-- dump date 20120504_160300 -- class Genbank::misc_feature -- table misc_feature_note -- id note 697303000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 697303000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303000003 Walker A motif; other site 697303000004 ATP binding site [chemical binding]; other site 697303000005 Walker B motif; other site 697303000006 arginine finger; other site 697303000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 697303000008 DnaA box-binding interface [nucleotide binding]; other site 697303000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 697303000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 697303000011 putative DNA binding surface [nucleotide binding]; other site 697303000012 dimer interface [polypeptide binding]; other site 697303000013 beta-clamp/clamp loader binding surface; other site 697303000014 beta-clamp/translesion DNA polymerase binding surface; other site 697303000015 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303000016 RNA binding surface [nucleotide binding]; other site 697303000017 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 697303000018 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303000019 Walker A/P-loop; other site 697303000020 ATP binding site [chemical binding]; other site 697303000021 Q-loop/lid; other site 697303000022 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303000023 ABC transporter signature motif; other site 697303000024 Walker B; other site 697303000025 D-loop; other site 697303000026 H-loop/switch region; other site 697303000027 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 697303000028 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 697303000029 trimer interface [polypeptide binding]; other site 697303000030 active site 697303000031 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 697303000032 catalytic site [active] 697303000033 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 697303000034 catalytic triad [active] 697303000035 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 697303000036 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303000037 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 697303000038 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 697303000039 dimer interface [polypeptide binding]; other site 697303000040 putative tRNA-binding site [nucleotide binding]; other site 697303000041 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 697303000042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303000043 Mg2+ binding site [ion binding]; other site 697303000044 G-X-G motif; other site 697303000045 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 697303000046 anchoring element; other site 697303000047 dimer interface [polypeptide binding]; other site 697303000048 ATP binding site [chemical binding]; other site 697303000049 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 697303000050 active site 697303000051 putative metal-binding site [ion binding]; other site 697303000052 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 697303000053 DNA gyrase subunit A; Validated; Region: PRK05560 697303000054 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA...; Region: TOP4c; cd00187 697303000055 CAP-like domain; other site 697303000056 active site 697303000057 primary dimer interface [polypeptide binding]; other site 697303000058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697303000059 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697303000060 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697303000061 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697303000062 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697303000063 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 697303000064 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 697303000065 active site 697303000066 FMN binding site [chemical binding]; other site 697303000067 substrate binding site [chemical binding]; other site 697303000068 homotetramer interface [polypeptide binding]; other site 697303000069 catalytic residue [active] 697303000070 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 697303000071 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 697303000072 putative valine binding site [chemical binding]; other site 697303000073 dimer interface [polypeptide binding]; other site 697303000074 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 697303000075 ketol-acid reductoisomerase; Provisional; Region: PRK05479 697303000076 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000077 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 697303000078 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 697303000079 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 697303000080 active site 697303000081 catalytic residues [active] 697303000082 metal binding site [ion binding]; metal-binding site 697303000083 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 697303000084 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 697303000085 substrate binding site [chemical binding]; other site 697303000086 ligand binding site [chemical binding]; other site 697303000087 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 697303000088 substrate binding site [chemical binding]; other site 697303000089 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 697303000090 tartrate dehydrogenase; Provisional; Region: PRK08194 697303000091 6-phosphogluconate dehydratase; Region: edd; TIGR01196 697303000092 Dehydratase family; Region: ILVD_EDD; cl00340 697303000093 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 697303000094 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 697303000095 PYR/PP interface [polypeptide binding]; other site 697303000096 dimer interface [polypeptide binding]; other site 697303000097 TPP binding site [chemical binding]; other site 697303000098 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; cl00815 697303000099 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 697303000100 TPP-binding site [chemical binding]; other site 697303000101 dimer interface [polypeptide binding]; other site 697303000102 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 697303000103 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 697303000104 catalytic motif [active] 697303000105 Zn binding site [ion binding]; other site 697303000106 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl00161 697303000107 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 697303000108 Lumazine binding domain; Region: Lum_binding; pfam00677 697303000109 Lumazine binding domain; Region: Lum_binding; pfam00677 697303000110 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 697303000111 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 697303000112 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 697303000113 dimerization interface [polypeptide binding]; other site 697303000114 active site 697303000115 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 697303000116 homopentamer interface [polypeptide binding]; other site 697303000117 active site 697303000118 Domain of unknown function DUF20; Region: UPF0118; cl00465 697303000119 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 697303000120 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 697303000121 Catalytic site [active] 697303000122 seryl-tRNA synthetase; Provisional; Region: PRK05431 697303000123 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 697303000124 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme bound...; Region: SerRS_core; cd00770 697303000125 dimer interface [polypeptide binding]; other site 697303000126 active site 697303000127 motif 1; other site 697303000128 motif 2; other site 697303000129 motif 3; other site 697303000130 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 697303000131 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 697303000132 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 697303000133 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 697303000134 active site 697303000135 catalytic triad [active] 697303000136 oxyanion hole [active] 697303000137 Na+/H+ ion antiporter subunit; Region: MNHE; cl00807 697303000138 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 697303000139 Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583 697303000140 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 697303000141 Domain related to MnhB subunit of Na+/H+ antiporter; Region: MnhB; cl00676 697303000142 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 697303000143 Multicomponent K+:H+antiporter; Region: 2a6301s04; TIGR00944 697303000144 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 697303000145 NADH dehydrogenase subunit M; Validated; Region: PRK08668 697303000146 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 697303000147 NADH dehydrogenase; Region: NADHdh; cl00469 697303000148 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 697303000149 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 697303000150 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 697303000151 putative oxidoreductase; Provisional; Region: PRK13984 697303000152 4Fe-4S binding domain; Region: Fer4; cl02805 697303000153 4Fe-4S binding domain; Region: Fer4; cl02805 697303000154 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 697303000155 Carbon starvation protein CstA; Region: CstA; cl00856 697303000156 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 697303000157 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 697303000158 putative active site [active] 697303000159 putative NTP binding site [chemical binding]; other site 697303000160 putative nucleic acid binding site [nucleotide binding]; other site 697303000161 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697303000162 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 697303000163 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 697303000164 nucleoside/Zn binding site; other site 697303000165 dimer interface [polypeptide binding]; other site 697303000166 catalytic motif [active] 697303000167 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303000168 dimerization interface [polypeptide binding]; other site 697303000169 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 697303000170 PAS domain S-box; Region: sensory_box; TIGR00229 697303000171 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303000172 putative active site [active] 697303000173 heme pocket [chemical binding]; other site 697303000174 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 697303000175 GAF domain; Region: GAF; cl00853 697303000176 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303000177 Zn2+ binding site [ion binding]; other site 697303000178 Mg2+ binding site [ion binding]; other site 697303000179 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 697303000180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303000181 Walker A motif; other site 697303000182 ATP binding site [chemical binding]; other site 697303000183 Walker B motif; other site 697303000184 arginine finger; other site 697303000185 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 697303000186 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 697303000187 recombination protein RecR; Reviewed; Region: recR; PRK00076 697303000188 RecR protein; Region: RecR; pfam02132 697303000189 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 697303000190 putative active site [active] 697303000191 putative metal-binding site [ion binding]; other site 697303000192 tetramer interface [polypeptide binding]; other site 697303000193 CrcB-like protein; Region: CRCB; cl09114 697303000194 CrcB-like protein; Region: CRCB; cl09114 697303000195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303000196 Zn2+ binding site [ion binding]; other site 697303000197 Mg2+ binding site [ion binding]; other site 697303000198 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303000199 Zn2+ binding site [ion binding]; other site 697303000200 Mg2+ binding site [ion binding]; other site 697303000201 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303000202 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 697303000203 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000204 NAD(P) binding site [chemical binding]; other site 697303000205 active site 697303000206 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697303000207 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303000208 RNA binding surface [nucleotide binding]; other site 697303000209 PseudoU_synth_RsuA: Pseudouridine synthase, Escherichia coli RsuA like. This group is comprised of eukaryotic and bacterial proteins similar to Escherichia coli RsuA. Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA...; Region: PseudoU_synth_RsuA; cd02553 697303000210 active site 697303000211 uracil binding [chemical binding]; other site 697303000212 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303000213 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303000214 DNA binding site [nucleotide binding] 697303000215 domain linker motif; other site 697303000216 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_1; cd06277 697303000217 putative dimerization interface [polypeptide binding]; other site 697303000218 putative ligand binding site [chemical binding]; other site 697303000219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303000220 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697303000221 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 697303000222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303000223 putative PBP binding loops; other site 697303000224 dimer interface [polypeptide binding]; other site 697303000225 ABC-ATPase subunit interface; other site 697303000226 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697303000227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303000228 dimer interface [polypeptide binding]; other site 697303000229 conserved gate region; other site 697303000230 ABC-ATPase subunit interface; other site 697303000231 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 697303000232 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; cl15381 697303000233 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 697303000234 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 697303000235 active site 697303000236 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 697303000237 active site 697303000238 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 697303000239 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 697303000240 active site 697303000241 Substrate binding site; other site 697303000242 Mg++ binding site; other site 697303000243 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 697303000244 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 697303000245 sulfate 1 binding site; other site 697303000246 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 697303000247 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697303000248 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 697303000249 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 697303000250 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 697303000251 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 697303000252 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 697303000253 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000254 NAD(P) binding site [chemical binding]; other site 697303000255 active site 697303000256 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697303000257 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000258 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 697303000259 Predicted membrane protein [Function unknown]; Region: COG1511 697303000260 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 697303000261 ABC-2 type transporter; Region: ABC2_membrane; cl11417 697303000262 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 697303000263 homodimer interface [polypeptide binding]; other site 697303000264 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 697303000265 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 697303000266 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 697303000267 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 697303000268 starch-binding site 2 [chemical binding]; other site 697303000269 starch-binding site 1 [chemical binding]; other site 697303000270 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 697303000271 S-layer homology domain; Region: SLH; pfam00395 697303000272 S-layer homology domain; Region: SLH; pfam00395 697303000273 S-layer homology domain; Region: SLH; pfam00395 697303000274 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 697303000275 Ligand Binding Site [chemical binding]; other site 697303000276 TIGR00269 family protein; Region: TIGR00269 697303000277 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 697303000278 Fumarase C-terminus; Region: Fumerase_C; cl00795 697303000279 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 697303000280 Fe-S cluster binding site [ion binding]; other site 697303000281 active site 697303000282 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 697303000283 CPxP motif; other site 697303000284 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000285 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303000286 dimerization interface [polypeptide binding]; other site 697303000287 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 697303000288 CPxP motif; other site 697303000289 YeeE/YedE family (DUF395); Region: DUF395; cl01018 697303000290 YeeE/YedE family (DUF395); Region: DUF395; cl01018 697303000291 DsrE/DsrF-like family; Region: DrsE; cl00672 697303000292 DsrE/DsrF-like family; Region: DrsE; cl00672 697303000293 DsrE/DsrF-like family; Region: DrsE; cl00672 697303000294 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 697303000295 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000296 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697303000297 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 697303000298 lipoyl attachment site [posttranslational modification]; other site 697303000299 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697303000300 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303000301 Methyladenine glycosylase; Region: Adenine_glyco; cl01059 697303000302 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 697303000303 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 697303000304 