, score 374.9, E-value 9.50E-113 273068002701 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 87.6, E-value 2.50E-22 273068002702 Pfam match to entry Cation_ATPase_C, Cation transporting ATPase, C-terminus, score 115.9, E-value 7.60E-31 273068002703 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 273068002704 active site 273068002705 multimer interface [polypeptide binding]; other site 273068002706 Pfam match to entry NDK, Nucleoside diphosphate kinases, score 275.1, E-value 8.90E-79 273068002707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068002708 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 273068002709 putative substrate translocation pore; other site 273068002710 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 273068002711 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068002712 active site 273068002713 NTP binding site [chemical binding]; other site 273068002714 metal binding triad [ion binding]; metal-binding site 273068002715 antibiotic binding site [chemical binding]; other site 273068002716 Pfam match to entry NTP_transf_2, Nucleotidyltransferase domain, score 70, E-value 4.90E-17 273068002717 Protein of unknown function DUF86; Region: DUF86; cl01031 273068002718 Protein of unknown function (DUF458); Region: DUF458; cl00861 273068002719 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 273068002720 active site 273068002721 Pfam match to entry PAP2, PAP2 superfamily, score 89.6, E-value 6.50E-23 273068002722 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 273068002723 Pfam match to entry CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase, score 82, E-value 1.20E-20 273068002724 Cache domain; Region: Cache_1; pfam02743 273068002725 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 273068002726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068002727 dimerization interface [polypeptide binding]; other site 273068002728 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273068002729 dimer interface [polypeptide binding]; other site 273068002730 putative CheW interface [polypeptide binding]; other site 273068002731 Pfam match to entry Cache, Cache domain, score 52.8, E-value 2.20E-13 273068002732 Pfam match to entry HAMP, HAMP domain, score 47.8, E-value 2.40E-10 273068002733 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 115.7, E-value 1.30E-31 273068002734 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273068002735 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068002736 DNA binding site [nucleotide binding] 273068002737 domain linker motif; other site 273068002738 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273068002739 dimerization interface [polypeptide binding]; other site 273068002740 ligand binding site [chemical binding]; other site 273068002741 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 43.7, E-value 6.60E-11 273068002742 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 45.3, E-value 1.40E-09 273068002743 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273068002744 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068002745 Pfam match to entry ROK, ROK family, score 206.7, E-value 2.10E-60 273068002746 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 273068002747 dimer interface [polypeptide binding]; other site 273068002748 active site 273068002749 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 273068002750 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 273068002751 Walker A/P-loop; other site 273068002752 ATP binding site [chemical binding]; other site 273068002753 Q-loop/lid; other site 273068002754 ABC transporter signature motif; other site 273068002755 Walker B; other site 273068002756 D-loop; other site 273068002757 H-loop/switch region; other site 273068002758 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 273068002759 Pfam match to entry ABC_tran, ABC transporter, score 205.5, E-value 8.30E-58 273068002760 Pfam match to entry ABC_tran, ABC transporter, score 84.8, E-value 1.70E-21 273068002761 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 273068002762 TM-ABC transporter signature motif; other site 273068002763 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 273068002764 putative ligand binding site [chemical binding]; other site 273068002765 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068002766 motif II; other site 273068002767 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 273068002768 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 273068002769 putative ribose interaction site [chemical binding]; other site 273068002770 putative ADP binding site [chemical binding]; other site 273068002771 Pfam match to entry pfkB, pfkB family carbohydrate kinase, score 42.2, E-value 1.20E-08 273068002772 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 273068002773 TIGR00268 family protein; Region: TIGR00268 273068002774 Ligand Binding Site [chemical binding]; other site 273068002775 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 273068002776 AIR carboxylase; Region: AIRC; cl00310 273068002777 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273068002778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068002779 dimerization interface [polypeptide binding]; other site 273068002780 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068002781 dimer interface [polypeptide binding]; other site 273068002782 phosphorylation site [posttranslational modification] 273068002783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068002784 ATP binding site [chemical binding]; other site 273068002785 G-X-G motif; other site 273068002786 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 142, E-value 1.00E-38 273068002787 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 91, E-value 2.30E-23 273068002788 Pfam match to entry HAMP, HAMP domain, score 54, E-value 3.40E-12 273068002789 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273068002790 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068002791 active site 273068002792 phosphorylation site [posttranslational modification] 273068002793 intermolecular recognition site; other site 273068002794 dimerization interface [polypeptide binding]; other site 273068002795 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273068002796 DNA binding site [nucleotide binding] 273068002797 Pfam match to entry trans_reg_C, Transcriptional regulatory protein, C terminal, score 119.8, E-value 1.50E-34 273068002798 Pfam match to entry response_reg, Response regulator receiver domain, score 139.5, E-value 5.80E-38 273068002799 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 273068002800 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 273068002801 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 273068002802 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 273068002803 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 273068002804 Pfam match to entry BioY, BioY family, score 139.4, E-value 6.30E-38 273068002805 Bifunctional nuclease; Region: DNase-RNase; cl00553 273068002806 Pfam match to entry DUF151, Uncharacterized ACR, COG1259, score 120.7, E-value 2.70E-32 273068002807 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 273068002808 Protein of unknown function (DUF3834); Region: DUF3834; pfam12916 273068002809 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 273068002810 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 273068002811 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273068002812 active site 273068002813 HIGH motif; other site 273068002814 nucleotide binding site [chemical binding]; other site 273068002815 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 273068002816 active site 273068002817 KMSKS motif; other site 273068002818 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 273068002819 tRNA binding surface [nucleotide binding]; other site 273068002820 anticodon binding site; other site 273068002821 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 273068002822 Pfam match to entry tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 1002.5, E-value 9.80E-298 273068002823 putative acetyltransferase YhhY; Provisional; Region: PRK10140 273068002824 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 273068002825 Coenzyme A binding pocket [chemical binding]; other site 273068002826 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 91.9, E-value 1.30E-23 273068002827 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 273068002828 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273068002829 Pfam match to entry Mur_ligase, Mur ligase family, catalytic domain, score 90.3, E-value 9.00E-26 273068002830 Pfam match to entry Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 50.1, E-value 4.80E-11 273068002831 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068002832 non-specific DNA binding site [nucleotide binding]; other site 273068002833 salt bridge; other site 273068002834 sequence-specific DNA binding site [nucleotide binding]; other site 273068002835 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 273068002836 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273068002837 TPR motif; other site 273068002838 binding surface 273068002839 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068002840 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068002841 putative substrate translocation pore; other site 273068002842 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273068002843 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068002844 Walker A/P-loop; other site 273068002845 ATP binding site [chemical binding]; other site 273068002846 Q-loop/lid; other site 273068002847 ABC transporter signature motif; other site 273068002848 Walker B; other site 273068002849 D-loop; other site 273068002850 H-loop/switch region; other site 273068002851 Pfam match to entry ABC_tran, ABC transporter, score 169.8, E-value 4.40E-47 273068002852 Uncharacterized conserved protein [Function unknown]; Region: COG3391 273068002853 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 273068002854 Domain of unknown function (DUF4364); Region: DUF4364; pfam14277 273068002855 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 273068002856 Pfam match to entry SASP, Small, acid-soluble spore proteins, alpha/beta type, score 66.7, E-value 3.70E-17 273068002857 iron-sulfur cluster binding protein, putative; Region: TIGR00276 273068002858 Reductive dehalogenase subunit; Region: Dehalogenase; pfam13486 273068002859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273068002860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068002861 DNA binding site [nucleotide binding] 273068002862 domain linker motif; other site 273068002863 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 273068002864 dimerization interface [polypeptide binding]; other site 273068002865 ligand binding site [chemical binding]; other site 273068002866 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 49.3, E-value 1.50E-12 273068002867 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 121.1, E-value 2.00E-32 273068002868 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 273068002869 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 273068002870 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 273068002871 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 273068002872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273068002873 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068002874 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068002875 Pfam match to entry SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 221.5, E-value 1.20E-62 273068002876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 273068002877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068002878 dimer interface [polypeptide binding]; other site 273068002879 putative PBP binding loops; other site 273068002880 ABC-ATPase subunit interface; other site 273068002881 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 68.3, E-value 1.60E-16 273068002882 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273068002883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068002884 dimer interface [polypeptide binding]; other site 273068002885 conserved gate region; other site 273068002886 putative PBP binding loops; other site 273068002887 ABC-ATPase subunit interface; other site 273068002888 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 88, E-value 1.90E-22 273068002889 beta-phosphoglucomutase; Region: bPGM; TIGR01990 273068002890 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068002891 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068002892 motif II; other site 273068002893 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 137.3, E-value 2.80E-37 273068002894 catabolite control protein A; Region: ccpA; TIGR01481 273068002895 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 44.8, E-value 3.20E-11 273068002896 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 124.2, E-value 2.40E-33 273068002897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068002898 dimer interface [polypeptide binding]; other site 273068002899 conserved gate region; other site 273068002900 putative PBP binding loops; other site 273068002901 ABC-ATPase subunit interface; other site 273068002902 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 73.7, E-value 3.90E-18 273068002903 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273068002904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068002905 dimer interface [polypeptide binding]; other site 273068002906 conserved gate region; other site 273068002907 putative PBP binding loops; other site 273068002908 ABC-ATPase subunit interface; other site 273068002909 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 58.5, E-value 1.40E-13 273068002910 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273068002911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068002912 Pfam match to entry SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 133.2, E-value 4.60E-36 273068002913 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 273068002914 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 273068002915 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 273068002916 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 273068002917 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt; cl00231 273068002918 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 273068002919 Pfam match to entry UPF0062, Uncharacterized ACR, YexA/UPF0062 family, score 136.5, E-value 4.80E-37 273068002920 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 273068002921 putative active site [active] 273068002922 catalytic triad [active] 273068002923 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 273068002924 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 273068002925 dimerization interface [polypeptide binding]; other site 273068002926 ATP binding site [chemical binding]; other site 273068002927 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 273068002928 dimerization interface [polypeptide binding]; other site 273068002929 ATP binding site [chemical binding]; other site 273068002930 Pfam match to entry AIRS, AIR synthase related protein, N-terminal domain, score 196.3, E-value 4.80E-55 273068002931 Pfam match to entry AIRS_C, AIR synthase related protein, C-terminal domain, score 169.2, E-value 6.70E-47 273068002932 Pfam match to entry AIRS, AIR synthase related protein, N-terminal domain, score 146.4, E-value 4.90E-40 273068002933 Pfam match to entry AIRS_C, AIR synthase related protein, C-terminal domain, score 91.2, E-value 1.40E-24 273068002934 amidophosphoribosyltransferase; Provisional; Region: PRK05793 273068002935 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 273068002936 active site 273068002937 tetramer interface [polypeptide binding]; other site 273068002938 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 273068002939 active site 273068002940 Pfam match to entry GATase_2, Glutamine amidotransferases class-II, score 238.9, E-value 7.40E-81 273068002941 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 49.7, E-value 6.40E-11 273068002942 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 273068002943 Aspartase; Region: Aspartase; cd01357 273068002944 active sites [active] 273068002945 tetramer interface [polypeptide binding]; other site 273068002946 Pfam match to entry lyase_1, Lyase, score 520, E-value 1.70E-152 273068002947 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 273068002948 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 273068002949 G1 box; other site 273068002950 GTP/Mg2+ binding site [chemical binding]; other site 273068002951 Switch I region; other site 273068002952 G2 box; other site 273068002953 Switch II region; other site 273068002954 G3 box; other site 273068002955 G4 box; other site 273068002956 G5 box; other site 273068002957 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 273068002958 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 273068002959 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 273068002960 catalytic site [active] 273068002961 subunit interface [polypeptide binding]; other site 273068002962 Pfam match to entry CPSase_sm_chain, Carbamoyl-phosphate synthase small chain, CPSase domain, score 269.5, E-value 3.70E-81 273068002963 Pfam match to entry GATase, Glutamine amidotransferase class-I, score 216.2, E-value 5.00E-61 273068002964 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 273068002965 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273068002966 ATP-grasp domain; Region: ATP-grasp_4; cl03087 273068002967 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 273068002968 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 273068002969 ATP-grasp domain; Region: ATP-grasp_4; cl03087 273068002970 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 273068002971 IMP binding site; other site 273068002972 dimer interface [polypeptide binding]; other site 273068002973 interdomain contacts; other site 273068002974 partial ornithine binding site; other site 273068002975 Pfam match to entry CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 194.1, E-value 2.30E-54 273068002976 Pfam match to entry CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 480.8, E-value 1.10E-140 273068002977 Pfam match to entry CPSase_L_D3, Carbamoyl-phosphate synthetase large chain, oligomerisation domain, score 233.1, E-value 4.10E-66 273068002978 Pfam match to entry CPSase_L_chain, Carbamoyl-phosphate synthase L chain, N-terminal domain, score 97.9, E-value 7.40E-26 273068002979 Pfam match to entry CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 112.3, E-value 5.30E-31 273068002980 Pfam match to entry MGS, MGS-like domain, score 84.6, E-value 2.10E-21 273068002981 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 273068002982 active site 273068002983 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 273068002984 dimer interface [polypeptide binding]; other site 273068002985 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 273068002986 Ligand Binding Site [chemical binding]; other site 273068002987 Molecular Tunnel; other site 273068002988 Pfam match to entry Asn_synthase, Asparagine synthase, score 191.6, E-value 1.30E-53 273068002989 Pfam match to entry GATase_2, Glutamine amidotransferases class-II, score 62.3, E-value 1.30E-20 273068002990 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 273068002991 putative subunit interface; other site 273068002992 Pfam match to entry DUF14, Domain of unknown function DUF14, score 144.5, E-value 1.90E-39 273068002993 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 273068002994 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 273068002995 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 273068002996 active site 273068002997 FMN binding site [chemical binding]; other site 273068002998 substrate binding site [chemical binding]; other site 273068002999 3Fe-4S cluster binding site [ion binding]; other site 273068003000 Pfam match to entry Glu_synthase, Conserved region in glutamate synthase, score 686.9, E-value 1.00E-202 273068003001 Pfam match to entry fer4, 4Fe-4S binding domain, score 24, E-value 0.00047 273068003002 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 273068003003 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 273068003004 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 273068003005 putative active site [active] 273068003006 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 273068003007 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 273068003008 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 273068003009 Pfam match to entry gln-synt, Glutamine synthetase, score 35.5, E-value 8.90E-11 273068003010 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 273068003011 predicted active site [active] 273068003012 catalytic triad [active] 273068003013 Pfam match to entry SNO, SNO glutamine amidotransferase family, score 236.1, E-value 4.90E-67 273068003014 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 273068003015 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 273068003016 active site 273068003017 multimer interface [polypeptide binding]; other site 273068003018 Pfam match to entry SOR_SNZ, SOR/SNZ family, score 440.2, E-value 1.80E-128 273068003019 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 273068003020 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 273068003021 active site 273068003022 catalytic triad [active] 273068003023 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 273068003024 Pfam match to entry Peptidase_S8, Subtilase family, score 212.6, E-value 5.90E-60 273068003025 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 273068003026 Helix-turn-helix domains; Region: HTH; cl00088 273068003027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068003028 Walker A motif; other site 273068003029 ATP binding site [chemical binding]; other site 273068003030 Walker B motif; other site 273068003031 arginine finger; other site 273068003032 Pfam match to entry sigma54, Sigma-54 interaction domain, score 77.4, E-value 1.50E-20 273068003033 YibE/F-like protein; Region: YibE_F; cl02259 273068003034 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068003035 putative peptidoglycan binding site; other site 273068003036 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 273068003037 Pfam match to entry LysM, LysM domain, score 38.3, E-value 1.70E-07 273068003038 single-stranded DNA-binding protein; Provisional; Region: PRK05813 273068003039 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 273068003040 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273068003041 dimer interface [polypeptide binding]; other site 273068003042 ssDNA binding site [nucleotide binding]; other site 273068003043 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273068003044 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 273068003045 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 273068003046 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 273068003047 active site 273068003048 trimer interface [polypeptide binding]; other site 273068003049 substrate binding site [chemical binding]; other site 273068003050 CoA binding site [chemical binding]; other site 273068003051 dihydrodipicolinate reductase; Provisional; Region: PRK00048 273068003052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068003053 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 273068003054 Pfam match to entry DapB, Dihydrodipicolinate reductase, score 180.6, E-value 2.60E-50 273068003055 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 273068003056 dihydrodipicolinate synthase; Region: dapA; TIGR00674 273068003057 dimer interface [polypeptide binding]; other site 273068003058 active site 273068003059 catalytic residue [active] 273068003060 Pfam match to entry DHDPS, Dihydrodipicolinate synthetase family, score 416.3, E-value 2.80E-121 273068003061 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 273068003062 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068003063 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 273068003064 Pfam match to entry Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain, score 229.4, E-value 5.30E-65 273068003065 Pfam match to entry Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain, score 187.5, E-value 1.40E-59 273068003066 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068003067 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068003068 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 273068003069 Walker A/P-loop; other site 273068003070 ATP binding site [chemical binding]; other site 273068003071 Q-loop/lid; other site 273068003072 ABC transporter signature motif; other site 273068003073 Walker B; other site 273068003074 D-loop; other site 273068003075 H-loop/switch region; other site 273068003076 Pfam match to entry ABC_tran, ABC transporter, score 223.1, E-value 4.00E-63 273068003077 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 166.6, E-value 4.20E-46 273068003078 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068003079 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 273068003080 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 273068003081 Walker A/P-loop; other site 273068003082 ATP binding site [chemical binding]; other site 273068003083 Q-loop/lid; other site 273068003084 ABC transporter signature motif; other site 273068003085 Walker B; other site 273068003086 D-loop; other site 273068003087 H-loop/switch region; other site 273068003088 Pfam match to entry ABC_tran, ABC transporter, score 205.8, E-value 6.40E-58 273068003089 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 188.4, E-value 1.10E-52 273068003090 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 273068003091 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 273068003092 dimer interface [polypeptide binding]; other site 273068003093 active site 273068003094 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068003095 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 273068003096 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273068003097 DNA-binding site [nucleotide binding]; DNA binding site 273068003098 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273068003099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068003100 homodimer interface [polypeptide binding]; other site 273068003101 catalytic residue [active] 273068003102 Pfam match to entry gntR, Bacterial regulatory proteins, gntR family, score 42.9, E-value 1.10E-11 273068003103 Pfam match to entry aminotran_1, Aminotransferase class-I, score -12.5, E-value 3.20E-09 273068003104 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 273068003105 Plant protein of unknown function (DUF869); Region: DUF869; pfam05911 273068003106 Peptidase family M23; Region: Peptidase_M23; pfam01551 273068003107 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 273068003108 Pfam match to entry Peptidase_M37, Peptidase family M23/M37, score 160.3, E-value 3.20E-44 273068003109 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 273068003110 active sites [active] 273068003111 tetramer interface [polypeptide binding]; other site 273068003112 Pfam match to entry PAL, Phenylalanine and histidine ammonia-lyase, score 801.3, E-value 1.10E-248 273068003113 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068003114 Transposase domain (DUF772); Region: DUF772; cl15789 273068003115 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 273068003116 Transposase domain (DUF772); Region: DUF772; cl15789 273068003117 NlpC/P60 family; Region: NLPC_P60; cl11438 273068003118 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 273068003119 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 273068003120 Walker A/P-loop; other site 273068003121 ATP binding site [chemical binding]; other site 273068003122 Q-loop/lid; other site 273068003123 ABC transporter signature motif; other site 273068003124 Walker B; other site 273068003125 D-loop; other site 273068003126 H-loop/switch region; other site 273068003127 Pfam match to entry ABC_tran, ABC transporter, score 191.7, E-value 1.20E-53 273068003128 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 273068003129 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 273068003130 tandem repeat interface [polypeptide binding]; other site 273068003131 oligomer interface [polypeptide binding]; other site 273068003132 active site residues [active] 273068003133 Pfam match to entry Peptidase_U7, Peptidase family U7, score 262.1, E-value 7.30E-75 273068003134 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 273068003135 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068003136 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068003137 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068003138 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068003139 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068003140 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068003141 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068003142 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 273068003143 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 273068003144 Pfam match to entry sodfe_C, Iron/manganese superoxide dismutases, C-terminal domain, score 52.2, E-value 7.30E-15 273068003145 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 273068003146 Protein of unknown function (DUF436); Region: DUF436; cl01860 273068003147 germination protein YpeB; Region: spore_YpeB; TIGR02889 273068003148 S-layer homology domain; Region: SLH; pfam00395 273068003149 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 273068003150 active site 273068003151 Glyco_18 domain; Region: Glyco_18; smart00636 273068003152 PspC domain; Region: PspC; cl00864 273068003153 Transposase domain (DUF772); Region: DUF772; cl15789 273068003154 Transposase domain (DUF772); Region: DUF772; cl15789 273068003155 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 273068003156 NodB motif; other site 273068003157 active site 273068003158 catalytic site [active] 273068003159 metal binding site [ion binding]; metal-binding site 273068003160 Pfam match to entry Polysac_deacet, Polysaccharide deacetylase, score 196.3, E-value 4.80E-55 273068003161 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 273068003162 Carbon starvation protein CstA; Region: CstA; pfam02554 273068003163 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 273068003164 Pfam match to entry CstA, Carbon starvation protein CstA, score 640.7, E-value 7.70E-189 273068003165 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 273068003166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068003167 active site 273068003168 phosphorylation site [posttranslational modification] 273068003169 intermolecular recognition site; other site 273068003170 dimerization interface [polypeptide binding]; other site 273068003171 LytTr DNA-binding domain; Region: LytTR; cl04498 273068003172 Pfam match to entry response_reg, Response regulator receiver domain, score 105.5, E-value 1.00E-27 273068003173 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 273068003174 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 273068003175 Histidine kinase; Region: His_kinase; pfam06580 273068003176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068003177 ATP binding site [chemical binding]; other site 273068003178 Mg2+ binding site [ion binding]; other site 273068003179 G-X-G motif; other site 273068003180 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 63.3, E-value 3.90E-16 273068003181 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 273068003182 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068003183 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068003184 DNA binding residues [nucleotide binding] 273068003185 Pfam match to entry Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 91.6, E-value 1.60E-23 273068003186 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 273068003187 DNA polymerase I; Provisional; Region: PRK05755 273068003188 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 273068003189 active site 273068003190 metal binding site 1 [ion binding]; metal-binding site 273068003191 putative 5' ssDNA interaction site; other site 273068003192 metal binding site 3; metal-binding site 273068003193 metal binding site 2 [ion binding]; metal-binding site 273068003194 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 273068003195 putative DNA binding site [nucleotide binding]; other site 273068003196 putative metal binding site [ion binding]; other site 273068003197 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 273068003198 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 273068003199 active site 273068003200 DNA binding site [nucleotide binding] 273068003201 catalytic site [active] 273068003202 Pfam match to entry 5_3_exonuc_N, 5'-3' exonuclease, N-terminal resolvase-like domain, score 304, E-value 1.90E-87 273068003203 Pfam match to entry 5_3_exonuclease, 5'-3' exonuclease, C-terminal SAM fold, score 180.7, E-value 1.70E-53 273068003204 Pfam match to entry DNA_pol_A, DNA polymerase family A, score 602.7, E-value 2.20E-177 273068003205 dephospho-CoA kinase; Region: TIGR00152 273068003206 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 273068003207 CoA-binding site [chemical binding]; other site 273068003208 ATP-binding [chemical binding]; other site 273068003209 Pfam match to entry UPF0038, Uncharacterized protein family UPF0038, score 272, E-value 7.60E-78 273068003210 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 273068003211 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273068003212 catalytic residue [active] 273068003213 Pfam match to entry SLT, Transglycosylase SLT domain, score 134.9, E-value 1.50E-36 273068003214 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 273068003215 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 273068003216 active site 273068003217 Pfam match to entry QRPTase_N, Quinolinate phosphoribosyl transferase, N-terminal domain, score 37.2, E-value 2.30E-09 273068003218 Pfam match to entry QRPTase, Quinolinate phosphoribosyl transferase, C-terminal domain, score 44.7, E-value 4.70E-12 273068003219 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 273068003220 peptide binding site [polypeptide binding]; other site 273068003221 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 273068003222 dimer interface [polypeptide binding]; other site 273068003223 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 202.8, E-value 5.20E-57 273068003224 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 273068003225 Helix-turn-helix domains; Region: HTH; cl00088 273068003226 dimerization interface [polypeptide binding]; other site 273068003227 putative DNA binding site [nucleotide binding]; other site 273068003228 putative Zn2+ binding site [ion binding]; other site 273068003229 Integrase core domain; Region: rve; cl01316 273068003230 Pfam match to entry rve, Integrase core domain, score 120.5, E-value 1.20E-33 273068003231 Bacterial SH3 domain; Region: SH3_3; cl02551 273068003232 Bacterial SH3 domain; Region: SH3_3; cl02551 273068003233 NlpC/P60 family; Region: NLPC_P60; cl11438 273068003234 Pfam match to entry NLPC_P60, NLP/P60 family, score 185.8, E-value 6.80E-52 273068003235 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 273068003236 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 273068003237 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 273068003238 G1 box; other site 273068003239 putative GEF interaction site [polypeptide binding]; other site 273068003240 GTP/Mg2+ binding site [chemical binding]; other site 273068003241 Switch I region; other site 273068003242 G2 box; other site 273068003243 G3 box; other site 273068003244 Switch II region; other site 273068003245 G4 box; other site 273068003246 G5 box; other site 273068003247 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 273068003248 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 273068003249 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 335.1, E-value 8.00E-97 273068003250 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 273068003251 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273068003252 catalytic residue [active] 273068003253 Pfam match to entry SLT, Transglycosylase SLT domain, score 143.7, E-value 3.30E-39 273068003254 Sporulation related domain; Region: SPOR; cl10051 273068003255 DRTGG domain; Region: DRTGG; cl12147 273068003256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 273068003257 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 273068003258 4Fe-4S binding domain; Region: Fer4; cl02805 273068003259 4Fe-4S binding domain; Region: Fer4; cl02805 273068003260 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 273068003261 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 273068003262 Putative Fe-S cluster; Region: FeS; pfam04060 273068003263 Pfam match to entry fer4, 4Fe-4S binding domain, score 32.2, E-value 1.20E-05 273068003264 Pfam match to entry fer4, 4Fe-4S binding domain, score 29.7, E-value 6.10E-05 273068003265 Pfam match to entry Fe_hyd_lg_C, 'Iron only hydrogenase large subunit, C-te', score -119.1, E-value 4.30E-07 273068003266 DRTGG domain; Region: DRTGG; cl12147 273068003267 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 273068003268 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 273068003269 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 273068003270 putative dimer interface [polypeptide binding]; other site 273068003271 [2Fe-2S] cluster binding site [ion binding]; other site 273068003272 Pfam match to entry complex1_24kD, Respiratory-chain NADH dehydrogenase 24 Kd subunit, score 133.2, E-value 4.70E-36 273068003273 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068003274 ATP binding site [chemical binding]; other site 273068003275 Mg2+ binding site [ion binding]; other site 273068003276 G-X-G motif; other site 273068003277 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 55.7, E-value 4.90E-14 273068003278 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 273068003279 dimer interface [polypeptide binding]; other site 273068003280 [2Fe-2S] cluster binding site [ion binding]; other site 273068003281 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 273068003282 dimer interface [polypeptide binding]; other site 273068003283 [2Fe-2S] cluster binding site [ion binding]; other site 273068003284 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 273068003285 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 273068003286 SLBB domain; Region: SLBB; pfam10531 273068003287 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 273068003288 4Fe-4S binding domain; Region: Fer4; cl02805 273068003289 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273068003290 4Fe-4S binding domain; Region: Fer4; cl02805 273068003291 Pfam match to entry Complex1_51K, Respiratory-chain NADH dehydrogenase 51 Kd subunit, score 628.6, E-value 3.50E-185 273068003292 Pfam match to entry fer4, 4Fe-4S binding domain, score 39.5, E-value 7.40E-08 273068003293 Pfam match to entry fer4, 4Fe-4S binding domain, score 43.5, E-value 4.70E-09 273068003294 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 273068003295 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273068003296 catalytic loop [active] 273068003297 iron binding site [ion binding]; other site 273068003298 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 273068003299 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 273068003300 4Fe-4S binding domain; Region: Fer4; cl02805 273068003301 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 273068003302 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 273068003303 Pfam match to entry fer2, 2Fe-2S iron-sulfur cluster binding domains, score 39.8, E-value 6.00E-08 273068003304 Pfam match to entry Fe_hyd_lg_C, Iron only hydrogenase large subunit, C-terminal domain, score 688.6, E-value 3.00E-203 273068003305 Pfam match to entry Fe_hyd_SSU, Iron hydrogenase small subunit, score 94, E-value 2.90E-24 273068003306 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 273068003307 Maf-like protein; Region: Maf; pfam02545 273068003308 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 273068003309 active site 273068003310 dimer interface [polypeptide binding]; other site 273068003311 Pfam match to entry Maf, Maf-like protein, score 247.3, E-value 2.20E-70 273068003312 hypothetical protein; Reviewed; Region: PRK00024 273068003313 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 273068003314 MPN+ (JAMM) motif; other site 273068003315 Zinc-binding site [ion binding]; other site 273068003316 rod shape-determining protein MreB; Provisional; Region: PRK13927 273068003317 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 273068003318 ATP binding site [chemical binding]; other site 273068003319 gelsolin binding site; other site 273068003320 profilin binding site; other site 273068003321 rod shape-determining protein MreC; Provisional; Region: PRK13922 273068003322 Protein of unknown function (DUF904); Region: DUF904; cl11531 273068003323 rod shape-determining protein MreC; Region: MreC; pfam04085 273068003324 rod shape-determining protein MreD; Region: MreD; cl01087 273068003325 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273068003326 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068003327 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068003328 Pfam match to entry Transpeptidase, Penicillin binding protein transpeptidase domain, score 267.8, E-value 1.40E-76 273068003329 septum formation inhibitor; Reviewed; Region: minC; PRK00513 273068003330 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 273068003331 coenzyme A binding site [chemical binding]; other site 273068003332 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 273068003333 citrylCoA binding site [chemical binding]; other site 273068003334 septum site-determining protein MinD; Region: minD_bact; TIGR01968 273068003335 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 273068003336 Switch I; other site 273068003337 Switch II; other site 273068003338 Pfam match to entry ParA, ParA family ATPase, score 81.5, E-value 1.70E-20 273068003339 Septum formation topological specificity factor MinE; Region: MinE; cl00538 273068003340 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 273068003341 Pfam match to entry FTSW_RODA_SPOVE, Cell cycle protein, score 424.7, E-value 8.50E-124 273068003342 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 273068003343 active site 273068003344 dimer interfaces [polypeptide binding]; other site 273068003345 catalytic residues [active] 273068003346 Pfam match to entry MGS, MGS-like domain, score 85.3, E-value 1.20E-21 273068003347 Peptidase family M23; Region: Peptidase_M23; pfam01551 273068003348 Pfam match to entry Peptidase_M37, Peptidase family M23/M37, score 121.3, E-value 1.80E-32 273068003349 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 273068003350 active site 273068003351 putative substrate binding region [chemical binding]; other site 273068003352 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 273068003353 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 273068003354 B12 binding site [chemical binding]; other site 273068003355 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068003356 FeS/SAM binding site; other site 273068003357 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 273068003358 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 273068003359 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 273068003360 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 273068003361 homodimer interface [polypeptide binding]; other site 273068003362 oligonucleotide binding site [chemical binding]; other site 273068003363 Pfam match to entry S1, S1 RNA binding domain, score 36.7, E-value 1.50E-08 273068003364 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 273068003365 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 273068003366 Pfam match to entry Ribosomal_L21p, Ribosomal prokaryotic L21 protein, score 173.1, E-value 4.60E-48 273068003367 Protein of unknown function (DUF464); Region: DUF464; cl01080 273068003368 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 273068003369 Pfam match to entry Ribosomal_L27, Ribosomal L27 protein, score 192.5, E-value 6.60E-54 273068003370 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 273068003371 GTPase CgtA; Reviewed; Region: obgE; PRK12297 273068003372 GTP1/OBG; Region: GTP1_OBG; pfam01018 273068003373 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 273068003374 G1 box; other site 273068003375 GTP/Mg2+ binding site [chemical binding]; other site 273068003376 Switch I region; other site 273068003377 G2 box; other site 273068003378 G3 box; other site 273068003379 Switch II region; other site 273068003380 G4 box; other site 273068003381 G5 box; other site 273068003382 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 273068003383 Pfam match to entry GTP1_OBG, GTP1/OBG family, score 399.7, E-value 2.70E-116 273068003384 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 273068003385 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 273068003386 active site 273068003387 (T/H)XGH motif; other site 273068003388 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 273068003389 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068003390 Pfam match to entry HD, HD domain, score 95.1, E-value 1.40E-24 273068003391 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 273068003392 Oligomerisation domain; Region: Oligomerisation; cl00519 273068003393 Pfam match to entry DUF143, Domain of unknown function DUF143, score 142.9, E-value 5.50E-39 273068003394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 273068003395 YheO-like PAS domain; Region: PAS_6; pfam08348 273068003396 Helix-turn-helix domains; Region: HTH; cl00088 273068003397 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 273068003398 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068003399 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 273068003400 Pfam match to entry Octopine_DH_N, NAD/NADP octopine/nopaline dehydrogenase, NAD binding domain, score 93.4, E-value 4.70E-24 273068003401 Pfam match to entry Octopine_DH, NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain, score 140.9, E-value 2.20E-38 273068003402 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 273068003403 B12 binding site [chemical binding]; other site 273068003404 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 273068003405 substrate binding site [chemical binding]; other site 273068003406 B12 cofactor binding site [chemical binding]; other site 273068003407 heterodimer (sigma-epsilon) interface [polypeptide binding]; other site 273068003408 homodimer (epsilon-epsilon) interface [polypeptide binding]; other site 273068003409 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 273068003410 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068003411 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 273068003412 Pfam match to entry Peptidase_S11, D-alanyl-D-alanine carboxypeptidase, score 299, E-value 5.90E-86 273068003413 SLBB domain; Region: SLBB; pfam10531 273068003414 comEA protein; Region: comE; TIGR01259 273068003415 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 273068003416 Pfam match to entry HHH, Helix-hairpin-helix motif., score 39, E-value 1.00E-07 273068003417 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 273068003418 tetramer interfaces [polypeptide binding]; other site 273068003419 binuclear metal-binding site [ion binding]; other site 273068003420 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 273068003421 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273068003422 active site 273068003423 HIGH motif; other site 273068003424 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273068003425 active site 273068003426 KMSKS motif; other site 273068003427 Pfam match to entry tRNA-synt_1c, tRNA synthetases class I (E and Q), score 602.7, E-value 2.10E-177 273068003428 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 273068003429 4Fe-4S binding domain; Region: Fer4; cl02805 273068003430 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273068003431 4Fe-4S binding domain; Region: Fer4; cl02805 273068003432 Pfam match to entry fer4, 4Fe-4S binding domain, score 34.4, E-value 2.70E-06 273068003433 Pfam match to entry fer4, 4Fe-4S binding domain, score 44.6, E-value 2.20E-09 273068003434 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 273068003435 homodimer interface [polypeptide binding]; other site 273068003436 substrate-cofactor binding pocket; other site 273068003437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068003438 catalytic residue [active] 273068003439 Pfam match to entry aminotran_4, Aminotransferase class IV, score 367.4, E-value 1.50E-106 273068003440 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 273068003441 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 273068003442 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 273068003443 Pfam match to entry tRNA-synt_2c, tRNA synthetases class II (A), score 100, E-value 2.40E-28 273068003444 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 273068003445 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl01942 273068003446 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068003447 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068003448 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 273068003449 Competence protein; Region: Competence; cl00471 273068003450 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068003451 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 273068003452 DNA polymerase III, delta subunit; Region: holA; TIGR01128 273068003453 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 273068003454 Pfam match to entry Ribosomal_S20p, Ribosomal protein S20, score 127.2, E-value 3.00E-34 273068003455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068003456 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068003457 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068003458 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068003459 Membrane protein of unknown function; Region: DUF360; cl00850 273068003460 Germination protease; Region: Peptidase_A25; cl04057 273068003461 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 273068003462 stage II sporulation protein P; Region: spore_II_P; TIGR02867 273068003463 Sulfatase; Region: Sulfatase; cl10460 273068003464 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 273068003465 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 273068003466 Pfam match to entry Glycos_transf_1, Glycosyl transferases group 1, score 186.1, E-value 5.70E-52 273068003467 GTP-binding protein LepA; Provisional; Region: PRK05433 273068003468 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 273068003469 G1 box; other site 273068003470 putative GEF interaction site [polypeptide binding]; other site 273068003471 GTP/Mg2+ binding site [chemical binding]; other site 273068003472 Switch I region; other site 273068003473 G2 box; other site 273068003474 G3 box; other site 273068003475 Switch II region; other site 273068003476 G4 box; other site 273068003477 G5 box; other site 273068003478 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 273068003479 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 273068003480 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 273068003481 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 413.1, E-value 2.60E-120 273068003482 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 273068003483 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068003484 FeS/SAM binding site; other site 273068003485 HemN C-terminal region; Region: HemN_C; pfam06969 273068003486 Pfam match to entry Coprogen_an_ox, Oxygen-independent Coproporphyrinogen, score -3.6, E-value 3.80E-14 273068003487 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 273068003488 Helix-turn-helix domains; Region: HTH; cl00088 273068003489 HrcA protein C terminal domain; Region: HrcA; pfam01628 273068003490 Pfam match to entry HrcA, HrcA protein, score 346.9, E-value 2.30E-100 273068003491 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 273068003492 dimer interface [polypeptide binding]; other site 273068003493 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 273068003494 Pfam match to entry GrpE, GrpE, score 208.5, E-value 9.90E-59 273068003495 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 273068003496 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 273068003497 ATP binding site [chemical binding]; other site 273068003498 profilin binding site; other site 273068003499 Pfam match to entry HSP70, Hsp70 protein, score 1343.8, E-value 0 273068003500 chaperone protein DnaJ; Provisional; Region: PRK14277 273068003501 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 273068003502 HSP70 interaction site [polypeptide binding]; other site 273068003503 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 273068003504 substrate binding site [polypeptide binding]; other site 273068003505 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 273068003506 Zn binding sites [ion binding]; other site 273068003507 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 273068003508 dimer interface [polypeptide binding]; other site 273068003509 Pfam match to entry DnaJ, DnaJ domain, score 160.3, E-value 3.30E-44 273068003510 Pfam match to entry DnaJ_CXXCXGXG, DnaJ central domain (4 repeats), score 132.5, E-value 7.60E-36 273068003511 Pfam match to entry DnaJ_C, DnaJ C terminal region, score 244.8, E-value 1.20E-69 273068003512 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 273068003513 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068003514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068003515 S-adenosylmethionine binding site [chemical binding]; other site 273068003516 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 273068003517 RNA methyltransferase, RsmE family; Region: TIGR00046 273068003518 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 273068003519 Ferritin-like domain; Region: Ferritin; pfam00210 273068003520 ferroxidase diiron center [ion binding]; other site 273068003521 Pfam match to entry ferritin, Ferritin, score 101.4, E-value 3.30E-29 273068003522 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 273068003523 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 273068003524 TPP-binding site [chemical binding]; other site 273068003525 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 273068003526 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 273068003527 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 273068003528 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273068003529 dimer interface [polypeptide binding]; other site 273068003530 PYR/PP interface [polypeptide binding]; other site 273068003531 TPP binding site [chemical binding]; other site 273068003532 substrate binding site [chemical binding]; other site 273068003533 Pfam match to entry POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 254.8, E-value 1.20E-72 273068003534 Pfam match to entry POR, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 46.4, E-value 6.20E-10 273068003535 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 273068003536 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 273068003537 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068003538 FeS/SAM binding site; other site 273068003539 Pfam match to entry UPF0004, Uncharacterized protein family UPF0004, score 144.7, E-value 1.60E-39 273068003540 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 273068003541 nucleotide binding site/active site [active] 273068003542 HIT family signature motif; other site 273068003543 catalytic residue [active] 273068003544 Pfam match to entry HIT, HIT family, score 207.4, E-value 2.10E-58 273068003545 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 273068003546 Pfam match to entry Ribosomal_S21, Ribosomal protein S21, score 117.4, E-value 2.70E-31 273068003547 GatB domain; Region: GatB_Yqey; cl11497 273068003548 Pfam match to entry DUF186, Uncharacterized protein, YqeY family COG1610, score 147.3, E-value 2.60E-40 273068003549 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 273068003550 active site 273068003551 homotetramer interface [polypeptide binding]; other site 273068003552 homodimer interface [polypeptide binding]; other site 273068003553 Pfam match to entry Asparaginase, Asparaginase, score 275.5, E-value 6.90E-79 273068003554 YabP family; Region: YabP; cl06766 273068003555 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 273068003556 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 273068003557 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068003558 Pfam match to entry PhoH, PhoH-like protein, score 588.6, E-value 3.70E-173 273068003559 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 273068003560 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 273068003561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068003562 Zn2+ binding site [ion binding]; other site 273068003563 Mg2+ binding site [ion binding]; other site 273068003564 Pfam match to entry HD, HD domain, score 99.3, E-value 7.80E-26 273068003565 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 273068003566 Pfam match to entry UPF0054, Uncharacterized protein family UPF0054, score 155.5, E-value 9.30E-43 273068003567 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 273068003568 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 273068003569 active site 273068003570 Pfam match to entry DAGK_prokar, Prokaryotic diacylglycerol kinase, score 112.9, E-value 6.00E-30 273068003571 GTPase Era; Reviewed; Region: era; PRK00089 273068003572 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 273068003573 G1 box; other site 273068003574 GTP/Mg2+ binding site [chemical binding]; other site 273068003575 Switch I region; other site 273068003576 G2 box; other site 273068003577 Switch II region; other site 273068003578 G3 box; other site 273068003579 G4 box; other site 273068003580 G5 box; other site 273068003581 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 273068003582 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 273068003583 intersubunit interface [polypeptide binding]; other site 273068003584 active site 273068003585 catalytic residue [active] 273068003586 Pfam match to entry DeoC, Deoxyribose-phosphate aldolase, score 362, E-value 6.20E-105 273068003587 Recombination protein O N terminal; Region: RecO_N; pfam11967 273068003588 DNA repair protein RecO; Region: reco; TIGR00613 273068003589 Recombination protein O C terminal; Region: RecO_C; pfam02565 273068003590 Pfam match to entry RecO, Recombination protein O, score 97.7, E-value 2.30E-25 273068003591 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 273068003592 glycyl-tRNA synthetase; Provisional; Region: PRK04173 273068003593 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 273068003594 motif 1; other site 273068003595 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 273068003596 active site 273068003597 motif 2; other site 273068003598 motif 3; other site 273068003599 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 273068003600 anticodon binding site; other site 273068003601 Pfam match to entry tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 34.3, E-value 2.80E-06 273068003602 Helix-turn-helix domains; Region: HTH; cl00088 273068003603 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 273068003604 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 273068003605 pyruvate phosphate dikinase; Provisional; Region: PRK09279 273068003606 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 273068003607 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 273068003608 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 273068003609 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 273068003610 Pfam match to entry PPDK_N_term, Pyruvate phosphate dikinase, PEP/pyruvate binding domain, score 652, E-value 3.10E-192 273068003611 Pfam match to entry PEP-utilizers, PEP-utilizing enzyme, mobile domain, score 179.2, E-value 6.70E-50 273068003612 Pfam match to entry PEP-utilizers_C, PEP-utilizing enzyme, TIM barrel domain, score 558.2, E-value 5.30E-164 273068003613 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068003614 Pfam match to entry HD, HD domain, score 47.5, E-value 3.00E-10 273068003615 ribonuclease R; Region: RNase_R; TIGR02063 273068003616 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273068003617 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273068003618 RNB domain; Region: RNB; pfam00773 273068003619 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 273068003620 RNA binding site [nucleotide binding]; other site 273068003621 Pfam match to entry RNB, RNB-like protein, score 498.6, E-value 4.90E-146 273068003622 Pfam match to entry S1, S1 RNA binding domain, score 55.1, E-value 1.30E-13 273068003623 KaiC domain protein, Ph0284 family; Region: thermo_KaiC_1; TIGR03877 273068003624 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068003625 Walker A motif; other site 273068003626 ATP binding site [chemical binding]; other site 273068003627 Walker B motif; other site 273068003628 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 273068003629 SmpB-tmRNA interface; other site 273068003630 Pfam match to entry SmpB, SmpB protein, score 159.7, E-value 5.00E-44 273068003631 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 273068003632 proposed catalytic triad [active] 273068003633 conserved cys residue [active] 273068003634 Pfam match to entry ThiJ, ThiJ/PfpI family, score 193.2, E-value 4.10E-54 273068003635 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 273068003636 Helix-turn-helix domains; Region: HTH; cl00088 273068003637 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 273068003638 putative dimerization interface [polypeptide binding]; other site 273068003639 Pfam match to entry HTH_1, Bacterial regulatory helix-turn-helix protein, lysR family, score 171, E-value 2.00E-47 273068003640 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 273068003641 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 273068003642 active site 273068003643 FMN binding site [chemical binding]; other site 273068003644 substrate binding site [chemical binding]; other site 273068003645 putative catalytic residue [active] 273068003646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068003647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068003648 Pfam match to entry oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase family, score 259.1, E-value 6.10E-74 273068003649 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 127.3, E-value 2.70E-34 273068003650 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 273068003651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068003652 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 273068003653 4Fe-4S binding domain; Region: Fer4; cl02805 273068003654 Pfam match to entry fer4, 4Fe-4S binding domain, score 34.3, E-value 2.70E-06 273068003655 Peptidase family M48; Region: Peptidase_M48; cl12018 273068003656 Pfam match to entry Peptidase_M48, Peptidase family M48, score 123.1, E-value 5.20E-33 273068003657 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 273068003658 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 273068003659 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068003660 FeS/SAM binding site; other site 273068003661 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 273068003662 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 273068003663 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 273068003664 active site 273068003665 catalytic site [active] 273068003666 metal binding site [ion binding]; metal-binding site 273068003667 dimer interface [polypeptide binding]; other site 273068003668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068003669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273068003670 putative substrate translocation pore; other site 273068003671 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 273068003672 putative ADP-ribose binding site [chemical binding]; other site 273068003673 putative active site [active] 273068003674 Pfam match to entry A1pp, Appr-1'-p processing enzyme family, score 190.3, E-value 3.10E-53 273068003675 Bacitracin resistance protein BacA; Region: BacA; cl00858 273068003676 Pfam match to entry BacA, Bacitracin resistance protein BacA, score 128.9, E-value 9.60E-35 273068003677 small acid-soluble spore protein SspI; Provisional; Region: PRK02955; cl07940 273068003678 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 273068003679 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068003680 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 273068003681 Pfam match to entry lactamase_B, Metallo-beta-lactamase superfamily, score 119.9, E-value 4.80E-32 273068003682 Low molecular weight phosphatase family; Region: LMWPc; cd00115 273068003683 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 273068003684 active site 273068003685 Pfam match to entry LMWPc, Low molecular weight phosphotyrosine protein phosphatase, score 147.9, E-value 1.80E-40 273068003686 Exopolysaccharide biosynthesis protein related to N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: EpsL; COG4632 273068003687 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 273068003688 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 273068003689 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 273068003690 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 273068003691 Pfam match to entry G6PD, Glucose-6-phosphate dehydrogenase, NAD binding domain, score 206.3, E-value 8.00E-76 273068003692 Pfam match to entry G6PD_C, Glucose-6-phosphate dehydrogenase, C-terminal domain, score 486.8, E-value 1.80E-142 273068003693 Putative cyclase; Region: Cyclase; cl00814 273068003694 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 273068003695 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 273068003696 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 273068003697 putative L-serine binding site [chemical binding]; other site 273068003698 Pfam match to entry ACT, ACT domain, score 43.5, E-value 4.60E-09 273068003699 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 273068003700 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 273068003701 oligoendopeptidase F; Region: pepF; TIGR00181 273068003702 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 273068003703 active site 273068003704 Zn binding site [ion binding]; other site 273068003705 Pfam match to entry Peptidase_M3, Peptidase family M3, score 485.8, E-value 3.40E-142 273068003706 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 273068003707 active site 273068003708 dimer interface [polypeptide binding]; other site 273068003709 metal binding site [ion binding]; metal-binding site 273068003710 Pfam match to entry DHQ_synthase, 3-dehydroquinate synthase, score 492.8, E-value 2.60E-144 273068003711 prephenate dehydratase; Provisional; Region: PRK11898 273068003712 Prephenate dehydratase; Region: PDT; pfam00800 273068003713 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 273068003714 putative L-Phe binding site [chemical binding]; other site 273068003715 Pfam match to entry PDT, Prephenate dehydratase, score 196.8, E-value 3.30E-55 273068003716 Pfam match to entry ACT, ACT domain, score 54.7, E-value 2.00E-12 273068003717 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 273068003718 NeuB family; Region: NeuB; cl00496 273068003719 Pfam match to entry DAHP_synth_1, DAHP synthetase I family, score 413.4, E-value 2.10E-120 273068003720 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 273068003721 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068003722 Pfam match to entry PDH, Prephenate dehydrogenase, score 272.9, E-value 4.30E-78 273068003723 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 273068003724 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 273068003725 hinge; other site 273068003726 active site 273068003727 Pfam match to entry EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 562.6, E-value 2.60E-165 273068003728 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 273068003729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068003730 active site 273068003731 phosphorylation site [posttranslational modification] 273068003732 intermolecular recognition site; other site 273068003733 dimerization interface [polypeptide binding]; other site 273068003734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273068003735 DNA binding site [nucleotide binding] 273068003736 Pfam match to entry response_reg, Response regulator receiver domain, score 142, E-value 1.00E-38 273068003737 Pfam match to entry trans_reg_C, Transcriptional regulatory protein, C terminal, score 107, E-value 1.00E-30 273068003738 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 273068003739 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068003740 dimerization interface [polypeptide binding]; other site 273068003741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068003742 dimer interface [polypeptide binding]; other site 273068003743 phosphorylation site [posttranslational modification] 273068003744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068003745 ATP binding site [chemical binding]; other site 273068003746 Mg2+ binding site [ion binding]; other site 273068003747 G-X-G motif; other site 273068003748 Pfam match to entry HAMP, HAMP domain, score 43.9, E-value 3.70E-09 273068003749 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 69.8, E-value 5.60E-17 273068003750 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 158.1, E-value 1.50E-43 273068003751 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068003752 putative peptidoglycan binding site; other site 273068003753 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 273068003754 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068003755 putative peptidoglycan binding site; other site 273068003756 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 273068003757 Pfam match to entry LysM, LysM domain, score 81.9, E-value 1.40E-20 273068003758 Pfam match to entry LysM, LysM domain, score 69, E-value 9.90E-17 273068003759 Predicted membrane protein [Function unknown]; Region: COG2119 273068003760 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 273068003761 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 273068003762 Pfam match to entry UPF0016, Uncharacterized protein family UPF0016, score 61.3, E-value 2.10E-14 273068003763 Pfam match to entry UPF0016, Uncharacterized protein family UPF0016, score 43.8, E-value 3.90E-09 273068003764 Creatinine amidohydrolase; Region: Creatininase; cl00618 273068003765 Pfam match to entry Creatininase, Creatinine amidohydrolase, score 68.4, E-value 1.60E-16 273068003766 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 273068003767 putative trimer interface [polypeptide binding]; other site 273068003768 putative CoA binding site [chemical binding]; other site 273068003769 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 273068003770 active site 273068003771 trimer interface [polypeptide binding]; other site 273068003772 allosteric site; other site 273068003773 active site lid [active] 273068003774 hexamer (dimer of trimers) interface [polypeptide binding]; other site 273068003775 Pfam match to entry Glucosamine_iso, Glucosamine-6-phosphate isomerases/6-phosphogluconolactonases, score 334.3, E-value 1.40E-96 273068003776 Acyl-protein synthetase, LuxE; Region: LuxE; cl15695 273068003777 LysE type translocator; Region: LysE; cl00565 273068003778 Pfam match to entry DsbD, Cytochrome C biogenesis protein transmembrane region, score 211.8, E-value 1.00E-59 273068003779 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 273068003780 catalytic residues [active] 273068003781 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 273068003782 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 273068003783 homodimer interface [polypeptide binding]; other site 273068003784 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068003785 catalytic residue [active] 273068003786 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 273068003787 Pfam match to entry OKR_DC_1, Orn/Lys/Arg decarboxylase, score 529, E-value 3.40E-155 273068003788 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 273068003789 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 273068003790 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 273068003791 catalytic loop [active] 273068003792 iron binding site [ion binding]; other site 273068003793 Pfam match to entry fer2, 2Fe-2S iron-sulfur cluster binding domains, score 38, E-value 2.20E-07 273068003794 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068003795 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068003796 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068003797 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 273068003798 Helix-turn-helix domains; Region: HTH; cl00088 273068003799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068003800 Zn2+ binding site [ion binding]; other site 273068003801 Mg2+ binding site [ion binding]; other site 273068003802 Pfam match to entry HD, HD domain, score 71.5, E-value 1.80E-17 273068003803 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273068003804 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 273068003805 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 273068003806 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 116.4, E-value 7.60E-32 273068003807 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 92.3, E-value 6.00E-25 273068003808 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 273068003809 putative CheA interaction surface; other site 273068003810 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 273068003811 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 273068003812 putative CheA interaction surface; other site 273068003813 Pfam match to entry CheW, CheW-like domain, score 146.5, E-value 4.80E-40 273068003814 Pfam match to entry CheW, CheW-like domain, score 145.5, E-value 9.10E-40 273068003815 Pfam match to entry CheW, CheW-like domain, score 159.4, E-value 6.30E-44 273068003816 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 273068003817 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068003818 active site 273068003819 phosphorylation site [posttranslational modification] 273068003820 intermolecular recognition site; other site 273068003821 dimerization interface [polypeptide binding]; other site 273068003822 CheB methylesterase; Region: CheB_methylest; pfam01339 273068003823 Pfam match to entry response_reg, Response regulator receiver domain, score 94.6, E-value 2.00E-24 273068003824 Pfam match to entry CheB_methylest, CheB methylesterase, score 246.7, E-value 3.20E-70 273068003825 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 273068003826 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 273068003827 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 273068003828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068003829 S-adenosylmethionine binding site [chemical binding]; other site 273068003830 Pfam match to entry CheR, CheR methyltransferase, score 306.3, E-value 3.60E-88 273068003831 Response regulator receiver domain; Region: Response_reg; pfam00072 273068003832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068003833 active site 273068003834 phosphorylation site [posttranslational modification] 273068003835 intermolecular recognition site; other site 273068003836 dimerization interface [polypeptide binding]; other site 273068003837 Pfam match to entry response_reg, Response regulator receiver domain, score 118.4, E-value 1.30E-31 273068003838 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 273068003839 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068003840 ATP binding site [chemical binding]; other site 273068003841 Mg2+ binding site [ion binding]; other site 273068003842 G-X-G motif; other site 273068003843 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 273068003844 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 95.1, E-value 6.10E-25 273068003845 Pfam match to entry CheW, CheW-like domain, score 45.1, E-value 1.50E-09 273068003846 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068003847 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068003848 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068003849 Pfam match to entry Transposase_9, Transposase, score 52.8, E-value 7.50E-12 273068003850 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 87.4, E-value 3.00E-22 273068003851 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 273068003852 Pfam match to entry STAS, STAS domain, score 59.2, E-value 8.70E-14 273068003853 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 273068003854 Pfam match to entry STAS, STAS domain, score 38.7, E-value 1.40E-07 273068003855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068003856 ATP binding site [chemical binding]; other site 273068003857 Mg2+ binding site [ion binding]; other site 273068003858 G-X-G motif; other site 273068003859 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 30.7, E-value 4.20E-07 273068003860 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 273068003861 ATP binding site [chemical binding]; other site 273068003862 Mg2+ binding site [ion binding]; other site 273068003863 G-X-G motif; other site 273068003864 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 273068003865 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 273068003866 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273068003867 metal binding site [ion binding]; metal-binding site 273068003868 active site 273068003869 I-site; other site 273068003870 Pfam match to entry GGDEF, GGDEF domain, score 133.9, E-value 2.90E-36 273068003871 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 273068003872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068003873 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068003874 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068003875 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068003876 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 273068003877 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068003878 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 273068003879 Pfam match to entry HAMP, HAMP domain, score 35.2, E-value 1.50E-06 273068003880 Phd_YefM; Region: PhdYeFM; cl09153 273068003881 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 273068003882 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 273068003883 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 273068003884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068003885 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 273068003886 active site 273068003887 dimerization interface [polypeptide binding]; other site 273068003888 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 273068003889 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 273068003890 active site 273068003891 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 273068003892 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 273068003893 Sporulation and spore germination; Region: Germane; cl11253 273068003894 biotin synthase; Provisional; Region: PRK07094 273068003895 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068003896 FeS/SAM binding site; other site 273068003897 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 273068003898 Pfam match to entry Biotin_synth, Biotin synthase, score -45.4, E-value 3.90E-12 273068003899 Transposase domain (DUF772); Region: DUF772; cl12084 273068003900 Transposase domain (DUF772); Region: DUF772; cl15789 273068003901 Helix-turn-helix domains; Region: HTH; cl00088 273068003902 BlaR1 peptidase M56; Region: Peptidase_M56; cl15829 273068003903 PAS domain S-box; Region: sensory_box; TIGR00229 273068003904 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273068003905 putative active site [active] 273068003906 heme pocket [chemical binding]; other site 273068003907 cell division protein MukB; Provisional; Region: mukB; PRK04863 273068003908 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273068003909 PAS fold; Region: PAS_3; pfam08447 273068003910 putative active site [active] 273068003911 heme pocket [chemical binding]; other site 273068003912 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273068003913 metal binding site [ion binding]; metal-binding site 273068003914 active site 273068003915 I-site; other site 273068003916 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 273068003917 Pfam match to entry EAL, Domain of unknown function 2, score 259.4, E-value 4.80E-74 273068003918 Pfam match to entry GGDEF, GGDEF domain, score 226.5, E-value 3.90E-64 273068003919 Pfam match to entry PAC, PAC motif, score 42.7, E-value 1.30E-10 273068003920 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068003921 Protein of unknown function (DUF342); Region: DUF342; pfam03961 273068003922 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 273068003923 L-Aminopeptidase D-amidase/D-esterase (DmpA) family; DmpA catalyzes the release of N-terminal D and L amino acids from peptide susbtrates. DmpA is synthesized as a single polypeptide precursor, which is autocatalytically cleaved to the active...; Region: DmpA; cd02253 273068003924 homodimer interface [polypeptide binding]; other site 273068003925 homotetramer interface [polypeptide binding]; other site 273068003926 active site pocket [active] 273068003927 cleavage site 273068003928 S-Ribosylhomocysteinase (LuxS); Region: LuxS; cl00802 273068003929 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 273068003930 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 273068003931 putative active site [active] 273068003932 putative metal binding site [ion binding]; other site 273068003933 4Fe-4S binding domain; Region: Fer4_5; pfam12801 273068003934 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 273068003935 Response regulator receiver domain; Region: Response_reg; pfam00072 273068003936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068003937 active site 273068003938 phosphorylation site [posttranslational modification] 273068003939 intermolecular recognition site; other site 273068003940 dimerization interface [polypeptide binding]; other site 273068003941 PAS domain S-box; Region: sensory_box; TIGR00229 273068003942 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068003943 PAS domain S-box; Region: sensory_box; TIGR00229 273068003944 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273068003945 putative active site [active] 273068003946 heme pocket [chemical binding]; other site 273068003947 PAS domain S-box; Region: sensory_box; TIGR00229 273068003948 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 273068003949 putative active site [active] 273068003950 heme pocket [chemical binding]; other site 273068003951 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273068003952 metal binding site [ion binding]; metal-binding site 273068003953 active site 273068003954 I-site; other site 273068003955 Pfam match to entry response_reg, Response regulator receiver domain, score 92.6, E-value 8.00E-24 273068003956 Pfam match to entry PAS, PAS domain, score 22.6, E-value 0.00012 273068003957 Pfam match to entry PAS, PAS domain, score 62.6, E-value 9.60E-16 273068003958 Pfam match to entry PAC, PAC motif, score 30.9, E-value 3.60E-07 273068003959 Pfam match to entry GGDEF, GGDEF domain, score 226.7, E-value 3.30E-64 273068003960 Response regulator receiver domain; Region: Response_reg; pfam00072 273068003961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068003962 active site 273068003963 phosphorylation site [posttranslational modification] 273068003964 intermolecular recognition site; other site 273068003965 dimerization interface [polypeptide binding]; other site 273068003966 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 273068003967 Pfam match to entry response_reg, Response regulator receiver domain, score 137.9, E-value 1.80E-37 273068003968 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 273068003969 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068003970 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068003971 Pfam match to entry Transposase_9, Transposase, score 33.5, E-value 4.80E-06 273068003972 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 97.2, E-value 3.20E-25 273068003973 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 273068003974 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068003975 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068003976 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 273068003977 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 273068003978 Pfam match to entry GIDA, Glucose inhibited division protein A, score 1241.5, E-value 0 273068003979 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 273068003980 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 273068003981 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 273068003982 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 273068003983 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 273068003984 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 273068003985 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068003986 Pfam match to entry BcrAD_BadFG, BadF/BadG/BcrA/BcrD ATPase family, score 336.5, E-value 3.00E-97 273068003987 Predicted site-specific integrase-resolvase [DNA replication, recombination, and repair]; Region: COG2452 273068003988 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 273068003989 DNA binding residues [nucleotide binding] 273068003990 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068003991 catalytic residues [active] 273068003992 catalytic nucleophile [active] 273068003993 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 29.4, E-value 9.00E-08 273068003994 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 273068003995 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 273068003996 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 273068003997 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 273068003998 Pfam match to entry Hydantoinase_A, Hydantoinase/oxoprolinase, score 52.5, E-value 3.30E-14 273068003999 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 273068004000 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 273068004001 Pfam match to entry Hist_deacetyl, Histone deacetylase family, score 245.6, E-value 6.80E-70 273068004002 Transposase [DNA replication, recombination, and repair]; Region: COG5421 273068004003 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 273068004004 homodimer interface [polypeptide binding]; other site 273068004005 putative active site [active] 273068004006 catalytic site [active] 273068004007 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068004008 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068004009 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068004010 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068004011 Sporulation protein and related proteins [Cell division and chromosome partitioning]; Region: SpoIID; COG2385 273068004012 Stage II sporulation protein; Region: SpoIID; pfam08486 273068004013 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 51.5, E-value 1.90E-11 273068004014 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 71.3, E-value 2.10E-17 273068004015 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 69.2, E-value 8.70E-17 273068004016 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 59.2, E-value 9.20E-14 273068004017 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 273068004018 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 273068004019 G1 box; other site 273068004020 GTP/Mg2+ binding site [chemical binding]; other site 273068004021 Switch I region; other site 273068004022 G2 box; other site 273068004023 G3 box; other site 273068004024 Switch II region; other site 273068004025 G4 box; other site 273068004026 G5 box; other site 273068004027 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 273068004028 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 273068004029 active site 273068004030 Ap6A binding site [chemical binding]; other site 273068004031 nudix motif; other site 273068004032 metal binding site [ion binding]; metal-binding site 273068004033 Pfam match to entry mutT, MutT-like domain, score 39.7, E-value 6.50E-08 273068004034 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 273068004035 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 273068004036 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 273068004037 Pfam match to entry UPF0029, Uncharacterized protein family UPF0029, score 220.9, E-value 1.90E-62 273068004038 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068004039 Pfam match to entry DUF184, Uncharacterized ACR, COG1832, score 83.9, E-value 3.20E-21 273068004040 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 273068004041 Pfam match to entry DUF81, Domain of unknown function DUF81, score 53.9, E-value 3.10E-14 273068004042 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 273068004043 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 273068004044 dimer interface [polypeptide binding]; other site 273068004045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068004046 catalytic residue [active] 273068004047 Pfam match to entry PALP, Pyridoxal-phosphate dependent enzyme, score 443.7, E-value 1.60E-129 273068004048 Transcriptional regulator; Region: Transcrip_reg; cl00361 273068004049 Pfam match to entry DUF28, Domain of unknown function DUF28, score 421.6, E-value 7.40E-123 273068004050 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 273068004051 Pfam match to entry CheW, CheW-like domain, score 159, E-value 7.90E-44 273068004052 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068004053 non-specific DNA binding site [nucleotide binding]; other site 273068004054 salt bridge; other site 273068004055 sequence-specific DNA binding site [nucleotide binding]; other site 273068004056 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068004057 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068004058 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068004059 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273068004060 binding surface 273068004061 TPR motif; other site 273068004062 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068004063 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068004064 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068004065 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004066 Walker A/P-loop; other site 273068004067 ATP binding site [chemical binding]; other site 273068004068 Q-loop/lid; other site 273068004069 ABC transporter signature motif; other site 273068004070 Walker B; other site 273068004071 D-loop; other site 273068004072 H-loop/switch region; other site 273068004073 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 75.6, E-value 1.00E-18 273068004074 Pfam match to entry ABC_tran, ABC transporter, score 179.7, E-value 4.70E-50 273068004075 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273068004076 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004077 Walker A/P-loop; other site 273068004078 ATP binding site [chemical binding]; other site 273068004079 Q-loop/lid; other site 273068004080 ABC transporter signature motif; other site 273068004081 Walker B; other site 273068004082 D-loop; other site 273068004083 H-loop/switch region; other site 273068004084 Pfam match to entry ABC_tran, ABC transporter, score 160.6, E-value 2.60E-44 273068004085 ABC-2 type transporter; Region: ABC2_membrane; cl11417 273068004086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 273068004087 TPR motif; other site 273068004088 binding surface 273068004089 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068004090 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068004091 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 273068004092 active site residue [active] 273068004093 Pfam match to entry Rhodanese, Rhodanese-like domain, score 48.7, E-value 1.30E-10 273068004094 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 273068004095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004096 FeS/SAM binding site; other site 273068004097 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068004098 Pfam match to entry MoaA_NifB_PqqE, moaA / nifB / pqqE family, score 36.2, E-value 2.00E-07 273068004099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068004100 putative substrate translocation pore; other site 273068004101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068004102 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068004103 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068004104 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068004105 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 273068004106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273068004107 Integrase core domain; Region: rve; cl01316 273068004108 Pfam match to entry rve, Integrase core domain, score 30.7, E-value 1.00E-07 273068004109 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004110 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 273068004111 FeS/SAM binding site; other site 273068004112 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068004113 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 273068004114 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 273068004115 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 273068004116 Helix-turn-helix domains; Region: HTH; cl00088 273068004117 Integrase core domain; Region: rve; cl01316 273068004118 Pfam match to entry rve, Integrase core domain, score 66.6, E-value 4.40E-18 273068004119 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004120 FeS/SAM binding site; other site 273068004121 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068004122 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 273068004123 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 273068004124 Walker A/P-loop; other site 273068004125 ATP binding site [chemical binding]; other site 273068004126 Q-loop/lid; other site 273068004127 ABC transporter signature motif; other site 273068004128 Walker B; other site 273068004129 D-loop; other site 273068004130 H-loop/switch region; other site 273068004131 Pfam match to entry ABC_tran, ABC transporter, score 135.1, E-value 1.30E-36 273068004132 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 273068004133 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 273068004134 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 273068004135 Protein of unknown function (DUF990); Region: DUF990; cl01496 273068004136 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068004137 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068004138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004139 Walker A/P-loop; other site 273068004140 ATP binding site [chemical binding]; other site 273068004141 Q-loop/lid; other site 273068004142 ABC transporter signature motif; other site 273068004143 Walker B; other site 273068004144 D-loop; other site 273068004145 H-loop/switch region; other site 273068004146 Pfam match to entry ABC_tran, ABC transporter, score 121.4, E-value 1.70E-32 273068004147 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004148 Radical SAM superfamily; Region: Radical_SAM; pfam04055 273068004149 FeS/SAM binding site; other site 273068004150 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 273068004151 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068004152 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068004153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068004154 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068004155 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068004156 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068004157 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068004158 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068004159 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068004160 Pfam match to entry Transposase_9, Transposase, score 52.6, E-value 8.50E-12 273068004161 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 87.4, E-value 3.00E-22 273068004162 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068004163 Active site serine [active] 273068004164 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068004165 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 273068004166 active site triad [active] 273068004167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004168 ABC transporter signature motif; other site 273068004169 Walker B; other site 273068004170 D-loop; other site 273068004171 H-loop/switch region; other site 273068004172 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004173 H-loop/switch region; other site 273068004174 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273068004175 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004176 Walker A/P-loop; other site 273068004177 ATP binding site [chemical binding]; other site 273068004178 Q-loop/lid; other site 273068004179 ABC transporter signature motif; other site 273068004180 Walker B; other site 273068004181 D-loop; other site 273068004182 H-loop/switch region; other site 273068004183 Pfam match to entry ABC_tran, ABC transporter, score 160.3, E-value 3.20E-44 273068004184 ABC-2 type transporter; Region: ABC2_membrane; cl11417 273068004185 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 273068004186 active site 273068004187 putative DNA-binding cleft [nucleotide binding]; other site 273068004188 dimer interface [polypeptide binding]; other site 273068004189 Pfam match to entry RuvC, Crossover junction endodeoxyribonuclease RuvC, score 227.4, E-value 2.00E-64 273068004190 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 273068004191 RuvA N terminal domain; Region: RuvA_N; pfam01330 273068004192 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 273068004193 Pfam match to entry RuvA, RuvA N terminal domain, score 67.5, E-value 2.90E-16 273068004194 Pfam match to entry RuvA_II, RuvA central domain II, score 122.5, E-value 7.90E-33 273068004195 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 273068004196 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068004197 Walker A motif; other site 273068004198 ATP binding site [chemical binding]; other site 273068004199 Walker B motif; other site 273068004200 arginine finger; other site 273068004201 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 273068004202 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 116.9, E-value 3.90E-31 273068004203 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 273068004204 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 273068004205 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 273068004206 Pfam match to entry Queuosine_synth, Queuosine biosynthesis protein, score 370.1, E-value 2.30E-107 273068004207 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 273068004208 Pfam match to entry TGT, Queuine tRNA-ribosyltransferase, score 543.8, E-value 1.20E-159 273068004209 Preprotein translocase subunit; Region: YajC; cl00806 273068004210 Pfam match to entry DUF219, Uncharacterized secreted proteins, YajC family COG1862, score 86.8, E-value 4.30E-22 273068004211 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 273068004212 SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974 273068004213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004214 FeS/SAM binding site; other site 273068004215 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 273068004216 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 273068004217 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 273068004218 trimer interface [polypeptide binding]; other site 273068004219 putative metal binding site [ion binding]; other site 273068004220 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 273068004221 Protein export membrane protein; Region: SecD_SecF; cl14618 273068004222 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 273068004223 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 273068004224 Protein export membrane protein; Region: SecD_SecF; cl14618 273068004225 Pfam match to entry SecD_SecF, Protein export membrane protein, score 264.2, E-value 1.70E-75 273068004226 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 273068004227 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 273068004228 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 273068004229 active site 273068004230 ATP binding site [chemical binding]; other site 273068004231 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 273068004232 DHH family; Region: DHH; pfam01368 273068004233 Pfam match to entry DHH, DHH family, score 188.6, E-value 1.00E-52 273068004234 Pfam match to entry DHHA1, DHHA1 domain, score 45, E-value 1.70E-09 273068004235 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068004236 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068004237 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068004238 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 138.9, E-value 9.00E-38 273068004239 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 273068004240 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068004241 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 273068004242 synthetase active site [active] 273068004243 NTP binding site [chemical binding]; other site 273068004244 metal binding site [ion binding]; metal-binding site 273068004245 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 273068004246 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 273068004247 Pfam match to entry TGS, TGS domain, score 114.2, E-value 2.50E-30 273068004248 Pfam match to entry ACT, ACT domain, score 48.4, E-value 1.60E-10 273068004249 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 273068004250 putative active site [active] 273068004251 dimerization interface [polypeptide binding]; other site 273068004252 putative tRNAtyr binding site [nucleotide binding]; other site 273068004253 Pfam match to entry DUF154, Uncharacterized ACR, COG1490, score 219.7, E-value 4.30E-62 273068004254 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068004255 Pfam match to entry lactamase_B, Metallo-beta-lactamase superfamily, score 165, E-value 1.20E-45 273068004256 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 273068004257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 273068004258 FtsX-like permease family; Region: FtsX; pfam02687 273068004259 Pfam match to entry DUF214, Predicted permease, score 178.2, E-value 1.30E-49 273068004260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273068004261 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 273068004262 Walker A/P-loop; other site 273068004263 ATP binding site [chemical binding]; other site 273068004264 Q-loop/lid; other site 273068004265 ABC transporter signature motif; other site 273068004266 Walker B; other site 273068004267 D-loop; other site 273068004268 H-loop/switch region; other site 273068004269 Pfam match to entry ABC_tran, ABC transporter, score 204.9, E-value 1.20E-57 273068004270 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 273068004271 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 273068004272 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273068004273 Helix-turn-helix domains; Region: HTH; cl00088 273068004274 Pfam match to entry MarR, MarR family, score 90.8, E-value 2.80E-23 273068004275 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 273068004276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068004277 ATP binding site [chemical binding]; other site 273068004278 Mg2+ binding site [ion binding]; other site 273068004279 G-X-G motif; other site 273068004280 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 109.1, E-value 8.10E-29 273068004281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068004282 Response regulator receiver domain; Region: Response_reg; pfam00072 273068004283 active site 273068004284 phosphorylation site [posttranslational modification] 273068004285 intermolecular recognition site; other site 273068004286 dimerization interface [polypeptide binding]; other site 273068004287 YcbB domain; Region: YcbB; pfam08664 273068004288 Pfam match to entry response_reg, Response regulator receiver domain, score 75.7, E-value 9.70E-19 273068004289 seryl-tRNA synthetase; Provisional; Region: PRK05431 273068004290 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 273068004291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004292 FeS/SAM binding site; other site 273068004293 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 273068004294 Pfam match to entry DUF160, Uncharacterized ACR, YjeK family COG1509, score 476.2, E-value 2.60E-139 273068004295 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 273068004296 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 273068004297 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 273068004298 NAD(P) binding site [chemical binding]; other site 273068004299 Pfam match to entry GLFV_dehydrog_N, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, score 269.2, E-value 5.30E-77 273068004300 Pfam match to entry GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, score 353.3, E-value 2.60E-102 273068004301 aspartate aminotransferase; Provisional; Region: PRK05764 273068004302 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273068004303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068004304 homodimer interface [polypeptide binding]; other site 273068004305 catalytic residue [active] 273068004306 Pfam match to entry aminotran_1, Aminotransferase class-I, score 337.9, E-value 1.10E-97 273068004307 alanine racemase; Reviewed; Region: alr; PRK00053 273068004308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 273068004309 active site 273068004310 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273068004311 dimer interface [polypeptide binding]; other site 273068004312 substrate binding site [chemical binding]; other site 273068004313 catalytic residues [active] 273068004314 Pfam match to entry Ala_racemase, Alanine racemase, score 415, E-value 7.10E-121 273068004315 oxaloacetate decarboxylase; Provisional; Region: PRK12331 273068004316 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 273068004317 active site 273068004318 catalytic residues [active] 273068004319 metal binding site [ion binding]; metal-binding site 273068004320 homodimer binding site [polypeptide binding]; other site 273068004321 Pfam match to entry HMGL-like, HMGL-like, score 215.2, E-value 9.50E-61 273068004322 Pfam match to entry PYC_OADA, Conserved carboxylase domain, score 257.2, E-value 2.20E-73 273068004323 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 273068004324 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273068004325 dimer interface [polypeptide binding]; other site 273068004326 PYR/PP interface [polypeptide binding]; other site 273068004327 TPP binding site [chemical binding]; other site 273068004328 substrate binding site [chemical binding]; other site 273068004329 Pfam match to entry POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 345.1, E-value 7.90E-100 273068004330 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 273068004331 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 273068004332 TPP-binding site [chemical binding]; other site 273068004333 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 273068004334 Pfam match to entry POR, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 154.7, E-value 1.50E-42 273068004335 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273068004336 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273068004337 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273068004338 putative active site [active] 273068004339 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 273068004340 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 273068004341 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273068004342 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 273068004343 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068004344 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 273068004345 Pfam match to entry Cation_ATPase_N, Cation transporter/ATPase, N-terminus, score 70.2, E-value 4.30E-17 273068004346 Pfam match to entry E1-E2_ATPase, E1-E2 ATPase, score 363.6, E-value 2.60E-109 273068004347 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 90.5, E-value 3.30E-23 273068004348 Pfam match to entry Cation_ATPase_C, Cation transporting ATPase, C-terminus, score 44.1, E-value 3.20E-09 273068004349 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 273068004350 Pfam match to entry SDF, Sodium:dicarboxylate symporter family, score 279.1, E-value 5.70E-80 273068004351 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816 273068004352 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 273068004353 Ferredoxin [Energy production and conversion]; Region: COG1146 273068004354 Pfam match to entry fer4, 4Fe-4S binding domain, score 36.7, E-value 5.20E-07 273068004355 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 273068004356 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 273068004357 Pfam match to entry MM_CoA_mutase, Methylmalonyl-CoA mutase, score 958.2, E-value 2.10E-284 273068004358 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 273068004359 B12 binding site [chemical binding]; other site 273068004360 cobalt ligand [ion binding]; other site 273068004361 Pfam match to entry B12-binding, B12 binding domain, score 167.6, E-value 2.10E-46 273068004362 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273068004363 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 273068004364 dimer interface [polypeptide binding]; other site 273068004365 substrate binding site [chemical binding]; other site 273068004366 metal binding site [ion binding]; metal-binding site 273068004367 Pfam match to entry Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 83.3, E-value 8.50E-23 273068004368 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 273068004369 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 273068004370 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 273068004371 Pfam match to entry Carboxyl_trans, Carboxyl transferase domain, score 1052.5, E-value 0 273068004372 pyruvate carboxylase subunit B; Validated; Region: PRK09282 273068004373 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 273068004374 carboxyltransferase (CT) interaction site; other site 273068004375 biotinylation site [posttranslational modification]; other site 273068004376 Pfam match to entry biotin_lipoyl, Biotin-requiring enzyme, score 101.9, E-value 1.30E-26 273068004377 Protein of unknown function (DUF401); Region: DUF401; cl00830 273068004378 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 273068004379 Pfam match to entry Asp_Glu_race, Asp/Glu/Hydontoin racemase, score 238.2, E-value 1.20E-67 273068004380 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 273068004381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273068004382 Integrase core domain; Region: rve; cl01316 273068004383 Pfam match to entry rve, Integrase core domain, score 30.7, E-value 1.00E-07 273068004384 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068004385 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068004386 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068004387 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.10E-19 273068004388 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 273068004389 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 273068004390 dimer interface [polypeptide binding]; other site 273068004391 motif 1; other site 273068004392 active site 273068004393 motif 2; other site 273068004394 motif 3; other site 273068004395 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 273068004396 anticodon binding site; other site 273068004397 Pfam match to entry tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 179.9, E-value 4.10E-50 273068004398 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 273068004399 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 273068004400 dimer interface [polypeptide binding]; other site 273068004401 anticodon binding site; other site 273068004402 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 273068004403 homodimer interface [polypeptide binding]; other site 273068004404 motif 1; other site 273068004405 active site 273068004406 motif 2; other site 273068004407 GAD domain; Region: GAD; pfam02938 273068004408 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 273068004409 motif 3; other site 273068004410 Pfam match to entry tRNA_anti, OB-fold nucleic acid binding domain, score 59, E-value 9.90E-14 273068004411 Pfam match to entry tRNA-synt_2, tRNA synthetases class II (D, K and N), score 73.3, E-value 5.20E-18 273068004412 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 273068004413 putative homotetramer interface [polypeptide binding]; other site 273068004414 putative homodimer interface [polypeptide binding]; other site 273068004415 putative allosteric switch controlling residues; other site 273068004416 putative metal binding site [ion binding]; other site 273068004417 putative homodimer-homodimer interface [polypeptide binding]; other site 273068004418 Pfam match to entry DUF156, Uncharacterized BCR, COG1937, score 67.4, E-value 3.00E-16 273068004419 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273068004420 catalytic residues [active] 273068004421 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273068004422 catalytic residues [active] 273068004423 Pfam match to entry thiored, Thioredoxin, score 146.7, E-value 6.20E-43 273068004424 Pfam match to entry thiored, Thioredoxin, score 149.5, E-value 8.50E-44 273068004425 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 273068004426 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068004427 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 273068004428 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 273068004429 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273068004430 catalytic residue [active] 273068004431 Pfam match to entry PALP, Pyridoxal-phosphate dependent enzyme, score 114, E-value 2.90E-30 273068004432 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 273068004433 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 273068004434 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 273068004435 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 273068004436 B12 binding site [chemical binding]; other site 273068004437 cobalt ligand [ion binding]; other site 273068004438 Pfam match to entry B12-binding, B12 binding domain, score 69.3, E-value 8.00E-17 273068004439 MutL protein; Region: MutL; pfam13941 273068004440 Predicted transcriptional regulator [Transcription]; Region: COG1959 273068004441 Helix-turn-helix domains; Region: HTH; cl00088 273068004442 Pfam match to entry UPF0074, Uncharacterized protein family UPF0074, score 144, E-value 