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 697303000305 homodimer interface [polypeptide binding]; other site 697303000306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303000307 catalytic residue [active] 697303000308 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 697303000309 thymidylate kinase; Validated; Region: tmk; PRK00698 697303000310 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 697303000311 TMP-binding site; other site 697303000312 ATP-binding site [chemical binding]; other site 697303000313 Nitrogen regulatory protein P-II; Region: P-II; cl00412 697303000314 Protein of unknown function (DUF327); Region: DUF327; cl00753 697303000315 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 697303000316 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303000317 PSP1 C-terminal conserved region; Region: PSP1; cl00770 697303000318 Protein of unknown function (DUF1634); Region: DUF1634; cl01741 697303000319 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 697303000320 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 697303000321 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303000322 Sulfatase; Region: Sulfatase; cl10460 697303000323 Amidinotransferase; Region: Amidinotransf; cl12043 697303000324 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 697303000325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303000326 S-adenosylmethionine binding site [chemical binding]; other site 697303000327 Predicted methyltransferases [General function prediction only]; Region: COG0313 697303000328 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 697303000329 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 697303000330 Cation efflux family; Region: Cation_efflux; cl00316 697303000331 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 697303000332 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 697303000333 Nucleoside recognition; Region: Gate; cl00486 697303000334 Nucleoside recognition; Region: Gate; cl00486 697303000335 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 697303000336 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 697303000337 active site 697303000338 NTP binding site [chemical binding]; other site 697303000339 metal binding triad [ion binding]; metal-binding site 697303000340 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 697303000341 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303000342 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 697303000343 active site 1 [active] 697303000344 dimer interface [polypeptide binding]; other site 697303000345 hexamer interface [polypeptide binding]; other site 697303000346 active site 2 [active] 697303000347 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 697303000348 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 697303000349 active site 697303000350 HIGH motif; other site 697303000351 KMSKS motif; other site 697303000352 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 697303000353 tRNA binding surface [nucleotide binding]; other site 697303000354 anticodon binding site; other site 697303000355 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 697303000356 dimer interface [polypeptide binding]; other site 697303000357 putative tRNA-binding site [nucleotide binding]; other site 697303000358 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 697303000359 active site 697303000360 Domain of unknown function (DUF348); Region: DUF348; pfam03990 697303000361 Domain of unknown function (DUF348); Region: DUF348; pfam03990 697303000362 G5 domain; Region: G5; pfam07501 697303000363 3D domain; Region: 3D; cl01439 697303000364 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303000365 S-adenosylmethionine binding site [chemical binding]; other site 697303000366 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cl00206 697303000367 S-layer homology domain; Region: SLH; pfam00395 697303000368 S-layer homology domain; Region: SLH; pfam00395 697303000369 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 697303000370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303000371 Domain of unknown function DUF59; Region: DUF59; cl00941 697303000372 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 697303000373 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 697303000374 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 697303000375 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303000376 Walker A motif; other site 697303000377 ATP binding site [chemical binding]; other site 697303000378 Walker B motif; other site 697303000379 arginine finger; other site 697303000380 Peptidase family M41; Region: Peptidase_M41; pfam01434 697303000381 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK08375 697303000382 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 697303000383 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 697303000384 NADH dehydrogenase; Region: NADHdh; cl00469 697303000385 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 697303000386 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 697303000387 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 697303000388 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 697303000389 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 697303000390 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; cl00418 697303000391 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 697303000392 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 697303000393 G1 box; other site 697303000394 GTP/Mg2+ binding site [chemical binding]; other site 697303000395 Switch I region; other site 697303000396 G2 box; other site 697303000397 Switch II region; other site 697303000398 G3 box; other site 697303000399 G4 box; other site 697303000400 G5 box; other site 697303000401 Acylphosphatase; Region: Acylphosphatase; cl00551 697303000402 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 697303000403 HypF finger; Region: zf-HYPF; pfam07503 697303000404 HypF finger; Region: zf-HYPF; pfam07503 697303000405 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 697303000406 HupF/HypC family; Region: HupF_HypC; cl00394 697303000407 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypD; COG0409 697303000408 Hydrogenase formation hypA family; Region: HypD; cl12072 697303000409 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 697303000410 dimerization interface [polypeptide binding]; other site 697303000411 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 697303000412 ATP binding site [chemical binding]; other site 697303000413 Response regulator receiver domain; Region: Response_reg; pfam00072 697303000414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303000415 active site 697303000416 phosphorylation site [posttranslational modification] 697303000417 intermolecular recognition site; other site 697303000418 dimerization interface [polypeptide binding]; other site 697303000419 hypothetical protein; Provisional; Region: PRK08185 697303000420 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697303000421 intersubunit interface [polypeptide binding]; other site 697303000422 active site 697303000423 zinc binding site [ion binding]; other site 697303000424 Na+ binding site [ion binding]; other site 697303000425 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 697303000426 transcription termination factor Rho; Provisional; Region: rho; PRK09376 697303000427 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 697303000428 RNA binding site [nucleotide binding]; other site 697303000429 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 697303000430 multimer interface [polypeptide binding]; other site 697303000431 Walker A motif; other site 697303000432 ATP binding site [chemical binding]; other site 697303000433 Walker B motif; other site 697303000434 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 697303000435 Thymidine kinase; Region: TK; cl00631 697303000436 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 697303000437 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 697303000438 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303000439 S-adenosylmethionine binding site [chemical binding]; other site 697303000440 peptide chain release factor 1; Validated; Region: prfA; PRK00591 697303000441 RF-1 domain; Region: RF-1; cl02875 697303000442 RF-1 domain; Region: RF-1; cl02875 697303000443 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 697303000444 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 697303000445 SUA5 domain; Region: SUA5; pfam03481 697303000446 Low molecular weight phosphatase family; Region: LMWPc; cd00115 697303000447 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 697303000448 active site 697303000449 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 697303000450 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303000451 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 697303000452 catalytic motif [active] 697303000453 Zn binding site [ion binding]; other site 697303000454 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 697303000455 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 697303000456 Mg++ binding site [ion binding]; other site 697303000457 putative catalytic motif [active] 697303000458 substrate binding site [chemical binding]; other site 697303000459 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 697303000460 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 697303000461 active site 697303000462 homodimer interface [polypeptide binding]; other site 697303000463 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 697303000464 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697303000465 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 697303000466 hinge; other site 697303000467 active site 697303000468 OPT oligopeptide transporter protein; Region: OPT; cl14607 697303000469 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 697303000470 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 697303000471 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 697303000472 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000473 NAD(P) binding pocket [chemical binding]; other site 697303000474 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 697303000475 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 697303000476 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 697303000477 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 697303000478 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 697303000479 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 697303000480 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 697303000481 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 697303000482 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 697303000483 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 697303000484 S-layer homology domain; Region: SLH; pfam00395 697303000485 S-layer homology domain; Region: SLH; pfam00395 697303000486 S-layer homology domain; Region: SLH; pfam00395 697303000487 S-layer homology domain; Region: SLH; pfam00395 697303000488 stage II sporulation protein D; Region: spore_II_D; TIGR02870 697303000489 Stage II sporulation protein; Region: SpoIID; pfam08486 697303000490 Peptidase family M23; Region: Peptidase_M23; pfam01551 697303000491 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000492 rod shape-determining protein Mbl; Provisional; Region: PRK13928 697303000493 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 697303000494 ATP binding site [chemical binding]; other site 697303000495 profilin binding site; other site 697303000496 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12818 697303000497 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 697303000498 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 697303000499 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 697303000500 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 697303000501 flagellar rod assembly protein/muramidase FlgJ; Provisional; Region: flgJ; PRK12712 697303000502 Rod binding protein; Region: Rod-binding; cl01626 697303000503 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 697303000504 integral membrane protein MviN; Region: mviN; TIGR01695 697303000505 MatE; Region: MatE; cl10513 697303000506 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 697303000507 Uncharacterized conserved protein [Function unknown]; Region: COG2006 697303000508 4Fe-4S binding domain; Region: Fer4; cl02805 697303000509 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 697303000510 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 697303000511 Phd_YefM; Region: PhdYeFM; cl09153 697303000512 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 697303000513 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 697303000514 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 697303000515 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303000516 Walker A motif; other site 697303000517 ATP binding site [chemical binding]; other site 697303000518 Walker B motif; other site 697303000519 arginine finger; other site 697303000520 PRD domain; Region: PRD; cl15445 697303000521 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303000522 active pocket/dimerization site; other site 697303000523 active site 697303000524 phosphorylation site [posttranslational modification] 697303000525 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697303000526 active site 697303000527 phosphorylation site [posttranslational modification] 697303000528 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697303000529 active site 697303000530 phosphorylation site [posttranslational modification] 697303000531 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 697303000532 intersubunit interface [polypeptide binding]; other site 697303000533 active site 697303000534 Zn2+ binding site [ion binding]; other site 697303000535 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 697303000536 L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235 697303000537 putative NAD(P) binding site [chemical binding]; other site 697303000538 catalytic Zn binding site [ion binding]; other site 697303000539 Entner-Doudoroff aldolase; Region: eda; TIGR01182 697303000540 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 697303000541 active site 697303000542 intersubunit interface [polypeptide binding]; other site 697303000543 catalytic residue [active] 697303000544 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 697303000545 P-loop; other site 697303000546 active site 697303000547 phosphorylation site [posttranslational modification] 697303000548 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 697303000549 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 697303000550 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 697303000551 classical (c) SDRs; Region: SDR_c; cd05233 697303000552 NAD(P) binding site [chemical binding]; other site 697303000553 active site 697303000554 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 697303000555 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000556 SAF domain; Region: SAF; cl00555 697303000557 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 697303000558 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 697303000559 galactonate dehydratase; Provisional; Region: PRK14017 697303000560 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 697303000561 putative active site pocket [active] 697303000562 putative metal binding site [ion binding]; other site 697303000563 Entner-Doudoroff aldolase; Region: eda; TIGR01182 697303000564 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 697303000565 active site 697303000566 intersubunit interface [polypeptide binding]; other site 697303000567 catalytic residue [active] 697303000568 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 697303000569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303000570 putative substrate translocation pore; other site 697303000571 Transposase domain (DUF772); Region: DUF772; cl12084 697303000572 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303000573 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 697303000574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303000575 Walker A motif; other site 697303000576 ATP binding site [chemical binding]; other site 697303000577 Walker B motif; other site 697303000578 arginine finger; other site 697303000579 Transcriptional antiterminator [Transcription]; Region: COG3933 697303000580 PRD domain; Region: PRD; cl15445 697303000581 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 697303000582 active pocket/dimerization site; other site 697303000583 active site 697303000584 phosphorylation site [posttranslational modification] 697303000585 PRD domain; Region: PRD; cl15445 697303000586 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 697303000587 active site 697303000588 phosphorylation site [posttranslational modification] 697303000589 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 697303000590 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 697303000591 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303000592 active pocket/dimerization site; other site 697303000593 active site 697303000594 phosphorylation site [posttranslational modification] 697303000595 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697303000596 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 697303000597 intersubunit interface [polypeptide binding]; other site 697303000598 active site 697303000599 zinc binding site [ion binding]; other site 697303000600 Na+ binding site [ion binding]; other site 697303000601 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 697303000602 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697303000603 putative substrate binding site [chemical binding]; other site 697303000604 putative ATP binding site [chemical binding]; other site 697303000605 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 697303000606 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 697303000607 dimer interface [polypeptide binding]; other site 697303000608 active site 697303000609 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 697303000610 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 697303000611 Cation transport protein; Region: TrkH; cl10514 697303000612 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 697303000613 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000614 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 