2.70E-39 273068004443 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 273068004444 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 273068004445 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 273068004446 Domain of unknown function DUF20; Region: UPF0118; cl00465 273068004447 Pfam match to entry UPF0118, Domain of unknown function DUF20, score 247.6, E-value 1.80E-70 273068004448 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068004449 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 273068004450 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 273068004451 motif 1; other site 273068004452 active site 273068004453 motif 2; other site 273068004454 motif 3; other site 273068004455 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 273068004456 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 273068004457 DHHA1 domain; Region: DHHA1; pfam02272 273068004458 Pfam match to entry tRNA-synt_2c, tRNA synthetases class II (A), score 1284.7, E-value 0 273068004459 Pfam match to entry DHHA1, DHHA1 domain, score 62.6, E-value 8.60E-15 273068004460 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 273068004461 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 273068004462 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 273068004463 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273068004464 metal binding site 2 [ion binding]; metal-binding site 273068004465 putative DNA binding helix; other site 273068004466 metal binding site 1 [ion binding]; metal-binding site 273068004467 dimer interface [polypeptide binding]; other site 273068004468 structural Zn2+ binding site [ion binding]; other site 273068004469 Pfam match to entry FUR, Ferric uptake regulator family, score 181.2, E-value 1.70E-50 273068004470 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 273068004471 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068004472 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 273068004473 Pfam match to entry lactamase_B, Metallo-beta-lactamase superfamily, score 120.2, E-value 3.90E-32 273068004474 Pfam match to entry UPF0036, Uncharacterized protein family UPF0036, score 534.4, E-value 8.00E-157 273068004475 QueT transporter; Region: QueT; cl01932 273068004476 YceG-like family; Region: YceG; pfam02618 273068004477 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 273068004478 dimerization interface [polypeptide binding]; other site 273068004479 Pfam match to entry DUF175, Uncharacterized BCR, YceG family COG1559, score 384.9, E-value 8.00E-112 273068004480 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 273068004481 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068004482 S-adenosylmethionine binding site [chemical binding]; other site 273068004483 Pfam match to entry Methyltransf_3, O-methyltransferase, score 87.7, E-value 2.30E-22 273068004484 putative protease; Provisional; Region: PRK15452 273068004485 Peptidase family U32; Region: Peptidase_U32; cl03113 273068004486 Pfam match to entry Peptidase_U32, Peptidase family U32, score 391.5, E-value 8.30E-114 273068004487 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 273068004488 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273068004489 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068004490 Pfam match to entry Transpeptidase, Penicillin binding protein transpeptidase domain, score 287.1, E-value 2.30E-82 273068004491 sporulation sigma factor SigK; Reviewed; Region: PRK05803 273068004492 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068004493 Protein-interacting V-domain of mammalian Alix and related domains; Region: V_Alix_like; cl14654 273068004494 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068004495 DNA binding residues [nucleotide binding] 273068004496 Pfam match to entry sigma70, Sigma-70 factor, score 198.7, E-value 9.00E-56 273068004497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068004498 active site 273068004499 motif I; other site 273068004500 motif II; other site 273068004501 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 273068004502 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 273068004503 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 273068004504 shikimate binding site; other site 273068004505 NAD(P) binding site [chemical binding]; other site 273068004506 Pfam match to entry Shikimate_DH, Shikimate / quinate 5-dehydrogenase, score 330.9, E-value 1.50E-95 273068004507 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 273068004508 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 273068004509 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 273068004510 Walker A motif; other site 273068004511 ATP binding site [chemical binding]; other site 273068004512 Walker B motif; other site 273068004513 Pfam match to entry GSPII_E, Bacterial type II secretion system protein, score 580.7, E-value 4.40E-172 273068004514 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 273068004515 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 273068004516 Walker A motif; other site 273068004517 ATP binding site [chemical binding]; other site 273068004518 Walker B motif; other site 273068004519 Pfam match to entry GSPII_E, Bacterial type II secretion system protein, score 171, E-value 4.20E-50 273068004520 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 273068004521 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 273068004522 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 273068004523 Pfam match to entry GSPII_F, Bacterial type II secretion system protein F domain, score 374.3, E-value 1.20E-108 273068004524 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 273068004525 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 273068004526 Pfam match to entry Peptidase_C20, Type III leader peptidase family, score 261.8, E-value 8.90E-75 273068004527 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 273068004528 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 273068004529 general secretion pathway protein I; Region: gspI; TIGR01707 273068004530 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 273068004531 PilX N-terminal; Region: PilX_N; pfam14341 273068004532 Late competence development protein ComFB; Region: ComFB; pfam10719 273068004533 ethanolamine utilization protein EutJ family protein; Region: EutJ; TIGR02529 273068004534 Cell division protein FtsA; Region: FtsA; cl11496 273068004535 Cell division protein FtsA; Region: FtsA; cl11496 273068004536 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 273068004537 Pilus assembly protein, PilO; Region: PilO; cl01234 273068004538 shikimate kinase; Provisional; Region: PRK13947 273068004539 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 273068004540 ADP binding site [chemical binding]; other site 273068004541 magnesium binding site [ion binding]; other site 273068004542 putative shikimate binding site; other site 273068004543 Pfam match to entry SKI, Shikimate kinase, score 167.3, E-value 2.60E-46 273068004544 AP endonuclease family 2; Region: AP2Ec; smart00518 273068004545 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 273068004546 Metal-binding active site; metal-binding site 273068004547 Pfam match to entry AP_endonulease2, AP endonuclease family 2, score -52.4, E-value 1.20E-07 273068004548 gamma-glutamyl kinase; Provisional; Region: PRK05429 273068004549 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 273068004550 nucleotide binding site [chemical binding]; other site 273068004551 homotetrameric interface [polypeptide binding]; other site 273068004552 putative phosphate binding site [ion binding]; other site 273068004553 putative allosteric binding site; other site 273068004554 PUA domain; Region: PUA; cl00607 273068004555 Pfam match to entry aakinase, Amino acid kinase family, score 241.4, E-value 1.30E-68 273068004556 Pfam match to entry PUA, PUA domain, score 51.2, E-value 2.30E-11 273068004557 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 273068004558 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 273068004559 putative catalytic cysteine [active] 273068004560 Pfam match to entry aldedh, Aldehyde dehydrogenase family, score -151.3, E-value 9.50E-08 273068004561 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 273068004562 trimer interface [polypeptide binding]; other site 273068004563 active site 273068004564 dimer interface [polypeptide binding]; other site 273068004565 Pfam match to entry DHquinase_II, Dehydroquinase class II, score 232.8, E-value 4.90E-66 273068004566 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 273068004567 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 273068004568 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 273068004569 active site 273068004570 Pfam match to entry Peptidase_M24, metallopeptidase family M24, score 270.3, E-value 2.50E-77 273068004571 elongation factor P; Validated; Region: PRK00529 273068004572 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 273068004573 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 273068004574 RNA binding site [nucleotide binding]; other site 273068004575 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 273068004576 RNA binding site [nucleotide binding]; other site 273068004577 Pfam match to entry EFP, Elongation factor P (EF-P), score 368.6, E-value 6.40E-107 273068004578 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 273068004579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004580 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 273068004581 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 273068004582 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 273068004583 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 273068004584 stage III sporulation protein AF; Region: spore_III_AF; TIGR02896 273068004585 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 273068004586 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 273068004587 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 273068004588 Protein of unknown function (DUF322); Region: DUF322; cl00574 273068004589 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 273068004590 putative RNA binding site [nucleotide binding]; other site 273068004591 Pfam match to entry NusB, NusB family, score 143, E-value 5.10E-39 273068004592 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 273068004593 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 273068004594 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 273068004595 homodimer interface [polypeptide binding]; other site 273068004596 NADP binding site [chemical binding]; other site 273068004597 substrate binding site [chemical binding]; other site 273068004598 Pfam match to entry THF_DHG_CYH, Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain, score 128.9, E-value 9.20E-35 273068004599 Pfam match to entry THF_DHG_CYH_C, Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain, score 295.8, E-value 5.50E-85 273068004600 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 273068004601 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 273068004602 generic binding surface II; other site 273068004603 generic binding surface I; other site 273068004604 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 273068004605 Pfam match to entry tRNA_anti, OB-fold nucleic acid binding domain, score 50.6, E-value 3.60E-11 273068004606 Pfam match to entry Exonuc_VII_L, Exonuclease VII, large subunit, score 177.9, E-value 1.60E-49 273068004607 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 273068004608 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 273068004609 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 273068004610 substrate binding pocket [chemical binding]; other site 273068004611 chain length determination region; other site 273068004612 substrate-Mg2+ binding site; other site 273068004613 catalytic residues [active] 273068004614 aspartate-rich region 1; other site 273068004615 active site lid residues [active] 273068004616 aspartate-rich region 2; other site 273068004617 Pfam match to entry polyprenyl_synt, Polyprenyl synthetase, score 329.1, E-value 5.00E-95 273068004618 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 273068004619 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 273068004620 TPP-binding site; other site 273068004621 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 273068004622 PYR/PP interface [polypeptide binding]; other site 273068004623 dimer interface [polypeptide binding]; other site 273068004624 TPP binding site [chemical binding]; other site 273068004625 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273068004626 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 273068004627 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273068004628 RNA binding surface [nucleotide binding]; other site 273068004629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 273068004630 Pfam match to entry S4, S4 domain, score 59, E-value 1.00E-13 273068004631 Pfam match to entry FtsJ, FtsJ-like methyltransferase, score 32.7, E-value 2.20E-08 273068004632 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 273068004633 Pfam match to entry DUF15, Domain of unknown function DUF15, score 305.9, E-value 4.80E-88 273068004634 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 273068004635 arginine repressor; Provisional; Region: argR; PRK00441 273068004636 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 273068004637 Pfam match to entry Arg_repressor, Arginine repressor, DNA binding domain, score 98.3, E-value 1.50E-25 273068004638 Pfam match to entry Arg_repressor_C, Arginine repressor, C-terminal domain, score 108.8, E-value 1.80E-29 273068004639 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 273068004640 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 273068004641 Walker A/P-loop; other site 273068004642 ATP binding site [chemical binding]; other site 273068004643 Q-loop/lid; other site 273068004644 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 273068004645 ABC transporter signature motif; other site 273068004646 Walker B; other site 273068004647 D-loop; other site 273068004648 H-loop/switch region; other site 273068004649 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 273068004650 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 273068004651 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 273068004652 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 273068004653 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068004654 active site 273068004655 phosphorylation site [posttranslational modification] 273068004656 intermolecular recognition site; other site 273068004657 dimerization interface [polypeptide binding]; other site 273068004658 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 273068004659 Pfam match to entry response_reg, Response regulator receiver domain, score 96, E-value 7.40E-25 273068004660 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 273068004661 Thiamine pyrophosphokinase; Region: TPK; cl08415 273068004662 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 273068004663 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 273068004664 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 273068004665 Ligand binding site; other site 273068004666 Putative Catalytic site; other site 273068004667 DXD motif; other site 273068004668 Pfam match to entry Glycos_transf_2, Glycosyl transferase, score 114.4, E-value 2.20E-30 273068004669 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 273068004670 Mg++ binding site [ion binding]; other site 273068004671 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 273068004672 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 273068004673 dimer interface [polypeptide binding]; other site 273068004674 ADP-ribose binding site [chemical binding]; other site 273068004675 active site 273068004676 nudix motif; other site 273068004677 metal binding site [ion binding]; metal-binding site 273068004678 Pfam match to entry mutT, MutT-like domain, score 97.9, E-value 2.00E-25 273068004679 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 273068004680 Integral membrane protein DUF95; Region: DUF95; cl00572 273068004681 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 273068004682 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 273068004683 active site 273068004684 Int/Topo IB signature motif; other site 273068004685 Pfam match to entry Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 66.9, E-value 4.20E-16 273068004686 Pfam match to entry Phage_integrase, Phage integrase family, score 99.4, E-value 7.00E-26 273068004687 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 273068004688 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 273068004689 Pfam match to entry Peptidase_S11, D-alanyl-D-alanine carboxypeptidase, score 368.7, E-value 5.90E-107 273068004690 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 273068004691 anti sigma factor interaction site; other site 273068004692 regulatory phosphorylation site [posttranslational modification]; other site 273068004693 Pfam match to entry STAS, STAS domain, score 99.1, E-value 8.50E-26 273068004694 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068004695 ATP binding site [chemical binding]; other site 273068004696 Mg2+ binding site [ion binding]; other site 273068004697 G-X-G motif; other site 273068004698 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 52.1, E-value 4.80E-13 273068004699 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 273068004700 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068004701 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273068004702 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068004703 DNA binding residues [nucleotide binding] 273068004704 Pfam match to entry sigma70, Sigma-70 factor, score 238.1, E-value 1.20E-67 273068004705 Dodecin; Region: Dodecin; cl01328 273068004706 SpoVA protein; Region: SpoVA; cl04298 273068004707 stage V sporulation protein AD; Validated; Region: PRK08304 273068004708 stage V sporulation protein AD; Provisional; Region: PRK12404 273068004709 SpoVA protein; Region: SpoVA; cl04298 273068004710 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 273068004711 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 273068004712 active site 273068004713 NTP binding site [chemical binding]; other site 273068004714 metal binding triad [ion binding]; metal-binding site 273068004715 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 273068004716 Pfam match to entry PolyA_pol, Poly A polymerase family, score 149.3, E-value 6.90E-41 273068004717 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 273068004718 active site 273068004719 putative substrate binding region [chemical binding]; other site 273068004720 ScpA/B protein; Region: ScpA_ScpB; cl00598 273068004721 Pfam match to entry DUF173, Uncharacterized ACR, COG1354, score 104.2, E-value 2.60E-27 273068004722 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 273068004723 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 273068004724 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 273068004725 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 273068004726 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068004727 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 273068004728 Pfam match to entry Peptidase_S11, D-alanyl-D-alanine carboxypeptidase, score 334.6, E-value 1.10E-96 273068004729 hypothetical protein; Provisional; Region: PRK05802 273068004730 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 273068004731 FAD binding pocket [chemical binding]; other site 273068004732 FAD binding motif [chemical binding]; other site 273068004733 phosphate binding motif [ion binding]; other site 273068004734 beta-alpha-beta structure motif; other site 273068004735 NAD binding pocket [chemical binding]; other site 273068004736 Iron coordination center [ion binding]; other site 273068004737 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 273068004738 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273068004739 RNA binding surface [nucleotide binding]; other site 273068004740 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 273068004741 active site 273068004742 Pfam match to entry S4, S4 domain, score 62.8, E-value 7.40E-15 273068004743 Pfam match to entry PseudoU_synth_2, RNA pseudouridylate synthase, score 94.3, E-value 2.50E-24 273068004744 spermidine synthase; Provisional; Region: PRK00811 273068004745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068004746 S-adenosylmethionine binding site [chemical binding]; other site 273068004747 Pfam match to entry Spermine_synth, Spermine/spermidine synthase, score 394.9, E-value 7.90E-115 273068004748 Arginase family; Region: Arginase; cl00306 273068004749 Pfam match to entry arginase, Arginase family, score 177, E-value 3.20E-49 273068004750 oxaloacetate decarboxylase; Provisional; Region: PRK12331 273068004751 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 273068004752 active site 273068004753 catalytic residues [active] 273068004754 metal binding site [ion binding]; metal-binding site 273068004755 homodimer binding site [polypeptide binding]; other site 273068004756 Pfam match to entry HMGL-like, HMGL-like, score 211.6, E-value 1.20E-59 273068004757 Pfam match to entry PYC_OADA, Conserved carboxylase domain, score 253.7, E-value 2.50E-72 273068004758 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068004759 putative peptidoglycan binding site; other site 273068004760 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068004761 putative peptidoglycan binding site; other site 273068004762 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068004763 putative peptidoglycan binding site; other site 273068004764 Pfam match to entry LysM, LysM domain, score 76.3, E-value 6.20E-19 273068004765 Pfam match to entry LysM, LysM domain, score 76.8, E-value 4.60E-19 273068004766 Pfam match to entry LysM, LysM domain, score 72.9, E-value 6.60E-18 273068004767 Survival protein SurE; Region: SurE; cl00448 273068004768 Pfam match to entry SurE, Survival protein SurE, score 284, E-value 1.90E-81 273068004769 Ferredoxin [Energy production and conversion]; Region: COG1146 273068004770 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 273068004771 Pfam match to entry fer4, 4Fe-4S binding domain, score 34.5, E-value 2.50E-06 273068004772 Pfam match to entry fer4, 4Fe-4S binding domain, score 33.4, E-value 5.30E-06 273068004773 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 273068004774 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273068004775 dimer interface [polypeptide binding]; other site 273068004776 PYR/PP interface [polypeptide binding]; other site 273068004777 TPP binding site [chemical binding]; other site 273068004778 substrate binding site [chemical binding]; other site 273068004779 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273068004780 Pfam match to entry POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 347.2, E-value 1.80E-100 273068004781 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778 273068004782 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 273068004783 TPP-binding site [chemical binding]; other site 273068004784 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 273068004785 Pfam match to entry POR, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 158.2, E-value 1.40E-43 273068004786 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273068004787 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273068004788 putative active site [active] 273068004789 Pfam match to entry HTH_6, Helix-turn-helix domain, rpiR family, score 48.4, E-value 1.50E-10 273068004790 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 273068004791 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 273068004792 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 273068004793 NAD(P) binding site [chemical binding]; other site 273068004794 Pfam match to entry GLFV_dehydrog_N, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, score 276.1, E-value 4.40E-79 273068004795 Pfam match to entry GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, score 356.5, E-value 2.90E-103 273068004796 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273068004797 catalytic core [active] 273068004798 Pfam match to entry PGAM, Phosphoglycerate mutase family, score 193.8, E-value 2.80E-54 273068004799 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068004800 flavoprotein, HI0933 family; Region: TIGR00275 273068004801 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 273068004802 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 273068004803 homotrimer interaction site [polypeptide binding]; other site 273068004804 active site 273068004805 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 273068004806 cytidylate kinase; Provisional; Region: cmk; PRK00023 273068004807 CMP-binding site; other site 273068004808 The sites determining sugar specificity; other site 273068004809 Pfam match to entry Cytidylate_kin, Cytidylate kinase, score 263.9, E-value 2.10E-75 273068004810 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 273068004811 putative acyl-acceptor binding pocket; other site 273068004812 Pfam match to entry Acyltransferase, Acyltransferase, score 139.1, E-value 8.10E-38 273068004813 LytB protein; Region: LYTB; cl00507 273068004814 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 273068004815 Pfam match to entry LYTB, LytB protein, score 427.4, E-value 1.30E-124 273068004816 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 273068004817 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 273068004818 RNA binding site [nucleotide binding]; other site 273068004819 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 273068004820 RNA binding site [nucleotide binding]; other site 273068004821 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273068004822 RNA binding site [nucleotide binding]; other site 273068004823 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273068004824 RNA binding site [nucleotide binding]; other site 273068004825 Pfam match to entry S1, S1 RNA binding domain, score 41.5, E-value 7.20E-10 273068004826 Pfam match to entry S1, S1 RNA binding domain, score 34.5, E-value 6.30E-08 273068004827 Pfam match to entry S1, S1 RNA binding domain, score 94.2, E-value 2.00E-24 273068004828 Pfam match to entry S1, S1 RNA binding domain, score 47.7, E-value 1.40E-11 273068004829 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 273068004830 Pfam match to entry DUF206, S-adenosylmethionine decarboxylase, score 207.3, E-value 2.30E-58 273068004831 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 273068004832 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 273068004833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068004834 Pfam match to entry CheR, CheR methyltransferase, score 301.9, E-value 7.50E-87 273068004835 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 273068004836 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 273068004837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004838 FeS/SAM binding site; other site 273068004839 TRAM domain; Region: TRAM; cl01282 273068004840 Pfam match to entry UPF0004, Uncharacterized protein family UPF0004, score 150.6, E-value 2.80E-41 273068004841 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 273068004842 MutS domain I; Region: MutS_I; pfam01624 273068004843 MutS domain II; Region: MutS_II; pfam05188 273068004844 MutS family domain IV; Region: MutS_IV; pfam05190 273068004845 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 273068004846 Walker A/P-loop; other site 273068004847 ATP binding site [chemical binding]; other site 273068004848 Q-loop/lid; other site 273068004849 ABC transporter signature motif; other site 273068004850 Walker B; other site 273068004851 D-loop; other site 273068004852 H-loop/switch region; other site 273068004853 Pfam match to entry MutS_N, MutS family, N-terminal putative DNA binding domain, score 623.8, E-value 9.60E-184 273068004854 Pfam match to entry MutS_C, DNA mismatch repair proteins, mutS family, score 506.4, E-value 2.10E-148 273068004855 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 273068004856 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068004857 ATP binding site [chemical binding]; other site 273068004858 Mg2+ binding site [ion binding]; other site 273068004859 G-X-G motif; other site 273068004860 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 273068004861 ATP binding site [chemical binding]; other site 273068004862 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 273068004863 Pfam match to entry DNA_mis_repair, DNA mismatch repair protein, score 186.9, E-value 3.30E-52 273068004864 IPP transferase; Region: IPPT; cl00403 273068004865 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 273068004866 Pfam match to entry IPPT, IPP transferase, score 389.5, E-value 3.30E-113 273068004867 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 273068004868 Sm1 motif; other site 273068004869 intra - hexamer interaction site; other site 273068004870 inter - hexamer interaction site [polypeptide binding]; other site 273068004871 nucleotide binding pocket [chemical binding]; other site 273068004872 Sm2 motif; other site 273068004873 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068004874 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 273068004875 Pfam match to entry P5CR, Delta 1-pyrroline-5-carboxylate reductase, score 368, E-value 9.70E-107 273068004876 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 273068004877 RNA/DNA hybrid binding site [nucleotide binding]; other site 273068004878 active site 273068004879 Pfam match to entry rnaseH, RNase H, score 190.4, E-value 2.90E-53 273068004880 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 273068004881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 273068004882 DNA binding site [nucleotide binding] 273068004883 Int/Topo IB signature motif; other site 273068004884 active site 273068004885 Pfam match to entry Phage_integr_N, Phage integrase, N-terminal SAM-like domain, score 47.8, E-value 2.30E-10 273068004886 Pfam match to entry Phage_integrase, Phage integrase family, score 163.9, E-value 2.70E-45 273068004887 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 273068004888 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273068004889 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273068004890 catalytic residue [active] 273068004891 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 273068004892 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292 273068004893 active site 273068004894 stage V sporulation protein K; Region: spore_V_K; TIGR02881 273068004895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068004896 Walker A motif; other site 273068004897 ATP binding site [chemical binding]; other site 273068004898 Walker B motif; other site 273068004899 arginine finger; other site 273068004900 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 106.9, E-value 3.80E-28 273068004901 adenylosuccinate lyase; Region: purB; TIGR00928 273068004902 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 273068004903 tetramer interface [polypeptide binding]; other site 273068004904 active site 273068004905 Pfam match to entry lyase_1, Lyase, score 227.8, E-value 1.50E-64 273068004906 aspartate aminotransferase; Provisional; Region: PRK05764 273068004907 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273068004908 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068004909 homodimer interface [polypeptide binding]; other site 273068004910 catalytic residue [active] 273068004911 Pfam match to entry aminotran_1, Aminotransferase class-I, score 359.7, E-value 3.10E-104 273068004912 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 273068004913 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 273068004914 Pfam match to entry PHP_N, PHP domain N-terminal region, score 93.6, E-value 3.90E-24 273068004915 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 273068004916 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 273068004917 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 273068004918 putative active site [active] 273068004919 metal binding site [ion binding]; metal-binding site 273068004920 homodimer binding site [polypeptide binding]; other site 273068004921 Pfam match to entry DUF189, Uncharacterized BCR, YmdB family COG1692, score 472.3, E-value 4.00E-138 273068004922 phosphodiesterase; Provisional; Region: PRK12704 273068004923 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 273068004924 Pfam match to entry HD, HD domain, score 84.6, E-value 2.10E-21 273068004925 RecX family; Region: RecX; cl00936 273068004926 Pfam match to entry RecX, RecX family, score 29.1, E-value 3.60E-06 273068004927 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 273068004928 protein RecA; Region: tigrfam_recA; TIGR02012 273068004929 hexamer interface [polypeptide binding]; other site 273068004930 Walker A motif; other site 273068004931 ATP binding site [chemical binding]; other site 273068004932 Walker B motif; other site 273068004933 Pfam match to entry recA, recA bacterial DNA recombination protein, score 738.1, E-value 3.80E-218 273068004934 competence damage-inducible protein A; Provisional; Region: PRK00549 273068004935 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 273068004936 putative MPT binding site; other site 273068004937 Competence-damaged protein; Region: CinA; cl00666 273068004938 Pfam match to entry CinA, Competence-damaged protein, score 278.3, E-value 9.60E-80 273068004939 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 273068004940 Pfam match to entry CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase, score 150.9, E-value 2.30E-41 273068004941 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 273068004942 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 273068004943 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068004944 FeS/SAM binding site; other site 273068004945 Pfam match to entry UPF0004, Uncharacterized protein family UPF0004, score 143.6, E-value 3.50E-39 273068004946 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068004947 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 273068004948 Pfam match to entry FtsK_SpoIIIE, FtsK/SpoIIIE family, score 300.6, E-value 1.90E-86 273068004949 Transposase domain (DUF772); Region: DUF772; cl12084 273068004950 YlzJ-like protein; Region: YlzJ; pfam14035 273068004951 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 273068004952 active site 273068004953 aspartate kinase I; Reviewed; Region: PRK08210 273068004954 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 273068004955 nucleotide binding site [chemical binding]; other site 273068004956 substrate binding site [chemical binding]; other site 273068004957 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 273068004958 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 273068004959 Pfam match to entry aakinase, Amino acid kinase family, score 240.8, E-value 1.90E-68 273068004960 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 273068004961 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 273068004962 trimer interface [polypeptide binding]; other site 273068004963 active site 273068004964 Pfam match to entry dUTPase, dUTPase, score 130.7, E-value 2.60E-35 273068004965 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 273068004966 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 273068004967 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273068004968 Pfam match to entry Peptidase_M16, Insulinase (Peptidase family M16), score 170.9, E-value 2.20E-47 273068004969 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 273068004970 NodB motif; other site 273068004971 Pfam match to entry Polysac_deacet, Polysaccharide deacetylase, score 165.2, E-value 1.10E-45 273068004972 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 273068004973 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 273068004974 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 273068004975 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 273068004976 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 273068004977 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 273068004978 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 273068004979 putative nucleic acid binding region [nucleotide binding]; other site 273068004980 G-X-X-G motif; other site 273068004981 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 273068004982 RNA binding site [nucleotide binding]; other site 273068004983 domain interface; other site 273068004984 Pfam match to entry S1, S1 RNA binding domain, score 74.3, E-value 6.20E-19 273068004985 Pfam match to entry KH-domain, KH domain, score 40.3, E-value 4.40E-08 273068004986 Pfam match to entry RNase_PH, 3' exoribonuclease family, score 290.9, E-value 1.50E-83 273068004987 Pfam match to entry RNase_PH, 3' exoribonuclease family, score 190.3, E-value 3.00E-53 273068004988 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 273068004989 16S/18S rRNA binding site [nucleotide binding]; other site 273068004990 S13e-L30e interaction site [polypeptide binding]; other site 273068004991 25S rRNA binding site [nucleotide binding]; other site 273068004992 Pfam match to entry Ribosomal_S15, Ribosomal protein S15, score 148.2, E-value 1.40E-40 273068004993 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 273068004994 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 273068004995 active site 273068004996 Riboflavin kinase; Region: Flavokinase; cl03312 273068004997 Pfam match to entry FAD_Synth, Riboflavin kinase / FAD synthetase, score 162.9, E-value 5.60E-45 273068004998 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 273068004999 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 273068005000 RNA binding site [nucleotide binding]; other site 273068005001 active site 273068005002 Pfam match to entry TruB_N, TruB family pseudouridylate synthase (N terminal domain), score 243, E-value 4.10E-69 273068005003 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 273068005004 DHH family; Region: DHH; pfam01368 273068005005 Pfam match to entry DHHA1, DHHA1 domain, score 37.3, E-value 3.60E-07 273068005006 Pfam match to entry DHH, DHH family, score 89.3, E-value 7.70E-23 273068005007 Ribosome-binding factor A; Region: RBFA; cl00542 273068005008 Pfam match to entry RBFA, Ribosome-binding factor A, score 170.8, E-value 2.30E-47 273068005009 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 273068005010 translation initiation factor IF-2; Region: IF-2; TIGR00487 273068005011 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 273068005012 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 273068005013 G1 box; other site 273068005014 putative GEF interaction site [polypeptide binding]; other site 273068005015 GTP/Mg2+ binding site [chemical binding]; other site 273068005016 Switch I region; other site 273068005017 G2 box; other site 273068005018 G3 box; other site 273068005019 Switch II region; other site 273068005020 G4 box; other site 273068005021 G5 box; other site 273068005022 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 273068005023 Translation-initiation factor 2; Region: IF-2; pfam11987 273068005024 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 273068005025 Pfam match to entry IF2, Initiation factor 2, score 266.5, E-value 3.60E-76 273068005026 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 283.2, E-value 3.30E-81 273068005027 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 273068005028 Pfam match to entry Ribosomal_L7Ae, Ribosomal protein L7Ae/L30e/S12e/Gadd45 family, score 68.6, E-value 1.30E-16 273068005029 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 273068005030 putative RNA binding cleft [nucleotide binding]; other site 273068005031 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 273068005032 NusA N-terminal domain; Region: NusA_N; pfam08529 273068005033 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 273068005034 RNA binding site [nucleotide binding]; other site 273068005035 homodimer interface [polypeptide binding]; other site 273068005036 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 273068005037 G-X-X-G motif; other site 273068005038 Pfam match to entry S1, S1 RNA binding domain, score 40.4, E-value 1.40E-09 273068005039 ribosome maturation protein RimP; Reviewed; Region: PRK00092 273068005040 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 273068005041 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 273068005042 Sm1 motif; other site 273068005043 predicted subunit interaction site [polypeptide binding]; other site 273068005044 RNA binding pocket [nucleotide binding]; other site 273068005045 Sm2 motif; other site 273068005046 Pfam match to entry DUF150, Uncharacterized BCR, YhbC family COG0779, score 171.8, E-value 1.10E-47 273068005047 DNA polymerase III PolC; Validated; Region: polC; PRK00448 273068005048 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 273068005049 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 273068005050 generic binding surface II; other site 273068005051 generic binding surface I; other site 273068005052 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 273068005053 active site 273068005054 substrate binding site [chemical binding]; other site 273068005055 catalytic site [active] 273068005056 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 273068005057 Pfam match to entry PHP_C, PHP domain C-terminal region, score 93.1, E-value 5.70E-24 273068005058 Pfam match to entry Exonuclease, Exonuclease, score 191.9, E-value 1.00E-53 273068005059 Pfam match to entry PHP_N, PHP domain N-terminal region, score 97.4, E-value 2.90E-25 273068005060 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 273068005061 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 273068005062 Ligand binding site; other site 273068005063 DXD motif; other site 273068005064 Putative Catalytic site; other site 273068005065 Pfam match to entry Glycos_transf_2, Glycosyl transferase, score 114.8, E-value 1.70E-30 273068005066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 273068005067 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 273068005068 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 273068005069 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 273068005070 active site 273068005071 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 273068005072 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 273068005073 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 273068005074 putative substrate binding region [chemical binding]; other site 273068005075 putative substrate binding region [chemical binding]; other site 273068005076 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 273068005077 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 273068005078 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 273068005079 Pfam match to entry DXP_reductoisom, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, score 699.5, E-value 1.60E-206 273068005080 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 273068005081 Pfam match to entry Cytidylyltrans, Phosphatidate cytidylyltransferase, score 93.3, E-value 4.70E-24 273068005082 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 273068005083 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 273068005084 catalytic residue [active] 273068005085 putative FPP diphosphate binding site; other site 273068005086 putative FPP binding hydrophobic cleft; other site 273068005087 dimer interface [polypeptide binding]; other site 273068005088 putative IPP diphosphate binding site; other site 273068005089 Pfam match to entry UPP_synthetase, Putative undecaprenyl diphosphate synthase, score 429.4, E-value 3.20E-125 273068005090 ribosome recycling factor; Reviewed; Region: frr; PRK00083 273068005091 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 273068005092 hinge region; other site 273068005093 Pfam match to entry RRF, Ribosome recycling factor, score 328.6, E-value 7.20E-95 273068005094 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 273068005095 putative nucleotide binding site [chemical binding]; other site 273068005096 uridine monophosphate binding site [chemical binding]; other site 273068005097 homohexameric interface [polypeptide binding]; other site 273068005098 Pfam match to entry aakinase, Amino acid kinase family, score 236.6, E-value 3.50E-67 273068005099 elongation factor Ts; Reviewed; Region: tsf; PRK12332 273068005100 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 273068005101 Elongation factor TS; Region: EF_TS; pfam00889 273068005102 Pfam match to entry EF_TS, Elongation factor TS, score 242.1, E-value 2.90E-69 273068005103 Pfam match to entry TS-N, TS-N domain, score 80.5, E-value 3.30E-20 273068005104 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 273068005105 rRNA interaction site [nucleotide binding]; other site 273068005106 S8 interaction site; other site 273068005107 putative laminin-1 binding site; other site 273068005108 Pfam match to entry Ribosomal_S2, Ribosomal protein S2, score 386.5, E-value 2.70E-112 273068005109 Protein of unknown function (DUF342); Region: DUF342; pfam03961 273068005110 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 273068005111 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068005112 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273068005113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068005114 DNA binding residues [nucleotide binding] 273068005115 Pfam match to entry sigma70, Sigma-70 factor, score 258.9, E-value 6.60E-74 273068005116 CheD chemotactic sensory transduction; Region: CheD; cl00810 273068005117 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 273068005118 Chemotaxis phosphatase CheX; Region: CheX; cl15816 273068005119 Chemotaxis phosphatase CheX; Region: CheX; cl15816 273068005120 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 273068005121 putative CheA interaction surface; other site 273068005122 Pfam match to entry CheW, CheW-like domain, score 137.9, E-value 1.90E-37 273068005123 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 273068005124 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 273068005125 putative binding surface; other site 273068005126 active site 273068005127 P2 response regulator binding domain; Region: P2; pfam07194 273068005128 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 273068005129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068005130 ATP binding site [chemical binding]; other site 273068005131 Mg2+ binding site [ion binding]; other site 273068005132 G-X-G motif; other site 273068005133 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 273068005134 Pfam match to entry CheW, CheW-like domain, score 75, E-value 1.60E-18 273068005135 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 119.8, E-value 5.00E-32 273068005136 Pfam match to entry H-kinase_dim, Signal transducing histidine kinase, homodimeric domain, score 74.5, E-value 2.20E-18 273068005137 Pfam match to entry Hpt, Hpt domain, score 170.6, E-value 2.50E-47 273068005138 CheB methylesterase; Region: CheB_methylest; pfam01339 273068005139 Pfam match to entry CheB_methylest, CheB methylesterase, score 202.2, E-value 7.80E-57 273068005140 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 273068005141 Flagellar protein YcgR; Region: YcgR_2; pfam12945 273068005142 PilZ domain; Region: PilZ; cl01260 273068005143 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 273068005144 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068005145 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 273068005146 Pfam match to entry ParA, ParA family ATPase, score 28.6, E-value 4.50E-06 273068005147 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 273068005148 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068005149 GTP/Mg2+ binding site [chemical binding]; other site 273068005150 G4 box; other site 273068005151 G5 box; other site 273068005152 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 273068005153 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068005154 G1 box; other site 273068005155 Pfam match to entry SRP54, SRP54-type protein, GTPase domain, score 152.9, E-value 1.30E-43 273068005156 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 273068005157 FHIPEP family; Region: FHIPEP; pfam00771 273068005158 Pfam match to entry FHIPEP, FHIPEP family, score 1118.8, E-value 0 273068005159 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 273068005160 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 273068005161 Pfam match to entry Bac_export_2, FlhB HrpN YscU SpaS Family, score 448.9, E-value 4.50E-131 273068005162 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 273068005163 Pfam match to entry Bac_export_1, Bacterial export proteins, family 1, score 157, E-value 3.30E-43 273068005164 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 273068005165 Pfam match to entry Bac_export_3, Bacterial export proteins, family 3, score 132.8, E-value 6.20E-36 273068005166 FliP family; Region: FliP; cl00593 273068005167 Pfam match to entry FliP, FliP family, score 407.7, E-value 1.10E-118 273068005168 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 273068005169 Response regulator receiver domain; Region: Response_reg; pfam00072 273068005170 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068005171 active site 273068005172 phosphorylation site [posttranslational modification] 273068005173 intermolecular recognition site; other site 273068005174 dimerization interface [polypeptide binding]; other site 273068005175 Pfam match to entry response_reg, Response regulator receiver domain, score 138.6, E-value 1.10E-37 273068005176 flagellar motor switch protein; Validated; Region: PRK08119 273068005177 Chemotaxis phosphatase CheX; Region: CheX; cl15816 273068005178 Chemotaxis phosphatase CheX; Region: CheX; cl15816 273068005179 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 273068005180 Pfam match to entry SpoA, Surface presentation of antigens (SPOA) protein, score 120.4, E-value 3.40E-32 273068005181 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 273068005182 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 273068005183 Pfam match to entry SpoA, Surface presentation of antigens (SPOA) protein, score 37.8, E-value 2.40E-07 273068005184 Pfam match to entry FliM, Flagellar motor switch protein FliM, score 263.7, E-value 2.40E-75 273068005185 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 273068005186 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 273068005187 Flagellar protein (FlbD); Region: FlbD; cl00683 273068005188 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 273068005189 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 273068005190 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 273068005191 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 273068005192 Pfam match to entry flg_bb_rod, Flagella basal body rod protein, score 58.3, E-value 1.30E-13 273068005193 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 273068005194 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 273068005195 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 273068005196 MgtE intracellular N domain; Region: MgtE_N; cl15244 273068005197 Flagellar FliJ protein; Region: FliJ; cl09161 273068005198 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 273068005199 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 273068005200 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 273068005201 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 273068005202 Walker A motif/ATP binding site; other site 273068005203 Walker B motif; other site 273068005204 Pfam match to entry ATP-synt_ab, ATP synthase alpha/beta family, nucleotide-binding domain, score 532.9, E-value 2.30E-156 273068005205 Pfam match to entry ATP-synt_ab_N, ATP synthase alpha/beta family, beta-barrel domain, score 50.5, E-value 3.70E-11 273068005206 Flagellar assembly protein FliH; Region: FliH; pfam02108 273068005207 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 273068005208 FliG C-terminal domain; Region: FliG_C; pfam01706 273068005209 Pfam match to entry FliG-C, FliG C-terminal domain, score 207, E-value 2.90E-58 273068005210 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 273068005211 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 273068005212 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 273068005213 Pfam match to entry YscJ_FliF, Secretory protein of YscJ/FliF family, score 132.7, E-value 6.50E-36 273068005214 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 273068005215 Pfam match to entry FliE, Flagellar hook-basal body complex protein FliE, score 82.9, E-value 6.40E-21 273068005216 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 273068005217 Flagella basal body rod protein; Region: Flg_bb_rod; cl15793 273068005218 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 273068005219 Pfam match to entry flg_bb_rod, Flagella basal body rod protein, score 33, E-value 7.40E-07 273068005220 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 273068005221 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 273068005222 Pfam match to entry flg_bb_rod, Flagella basal body rod protein, score 34.7, E-value 2.60E-07 273068005223 transcriptional repressor CodY; Validated; Region: PRK04158 273068005224 CodY GAF-like domain; Region: CodY; pfam06018 273068005225 Helix-turn-helix domains; Region: HTH; cl00088 273068005226 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 273068005227 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068005228 Walker A motif; other site 273068005229 ATP binding site [chemical binding]; other site 273068005230 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068005231 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 273068005232 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 273068005233 active site 273068005234 HslU subunit interaction site [polypeptide binding]; other site 273068005235 DNA topoisomerase I; Validated; Region: PRK05582 273068005236 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 273068005237 active site 273068005238 interdomain interaction site; other site 273068005239 putative metal-binding site [ion binding]; other site 273068005240 nucleotide binding site [chemical binding]; other site 273068005241 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 273068005242 domain I; other site 273068005243 DNA binding groove [nucleotide binding] 273068005244 phosphate binding site [ion binding]; other site 273068005245 domain II; other site 273068005246 domain III; other site 273068005247 nucleotide binding site [chemical binding]; other site 273068005248 catalytic site [active] 273068005249 domain IV; other site 273068005250 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273068005251 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273068005252 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 273068005253 Pfam match to entry zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 58.4, E-value 1.60E-13 273068005254 Pfam match to entry zf-C4_Topoisom, Topoisomerase DNA binding C4 zinc finger, score 69, E-value 9.90E-17 273068005255 Pfam match to entry Topoisom_bac, DNA topoisomerase, score 592.9, E-value 1.90E-174 273068005256 Pfam match to entry Toprim, Toprim domain, score 138.7, E-value 1.00E-37 273068005257 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 273068005258 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 273068005259 Helix-turn-helix domains; Region: HTH; cl00088 273068005260 Pfam match to entry SMF, SMF family, score 349.4, E-value 3.80E-101 273068005261 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 273068005262 RNA/DNA hybrid binding site [nucleotide binding]; other site 273068005263 active site 273068005264 Pfam match to entry RNase_HII, Ribonuclease HII, score 241.4, E-value 1.30E-68 273068005265 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 273068005266 Pfam match to entry UPF0102, Uncharacterised protein family UPF0102, score 110.9, E-value 2.50E-29 273068005267 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 273068005268 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 273068005269 active site 273068005270 HIGH motif; other site 273068005271 dimer interface [polypeptide binding]; other site 273068005272 KMSKS motif; other site 273068005273 Pfam match to entry tRNA-synt_1b, tRNA synthetases class I (W and Y), score 379.7, E-value 2.90E-110 273068005274 Uncharacterized conserved protein [Function unknown]; Region: COG1284 273068005275 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 273068005276 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 273068005277 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 273068005278 Pfam match to entry DUF161, Uncharacterized BCR, YitT family COG1284, score 173.2, E-value 4.30E-48 273068005279 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 273068005280 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068005281 Walker A motif; other site 273068005282 ATP binding site [chemical binding]; other site 273068005283 Walker B motif; other site 273068005284 arginine finger; other site 273068005285 Pfam match to entry Mg_chelatase, Magnesium chelatase, subunit ChlI, score 246.6, E-value 3.40E-70 273068005286 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 273068005287 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 273068005288 GTP/Mg2+ binding site [chemical binding]; other site 273068005289 G4 box; other site 273068005290 G5 box; other site 273068005291 G1 box; other site 273068005292 Switch I region; other site 273068005293 G2 box; other