697303000615 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 697303000616 L-rhamnose isomerase (RhaA); Region: RhaA; cl09945 697303000617 D-xylulose kinases, Escherichia coli xylulokinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 697303000618 N- and C-terminal domain interface [polypeptide binding]; other site 697303000619 D-xylulose kinase; Region: XylB; TIGR01312 697303000620 active site 697303000621 catalytic site [active] 697303000622 metal binding site [ion binding]; metal-binding site 697303000623 xylulose binding site [chemical binding]; other site 697303000624 putative ATP binding site [chemical binding]; other site 697303000625 homodimer interface [polypeptide binding]; other site 697303000626 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697303000627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303000628 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303000629 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 697303000630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303000631 dimer interface [polypeptide binding]; other site 697303000632 conserved gate region; other site 697303000633 putative PBP binding loops; other site 697303000634 ABC-ATPase subunit interface; other site 697303000635 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697303000636 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303000637 dimer interface [polypeptide binding]; other site 697303000638 conserved gate region; other site 697303000639 putative PBP binding loops; other site 697303000640 ABC-ATPase subunit interface; other site 697303000641 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 697303000642 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000643 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697303000644 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303000645 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303000646 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697303000647 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000648 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 697303000649 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 697303000650 Glycosyl hydrolase family 3 C terminal domain; Region: Glyco_hydro_3_C; pfam01915 697303000651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697303000652 Coenzyme A binding pocket [chemical binding]; other site 697303000653 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 697303000654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697303000655 Coenzyme A binding pocket [chemical binding]; other site 697303000656 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 697303000657 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 697303000658 active site 697303000659 dimer interface [polypeptide binding]; other site 697303000660 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 697303000661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000662 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000663 OPT oligopeptide transporter protein; Region: OPT; cl14607 697303000664 Uncharacterized conserved protein [Function unknown]; Region: COG3342 697303000665 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 697303000666 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 697303000667 hypothetical protein; Validated; Region: PRK07682 697303000668 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697303000669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303000670 homodimer interface [polypeptide binding]; other site 697303000671 catalytic residue [active] 697303000672 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000673 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 697303000674 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303000675 FeoA domain; Region: FeoA; cl00838 697303000676 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 697303000677 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 697303000678 G1 box; other site 697303000679 GTP/Mg2+ binding site [chemical binding]; other site 697303000680 Switch I region; other site 697303000681 G2 box; other site 697303000682 G3 box; other site 697303000683 Switch II region; other site 697303000684 G4 box; other site 697303000685 G5 box; other site 697303000686 Nucleoside recognition; Region: Gate; cl00486 697303000687 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 697303000688 Nucleoside recognition; Region: Gate; cl00486 697303000689 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697303000690 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 697303000691 Walker A/P-loop; other site 697303000692 ATP binding site [chemical binding]; other site 697303000693 Q-loop/lid; other site 697303000694 ABC transporter signature motif; other site 697303000695 Walker B; other site 697303000696 D-loop; other site 697303000697 H-loop/switch region; other site 697303000698 Cobalt transport protein; Region: CbiQ; cl00463 697303000699 cobalt transport protein CbiM; Provisional; Region: PRK07331 697303000700 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 697303000701 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 697303000702 nickel responsive regulator; Provisional; Region: PRK04460 697303000703 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 697303000704 subunit; Region: OAD_beta; cl00816 697303000705 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 697303000706 DNA polymerase IV; Provisional; Region: PRK14133 697303000707 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 697303000708 active site 697303000709 DNA binding site [nucleotide binding] 697303000710 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 697303000711 MatE; Region: MatE; cl10513 697303000712 MatE; Region: MatE; cl10513 697303000713 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 697303000714 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697303000715 E3 interaction surface; other site 697303000716 lipoyl attachment site [posttranslational modification]; other site 697303000717 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 697303000718 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697303000719 E3 interaction surface; other site 697303000720 lipoyl attachment site [posttranslational modification]; other site 697303000721 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697303000722 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 697303000723 Walker A/P-loop; other site 697303000724 ATP binding site [chemical binding]; other site 697303000725 Q-loop/lid; other site 697303000726 ABC transporter signature motif; other site 697303000727 Walker B; other site 697303000728 D-loop; other site 697303000729 H-loop/switch region; other site 697303000730 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 697303000731 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 697303000732 FtsX-like permease family; Region: FtsX; pfam02687 697303000733 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 697303000734 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 697303000735 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 697303000736 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 697303000737 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 697303000738 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 697303000739 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 697303000740 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303000741 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 697303000742 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; cl15476 697303000743 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 697303000744 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 697303000745 helicase-exonuclease AddAB, AddA subunit; Region: addA_Gpos; TIGR02785 697303000746 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303000747 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303000748 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 697303000749 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697303000750 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 697303000751 active site 697303000752 metal binding site [ion binding]; metal-binding site 697303000753 DNA binding site [nucleotide binding] 697303000754 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 697303000755 SbcCD and other Mre11/Rad50 (MR) complexes are implicated in the metabolism of DNA ends. They cleave ends sealed by hairpin structures and are thought to play a role in removing protein bound to DNA termini; Region: ABC_sbcCD; cd03279 697303000756 Walker A/P-loop; other site 697303000757 ATP binding site [chemical binding]; other site 697303000758 Q-loop/lid; other site 697303000759 ABC transporter signature motif; other site 697303000760 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 697303000761 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303000762 Q-loop/lid; other site 697303000763 ABC transporter signature motif; other site 697303000764 Walker B; other site 697303000765 D-loop; other site 697303000766 H-loop/switch region; other site 697303000767 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 697303000768 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 697303000769 tetramer interface [polypeptide binding]; other site 697303000770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303000771 catalytic residue [active] 697303000772 putative peroxiredoxin; Provisional; Region: PRK13599 697303000773 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 697303000774 dimer interface [polypeptide binding]; other site 697303000775 decamer (pentamer of dimers) interface [polypeptide binding]; other site 697303000776 catalytic triad [active] 697303000777 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697303000778 metal binding site 2 [ion binding]; metal-binding site 697303000779 putative DNA binding helix; other site 697303000780 metal binding site 1 [ion binding]; metal-binding site 697303000781 dimer interface [polypeptide binding]; other site 697303000782 structural Zn2+ binding site [ion binding]; other site 697303000783 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303000784 ADP-glucose phosphorylase; Region: PLN02643 697303000785 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 697303000786 dimer interface [polypeptide binding]; other site 697303000787 active site 697303000788 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; cl01286 697303000789 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 697303000790 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697303000791 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 697303000792 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 697303000793 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 697303000794 Flagellar FliJ protein; Region: FliJ; cl09161 697303000795 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 697303000796 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 697303000797 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 697303000798 NAD binding site [chemical binding]; other site 697303000799 dimer interface [polypeptide binding]; other site 697303000800 substrate binding site [chemical binding]; other site 697303000801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697303000802 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 697303000803 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 697303000804 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000805 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 697303000806 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000807 Domain of unknown function (DUF296); Region: DUF296; cl00720 697303000808 Inorganic pyrophosphatase [Energy production and conversion]; Region: OVP1; cl11452 697303000809 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 697303000810 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 697303000811 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 697303000812 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 697303000813 ligand binding site [chemical binding]; other site 697303000814 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697303000815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303000816 dimerization interface [polypeptide binding]; other site 697303000817 Histidine kinase; Region: His_kinase; pfam06580 697303000818 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303000819 ATP binding site [chemical binding]; other site 697303000820 Mg2+ binding site [ion binding]; other site 697303000821 G-X-G motif; other site 697303000822 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 697303000823 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303000824 active site 697303000825 phosphorylation site [posttranslational modification] 697303000826 intermolecular recognition site; other site 697303000827 dimerization interface [polypeptide binding]; other site 697303000828 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697303000829 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697303000830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697303000831 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 697303000832 putative ligand binding site [chemical binding]; other site 697303000833 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 697303000834 putative ligand binding site [chemical binding]; other site 697303000835 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 697303000836 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 697303000837 Walker A/P-loop; other site 697303000838 ATP binding site [chemical binding]; other site 697303000839 Q-loop/lid; other site 697303000840 ABC transporter signature motif; other site 697303000841 Walker B; other site 697303000842 D-loop; other site 697303000843 H-loop/switch region; other site 697303000844 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 697303000845 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 697303000846 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 697303000847 TM-ABC transporter signature motif; other site 697303000848 Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG1003 697303000849 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 697303000850 tetramer interface [polypeptide binding]; other site 697303000851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303000852 catalytic residue [active] 697303000853 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 697303000854 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 697303000855 tetramer interface [polypeptide binding]; other site 697303000856 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303000857 catalytic residue [active] 697303000858 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 697303000859 lipoyl attachment site [posttranslational modification]; other site 697303000860 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 697303000861 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 697303000862 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 697303000863 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 697303000864 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 697303000865 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 697303000866 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 697303000867 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697303000868 E3 interaction surface; other site 697303000869 lipoyl attachment site [posttranslational modification]; other site 697303000870 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 697303000871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000872 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697303000873 OsmC-like protein; Region: OsmC; cl00767 697303000874 hypothetical protein; Validated; Region: PRK07682 697303000875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697303000876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303000877 homodimer interface [polypeptide binding]; other site 697303000878 catalytic residue [active] 697303000879 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697303000880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000882 PRD domain; Region: PRD; cl15445 697303000883 PRD domain; Region: PRD; cl15445 697303000884 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697303000885 P-loop; other site 697303000886 active site 697303000887 phosphorylation site [posttranslational modification] 697303000888 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697303000889 active site 697303000890 phosphorylation site [posttranslational modification] 697303000891 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 697303000892 dimer interface [polypeptide binding]; other site 697303000893 active site 697303000894 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 697303000895 P-loop; other site 697303000896 active site 697303000897 phosphorylation site [posttranslational modification] 697303000898 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 697303000899 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 697303000900 TPP-binding site [chemical binding]; other site 697303000901 dimer interface [polypeptide binding]; other site 697303000902 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 697303000903 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697303000904 PYR/PP interface [polypeptide binding]; other site 697303000905 dimer interface [polypeptide binding]; other site 697303000906 TPP binding site [chemical binding]; other site 697303000907 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303000908 hypothetical protein; Provisional; Region: PRK08185 697303000909 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697303000910 intersubunit interface [polypeptide binding]; other site 697303000911 active site 697303000912 zinc binding site [ion binding]; other site 697303000913 Na+ binding site [ion binding]; other site 697303000914 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 697303000915 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 697303000916 active site 697303000917 ADP/pyrophosphate binding site [chemical binding]; other site 697303000918 dimerization interface [polypeptide binding]; other site 697303000919 allosteric effector site; other site 697303000920 fructose-1,6-bisphosphate binding site; other site 697303000921 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 697303000922 classical (c) SDRs; Region: SDR_c; cd05233 697303000923 NAD(P) binding site [chemical binding]; other site 697303000924 active site 697303000925 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 697303000926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303000927 DNA binding residues [nucleotide binding] 697303000928 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 697303000929 Glucitol operon activator protein (GutM); Region: GutM; cl01890 697303000930 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; cl01515 697303000931 Phosphotransferase system sorbitol-specific component IIBC [Carbohydrate transport and metabolism]; Region: SrlE; COG3732 697303000932 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 697303000933 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 697303000934 Transposase domain (DUF772); Region: DUF772; cl12084 697303000935 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303000936 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 697303000937 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 697303000938 active site 697303000939 intersubunit interactions; other site 697303000940 catalytic residue [active] 697303000941 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 697303000942 HPr interaction site; other site 697303000943 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697303000944 active site 697303000945 phosphorylation site [posttranslational modification] 697303000946 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 697303000947 substrate binding site [chemical binding]; other site 697303000948 Protein of unknown function (DUF521); Region: DUF521; pfam04412 697303000949 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 697303000950 substrate binding site [chemical binding]; other site 697303000951 ligand binding site [chemical binding]; other site 697303000952 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 697303000953 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 697303000954 phosphate binding site [ion binding]; other site 697303000955 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000956 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303000957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303000958 putative active site [active] 697303000959 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 697303000960 heme pocket [chemical binding]; other site 697303000961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303000962 Walker A motif; other site 697303000963 ATP binding site [chemical binding]; other site 697303000964 Walker B motif; other site 697303000965 arginine finger; other site 697303000966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000967 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303000968 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000969 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000970 PRD domain; Region: PRD; cl15445 697303000971 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 697303000972 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 697303000973 dimer interface [polypeptide binding]; other site 697303000974 active site 697303000975 metal binding site [ion binding]; metal-binding site 697303000976 Transglycosylase; Region: Transgly; cl07896 697303000977 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 697303000978 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 697303000979 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 697303000980 structural tetrad; other site 697303000981 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 697303000982 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 697303000983 metal binding site [ion binding]; metal-binding site 697303000984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303000985 dimerization interface [polypeptide binding]; other site 697303000986 putative DNA binding site [nucleotide binding]; other site 697303000987 putative Zn2+ binding site [ion binding]; other site 697303000988 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 697303000989 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 697303000990 4Fe-4S binding domain; Region: Fer4; cl02805 697303000991 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 697303000992 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321 697303000993 gating phenylalanine in ion channel; other site 697303000994 Membrane transport protein; Region: Mem_trans; cl09117 697303000995 bile acid transporter; Region: bass; TIGR00841 697303000996 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 697303000997 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697303000998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303000999 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 697303001000 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 697303001001 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 697303001002 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 697303001003 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303001004 Cation efflux family; Region: Cation_efflux; cl00316 697303001005 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 697303001006 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 697303001007 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 697303001008 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 697303001009 Walker A/P-loop; other site 697303001010 ATP binding site [chemical binding]; other site 697303001011 Q-loop/lid; other site 697303001012 ABC transporter signature motif; other site 697303001013 Walker B; other site 697303001014 D-loop; other site 697303001015 H-loop/switch region; other site 697303001016 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 697303001017 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 697303001018 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 697303001019 HIGH motif; other site 697303001020 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697303001021 active site 697303001022 KMSKS motif; other site 697303001023 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 697303001024 tRNA binding surface [nucleotide binding]; other site 697303001025 AzlC protein; Region: AzlC; cl00570 697303001026 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 697303001027 putative kinase; Provisional; Region: PRK09954 697303001028 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303001029 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 697303001030 substrate binding site [chemical binding]; other site 697303001031 ATP binding site [chemical binding]; other site 697303001032 Indigoidine synthase A like protein; Region: Indigoidine_A; cl00983 697303001033 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 697303001034 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 697303001035 putative active site [active] 697303001036 putative NTP binding site [chemical binding]; other site 697303001037 putative nucleic acid binding site [nucleotide binding]; other site 697303001038 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697303001039 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830; cl07951 697303001040 Phosphate transporter family; Region: PHO4; cl00396 697303001041 Transposase domain (DUF772); Region: DUF772; cl12084 697303001042 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303001043 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 697303001044 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 697303001045 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303001046 Walker B motif; other site 697303001047 arginine finger; other site 697303001048 PRD domain; Region: PRD; cl15445 697303001049 Transcriptional antiterminator [Transcription]; Region: COG3933 697303001050 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303001051 active pocket/dimerization site; other site 697303001052 active site 697303001053 phosphorylation site [posttranslational modification] 697303001054 PRD domain; Region: PRD; cl15445 697303001055 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 697303001056 active site 697303001057 P-loop; other site 697303001058 phosphorylation site [posttranslational modification] 697303001059 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 697303001060 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 697303001061 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 697303001062 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl11406 697303001063 NAD(P) binding site [chemical binding]; other site 697303001064 LDH/MDH dimer interface [polypeptide binding]; other site 697303001065 substrate binding site [chemical binding]; other site 697303001066 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 697303001067 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 697303001068 dimer interface [polypeptide binding]; other site 697303001069 active site 697303001070 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 697303001071 dimer interface [polypeptide binding]; other site 697303001072 active site 697303001073 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 697303001074 dihydrodipicolinate synthase; Region: dapA; TIGR00674 697303001075 dimer interface [polypeptide binding]; other site 697303001076 active site 697303001077 catalytic residue [active] 697303001078 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 697303001079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001080 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 697303001081 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 697303001082 active site 697303001083 methionine cluster; other site 697303001084 phosphorylation site [posttranslational modification] 697303001085 metal binding site [ion binding]; metal-binding site 697303001086 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 697303001087 4Fe-4S binding domain; Region: Fer4; cl02805 697303001088 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 697303001089 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 697303001090 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 697303001091 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 697303001092 Integrase core domain; Region: rve; cl01316 697303001093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303001094 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697303001095 Walker A motif; other site 697303001096 ATP binding site [chemical binding]; other site 697303001097 Walker B motif; other site 697303001098 Ubiquitin-like proteins; Region: UBQ; cl00155 697303001099 charged pocket; other site 697303001100 hydrophobic patch; other site 697303001101 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 697303001102 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 697303001103 ATP binding site [chemical binding]; other site 697303001104 substrate interface [chemical binding]; other site 697303001105 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 697303001106 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 697303001107 Walker A motif; other site 697303001108 Putative Fe-S cluster; Region: FeS; pfam04060 697303001109 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 697303001110 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303001111 dimer interface [polypeptide binding]; other site 697303001112 conserved gate region; other site 697303001113 putative PBP binding loops; other site 697303001114 ABC-ATPase subunit interface; other site 697303001115 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 697303001116 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 697303001117 Walker A/P-loop; other site 697303001118 ATP binding site [chemical binding]; other site 697303001119 Q-loop/lid; other site 697303001120 ABC transporter signature motif; other site 697303001121 Walker B; other site 697303001122 D-loop; other site 697303001123 H-loop/switch region; other site 697303001124 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 697303001125 MPT binding site; other site 697303001126 trimer interface [polypeptide binding]; other site 697303001127 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 697303001128 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 697303001129 dimer interface [polypeptide binding]; other site 697303001130 putative functional site; other site 697303001131 putative MPT binding site; other site 697303001132 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 697303001133 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 697303001134 dimer interface [polypeptide binding]; other site 697303001135 putative functional site; other site 697303001136 putative MPT binding site; other site 697303001137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303001138 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 697303001139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303001140 FeS/SAM binding site; other site 697303001141 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 697303001142 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 697303001143 trimer interface [polypeptide binding]; other site 697303001144 dimer interface [polypeptide binding]; other site 697303001145 putative active site [active] 697303001146 MOSC domain; Region: MOSC; pfam03473 697303001147 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 697303001148 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 697303001149 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 697303001150 active site 697303001151 P-loop; other site 697303001152 phosphorylation site [posttranslational modification] 697303001153 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697303001154 PRD domain; Region: PRD; cl15445 697303001155 PRD domain; Region: PRD; cl15445 697303001156 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697303001157 P-loop; other site 697303001158 active site 697303001159 phosphorylation site [posttranslational modification] 697303001160 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 697303001161 active site 697303001162 phosphorylation site [posttranslational modification] 697303001163 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697303001164 active site 697303001165 phosphorylation site [posttranslational modification] 697303001166 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 697303001167 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 697303001168 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 697303001169 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 697303001170 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 697303001171 active site 697303001172 metal binding site [ion binding]; metal-binding site 697303001173 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 697303001174 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 697303001175 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 697303001176 active site 697303001177 metal binding site [ion binding]; metal-binding site 697303001178 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 697303001179 Bacterial SH3 domain; Region: SH3_3; cl02551 697303001180 Bacterial SH3 domain; Region: SH3_3; cl02551 697303001181 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 697303001182 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 697303001183 FMN binding site [chemical binding]; other site 697303001184 active site 697303001185 catalytic residues [active] 697303001186 substrate binding site [chemical binding]; other site 697303001187 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 697303001188 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 697303001189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303001190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303001191 DNA binding site [nucleotide binding] 697303001192 domain linker motif; other site 697303001193 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697303001194 dimerization interface [polypeptide binding]; other site 697303001195 ligand binding site [chemical binding]; other site 697303001196 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697303001197 ligand binding site [chemical binding]; other site 697303001198 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 697303001199 substrate binding site [chemical binding]; other site 697303001200 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 697303001201 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 697303001202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303001203 dimer interface [polypeptide binding]; other site 697303001204 conserved gate region; other site 697303001205 putative PBP binding loops; other site 697303001206 ABC-ATPase subunit interface; other site 697303001207 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 697303001208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303001209 dimer interface [polypeptide binding]; other site 697303001210 conserved gate region; other site 697303001211 putative PBP binding loops; other site 697303001212 ABC-ATPase subunit interface; other site 697303001213 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 697303001214 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 697303001215 Walker A/P-loop; other site 697303001216 ATP binding site [chemical binding]; other site 697303001217 Q-loop/lid; other site 697303001218 ABC transporter signature motif; other site 697303001219 Walker B; other site 697303001220 D-loop; other site 697303001221 H-loop/switch region; other site 697303001222 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697303001223 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 697303001224 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 697303001225 Walker A/P-loop; other site 697303001226 ATP binding site [chemical binding]; other site 697303001227 Q-loop/lid; other site 697303001228 ABC transporter signature motif; other site 697303001229 Walker B; other site 697303001230 D-loop; other site 697303001231 H-loop/switch region; other site 697303001232 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697303001233 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 697303001234 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 697303001235 domain; Region: Glyco_hydro_2; pfam00703 697303001236 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 697303001237 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697303001238 ABC-ATPase subunit interface; other site 697303001239 dimer interface [polypeptide binding]; other site 697303001240 putative PBP binding regions; other site 697303001241 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 