site 273068005294 G3 box; other site 273068005295 Switch II region; other site 273068005296 Pfam match to entry MMR_HSR1, GTPase of unknown function, score 212, E-value 9.10E-60 273068005297 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 273068005298 Pfam match to entry Ribosomal_L19, Ribosomal protein L19, score 225.6, E-value 7.30E-64 273068005299 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 273068005300 Pfam match to entry tRNA_m1G_MT, tRNA (Guanine-1)-methyltransferase, score 435.8, E-value 3.80E-127 273068005301 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 273068005302 RimM N-terminal domain; Region: RimM; pfam01782 273068005303 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 273068005304 Pfam match to entry RimM, RimM, score 150.3, E-value 3.40E-41 273068005305 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 273068005306 hypothetical protein; Provisional; Region: PRK00468; cl00794 273068005307 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 273068005308 Pfam match to entry Ribosomal_S16, Ribosomal protein S16, score 136, E-value 6.80E-37 273068005309 signal recognition particle protein; Provisional; Region: PRK10867 273068005310 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 273068005311 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 273068005312 P loop; other site 273068005313 GTP binding site [chemical binding]; other site 273068005314 Signal peptide binding domain; Region: SRP_SPB; pfam02978 273068005315 Pfam match to entry SRP54, SRP54-type protein, GTPase domain, score 424.9, E-value 7.30E-124 273068005316 Pfam match to entry SRP54_N, SRP54-type protein, helical bundle domain, score 121.1, E-value 2.10E-32 273068005317 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068005318 DNA binding residues [nucleotide binding] 273068005319 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 273068005320 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 273068005321 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 273068005322 P loop; other site 273068005323 GTP binding site [chemical binding]; other site 273068005324 Pfam match to entry SRP54, SRP54-type protein, GTPase domain, score 422.5, E-value 3.90E-123 273068005325 Pfam match to entry SRP54_N, SRP54-type protein, helical bundle domain, score 47.5, E-value 3.00E-10 273068005326 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 273068005327 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 273068005328 Walker A/P-loop; other site 273068005329 ATP binding site [chemical binding]; other site 273068005330 Q-loop/lid; other site 273068005331 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 273068005332 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 273068005333 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 273068005334 ABC transporter signature motif; other site 273068005335 Walker B; other site 273068005336 D-loop; other site 273068005337 H-loop/switch region; other site 273068005338 Pfam match to entry SMC_C, SMC family, C-terminal domain, score 361.2, E-value 1.10E-104 273068005339 Pfam match to entry SMC_N, SMC domain N terminal domain, score 293.4, E-value 2.70E-84 273068005340 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 273068005341 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 273068005342 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 273068005343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068005344 FeS/SAM binding site; other site 273068005345 ribonuclease III; Reviewed; Region: rnc; PRK00102 273068005346 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 273068005347 dimerization interface [polypeptide binding]; other site 273068005348 active site 273068005349 metal binding site [ion binding]; metal-binding site 273068005350 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 273068005351 dsRNA binding site [nucleotide binding]; other site 273068005352 Pfam match to entry dsrm, Double-stranded RNA binding motif, score 85.2, E-value 1.30E-21 273068005353 Pfam match to entry Ribonuclease_3, RNase3 domain., score 139, E-value 8.40E-38 273068005354 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 273068005355 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 273068005356 dimer interface [polypeptide binding]; other site 273068005357 active site 273068005358 Pfam match to entry ketoacyl-synt_C, Beta-ketoacyl synthase, C-terminal domain, score 238.8, E-value 7.70E-68 273068005359 Pfam match to entry ketoacyl-synt, Beta-ketoacyl synthase, N-terminal domain, score 295.3, E-value 7.70E-85 273068005360 Phosphopantetheine attachment site; Region: PP-binding; cl09936 273068005361 Pfam match to entry pp-binding, Phosphopantetheine attachment site, score 95.2, E-value 9.80E-25 273068005362 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 273068005363 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 273068005364 NAD(P) binding site [chemical binding]; other site 273068005365 homotetramer interface [polypeptide binding]; other site 273068005366 homodimer interface [polypeptide binding]; other site 273068005367 active site 273068005368 Pfam match to entry adh_short_C2, Short chain dehydrogenase/reductase C-terminus, score 59.2, E-value 3.40E-15 273068005369 Pfam match to entry adh_short, short chain dehydrogenase, score 283.1, E-value 3.60E-81 273068005370 Acyl transferase domain; Region: Acyl_transf_1; cl08282 273068005371 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 273068005372 Pfam match to entry Acyl_transf, Acyl transferase domain, score 257, E-value 2.50E-73 273068005373 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 273068005374 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 273068005375 FMN binding site [chemical binding]; other site 273068005376 substrate binding site [chemical binding]; other site 273068005377 putative catalytic residue [active] 273068005378 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 273068005379 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 273068005380 dimer interface [polypeptide binding]; other site 273068005381 active site 273068005382 CoA binding pocket [chemical binding]; other site 273068005383 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 273068005384 Pfam match to entry FA_synthesis, Fatty acid synthesis protein, score 536.9, E-value 1.40E-157 273068005385 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 273068005386 Acetokinase family; Region: Acetate_kinase; cl01029 273068005387 Pfam match to entry Acetate_kinase, Acetokinase family, score 854.8, E-value 2.70E-253 273068005388 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 273068005389 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 273068005390 Pfam match to entry PTA_PTB, Phosphate acetyl/butaryl transferase, score 680.5, E-value 8.30E-201 273068005391 hypothetical protein; Provisional; Region: PRK13670 273068005392 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 273068005393 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 273068005394 Nucleoside recognition; Region: Gate; cl00486 273068005395 Nucleoside recognition; Region: Gate; cl00486 273068005396 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 273068005397 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 273068005398 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 273068005399 active site 273068005400 (T/H)XGH motif; other site 273068005401 Pfam match to entry Cytidylyltransf, Cytidylyltransferase, score 160.8, E-value 2.40E-44 273068005402 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068005403 S-adenosylmethionine binding site [chemical binding]; other site 273068005404 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 273068005405 Pfam match to entry SASP, Small, acid-soluble spore proteins, alpha/beta type, score 77.1, E-value 4.50E-20 273068005406 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 273068005407 Pfam match to entry SASP, Small, acid-soluble spore proteins, alpha/beta type, score 81.1, E-value 3.40E-21 273068005408 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 273068005409 Pfam match to entry DUF194, Uncharacterized protein, DegV family COG1307, score 183.9, E-value 2.50E-51 273068005410 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 273068005411 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 273068005412 generic binding surface II; other site 273068005413 ssDNA binding site; other site 273068005414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273068005415 ATP binding site [chemical binding]; other site 273068005416 putative Mg++ binding site [ion binding]; other site 273068005417 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273068005418 nucleotide binding region [chemical binding]; other site 273068005419 ATP-binding site [chemical binding]; other site 273068005420 Pfam match to entry helicase_C, Helicase conserved C-terminal domain, score 82.5, E-value 8.50E-21 273068005421 Pfam match to entry DEAD, DEAD/DEAH box helicase, score 80.9, E-value 1.10E-24 273068005422 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 273068005423 DAK2 domain; Region: Dak2; cl03685 273068005424 Pfam match to entry Dak2, Dak2 domain, score 152, E-value 1.00E-41 273068005425 Protein of unknown function (DUF322); Region: DUF322; cl00574 273068005426 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 273068005427 Pfam match to entry Ribosomal_L28, Ribosomal L28 family, score 66.5, E-value 5.50E-16 273068005428 Thiamine pyrophosphokinase; Region: TPK; cd07995 273068005429 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 273068005430 active site 273068005431 dimerization interface [polypeptide binding]; other site 273068005432 thiamine binding site [chemical binding]; other site 273068005433 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 273068005434 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 273068005435 substrate binding site [chemical binding]; other site 273068005436 hexamer interface [polypeptide binding]; other site 273068005437 metal binding site [ion binding]; metal-binding site 273068005438 Pfam match to entry Ribul_P_3_epim, Ribulose-phosphate 3 epimerase family, score 419.2, E-value 3.80E-122 273068005439 GTPase RsgA; Reviewed; Region: PRK00098 273068005440 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 273068005441 GTPase/OB domain interface [polypeptide binding]; other site 273068005442 GTPase/Zn-binding domain interface [polypeptide binding]; other site 273068005443 GTP/Mg2+ binding site [chemical binding]; other site 273068005444 G4 box; other site 273068005445 G5 box; other site 273068005446 G1 box; other site 273068005447 Switch I region; other site 273068005448 G2 box; other site 273068005449 G3 box; other site 273068005450 Switch II region; other site 273068005451 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 273068005452 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 273068005453 active site 273068005454 ATP binding site [chemical binding]; other site 273068005455 substrate binding site [chemical binding]; other site 273068005456 activation loop (A-loop); other site 273068005457 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 273068005458 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 273068005459 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 273068005460 Pfam match to entry pkinase, Protein kinase domain, score 256.5, E-value 3.70E-73 273068005461 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 273068005462 Protein phosphatase 2C; Region: PP2C; pfam00481 273068005463 active site 273068005464 Pfam match to entry PP2C, Protein phosphatase 2C, score 46.8, E-value 2.60E-12 273068005465 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 273068005466 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068005467 FeS/SAM binding site; other site 273068005468 16S rRNA methyltransferase B; Provisional; Region: PRK14902 273068005469 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 273068005470 putative RNA binding site [nucleotide binding]; other site 273068005471 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068005472 S-adenosylmethionine binding site [chemical binding]; other site 273068005473 Pfam match to entry Nol1_Nop2_Sun, NOL1/NOP2/sun family, score 202.1, E-value 8.20E-58 273068005474 Pfam match to entry NusB, NusB family, score 130.7, E-value 2.70E-35 273068005475 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 273068005476 Protein of unknown function DUF116; Region: DUF116; cl00800 273068005477 Pfam match to entry DUF116, Protein of unknown function DUF116, score 69.7, E-value 6.30E-17 273068005478 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 273068005479 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 273068005480 putative active site [active] 273068005481 substrate binding site [chemical binding]; other site 273068005482 putative cosubstrate binding site; other site 273068005483 catalytic site [active] 273068005484 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 273068005485 substrate binding site [chemical binding]; other site 273068005486 Pfam match to entry formyl_trans_C, Formyl transferase, C-terminal domain, score 118.4, E-value 1.40E-31 273068005487 Pfam match to entry formyl_transf, Formyl transferase, score 199, E-value 3.30E-56 273068005488 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 273068005489 active site 273068005490 catalytic residues [active] 273068005491 metal binding site [ion binding]; metal-binding site 273068005492 Pfam match to entry Pep_deformylase, Polypeptide deformylase, score 247.4, E-value 2.00E-70 273068005493 primosome assembly protein PriA; Validated; Region: PRK05580 273068005494 Helix-turn-helix domains; Region: HTH; cl00088 273068005495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273068005496 ATP binding site [chemical binding]; other site 273068005497 putative Mg++ binding site [ion binding]; other site 273068005498 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273068005499 ATP-binding site [chemical binding]; other site 273068005500 Pfam match to entry helicase_C, Helicase conserved C-terminal domain, score 34.3, E-value 2.80E-06 273068005501 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 273068005502 Flavoprotein; Region: Flavoprotein; cl08021 273068005503 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 273068005504 Pfam match to entry Flavoprotein, Flavoprotein, score 164.8, E-value 1.40E-45 273068005505 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 273068005506 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 273068005507 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 273068005508 catalytic site [active] 273068005509 G-X2-G-X-G-K; other site 273068005510 Pfam match to entry Guanylate_kin, Guanylate kinase, score 155.6, E-value 8.80E-43 273068005511 hypothetical protein; Provisional; Region: PRK11820 273068005512 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 273068005513 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 273068005514 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 273068005515 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 273068005516 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 273068005517 Pfam match to entry Dap_epimerase, Diaminopimelate epimerase, score 453, E-value 2.60E-132 273068005518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068005519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273068005520 putative substrate translocation pore; other site 273068005521 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 273068005522 Domain of unknown function (DUF814); Region: DUF814; pfam05670 273068005523 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 273068005524 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 273068005525 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 273068005526 Pfam match to entry 2_5_ligase, 2',5' RNA ligase family, score 44.3, E-value 2.70E-09 273068005527 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068005528 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 273068005529 Ligand Binding Site [chemical binding]; other site 273068005530 TIGR00269 family protein; Region: TIGR00269 273068005531 PUA domain; Region: PUA; cl00607 273068005532 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 273068005533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068005534 S-adenosylmethionine binding site [chemical binding]; other site 273068005535 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068005536 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 73.7, E-value 3.90E-18 273068005537 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068005538 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 94.7, E-value 1.90E-24 273068005539 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 273068005540 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 273068005541 heterodimer interface [polypeptide binding]; other site 273068005542 active site 273068005543 FMN binding site [chemical binding]; other site 273068005544 homodimer interface [polypeptide binding]; other site 273068005545 substrate binding site [chemical binding]; other site 273068005546 Pfam match to entry DHOdehase, Dihydroorotate dehydrogenase, score 323.8, E-value 2.00E-93 273068005547 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 273068005548 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 273068005549 FAD binding pocket [chemical binding]; other site 273068005550 FAD binding motif [chemical binding]; other site 273068005551 phosphate binding motif [ion binding]; other site 273068005552 beta-alpha-beta structure motif; other site 273068005553 NAD binding pocket [chemical binding]; other site 273068005554 Iron coordination center [ion binding]; other site 273068005555 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 273068005556 active site 273068005557 dimer interface [polypeptide binding]; other site 273068005558 dihydroorotase; Validated; Region: pyrC; PRK09357 273068005559 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 273068005560 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 273068005561 active site 273068005562 Pfam match to entry Dihydroorotase, Dihydroorotase-like, score 393.5, E-value 2.00E-114 273068005563 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 273068005564 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 273068005565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068005566 Pfam match to entry OTCace, Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain, score 101.6, E-value 5.30E-29 273068005567 Pfam match to entry OTCace_N, Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain, score 203.4, E-value 3.50E-57 273068005568 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068005569 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 81.5, E-value 1.70E-20 273068005570 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 273068005571 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 273068005572 dimerization interface [polypeptide binding]; other site 273068005573 putative ATP binding site [chemical binding]; other site 273068005574 Pfam match to entry AIRS, AIR synthase related protein, N-terminal domain, score 38.7, E-value 1.90E-09 273068005575 Pfam match to entry AIRS_C, AIR synthase related protein, C-terminal domain, score 61.6, E-value 3.30E-16 273068005576 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 273068005577 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273068005578 RNA binding surface [nucleotide binding]; other site 273068005579 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 273068005580 active site 273068005581 Pfam match to entry PseudoU_synth_2, RNA pseudouridylate synthase, score 265.7, E-value 6.30E-76 273068005582 Pfam match to entry S4, S4 domain, score 59.1, E-value 9.40E-14 273068005583 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 273068005584 Pfam match to entry Peptidase_A8, Signal peptidase (SPase) II, score 136.5, E-value 4.80E-37 273068005585 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 273068005586 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 273068005587 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 61, E-value 2.60E-14 273068005588 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068005589 active site 273068005590 NTP binding site [chemical binding]; other site 273068005591 metal binding triad [ion binding]; metal-binding site 273068005592 antibiotic binding site [chemical binding]; other site 273068005593 Pfam match to entry NTP_transf_2, Nucleotidyltransferase domain, score 44.8, E-value 1.90E-09 273068005594 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 273068005595 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 273068005596 Pfam match to entry Acetyltransf, Acetyltransferase (GNAT) family, score 60.3, E-value 4.20E-14 273068005597 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273068005598 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 273068005599 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 273068005600 Pfam match to entry Methylase_S, Type I restriction modification DNA specificity domain, score 111.3, E-value 5.80E-31 273068005601 Pfam match to entry Methylase_S, Type I restriction modification DNA specificity domain, score 41.8, E-value 7.00E-11 273068005602 RecG-like helicase [DNA replication, recombination, and repair / Transcription]; Region: RecG; COG1200 273068005603 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 273068005604 Uncharacterized conserved protein [Function unknown]; Region: COG3410 273068005605 HsdM N-terminal domain; Region: HsdM_N; pfam12161 273068005606 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 273068005607 Pfam match to entry N6_Mtase, N-6 DNA Methylase, score 44.3, E-value 2.50E-09 273068005608 Pfam match to entry Methylase_M, 'Type I restriction modification system, M', score -40.7, E-value 1.10E-06 273068005609 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 273068005610 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068005611 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 273068005612 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 273068005613 peptide binding site [polypeptide binding]; other site 273068005614 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 444.4, E-value 9.60E-130 273068005615 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 273068005616 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 273068005617 dimer interface [polypeptide binding]; other site 273068005618 FMN binding site [chemical binding]; other site 273068005619 Pfam match to entry Nitroreductase, Nitroreductase family, score 69.4, E-value 7.80E-17 273068005620 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068005621 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 273068005622 Pfam match to entry Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 33.9, E-value 3.70E-06 273068005623 Sigma factor regulator N-terminal; Region: Sigma_reg_N; pfam13800 273068005624 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 273068005625 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068005626 SERine Proteinase INhibitors (serpins), prokaryotic subgroup. Little information about specific functions is available for this subgroup, most likely they are inhibitory members of the serpin superfamily. In general, serpins exhibit conformational...; Region: bacterial_SERPIN; cd02049 273068005627 reactive center loop; other site 273068005628 Pfam match to entry serpin, Serpin (serine protease inhibitor), score 165.1, E-value 4.60E-48 273068005629 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 273068005630 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 273068005631 QueT transporter; Region: QueT; cl01932 273068005632 ThiC family; Region: ThiC; cl08031 273068005633 Pfam match to entry ThiC, ThiC family, score 929.8, E-value 7.40E-276 273068005634 RQC domain; Region: RQC; cl09632 273068005635 Uncharacterized conserved protein [Function unknown]; Region: COG4715 273068005636 SWIM zinc finger; Region: SWIM; cl15408 273068005637 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 273068005638 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 273068005639 NAD-dependent deacetylase; Provisional; Region: PRK14138 273068005640 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 273068005641 NAD+ binding site [chemical binding]; other site 273068005642 substrate binding site [chemical binding]; other site 273068005643 Zn binding site [ion binding]; other site 273068005644 Pfam match to entry Sir2, Sir2 family, score 308.9, E-value 6.10E-89 273068005645 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 273068005646 Pfam match to entry UPF0047, Uncharacterised protein family UPF0047, score 172.2, E-value 8.80E-48 273068005647 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 273068005648 Pfam match to entry zf_dskA_traR, Prokaryotic dksA/traR C4-type zinc finger, score 42.4, E-value 1.10E-08 273068005649 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 273068005650 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 273068005651 homodimer interface [polypeptide binding]; other site 273068005652 substrate-cofactor binding pocket; other site 273068005653 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068005654 catalytic residue [active] 273068005655 Pfam match to entry Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 620.6, E-value 8.80E-183 273068005656 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 273068005657 catalytic triad [active] 273068005658 Pfam match to entry AhpC-TSA, AhpC/TSA family, score 149, E-value 8.60E-41 273068005659 NeuB family; Region: NeuB; cl00496 273068005660 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 273068005661 Pfam match to entry DAHP_synth_1, DAHP synthetase I family, score 371.3, E-value 9.90E-108 273068005662 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 273068005663 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 273068005664 substrate binding site [chemical binding]; other site 273068005665 active site 273068005666 catalytic residues [active] 273068005667 heterodimer interface [polypeptide binding]; other site 273068005668 Pfam match to entry trp_syntA, Tryptophan synthase alpha chain, score 389.2, E-value 4.10E-113 273068005669 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 273068005670 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 273068005671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068005672 catalytic residue [active] 273068005673 Pfam match to entry PALP, Pyridoxal-phosphate dependent enzyme, score 465.3, E-value 5.00E-136 273068005674 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 273068005675 active site 273068005676 Pfam match to entry PRAI, N-(5'phosphoribosyl)anthranilate (PRA) isomerase, score 202.5, E-value 6.50E-57 273068005677 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 273068005678 active site 273068005679 ribulose/triose binding site [chemical binding]; other site 273068005680 phosphate binding site [ion binding]; other site 273068005681 substrate (anthranilate) binding pocket [chemical binding]; other site 273068005682 product (indole) binding pocket [chemical binding]; other site 273068005683 Pfam match to entry IGPS, Indole-3-glycerol phosphate synthase, score 351.3, E-value 1.00E-101 273068005684 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 273068005685 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 273068005686 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 273068005687 Pfam match to entry Glycos_transf_3, Glycosyl transferase family, a/b domain, score 436.4, E-value 2.60E-127 273068005688 Pfam match to entry Glycos_trans_3N, Glycosyl transferase family, helical bundle domain, score 89, E-value 9.60E-23 273068005689 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 273068005690 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 273068005691 glutamine binding [chemical binding]; other site 273068005692 catalytic triad [active] 273068005693 Pfam match to entry GATase, Glutamine amidotransferase class-I, score 295, E-value 9.30E-85 273068005694 anthranilate synthase component I; Provisional; Region: PRK13570 273068005695 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 273068005696 chorismate binding enzyme; Region: Chorismate_bind; cl10555 273068005697 Pfam match to entry chorismate_bind, chorismate binding enzyme, score 557.7, E-value 7.80E-164 273068005698 Domain of unknown function DUF77; Region: DUF77; cl00307 273068005699 Pfam match to entry DUF77, Protein of unknown function DUF77, score 101.6, E-value 1.50E-26 273068005700 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 273068005701 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 273068005702 homodimer interface [polypeptide binding]; other site 273068005703 substrate-cofactor binding pocket; other site 273068005704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068005705 catalytic residue [active] 273068005706 Pfam match to entry Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 628.3, E-value 4.20E-185 273068005707 QueT transporter; Region: QueT; cl01932 273068005708 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 273068005709 Pfam match to entry Mtap_PNP, Phosphorylase family 2, score 286.2, E-value 4.10E-82 273068005710 Cobalt transport protein; Region: CbiQ; cl00463 273068005711 Pfam match to entry CbiQ, Cobalt transport protein, score 118.3, E-value 1.50E-31 273068005712 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 273068005713 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 273068005714 Walker A/P-loop; other site 273068005715 ATP binding site [chemical binding]; other site 273068005716 Q-loop/lid; other site 273068005717 ABC transporter signature motif; other site 273068005718 Walker B; other site 273068005719 D-loop; other site 273068005720 H-loop/switch region; other site 273068005721 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 273068005722 Walker A/P-loop; other site 273068005723 ATP binding site [chemical binding]; other site 273068005724 Q-loop/lid; other site 273068005725 ABC transporter signature motif; other site 273068005726 Walker B; other site 273068005727 D-loop; other site 273068005728 H-loop/switch region; other site 273068005729 Pfam match to entry ABC_tran, ABC transporter, score 193.8, E-value 2.80E-54 273068005730 Pfam match to entry ABC_tran, ABC transporter, score 167, E-value 3.10E-46 273068005731 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 273068005732 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 273068005733 Pfam match to entry IF-2B, Initiation factor 2 subunit family, score 439.1, E-value 3.80E-128 273068005734 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR_like; cd08242 273068005735 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 273068005736 putative NAD(P) binding site [chemical binding]; other site 273068005737 catalytic Zn binding site [ion binding]; other site 273068005738 structural Zn binding site [ion binding]; other site 273068005739 Pfam match to entry adh_zinc, Zinc-binding dehydrogenases, score 121.9, E-value 1.20E-32 273068005740 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 273068005741 intersubunit interface [polypeptide binding]; other site 273068005742 active site 273068005743 Zn2+ binding site [ion binding]; other site 273068005744 Pfam match to entry Aldolase_II, Class II Aldolase and Adducin N-terminal domain., score 133.7, E-value 3.40E-36 273068005745 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 273068005746 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 273068005747 active site 273068005748 putative substrate binding pocket [chemical binding]; other site 273068005749 Pfam match to entry ATZ_TRZ, Chlorohydrolase, score 416.5, E-value 2.40E-121 273068005750 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 273068005751 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 273068005752 HIGH motif; other site 273068005753 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 273068005754 active site 273068005755 KMSKS motif; other site 273068005756 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 273068005757 tRNA binding surface [nucleotide binding]; other site 273068005758 anticodon binding site; other site 273068005759 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 273068005760 Pfam match to entry tRNA-synt_1, tRNA synthetases class I (I, L, M and V), score 1055.6, E-value 0 273068005761 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 273068005762 DivIVA protein; Region: DivIVA; pfam05103 273068005763 DivIVA domain; Region: DivI1A_domain; TIGR03544 273068005764 Mitochondrial ATP synthase B chain precursor (ATP-synt_B); Region: Mt_ATP-synt_B; cl07975 273068005765 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 273068005766 Protein of unknown function (DUF1062); Region: DUF1062; cl01786 273068005767 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273068005768 RNA binding surface [nucleotide binding]; other site 273068005769 Pfam match to entry S4, S4 domain, score 41.6, E-value 1.80E-08 273068005770 YGGT family; Region: YGGT; cl00508 273068005771 Protein of unknown function (DUF552); Region: DUF552; cl00775 273068005772 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 273068005773 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273068005774 catalytic residue [active] 273068005775 Pfam match to entry UPF0001, Uncharacterized protein family UPF0001, score 132.6, E-value 7.20E-36 273068005776 HlyD family secretion protein; Region: HlyD_2; pfam12700 273068005777 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 273068005778 putative membrane fusion protein; Region: TIGR02828 273068005779 tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238 273068005780 Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617 273068005781 substrate binding site [chemical binding]; other site 273068005782 tetramer interface [polypeptide binding]; other site 273068005783 catalytic residue [active] 273068005784 Pfam match to entry Beta_elim_lyase, Beta-eliminating lyase, score 1123.8, E-value 0 273068005785 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 273068005786 homotrimer interaction site [polypeptide binding]; other site 273068005787 putative active site [active] 273068005788 Pfam match to entry UPF0076, YjgF family, score 235.2, E-value 9.20E-67 273068005789 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 273068005790 Ferredoxin [Energy production and conversion]; Region: COG1146 273068005791 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 273068005792 Pfam match to entry fer4, 4Fe-4S binding domain, score 33.4, E-value 5.10E-06 273068005793 Pfam match to entry fer4, 4Fe-4S binding domain, score 30.2, E-value 4.80E-05 273068005794 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 273068005795 Pfam match to entry DUF183, Uncharacterized ACR, COG1984, score 360.2, E-value 2.20E-104 273068005796 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 273068005797 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 273068005798 Pfam match to entry DUF213, Uncharacterized ACR, COG2049, score 299.3, E-value 4.60E-86 273068005799 LamB/YcsF family; Region: LamB_YcsF; cl00664 273068005800 Protein of unknown function (DUF969); Region: DUF969; cl01573 273068005801 Protein of unknown function (DUF979); Region: DUF979; cl01572 273068005802 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 273068005803 putative substrate binding pocket [chemical binding]; other site 273068005804 AC domain interface; other site 273068005805 catalytic triad [active] 273068005806 AB domain interface; other site 273068005807 interchain disulfide; other site 273068005808 Pfam match to entry Peptidase_C15, Pyroglutamyl peptidase, score 376.5, E-value 2.70E-109 273068005809 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 273068005810 putative active site pocket [active] 273068005811 dimerization interface [polypeptide binding]; other site 273068005812 putative catalytic residue [active] 273068005813 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 273068005814 ligand binding site [chemical binding]; other site 273068005815 flexible hinge region; other site 273068005816 Helix-turn-helix domains; Region: HTH; cl00088 273068005817 Pfam match to entry crp, Bacterial regulatory proteins, crp family, score 36.3, E-value 2.00E-10 273068005818 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 273068005819 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 273068005820 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068005821 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 273068005822 Pfam match to entry NAD_Gly3P_dh, NAD-dependent glycerol-3-phosphate dehydrogenase, score 468, E-value 7.70E-137 273068005823 Domain of unknown function (DUF205); Region: DUF205; cl00410 273068005824 Pfam match to entry DUF205, Domain of unknown function DUF, score 221.6, E-value 1.20E-62 273068005825 GTP-binding protein Der; Reviewed; Region: PRK00093 273068005826 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 273068005827 G1 box; other site 273068005828 GTP/Mg2+ binding site [chemical binding]; other site 273068005829 Switch I region; other site 273068005830 G2 box; other site 273068005831 Switch II region; other site 273068005832 G3 box; other site 273068005833 G4 box; other site 273068005834 G5 box; other site 273068005835 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 273068005836 G1 box; other site 273068005837 GTP/Mg2+ binding site [chemical binding]; other site 273068005838 Switch I region; other site 273068005839 G2 box; other site 273068005840 G3 box; other site 273068005841 Switch II region; other site 273068005842 G4 box; other site 273068005843 G5 box; other site 273068005844 Pfam match to entry MMR_HSR1, GTPase of unknown function, score 252.6, E-value 5.50E-72 273068005845 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 273068005846 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 273068005847 Protein of unknown function (DUF512); Region: DUF512; pfam04459 273068005848 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 273068005849 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 273068005850 YIEGIA protein; Region: YIEGIA; pfam14045 273068005851 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 273068005852 stage II sporulation protein P; Region: spore_II_P; TIGR02867 273068005853 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 273068005854 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 273068005855 PhoU domain; Region: PhoU; pfam01895 273068005856 PhoU domain; Region: PhoU; pfam01895 273068005857 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 273068005858 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 273068005859 Walker A/P-loop; other site 273068005860 ATP binding site [chemical binding]; other site 273068005861 Q-loop/lid; other site 273068005862 ABC transporter signature motif; other site 273068005863 Walker B; other site 273068005864 D-loop; other site 273068005865 H-loop/switch region; other site 273068005866 Pfam match to entry ABC_tran, ABC transporter, score 205.3, E-value 9.40E-58 273068005867 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 273068005868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068005869 dimer interface [polypeptide binding]; other site 273068005870 conserved gate region; other site 273068005871 putative PBP binding loops; other site 273068005872 ABC-ATPase subunit interface; other site 273068005873 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 66.8, E-value 4.50E-16 273068005874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068005875 dimer interface [polypeptide binding]; other site 273068005876 conserved gate region; other site 273068005877 putative PBP binding loops; other site 273068005878 ABC-ATPase subunit interface; other site 273068005879 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 74, E-value 3.10E-18 273068005880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068005881 Pfam match to entry PstS, Phosphate-binding protein, score 257.3, E-value 2.10E-73 273068005882 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 273068005883 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068005884 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 273068005885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068005886 dimer interface [polypeptide binding]; other site 273068005887 phosphorylation site [posttranslational modification] 273068005888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068005889 ATP binding site [chemical binding]; other site 273068005890 Mg2+ binding site [ion binding]; other site 273068005891 G-X-G motif; other site 273068005892 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 183.4, E-value 3.80E-51 273068005893 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 89.5, E-value 6.60E-23 273068005894 Pfam match to entry PAS, PAS domain, score 29.8, E-value 1.20E-06 273068005895 Pfam match to entry HAMP, HAMP domain, score 41.5, E-value 1.90E-08 273068005896 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 273068005897 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068005898 active site 273068005899 phosphorylation site [posttranslational modification] 273068005900 intermolecular recognition site; other site 273068005901 dimerization interface [polypeptide binding]; other site 273068005902 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273068005903 DNA binding site [nucleotide binding] 273068005904 Pfam match to entry trans_reg_C, Transcriptional regulatory protein, C terminal, score 131.4, E-value 4.90E-38 273068005905 Pfam match to entry response_reg, Response regulator receiver domain, score 161.9, E-value 1.10E-44 273068005906 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 273068005907 ATP cone domain; Region: ATP-cone; pfam03477 273068005908 Pfam match to entry DUF193, Uncharacterized BCR, COG1327, score 272.8, E-value 4.50E-78 273068005909 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 273068005910 sporulation sigma factor SigG; Reviewed; Region: PRK08215 273068005911 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068005912 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273068005913 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068005914 DNA binding residues [nucleotide binding] 273068005915 Pfam match to entry sigma70, Sigma-70 factor, score 343.8, E-value 1.80E-99 273068005916 sporulation sigma factor SigE; Reviewed; Region: PRK08301 273068005917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068005918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068005919 DNA binding residues [nucleotide binding] 273068005920 Pfam match to entry sigma70, Sigma-70 factor, score 270.2, E-value 2.70E-77 273068005921 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 273068005922 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 273068005923 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 273068005924 nucleotide binding site [chemical binding]; other site 273068005925 SulA interaction site; other site 273068005926 Pfam match to entry tubulin, Tubulin/FtsZ family, score 95.9, E-value 8.10E-25 273068005927 cell division protein FtsA; Region: ftsA; TIGR01174 273068005928 Cell division protein FtsA; Region: FtsA; cl11496 273068005929 Cell division protein FtsA; Region: FtsA; cl11496 273068005930 Pfam match to entry FtsA, Cell division protein FtsA, score 452.4, E-value 3.80E-132 273068005931 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 273068005932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 273068005933 bZIP transcription factor; Region: bZIP_1; cl02576 273068005934 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 273068005935 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 273068005936 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 273068005937 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 273068005938 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 273068005939 hinge; other site 273068005940 active site 273068005941 Pfam match to entry EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 407.8, E-value 1.00E-118 273068005942 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 273068005943 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 273068005944 active site 273068005945 homodimer interface [polypeptide binding]; other site 273068005946 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 273068005947 Pfam match to entry FTSW_RODA_SPOVE, Cell cycle protein, score 497.1, E-value 1.40E-145 273068005948 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 273068005949 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 273068005950 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273068005951 Pfam match to entry Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 43, E-value 6.60E-09 273068005952 Pfam match to entry Mur_ligase, Mur ligase family, catalytic domain, score 195.6, E-value 7.30E-57 273068005953 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 273068005954 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 273068005955 Mg++ binding site [ion binding]; other site 273068005956 putative catalytic motif [active] 273068005957 putative substrate binding site [chemical binding]; other site 273068005958 Pfam match to entry Glycos_transf_4, Glycosyl transferase, score 205.5, E-value 7.90E-58 273068005959 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 273068005960 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273068005961 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 273068005962 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273068005963 Pfam match to entry Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 112.3, E-value 9.10E-30 273068005964 Pfam match to entry Mur_ligase, Mur ligase family, catalytic domain, score 263.1, E-value 8.30E-77 273068005965 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068005966 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 273068005967 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273068005968 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068005969 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 273068005970 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 273068005971 Pfam match to entry Transpeptidase, Penicillin binding protein transpeptidase domain, score 377.6, E-value 1.20E-109 273068005972 Septum formation initiator; Region: DivIC; cl11433 273068005973 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 273068005974 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068005975 Pfam match to entry Methyltransf_5, MraW methylase family, score 608, E-value 6.10E-182 273068005976 cell division protein MraZ; Reviewed; Region: PRK00326 273068005977 MraZ protein; Region: MraZ; pfam02381 273068005978 MraZ protein; Region: MraZ; pfam02381 273068005979 Pfam match to entry UPF0040, Domain of unknown function UPF0040 family, score 93.5, E-value 4.30E-24 273068005980 Pfam match to entry UPF0040, Domain of unknown function UPF0040 family, score 113.7, E-value 3.60E-30 273068005981 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 273068005982 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 273068005983 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273068005984 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 273068005985 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 273068005986 GTP-binding protein YchF; Reviewed; Region: PRK09601 273068005987 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 273068005988 G1 box; other site 273068005989 GTP/Mg2+ binding site [chemical binding]; other site 273068005990 Switch I region; other site 273068005991 G2 box; other site 273068005992 Switch II region; other site 273068005993 G3 box; other site 273068005994 G4 box; other site 273068005995 G5 box; other site 273068005996 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 273068005997 Pfam match to entry GTP1_OBG, GTP1/OBG family, score 24.5, E-value 9.20E-06 273068005998 Uncharacterized conserved protein [Function unknown]; Region: COG3595 273068005999 Protein of unknown function(DUF2089); Region: DUF2089; pfam09862 273068006000 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 273068006001 THUMP domain; Region: THUMP; cl12076 273068006002 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 273068006003 Ligand Binding Site [chemical binding]; other site 273068006004 Pfam match to entry ThiI, Thiamine biosynthesis protein (ThiI), score 380.7, E-value 1.50E-110 273068006005 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273068006006 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 273068006007 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273068006008 catalytic residue [active] 273068006009 Pfam match to entry aminotran_5, Aminotransferase class-V, score 401.9, E-value 6.10E-117 273068006010 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 273068006011 putative homotetramer interface [polypeptide binding]; other site 273068006012 putative homodimer interface [polypeptide binding]; other site 273068006013 putative allosteric switch controlling residues; other site 273068006014 putative metal binding site [ion binding]; other site 273068006015 putative homodimer-homodimer interface [polypeptide binding]; other site 273068006016 Pfam match to entry DUF156, Uncharacterized BCR, COG1937, score 42.1, E-value 1.30E-08 273068006017 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068006018 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 273068006019 Pfam match to entry 2-oxoacid_dh, 2-oxo acid dehydrogenases acyltransferase (catalytic domain), score 357.3, E-value 1.70E-103 273068006020 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068006021 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068006022 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 273068006023 catalytic residues [active] 273068006024 lipoyl synthase; Provisional; Region: PRK05481 273068006025 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068006026 FeS/SAM binding site; other site 273068006027 Pfam match to entry Lipoate_synth, Lipoate synthase, score 584.4, E-value 7.00E-172 273068006028 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 273068006029 Pfam match to entry Lipoate_B, Lipoate-protein ligase B, score 227.4, E-value 5.90E-90 273068006030 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 273068006031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006033 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273068006034 Pfam match to entry pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 188.6, E-value 1.00E-52 273068006035 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 347.6, E-value 1.40E-100 273068006036 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068006037 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068006038 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068006039 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068006040 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 273068006041 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 273068006042 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068006043 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 273068006044 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 273068006045 oligomer interface [polypeptide binding]; other site 273068006046 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 273068006047 putative active site [active] 273068006048 metal binding site [ion binding]; metal-binding site 273068006049 Pfam match to entry Peptidase_M18, Aminopeptidase I zinc metalloprotease (M18), score 439.4, E-value 3.30E-128 273068006050 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 273068006051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068006052 active site 273068006053 phosphorylation site [posttranslational modification] 273068006054 intermolecular recognition site; other site 273068006055 dimerization interface [polypeptide binding]; other site 273068006056 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273068006057 DNA binding residues [nucleotide binding] 273068006058 dimerization interface [polypeptide binding]; other site 273068006059 Pfam match to entry GerE, Bacterial regulatory proteins, luxR family, score 99.3, E-value 7.50E-26 273068006060 Pfam match to entry response_reg, Response regulator receiver domain, score 145.7, E-value 8.30E-40 273068006061 Sensor protein DegS; Region: DegS; pfam05384 273068006062 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 273068006063 Histidine kinase; Region: HisKA_3; pfam07730 273068006064 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 273068006065 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 46.4, E-value 1.80E-11 273068006066 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 273068006067 Protein of unknown function (DUF523); Region: DUF523; cl00733 273068006068 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 273068006069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068006070 Walker A/P-loop; other site 273068006071 ATP binding site [chemical binding]; other site 273068006072 Q-loop/lid; other site 273068006073 ABC transporter signature motif; other site 273068006074 Walker B; other site 273068006075 D-loop; other site 273068006076 H-loop/switch region; other site 273068006077 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 273068006078 Smr domain; Region: Smr; cl02619 273068006079 Pfam match to entry Smr, Smr domain, score 102.7, E-value 7.20E-27 273068006080 Pfam match to entry MutS_C, DNA mismatch repair proteins, mutS family, score 77.4, E-value 1.20E-20 273068006081 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 273068006082 Peptidase family U32; Region: Peptidase_U32; cl03113 273068006083 Collagenase; Region: DUF3656; pfam12392 273068006084 Peptidase family U32; Region: Peptidase_U32; cl03113 273068006085 Pfam match to entry Peptidase_U32, Peptidase family U32, score 311.9, E-value 7.40E-90 273068006086 Cell division protein ZapA; Region: ZapA; cl01146 273068006087 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 273068006088 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 273068006089 putative tRNA-binding site [nucleotide binding]; other site 273068006090 B3/4 domain; Region: B3_4; cl11458 273068006091 tRNA synthetase B5 domain; Region: B5; cl08394 273068006092 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 273068006093 dimer interface [polypeptide binding]; other site 273068006094 motif 1; other site 273068006095 motif 3; other site 273068006096 motif 2; other site 273068006097 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 273068006098 Pfam match to entry tRNA_bind, Putative tRNA binding domain, score 38.3, E-value 1.70E-07 273068006099 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 273068006100 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 273068006101 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 273068006102 dimer interface [polypeptide binding]; other site 273068006103 motif 1; other site 273068006104 active site 273068006105 motif 2; other site 273068006106 motif 3; other site 273068006107 Pfam match to entry tRNA-synt_2d, tRNA synthetases class II (F), score 406.6, E-value 2.30E-118 273068006108 Pfam match to entry tRNA-synt_2_N, Aminoacyl tRNA synthetase class II, N-terminal domain, score 87.4, E-value 2.90E-22 273068006109 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 273068006110 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 273068006111 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 273068006112 Pfam match to entry SpoU_methylase, SpoU rRNA Methylase family, score 112, E-value 1.20E-29 273068006113 ribosomal protein L20; Region: rpl20; CHL00068 273068006114 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 273068006115 23S rRNA binding site [nucleotide binding]; other site 273068006116 L21 binding site [polypeptide binding]; other site 273068006117 L13 binding site [polypeptide binding]; other site 273068006118 Pfam match to entry Ribosomal_L20, Ribosomal protein L20, score 227, E-value 2.90E-71 273068006119 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 273068006120 Pfam match to entry Ribosomal_L35p, Ribosomal protein L35, score 99.9, E-value 4.80E-26 273068006121 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 273068006122 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 273068006123 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 273068006124 Pfam match to entry IF3, Translation initiation factor IF-3, score 337.8, E-value 2.90E-112 273068006125 cobalt transport protein CbiM; Provisional; Region: PRK07331 273068006126 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 273068006127 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 273068006128 Pfam match to entry CbiM, CbiM, score 148.8, E-value 9.70E-41 273068006129 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 273068006130 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 273068006131 nickel binding site [ion binding]; other site 273068006132 Pfam match to entry HycI, Hydrogenase maturation protease, score 64.8, E-value 1.90E-15 273068006133 Formate hydrogenlyase maturation protein HycH; Region: HycH; cl06472 273068006134 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl15792 273068006135 Pfam match to entry oxidored_q6, NADH ubiquinone oxidoreductase, 20 Kd subunit, score 155.7, E-value 8.20E-43 273068006136 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 273068006137 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273068006138 Pfam match to entry fer4, 4Fe-4S binding domain, score 40.3, E-value 4.40E-08 273068006139 Pfam match to entry fer4, 4Fe-4S binding domain, score 41.9, E-value 1.40E-08 273068006140 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl15698 273068006141 