697303001242 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of...; Region: ABC_Metallic_Cations; cd03235 697303001243 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 697303001244 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 697303001245 metal binding site [ion binding]; metal-binding site 697303001246 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697303001247 metal binding site 2 [ion binding]; metal-binding site 697303001248 putative DNA binding helix; other site 697303001249 metal binding site 1 [ion binding]; metal-binding site 697303001250 dimer interface [polypeptide binding]; other site 697303001251 structural Zn2+ binding site [ion binding]; other site 697303001252 MoxR-like ATPases [General function prediction only]; Region: COG0714 697303001253 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303001254 Walker A motif; other site 697303001255 ATP binding site [chemical binding]; other site 697303001256 Walker B motif; other site 697303001257 arginine finger; other site 697303001258 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 697303001259 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 697303001260 LemA family; Region: LemA; cl00742 697303001261 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 697303001262 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303001263 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 697303001264 putative dimerization interface [polypeptide binding]; other site 697303001265 anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055 697303001266 anaerobic sulfite reductase subunit B; Provisional; Region: PRK08221 697303001267 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 697303001268 FAD binding pocket [chemical binding]; other site 697303001269 FAD binding motif [chemical binding]; other site 697303001270 phosphate binding motif [ion binding]; other site 697303001271 beta-alpha-beta structure motif; other site 697303001272 NAD binding pocket [chemical binding]; other site 697303001273 Iron coordination center [ion binding]; other site 697303001274 sulfite reductase, subunit C; Region: sulfite_red_C; TIGR02912 697303001275 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 697303001276 4Fe-4S binding domain; Region: Fer4; cl02805 697303001277 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 697303001278 active site 697303001279 Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007 697303001280 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 697303001281 Aminotransferase class-V; Region: Aminotran_5; pfam00266 697303001282 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303001283 catalytic residue [active] 697303001284 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 697303001285 trimerization site [polypeptide binding]; other site 697303001286 active site 697303001287 Domain of unknown function (DUF477); Region: DUF477; cl01535 697303001288 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 697303001289 putative active site [active] 697303001290 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 697303001291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303001292 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 697303001293 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 697303001294 putative binding site residues; other site 697303001295 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 697303001296 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697303001297 ABC-ATPase subunit interface; other site 697303001298 dimer interface [polypeptide binding]; other site 697303001299 putative PBP binding regions; other site 697303001300 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 697303001301 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697303001302 Walker A/P-loop; other site 697303001303 ATP binding site [chemical binding]; other site 697303001304 Q-loop/lid; other site 697303001305 ABC transporter signature motif; other site 697303001306 Walker B; other site 697303001307 D-loop; other site 697303001308 H-loop/switch region; other site 697303001309 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 697303001310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001311 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 697303001312 catalytic triad [active] 697303001313 cobyric acid synthase; Provisional; Region: PRK00784 697303001314 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001315 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001316 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 697303001317 catalytic triad [active] 697303001318 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 697303001319 AIR synthase related protein, N-terminal domain; Region: AIRS; pfam00586 697303001320 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 697303001321 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697303001322 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303001323 homodimer interface [polypeptide binding]; other site 697303001324 catalytic residue [active] 697303001325 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 697303001326 homotrimer interface [polypeptide binding]; other site 697303001327 Walker A motif; other site 697303001328 GTP binding site [chemical binding]; other site 697303001329 Walker B motif; other site 697303001330 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 697303001331 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 697303001332 putative active site [active] 697303001333 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 697303001334 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 697303001335 tRNA; other site 697303001336 putative tRNA binding site [nucleotide binding]; other site 697303001337 putative NADP binding site [chemical binding]; other site 697303001338 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 697303001339 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 697303001340 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl03189 697303001341 domain interfaces; other site 697303001342 active site 697303001343 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 697303001344 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 697303001345 active site 697303001346 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 697303001347 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 697303001348 dimer interface [polypeptide binding]; other site 697303001349 active site 697303001350 Schiff base residues; other site 697303001351 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001352 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 697303001353 putative active site [active] 697303001354 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 697303001355 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 697303001356 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697303001357 inhibitor-cofactor binding pocket; inhibition site 697303001358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303001359 catalytic residue [active] 697303001360 Transposase domain (DUF772); Region: DUF772; cl12084 697303001361 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303001362 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 697303001363 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 697303001364 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 697303001365 dimer interface [polypeptide binding]; other site 697303001366 active site residues [active] 697303001367 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 697303001368 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 697303001369 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697303001370 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 697303001371 Walker A/P-loop; other site 697303001372 ATP binding site [chemical binding]; other site 697303001373 Q-loop/lid; other site 697303001374 ABC transporter signature motif; other site 697303001375 Walker B; other site 697303001376 D-loop; other site 697303001377 H-loop/switch region; other site 697303001378 Rhomboid family; Region: Rhomboid; cl11446 697303001379 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 697303001380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697303001381 DNA binding residues [nucleotide binding] 697303001382 dimerization interface [polypeptide binding]; other site 697303001383 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 697303001384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303001385 H+ Antiporter protein; Region: 2A0121; TIGR00900 697303001386 putative substrate translocation pore; other site 697303001387 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 697303001388 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697303001389 Coenzyme A binding pocket [chemical binding]; other site 697303001390 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 697303001391 Protein of unknown function (DUF429); Region: DUF429; cl12046 697303001392 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 697303001393 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303001394 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303001395 Membrane transport protein; Region: Mem_trans; cl09117 697303001396 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303001397 DNA-binding site [nucleotide binding]; DNA binding site 697303001398 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 697303001399 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 697303001400 oligomer interface [polypeptide binding]; other site 697303001401 active site 697303001402 metal binding site [ion binding]; metal-binding site 697303001403 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 697303001404 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 697303001405 oligomer interface [polypeptide binding]; other site 697303001406 active site 697303001407 metal binding site [ion binding]; metal-binding site 697303001408 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 697303001409 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 697303001410 oligomer interface [polypeptide binding]; other site 697303001411 active site 697303001412 metal binding site [ion binding]; metal-binding site 697303001413 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 697303001414 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 697303001415 putative active site [active] 697303001416 putative NTP binding site [chemical binding]; other site 697303001417 putative nucleic acid binding site [nucleotide binding]; other site 697303001418 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697303001419 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 697303001420 diiron binding motif [ion binding]; other site 697303001421 CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431 697303001422 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 697303001423 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 697303001424 dimer interface [polypeptide binding]; other site 697303001425 PYR/PP interface [polypeptide binding]; other site 697303001426 TPP binding site [chemical binding]; other site 697303001427 substrate binding site [chemical binding]; other site 697303001428 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 697303001429 Domain of unknown function; Region: EKR; cl11037 697303001430 4Fe-4S binding domain; Region: Fer4; cl02805 697303001431 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 697303001432 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 697303001433 TPP-binding site [chemical binding]; other site 697303001434 dimer interface [polypeptide binding]; other site 697303001435 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303001436 Zn2+ binding site [ion binding]; other site 697303001437 Mg2+ binding site [ion binding]; other site 697303001438 Cache domain; Region: Cache_2; cl07034 697303001439 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 697303001440 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303001441 dimerization interface [polypeptide binding]; other site 697303001442 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697303001443 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303001444 urocanate hydratase; Provisional; Region: PRK05414 697303001445 urocanate hydratase; Region: hutU; TIGR01228 697303001446 glutamate formiminotransferase; Region: FtcD; TIGR02024 697303001447 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 697303001448 Formiminotransferase domain; Region: FTCD; pfam02971 697303001449 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 697303001450 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 697303001451 active site 697303001452 Protein of unknown function DUF86; Region: DUF86; cl01031 697303001453 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697303001454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303001455 dimer interface [polypeptide binding]; other site 697303001456 conserved gate region; other site 697303001457 putative PBP binding loops; other site 697303001458 ABC-ATPase subunit interface; other site 697303001459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303001460 dimer interface [polypeptide binding]; other site 697303001461 conserved gate region; other site 697303001462 putative PBP binding loops; other site 697303001463 ABC-ATPase subunit interface; other site 697303001464 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697303001465 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303001466 Cache domain; Region: Cache_1; pfam02743 697303001467 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303001468 dimerization interface [polypeptide binding]; other site 697303001469 Histidine kinase; Region: His_kinase; pfam06580 697303001470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 697303001471 Response regulator receiver domain; Region: Response_reg; pfam00072 697303001472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303001473 active site 697303001474 phosphorylation site [posttranslational modification] 697303001475 intermolecular recognition site; other site 697303001476 dimerization interface [polypeptide binding]; other site 697303001477 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697303001478 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697303001479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697303001480 Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350 697303001481 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 697303001482 ligand binding site [chemical binding]; other site 697303001483 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 697303001484 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 697303001485 Walker A/P-loop; other site 697303001486 ATP binding site [chemical binding]; other site 697303001487 Q-loop/lid; other site 697303001488 ABC transporter signature motif; other site 697303001489 Walker B; other site 697303001490 D-loop; other site 697303001491 H-loop/switch region; other site 697303001492 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 697303001493 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 697303001494 TM-ABC transporter signature motif; other site 697303001495 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 697303001496 TM-ABC transporter signature motif; other site 697303001497 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697303001498 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303001499 DNA-binding site [nucleotide binding]; DNA binding site 697303001500 UTRA domain; Region: UTRA; cl01230 697303001501 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 697303001502 active site 697303001503 catalytic motif [active] 697303001504 Zn binding site [ion binding]; other site 697303001505 Sulfatase; Region: Sulfatase; cl10460 697303001506 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 697303001507 pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644 697303001508 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 697303001509 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 697303001510 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 697303001511 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303001512 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 697303001513 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 697303001514 active site turn [active] 697303001515 phosphorylation site [posttranslational modification] 697303001516 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 697303001517 HPr interaction site; other site 697303001518 glycerol kinase (GK) interaction site [polypeptide binding]; other site 697303001519 active site 697303001520 phosphorylation site [posttranslational modification] 697303001521 CAT RNA binding domain; Region: CAT_RBD; cl03904 697303001522 transcriptional antiterminator BglG; Provisional; Region: PRK09772 697303001523 PRD domain; Region: PRD; cl15445 697303001524 PRD domain; Region: PRD; cl15445 697303001525 trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858 697303001526 Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939 697303001527 active site 697303001528 catalytic residues [active] 697303001529 metal binding site [ion binding]; metal-binding site 697303001530 aconitate hydratase; Validated; Region: PRK07229 697303001531 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 697303001532 substrate binding site [chemical binding]; other site 697303001533 ligand binding site [chemical binding]; other site 697303001534 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 697303001535 substrate binding site [chemical binding]; other site 697303001536 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 697303001537 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 697303001538 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 697303001539 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 697303001540 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 697303001541 tetramerization interface [polypeptide binding]; other site 697303001542 active site 697303001543 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 697303001544 Pantoate-beta-alanine ligase; Region: PanC; cd00560 697303001545 active site 697303001546 ATP-binding site [chemical binding]; other site 697303001547 pantoate-binding site; other site 697303001548 HXXH motif; other site 697303001549 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 697303001550 oligomerization interface [polypeptide binding]; other site 697303001551 active site 697303001552 metal binding site [ion binding]; metal-binding site 697303001553 Uncharacterized conserved protein [Function unknown]; Region: COG5495 697303001554 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001555 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 697303001556 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 697303001557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303001558 S-adenosylmethionine binding site [chemical binding]; other site 697303001559 Protein of unknown function (DUF421); Region: DUF421; cl00990 697303001560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303001561 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 697303001562 active site 697303001563 motif I; other site 697303001564 motif II; other site 697303001565 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303001566 catabolite control protein A; Region: ccpA; TIGR01481 697303001567 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303001568 DNA binding site [nucleotide binding] 697303001569 domain linker motif; other site 697303001570 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697303001571 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697303001572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303001573 active site 697303001574 phosphorylation site [posttranslational modification] 697303001575 intermolecular recognition site; other site 697303001576 dimerization interface [polypeptide binding]; other site 697303001577 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303001578 DNA binding site [nucleotide binding] 697303001579 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303001580 dimerization interface [polypeptide binding]; other site 697303001581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 697303001582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303001583 dimer interface [polypeptide binding]; other site 697303001584 phosphorylation site [posttranslational modification] 697303001585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303001586 ATP binding site [chemical binding]; other site 697303001587 Mg2+ binding site [ion binding]; other site 697303001588 G-X-G motif; other site 697303001589 Sporulation and spore germination; Region: Germane; cl11253 697303001590 Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648 697303001591 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 697303001592 Predicted periplasmic protein (DUF2233); Region: DUF2233; cl10481 697303001593 Rubrerythrin [Energy production and conversion]; Region: COG1592 697303001594 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 697303001595 binuclear metal center [ion binding]; other site 697303001596 Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729 697303001597 iron binding site [ion binding]; other site 697303001598 S-adenosylmethionine synthetase; Validated; Region: PRK05250 697303001599 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 697303001600 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 697303001601 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 697303001602 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 697303001603 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001604 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001605 comF family protein; Region: comF; TIGR00201 697303001606 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303001607 flagellar operon protein TIGR03826; Region: YvyF 697303001608 FlgN protein; Region: FlgN; cl09176 697303001609 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 697303001610 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 697303001611 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 697303001612 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 697303001613 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 697303001614 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 697303001615 FliW protein; Region: FliW; cl00740 697303001616 Global regulator protein family; Region: CsrA; cl00670 697303001617 flagellin; Provisional; Region: PRK12804 697303001618 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 697303001619 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 697303001620 Transposase domain (DUF772); Region: DUF772; cl12084 697303001621 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 697303001622 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303001623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303001624 Walker A motif; other site 697303001625 ATP binding site [chemical binding]; other site 697303001626 Walker B motif; other site 697303001627 arginine finger; other site 697303001628 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303001629 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697303001630 Walker A motif; other site 697303001631 ATP binding site [chemical binding]; other site 697303001632 Walker B motif; other site 697303001633 arginine finger; other site 697303001634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303001635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 697303001636 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697303001637 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697303001638 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 697303001639 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 697303001640 putative metal binding site; other site 697303001641 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697303001642 binding surface 697303001643 TPR motif; other site 697303001644 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 697303001645 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697303001646 binding surface 697303001647 TPR motif; other site 697303001648 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 697303001649 active site 697303001650 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 697303001651 dimer interface [polypeptide binding]; other site 697303001652 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 697303001653 Ligand Binding Site [chemical binding]; other site 697303001654 Molecular Tunnel; other site 697303001655 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 697303001656 FlaG protein; Region: FlaG; cl00591 697303001657 flagellar capping protein; Validated; Region: fliD; PRK07737 697303001658 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 697303001659 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 697303001660 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 697303001661 Flagellar protein FliS; Region: FliS; cl00654 697303001662 Cache domain; Region: Cache_1; pfam02743 697303001663 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303001664 dimerization interface [polypeptide binding]; other site 697303001665 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303001666 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 697303001667 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 697303001668 substrate binding pocket [chemical binding]; other site 697303001669 membrane-bound complex binding site; other site 697303001670 hinge residues; other site 697303001671 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 697303001672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303001673 dimer interface [polypeptide binding]; other site 697303001674 conserved gate region; other site 697303001675 putative PBP binding loops; other site 697303001676 ABC-ATPase subunit interface; other site 697303001677 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 697303001678 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP. HisP...; Region: ABC_HisP_GlnQ_permeases; cd03262 697303001679 Walker A/P-loop; other site 697303001680 ATP binding site [chemical binding]; other site 697303001681 Q-loop/lid; other site 697303001682 ABC transporter signature motif; other site 697303001683 Walker B; other site 697303001684 D-loop; other site 697303001685 H-loop/switch region; other site 697303001686 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site; Region: RaiA; cd00552 697303001687 30S subunit binding site; other site 697303001688 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 697303001689 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303001690 Zn2+ binding site [ion binding]; other site 697303001691 Mg2+ binding site [ion binding]; other site 697303001692 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 697303001693 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303001694 3H domain; Region: 3H; pfam02829 697303001695 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 697303001696 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001697 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 697303001698 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697303001699 nucleotide binding region [chemical binding]; other site 697303001700 peptide chain release factor 2; Validated; Region: prfB; PRK00578 697303001701 RF-1 domain; Region: RF-1; cl02875 697303001702 RF-1 domain; Region: RF-1; cl02875 697303001703 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 697303001704 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 697303001705 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 697303001706 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 697303001707 RNA binding site [nucleotide binding]; other site 697303001708 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303001709 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 697303001710 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 697303001711 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 697303001712 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 697303001713 active site 697303001714 Amidinotransferase; Region: Amidinotransf; cl12043 697303001715 ornithine carbamoyltransferase; Validated; Region: PRK02102 697303001716 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 697303001717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001718 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 697303001719 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 697303001720 putative substrate binding site [chemical binding]; other site 697303001721 nucleotide binding site [chemical binding]; other site 697303001722 nucleotide binding site [chemical binding]; other site 697303001723 homodimer interface [polypeptide binding]; other site 697303001724 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 697303001725 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 697303001726 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 697303001727 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 697303001728 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 697303001729 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697303001730 Coenzyme A binding pocket [chemical binding]; other site 697303001731 UGMP family protein; Validated; Region: PRK09604 697303001732 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 697303001733 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 697303001734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001735 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 697303001736 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 697303001737 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001738 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 697303001739 ABC transporter; Region: ABC_tran_2; pfam12848 697303001740 ABCF_EF-3 Elongation factor 3 (EF-3) is a cytosolic protein required by fungal ribosomes for in vitro protein synthesis and for in vivo growth. EF-3 stimulates the binding of the EF-1: GTP: aa-tRNA ternary complex to the ribosomal A site by facilitated...; Region: ABCF_EF-3; cd03221 697303001741 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 697303001742 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 697303001743 flagellar motor protein MotD; Reviewed; Region: PRK09038 697303001744 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 697303001745 ligand binding site [chemical binding]; other site 697303001746 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 697303001747 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 697303001748 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001749 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 697303001750 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 697303001751 substrate binding site [chemical binding]; other site 697303001752 oxyanion hole (OAH) forming residues; other site 697303001753 trimer interface [polypeptide binding]; other site 697303001754 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 697303001755 Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158 697303001756 FAD binding site [chemical binding]; other site 697303001757 homotetramer interface [polypeptide binding]; other site 697303001758 substrate binding pocket [chemical binding]; other site 697303001759 catalytic base [active] 697303001760 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 697303001761 Ligand binding site [chemical binding]; other site 697303001762 Electron transfer flavoprotein domain; Region: ETF; pfam01012 697303001763 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 697303001764 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 697303001765 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 697303001766 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 697303001767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303001768 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 697303001769 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 697303001770 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 697303001771 active site 697303001772 (T/H)XGH motif; other site 697303001773 putative acyltransferase; Provisional; Region: PRK05790 697303001774 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 697303001775 dimer interface [polypeptide binding]; other site 697303001776 active site 697303001777 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303001778 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 697303001779 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 697303001780 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303001781 Walker A motif; other site 697303001782 ATP binding site [chemical binding]; other site 697303001783 Walker B motif; other site 697303001784 arginine finger; other site 697303001785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303001786 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 697303001787 dimer interaction site [polypeptide binding]; other site 697303001788 substrate-binding tunnel; other site 697303001789 active site 697303001790 catalytic site [active] 697303001791 substrate binding site [chemical binding]; other site 697303001792 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 697303001793 TM-ABC transporter signature motif; other site 697303001794 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 697303001795 TM-ABC transporter signature motif; other site 697303001796 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 697303001797 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 697303001798 Walker A/P-loop; other site 697303001799 ATP binding site [chemical binding]; other site 697303001800 Q-loop/lid; other site 697303001801 ABC transporter signature motif; other site 697303001802 Walker B; other site 697303001803 D-loop; other site 697303001804 H-loop/switch region; other site 697303001805 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 697303001806 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 697303001807 Walker A/P-loop; other site 697303001808 ATP binding site [chemical binding]; other site 697303001809 Q-loop/lid; other site 697303001810 ABC transporter signature motif; other site 697303001811 Walker B; other site 697303001812 D-loop; other site 697303001813 H-loop/switch region; other site 697303001814 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 697303001815 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697303001816 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 697303001817 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 697303001818 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303001819 hypothetical protein; Validated; Region: PRK06840 697303001820 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 697303001821 active site 697303001822 butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948 697303001823 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 697303001824 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 697303001825 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303001826 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 697303001827 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303001828 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303001829 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 697303001830 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 697303001831 dimer interface [polypeptide binding]; other site 697303001832 active site 697303001833 CoA binding pocket [chemical binding]; other site 697303001834 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303001835 Acetokinase family; Region: Acetate_kinase; cl01029 697303001836 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 697303001837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303001838 active site 697303001839 phosphorylation site [posttranslational modification] 697303001840 intermolecular recognition site; other site 697303001841 dimerization interface [polypeptide binding]; other site 697303001842 LytTr DNA-binding domain; Region: LytTR; cl04498 697303001843 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 697303001844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303001845 ATP binding site [chemical binding]; other site 697303001846 Mg2+ binding site [ion binding]; other site 697303001847 G-X-G motif; other site 697303001848 Accessory gene regulator B; Region: AgrB; cl01873 697303001849 Protein of unknown function (DUF322); Region: DUF322; cl00574 697303001850 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 697303001851 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 697303001852 FAD binding pocket [chemical binding]; other site 697303001853 FAD binding motif [chemical binding]; other site 697303001854 phosphate binding motif [ion binding]; other site 697303001855 beta-alpha-beta structure motif; other site 697303001856 NAD binding pocket [chemical binding]; other site 697303001857 Iron