Nickel-dependent hydrogenase; Region: NiFeSe_Hases; cl00417 273068006142 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; pfam00346 273068006143 Pfam match to entry complex1_49Kd, Respiratory-chain NADH dehydrogenase, 49 Kd subunit, score 53, E-value 6.60E-19 273068006144 Pfam match to entry NiFeSe_Hases, Nickel-dependent hydrogenase, score 32.7, E-value 1.60E-09 273068006145 Pfam match to entry complex1_30Kd, Respiratory-chain NADH dehydrogenase, 30 Kd subunit, score 41.9, E-value 5.20E-10 273068006146 hydrogenase 4 subunit D; Validated; Region: PRK06525 273068006147 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 273068006148 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 273068006149 Pfam match to entry oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 180.9, E-value 2.10E-50 273068006150 hydrogenase 4 subunit F; Validated; Region: PRK06458 273068006151 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 273068006152 Pfam match to entry oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 164, E-value 2.50E-45 273068006153 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 273068006154 NADH dehydrogenase; Region: NADHdh; cl00469 273068006155 Pfam match to entry NADHdh, NADH dehydrogenase, score 132.8, E-value 4.30E-36 273068006156 hydrogenase 4 subunit B; Validated; Region: PRK06521 273068006157 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 273068006158 Pfam match to entry oxidored_q1, NADH-Ubiquinone/plastoquinone (complex I), various chains, score 221, E-value 1.80E-62 273068006159 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 273068006160 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 273068006161 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 273068006162 ACS interaction site; other site 273068006163 CODH interaction site; other site 273068006164 cubane metal cluster (B-cluster) [ion binding]; other site 273068006165 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 273068006166 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 273068006167 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 273068006168 P-loop; other site 273068006169 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068006170 Pfam match to entry ParA, ParA family ATPase, score 47, E-value 4.20E-10 273068006171 Heme NO binding; Region: HNOB; cl15268 273068006172 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 273068006173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068006174 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 273068006175 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068006176 Walker A motif; other site 273068006177 ATP binding site [chemical binding]; other site 273068006178 Walker B motif; other site 273068006179 arginine finger; other site 273068006180 Helix-turn-helix domains; Region: HTH; cl00088 273068006181 Pfam match to entry sigma54, Sigma-54 interaction domain, score 483.3, E-value 1.90E-141 273068006182 Pfam match to entry V4R, V4R domain, score 57.8, E-value 2.40E-13 273068006183 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 273068006184 Tetramer interface [polypeptide binding]; other site 273068006185 active site 273068006186 FMN-binding site [chemical binding]; other site 273068006187 Pfam match to entry Chorismate_synt, Chorismate synthase, score 502.7, E-value 7.60E-153 273068006188 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068006189 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273068006190 putative substrate translocation pore; other site 273068006191 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 273068006192 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 273068006193 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 273068006194 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 273068006195 active site 273068006196 dimer interface [polypeptide binding]; other site 273068006197 motif 1; other site 273068006198 motif 2; other site 273068006199 motif 3; other site 273068006200 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 273068006201 anticodon binding site; other site 273068006202 Pfam match to entry tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 410.7, E-value 1.30E-119 273068006203 Pfam match to entry TGS, TGS domain, score 49.4, E-value 7.90E-11 273068006204 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068006205 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068006206 YtxC-like family; Region: YtxC; cl08500 273068006207 Response regulator receiver domain; Region: Response_reg; pfam00072 273068006208 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068006209 active site 273068006210 phosphorylation site [posttranslational modification] 273068006211 intermolecular recognition site; other site 273068006212 dimerization interface [polypeptide binding]; other site 273068006213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273068006214 metal binding site [ion binding]; metal-binding site 273068006215 active site 273068006216 I-site; other site 273068006217 Pfam match to entry GGDEF, GGDEF domain, score 13.8, E-value 7.40E-06 273068006218 Pfam match to entry response_reg, Response regulator receiver domain, score 140, E-value 4.20E-38 273068006219 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273068006220 catalytic residues [active] 273068006221 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 273068006222 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068006223 Transposase domain (DUF772); Region: DUF772; cl12084 273068006224 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 273068006225 aspartate racemase; Region: asp_race; TIGR00035 273068006226 Pfam match to entry Asp_Glu_race, Asp/Glu/Hydontoin racemase, score 39.2, E-value 1.30E-09 273068006227 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 273068006228 Pfam match to entry SDF, Sodium:dicarboxylate symporter family, score 54.4, E-value 1.70E-13 273068006229 Sodium:solute symporter family; Region: SSF; cl00456 273068006230 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 273068006231 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 273068006232 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 273068006233 dimerization interface [polypeptide binding]; other site 273068006234 domain crossover interface; other site 273068006235 redox-dependent activation switch; other site 273068006236 Pfam match to entry HSP33, Hsp33 protein, score 401.1, E-value 1.00E-116 273068006237 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 273068006238 DNA-binding site [nucleotide binding]; DNA binding site 273068006239 RNA-binding motif; other site 273068006240 Pfam match to entry CSD, 'Cold-shock' DNA-binding domain, score 145.6, E-value 8.80E-40 273068006241 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068006242 NAD-dependent deacetylase; Provisional; Region: PRK00481 273068006243 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 273068006244 NAD+ binding site [chemical binding]; other site 273068006245 substrate binding site [chemical binding]; other site 273068006246 Zn binding site [ion binding]; other site 273068006247 Pfam match to entry Sir2, Sir2 family, score 242, E-value 8.40E-69 273068006248 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 273068006249 NifU-like domain; Region: NifU; cl00484 273068006250 Pfam match to entry NifU-like, NifU-like domain, score 120.6, E-value 2.80E-32 273068006251 GAF domain; Region: GAF; cl15785 273068006252 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 273068006253 Pfam match to entry LGT, Prolipoprotein diacylglyceryl transferase, score 49.2, E-value 6.80E-11 273068006254 reverse gyrase; Reviewed; Region: PRK09401 273068006255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273068006256 ATP binding site [chemical binding]; other site 273068006257 TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove; Region: TOPRIM_TopoIA_RevGyr; cd03361 273068006258 active site 273068006259 putative interdomain interaction site [polypeptide binding]; other site 273068006260 putative metal-binding site [ion binding]; other site 273068006261 putative nucleotide binding site [chemical binding]; other site 273068006262 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 273068006263 domain I; other site 273068006264 DNA binding groove [nucleotide binding] 273068006265 phosphate binding site [ion binding]; other site 273068006266 domain II; other site 273068006267 domain III; other site 273068006268 nucleotide binding site [chemical binding]; other site 273068006269 catalytic site [active] 273068006270 domain IV; other site 273068006271 Pfam match to entry Toprim, Toprim domain, score 156.9, E-value 3.40E-43 273068006272 Pfam match to entry Topoisom_bac, DNA topoisomerase, score 183.6, E-value 3.10E-51 273068006273 dipeptidase PepV; Reviewed; Region: PRK07318 273068006274 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 273068006275 active site 273068006276 metal binding site [ion binding]; metal-binding site 273068006277 Pfam match to entry Peptidase_M20, Peptidase family M20/M25/M40, score 174.9, E-value 3.10E-49 273068006278 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 273068006279 Glyco_18 domain; Region: Glyco_18; smart00636 273068006280 active site 273068006281 spermine synthase; Region: PLN02823 273068006282 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068006283 S-adenosylmethionine binding site [chemical binding]; other site 273068006284 Pfam match to entry Spermine_synth, Spermine/spermidine synthase, score 151.8, E-value 1.20E-41 273068006285 Protein of unknown function DUF72; Region: DUF72; cl00777 273068006286 Pfam match to entry DUF72, Protein of unknown function DUF72, score 170.5, E-value 2.70E-47 273068006287 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 273068006288 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 273068006289 Pfam match to entry PMI_typeI, Phosphomannose isomerase type I, score -5.8, E-value 1.10E-08 273068006290 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 273068006291 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 273068006292 Pfam match to entry PNP_UDP_1, Phosphorylase family, score 383.7, E-value 1.90E-111 273068006293 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 273068006294 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 273068006295 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 273068006296 Pfam match to entry DUF34, Domain of unknown function DUF34, score 251, E-value 1.70E-71 273068006297 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 273068006298 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 273068006299 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 273068006300 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 273068006301 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068006302 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273068006303 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068006304 DNA binding residues [nucleotide binding] 273068006305 Pfam match to entry sigma70, Sigma-70 factor, score 494.2, E-value 1.00E-144 273068006306 DNA primase; Validated; Region: dnaG; PRK05667 273068006307 CHC2 zinc finger; Region: zf-CHC2; cl15369 273068006308 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 273068006309 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 273068006310 active site 273068006311 metal binding site [ion binding]; metal-binding site 273068006312 interdomain interaction site; other site 273068006313 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 273068006314 Pfam match to entry Toprim, Toprim domain, score 89.3, E-value 7.90E-23 273068006315 Pfam match to entry zf-CHC2, CHC2 zinc finger, score 193.6, E-value 3.10E-54 273068006316 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 273068006317 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068006318 Zn2+ binding site [ion binding]; other site 273068006319 Mg2+ binding site [ion binding]; other site 273068006320 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 273068006321 Pfam match to entry HD, HD domain, score 63.9, E-value 3.50E-15 273068006322 Preprotein translocase SecG subunit; Region: SecG; cl09123 273068006323 enolase; Provisional; Region: eno; PRK00077 273068006324 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 273068006325 dimer interface [polypeptide binding]; other site 273068006326 metal binding site [ion binding]; metal-binding site 273068006327 substrate binding pocket [chemical binding]; other site 273068006328 Pfam match to entry enolase, Enol-ase, score 880, E-value 7.20E-261 273068006329 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 273068006330 substrate binding site [chemical binding]; other site 273068006331 dimer interface [polypeptide binding]; other site 273068006332 catalytic triad [active] 273068006333 Pfam match to entry TIM, Triosephosphate isomerase, score 462.9, E-value 3.60E-149 273068006334 Phosphoglycerate kinase; Region: PGK; pfam00162 273068006335 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 273068006336 substrate binding site [chemical binding]; other site 273068006337 hinge regions; other site 273068006338 ADP binding site [chemical binding]; other site 273068006339 catalytic site [active] 273068006340 Pfam match to entry PGK, Phosphoglycerate kinase, score 814.8, E-value 3.10E-241 273068006341 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006342 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 273068006343 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl15856 273068006344 Pfam match to entry gpdh_C, Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain, score 381, E-value 1.20E-110 273068006345 Pfam match to entry gpdh, Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain, score 331.4, E-value 1.20E-136 273068006346 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 273068006347 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 273068006348 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 273068006349 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 273068006350 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 273068006351 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 273068006352 Pfam match to entry Sigma54_factors, Sigma-54 factors family, score 615.4, E-value 3.40E-181 273068006353 Acylphosphatase; Region: Acylphosphatase; cl00551 273068006354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068006355 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 273068006356 active site 273068006357 motif I; other site 273068006358 motif II; other site 273068006359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068006360 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068006361 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 61.4, E-value 2.00E-14 273068006362 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273068006363 metal binding site 2 [ion binding]; metal-binding site 273068006364 putative DNA binding helix; other site 273068006365 metal binding site 1 [ion binding]; metal-binding site 273068006366 dimer interface [polypeptide binding]; other site 273068006367 structural Zn2+ binding site [ion binding]; other site 273068006368 Pfam match to entry FUR, Ferric uptake regulator family, score 138, E-value 1.70E-37 273068006369 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 273068006370 VanW like protein; Region: VanW; pfam04294 273068006371 G5 domain; Region: G5; pfam07501 273068006372 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 273068006373 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 273068006374 minor groove reading motif; other site 273068006375 helix-hairpin-helix signature motif; other site 273068006376 substrate binding pocket [chemical binding]; other site 273068006377 active site 273068006378 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 273068006379 Pfam match to entry HhH-GPD, HhH-GPD superfamily base excision DNA repair protein, score 264.5, E-value 1.40E-75 273068006380 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 273068006381 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 273068006382 4Fe-4S binding domain; Region: Fer4; cl02805 273068006383 AAA domain; Region: AAA_32; pfam13654 273068006384 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 273068006385 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 273068006386 Pfam match to entry SASP, Small, acid-soluble spore proteins, alpha/beta type, score 40.3, E-value 9.20E-10 273068006387 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 273068006388 4Fe-4S binding domain; Region: Fer4; cl02805 273068006389 Helix-turn-helix domains; Region: HTH; cl00088 273068006390 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 273068006391 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068006392 FeS/SAM binding site; other site 273068006393 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068006394 Pfam match to entry MoaA_NifB_PqqE, moaA / nifB / pqqE family, score 49, E-value 1.00E-10 273068006395 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 273068006396 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068006397 dimerization interface [polypeptide binding]; other site 273068006398 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273068006399 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 273068006400 dimer interface [polypeptide binding]; other site 273068006401 putative CheW interface [polypeptide binding]; other site 273068006402 Cache domain; Region: Cache_1; pfam02743 273068006403 Pfam match to entry Cache, Cache domain, score 34.1, E-value 3.80E-08 273068006404 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 118.7, E-value 1.70E-32 273068006405 Pfam match to entry HAMP, HAMP domain, score 52.4, E-value 9.70E-12 273068006406 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 273068006407 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 273068006408 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 273068006409 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 273068006410 active site 273068006411 Pfam match to entry PRK, Phosphoribulokinase / Uridine kinase family, score 43.3, E-value 3.50E-11 273068006412 Radical SAM superfamily; Region: Radical_SAM; pfam04055 273068006413 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068006414 FeS/SAM binding site; other site 273068006415 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 273068006416 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 273068006417 active site 273068006418 Pfam match to entry PseudoU_synth_2, RNA pseudouridylate synthase, score 153.3, E-value 4.10E-42 273068006419 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 273068006420 nudix motif; other site 273068006421 Pfam match to entry mutT, MutT-like domain, score 81.7, E-value 1.50E-20 273068006422 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 273068006423 active site 273068006424 substrate-binding site [chemical binding]; other site 273068006425 metal-binding site [ion binding] 273068006426 ATP binding site [chemical binding]; other site 273068006427 Pfam match to entry PEPCK_ATP, Phosphoenolpyruvate carboxykinase, score 1059.4, E-value 0 273068006428 recombination factor protein RarA; Reviewed; Region: PRK13342 273068006429 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068006430 Walker A motif; other site 273068006431 ATP binding site [chemical binding]; other site 273068006432 Walker B motif; other site 273068006433 arginine finger; other site 273068006434 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 273068006435 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 57.4, E-value 3.10E-13 273068006436 HIRAN domain; Region: HIRAN; cl07418 273068006437 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068006438 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068006439 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068006440 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 87.4, E-value 3.00E-22 273068006441 Pfam match to entry Transposase_9, Transposase, score 52.6, E-value 8.50E-12 273068006442 short chain dehydrogenase; Provisional; Region: PRK06197 273068006443 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 273068006444 putative NAD(P) binding site [chemical binding]; other site 273068006445 active site 273068006446 Pfam match to entry adh_short, short chain dehydrogenase, score 122.1, E-value 1.00E-32 273068006447 Uncharacterized conserved protein [Function unknown]; Region: COG2128 273068006448 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 273068006449 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 273068006450 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 273068006451 active site 273068006452 nucleophile elbow; other site 273068006453 Peptidase family M48; Region: Peptidase_M48; cl12018 273068006454 Pfam match to entry Peptidase_M48, Peptidase family M48, score 140.4, E-value 3.20E-38 273068006455 LemA family; Region: LemA; cl00742 273068006456 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 273068006457 putative active site pocket [active] 273068006458 cleavage site 273068006459 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 273068006460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068006461 S-adenosylmethionine binding site [chemical binding]; other site 273068006462 Pfam match to entry DUF90, Domain of unknown function DUF90, score 34.7, E-value 2.20E-06 273068006463 subunit; Region: OAD_beta; cl00816 273068006464 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 273068006465 CotJB protein; Region: CotJB; pfam12652 273068006466 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 273068006467 dimanganese center [ion binding]; other site 273068006468 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 273068006469 putative deacylase active site [active] 273068006470 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 273068006471 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 273068006472 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 273068006473 Pterin binding enzyme; Region: Pterin_bind; pfam00809 273068006474 substrate binding pocket [chemical binding]; other site 273068006475 dimer interface [polypeptide binding]; other site 273068006476 inhibitor binding site; inhibition site 273068006477 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 273068006478 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 273068006479 B12 binding site [chemical binding]; other site 273068006480 Pfam match to entry B12-binding, B12 binding domain, score 134, E-value 2.80E-36 273068006481 Pfam match to entry B12-binding_2, B12 binding domain, score 55.2, E-value 1.40E-12 273068006482 Pfam match to entry S-methyl_trans, Homocysteine S-methyltransferase, score 221.1, E-value 1.60E-62 273068006483 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 273068006484 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 273068006485 FAD binding site [chemical binding]; other site 273068006486 Pfam match to entry MTHFR, Methylenetetrahydrofolate reductase, score 96.2, E-value 6.30E-25 273068006487 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 273068006488 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 273068006489 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 273068006490 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 273068006491 active site 273068006492 dimer interface [polypeptide binding]; other site 273068006493 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 273068006494 dimer interface [polypeptide binding]; other site 273068006495 active site 273068006496 Pfam match to entry PGI, Phosphoglucose isomerase, score 588.9, E-value 3.20E-173 273068006497 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 273068006498 putative FMN binding site [chemical binding]; other site 273068006499 Pfam match to entry Nitroreductase, Nitroreductase family, score 98.1, E-value 1.70E-25 273068006500 peptidase T; Region: peptidase-T; TIGR01882 273068006501 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 273068006502 metal binding site [ion binding]; metal-binding site 273068006503 dimer interface [polypeptide binding]; other site 273068006504 Pfam match to entry Peptidase_M20, Peptidase family M20/M25/M40, score 69.8, E-value 4.30E-19 273068006505 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 273068006506 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068006507 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 273068006508 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 273068006509 MatE; Region: MatE; cl10513 273068006510 MatE; Region: MatE; cl10513 273068006511 Pfam match to entry UPF0013, Uncharacterized membrane protein family UPF0013, score 145.6, E-value 8.60E-40 273068006512 Pfam match to entry UPF0013, Uncharacterized membrane protein family UPF0013, score 144.1, E-value 2.50E-39 273068006513 TRAM domain; Region: TRAM; cl01282 273068006514 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 273068006515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 273068006516 Pfam match to entry DUF90, Domain of unknown function DUF90, score 60, E-value 5.30E-14 273068006517 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 273068006518 Domain interface; other site 273068006519 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 273068006520 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 273068006521 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 273068006522 active site 273068006523 pyruvate kinase; Provisional; Region: PRK06354 273068006524 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 273068006525 domain interfaces; other site 273068006526 active site 273068006527 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 273068006528 Pfam match to entry PEP-utilizers, PEP-utilizing enzyme, mobile domain, score 115.5, E-value 1.00E-30 273068006529 Pfam match to entry PK_C, Pyruvate kinase, alpha/beta domain, score 138.2, E-value 1.50E-37 273068006530 Pfam match to entry PK, Pyruvate kinase, barrel domain, score 726.7, E-value 1.00E-214 273068006531 6-phosphofructokinase; Provisional; Region: PRK03202 273068006532 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 273068006533 active site 273068006534 ADP/pyrophosphate binding site [chemical binding]; other site 273068006535 dimerization interface [polypeptide binding]; other site 273068006536 allosteric effector site; other site 273068006537 fructose-1,6-bisphosphate binding site; other site 273068006538 Pfam match to entry PFK, Phosphofructokinase, score 541.8, E-value 4.40E-198 273068006539 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 273068006540 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 273068006541 RelB antitoxin; Region: RelB; cl01171 273068006542 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 273068006543 generic binding surface II; other site 273068006544 generic binding surface I; other site 273068006545 Pfam match to entry tRNA_anti, OB-fold nucleic acid binding domain, score 56.7, E-value 4.90E-13 273068006546 Pfam match to entry PHP_C, PHP domain C-terminal region, score 141.8, E-value 1.20E-38 273068006547 Pfam match to entry PHP_N, PHP domain N-terminal region, score 125.5, E-value 9.90E-34 273068006548 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 273068006549 Helix-turn-helix domains; Region: HTH; cl00088 273068006550 DNA-binding site [nucleotide binding]; DNA binding site 273068006551 DRTGG domain; Region: DRTGG; cl12147 273068006552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 273068006553 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 273068006554 active site 2 [active] 273068006555 active site 1 [active] 273068006556 Pfam match to entry CBS, CBS domain, score 40.7, E-value 3.30E-08 273068006557 Pfam match to entry CBS, CBS domain, score 41.6, E-value 1.80E-08 273068006558 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 273068006559 dimerization domain swap beta strand [polypeptide binding]; other site 273068006560 regulatory protein interface [polypeptide binding]; other site 273068006561 active site 273068006562 regulatory phosphorylation site [posttranslational modification]; other site 273068006563 Pfam match to entry PTS-HPr, PTS HPr component phosphorylation sites, score 148, E-value 1.50E-41 273068006564 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 273068006565 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 273068006566 Pfam match to entry DUF199, Uncharacterized BCR, COG1481, score 290.2, E-value 2.70E-83 273068006567 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068006568 maltodextrin glucosidase; Provisional; Region: PRK10785 273068006569 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 273068006570 homodimer interface [polypeptide binding]; other site 273068006571 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 273068006572 active site 273068006573 homodimer interface [polypeptide binding]; other site 273068006574 catalytic site [active] 273068006575 Pfam match to entry alpha-amylase, Alpha amylase, catalytic domain, score 472.1, E-value 4.60E-138 273068006576 Pfam match to entry alpha-amylase_N, Alpha amylase, N-terminal ig-like domain, score 209.7, E-value 4.40E-59 273068006577 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 273068006578 Helix-turn-helix domains; Region: HTH; cl00088 273068006579 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 273068006580 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 273068006581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 273068006582 CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989 273068006583 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 273068006584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068006585 dimer interface [polypeptide binding]; other site 273068006586 conserved gate region; other site 273068006587 putative PBP binding loops; other site 273068006588 ABC-ATPase subunit interface; other site 273068006589 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 69.5, E-value 7.10E-17 273068006590 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068006591 dimer interface [polypeptide binding]; other site 273068006592 conserved gate region; other site 273068006593 putative PBP binding loops; other site 273068006594 ABC-ATPase subunit interface; other site 273068006595 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 67.3, E-value 3.20E-16 273068006596 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 273068006597 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068006598 Pfam match to entry SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 252, E-value 8.00E-72 273068006599 Alpha amylase catalytic domain found in maltogenic amylases, cyclodextrin glycosyltransferase, and related proteins; Region: AmyAc_AmyMalt_CGTase_like; cd11320 273068006600 Ca binding site [ion binding]; other site 273068006601 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 273068006602 active site 273068006603 catalytic site [active] 273068006604 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 273068006605 Pfam match to entry alpha-amylase_C, Alpha amylase, C-terminal all-beta domain, score 26.9, E-value 1.30E-06 273068006606 Pfam match to entry alpha-amylase, Alpha amylase, catalytic domain, score 371.3, E-value 9.70E-108 273068006607 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 273068006608 Uncharacterized protein family UPF0052; Region: UPF0052; pfam01933 273068006609 phosphate binding site [ion binding]; other site 273068006610 putative substrate binding pocket [chemical binding]; other site 273068006611 dimer interface [polypeptide binding]; other site 273068006612 Pfam match to entry UPF0052, Uncharacterised protein family UPF0052, score 459.1, E-value 3.60E-134 273068006613 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 273068006614 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068006615 putative hydrolase; Validated; Region: PRK09248 273068006616 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 273068006617 Pfam match to entry PHP_C, PHP domain C-terminal region, score 40, E-value 5.30E-08 273068006618 Pfam match to entry PHP_N, PHP domain N-terminal region, score 75.5, E-value 1.10E-18 273068006619 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 273068006620 FAD binding domain; Region: FAD_binding_4; pfam01565 273068006621 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 273068006622 Pfam match to entry MurB_C, UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain, score 179, E-value 7.80E-50 273068006623 Pfam match to entry MurB, UDP-N-acetylenolpyruvoylglucosamine reductase, FAD-binding domain, score 218.1, E-value 1.30E-61 273068006624 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 273068006625 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 273068006626 active site 273068006627 nucleophile elbow; other site 273068006628 Pfam match to entry UPF0028, Uncharacterized protein family UPF0028, score 39.6, E-value 2.80E-12 273068006629 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 273068006630 Helix-turn-helix domains; Region: HTH; cl00088 273068006631 Pfam match to entry tetR, Bacterial regulatory proteins, tetR family, score 67.4, E-value 3.00E-16 273068006632 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 273068006633 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cl15691 273068006634 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 273068006635 active site 273068006636 ATP binding site [chemical binding]; other site 273068006637 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 273068006638 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 273068006639 catalytic triad [active] 273068006640 conserved cis-peptide bond; other site 273068006641 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 273068006642 CoenzymeA binding site [chemical binding]; other site 273068006643 subunit interaction site [polypeptide binding]; other site 273068006644 PHB binding site; other site 273068006645 Pfam match to entry DUF157, Uncharacterized protein PaaI, COG2050, score 103.2, E-value 5.10E-27 273068006646 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 273068006647 Pfam match to entry DedA, DedA family, score 120.5, E-value 3.00E-32 273068006648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 273068006649 Pfam match to entry DUF134, Protein of unknown function DUF134, score 118.1, E-value 1.70E-31 273068006650 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 273068006651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068006652 FeS/SAM binding site; other site 273068006653 Pfam match to entry Radical_activat, Radical activating enzyme, score 51.9, E-value 1.40E-11 273068006654 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 273068006655 ATP cone domain; Region: ATP-cone; pfam03477 273068006656 Class III ribonucleotide reductase; Region: RNR_III; cd01675 273068006657 effector binding site; other site 273068006658 active site 273068006659 Zn binding site [ion binding]; other site 273068006660 glycine loop; other site 273068006661 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 273068006662 metal binding site 2 [ion binding]; metal-binding site 273068006663 putative DNA binding helix; other site 273068006664 metal binding site 1 [ion binding]; metal-binding site 273068006665 dimer interface [polypeptide binding]; other site 273068006666 structural Zn2+ binding site [ion binding]; other site 273068006667 Pfam match to entry FUR, Ferric uptake regulator family, score 100.6, E-value 3.00E-26 273068006668 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 273068006669 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 273068006670 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 273068006671 G1 box; other site 273068006672 GTP/Mg2+ binding site [chemical binding]; other site 273068006673 Switch I region; other site 273068006674 G2 box; other site 273068006675 G3 box; other site 273068006676 Switch II region; other site 273068006677 G4 box; other site 273068006678 G5 box; other site 273068006679 Nucleoside recognition; Region: Gate; cl00486 273068006680 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 273068006681 Nucleoside recognition; Region: Gate; cl00486 273068006682 Pfam match to entry FeoB, Ferrous iron transport protein B, score 271, E-value 1.60E-77 273068006683 Helix-turn-helix domains; Region: HTH; cl00088 273068006684 FeoA domain; Region: FeoA; cl00838 273068006685 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 273068006686 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 273068006687 G1 box; other site 273068006688 GTP/Mg2+ binding site [chemical binding]; other site 273068006689 Switch I region; other site 273068006690 G2 box; other site 273068006691 G3 box; other site 273068006692 Switch II region; other site 273068006693 G4 box; other site 273068006694 G5 box; other site 273068006695 Nucleoside recognition; Region: Gate; cl00486 273068006696 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 273068006697 Nucleoside recognition; Region: Gate; cl00486 273068006698 Pfam match to entry FeoB, Ferrous iron transport protein B, score 1080.7, E-value 0 273068006699 FeoA domain; Region: FeoA; cl00838 273068006700 FeoA domain; Region: FeoA; cl00838 273068006701 ABC-2 type transporter; Region: ABC2_membrane; cl11417 273068006702 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273068006703 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 273068006704 Walker A/P-loop; other site 273068006705 ATP binding site [chemical binding]; other site 273068006706 Q-loop/lid; other site 273068006707 ABC transporter signature motif; other site 273068006708 Walker B; other site 273068006709 D-loop; other site 273068006710 H-loop/switch region; other site 273068006711 Pfam match to entry ABC_tran, ABC transporter, score 192.3, E-value 7.50E-54 273068006712 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 273068006713 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 273068006714 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 273068006715 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 273068006716 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 273068006717 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 273068006718 Pfam match to entry FwdE, Tungsten formylmethanofuran dehydrogenase, subunit E, FwdE, score 166.5, E-value 4.50E-46 273068006719 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 273068006720 homodimer interaction site [polypeptide binding]; other site 273068006721 cofactor binding site; other site 273068006722 Pfam match to entry UPF0066, Uncharacterised protein family UPF0066, score 156.5, E-value 4.50E-43 273068006723 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 273068006724 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 273068006725 Walker A/P-loop; other site 273068006726 ATP binding site [chemical binding]; other site 273068006727 Q-loop/lid; other site 273068006728 ABC transporter signature motif; other site 273068006729 Walker B; other site 273068006730 D-loop; other site 273068006731 H-loop/switch region; other site 273068006732 Pfam match to entry ABC_tran, ABC transporter, score 182.4, E-value 7.40E-51 273068006733 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 273068006734 ABC-ATPase subunit interface; other site 273068006735 dimer interface [polypeptide binding]; other site 273068006736 putative PBP binding regions; other site 273068006737 Pfam match to entry FecCD_family, FecCD transport family, score 417.1, E-value 1.60E-121 273068006738 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 273068006739 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 273068006740 putative metal binding site [ion binding]; other site 273068006741 Pfam match to entry Peripla_BP_2, Periplasmic binding protein, score 140, E-value 4.40E-38 273068006742 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 273068006743 selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475 273068006744 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 273068006745 G1 box; other site 273068006746 putative GEF interaction site [polypeptide binding]; other site 273068006747 GTP/Mg2+ binding site [chemical binding]; other site 273068006748 Switch I region; other site 273068006749 G2 box; other site 273068006750 G3 box; other site 273068006751 Switch II region; other site 273068006752 G4 box; other site 273068006753 G5 box; other site 273068006754 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 273068006755 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 273068006756 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 273068006757 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 273068006758 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 200.5, E-value 2.60E-56 273068006759 seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474 273068006760 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 273068006761 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273068006762 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 273068006763 dimerization interface [polypeptide binding]; other site 273068006764 putative ATP binding site [chemical binding]; other site 273068006765 Pfam match to entry AIRS_C, AIR synthase related protein, C-terminal domain, score 77.7, E-value 9.20E-21 273068006766 Pfam match to entry AIRS, AIR synthase related protein, N-terminal domain, score 80.3, E-value 5.40E-21 273068006767 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 273068006768 Pfam match to entry FA_synthesis, Fatty acid synthesis protein, score 106.1, E-value 6.80E-28 273068006769 'initiating' condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are characterized by the...; Region: init_cond_enzymes; cd00827 273068006770 dimer interface [polypeptide binding]; other site 273068006771 active site 273068006772 Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338 273068006773 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273068006774 catalytic residues [active] 273068006775 Pfam match to entry thiored, Thioredoxin, score 75.7, E-value 1.70E-21 273068006776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006777 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 273068006778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006779 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 272, E-value 8.00E-78 273068006780 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 273068006781 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 273068006782 CPxP motif; other site 273068006783 DsrE/DsrF-like family; Region: DrsE; cl00672 273068006784 Pfam match to entry UPF0033, Uncharacterized protein family UPF0033, score 44.6, E-value 2.20E-09 273068006785 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 273068006786 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006787 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273068006788 Pfam match to entry pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 58.6, E-value 1.30E-13 273068006789 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 247, E-value 2.50E-70 273068006790 biotin synthase; Provisional; Region: PRK07094 273068006791 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068006792 FeS/SAM binding site; other site 273068006793 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 273068006794 Pfam match to entry Biotin_synth, Biotin synthase, score -53.4, E-value 1.30E-11 273068006795 methyl coenzyme M reductase system, component A2; Region: met_CoM_red_A2; TIGR03269 273068006796 4Fe-4S binding domain; Region: Fer4; cl02805 273068006797 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273068006798 4Fe-4S binding domain; Region: Fer4; cl02805 273068006799 Pfam match to entry fer4, 4Fe-4S binding domain, score 39.7, E-value 6.70E-08 273068006800 Pfam match to entry fer4, 4Fe-4S binding domain, score 41.5, E-value 1.90E-08 273068006801 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 273068006802 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068006803 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 273068006804 Pfam match to entry DUF153, Uncharacterized ACR, COG1433, score 90.2, E-value 4.30E-23 273068006805 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 273068006806 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 273068006807 P loop nucleotide binding; other site 273068006808 switch II; other site 273068006809 Pfam match to entry ParA, ParA family ATPase, score 50.6, E-value 3.50E-11 273068006810 Pfam match to entry fer4, 4Fe-4S binding domain, score 31.9, E-value 1.50E-05 273068006811 Pfam match to entry fer4, 4Fe-4S binding domain, score 38.3, E-value 1.70E-07 273068006812 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 273068006813 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 273068006814 switch II; other site 273068006815 nitrogenase reductase-like protein; Reviewed; Region: PRK13230 273068006816 Pfam match to entry ParA, ParA family ATPase, score 46.7, E-value 5.30E-10 273068006817 Pfam match to entry fer4, 4Fe-4S binding domain, score 30.8, E-value 3.10E-05 273068006818 Pfam match to entry fer4, 4Fe-4S binding domain, score 39.5, E-value 7.50E-08 273068006819 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 273068006820 Pfam match to entry DUF153, Uncharacterized ACR, COG1433, score 85.2, E-value 1.30E-21 273068006821 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068006822 Methyltransferase domain; Region: Methyltransf_31; pfam13847 273068006823 S-adenosylmethionine binding site [chemical binding]; other site 273068006824 Predicted methyltransferases [General function prediction only]; Region: COG1568 273068006825 Pfam match to entry DUF43, Protein of unknown function DUF43, score 488.1, E-value 6.90E-143 273068006826 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 273068006827 G1 box; other site 273068006828 GTP/Mg2+ binding site [chemical binding]; other site 273068006829 Switch I region; other site 273068006830 G2 box; other site 273068006831 Switch II region; other site 273068006832 G3 box; other site 273068006833 G4 box; other site 273068006834 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 273068006835 G5 box; other site 273068006836 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 273068006837 Ligand Binding Site [chemical binding]; other site 273068006838 Pfam match to entry Usp, Universal stress protein family, score 58.4, E-value 1.60E-13 273068006839 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 273068006840 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 273068006841 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 273068006842 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 273068006843 Walker A/P-loop; other site 273068006844 ATP binding site [chemical binding]; other site 273068006845 Q-loop/lid; other site 273068006846 ABC transporter signature motif; other site 273068006847 Walker B; other site 273068006848 D-loop; other site 273068006849 H-loop/switch region; other site 273068006850 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273068006851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068006852 Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571 273068006853 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 273068006854 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 273068006855 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068006856 Walker A/P-loop; other site 273068006857 ATP binding site [chemical binding]; other site 273068006858 Q-loop/lid; other site 273068006859 ABC transporter signature motif; other site 273068006860 Walker B; other site 273068006861 D-loop; other site 273068006862 H-loop/switch region; other site 273068006863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068006864 Pfam match to entry ABC_tran, ABC transporter, score 212.9, E-value 4.80E-60 273068006865 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273068006866 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068006867 Walker A/P-loop; other site 273068006868 ATP binding site [chemical binding]; other site 273068006869 Q-loop/lid; other site 273068006870 ABC transporter signature motif; other site 273068006871 Walker B; other site 273068006872 D-loop; other site 273068006873 H-loop/switch region; other site 273068006874 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068006875 Pfam match to entry ABC_tran, ABC transporter, score 214.9, E-value 1.20E-60 273068006876 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273068006877 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273068006878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068006879 dimer interface [polypeptide binding]; other site 273068006880 conserved gate region; other site 273068006881 putative PBP binding loops; other site 273068006882 ABC-ATPase subunit interface; other site 273068006883 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 38.7, E-value 1.30E-07 273068006884 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273068006885 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068006886 dimer interface [polypeptide binding]; other site 273068006887 conserved gate region; other site 273068006888 putative PBP binding loops; other site 273068006889 ABC-ATPase subunit interface; other site 273068006890 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 42.4, E-value 1.00E-08 273068006891 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 273068006892 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 273068006893 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 307, E-value 2.30E-88 273068006894 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 273068006895 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273068006896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068006897 Pfam match to entry Transpeptidase, Penicillin binding protein transpeptidase domain, score 410.9, E-value 1.20E-119 273068006898 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068006899 Pfam match to entry SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 51.2, E-value 2.20E-11 273068006900 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 273068006901 active site 273068006902 intersubunit interactions; other site 273068006903 catalytic residue [active] 273068006904 Pfam match to entry Transaldolase, Transaldolase, score 311.1, E-value 3.40E-92 273068006905 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 273068006906 sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968 273068006907 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068006908 Walker A/P-loop; other site 273068006909 ATP binding site [chemical binding]; other site 273068006910 Q-loop/lid; other site 273068006911 ABC transporter signature motif; other site 273068006912 Walker B; other site 273068006913 D-loop; other site 273068006914 H-loop/switch region; other site 273068006915 Pfam match to entry ABC_tran, ABC transporter, score 23.5, E-value 3.50E-07 273068006916 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 273068006917 Amino acid permease; Region: AA_permease; cl00524 273068006918 Pfam match to entry aa_permeases, Amino acid permease, score -113.2, E-value 2.00E-08 273068006919 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 273068006920 Amino acid permease; Region: AA_permease; cl00524 273068006921 Pfam match to entry aa_permeases, Amino acid permease, score -161.1, E-value 1.20E-06 273068006922 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 273068006923 Helix-turn-helix domains; Region: HTH; cl00088 273068006924 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273068006925 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068006926 Pfam match to entry ROK, ROK family, score 167.7, E-value 8.70E-49 273068006927 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 273068006928 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 273068006929 NAD binding site [chemical binding]; other site 273068006930 homodimer interface [polypeptide binding]; other site 273068006931 active site 273068006932 substrate binding site [chemical binding]; other site 273068006933 Pfam match to entry 3Beta_HSD, 3-beta hydroxysteroid dehydrogenase/isomera, score -99.1, E-value 1.00E-05 273068006934 Pfam match to entry Epimerase, NAD dependent epimerase/dehydratase family, score 530.2, E-value 1.40E-155 273068006935 galactokinase; Provisional; Region: PRK05322 273068006936 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 273068006937 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 273068006938 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273068006939 Pfam match to entry GHMP_kinases, GHMP kinases putative ATP-binding protein, score 78.8, E-value 7.40E-21 273068006940 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 273068006941 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 273068006942 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 273068006943 Pfam match to entry GalP_UDP_tr_C, Galactose-1-phosphate uridyl transferase, C-terminal domain, score 223.4, E-value 3.40E-63 273068006944 Pfam match to entry GalP_UDP_transf, Galactose-1-phosphate uridyl transferase, N-terminal domain, score 159.4, E-value 7.60E-49 273068006945 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 273068006946 putative active site [active] 273068006947 Pfam match to entry Glyco_hydro_20, 'Glycosyl hydrolase family 20, catalyti', score -117, E-value 7.90E-07 273068006948 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 273068006949 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 273068006950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068006951 putative substrate translocation pore; other site 273068006952 Pfam match to entry Na_Galacto_symp, Sodium:galactoside symporter family, score -38.9, E-value 9.00E-06 273068006953 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 273068006954 Pfam match to entry DUF158, Uncharacterized LmbE-like protein, COG2120, score 86.7, E-value 4.70E-22 273068006955 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 273068006956 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 273068006957 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 273068006958 putative active site [active] 273068006959 putative catalytic site [active] 273068006960 Pfam match to entry Glyco_hydro_31, Glycosyl hydrolases family 31, score 263.9, E-value 7.70E-77 273068006961 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 273068006962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068006963 dimer interface [polypeptide binding]; other site 273068006964 conserved gate region; other site 273068006965 putative PBP binding loops; other site 273068006966 ABC-ATPase subunit interface; other site 273068006967 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 79.8, E-value 5.50E-20 273068006968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068006969 dimer interface [polypeptide binding]; other site 273068006970 conserved gate region; other site 273068006971 putative PBP binding loops; other site 273068006972 ABC-ATPase subunit interface; other site 273068006973 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 68.6, E-value 1.30E-16 273068006974 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273068006975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068006976 Pfam match to entry SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 200.2, E-value 3.20E-56 273068006977 Glucuronate isomerase; Region: UxaC; cl00829 273068006978 Pfam match to entry UxaC, Glucuronate isomerase, score 1039.4, E-value 0 273068006979 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 273068006980 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 273068006981 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 273068006982 Pfam match to entry Mannitol_dh, Mannitol dehydrogenase, score 96.7, E-value 1.30E-27 273068006983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006984 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 273068006985 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 273068006986 Pfam match to entry 6PGD, 6-phosphogluconate dehydrogenase, score 741.3, E-value 4.20E-219 273068006987 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 273068006988 gluconate kinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 273068006989 N- and C-terminal domain interface [polypeptide binding]; other site 273068006990 putative active site [active] 273068006991 catalytic site [active] 273068006992 metal binding site [ion binding]; metal-binding site 273068006993 carbohydrate binding site [chemical binding]; other site 273068006994 ATP binding site [chemical binding]; other site 273068006995 Pfam match to entry FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 143.6, E-value 3.10E-39 273068006996 Pfam match to entry FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score 151.8, E-value 1.20E-41 273068006997 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 273068006998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068006999 Pfam match to entry 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 230.8, E-value 2.00E-65 273068007000 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273068007001 Helix-turn-helix domains; Region: HTH; cl00088 273068007002 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 273068007003 Pfam match to entry deoR, Bacterial regulatory proteins, deoR family, score 289.6, E-value 3.90E-83 273068007004 glyoxylate reductase; Reviewed; Region: PRK13243 273068007005 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007006 Pfam match to entry 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 262.6, E-value 5.40E-75 273068007007 Pfam match to entry 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 61.4, E-value 2.00E-14 273068007008 Membrane transport protein; Region: Mem_trans; cl09117 273068007009 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 