coordination center [ion binding]; other site 697303001858 putative oxidoreductase; Provisional; Region: PRK12831 697303001859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303001861 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 697303001862 8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588 697303001863 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 697303001864 minor groove reading motif; other site 697303001865 helix-hairpin-helix signature motif; other site 697303001866 substrate binding pocket [chemical binding]; other site 697303001867 active site 697303001868 Protein of unknown function (DUF554); Region: DUF554; cl00784 697303001869 HutP; Region: HutP; cl07944 697303001870 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 697303001871 active site 697303001872 catalytic triad [active] 697303001873 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303001874 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303001875 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303001876 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001877 Transposase domain (DUF772); Region: DUF772; cl12084 697303001878 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303001879 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 697303001880 oligomerisation interface [polypeptide binding]; other site 697303001881 mobile loop; other site 697303001882 roof hairpin; other site 697303001883 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 697303001884 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 697303001885 ring oligomerisation interface [polypeptide binding]; other site 697303001886 ATP/Mg binding site [chemical binding]; other site 697303001887 stacking interactions; other site 697303001888 hinge regions; other site 697303001889 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 697303001890 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 697303001891 putative active site [active] 697303001892 putative NTP binding site [chemical binding]; other site 697303001893 putative nucleic acid binding site [nucleotide binding]; other site 697303001894 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697303001895 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 697303001896 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 697303001897 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 697303001898 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the guanine...; Region: IMPDH; cd00381 697303001899 active site 697303001900 GMP synthase; Reviewed; Region: guaA; PRK00074 697303001901 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 697303001902 AMP/PPi binding site [chemical binding]; other site 697303001903 candidate oxyanion hole; other site 697303001904 catalytic triad [active] 697303001905 potential glutamine specificity residues [chemical binding]; other site 697303001906 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 697303001907 ATP Binding subdomain [chemical binding]; other site 697303001908 Ligand Binding sites [chemical binding]; other site 697303001909 Dimerization subdomain; other site 697303001910 Permease family; Region: Xan_ur_permease; cl00967 697303001911 AIR carboxylase; Region: AIRC; cl00310 697303001912 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 697303001913 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 697303001914 ATP binding site [chemical binding]; other site 697303001915 active site 697303001916 substrate binding site [chemical binding]; other site 697303001917 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 697303001918 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 697303001919 putative active site [active] 697303001920 catalytic triad [active] 697303001921 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 697303001922 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 697303001923 dimerization interface [polypeptide binding]; other site 697303001924 ATP binding site [chemical binding]; other site 697303001925 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 697303001926 dimerization interface [polypeptide binding]; other site 697303001927 ATP binding site [chemical binding]; other site 697303001928 amidophosphoribosyltransferase; Provisional; Region: PRK05793 697303001929 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 697303001930 active site 697303001931 tetramer interface [polypeptide binding]; other site 697303001932 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303001933 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 697303001934 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 697303001935 dimerization interface [polypeptide binding]; other site 697303001936 putative ATP binding site [chemical binding]; other site 697303001937 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 697303001938 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 697303001939 active site 697303001940 substrate binding site [chemical binding]; other site 697303001941 cosubstrate binding site; other site 697303001942 catalytic site [active] 697303001943 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 697303001944 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 697303001945 purine monophosphate binding site [chemical binding]; other site 697303001946 dimer interface [polypeptide binding]; other site 697303001947 putative catalytic residues [active] 697303001948 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 697303001949 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 697303001950 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 697303001951 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 697303001952 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 697303001953 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 697303001954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303001955 S-adenosylmethionine binding site [chemical binding]; other site 697303001956 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 697303001957 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 697303001958 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 697303001959 metal binding site [ion binding]; metal-binding site 697303001960 dimer interface [polypeptide binding]; other site 697303001961 stage V sporulation protein B; Region: spore_V_B; TIGR02900 697303001962 MatE; Region: MatE; cl10513 697303001963 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 697303001964 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 697303001965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303001966 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303001967 PRD domain; Region: PRD; cl15445 697303001968 PRD domain; Region: PRD; cl15445 697303001969 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697303001970 P-loop; other site 697303001971 active site 697303001972 phosphorylation site [posttranslational modification] 697303001973 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 697303001974 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 697303001975 active site 697303001976 P-loop; other site 697303001977 phosphorylation site [posttranslational modification] 697303001978 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 697303001979 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 697303001980 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cl00166 697303001981 methionine cluster; other site 697303001982 active site 697303001983 phosphorylation site [posttranslational modification] 697303001984 metal binding site [ion binding]; metal-binding site 697303001985 Trp repressor protein; Region: Trp_repressor; cl01121 697303001986 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 697303001987 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303001988 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 697303001989 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 697303001990 nucleotide binding pocket [chemical binding]; other site 697303001991 K-X-D-G motif; other site 697303001992 catalytic site [active] 697303001993 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 697303001994 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 697303001995 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 697303001996 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 697303001997 Dimer interface [polypeptide binding]; other site 697303001998 BRCT sequence motif; other site 697303001999 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 697303002000 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 697303002001 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 697303002002 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 697303002003 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 697303002004 GatB domain; Region: GatB_Yqey; cl11497 697303002005 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 697303002006 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 697303002007 peptide binding site [polypeptide binding]; other site 697303002008 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 697303002009 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 697303002010 peptide binding site [polypeptide binding]; other site 697303002011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 697303002012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303002013 dimer interface [polypeptide binding]; other site 697303002014 conserved gate region; other site 697303002015 putative PBP binding loops; other site 697303002016 ABC-ATPase subunit interface; other site 697303002017 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 697303002018 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 697303002019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303002020 dimer interface [polypeptide binding]; other site 697303002021 conserved gate region; other site 697303002022 putative PBP binding loops; other site 697303002023 ABC-ATPase subunit interface; other site 697303002024 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 697303002025 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 697303002026 Walker A/P-loop; other site 697303002027 ATP binding site [chemical binding]; other site 697303002028 Q-loop/lid; other site 697303002029 ABC transporter signature motif; other site 697303002030 Walker B; other site 697303002031 D-loop; other site 697303002032 H-loop/switch region; other site 697303002033 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697303002034 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 697303002035 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 697303002036 Walker A/P-loop; other site 697303002037 ATP binding site [chemical binding]; other site 697303002038 Q-loop/lid; other site 697303002039 ABC transporter signature motif; other site 697303002040 Walker B; other site 697303002041 D-loop; other site 697303002042 H-loop/switch region; other site 697303002043 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697303002044 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303002045 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 697303002046 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697303002047 active site 697303002048 metal binding site [ion binding]; metal-binding site 697303002049 ribonuclease PH; Reviewed; Region: rph; PRK00173 697303002050 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 697303002051 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 697303002052 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 697303002053 active site 697303002054 dimerization interface [polypeptide binding]; other site 697303002055 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697303002056 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 697303002057 active site 697303002058 metal binding site [ion binding]; metal-binding site 697303002059 homotetramer interface [polypeptide binding]; other site 697303002060 Protein of unknown function (DUF342); Region: DUF342; pfam03961 697303002061 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 697303002062 PAS domain S-box; Region: sensory_box; TIGR00229 697303002063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303002064 putative active site [active] 697303002065 heme pocket [chemical binding]; other site 697303002066 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303002067 PAS fold; Region: PAS_3; pfam08447 697303002068 putative active site [active] 697303002069 heme pocket [chemical binding]; other site 697303002070 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303002071 metal binding site [ion binding]; metal-binding site 697303002072 active site 697303002073 I-site; other site 697303002074 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 697303002075 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 697303002076 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 697303002077 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 697303002078 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 697303002079 Nitrogen regulatory protein P-II; Region: P-II; cl00412 697303002080 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 697303002081 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 697303002082 catalytic triad [active] 697303002083 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 697303002084 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 697303002085 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 697303002086 putative active site [active] 697303002087 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 697303002088 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 697303002089 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 697303002090 active site 697303002091 FMN binding site [chemical binding]; other site 697303002092 substrate binding site [chemical binding]; other site 697303002093 3Fe-4S cluster binding site [ion binding]; other site 697303002094 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 697303002095 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 697303002096 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 697303002097 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002098 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous to...; Region: arch_gltB; cd00981 697303002099 putative subunit interface; other site 697303002100 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 697303002101 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 697303002102 putative active site [active] 697303002103 metal binding site [ion binding]; metal-binding site 697303002104 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 697303002105 dimer interface [polypeptide binding]; other site 697303002106 substrate binding site [chemical binding]; other site 697303002107 ATP binding site [chemical binding]; other site 697303002108 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 697303002109 thiamine phosphate binding site [chemical binding]; other site 697303002110 active site 697303002111 pyrophosphate binding site [ion binding]; other site 697303002112 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 697303002113 substrate binding site [chemical binding]; other site 697303002114 multimerization interface [polypeptide binding]; other site 697303002115 ATP binding site [chemical binding]; other site 697303002116 Thiamine-precursor transporter protein (ThiW); Region: ThiW; cl01952 697303002117 Sodium:solute symporter family; Region: SSF; cl00456 697303002118 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 697303002119 PhoU domain; Region: PhoU; pfam01895 697303002120 PhoU domain; Region: PhoU; pfam01895 697303002121 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 697303002122 Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; cl15379 697303002123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002124 NAD(P) binding pocket [chemical binding]; other site 697303002125 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 697303002126 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 697303002127 Walker A/P-loop; other site 697303002128 ATP binding site [chemical binding]; other site 697303002129 Q-loop/lid; other site 697303002130 ABC transporter signature motif; other site 697303002131 Walker B; other site 697303002132 D-loop; other site 697303002133 H-loop/switch region; other site 697303002134 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 697303002135 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E; Region: ABC_Mj1267_LivG_branched; cd03219 697303002136 Walker A/P-loop; other site 697303002137 ATP binding site [chemical binding]; other site 697303002138 Q-loop/lid; other site 697303002139 ABC transporter signature motif; other site 697303002140 Walker B; other site 697303002141 D-loop; other site 697303002142 H-loop/switch region; other site 697303002143 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 697303002144 TM-ABC transporter signature motif; other site 697303002145 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 697303002146 TM-ABC transporter signature motif; other site 697303002147 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 697303002148 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 697303002149 putative ligand binding site [chemical binding]; other site 697303002150 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303002151 trigger factor; Provisional; Region: tig; PRK01490 697303002152 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 697303002153 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 697303002154 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 697303002155 oligomer interface [polypeptide binding]; other site 697303002156 active site residues [active] 697303002157 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 697303002158 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 697303002159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303002160 Walker A motif; other site 697303002161 ATP binding site [chemical binding]; other site 697303002162 Walker B motif; other site 697303002163 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 697303002164 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 697303002165 Found in ATP-dependent protease La (LON); Region: LON; smart00464 697303002166 Found in ATP-dependent protease La (LON); Region: LON; smart00464 697303002167 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303002168 Walker A motif; other site 697303002169 ATP binding site [chemical binding]; other site 697303002170 Walker B motif; other