273068007010 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 273068007011 Metal-binding active site; metal-binding site 273068007012 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 273068007013 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273068007014 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007015 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 273068007016 Pfam match to entry GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 129.7, E-value 5.30E-35 273068007017 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273068007018 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007019 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 273068007020 Pfam match to entry GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 149.4, E-value 6.10E-41 273068007021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273068007022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068007023 DNA binding site [nucleotide binding] 273068007024 domain linker motif; other site 273068007025 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 273068007026 dimerization interface [polypeptide binding]; other site 273068007027 ligand binding site [chemical binding]; other site 273068007028 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 121.1, E-value 2.10E-32 273068007029 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 44.2, E-value 4.70E-11 273068007030 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 273068007031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068007032 FeS/SAM binding site; other site 273068007033 hypothetical protein; Provisional; Region: PRK03881 273068007034 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 273068007035 AMMECR1; Region: AMMECR1; cl00911 273068007036 Pfam match to entry DUF51, Protein of unknown function DUF51, score 64.5, E-value 2.30E-15 273068007037 Pfam match to entry LigB, Catalytic LigB subunit of aromatic ring-opening dioxygenase, score 10.6, E-value 3.00E-08 273068007038 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068007039 active site 273068007040 NTP binding site [chemical binding]; other site 273068007041 metal binding triad [ion binding]; metal-binding site 273068007042 antibiotic binding site [chemical binding]; other site 273068007043 Pfam match to entry NTP_transf_2, Nucleotidyltransferase domain, score 48, E-value 2.00E-10 273068007044 HEPN domain; Region: HEPN; cl00824 273068007045 Protein of unknown function, DUF624; Region: DUF624; cl02369 273068007046 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 273068007047 AMP-binding enzyme; Region: AMP-binding; cl15778 273068007048 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 273068007049 Pfam match to entry AMP-binding, AMP-binding enzyme, score 204, E-value 2.30E-57 273068007050 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 273068007051 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068007052 Pfam match to entry ROK, ROK family, score 193.5, E-value 1.80E-56 273068007053 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068007054 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068007055 putative hydrolase; Validated; Region: PRK09248 273068007056 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 273068007057 Pfam match to entry PHP_C, PHP domain C-terminal region, score 55, E-value 1.60E-12 273068007058 Pfam match to entry PHP_N, PHP domain N-terminal region, score 55.8, E-value 9.30E-13 273068007059 HPr kinase/phosphorylase; Provisional; Region: PRK05428 273068007060 DRTGG domain; Region: DRTGG; cl12147 273068007061 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 273068007062 Hpr binding site; other site 273068007063 active site 273068007064 homohexamer subunit interaction site [polypeptide binding]; other site 273068007065 Pfam match to entry Hpr_kinase, Hpr Serine kinase, score 404.1, E-value 1.30E-117 273068007066 Helix-turn-helix domains; Region: HTH; cl00088 273068007067 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 273068007068 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 273068007069 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 273068007070 Pfam match to entry BPL, Biotin protein ligase catalytic domain, score 205.6, E-value 7.50E-58 273068007071 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 273068007072 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 273068007073 GIY-YIG motif/motif A; other site 273068007074 active site 273068007075 catalytic site [active] 273068007076 putative DNA binding site [nucleotide binding]; other site 273068007077 metal binding site [ion binding]; metal-binding site 273068007078 UvrB/uvrC motif; Region: UVR; pfam02151 273068007079 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 273068007080 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 273068007081 Pfam match to entry HHH, Helix-hairpin-helix motif., score 23.1, E-value 0.0067 273068007082 Pfam match to entry UVR, UvrB/uvrC motif, score 44.1, E-value 3.10E-09 273068007083 Pfam match to entry Exci_endo_N, Endo/excinuclease amino terminal domain, score 137.7, E-value 2.20E-37 273068007084 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 273068007085 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 273068007086 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 273068007087 Pfam match to entry Transpeptidase, Penicillin binding protein transpeptidase domain, score 290, E-value 3.00E-83 273068007088 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 273068007089 Pfam match to entry FTSW_RODA_SPOVE, Cell cycle protein, score 243.4, E-value 3.10E-69 273068007090 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 273068007091 phosphopeptide binding site; other site 273068007092 Pfam match to entry FHA, FHA domain, score 102.5, E-value 8.10E-27 273068007093 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 273068007094 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 273068007095 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 273068007096 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 273068007097 Pfam match to entry ABC_tran, ABC transporter, score 117, E-value 3.50E-31 273068007098 Pfam match to entry ABC_tran, ABC transporter, score 17.4, E-value 1.00E-06 273068007099 excinuclease ABC subunit B; Provisional; Region: PRK05298 273068007100 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273068007101 ATP binding site [chemical binding]; other site 273068007102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273068007103 nucleotide binding region [chemical binding]; other site 273068007104 ATP-binding site [chemical binding]; other site 273068007105 Ultra-violet resistance protein B; Region: UvrB; pfam12344 273068007106 UvrB/uvrC motif; Region: UVR; pfam02151 273068007107 Pfam match to entry UVR, UvrB/uvrC motif, score 46.8, E-value 4.90E-10 273068007108 Pfam match to entry helicase_C, Helicase conserved C-terminal domain, score 86.3, E-value 6.30E-22 273068007109 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 273068007110 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 273068007111 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273068007112 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068007113 C-terminal peptidase (prc); Region: prc; TIGR00225 273068007114 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 273068007115 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 273068007116 Catalytic dyad [active] 273068007117 Pfam match to entry PDZ, PDZ domain (Also known as DHR or GLGF)., score 67.6, E-value 2.60E-16 273068007118 FemAB family; Region: FemAB; cl11444 273068007119 USP8 interacting; Region: USP8_interact; pfam08941 273068007120 Peptidase family M23; Region: Peptidase_M23; pfam01551 273068007121 Pfam match to entry Peptidase_M37, Peptidase family M23/M37, score 159.1, E-value 7.50E-44 273068007122 FtsX-like permease family; Region: FtsX; cl15850 273068007123 Pfam match to entry DUF214, Predicted permease, score 57.1, E-value 3.70E-13 273068007124 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 273068007125 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 273068007126 Walker A/P-loop; other site 273068007127 ATP binding site [chemical binding]; other site 273068007128 Q-loop/lid; other site 273068007129 ABC transporter signature motif; other site 273068007130 Walker B; other site 273068007131 D-loop; other site 273068007132 H-loop/switch region; other site 273068007133 Pfam match to entry ABC_tran, ABC transporter, score 234.4, E-value 1.70E-66 273068007134 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 273068007135 Helix-turn-helix domains; Region: HTH; cl00088 273068007136 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 273068007137 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 273068007138 Walker A/P-loop; other site 273068007139 ATP binding site [chemical binding]; other site 273068007140 Q-loop/lid; other site 273068007141 ABC transporter signature motif; other site 273068007142 Walker B; other site 273068007143 D-loop; other site 273068007144 H-loop/switch region; other site 273068007145 Pfam match to entry ABC_tran, ABC transporter, score 217.9, E-value 1.50E-61 273068007146 diaminopimelate decarboxylase; Region: lysA; TIGR01048 273068007147 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 273068007148 active site 273068007149 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273068007150 substrate binding site [chemical binding]; other site 273068007151 catalytic residues [active] 273068007152 dimer interface [polypeptide binding]; other site 273068007153 Pfam match to entry Orn_Arg_deC_N, Pyridoxal-dependent decarboxylase, pyridoxal binding domain, score 241.8, E-value 1.20E-70 273068007154 Pfam match to entry Orn_Dap_Arg_deC, Pyridoxal-dependent decarboxylase, C-terminal sheet domain, score 137.7, E-value 9.00E-38 273068007155 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 273068007156 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 273068007157 5S rRNA interface [nucleotide binding]; other site 273068007158 CTC domain interface [polypeptide binding]; other site 273068007159 L16 interface [polypeptide binding]; other site 273068007160 Pfam match to entry Ribosomal_L25p, Ribosomal L25p family, score 87.1, E-value 3.50E-22 273068007161 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 273068007162 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068007163 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068007164 motif II; other site 273068007165 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 120.9, E-value 2.40E-32 273068007166 transposase, putative, N-terminal domain; Region: tspaseT_teng_N; TIGR01765 273068007167 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 273068007168 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 273068007169 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068007170 active site 273068007171 NTP binding site [chemical binding]; other site 273068007172 metal binding triad [ion binding]; metal-binding site 273068007173 antibiotic binding site [chemical binding]; other site 273068007174 Pfam match to entry NTP_transf_2, Nucleotidyltransferase domain, score 42.8, E-value 7.90E-09 273068007175 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 273068007176 Cell division protein FtsA; Region: FtsA; cl11496 273068007177 Cell division protein FtsA; Region: FtsA; cl11496 273068007178 Pfam match to entry FtsA, Cell division protein FtsA, score -62.2, E-value 4.30E-08 273068007179 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068007180 Pfam match to entry BcrAD_BadFG, BadF/BadG/BcrA/BcrD ATPase family, score 226.7, E-value 3.40E-64 273068007181 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068007182 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 273068007183 Walker A motif; other site 273068007184 ATP binding site [chemical binding]; other site 273068007185 Walker B motif; other site 273068007186 arginine finger; other site 273068007187 Peptidase family M41; Region: Peptidase_M41; pfam01434 273068007188 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 313.9, E-value 1.90E-90 273068007189 Pfam match to entry Peptidase_M41, Peptidase family M41, score 278.3, E-value 1.00E-79 273068007190 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 273068007191 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 273068007192 DAK2 domain; Region: Dak2; cl03685 273068007193 Pfam match to entry Dak2, Dak2 domain, score 175.7, E-value 7.50E-49 273068007194 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 273068007195 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 273068007196 Pfam match to entry Dak1, Dak1 domain, score 528.5, E-value 4.70E-155 273068007197 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 273068007198 dimerization domain swap beta strand [polypeptide binding]; other site 273068007199 regulatory protein interface [polypeptide binding]; other site 273068007200 active site 273068007201 regulatory phosphorylation site [posttranslational modification]; other site 273068007202 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 273068007203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068007204 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 273068007205 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068007206 Walker A motif; other site 273068007207 ATP binding site [chemical binding]; other site 273068007208 Walker B motif; other site 273068007209 arginine finger; other site 273068007210 Helix-turn-helix domains; Region: HTH; cl00088 273068007211 Pfam match to entry sigma54, Sigma-54 interaction domain, score 533.5, E-value 1.50E-156 273068007212 Pfam match to entry PAS, PAS domain, score 37.4, E-value 9.20E-09 273068007213 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 273068007214 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 273068007215 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007216 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 107.8, E-value 2.20E-28 273068007217 Predicted dehydrogenase [General function prediction only]; Region: COG0579 273068007218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007219 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 273068007220 Pfam match to entry FAD_Gly3P_dh, FAD-dependent glycerol-3-phosphate dehyd, score -155.5, E-value 2.30E-07 273068007221 glycerol kinase; Provisional; Region: glpK; PRK00047 273068007222 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 273068007223 N- and C-terminal domain interface [polypeptide binding]; other site 273068007224 active site 273068007225 MgATP binding site [chemical binding]; other site 273068007226 catalytic site [active] 273068007227 metal binding site [ion binding]; metal-binding site 273068007228 glycerol binding site [chemical binding]; other site 273068007229 homotetramer interface [polypeptide binding]; other site 273068007230 homodimer interface [polypeptide binding]; other site 273068007231 FBP binding site [chemical binding]; other site 273068007232 protein IIAGlc interface [polypeptide binding]; other site 273068007233 Pfam match to entry FGGY_C, FGGY family of carbohydrate kinases, C-terminal domain, score 341.9, E-value 7.00E-99 273068007234 Pfam match to entry FGGY, FGGY family of carbohydrate kinases, N-terminal domain, score 423, E-value 2.70E-123 273068007235 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 273068007236 amphipathic channel; other site 273068007237 Asn-Pro-Ala signature motifs; other site 273068007238 Pfam match to entry MIP, Major intrinsic protein, score 200.7, E-value 1.20E-64 273068007239 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 273068007240 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 273068007241 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 273068007242 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 273068007243 NodB motif; other site 273068007244 active site 273068007245 catalytic site [active] 273068007246 Cd binding site [ion binding]; other site 273068007247 Pfam match to entry Polysac_deacet, Polysaccharide deacetylase, score 188.6, E-value 1.00E-52 273068007248 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 273068007249 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 273068007250 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 273068007251 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 273068007252 Ligand Binding Site [chemical binding]; other site 273068007253 Pfam match to entry KdpD, Osmosensitive K+ channel His kinase sensor domain, score 483.8, E-value 1.30E-141 273068007254 K+-transporting ATPase, c chain; Region: KdpC; cl00944 273068007255 Pfam match to entry KdpC, K+-transporting ATPase, c chain, score 188, E-value 1.50E-52 273068007256 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 273068007257 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273068007258 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068007259 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 123.3, E-value 4.40E-33 273068007260 Pfam match to entry E1-E2_ATPase, E1-E2 ATPase, score 188.5, E-value 3.40E-56 273068007261 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 273068007262 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 273068007263 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 273068007264 active site 273068007265 Substrate binding site; other site 273068007266 Mg++ binding site; other site 273068007267 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 273068007268 putative CoA binding site [chemical binding]; other site 273068007269 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 273068007270 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 273068007271 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 273068007272 active site 273068007273 substrate binding site [chemical binding]; other site 273068007274 metal binding site [ion binding]; metal-binding site 273068007275 Pfam match to entry NTP_transferase, Nucleotidyl transferase, score 183.1, E-value 4.40E-51 273068007276 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 273068007277 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 273068007278 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 273068007279 Pfam match to entry Na_Pi_cotrans, Na+/Pi-cotransporter, score 35.6, E-value 2.60E-09 273068007280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068007281 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068007282 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068007283 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068007284 CHC2 zinc finger; Region: zf-CHC2; cl15369 273068007285 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 273068007286 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 273068007287 active site 273068007288 metal binding site [ion binding]; metal-binding site 273068007289 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068007290 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 273068007291 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 273068007292 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 273068007293 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 273068007294 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 273068007295 Pfam match to entry DUF79, Protein of unknown function DUF79, score 40.7, E-value 3.20E-08 273068007296 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 273068007297 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007298 Walker A/P-loop; other site 273068007299 ATP binding site [chemical binding]; other site 273068007300 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 273068007301 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 273068007302 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273068007303 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 273068007304 Pfam match to entry S1, S1 RNA binding domain, score 23.6, E-value 6.30E-05 273068007305 Pfam match to entry S1, S1 RNA binding domain, score 30.5, E-value 7.80E-07 273068007306 ParB-like partition proteins; Region: parB_part; TIGR00180 273068007307 ParB-like nuclease domain; Region: ParBc; cl02129 273068007308 Pfam match to entry ParBc, ParB-like nuclease domain, score 46.8, E-value 4.90E-10 273068007309 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 273068007310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007311 Walker A motif; other site 273068007312 ATP binding site [chemical binding]; other site 273068007313 Walker B motif; other site 273068007314 Pfam match to entry TRAG, TraG/TraD family, score 137, E-value 3.40E-37 273068007315 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068007316 non-specific DNA binding site [nucleotide binding]; other site 273068007317 salt bridge; other site 273068007318 sequence-specific DNA binding site [nucleotide binding]; other site 273068007319 Pfam match to entry HTH_3, Helix-turn-helix, score 53.5, E-value 4.50E-12 273068007320 PRTRC system protein D; Region: PRTRC_D; TIGR03739 273068007321 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273068007322 dimer interface [polypeptide binding]; other site 273068007323 ssDNA binding site [nucleotide binding]; other site 273068007324 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273068007325 Pfam match to entry SSB, Single-strand binding protein family, score 125.5, E-value 2.80E-36 273068007326 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 273068007327 Helix-turn-helix domains; Region: HTH; cl00088 273068007328 Helix-turn-helix domains; Region: HTH; cl00088 273068007329 Pfam match to entry HTH_3, Helix-turn-helix, score 37.6, E-value 2.90E-07 273068007330 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 273068007331 Zn2+ binding site [ion binding]; other site 273068007332 Mg2+ binding site [ion binding]; other site 273068007333 Pfam match to entry HD, HD domain, score 55.6, E-value 1.10E-12 273068007334 Region: SpoVG; cl00915 273068007335 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 273068007336 AAA domain; Region: AAA_31; pfam13614 273068007337 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007338 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 273068007339 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 273068007340 Type II secretion system (T2SS), protein F; Region: T2SF; cl00906 273068007341 ParB-like partition proteins; Region: parB_part; TIGR00180 273068007342 ParB-like nuclease domain; Region: ParBc; cl02129 273068007343 Pfam match to entry ParBc, ParB-like nuclease domain, score 55.2, E-value 1.40E-12 273068007344 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 273068007345 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 273068007346 Walker A motif; other site 273068007347 hexamer interface [polypeptide binding]; other site 273068007348 ATP binding site [chemical binding]; other site 273068007349 Walker B motif; other site 273068007350 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 273068007351 SAF domain; Region: SAF; cl00555 273068007352 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 273068007353 PPIC-type PPIASE domain; Region: Rotamase; cl08278 273068007354 ParB-like partition proteins; Region: parB_part; TIGR00180 273068007355 ParB-like nuclease domain; Region: ParBc; cl02129 273068007356 phosphodiesterase; Provisional; Region: PRK12704 273068007357 Pfam match to entry ParBc, ParB-like nuclease domain, score 50.3, E-value 4.30E-11 273068007358 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 273068007359 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 273068007360 S-layer homology domain; Region: SLH; pfam00395 273068007361 S-layer homology domain; Region: SLH; pfam00395 273068007362 Pfam match to entry SLH, S-layer homology domain, score 40.2, E-value 4.50E-08 273068007363 Pfam match to entry SLH, S-layer homology domain, score 40.4, E-value 4.10E-08 273068007364 Peptidase family M23; Region: Peptidase_M23; pfam01551 273068007365 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 273068007366 N-acetyl-D-glucosamine binding site [chemical binding]; other site 273068007367 catalytic residue [active] 273068007368 Pfam match to entry SLT, Transglycosylase SLT domain, score 65, E-value 1.60E-15 273068007369 Pfam match to entry Peptidase_M37, Peptidase family M23/M37, score 156.7, E-value 3.90E-43 273068007370 Transposase [DNA replication, recombination, and repair]; Region: COG5421 273068007371 AAA-like domain; Region: AAA_10; pfam12846 273068007372 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007373 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 273068007374 PrgI family protein; Region: PrgI; pfam12666 273068007375 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 273068007376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068007377 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 273068007378 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068007379 DNA binding residues [nucleotide binding] 273068007380 Pfam match to entry sigma70, Sigma-70 factor, score 267.2, E-value 2.10E-76 273068007381 Recombination protein U; Region: RecU; cl01314 273068007382 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 273068007383 DHH family; Region: DHH; pfam01368 273068007384 DHHA1 domain; Region: DHHA1; pfam02272 273068007385 Pfam match to entry DHH, DHH family, score 133.7, E-value 3.30E-36 273068007386 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 273068007387 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007388 Family description; Region: UvrD_C_2; cl15862 273068007389 Pfam match to entry Viral_helicase1, Viral (Superfamily 1) RNA helicase, score 22.1, E-value 1.20E-05 273068007390 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 273068007391 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 273068007392 putative homodimer interface [polypeptide binding]; other site 273068007393 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 273068007394 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 273068007395 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068007396 non-specific DNA binding site [nucleotide binding]; other site 273068007397 salt bridge; other site 273068007398 sequence-specific DNA binding site [nucleotide binding]; other site 273068007399 Pfam match to entry HTH_3, Helix-turn-helix, score 51.3, E-value 2.10E-11 273068007400 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068007401 non-specific DNA binding site [nucleotide binding]; other site 273068007402 salt bridge; other site 273068007403 sequence-specific DNA binding site [nucleotide binding]; other site 273068007404 Pfam match to entry HTH_3, Helix-turn-helix, score 63.2, E-value 5.60E-15 273068007405 Domain of unknown function (DUF955); Region: DUF955; cl01076 273068007406 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 273068007407 Phage integrase family; Region: Phage_integrase; pfam00589 273068007408 Int/Topo IB signature motif; other site 273068007409 Pfam match to entry Phage_integrase, Phage integrase family, score 121.5, E-value 1.60E-32 273068007410 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 273068007411 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 273068007412 active site 273068007413 dimer interface [polypeptide binding]; other site 273068007414 Pfam match to entry Renal_dipeptase, Renal dipeptidase, score 56, E-value 8.10E-13 273068007415 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 273068007416 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 273068007417 dimer interface [polypeptide binding]; other site 273068007418 glycine-pyridoxal phosphate binding site [chemical binding]; other site 273068007419 active site 273068007420 folate binding site [chemical binding]; other site 273068007421 Pfam match to entry SHMT, Serine hydroxymethyltransferase, score 893.6, E-value 4.10E-268 273068007422 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 273068007423 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 273068007424 active site 273068007425 FMN binding site [chemical binding]; other site 273068007426 substrate binding site [chemical binding]; other site 273068007427 putative catalytic residue [active] 273068007428 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007430 Pfam match to entry oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase family, score 503.4, E-value 1.70E-147 273068007431 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 136.4, E-value 5.30E-37 273068007432 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 273068007433 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 273068007434 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 273068007435 Pfam match to entry PRA-PH, Phosphoribosyl-ATP pyrophosphohydrolase, score 159.1, E-value 7.50E-44 273068007436 Pfam match to entry PRA-CH, Phosphoribosyl-AMP cyclohydrolase, score 186.6, E-value 4.10E-52 273068007437 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 273068007438 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 273068007439 substrate binding site [chemical binding]; other site 273068007440 glutamase interaction surface [polypeptide binding]; other site 273068007441 Pfam match to entry His_biosynth, Histidine biosynthesis protein, score 498.7, E-value 4.40E-146 273068007442 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 273068007443 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 273068007444 catalytic residues [active] 273068007445 Pfam match to entry His_biosynth, Histidine biosynthesis protein, score 219, E-value 7.20E-62 273068007446 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 273068007447 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 273068007448 putative active site [active] 273068007449 oxyanion strand; other site 273068007450 catalytic triad [active] 273068007451 Pfam match to entry GATase, Glutamine amidotransferase class-I, score 176.7, E-value 3.80E-49 273068007452 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 273068007453 putative active site pocket [active] 273068007454 4-fold oligomerization interface [polypeptide binding]; other site 273068007455 metal binding residues [ion binding]; metal-binding site 273068007456 3-fold/trimer interface [polypeptide binding]; other site 273068007457 Pfam match to entry IGPD, Imidazoleglycerol-phosphate dehydratase, score 293.4, E-value 6.20E-100 273068007458 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 273068007459 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273068007460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068007461 homodimer interface [polypeptide binding]; other site 273068007462 catalytic residue [active] 273068007463 Pfam match to entry aminotran_1, Aminotransferase class-I, score -25.9, E-value 1.60E-08 273068007464 Pfam match to entry aminotran_2, Aminotransferase class-II, score 141.2, E-value 1.90E-38 273068007465 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 273068007466 histidinol dehydrogenase; Region: hisD; TIGR00069 273068007467 NAD binding site [chemical binding]; other site 273068007468 dimerization interface [polypeptide binding]; other site 273068007469 product binding site; other site 273068007470 substrate binding site [chemical binding]; other site 273068007471 zinc binding site [ion binding]; other site 273068007472 catalytic residues [active] 273068007473 Pfam match to entry Histidinol_dh, Histidinol dehydrogenase, score 793.6, E-value 7.30E-235 273068007474 ATP phosphoribosyltransferase; Region: HisG; cl15266 273068007475 Pfam match to entry HisG, ATP phosphoribosyltransferase, score 258.2, E-value 1.10E-73 273068007476 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 273068007477 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 273068007478 dimer interface [polypeptide binding]; other site 273068007479 motif 1; other site 273068007480 active site 273068007481 motif 2; other site 273068007482 motif 3; other site 273068007483 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068007484 active site 273068007485 NTP binding site [chemical binding]; other site 273068007486 metal binding triad [ion binding]; metal-binding site 273068007487 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 273068007488 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 273068007489 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 273068007490 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 273068007491 ABC-2 type transporter; Region: ABC2_membrane; cl11417 273068007492 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 273068007493 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007494 Walker A/P-loop; other site 273068007495 ATP binding site [chemical binding]; other site 273068007496 Q-loop/lid; other site 273068007497 ABC transporter signature motif; other site 273068007498 Walker B; other site 273068007499 D-loop; other site 273068007500 H-loop/switch region; other site 273068007501 Pfam match to entry ABC_tran, ABC transporter, score 182.7, E-value 5.70E-51 273068007502 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 273068007503 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 273068007504 Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091 273068007505 Putative carbohydrate binding domain; Region: CBM_X; cl05621 273068007506 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 273068007507 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 273068007508 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 273068007509 Putative carbohydrate binding domain; Region: CBM_X; cl05621 273068007510 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 273068007511 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 273068007512 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 273068007513 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 273068007514 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068007515 S-adenosylmethionine binding site [chemical binding]; other site 273068007516 Uncharacterized conserved protein [Function unknown]; Region: COG3270 273068007517 Pfam match to entry Nol1_Nop2_Sun, NOL1/NOP2/sun family, score 165.2, E-value 4.30E-47 273068007518 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273068007519 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007520 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 273068007521 Pfam match to entry GFO_IDH_MocA_C, Oxidoreductase family, C-terminal alpha/beta domain, score 36.9, E-value 4.50E-07 273068007522 Pfam match to entry GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 31.3, E-value 7.20E-06 273068007523 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 273068007524 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 273068007525 homodimer interface [polypeptide binding]; other site 273068007526 substrate-cofactor binding pocket; other site 273068007527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068007528 catalytic residue [active] 273068007529 Pfam match to entry Cys_Met_Meta_PP, Cys/Met metabolism PLP-dependent enzyme, score 798.6, E-value 2.40E-236 273068007530 homoserine dehydrogenase; Provisional; Region: PRK06349 273068007531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007532 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 273068007533 Pfam match to entry Homoserine_dh, Homoserine dehydrogenase, score 249.5, E-value 4.50E-71 273068007534 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 273068007535 Rubredoxin; Region: Rubredoxin; pfam00301 273068007536 iron binding site [ion binding]; other site 273068007537 Pfam match to entry rubredoxin, Rubredoxin, score 121.2, E-value 2.70E-33 273068007538 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 273068007539 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 273068007540 Ligand Binding Site [chemical binding]; other site 273068007541 Pfam match to entry KdpD, Osmosensitive K+ channel His kinase sensor domain, score 521.1, E-value 8.20E-153 273068007542 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 273068007543 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 273068007544 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 273068007545 Uncharacterized conserved protein [Function unknown]; Region: COG1284 273068007546 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 273068007547 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 273068007548 Pfam match to entry DUF161, Uncharacterized BCR, YitT family COG1284, score 167.1, E-value 2.90E-46 273068007549 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 273068007550 catalytic residues [active] 273068007551 catalytic nucleophile [active] 273068007552 Pfam match to entry resolvase, Resolvase class of site-specific recombinases, score 25.4, E-value 1.40E-06 273068007553 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 273068007554 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 273068007555 PemK-like protein; Region: PemK; cl00995 273068007556 Pfam match to entry PemK, PemK-like protein, score 181.5, E-value 1.40E-50 273068007557 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 273068007558 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 273068007559 Pfam match to entry HTH_4, Helix-turn-helix protein, copG family, score 36.1, E-value 8.60E-09 273068007560 alanine racemase; Reviewed; Region: alr; PRK00053 273068007561 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 273068007562 active site 273068007563 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 273068007564 dimer interface [polypeptide binding]; other site 273068007565 substrate binding site [chemical binding]; other site 273068007566 catalytic residues [active] 273068007567 Pfam match to entry Ala_racemase, Alanine racemase, score 482.4, E-value 3.60E-141 273068007568 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 273068007569 putative carbohydrate kinase; Provisional; Region: PRK10565 273068007570 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 273068007571 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 273068007572 putative substrate binding site [chemical binding]; other site 273068007573 putative ATP binding site [chemical binding]; other site 273068007574 Pfam match to entry UPF0031, Uncharacterized protein family UPF0031, score 226.7, E-value 3.40E-64 273068007575 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 273068007576 Pfam match to entry ACPS, 4'-phosphopantetheinyl transferase superfamily, score 138.5, E-value 1.20E-37 273068007577 Helix-turn-helix domains; Region: HTH; cl00088 273068007578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068007579 non-specific DNA binding site [nucleotide binding]; other site 273068007580 salt bridge; other site 273068007581 sequence-specific DNA binding site [nucleotide binding]; other site 273068007582 Pfam match to entry HTH_3, Helix-turn-helix, score 55.1, E-value 1.50E-12 273068007583 Protein of unknown function (DUF503); Region: DUF503; cl00669 273068007584 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 273068007585 putative active site [active] 273068007586 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 273068007587 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068007588 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068007589 DNA binding residues [nucleotide binding] 273068007590 Pfam match to entry Sigma70_ECF, Sigma-70 factor (ECF subfamily), score 89.3, E-value 7.70E-23 273068007591 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 273068007592 Double zinc ribbon; Region: DZR; pfam12773 273068007593 zinc-ribbon domain; Region: zf-ribbon_3; cl11198 273068007594 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273068007595 The ABCA subfamily mediates the transport of a variety of lipid compounds. Mutations of members of ABCA subfamily are associated with human genetic diseases, such as, familial high-density lipoprotein (HDL) deficiency, neonatal surfactant deficiency; Region: ABC_subfamily_A; cd03263 273068007596 Walker A/P-loop; other site 273068007597 ATP binding site [chemical binding]; other site 273068007598 Q-loop/lid; other site 273068007599 ABC transporter signature motif; other site 273068007600 Walker B; other site 273068007601 D-loop; other site 273068007602 H-loop/switch region; other site 273068007603 Pfam match to entry ABC_tran, ABC transporter, score 184.3, E-value 2.00E-51 273068007604 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 273068007605 Domain of unknown function DUF; Region: DUF204; pfam02659 273068007606 peroxiredoxin; Provisional; Region: PRK13189 273068007607 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 273068007608 dimer interface [polypeptide binding]; other site 273068007609 decamer (pentamer of dimers) interface [polypeptide binding]; other site 273068007610 catalytic triad [active] 273068007611 Pfam match to entry AhpC-TSA, AhpC/TSA family, score 178.3, E-value 1.30E-49 273068007612 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 273068007613 Pfam match to entry UPF0047, Uncharacterised protein family UPF0047, score 235.6, E-value 6.90E-67 273068007614 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 273068007615 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 273068007616 glutaminase active site [active] 273068007617 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 273068007618 dimer interface [polypeptide binding]; other site 273068007619 active site 273068007620 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 273068007621 dimer interface [polypeptide binding]; other site 273068007622 active site 273068007623 Pfam match to entry SIS, SIS domain, score 116.3, E-value 5.80E-31 273068007624 Pfam match to entry SIS, SIS domain, score 161, E-value 2.10E-44 273068007625 Pfam match to entry GATase_2, Glutamine amidotransferases class-II, score 253.6, E-value 6.80E-86 273068007626 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 273068007627 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 273068007628 active site 273068007629 substrate binding site [chemical binding]; other site 273068007630 metal binding site [ion binding]; metal-binding site 273068007631 Pfam match to entry PGM_PMM, Phosphoglucomutase/phosphomannomutase, C-terminal domain, score 41.3, E-value 2.20E-08 273068007632 Pfam match to entry PGM_PMM_III, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III, score 103.1, E-value 5.50E-27 273068007633 Pfam match to entry PGM_PMM_II, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II, score 117.3, E-value 2.90E-31 273068007634 Pfam match to entry PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 164.9, E-value 1.30E-45 273068007635 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 273068007636 putative acyl-acceptor binding pocket; other site 273068007637 Pfam match to entry Acyltransferase, Acyltransferase, score 117.6, E-value 2.40E-31 273068007638 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 273068007639 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 273068007640 Pfam match to entry POR, Pyruvate ferredoxin/flavodoxin oxidoreductase, score 137, E-value 3.40E-37 273068007641 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 273068007642 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273068007643 dimer interface [polypeptide binding]; other site 273068007644 PYR/PP interface [polypeptide binding]; other site 273068007645 TPP binding site [chemical binding]; other site 273068007646 substrate binding site [chemical binding]; other site 273068007647 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 273068007648 TPP-binding site; other site 273068007649 Pfam match to entry POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductas, score -26, E-value 2.80E-06 273068007650 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 273068007651 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 273068007652 Pfam match to entry PTA_PTB, Phosphate acetyl/butaryl transferase, score 196.7, E-value 3.70E-55 273068007653 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 273068007654 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 273068007655 dimer interface [polypeptide binding]; other site 273068007656 PYR/PP interface [polypeptide binding]; other site 273068007657 TPP binding site [chemical binding]; other site 273068007658 substrate binding site [chemical binding]; other site 273068007659 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 273068007660 Pfam match to entry POR_N, Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-binding domain, score 235.9, E-value 5.60E-67 273068007661 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 273068007662 Pfam match to entry fer4, 4Fe-4S binding domain, score 33.5, E-value 5.00E-06 273068007663 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 273068007664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007665 Acetokinase family; Region: Acetate_kinase; cl01029 273068007666 Pfam match to entry Acetate_kinase, Acetokinase family, score 393.3, E-value 2.40E-114 273068007667 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 273068007668 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 273068007669 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 273068007670 NAD binding site [chemical binding]; other site 273068007671 Phe binding site; other site 273068007672 Pfam match to entry GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, score 226.8, E-value 3.10E-64 273068007673 Pfam match to entry GLFV_dehydrog_N, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, score 178.8, E-value 4.00E-50 273068007674 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 273068007675 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 273068007676 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 273068007677 NAD binding site [chemical binding]; other site 273068007678 Phe binding site; other site 273068007679 Pfam match to entry GLFV_dehydrog, Glutamate/Leucine/Phenylalanine/Valine dehydrogenase, score 235.3, E-value 8.50E-67 273068007680 Pfam match to entry GLFV_dehydrog_N, Glu/Leu/Phe/Val dehydrogenase, dimerisation domain, score 190, E-value 2.40E-53 273068007681 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 273068007682 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 273068007683 Pfam match to entry PTA_PTB, Phosphate acetyl/butaryl transferase, score 273.2, E-value 3.30E-78 273068007684 Acetokinase family; Region: Acetate_kinase; cl01029 273068007685 Pfam match to entry Acetate_kinase, Acetokinase family, score 255.2, E-value 9.00E-73 273068007686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 273068007687 YbbR-like protein; Region: YbbR; pfam07949 273068007688 YbbR-like protein; Region: YbbR; pfam07949 273068007689 Uncharacterized conserved protein [Function unknown]; Region: COG1624 273068007690 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 273068007691 Pfam match to entry DUF147, Domain of unknown function DUF147, score 228.9, E-value 7.40E-65 273068007692 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 273068007693 Ligand Binding Site [chemical binding]; other site 273068007694 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068007695 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 273068007696 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 273068007697 Pfam match to entry Transglut_core, Transglutaminase-like superfamily, score 90.6, E-value 3.10E-23 273068007698 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 273068007699 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 273068007700 Pfam match to entry DUF58, Protein of unknown function DUF58, score 31.4, E-value 4.70E-06 273068007701 MoxR-like ATPases [General function prediction only]; Region: COG0714 273068007702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068007703 Walker A motif; other site 273068007704 ATP binding site [chemical binding]; other site 273068007705 Walker B motif; other site 273068007706 arginine finger; other site 273068007707 Pfam match to entry Mg_chelatase, Magnesium chelatase, subunit ChlI, score 42.1, E-value 5.50E-11 273068007708 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 273068007709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 273068007710 motif II; other site 273068007711 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 138.8, E-value 1.00E-37 273068007712 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 273068007713 active site 273068007714 metal binding site [ion binding]; metal-binding site 273068007715 Pfam match to entry Amidase_3, N-acetylmuramoyl-L-alanine amidase, score 124, E-value 2.80E-33 273068007716 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 273068007717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273068007718 Integrase core domain; Region: rve; cl01316 273068007719 Pfam match to entry rve, Integrase core domain, score 32.1, E-value 4.30E-08 273068007720 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068007721 putative peptidoglycan binding site; other site 273068007722 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 273068007723 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068007724 putative peptidoglycan binding site; other site 273068007725 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068007726 putative peptidoglycan binding site; other site 273068007727 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068007728 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068007729 putative peptidoglycan binding site; other site 273068007730 Pfam match to entry LysM, LysM domain, score 70.9, E-value 2.60E-17 273068007731 Pfam match to entry LysM, LysM domain, score 64.4, E-value 2.50E-15 273068007732 Pfam match to entry LysM, LysM domain, score 79.5, E-value 6.80E-20 273068007733 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 86.7, E-value 4.60E-22 273068007734 Pfam match to entry LysM, LysM domain, score 82.2, E-value 1.00E-20 273068007735 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 273068007736 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068007737 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 287.4, E-value 1.80E-82 273068007738 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 273068007739 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 273068007740 Thymidylate synthase complementing protein; Region: Thy1; cl03630 273068007741 Thymidylate synthase complementing protein; Region: Thy1; cl03630 273068007742 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 273068007743 active site 273068007744 DNA binding site [nucleotide binding] 273068007745 putative phosphate binding site [ion binding]; other site 273068007746 putative catalytic site [active] 273068007747 metal binding site A [ion binding]; metal-binding site 273068007748 AP binding site [nucleotide binding]; other site 273068007749 metal binding site B [ion binding]; metal-binding site 273068007750 Pfam match to entry AP_endonucleas1, AP endonuclease family 1, score 407.5, E-value 5.80E-123 273068007751 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045 273068007752 diiron binding motif [ion binding]; other site 273068007753 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 273068007754 non-heme iron binding site [ion binding]; other site 273068007755 tetramer interface [polypeptide binding]; other site 273068007756 Pfam match to entry Desulfoferrodox, Desulfoferrodoxin, score 160.1, E-value 3.90E-44 273068007757 DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052 273068007758 diiron binding motif [ion binding]; other site 273068007759 Cache domain; Region: Cache_1; pfam02743 273068007760 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068007761 dimerization interface [polypeptide binding]; other site 273068007762 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 273068007763 Methyl-accepting chemotaxis protein (MCP) signaling domain; Region: MCPsignal; pfam00015 273068007764 Pfam match to entry MCPsignal, Methyl-accepting chemotaxis protein (MCP) signaling domain, score 122.2, E-value 1.70E-33 273068007765 Pfam match to entry HAMP, HAMP domain, score 56, E-value 8.40E-13 273068007766 Pfam match to entry Cache, Cache domain, score 80.3, E-value 4.20E-21 273068007767 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 273068007768 substrate binding site [chemical binding]; other site 273068007769 multimerization interface [polypeptide binding]; other site 273068007770 ATP binding site [chemical binding]; other site 273068007771 Pfam match to entry HK, Hydroxyethylthiazole kinase family, score 400.8, E-value 1.30E-116 273068007772 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 273068007773 active site 273068007774 thiamine phosphate binding site [chemical binding]; other site 273068007775 pyrophosphate binding site [ion binding]; other site 273068007776 Pfam match to entry TMP-TENI, Thiamine monophosphate synthase/TENI, score 233.5, E-value 2.90E-66 273068007777 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 273068007778 putative beta-ketoacyl acyl carrier protein [ACP]reductase (BKR), subgroup 2, classical (c) SDR; Region: BKR_2_SDR_c; cd05349 273068007779 putative NAD(P) binding site [chemical binding]; other site 273068007780 active site 273068007781 Pfam match to entry adh_short, short chain dehydrogenase, score 144.9, E-value 1.50E-39 273068007782 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 273068007783 dimer interface [polypeptide binding]; other site 273068007784 substrate binding site [chemical binding]; other site 273068007785 ATP binding site [chemical binding]; other site 273068007786 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 273068007787 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 273068007788 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 273068007789 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 273068007790 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068007791 Walker A/P-loop; other site 273068007792 ATP binding site [chemical binding]; other site 273068007793 Q-loop/lid; other site 273068007794 ABC transporter signature motif; other site 273068007795 Walker B; other site 273068007796 D-loop; other site 273068007797 H-loop/switch region; other site 273068007798 Pfam match to entry ABC_tran, ABC transporter, score 139.3, E-value 6.90E-38 273068007799 Transposase domain (DUF772); Region: DUF772; cl12084 273068007800 translocation protein TolB; Provisional; Region: tolB; PRK03629 273068007801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 273068007802 putative substrate translocation pore; other site 273068007803 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068007804 putative substrate translocation pore; other site 273068007805 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 273068007806 nudix motif; other site 273068007807 Pfam match to entry mutT, MutT-like domain, score 61.4, E-value 2.00E-14 273068007808 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 273068007809 Pfam match to entry Ribosomal_S9, Ribosomal protein S9/S16, score 227.4, E-value 4.50E-70 273068007810 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 273068007811 23S rRNA interface [nucleotide binding]; other site 273068007812 L3 interface [polypeptide binding]; other site 273068007813 Pfam match to entry Ribosomal_L13, Ribosomal protein L13, score 231.7, E-value 1.00E-65 273068007814 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 273068007815 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 273068007816 dimerization interface 3.5A [polypeptide binding]; other site 273068007817 active site 273068007818 Pfam match to entry PseudoU_synth_1, tRNA pseudouridine synthase, score 279.6, E-value 4.00E-80 273068007819 Cobalt transport protein; Region: CbiQ; cl00463 273068007820 Pfam match to entry CbiQ, Cobalt transport protein, score 237.4, E-value 2.00E-67 273068007821 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 273068007822 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 273068007823 Walker A/P-loop; other site 273068007824 ATP binding site [chemical binding]; other site 273068007825 Q-loop/lid; other site 273068007826 ABC transporter signature motif; other site 273068007827 Walker B; other site 273068007828 D-loop; other site 273068007829 H-loop/switch region; other site 273068007830 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 273068007831 Pfam match to entry ABC_tran, ABC transporter, score 227.4, E-value 2.10E-64 273068007832 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 273068007833 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 273068007834 Walker A/P-loop; other site 273068007835 ATP binding site [chemical binding]; other site 273068007836 Q-loop/lid; other site 273068007837 ABC transporter signature motif; other site 273068007838 Walker B; other site 273068007839 D-loop; other site 273068007840 H-loop/switch region; other site 273068007841 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 273068007842 Pfam match to entry ABC_tran, ABC transporter, score 197.6, E-value 2.00E-55 273068007843 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 273068007844 Pfam match to entry Ribosomal_L17, Ribosomal protein L17, score 210.8, E-value 2.10E-59 273068007845 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 273068007846 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 273068007847 alphaNTD homodimer interface [polypeptide binding]; other site 273068007848 alphaNTD - beta interaction site [polypeptide binding]; other site 273068007849 alphaNTD - beta' interaction site [polypeptide binding]; other site 273068007850 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 273068007851 Pfam match to entry RNA_pol_A_bac, Bacterial RNA polymerase, alpha chain, score 536.9, E-value 1.40E-157 273068007852 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 273068007853 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 273068007854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 273068007855 RNA binding surface [nucleotide binding]; other site 273068007856 Pfam match to entry S4, S4 domain, score 101.7, E-value 1.40E-26 273068007857 Pfam match to entry Ribosomal_S4, Ribosomal protein S4/S9 N-terminal domain, score 93.9, E-value 3.20E-24 273068007858 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 273068007859 Pfam match to entry Ribosomal_S11, Ribosomal protein S11, score 259.1, E-value 9.30E-80 273068007860 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 273068007861 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 273068007862 Pfam match to entry Ribosomal_S13, Ribosomal protein S13/S18, score 213.6, E-value 3.00E-60 273068007863 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 273068007864 Pfam match to entry Ribosomal_L36, Ribosomal protein L36, score 67.9, E-value 2.00E-21 273068007865 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 273068007866 rRNA binding site [nucleotide binding]; other site 273068007867 predicted 30S ribosome binding site; other site 273068007868 Pfam match to entry S1, S1 RNA binding domain, score 51.9, E-value 9.70E-13 273068007869 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 273068007870 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 273068007871 active site 273068007872 Pfam match to entry Peptidase_M24, metallopeptidase family M24, score 308.6, E-value 7.50E-89 273068007873 adenylate kinase; Reviewed; Region: adk; PRK00279 273068007874 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 273068007875 AMP-binding site [chemical binding]; other site 273068007876 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 273068007877 Pfam match to entry adenylatekinase, Adenylate kinase, score 400.3, E-value 1.90E-116 273068007878 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 273068007879 SecY translocase; Region: SecY; pfam00344 273068007880 Pfam match to entry secY, eubacterial secY protein, score 548.1, E-value 6.20E-161 273068007881 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 273068007882 Pfam match to entry L15, Ribosomal protein L15, score 56.9, E-value 2.40E-19 273068007883 Pfam match to entry Ribosomal_L15, Ribosomal protein L15 amino terminal region, score 213, E-value 4.60E-60 273068007884 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 273068007885 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 273068007886 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 273068007887 Pfam match to entry Ribosomal_S5, Ribosomal protein S5, score 236, E-value 5.40E-67 273068007888 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 273068007889 5S rRNA interface [nucleotide binding]; other site 273068007890 L27 interface [polypeptide binding]; other site 273068007891 23S rRNA interface [nucleotide binding]; other site 273068007892 L5 interface [polypeptide binding]; other site 273068007893 Pfam match to entry Ribosomal_L18p, Ribosomal L18p/L5e family, score 212.6, E-value 5.70E-60 273068007894 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 273068007895 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 273068007896 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 273068007897 Pfam match to entry Ribosomal_L6, Ribosomal protein L6, score 260.4, E-value 1.10E-74 273068007898 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 273068007899 Pfam match to entry Ribosomal_S8, Ribosomal protein S8, score 271.9, E-value 2.10E-82 273068007900 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 273068007901 Pfam match to entry Ribosomal_S14, Ribosomal protein S14p/S29e, score 96.2, E-value 1.90E-28 273068007902 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 273068007903 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 273068007904 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 273068007905 Pfam match to entry Ribosomal_L5_C, ribosomal L5P family C-terminus, score 199.6, E-value 4.90E-56 273068007906 Pfam match to entry Ribosomal_L5, Ribosomal protein L5, score 121.3, E-value 1.90E-32 273068007907 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 273068007908 KOW motif; Region: KOW; cl00354 273068007909 Pfam match to entry Ribosomal_L24, KOW motif, score 77.5, E-value 2.80E-19 273068007910 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 273068007911 Pfam match to entry Ribosomal_L14, Ribosomal protein L14p/L23e, score 279.7, E-value 3.60E-80 273068007912 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 273068007913 Pfam match to entry Ribosomal_S17, Ribosomal protein S17, score 144.4, E-value 9.60E-42 273068007914 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 273068007915 23S rRNA interface [nucleotide binding]; other site 273068007916 putative translocon interaction site; other site 273068007917 signal recognition particle (SRP54) interaction site; other site 273068007918 L23 interface [polypeptide binding]; other site 273068007919 trigger factor interaction site; other site 273068007920 Pfam match to entry Ribosomal_L29, Ribosomal L29 protein, score 115.8, E-value 8.30E-31 273068007921 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 273068007922 23S rRNA interface [nucleotide binding]; other site 273068007923 5S rRNA interface [nucleotide binding]; other site 273068007924 putative antibiotic binding site [chemical binding]; other site 273068007925 L25 interface [polypeptide binding]; other site 273068007926 L27 interface [polypeptide binding]; other site 273068007927 Pfam match to entry Ribosomal_L16, Ribosomal protein L16, score 317.7, E-value 5.30E-92 273068007928 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 273068007929 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 273068007930 G-X-X-G motif; other site 273068007931 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 273068007932 Pfam match to entry Ribosomal_S3_C, Ribosomal protein S3, C-terminal domain., score 164.7, E-value 1.20E-50 273068007933 Pfam match to entry Ribosomal_S3_N, Ribosomal protein S3, N-terminal domain., score 86.5, E-value 1.10E-26 273068007934 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 273068007935 putative translocon binding site; other site 273068007936 protein-rRNA interface [nucleotide binding]; other site 273068007937 Pfam match to entry Ribosomal_L22, Ribosomal protein L22p/L17e, score 201.6, E-value 1.30E-56 273068007938 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 273068007939 Pfam match to entry Ribosomal_S19, Ribosomal protein S19, score 186, E-value 2.60E-53 273068007940 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 273068007941 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 273068007942 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 273068007943 Pfam match to entry Ribosomal_L2, Ribosomal Proteins L2, score 475.2, E-value 5.10E-139 273068007944 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 273068007945 Pfam match to entry Ribosomal_L23, Ribosomal protein L23, score 148, E-value 1.30E-42 273068007946 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 273068007947 Pfam match to entry Ribosomal_L4, Ribosomal protein L4/L1 family, score 274.9, E-value 1.10E-78 273068007948 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 273068007949 Pfam match to entry Ribosomal_L3, Ribosomal protein L3, score 357.7, E-value 1.20E-103 273068007950 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 273068007951 Pfam match to entry Ribosomal_S10, Ribosomal protein S10p/S20e, score 220.7, E-value 2.20E-62 273068007952 elongation factor Tu; Reviewed; Region: PRK00049 273068007953 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 273068007954 G1 box; other site 273068007955 GEF interaction site [polypeptide binding]; other site 273068007956 GTP/Mg2+ binding site [chemical binding]; other site 273068007957 Switch I region; other site 273068007958 G2 box; other site 273068007959 G3 box; other site 273068007960 Switch II region; other site 273068007961 G4 box; other site 273068007962 G5 box; other site 273068007963 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 273068007964 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 273068007965 Antibiotic Binding Site [chemical binding]; other site 273068007966 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 568.6, E-value 4.00E-167 273068007967 elongation factor G; Reviewed; Region: PRK00007 273068007968 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 273068007969 G1 box; other site 273068007970 putative GEF interaction site [polypeptide binding]; other site 273068007971 GTP/Mg2+ binding site [chemical binding]; other site 273068007972 Switch I region; other site 273068007973 G2 box; other site 273068007974 G3 box; other site 273068007975 Switch II region; other site 273068007976 G4 box; other site 273068007977 G5 box; other site 273068007978 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 273068007979 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 273068007980 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 273068007981 Pfam match to entry EFG_C, Elongation factor G C-terminus, score 377.6, E-value 1.30E-109 273068007982 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 634, E-value 8.40E-187 273068007983 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 273068007984 Pfam match to entry Ribosomal_S7, Ribosomal protein S7p/S5e, score 334.1, E-value 1.60E-96 273068007985 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 273068007986 S17 interaction site [polypeptide binding]; other site 273068007987 S8 interaction site; other site 273068007988 16S rRNA interaction site [nucleotide binding]; other site 273068007989 streptomycin interaction site [chemical binding]; other site 273068007990 23S rRNA interaction site [nucleotide binding]; other site 273068007991 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 273068007992 Pfam match to entry Ribosomal_S12, Ribosomal protein S12, score 273.9, E-value 2.10E-78 273068007993 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 273068007994 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 273068007995 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 273068007996 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 273068007997 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 273068007998 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 273068007999 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 273068008000 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 273068008001 G-loop; other site 273068008002 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 273068008003 DNA binding site [nucleotide binding] 273068008004 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 273068008005 Pfam match to entry RNA_pol_A2, 'RNA polymerase A/beta'/A'' subunit', score -30.1, E-value 1.00E-07 273068008006 Pfam match to entry RNA_pol_A, RNA polymerase alpha subunit, score 1008.2, E-value 0 273068008007 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 273068008008 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 273068008009 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 273068008010 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 273068008011 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 273068008012 RPB1 interaction site [polypeptide binding]; other site 273068008013 RPB10 interaction site [polypeptide binding]; other site 273068008014 RPB11 interaction site [polypeptide binding]; other site 273068008015 RPB3 interaction site [polypeptide binding]; other site 273068008016 RPB12 interaction site [polypeptide binding]; other site 273068008017 Pfam match to entry RNA_pol_B, RNA polymerase beta subunit, score 1823.4, E-value 0 273068008018 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 273068008019 core dimer interface [polypeptide binding]; other site 273068008020 peripheral dimer interface [polypeptide binding]; other site 273068008021 L10 interface [polypeptide binding]; other site 273068008022 L11 interface [polypeptide binding]; other site 273068008023 putative EF-Tu interaction site [polypeptide binding]; other site 273068008024 putative EF-G interaction site [polypeptide binding]; other site 273068008025 Pfam match to entry Ribosomal_L12, Ribosomal protein L7/L12 C-terminal domain, score 144.8, E-value 1.50E-39 273068008026 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 273068008027 23S rRNA interface [nucleotide binding]; other site 273068008028 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 273068008029 Pfam match to entry Ribosomal_L10, Ribosomal protein L10, score 87, E-value 3.70E-22 273068008030 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 273068008031 mRNA/rRNA interface [nucleotide binding]; other site 273068008032 Pfam match to entry Ribosomal_L1, Ribosomal protein L1p/L10e family, score 425.9, E-value 3.70E-124 273068008033 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 273068008034 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 273068008035 23S rRNA interface [nucleotide binding]; other site 273068008036 L7/L12 interface [polypeptide binding]; other site 273068008037 putative thiostrepton binding site; other site 273068008038 L25 interface [polypeptide binding]; other site 273068008039 Pfam match to entry Ribosomal_L11, Ribosomal protein L11, score 280.9, E-value 1.60E-80 273068008040 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 273068008041 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 273068008042 putative homodimer interface [polypeptide binding]; other site 273068008043 KOW motif; Region: KOW; cl00354 273068008044 Pfam match to entry NusG, Transcription termination factor nusG, score 90.7, E-value 2.80E-23 273068008045 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 273068008046 Pfam match to entry SecE, SecE/Sec61-gamma subunits of protein translocation complex, score 68.9, E-value 1.10E-16 273068008047 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 273068008048 Pfam match to entry Ribosomal_L33, Ribosomal protein L33, score 88.4, E-value 1.40E-22 273068008049 elongation factor Tu; Reviewed; Region: PRK00049 273068008050 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 273068008051 G1 box; other site 273068008052 GEF interaction site [polypeptide binding]; other site 273068008053 GTP/Mg2+ binding site [chemical binding]; other site 273068008054 Switch I region; other site 273068008055 G2 box; other site 273068008056 G3 box; other site 273068008057 Switch II region; other site 273068008058 G4 box; other site 273068008059 G5 box; other site 273068008060 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 273068008061 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 273068008062 Antibiotic Binding Site [chemical binding]; other site 273068008063 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 570.9, E-value 8.30E-168 273068008064 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 273068008065 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068008066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15761 273068008067 Pfam match to entry sigma70, Sigma-70 factor, score 118.6, E-value 1.20E-31 273068008068 YacP-like NYN domain; Region: NYN_YacP; cl01491 273068008069 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 273068008070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 273068008071 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 273068008072 Pfam match to entry SpoU_methylase, SpoU rRNA Methylase family, score 205.8, E-value 6.60E-58 273068008073 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258 273068008074 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 273068008075 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 273068008076 active site 273068008077 HIGH motif; other site 273068008078 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 273068008079 KMSKS motif; other site 273068008080 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 273068008081 tRNA binding surface [nucleotide binding]; other site 273068008082 anticodon binding site; other site 273068008083 Pfam match to entry tRNA-synt_1e, tRNA synthetases class I (C), score 831.2, E-value 3.60E-246 273068008084 serine O-acetyltransferase; Region: cysE; TIGR01172 273068008085 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 273068008086 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 273068008087 trimer interface [polypeptide binding]; other site 273068008088 active site 273068008089 substrate binding site [chemical binding]; other site 273068008090 CoA binding site [chemical binding]; other site 273068008091 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 273068008092 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273068008093 HIGH motif; other site 273068008094 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 273068008095 active site 273068008096 KMSKS motif; other site 273068008097 Pfam match to entry tRNA-synt_1c, tRNA synthetases class I (E and Q), score 657.1, E-value 9.30E-194 273068008098 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 273068008099 prolyl-tRNA synthetase; Provisional; Region: PRK09194 273068008100 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 273068008101 dimer interface [polypeptide binding]; other site 273068008102 motif 1; other site 273068008103 active site 273068008104 motif 2; other site 273068008105 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 273068008106 putative deacylase active site [active] 273068008107 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 273068008108 active site 273068008109 motif 3; other site 273068008110 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 273068008111 anticodon binding site; other site 273068008112 Pfam match to entry tRNA-synt_2b, tRNA synthetase class II (G, H, P, S and T), score 73.1, E-value 5.90E-18 273068008113 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 273068008114 homotrimer interaction site [polypeptide binding]; other site 273068008115 zinc binding site [ion binding]; other site 273068008116 CDP-binding sites; other site 273068008117 Pfam match to entry YgbB, YgbB family, score 297.8, E-value 1.30E-85 273068008118 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068008119 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 273068008120 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 273068008121 substrate binding site; other site 273068008122 dimer interface; other site 273068008123 Pfam match to entry UPF0007, Uncharacterized protein family UPF0007, score 269.2, E-value 5.60E-77 273068008124 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 273068008125 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 273068008126 putative active site [active] 273068008127 DNA repair protein RadA; Provisional; Region: PRK11823 273068008128 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 273068008129 Walker A motif/ATP binding site; other site 273068008130 ATP binding site [chemical binding]; other site 273068008131 Walker B motif; other site 273068008132 Subunit ChlI of Mg-chelatase; Region: ChlI; cl12214 273068008133 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 273068008134 Pfam match to entry Nramp, Natural resistance-associated macrophage protein, score 425.7, E-value 4.10E-124 273068008135 Clp protease ATP binding subunit; Region: clpC; CHL00095 273068008136 Clp amino terminal domain; Region: Clp_N; pfam02861 273068008137 Clp amino terminal domain; Region: Clp_N; pfam02861 273068008138 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068008139 Walker A motif; other site 273068008140 ATP binding site [chemical binding]; other site 273068008141 Walker B motif; other site 273068008142 arginine finger; other site 273068008143 UvrB/uvrC motif; Region: UVR; pfam02151 273068008144 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068008145 Walker A motif; other site 273068008146 ATP binding site [chemical binding]; other site 273068008147 Walker B motif; other site 273068008148 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 273068008149 Pfam match to entry UVR, UvrB/uvrC motif, score 47.1, E-value 3.80E-10 273068008150 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 61.5, E-value 1.80E-14 273068008151 Pfam match to entry Clp_N, Clp amino terminal domain, score 77.2, E-value 3.30E-19 273068008152 Pfam match to entry Clp_N, Clp amino terminal domain, score 85.6, E-value 1.00E-21 273068008153 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 273068008154 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 273068008155 ADP binding site [chemical binding]; other site 273068008156 phosphagen binding site; other site 273068008157 substrate specificity loop; other site 273068008158 Pfam match to entry ATP-gua_Ptrans, ATP:guanido phosphotransferase, C-terminal catalytic domain, score 64.2, E-value 1.00E-17 273068008159 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 273068008160 Pfam match to entry UVR, UvrB/uvrC motif, score 37.2, E-value 3.80E-07 273068008161 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 273068008162 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 273068008163 Malic enzyme, N-terminal domain; Region: malic; pfam00390 273068008164 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 273068008165 putative NAD(P) binding site [chemical binding]; other site 273068008166 Pfam match to entry malic, Malic enzyme, score 52.4, E-value 3.80E-12 273068008167 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 273068008168 elongation factor G; Reviewed; Region: PRK12740 273068008169 G1 box; other site 273068008170 putative GEF interaction site [polypeptide binding]; other site 273068008171 GTP/Mg2+ binding site [chemical binding]; other site 273068008172 Switch I region; other site 273068008173 G2 box; other site 273068008174 G3 box; other site 273068008175 Switch II region; other site 273068008176 G4 box; other site 273068008177 G5 box; other site 273068008178 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 273068008179 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 273068008180 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 273068008181 Pfam match to entry EFG_C, Elongation factor G C-terminus, score 323.8, E-value 2.00E-93 273068008182 Pfam match to entry GTP_EFTU, Elongation factor Tu family, score 370.6, E-value 1.60E-107 273068008183 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 273068008184 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 273068008185 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 273068008186 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 273068008187 Pfam match to entry PEP-utilizers_C, PEP-utilizing enzyme, TIM barrel domain, score 634.6, E-value 5.50E-187 273068008188 Pfam match to entry PEP-utilizers, PEP-utilizing enzyme, mobile domain, score 129.9, E-value 4.60E-35 273068008189 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 273068008190 GAF domain; Region: GAF; cl00853 273068008191 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 273068008192 metal binding site [ion binding]; metal-binding site 273068008193 active site 273068008194 I-site; other site 273068008195 Pfam match to entry GGDEF, GGDEF domain, score 212, E-value 9.30E-60 273068008196 Pfam match to entry GAF, GAF domain, score 59.7, E-value 6.40E-14 273068008197 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 273068008198 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 273068008199 active site 273068008200 dimer interface [polypeptide binding]; other site 273068008201 effector binding site; other site 273068008202 TSCPD domain; Region: TSCPD; cl14834 273068008203 Pfam match to entry ribonuc_red_lgC, Ribonucleotide reductase, barrel domain, score 126.6, E-value 4.60E-34 273068008204 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273068008205 catalytic residues [active] 273068008206 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 273068008207 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273068008208 inhibitor-cofactor binding pocket; inhibition site 273068008209 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068008210 catalytic residue [active] 273068008211 Pfam match to entry aminotran_3, Aminotransferase class-III, score 536.6, E-value 8.80E-161 273068008212 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 273068008213 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 273068008214 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068008215 Response regulator receiver domain; Region: Response_reg; pfam00072 273068008216 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068008217 active site 273068008218 phosphorylation site [posttranslational modification] 273068008219 intermolecular recognition site; other site 273068008220 dimerization interface [polypeptide binding]; other site 273068008221 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273068008222 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 273068008223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 273068008224 Pfam match to entry HTH_AraC, Bacterial regulatory helix-turn-helix proteins, araC family, score 116, E-value 7.20E-31 273068008225 Pfam match to entry response_reg, Response regulator receiver domain, score 83.9, E-value 3.20E-21 273068008226 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 273068008227 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068008228 dimerization interface [polypeptide binding]; other site 273068008229 Histidine kinase; Region: His_kinase; pfam06580 273068008230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068008231 ATP binding site [chemical binding]; other site 273068008232 Mg2+ binding site [ion binding]; other site 273068008233 G-X-G motif; other site 273068008234 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 42.7, E-value 2.00E-10 273068008235 Pfam match to entry HAMP, HAMP domain, score 45.3, E-value 1.40E-09 273068008236 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273068008237 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068008238 Pfam match to entry SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 164.5, E-value 1.80E-45 273068008239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068008240 putative PBP binding loops; other site 273068008241 dimer interface [polypeptide binding]; other site 273068008242 ABC-ATPase subunit interface; other site 273068008243 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 59.6, E-value 6.90E-14 273068008244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273068008245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068008246 dimer interface [polypeptide binding]; other site 273068008247 conserved gate region; other site 273068008248 putative PBP binding loops; other site 273068008249 ABC-ATPase subunit interface; other site 273068008250 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 49.6, E-value 6.80E-11 273068008251 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 273068008252 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 273068008253 Pfam match to entry Glyco_hydro_30, O-Glycosyl hydrolase family 30, score 327.2, E-value 1.90E-94 273068008254 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 273068008255 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 273068008256 Pfam match to entry Glyco_hydro_30, O-Glycosyl hydrolase family 30, score 91.9, E-value 1.20E-23 273068008257 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068008258 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068008259 Active site serine [active] 273068008260 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068008261 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068008262 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068008263 Walker A/P-loop; other site 273068008264 ATP binding site [chemical binding]; other site 273068008265 Q-loop/lid; other site 273068008266 ABC transporter signature motif; other site 273068008267 Walker B; other site 273068008268 D-loop; other site 273068008269 H-loop/switch region; other site 273068008270 Pfam match to entry ABC_tran, ABC transporter, score 183, E-value 5.00E-51 273068008271 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 77.1, E-value 3.70E-19 273068008272 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068008273 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068008274 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068008275 Walker A/P-loop; other site 273068008276 ATP binding site [chemical binding]; other site 273068008277 Q-loop/lid; other site 273068008278 ABC transporter signature motif; other site 273068008279 Walker B; other site 273068008280 D-loop; other site 273068008281 H-loop/switch region; other site 273068008282 Pfam match to entry ABC_tran, ABC transporter, score 173.7, E-value 3.00E-48 273068008283 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 72.8, E-value 7.20E-18 273068008284 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068008285 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 273068008286 active site triad [active] 273068008287 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068008288 Interphotoreceptor retinoid-binding protein; serine protease family S41; Region: Peptidase_S41_IRBP; cd07563 273068008289 active site triad [active] 273068008290 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 273068008291 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068008292 FeS/SAM binding site; other site 273068008293 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068008294 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 273068008295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273068008296 Integrase core domain; Region: rve; cl01316 273068008297 Pfam match to entry rve, Integrase core domain, score 30.7, E-value 1.00E-07 273068008298 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068008299 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 273068008300 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cl02713 273068008301 Sugar fermentation stimulation protein; Region: SfsA; cl00647 273068008302 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 273068008303 active site 273068008304 Pfam match to entry PTPS, 6-pyruvoyl tetrahydropterin synthase, score 29.6, E-value 3.90E-08 273068008305 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 273068008306 catalytic center binding site [active] 273068008307 ATP binding site [chemical binding]; other site 273068008308 Pfam match to entry HPPK, 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK), score 217.6, E-value 2.90E-62 273068008309 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 273068008310 dihydropteroate synthase; Region: DHPS; TIGR01496 273068008311 substrate binding pocket [chemical binding]; other site 273068008312 dimer interface [polypeptide binding]; other site 273068008313 inhibitor binding site; inhibition site 273068008314 Pfam match to entry DHPS, Dihydropteroate synthase, score 494.1, E-value 1.10E-144 273068008315 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 273068008316 homodecamer interface [polypeptide binding]; other site 273068008317 GTP cyclohydrolase I; Provisional; Region: PLN03044 273068008318 active site 273068008319 putative catalytic site residues [active] 273068008320 zinc binding site [ion binding]; other site 273068008321 GTP-CH-I/GFRP interaction surface; other site 273068008322 Pfam match to entry GTP_cyclohydroI, GTP cyclohydrolase I, score 361.7, E-value 5.30E-111 273068008323 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 273068008324 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 273068008325 dimer interface [polypeptide binding]; other site 273068008326 putative anticodon binding site; other site 273068008327 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 273068008328 motif 1; other site 273068008329 active site 273068008330 motif 2; other site 273068008331 motif 3; other site 273068008332 Pfam match to entry tRNA-synt_2, tRNA synthetases class II (D, K and N), score 617.3, E-value 8.90E-182 273068008333 Pfam match to entry tRNA_anti, OB-fold nucleic acid binding domain, score 72.1, E-value 1.20E-17 273068008334 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 273068008335 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 273068008336 Pfam match to entry GreA_GreB, Prokaryotic transcription elongation factor, GreA/GreB, score 196.8, E-value 3.40E-55 273068008337 Predicted dehydrogenase [General function prediction only]; Region: COG5322 273068008338 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 273068008339 NADP binding site [chemical binding]; other site 273068008340 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 273068008341 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 273068008342 Amino acid permease; Region: AA_permease; cl00524 273068008343 Type III pantothenate kinase; Region: Pan_kinase; cl09130 273068008344 Predicted membrane protein [Function unknown]; Region: COG4684 273068008345 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 273068008346 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 273068008347 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 273068008348 carboxyltransferase (CT) interaction site; other site 273068008349 biotinylation site [posttranslational modification]; other site 273068008350 Pfam match to entry biotin_lipoyl, Biotin-requiring enzyme, score 97, E-value 3.90E-25 273068008351 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 273068008352 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 273068008353 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl15772 273068008354 Pfam match to entry Carboxyl_trans, Carboxyl transferase domain, score 1053, E-value 0 273068008355 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 273068008356 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 273068008357 dimer interface [polypeptide binding]; other site 273068008358 substrate binding site [chemical binding]; other site 273068008359 metal binding site [ion binding]; metal-binding site 273068008360 Pfam match to entry Glyoxalase, Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily, score 84, E-value 5.50E-23 273068008361 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068008362 ArgK protein; Region: ArgK; pfam03308 273068008363 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 273068008364 Walker A; other site 273068008365 G1 box; other site 273068008366 GTP/Mg2+ binding site [chemical binding]; other site 273068008367 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 273068008368 B12 binding site [chemical binding]; other site 273068008369 cobalt ligand [ion binding]; other site 273068008370 Pfam match to entry B12-binding, B12 binding domain, score 167.6, E-value 2.10E-46 273068008371 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 273068008372 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 273068008373 Pfam match to entry MM_CoA_mutase, Methylmalonyl-CoA mutase, score 938.4, E-value 1.90E-278 273068008374 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 273068008375 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 273068008376 Potassium binding sites [ion binding]; other site 273068008377 Cesium cation binding sites [ion binding]; other site 273068008378 Pfam match to entry FTHFS, Formate--tetrahydrofolate ligase, score 1178.4, E-value 0 273068008379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068008380 PAS domain S-box; Region: sensory_box; TIGR00229 273068008381 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068008382 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 273068008383 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068008384 dimer interface [polypeptide binding]; other site 273068008385 phosphorylation site [posttranslational modification] 273068008386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068008387 ATP binding site [chemical binding]; other site 273068008388 Mg2+ binding site [ion binding]; other site 273068008389 G-X-G motif; other site 273068008390 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 104.3, E-value 1.80E-27 273068008391 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 32.7, E-value 8.70E-06 273068008392 FtsH Extracellular; Region: FtsH_ext; pfam06480 273068008393 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 273068008394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068008395 Walker A motif; other site 273068008396 ATP binding site [chemical binding]; other site 273068008397 Walker B motif; other site 273068008398 arginine finger; other site 273068008399 Peptidase family M41; Region: Peptidase_M41; pfam01434 273068008400 Pfam match to entry Peptidase_M41, Peptidase family M41, score 400.7, E-value 1.40E-116 273068008401 Pfam match to entry AAA, ATPase family associated with various cellular activities (AAA), score 341.3, E-value 1.10E-98 273068008402 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068008403 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 118.7, E-value 1.10E-31 273068008404 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 273068008405 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 273068008406 Ligand Binding Site [chemical binding]; other site 273068008407 B3/4 domain; Region: B3_4; cl11458 273068008408 stage II sporulation protein E; Region: spore_II_E; TIGR02865 273068008409 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 273068008410 tellurite resistance protein TehB; Provisional; Region: PRK12335 273068008411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068008412 S-adenosylmethionine binding site [chemical binding]; other site 273068008413 EamA-like transporter family; Region: EamA; cl01037 273068008414 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 273068008415 EamA-like transporter family; Region: EamA; cl01037 273068008416 Pfam match to entry DUF6, Integral membrane protein DUF6, score 93.2, E-value 5.20E-24 273068008417 Pfam match to entry DUF6, Integral membrane protein DUF6, score 94.8, E-value 1.70E-24 273068008418 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 273068008419 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 273068008420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 273068008421 DNA binding residues [nucleotide binding] 273068008422 Anti-sigma-K factor rskA; Region: RskA; cl15366 273068008423 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 273068008424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 273068008425 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 273068008426 Walker A/P-loop; other site 273068008427 ATP binding site [chemical binding]; other site 273068008428 Q-loop/lid; other site 273068008429 ABC transporter signature motif; other site 273068008430 Walker B; other site 273068008431 D-loop; other site 273068008432 H-loop/switch region; other site 273068008433 Pfam match to entry ABC_tran, ABC transporter, score 166.5, E-value 4.60E-46 273068008434 ABC-2 type transporter; Region: ABC2_membrane; cl11417 273068008435 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 273068008436 Threonine dehydrogenase; Region: TDH; cd05281 273068008437 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 273068008438 structural Zn binding site [ion binding]; other site 273068008439 catalytic Zn binding site [ion binding]; other site 273068008440 tetramer interface [polypeptide binding]; other site 273068008441 NADP binding site [chemical binding]; other site 273068008442 Pfam match to entry adh_zinc, Zinc-binding dehydrogenases, score 343.2, E-value 2.80E-99 273068008443 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 273068008444 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273068008445 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273068008446 catalytic residue [active] 273068008447 Pfam match to entry aminotran_2, Aminotransferase class-II, score 229.9, E-value 3.70E-65 273068008448 uracil transporter; Provisional; Region: PRK10720 273068008449 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 273068008450 Pfam match to entry xan_ur_permease, Xanthine/uracil permeases family, score 392.5, E-value 4.20E-114 273068008451 Transposase [DNA replication, recombination, and repair]; Region: COG5421 273068008452 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 273068008453 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 273068008454 S-layer homology domain; Region: SLH; pfam00395 273068008455 S-layer homology domain; Region: SLH; pfam00395 273068008456 S-layer homology domain; Region: SLH; pfam00395 273068008457 Pfam match to entry SLH, S-layer homology domain, score 53.7, E-value 4.00E-12 273068008458 Pfam match to entry SLH, S-layer homology domain, score 56, E-value 8.00E-13 273068008459 Pfam match to entry SLH, S-layer homology domain, score 68.8, E-value 1.20E-16 273068008460 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 273068008461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068008462 dimer interface [polypeptide binding]; other site 273068008463 conserved gate region; other site 273068008464 putative PBP binding loops; other site 273068008465 ABC-ATPase subunit interface; other site 273068008466 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 69.4, E-value 7.60E-17 273068008467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068008468 dimer interface [polypeptide binding]; other site 273068008469 conserved gate region; other site 273068008470 putative PBP binding loops; other site 273068008471 ABC-ATPase subunit interface; other site 273068008472 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 65.2, E-value 1.40E-15 273068008473 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 273068008474 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 273068008475 Pfam match to entry SBP_bacterial_1, Bacterial extracellular solute-binding protein, score 209.4, E-value 5.50E-59 273068008476 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273068008477 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 273068008478 Pfam match to entry ROK, ROK family, score 160.2, E-value 1.50E-46 273068008479 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 273068008480 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 273068008481 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 273068008482 putative active site [active] 273068008483 Pfam match to entry SIS, SIS domain, score 106.9, E-value 3.90E-28 273068008484 Pfam match to entry HTH_6, Helix-turn-helix domain, rpiR family, score 130.9, E-value 2.30E-35 273068008485 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 273068008486 putative active site cavity [active] 273068008487 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 273068008488 active site 273068008489 nucleotide-binding site [chemical binding]; other site 273068008490 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 273068008491 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 273068008492 active site 273068008493 metal binding site [ion binding]; metal-binding site 273068008494 Pfam match to entry Amidase_3, N-acetylmuramoyl-L-alanine amidase, score 147.8, E-value 1.90E-40 273068008495 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 273068008496 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 273068008497 Pfam match to entry DUF105, Domain of unknown function DUF105, score 172.7, E-value 6.10E-48 273068008498 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 273068008499 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068008500 Pfam match to entry GFO_IDH_MocA, Oxidoreductase family, NAD-binding Rossmann fold, score 117.8, E-value 2.00E-31 273068008501 SEC-C motif; Region: SEC-C; pfam02810 273068008502 Pfam match to entry SEC-C, SEC-C motif, score 38.6, E-value 1.40E-07 273068008503 B3/4 domain; Region: B3_4; cl11458 273068008504 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068008505 Pfam match to entry lactamase_B, Metallo-beta-lactamase superfamily, score 47.6, E-value 2.70E-10 273068008506 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 273068008507 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 273068008508 hypothetical protein; Validated; Region: PRK07682 273068008509 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 273068008510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068008511 homodimer interface [polypeptide binding]; other site 273068008512 catalytic residue [active] 273068008513 Pfam match to entry aminotran_1, Aminotransferase class-I, score 291, E-value 1.40E-83 273068008514 Pfam match to entry aminotran_2, Aminotransferase class-II, score -14.9, E-value 5.20E-06 273068008515 Helix-turn-helix domains; Region: HTH; cl00088 273068008516 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 273068008517 Pfam match to entry Ppx-GppA, Ppx/GppA phosphatase family, score 157.6, E-value 2.10E-43 273068008518 hypothetical protein; Provisional; Region: PRK05807 273068008519 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 273068008520 RNA binding site [nucleotide binding]; other site 273068008521 Pfam match to entry S1, S1 RNA binding domain, score 81.3, E-value 7.40E-21 273068008522 Septum formation initiator; Region: DivIC; cl11433 273068008523 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 273068008524 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 273068008525 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 273068008526 DRTGG domain; Region: DRTGG; cl12147 273068008527 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 273068008528 DHH family; Region: DHH; pfam01368 273068008529 DHHA2 domain; Region: DHHA2; pfam02833 273068008530 Pfam match to entry CBS, CBS domain, score 45.8, E-value 9.90E-10 273068008531 Pfam match to entry CBS, CBS domain, score 36.4, E-value 6.30E-07 273068008532 Pfam match to entry DHHA2, DHHA2 domain, score 102.9, E-value 6.10E-27 273068008533 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 273068008534 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068008535 YabP family; Region: YabP; cl06766 273068008536 Stage II sporulation protein; Region: SpoIID; pfam08486 273068008537 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 273068008538 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 273068008539 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 273068008540 IHF dimer interface [polypeptide binding]; other site 273068008541 IHF - DNA interface [nucleotide binding]; other site 273068008542 Pfam match to entry Bac_DNA_binding, Bacterial DNA-binding protein, score 184.7, E-value 8.40E-52 273068008543 Precorrin-3B methylase [Coenzyme metabolism]; Region: CobJ; cl00304 273068008544 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 273068008545 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 273068008546 Pfam match to entry TP_methylase, Tetrapyrrole (Corrin/Porphyrin) Methylases., score 63.4, E-value 4.70E-15 273068008547 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068008548 non-specific DNA binding site [nucleotide binding]; other site 273068008549 salt bridge; other site 273068008550 sequence-specific DNA binding site [nucleotide binding]; other site 273068008551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 273068008552 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068008553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 273068008554 binding surface 273068008555 TPR motif; other site 273068008556 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068008557 Tetratricopeptide repeat; Region: TPR_12; pfam13424 273068008558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068008559 H+ Antiporter protein; Region: 2A0121; TIGR00900 273068008560 putative substrate translocation pore; other site 273068008561 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 273068008562 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 273068008563 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 273068008564 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 273068008565 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 273068008566 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273068008567 metal-binding site [ion binding] 273068008568 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 273068008569 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273068008570 metal-binding site [ion binding] 273068008571 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273068008572 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068008573 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 126.7, E-value 4.30E-34 273068008574 Pfam match to entry E1-E2_ATPase, E1-E2 ATPase, score 388.2, E-value 8.50E-117 273068008575 Pfam match to entry HMA, Heavy-metal-associated domain, score 99.6, E-value 6.60E-27 273068008576 Pfam match to entry HMA, Heavy-metal-associated domain, score 93.5, E-value 3.70E-25 273068008577 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 273068008578 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 273068008579 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 273068008580 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 273068008581 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273068008582 catalytic residue [active] 273068008583 Pfam match to entry aminotran_5, Aminotransferase class-V, score 445.5, E-value 4.70E-130 273068008584 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 273068008585 metal-binding site [ion binding] 273068008586 Pfam match to entry HMA, Heavy-metal-associated domain, score 83.9, E-value 1.90E-22 273068008587 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 273068008588 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273068008589 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068008590 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 98.8, E-value 1.10E-25 273068008591 Pfam match to entry E1-E2_ATPase, E1-E2 ATPase, score 270.8, E-value 3.50E-81 273068008592 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273068008593 dimerization interface [polypeptide binding]; other site 273068008594 putative DNA binding site [nucleotide binding]; other site 273068008595 putative Zn2+ binding site [ion binding]; other site 273068008596 Pfam match to entry HTH_5, Bacterial regulatory protein, arsR family, score 123.3, E-value 4.50E-33 273068008597 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 273068008598 Ligand Binding Site [chemical binding]; other site 273068008599 TIGR00269 family protein; Region: TIGR00269 273068008600 Pfam match to entry UPF0021, Uncharacterized protein family UPF0021, score 248.5, E-value 9.10E-71 273068008601 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 273068008602 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 273068008603 putative ATP binding site [chemical binding]; other site 273068008604 putative substrate interface [chemical binding]; other site 273068008605 Pfam match to entry ThiF_family, ThiF family, score 132.2, E-value 9.30E-36 273068008606 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 273068008607 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068008608 dimerization interface [polypeptide binding]; other site 273068008609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 273068008610 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068008611 dimer interface [polypeptide binding]; other site 273068008612 phosphorylation site [posttranslational modification] 273068008613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068008614 ATP binding site [chemical binding]; other site 273068008615 Mg2+ binding site [ion binding]; other site 273068008616 G-X-G motif; other site 273068008617 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 154.8, E-value 1.50E-42 273068008618 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 57, E-value 4.10E-13 273068008619 Pfam match to entry HAMP, HAMP domain, score 46.2, E-value 7.40E-10 273068008620 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273068008621 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068008622 active site 273068008623 phosphorylation site [posttranslational modification] 273068008624 intermolecular recognition site; other site 273068008625 dimerization interface [polypeptide binding]; other site 273068008626 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273068008627 DNA binding site [nucleotide binding] 273068008628 Pfam match to entry trans_reg_C, Transcriptional regulatory protein, C terminal, score 123.7, E-value 1.00E-35 273068008629 Pfam match to entry response_reg, Response regulator receiver domain, score 149.8, E-value 4.60E-41 273068008630 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 273068008631 Short C-terminal domain; Region: SHOCT; cl01373 273068008632 Helix-turn-helix domains; Region: HTH; cl00088 273068008633 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 273068008634 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 273068008635 dimer interface [polypeptide binding]; other site 273068008636 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068008637 catalytic residue [active] 273068008638 Pfam match to entry PALP, Pyridoxal-phosphate dependent enzyme, score 460.5, E-value 1.40E-134 273068008639 Uncharacterized conserved protein [Function unknown]; Region: COG2461 273068008640 Family of unknown function (DUF438); Region: DUF438; pfam04282 273068008641 FMN-binding domain; Region: FMN_bind; cl01081 273068008642 UbiA prenyltransferase family; Region: UbiA; cl00337 273068008643 Pfam match to entry UbiA, UbiA prenyltransferase family, score 41.2, E-value 2.30E-08 273068008644 ApbE family; Region: ApbE; cl00643 273068008645 Pfam match to entry ApbE, ApbE family, score 257.6, E-value 1.70E-73 273068008646 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 273068008647 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 273068008648 substrate binding pocket [chemical binding]; other site 273068008649 chain length determination region; other site 273068008650 substrate-Mg2+ binding site; other site 273068008651 catalytic residues [active] 273068008652 aspartate-rich region 1; other site 273068008653 active site lid residues [active] 273068008654 aspartate-rich region 2; other site 273068008655 Pfam match to entry polyprenyl_synt, Polyprenyl synthetase, score 198.4, E-value 1.10E-55 273068008656 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 273068008657 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 273068008658 trimer interface [polypeptide binding]; other site 273068008659 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 273068008660 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068008661 DoxX; Region: DoxX; cl00976 273068008662 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 129.9, E-value 4.70E-35 273068008663 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273068008664 catalytic core [active] 273068008665 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 273068008666 Pfam match to entry PGAM, Phosphoglycerate mutase family, score 453.4, E-value 2.00E-132 273068008667 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 273068008668 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 273068008669 active site 273068008670 Zn binding site [ion binding]; other site 273068008671 Pfam match to entry Peptidase_M3, Peptidase family M3, score -39.4, E-value 3.30E-07 273068008672 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 273068008673 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 273068008674 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273068008675 Integrase core domain; Region: rve; cl01316 273068008676 Pfam match to entry rve, Integrase core domain, score 30.7, E-value 1.00E-07 273068008677 argininosuccinate lyase; Provisional; Region: PRK00855 273068008678 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 273068008679 active sites [active] 273068008680 tetramer interface [polypeptide binding]; other site 273068008681 Pfam match to entry lyase_1, Lyase, score 451.8, E-value 6.00E-132 273068008682 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 273068008683 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 273068008684 ANP binding site [chemical binding]; other site 273068008685 Substrate Binding Site II [chemical binding]; other site 273068008686 Substrate Binding Site I [chemical binding]; other site 273068008687 Pfam match to entry Arginosuc_synth, Arginosuccinate synthase, score 780.3, E-value 4.30E-245 273068008688 acetylornithine aminotransferase; Provisional; Region: PRK02627 273068008689 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 273068008690 inhibitor-cofactor binding pocket; inhibition site 273068008691 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068008692 catalytic residue [active] 273068008693 Pfam match to entry aminotran_3, Aminotransferase class-III, score 590.4, E-value 5.70E-177 273068008694 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 273068008695 feedback inhibition sensing region; other site 273068008696 homohexameric interface [polypeptide binding]; other site 273068008697 nucleotide binding site [chemical binding]; other site 273068008698 N-acetyl-L-glutamate binding site [chemical binding]; other site 273068008699 Pfam match to entry aakinase, Amino acid kinase family, score 203.8, E-value 2.70E-57 273068008700 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 273068008701 heterotetramer interface [polypeptide binding]; other site 273068008702 active site pocket [active] 273068008703 cleavage site 273068008704 Pfam match to entry ArgJ, ArgJ family, score 723.5, E-value 9.40E-214 273068008705 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 273068008706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068008707 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 273068008708 Pfam match to entry Semialdhyde_dhC, Semialdehyde dehydrogenase, dimerisation domain, score 128.9, E-value 9.00E-35 273068008709 Pfam match to entry Semialdhyde_dh, Semialdehyde dehydrogenase, NAD binding domain, score 141.2, E-value 1.30E-44 273068008710 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068008711 putative substrate translocation pore; other site 273068008712 sugar efflux transporter; Region: 2A0120; TIGR00899 273068008713 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273068008714 dimerization interface [polypeptide binding]; other site 273068008715 putative DNA binding site [nucleotide binding]; other site 273068008716 putative Zn2+ binding site [ion binding]; other site 273068008717 Pfam match to entry HTH_5, Bacterial regulatory protein, arsR family, score 47.8, E-value 2.40E-10 273068008718 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 273068008719 Bacterial transcriptional regulator; Region: IclR; pfam01614 273068008720 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273068008721 DNA binding residues [nucleotide binding] 273068008722 magnesium-transporting ATPase; Provisional; Region: PRK15122 273068008723 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 273068008724 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 273068008725 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 273068008726 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 273068008727 Pfam match to entry Hydrolase, haloacid dehalogenase-like hydrolase, score 58.6, E-value 1.30E-13 273068008728 Pfam match to entry E1-E2_ATPase, E1-E2 ATPase, score 270.9, E-value 3.40E-81 273068008729 Pfam match to entry Cation_ATPase_N, Cation transporter/ATPase, N-terminus, score 58.4, E-value 1.50E-13 273068008730 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 273068008731 active site 273068008732 Pfam match to entry PAP2, PAP2 superfamily, score 82.3, E-value 9.70E-21 273068008733 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 273068008734 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068008735 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068008736 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 273068008737 Walker A/P-loop; other site 273068008738 ATP binding site [chemical binding]; other site 273068008739 Q-loop/lid; other site 273068008740 ABC transporter signature motif; other site 273068008741 Walker B; other site 273068008742 D-loop; other site 273068008743 H-loop/switch region; other site 273068008744 Pfam match to entry ABC_tran, ABC transporter, score 197.7, E-value 1.80E-55 273068008745 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 181.4, E-value 1.50E-50 273068008746 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068008747 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068008748 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068008749 Walker A/P-loop; other site 273068008750 ATP binding site [chemical binding]; other site 273068008751 Q-loop/lid; other site 273068008752 ABC transporter signature motif; other site 273068008753 Walker B; other site 273068008754 D-loop; other site 273068008755 H-loop/switch region; other site 273068008756 Pfam match to entry ABC_tran, ABC transporter, score 206.6, E-value 3.90E-58 273068008757 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 107.1, E-value 3.30E-28 273068008758 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 273068008759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 273068008760 putative DNA binding site [nucleotide binding]; other site 273068008761 putative Zn2+ binding site [ion binding]; other site 273068008762 Pfam match to entry MarR, MarR family, score 103.5, E-value 4.20E-27 273068008763 hypothetical protein; Provisional; Region: PRK08609 273068008764 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 273068008765 active site 273068008766 primer binding site [nucleotide binding]; other site 273068008767 NTP binding site [chemical binding]; other site 273068008768 metal binding triad [ion binding]; metal-binding site 273068008769 Pfam match to entry PHP_C, PHP domain C-terminal region, score 65, E-value 1.60E-15 273068008770 Pfam match to entry PHP_N, PHP domain N-terminal region, score 86, E-value 7.70E-22 273068008771 Pfam match to entry DNA_polymeraseX, DNA polymerase X family, score 132.3, E-value 8.60E-36 273068008772 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 273068008773 active site 273068008774 NTP binding site [chemical binding]; other site 273068008775 metal binding triad [ion binding]; metal-binding site 273068008776 Pfam match to entry NTP_transf_2, Nucleotidyltransferase domain, score 35, E-value 1.70E-06 273068008777 Transposase [DNA replication, recombination, and repair]; Region: COG5421 273068008778 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 273068008779 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 273068008780 DNA binding site [nucleotide binding] 273068008781 active site 273068008782 Pfam match to entry Methyltransf_1, 6-O-methylguanine DNA methyltransferase, DNA binding domain, score 161.9, E-value 1.10E-44 273068008783 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 273068008784 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 273068008785 active site 273068008786 catalytic tetrad [active] 273068008787 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273068008788 Pfam match to entry aldo_ket_red, Aldo/keto reductase family, score 73.9, E-value 3.10E-21 273068008789 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 273068008790 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 273068008791 Pfam match to entry SBP_bac_5, Bacterial extracellular solute-binding proteins, family 5, score 336, E-value 4.30E-97 273068008792 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 273068008793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068008794 dimer interface [polypeptide binding]; other site 273068008795 conserved gate region; other site 273068008796 putative PBP binding loops; other site 273068008797 ABC-ATPase subunit interface; other site 273068008798 Pfam match to entry BPD_transp, Binding-protein-dependent transport systems inner membrane component, score 46.3, E-value 6.90E-10 273068008799 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 273068008800 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 273068008801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 273068008802 dimer interface [polypeptide binding]; other site 273068008803 conserved gate region; other site 273068008804 putative PBP binding loops; other site 273068008805 ABC-ATPase subunit interface; other site 273068008806 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 273068008807 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068008808 Walker A/P-loop; other site 273068008809 ATP binding site [chemical binding]; other site 273068008810 Q-loop/lid; other site 273068008811 ABC transporter signature motif; other site 273068008812 Walker B; other site 273068008813 D-loop; other site 273068008814 H-loop/switch region; other site 273068008815 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068008816 Pfam match to entry ABC_tran, ABC transporter, score 220.2, E-value 3.00E-62 273068008817 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 273068008818 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 273068008819 Walker A/P-loop; other site 273068008820 ATP binding site [chemical binding]; other site 273068008821 Q-loop/lid; other site 273068008822 ABC transporter signature motif; other site 273068008823 Walker B; other site 273068008824 D-loop; other site 273068008825 H-loop/switch region; other site 273068008826 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 273068008827 Pfam match to entry ABC_tran, ABC transporter, score 218.2, E-value 1.20E-61 273068008828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068008829 Major Facilitator Superfamily; Region: MFS_1; pfam07690 273068008830 putative substrate translocation pore; other site 273068008831 Transposase IS200 like; Region: Y1_Tnp; cl00848 273068008832 Helix-turn-helix domains; Region: HTH; cl00088 273068008833 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 273068008834 ABC-2 type transporter; Region: ABC2_membrane; cl11417 273068008835 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 273068008836 ABC-2 type transporter; Region: ABC2_membrane; cl11417 273068008837 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068008838 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 273068008839 Walker A/P-loop; other site 273068008840 ATP binding site [chemical binding]; other site 273068008841 Q-loop/lid; other site 273068008842 ABC transporter signature motif; other site 273068008843 Walker B; other site 273068008844 D-loop; other site 273068008845 H-loop/switch region; other site 273068008846 Pfam match to entry ABC_tran, ABC transporter, score 209.7, E-value 4.60E-59 273068008847 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068008848 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 273068008849 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 273068008850 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 273068008851 active site 273068008852 HIGH motif; other site 273068008853 KMSK motif region; other site 273068008854 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 273068008855 tRNA binding surface [nucleotide binding]; other site 273068008856 anticodon binding site; other site 273068008857 Pfam match to entry tRNA-synt_1d, tRNA synthetases class I (R), score 476.1, E-value 2.70E-139 273068008858 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 273068008859 D-alanyl-D-alanine carboxypeptidase; Region: VanY; cl00813 273068008860 Pfam match to entry Peptidase_M45, D-ala-D-ala dipeptidase, score 72.8, E-value 4.10E-19 273068008861 Amino acid permease; Region: AA_permease; cl00524 273068008862 Pfam match to entry aa_permeases, Amino acid permease, score -124.1, E-value 5.10E-08 273068008863 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 273068008864 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 273068008865 Carbon starvation protein CstA; Region: CstA; cl00856 273068008866 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 273068008867 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 273068008868 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 273068008869 Pfam match to entry Dala_Dala_ligas, D-ala D-ala ligase, score 414.1, E-value 1.30E-120 273068008870 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 273068008871 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273068008872 Pfam match to entry Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 65.9, E-value 8.70E-16 273068008873 Pfam match to entry Mur_ligase, Mur ligase family, catalytic domain, score 134.7, E-value 6.80E-39 273068008874 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 273068008875 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 273068008876 Pfam match to entry abhydrolase, alpha/beta hydrolase fold, score 109.8, E-value 5.30E-29 273068008877 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 273068008878 Pfam match to entry SASP, Small, acid-soluble spore proteins, alpha/beta type, score 49.6, E-value 2.30E-12 273068008879 germination protein YpeB; Region: spore_YpeB; TIGR02889 273068008880 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 273068008881 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 273068008882 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068008883 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 273068008884 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 67.5, E-value 2.90E-16 273068008885 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 273068008886 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 273068008887 Amino acid permease; Region: AA_permease; cl00524 273068008888 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 273068008889 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 273068008890 active site 273068008891 Transcriptional regulators [Transcription]; Region: GntR; COG1802 273068008892 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 273068008893 DNA-binding site [nucleotide binding]; DNA binding site 273068008894 FCD domain; Region: FCD; cl11656 273068008895 Pfam match to entry gntR, Bacterial regulatory proteins, gntR family, score 70.1, E-value 4.20E-20 273068008896 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 273068008897 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273068008898 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273068008899 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 273068008900 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 273068008901 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 273068008902 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068008903 putative peptidoglycan binding site; other site 273068008904 Pfam match to entry LysM, LysM domain, score 58.8, E-value 1.20E-13 273068008905 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 273068008906 YabG peptidase U57; Region: Peptidase_U57; cl05250 273068008907 stage V sporulation protein T; Region: spore_V_T; TIGR02851 273068008908 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 273068008909 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 273068008910 SurA N-terminal domain; Region: SurA_N; pfam09312 273068008911 PPIC-type PPIASE domain; Region: Rotamase; cl08278 273068008912 Pfam match to entry Rotamase, PPIC-type PPIASE domain., score 146.7, E-value 4.00E-40 273068008913 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 273068008914 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 273068008915 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 273068008916 ATP binding site [chemical binding]; other site 273068008917 putative Mg++ binding site [ion binding]; other site 273068008918 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 273068008919 nucleotide binding region [chemical binding]; other site 273068008920 ATP-binding site [chemical binding]; other site 273068008921 TRCF domain; Region: TRCF; cl04088 273068008922 Pfam match to entry helicase_C, Helicase conserved C-terminal domain, score 95, E-value 1.50E-24 273068008923 Pfam match to entry DEAD, DEAD/DEAH box helicase, score 104.5, E-value 3.90E-32 273068008924 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 273068008925 putative active site [active] 273068008926 catalytic residue [active] 273068008927 Pfam match to entry Pept_tRNA_hydro, Peptidyl-tRNA hydrolase, score 290.5, E-value 2.20E-83 273068008928 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 273068008929 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273068008930 protein binding site [polypeptide binding]; other site 273068008931 Pfam match to entry PDZ, PDZ domain (Also known as DHR or GLGF)., score 51.3, E-value 2.20E-11 273068008932 Pfam match to entry trypsin, Trypsin, score 77.1, E-value 1.30E-23 273068008933 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 273068008934 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068008935 dimerization interface [polypeptide binding]; other site 273068008936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068008937 dimer interface [polypeptide binding]; other site 273068008938 phosphorylation site [posttranslational modification] 273068008939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068008940 ATP binding site [chemical binding]; other site 273068008941 Mg2+ binding site [ion binding]; other site 273068008942 G-X-G motif; other site 273068008943 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 162.9, E-value 5.20E-45 273068008944 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 93.4, E-value 4.40E-24 273068008945 Pfam match to entry HAMP, HAMP domain, score 60.7, E-value 3.10E-14 273068008946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273068008947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068008948 active site 273068008949 phosphorylation site [posttranslational modification] 273068008950 intermolecular recognition site; other site 273068008951 dimerization interface [polypeptide binding]; other site 273068008952 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273068008953 DNA binding site [nucleotide binding] 273068008954 Pfam match to entry trans_reg_C, Transcriptional regulatory protein, C terminal, score 119.5, E-value 1.80E-34 273068008955 Pfam match to entry response_reg, Response regulator receiver domain, score 140.2, E-value 3.70E-38 273068008956 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 273068008957 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068008958 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 138.2, E-value 1.40E-37 273068008959 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 273068008960 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 273068008961 Substrate binding site; other site 273068008962 Mg++ binding site; other site 273068008963 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 273068008964 active site 273068008965 substrate binding site [chemical binding]; other site 273068008966 CoA binding site [chemical binding]; other site 273068008967 Pfam match to entry NTP_transferase, Nucleotidyl transferase, score 31.6, E-value 4.50E-08 273068008968 SpoVG; Region: SpoVG; cl00915 273068008969 pur operon repressor, Bacillus subtilis type; Region: purR_Bsub; TIGR01743 273068008970 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 273068008971 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 273068008972 Pfam match to entry Pribosyltran, Phosphoribosyl transferase domain, score 70.1, E-value 4.60E-17 273068008973 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 273068008974 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 273068008975 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 273068008976 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273068008977 Pfam match to entry Mur_ligase, Mur ligase family, catalytic domain, score 223.1, E-value 5.50E-65 273068008978 Pfam match to entry Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 114.5, E-value 2.00E-30 273068008979 Transcriptional regulators [Transcription]; Region: PurR; COG1609 273068008980 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 273068008981 DNA binding site [nucleotide binding] 273068008982 domain linker motif; other site 273068008983 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 273068008984 putative dimerization interface [polypeptide binding]; other site 273068008985 putative ligand binding site [chemical binding]; other site 273068008986 Pfam match to entry Peripla_BP_like, Periplasmic binding proteins and sugar binding domain of the LacI family., score 150.3, E-value 3.40E-41 273068008987 Pfam match to entry lacI, Bacterial regulatory proteins, lacI family, score 40.8, E-value 4.50E-10 273068008988 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 273068008989 Pfam match to entry Abi, CAAX amino terminal protease family, score 66.7, E-value 4.90E-16 273068008990 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 273068008991 putative dimer interface [polypeptide binding]; other site 273068008992 Pfam match to entry HSP20, Hsp20/alpha crystallin family, score 101.8, E-value 5.00E-27 273068008993 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 273068008994 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 273068008995 putative active site [active] 273068008996 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 273068008997 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 273068008998 P-loop; other site 273068008999 active site 273068009000 phosphorylation site [posttranslational modification] 273068009001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 273068009002 Pfam match to entry PTS_EIIC, Phosphotransferase system, EIIC, score 196.4, E-value 4.30E-55 273068009003 Pfam match to entry PTS_IIB_fruc, PTS system, Fructose specific IIB subunit, score 217.1, E-value 2.60E-61 273068009004 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 273068009005 active site 273068009006 phosphorylation site [posttranslational modification] 273068009007 Pfam match to entry PTS_EIIA_2, Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2, score 72.8, E-value 7.00E-18 273068009008 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 273068009009 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 273068009010 putative substrate binding site [chemical binding]; other site 273068009011 putative ATP binding site [chemical binding]; other site 273068009012 Pfam match to entry pfkB, pfkB family carbohydrate kinase, score 203.3, E-value 3.60E-57 273068009013 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 273068009014 Helix-turn-helix domains; Region: HTH; cl00088 273068009015 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 273068009016 Pfam match to entry deoR, Bacterial regulatory proteins, deoR family, score 288.1, E-value 1.10E-82 273068009017 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 273068009018 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 273068009019 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 273068009020 Pfam match to entry Hydantoinase_A, Hydantoinase/oxoprolinase, score 21, E-value 4.40E-13 273068009021 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 273068009022 phosphate binding site [ion binding]; other site 273068009023 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 273068009024 L-lactate permease; Region: Lactate_perm; cl00701 273068009025 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 273068009026 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 273068009027 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 273068009028 putative active site [active] 273068009029 putative metal binding site [ion binding]; other site 273068009030 Transposase [DNA replication, recombination, and repair]; Region: COG5421 273068009031 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 273068009032 S-layer homology domain; Region: SLH; pfam00395 273068009033 S-layer homology domain; Region: SLH; pfam00395 273068009034 Pfam match to entry SLH, S-layer homology domain, score 35.4, E-value 1.30E-06 273068009035 Pfam match to entry SLH, S-layer homology domain, score 57.5, E-value 3.00E-13 273068009036 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 273068009037 Bacterial SH3 domain; Region: SH3_3; cl02551 273068009038 Bacterial SH3 domain; Region: SH3_3; cl02551 273068009039 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 273068009040 Pfam match to entry DUF132, Protein of unknown function DUF132, score 18.5, E-value 7.90E-07 273068009041 Phd_YefM; Region: PhdYeFM; cl09153 273068009042 CTP synthetase; Validated; Region: pyrG; PRK05380 273068009043 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 273068009044 Catalytic site [active] 273068009045 active site 273068009046 UTP binding site [chemical binding]; other site 273068009047 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 273068009048 active site 273068009049 putative oxyanion hole; other site 273068009050 catalytic triad [active] 273068009051 Pfam match to entry GATase, Glutamine amidotransferase class-I, score 265.9, E-value 5.50E-76 273068009052 histidinol-phosphatase; Provisional; Region: PRK07328 273068009053 Pfam match to entry PHP_C, PHP domain C-terminal region, score 43.5, E-value 4.70E-09 273068009054 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 273068009055 Pfam match to entry DUF79, Protein of unknown function DUF79, score 45.6, E-value 1.10E-09 273068009056 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 273068009057 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068009058 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 273068009059 putative L-serine binding site [chemical binding]; other site 273068009060 Pfam match to entry ACT, ACT domain, score 52.3, E-value 1.10E-11 273068009061 Pfam match to entry 2-Hacid_DH_C, D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain, score 248.3, E-value 1.10E-70 273068009062 Pfam match to entry 2-Hacid_DH, D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain, score 64.3, E-value 2.60E-15 273068009063 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 273068009064 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 273068009065 homodimer interface [polypeptide binding]; other site 273068009066 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068009067 catalytic residue [active] 273068009068 Pfam match to entry aminotran_5, Aminotransferase class-V, score 114.6, E-value 1.80E-30 273068009069 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 273068009070 putative active site [active] 273068009071 catalytic triad [active] 273068009072 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 273068009073 putative integrin binding motif; other site 273068009074 PA/protease domain interface [polypeptide binding]; other site 273068009075 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 273068009076 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 273068009077 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 273068009078 S-layer homology domain; Region: SLH; pfam00395 273068009079 S-layer homology domain; Region: SLH; pfam00395 273068009080 S-layer homology domain; Region: SLH; pfam00395 273068009081 Pfam match to entry SLH, S-layer homology domain, score 59.3, E-value 8.50E-14 273068009082 Pfam match to entry SLH, S-layer homology domain, score 52.4, E-value 1.00E-11 273068009083 Pfam match to entry SLH, S-layer homology domain, score 62.7, E-value 7.70E-15 273068009084 Pfam match to entry Big_2, Bacterial Ig-like domain (group 2), score 58.2, E-value 1.80E-13 273068009085 Pfam match to entry Peptidase_S8, Subtilase family, score 113, E-value 2.10E-30 273068009086 Pfam match to entry PA, PA domain, score 72, E-value 1.30E-17 273068009087 Glycerate kinase family; Region: Gly_kinase; cl00841 273068009088 Pfam match to entry DUF168, Uncharacterized BCR, COG1929, score 625.1, E-value 4.10E-184 273068009089 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068009090 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 273068009091 protein binding site [polypeptide binding]; other site 273068009092 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 273068009093 Catalytic dyad [active] 273068009094 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 273068009095 Pfam match to entry PG_binding_1, Putative peptidoglycan binding domain, score 70.4, E-value 3.70E-17 273068009096 homoserine kinase; Provisional; Region: PRK01212 273068009097 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 273068009098 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 273068009099 Pfam match to entry GHMP_kinases, GHMP kinases putative ATP-binding protein, score 53.8, E-value 8.90E-14 273068009100 threonine synthase; Reviewed; Region: PRK06721 273068009101 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 273068009102 homodimer interface [polypeptide binding]; other site 273068009103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 273068009104 catalytic residue [active] 273068009105 Pfam match to entry PALP, Pyridoxal-phosphate dependent enzyme, score 337.6, E-value 1.40E-97 273068009106 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068009107 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 273068009108 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 273068009109 Pfam match to entry ACT, ACT domain, score 55.7, E-value 1.00E-12 273068009110 Pfam match to entry Homoserine_dh, Homoserine dehydrogenase, score 435, E-value 6.80E-127 273068009111 hypothetical protein; Provisional; Region: PRK04435 273068009112 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 273068009113 Pfam match to entry ACT, ACT domain, score 38.6, E-value 1.40E-07 273068009114 Amino acid permease; Region: AA_permease; cl00524 273068009115 Pfam match to entry aa_permeases, Amino acid permease, score -26.1, E-value 1.30E-11 273068009116 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 273068009117 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 273068009118 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 273068009119 active site 273068009120 FMN binding site [chemical binding]; other site 273068009121 substrate binding site [chemical binding]; other site 273068009122 putative catalytic residue [active] 273068009123 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273068009124 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 273068009125 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 94, E-value 2.90E-24 273068009126 Pfam match to entry oxidored_FMN, NADH:flavin oxidoreductase / NADH oxidase family, score 344.6, E-value 1.10E-99 273068009127 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 273068009128 active site 273068009129 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 273068009130 Putative cyclase; Region: Cyclase; cl00814 273068009131 EamA-like transporter family; Region: EamA; cl01037 273068009132 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 273068009133 EamA-like transporter family; Region: EamA; cl01037 273068009134 Pfam match to entry DUF6, Integral membrane protein DUF6, score 99.7, E-value 5.80E-26 273068009135 Pfam match to entry DUF6, Integral membrane protein DUF6, score 86.7, E-value 4.70E-22 273068009136 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 273068009137 Pfam match to entry SpoU_methylase, SpoU rRNA Methylase family, score 109.3, E-value 7.50E-29 273068009138 CRISPR/Cas system-associated RAMP superfamily protein Cmr6; Region: Cmr6_III-B; cd09661 273068009139 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09654 273068009140 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 273068009141 CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700 273068009142 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09656 273068009143 CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cd09657 273068009144 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09660 273068009145 CRISPR-associated protein, MJ1666 family; Region: cas_MJ1666; TIGR01897 273068009146 Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216 273068009147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 273068009148 Integrase core domain; Region: rve; cl01316 273068009149 Pfam match to entry rve, Integrase core domain, score 30.7, E-value 1.00E-07 273068009150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 273068009151 Transposase; Region: DEDD_Tnp_IS110; pfam01548 273068009152 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 273068009153 Pfam match to entry Transposase_20, Transposase IS116/IS110/IS902 family, score 76.1, E-value 7.20E-19 273068009154 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 273068009155 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 273068009156 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 273068009157 VanW like protein; Region: VanW; pfam04294 273068009158 Transposase domain (DUF772); Region: DUF772; cl15789 273068009159 Transposase domain (DUF772); Region: DUF772; cl15789 273068009160 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 273068009161 Pfam match to entry DUF196, Uncharacterized ACR, COG1343, score 100.8, E-value 2.70E-26 273068009162 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 273068009163 Pfam match to entry DUF48, Protein of unknown function DUF48, score 384.8, E-value 8.90E-112 273068009164 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637 273068009165 Pfam match to entry DUF83, Domain of unknown function DUF83, score 68.9, E-value 1.10E-16 273068009166 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 273068009167 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068009168 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 273068009169 Pfam match to entry DEAD, DEAD/DEAH box helicase, score 27.7, E-value 7.20E-08 273068009170 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 273068009171 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 273068009172 Pfam match to entry DUF57, Protein of unknown function DUF57, score 38.8, E-value 1.20E-09 273068009173 CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766 273068009174 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741 273068009175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273068009176 DNA binding residues [nucleotide binding] 273068009177 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 273068009178 Pfam match to entry DUF57, Protein of unknown function DUF57, score 69, E-value 1.00E-16 273068009179 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 273068009180 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 273068009181 active site 273068009182 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 273068009183 trimerization site [polypeptide binding]; other site 273068009184 active site 273068009185 Pfam match to entry NifU_N, NifU-like N terminal domain, score 83.1, E-value 5.50E-21 273068009186 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 273068009187 Aminotransferase class-V; Region: Aminotran_5; pfam00266 273068009188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273068009189 catalytic residue [active] 273068009190 Pfam match to entry aminotran_5, Aminotransferase class-V, score 27, E-value 1.20E-08 273068009191 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 273068009192 Pfam match to entry UPF0051, Uncharacterized protein family (UPF0051), score 79.9, E-value 5.30E-20 273068009193 FeS assembly protein SufB; Region: sufB; TIGR01980 273068009194 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 273068009195 Pfam match to entry UPF0051, Uncharacterized protein family (UPF0051), score 398.2, E-value 7.80E-116 273068009196 FeS assembly ATPase SufC; Region: sufC; TIGR01978 273068009197 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 273068009198 Walker A/P-loop; other site 273068009199 ATP binding site [chemical binding]; other site 273068009200 Q-loop/lid; other site 273068009201 ABC transporter signature motif; other site 273068009202 Walker B; other site 273068009203 D-loop; other site 273068009204 H-loop/switch region; other site 273068009205 Pfam match to entry ABC_tran, ABC transporter, score 108.8, E-value 1.10E-28 273068009206 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 273068009207 oligomerisation interface [polypeptide binding]; other site 273068009208 mobile loop; other site 273068009209 roof hairpin; other site 273068009210 Pfam match to entry cpn10, Chaperonin 10 Kd subunit, score 59.4, E-value 3.40E-15 273068009211 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 273068009212 catalytic residues [active] 273068009213 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 273068009214 catalytic residues [active] 273068009215 Pfam match to entry glutaredoxin, Glutaredoxin, score 43.3, E-value 5.30E-09 273068009216 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 273068009217 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 273068009218 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 273068009219 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 273068009220 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 273068009221 active site 273068009222 HIGH motif; other site 273068009223 dimer interface [polypeptide binding]; other site 273068009224 KMSKS motif; other site 273068009225 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 273068009226 Pfam match to entry tRNA-synt_1b, tRNA synthetases class I (W and Y), score 380.8, E-value 1.40E-110 273068009227 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 273068009228 Pfam match to entry DUF163, Uncharacterized ACR, COG1576, score 20.3, E-value 4.20E-06 273068009229 Uncharacterized conserved protein [Function unknown]; Region: COG1576; cl00679 273068009230 Pfam match to entry DUF163, Uncharacterized ACR, COG1576, score 133.6, E-value 3.60E-36 273068009231 YyzF-like protein; Region: YyzF; cl15733 273068009232 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 273068009233 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 273068009234 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 273068009235 protein binding site [polypeptide binding]; other site 273068009236 Pfam match to entry PDZ, PDZ domain (Also known as DHR or GLGF)., score 40.2, E-value 4.80E-08 273068009237 Pfam match to entry trypsin, Trypsin, score 71.7, E-value 6.70E-22 273068009238 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 273068009239 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 273068009240 hinge; other site 273068009241 active site 273068009242 Pfam match to entry EPSP_syntase, EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase), score 411.2, E-value 9.80E-120 273068009243 YycH protein; Region: YycI; cl02015 273068009244 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 273068009245 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 273068009246 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 273068009247 dimerization interface [polypeptide binding]; other site 273068009248 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 273068009249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 273068009250 dimer interface [polypeptide binding]; other site 273068009251 phosphorylation site [posttranslational modification] 273068009252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 273068009253 ATP binding site [chemical binding]; other site 273068009254 Mg2+ binding site [ion binding]; other site 273068009255 G-X-G motif; other site 273068009256 Pfam match to entry HATPase_c, Histidine kinase-, DNA gyrase B-, phytochrome-like ATPase, score 185.8, E-value 7.00E-52 273068009257 Pfam match to entry signal, His Kinase A (phosphoacceptor) domain, score 84.9, E-value 1.70E-21 273068009258 Pfam match to entry HAMP, HAMP domain, score 48.4, E-value 1.60E-10 273068009259 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 273068009260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 273068009261 active site 273068009262 phosphorylation site [posttranslational modification] 273068009263 intermolecular recognition site; other site 273068009264 dimerization interface [polypeptide binding]; other site 273068009265 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 273068009266 DNA binding site [nucleotide binding] 273068009267 Pfam match to entry trans_reg_C, Transcriptional regulatory protein, C terminal, score 129, E-value 2.60E-37 273068009268 Pfam match to entry response_reg, Response regulator receiver domain, score 149.8, E-value 4.70E-41 273068009269 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 273068009270 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 273068009271 putative peptidoglycan binding site; other site 273068009272 G5 domain; Region: G5; pfam07501 273068009273 Peptidase family M23; Region: Peptidase_M23; pfam01551 273068009274 Pfam match to entry Peptidase_M37, Peptidase family M23/M37, score 161.1, E-value 1.90E-44 273068009275 Pfam match to entry LysM, LysM domain, score 50.7, E-value 3.20E-11 273068009276 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 273068009277 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 273068009278 DNA replication protein DnaC; Validated; Region: PRK06835 273068009279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 273068009280 Walker A motif; other site 273068009281 ATP binding site [chemical binding]; other site 273068009282 Walker B motif; other site 273068009283 arginine finger; other site 273068009284 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 273068009285 Zn binding site [ion binding]; other site 273068009286 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 273068009287 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 273068009288 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 273068009289 GDP-binding site [chemical binding]; other site 273068009290 ACT binding site; other site 273068009291 IMP binding site; other site 273068009292 Pfam match to entry Adenylsucc_synt, Adenylosuccinate synthetase, score 898.7, E-value 1.80E-266 273068009293 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 273068009294 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 273068009295 Peptidase C26; Region: Peptidase_C26; pfam07722 273068009296 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 273068009297 catalytic triad [active] 273068009298 Uncharacterized conserved protein [Function unknown]; Region: COG1284 273068009299 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 273068009300 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 273068009301 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 273068009302 Pfam match to entry DUF161, Uncharacterized BCR, YitT family COG1284, score 240.4, E-value 2.50E-68 273068009303 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 273068009304 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068009305 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 273068009306 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 273068009307 Pfam match to entry pyr_redox_dim, Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain, score 34.8, E-value 8.50E-07 273068009308 Pfam match to entry pyr_redox, Pyridine nucleotide-disulphide oxidoreductase, score 282, E-value 7.40E-81 273068009309 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 273068009310 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 273068009311 putative active site [active] 273068009312 putative metal binding site [ion binding]; other site 273068009313 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 273068009314 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 273068009315 active site 273068009316 substrate binding site [chemical binding]; other site 273068009317 metal binding site [ion binding]; metal-binding site 273068009318 Pfam match to entry PGM_PMM_I, Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I, score 77.3, E-value 3.20E-19 273068009319 oligoendopeptidase F; Region: pepF; TIGR00181 273068009320 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 273068009321 active site 273068009322 Zn binding site [ion binding]; other site 273068009323 Pfam match to entry Peptidase_M3, Peptidase family M3, score 102.6, E-value 7.90E-27 273068009324 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 273068009325 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 273068009326 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 273068009327 putative NAD(P) binding site [chemical binding]; other site 273068009328 putative active site [active] 273068009329 Pfam match to entry adh_short, short chain dehydrogenase, score 148, E-value 1.60E-40 273068009330 Pfam match to entry adh_short_C2, Short chain dehydrogenase/reductase C-terminus, score 47.7, E-value 7.00E-12 273068009331 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273068009332 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 273068009333 Walker A/P-loop; other site 273068009334 ATP binding site [chemical binding]; other site 273068009335 Q-loop/lid; other site 273068009336 ABC transporter signature motif; other site 273068009337 Walker B; other site 273068009338 D-loop; other site 273068009339 H-loop/switch region; other site 273068009340 Pfam match to entry ABC_tran, ABC transporter, score 221.5, E-value 1.30E-62 273068009341 FtsX-like permease family; Region: FtsX; pfam02687 273068009342 FtsX-like permease family; Region: FtsX; pfam02687 273068009343 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273068009344 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 273068009345 Walker A/P-loop; other site 273068009346 ATP binding site [chemical binding]; other site 273068009347 Q-loop/lid; other site 273068009348 ABC transporter signature motif; other site 273068009349 Walker B; other site 273068009350 D-loop; other site 273068009351 H-loop/switch region; other site 273068009352 Pfam match to entry ABC_tran, ABC transporter, score 192, E-value 9.60E-54 273068009353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 273068009354 S-adenosylmethionine binding site [chemical binding]; other site 273068009355 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068009356 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068009357 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 273068009358 Walker A/P-loop; other site 273068009359 ATP binding site [chemical binding]; other site 273068009360 Q-loop/lid; other site 273068009361 ABC transporter signature motif; other site 273068009362 Walker B; other site 273068009363 D-loop; other site 273068009364 H-loop/switch region; other site 273068009365 Pfam match to entry ABC_tran, ABC transporter, score 160, E-value 3.90E-44 273068009366 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 34, E-value 3.50E-06 273068009367 Helix-turn-helix domains; Region: HTH; cl00088 273068009368 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 273068009369 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 273068009370 active site pocket [active] 273068009371 oxyanion hole [active] 273068009372 catalytic triad [active] 273068009373 active site nucleophile [active] 273068009374 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 273068009375 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 273068009376 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 273068009377 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 273068009378 Pfam match to entry PmbA_TldD, Putative modulator of DNA gyrase, score 137.3, E-value 2.80E-37 273068009379 Helix-turn-helix domains; Region: HTH; cl00088 273068009380 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 273068009381 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068009382 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068009383 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068009384 Walker A/P-loop; other site 273068009385 ATP binding site [chemical binding]; other site 273068009386 Q-loop/lid; other site 273068009387 ABC transporter signature motif; other site 273068009388 Walker B; other site 273068009389 D-loop; other site 273068009390 H-loop/switch region; other site 273068009391 Pfam match to entry ABC_tran, ABC transporter, score 175, E-value 1.20E-48 273068009392 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 273068009393 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 273068009394 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 273068009395 Protein of unknown function (DUF990); Region: DUF990; cl01496 273068009396 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 273068009397 Similar in sequence to NatA, this is the ATPase component of a bacterial ABC-type Na+ transport system called NatAB, which catalyzes ATP-dependent electrogenic Na+ extrusion without mechanically coupled to proton or K+ uptake. NatB possess six putative...; Region: ABC_NatA_like; cd03267 273068009398 Walker A/P-loop; other site 273068009399 ATP binding site [chemical binding]; other site 273068009400 Q-loop/lid; other site 273068009401 ABC transporter signature motif; other site 273068009402 Walker B; other site 273068009403 D-loop; other site 273068009404 H-loop/switch region; other site 273068009405 Pfam match to entry ABC_tran, ABC transporter, score 146.8, E-value 3.90E-40 273068009406 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068009407 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068009408 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068009409 Walker A/P-loop; other site 273068009410 ATP binding site [chemical binding]; other site 273068009411 Q-loop/lid; other site 273068009412 ABC transporter signature motif; other site 273068009413 Walker B; other site 273068009414 D-loop; other site 273068009415 H-loop/switch region; other site 273068009416 Pfam match to entry ABC_tran, ABC transporter, score 173.7, E-value 3.00E-48 273068009417 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 74.4, E-value 2.40E-18 273068009418 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068009419 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 273068009420 Active site serine [active] 273068009421 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 273068009422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 273068009423 FeS/SAM binding site; other site 273068009424 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; cl14869 273068009425 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 273068009426 dimerization interface [polypeptide binding]; other site 273068009427 DNA binding residues [nucleotide binding] 273068009428 Pfam match to entry GerE, Bacterial regulatory proteins, luxR family, score 36.2, E-value 7.60E-07 273068009429 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 273068009430 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 273068009431 putative substrate translocation pore; other site 273068009432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068009433 D-loop; other site 273068009434 H-loop/switch region; other site 273068009435 peptide-modifying radical SAM enzyme CbpB; Region: rSAM_cobopep; TIGR04163 273068009436 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068009437 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 273068009438 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 273068009439 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 273068009440 Walker A/P-loop; other site 273068009441 ATP binding site [chemical binding]; other site 273068009442 Q-loop/lid; other site 273068009443 ABC transporter signature motif; other site 273068009444 Walker B; other site 273068009445 D-loop; other site 273068009446 H-loop/switch region; other site 273068009447 Pfam match to entry ABC_tran, ABC transporter, score 187.6, E-value 2.00E-52 273068009448 Pfam match to entry ABC_membrane, ABC transporter transmembrane region., score 96.4, E-value 5.50E-25 273068009449 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 273068009450 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 273068009451 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 273068009452 non-specific DNA binding site [nucleotide binding]; other site 273068009453 salt bridge; other site 273068009454 sequence-specific DNA binding site [nucleotide binding]; other site 273068009455 Pfam match to entry HTH_3, Helix-turn-helix, score 55.8, E-value 9.60E-13 273068009456 hybrid cluster protein; Provisional; Region: PRK05290 273068009457 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 273068009458 ACS interaction site; other site 273068009459 CODH interaction site; other site 273068009460 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 273068009461 hybrid metal cluster; other site 273068009462 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 273068009463 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 273068009464 ligand binding site [chemical binding]; other site 273068009465 flexible hinge region; other site 273068009466 Helix-turn-helix domains; Region: HTH; cl00088 273068009467 Pfam match to entry crp, Bacterial regulatory proteins, crp family, score 31.2, E-value 9.70E-09 273068009468 Pfam match to entry cNMP_binding, Cyclic nucleotide-binding domain, score 85.6, E-value 1.00E-21 273068009469 replicative DNA helicase; Region: DnaB; TIGR00665 273068009470 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 273068009471 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 273068009472 Walker A motif; other site 273068009473 ATP binding site [chemical binding]; other site 273068009474 Walker B motif; other site 273068009475 DNA binding loops [nucleotide binding] 273068009476 Pfam match to entry DnaB, DnaB-like helicase, score 605.9, E-value 6.10E-191 273068009477 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 273068009478 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 273068009479 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 273068009480 Pfam match to entry Ribosomal_L9, Ribosomal protein L9, score 220.2, E-value 3.10E-62 273068009481 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 273068009482 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 273068009483 DHH family; Region: DHH; pfam01368 273068009484 DHHA1 domain; Region: DHHA1; pfam02272 273068009485 Pfam match to entry DHH, DHH family, score 89.8, E-value 5.40E-23 273068009486 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 273068009487 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 273068009488 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 273068009489 Pfam match to entry Ribosomal_S18, Ribosomal protein S18, score 114.1, E-value 2.60E-30 273068009490 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 273068009491 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 273068009492 dimer interface [polypeptide binding]; other site 273068009493 ssDNA binding site [nucleotide binding]; other site 273068009494 tetramer (dimer of dimers) interface [polypeptide binding]; other site 273068009495 Pfam match to entry SSB, Single-strand binding protein family, score 155.4, E-value 2.90E-45 273068009496 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 273068009497 Pfam match to entry Ribosomal_S6, Ribosomal protein S6, score 132.2, E-value 9.50E-36 273068009498 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 273068009499 Mechanosensitive ion channel; Region: MS_channel; pfam00924 273068009500 Pfam match to entry UPF0003, Uncharacterized protein family UPF0003, score 231.4, E-value 1.30E-65 273068009501 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 273068009502 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 273068009503 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 273068009504 Mur ligase middle domain; Region: Mur_ligase_M; cl15713 273068009505 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 273068009506 Pfam match to entry Mur_ligase_C, Mur ligase family, glutamate ligase domain, score 42.8, E-value 7.50E-09 273068009507 Pfam match to entry Mur_ligase, Mur ligase family, catalytic domain, score 136, E-value 2.90E-39 273068009508 Pfam match to entry CPSase_L_D2, Carbamoyl-phosphate synthase L chain, ATP binding domain, score 33.4, E-value 1.70E-08 273068009509 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 273068009510 proposed catalytic triad [active] 273068009511 active site nucleophile [active] 273068009512 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 273068009513 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 273068009514 Pfam match to entry DAGKc, Diacylglycerol kinase catalytic domain (presumed), score 63.8, E-value 3.60E-15 273068009515 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 273068009516 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 273068009517 catalytic residue [active] 273068009518 Pfam match to entry aminotran_5, Aminotransferase class-V, score 101.9, E-value 1.30E-26 273068009519 ParB-like partition proteins; Region: parB_part; TIGR00180 273068009520 ParB-like nuclease domain; Region: ParBc; cl02129 273068009521 KorB domain; Region: KorB; pfam08535 273068009522 Pfam match to entry ParBc, ParB-like nuclease domain, score 138.1, E-value 1.60E-37 273068009523 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 273068009524 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 273068009525 P-loop; other site 273068009526 Magnesium ion binding site [ion binding]; other site 273068009527 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 273068009528 Magnesium ion binding site [ion binding]; other site 273068009529 Pfam match to entry ParA, ParA family ATPase, score 159.5, E-value 5.60E-44 273068009530 ParB-like partition proteins; Region: parB_part; TIGR00180 273068009531 ParB-like nuclease domain; Region: ParBc; cl02129 273068009532 Pfam match to entry ParBc, ParB-like nuclease domain, score 128.8, E-value 1.00E-34 273068009533 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 273068009534 nudix motif; other site 273068009535 Pfam match to entry mutT, MutT-like domain, score 85.2, E-value 1.30E-21 273068009536 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 273068009537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 273068009538 Pfam match to entry GidB, Glucose inhibited division protein, score 213, E-value 4.60E-60 273068009539 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 273068009540 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 273068009541 Pfam match to entry GIDA, Glucose inhibited division protein A, score 1221.2, E-value 0 273068009542 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 273068009543 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 273068009544 trmE is a tRNA modification GTPase; Region: trmE; cd04164 273068009545 G1 box; other site 273068009546 GTP/Mg2+ binding site [chemical binding]; other site 273068009547 Switch I region; other site 273068009548 G2 box; other site 273068009549 Switch II region; other site 273068009550 G3 box; other site 273068009551 G4 box; other site 273068009552 G5 box; other site 273068009553 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 273068009554 Pfam match to entry MMR_HSR1, GTPase of unknown function, score 29.1, E-value 8.60E-09 273068009555 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 273068009556 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 273068009557 G-X-X-G motif; other site 273068009558 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 273068009559 RxxxH motif; other site 273068009560 Pfam match to entry R3H, R3H domain, score 69.5, E-value 6.90E-17 273068009561 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 273068009562 Pfam match to entry 60KD_IMP, 60Kd inner membrane protein, score 213.5, E-value 3.20E-60 273068009563 Domain of unknown function DUF37; Region: DUF37; cl00506 273068009564 Pfam match to entry DUF37, Domain of unknown function DUF37, score 153.5, E-value 3.70E-42 273068009565 Ribonuclease P; Region: Ribonuclease_P; cl00457 273068009566 Pfam match to entry Ribonuclease_P, Ribonuclease P, score 110, E-value 4.50E-29 273068009567 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 273068009568 Pfam match to entry Ribosomal_L34, Ribosomal protein L34, score 64.3, E-value 1.80E-17