site 697303002171 arginine finger; other site 697303002172 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 697303002173 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 697303002174 G1 box; other site 697303002175 GTP/Mg2+ binding site [chemical binding]; other site 697303002176 Switch I region; other site 697303002177 G2 box; other site 697303002178 G3 box; other site 697303002179 Switch II region; other site 697303002180 G4 box; other site 697303002181 G5 box; other site 697303002182 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 697303002183 ATP synthase A chain; Region: ATP-synt_A; cl00413 697303002184 ATP synthase subunit C; Region: ATP-synt_C; cl00466 697303002185 Plant ATP synthase F0; Region: YMF19; cl07975 697303002186 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl15360 697303002187 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 697303002188 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 697303002189 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 697303002190 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 697303002191 beta subunit interaction interface [polypeptide binding]; other site 697303002192 Walker A motif; other site 697303002193 ATP binding site [chemical binding]; other site 697303002194 Walker B motif; other site 697303002195 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 697303002196 ATP synthase; Region: ATP-synt; cl00365 697303002197 F0F1 ATP synthase subunit gamma; Provisional; Region: PRK13422 697303002198 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 697303002199 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 697303002200 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 697303002201 alpha subunit interaction interface [polypeptide binding]; other site 697303002202 Walker A motif; other site 697303002203 ATP binding site [chemical binding]; other site 697303002204 Walker B motif; other site 697303002205 inhibitor binding site; inhibition site 697303002206 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 697303002207 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446 697303002208 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 697303002209 EamA-like transporter family; Region: EamA; cl01037 697303002210 EamA-like transporter family; Region: EamA; cl01037 697303002211 NAD synthetase; Provisional; Region: PRK13981 697303002212 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 697303002213 multimer interface [polypeptide binding]; other site 697303002214 active site 697303002215 catalytic triad [active] 697303002216 protein interface 1 [polypeptide binding]; other site 697303002217 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 697303002218 homodimer interface [polypeptide binding]; other site 697303002219 NAD binding pocket [chemical binding]; other site 697303002220 ATP binding pocket [chemical binding]; other site 697303002221 Mg binding site [ion binding]; other site 697303002222 active-site loop [active] 697303002223 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 697303002224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303002225 dimer interface [polypeptide binding]; other site 697303002226 conserved gate region; other site 697303002227 putative PBP binding loops; other site 697303002228 ABC-ATPase subunit interface; other site 697303002229 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 697303002230 NrtD and SsuB are the ATP-binding subunits of the bacterial ABC-type nitrate and sulfonate transport systems, respectively. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars; Region: ABC_NrtD_SsuB_transporters; cd03293 697303002231 Walker A/P-loop; other site 697303002232 ATP binding site [chemical binding]; other site 697303002233 Q-loop/lid; other site 697303002234 ABC transporter signature motif; other site 697303002235 Walker B; other site 697303002236 D-loop; other site 697303002237 H-loop/switch region; other site 697303002238 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 697303002239 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 697303002240 O-Antigen ligase; Region: Wzy_C; cl04850 697303002241 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697303002242 binding surface 697303002243 TPR motif; other site 697303002244 Transposase IS200 like; Region: Y1_Tnp; cl00848 697303002245 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 697303002246 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 697303002247 Probable transposase; Region: OrfB_IS605; pfam01385 697303002248 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697303002249 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303002250 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303002251 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 697303002252 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 697303002253 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303002254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303002255 Walker A motif; other site 697303002256 ATP binding site [chemical binding]; other site 697303002257 Walker B motif; other site 697303002258 arginine finger; other site 697303002259 Integrase core domain; Region: rve; cl01316 697303002260 IS2 transposase TnpB; Reviewed; Region: PRK09409 697303002261 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 697303002262 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 697303002263 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 697303002264 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 697303002265 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 697303002266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002267 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 697303002268 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002270 NAD(P) binding site [chemical binding]; other site 697303002271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303002272 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 697303002273 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 697303002274 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 697303002275 Ligand binding site; other site 697303002276 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 697303002277 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 697303002278 Probable Catalytic site; other site 697303002279 metal-binding site 697303002280 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 697303002281 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; cl14891 697303002282 Transposase; Region: DDE_Tnp_ISL3; pfam01610 697303002283 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303002284 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 697303002285 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303002286 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 697303002287 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 697303002288 NAD binding site [chemical binding]; other site 697303002289 substrate binding site [chemical binding]; other site 697303002290 homodimer interface [polypeptide binding]; other site 697303002291 active site 697303002292 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 697303002293 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 697303002294 NAD binding site [chemical binding]; other site 697303002295 substrate binding site [chemical binding]; other site 697303002296 homodimer interface [polypeptide binding]; other site 697303002297 active site 697303002298 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 697303002299 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 697303002300 substrate binding site; other site 697303002301 tetramer interface; other site 697303002302 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 697303002303 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 697303002304 NADP binding site [chemical binding]; other site 697303002305 active site 697303002306 putative substrate binding site [chemical binding]; other site 697303002307 Cupin domain; Region: Cupin_2; cl09118 697303002308 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 697303002309 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 697303002310 Substrate binding site; other site 697303002311 Cupin domain; Region: Cupin_2; cl09118 697303002312 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 697303002313 SecA binding site; other site 697303002314 Preprotein binding site; other site 697303002315 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 697303002316 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 697303002317 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 697303002318 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303002319 Walker A/P-loop; other site 697303002320 ATP binding site [chemical binding]; other site 697303002321 ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic molecules. The...; Region: ABC_ATPase; cd00267 697303002322 ABC transporter signature motif; other site 697303002323 Walker B; other site 697303002324 D-loop; other site 697303002325 H-loop/switch region; other site 697303002326 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 697303002327 active site 697303002328 metal binding site [ion binding]; metal-binding site 697303002329 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303002330 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 697303002331 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 697303002332 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 697303002333 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 697303002334 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 697303002335 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 697303002336 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 697303002337 ligand binding site [chemical binding]; other site 697303002338 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 697303002339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697303002340 putative Mg++ binding site [ion binding]; other site 697303002341 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697303002342 nucleotide binding region [chemical binding]; other site 697303002343 ATP-binding site [chemical binding]; other site 697303002344 Nuclease-related domain; Region: NERD; pfam08378 697303002345 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 697303002346 Integrase core domain; Region: rve; cl01316 697303002347 IS2 transposase TnpB; Reviewed; Region: PRK09409 697303002348 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303002349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303002350 Walker A motif; other site 697303002351 ATP binding site [chemical binding]; other site 697303002352 Walker B motif; other site 697303002353 arginine finger; other site 697303002354 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 697303002355 putative active site [active] 697303002356 Peptidase family M48; Region: Peptidase_M48; cl12018 697303002357 LemA family; Region: LemA; cl00742 697303002358 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 697303002359 active site 697303002360 metal binding site [ion binding]; metal-binding site 697303002361 homotetramer interface [polypeptide binding]; other site 697303002362 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases) [Energy production and conversion]; Region: Tas; COG0667 697303002363 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697303002364 active site 697303002365 catalytic tetrad [active] 697303002366 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 697303002367 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 697303002368 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697303002369 catalytic residue [active] 697303002370 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cl12032 697303002371 hypothetical protein; Reviewed; Region: PRK09588 697303002372 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 697303002373 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 697303002374 active site 697303002375 NTP binding site [chemical binding]; other site 697303002376 metal binding triad [ion binding]; metal-binding site 697303002377 antibiotic binding site [chemical binding]; other site 697303002378 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 697303002379 YcfA-like protein; Region: YcfA; cl00752 697303002380 macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397 697303002381 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 697303002382 TIGR02677 family protein; Region: TIGR02677 697303002383 Protein of unknown function (DUF2397); Region: DUF2397; pfam09660 697303002384 Protein of unknown function (DUF2398); Region: DUF2398; cl09875 697303002385 TIGR02680 family protein; Region: TIGR02680 697303002386 TIGR02680 family protein; Region: TIGR02680 697303002387 Protein of unknown function N-terminus (DUF3323); Region: DUF3323; pfam11796 697303002388 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 697303002389 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 697303002390 active site 697303002391 NTP binding site [chemical binding]; other site 697303002392 metal binding triad [ion binding]; metal-binding site 697303002393 antibiotic binding site [chemical binding]; other site 697303002394 Protein of unknown function DUF86; Region: DUF86; cl01031 697303002395 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 697303002396 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303002397 Beta-Casp domain; Region: Beta-Casp; cl12567 697303002398 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 697303002399 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 697303002400 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 697303002401 active site 697303002402 multimer interface [polypeptide binding]; other site 697303002403 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 697303002404 predicted active site [active] 697303002405 catalytic triad [active] 697303002406 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 697303002407 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl01276 697303002408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303002409 lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820 697303002410 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303002411 FeS/SAM binding site; other site 697303002412 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 697303002413 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 697303002414 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 697303002415 Walker A/P-loop; other site 697303002416 ATP binding site [chemical binding]; other site 697303002417 Q-loop/lid; other site 697303002418 ABC transporter signature motif; other site 697303002419 Walker B; other site 697303002420 D-loop; other site 697303002421 H-loop/switch region; other site 697303002422 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 697303002423 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 697303002424 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 697303002425 B12 binding site [chemical binding]; other site 697303002426 cobalt ligand [ion binding]; other site 697303002427 Amino acid permease; Region: AA_permease; cl00524 697303002428 Transcription antiterminator [Transcription]; Region: NusG; COG0250 697303002429 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 697303002430 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 697303002431 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 697303002432 active site 697303002433 substrate binding site [chemical binding]; other site 697303002434 metal binding site [ion binding]; metal-binding site 697303002435 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 697303002436 active site 697303002437 tetramer interface; other site 697303002438 Chain length determinant protein; Region: Wzz; cl01623 697303002439 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 697303002440 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303002441 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 697303002442 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 697303002443 Uncharacterized membrane protein [Function unknown]; Region: COG3949 697303002444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 697303002445 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 697303002446 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 697303002447 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 697303002448 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697303002449 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303002450 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 697303002451 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 697303002452 active site 697303002453 multimer interface [polypeptide binding]; other site 697303002454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303002455 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697303002456 putative substrate translocation pore; other site 697303002457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303002458 putative substrate translocation pore; other site 697303002459 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 697303002460 Protein of unknown function (DUF458); Region: DUF458; cl00861 697303002461 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 697303002462 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002463 PAP2_like_3 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria and archaea, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_3; cd03393 697303002464 active site 697303002465 Yip1 domain; Region: Yip1; cl12048 697303002466 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 697303002467 Cache domain; Region: Cache_1; pfam02743 697303002468 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 697303002469 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697303002470 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303002471 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 697303002472 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 697303002473 Ligand Binding Site [chemical binding]; other site 697303002474 AIR carboxylase; Region: AIRC; cl00310 697303002475 Protein of unknown function DUF111; Region: DUF111; cl03398 697303002476 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697303002477 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303002478 dimerization interface [polypeptide binding]; other site 697303002479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303002480 dimer interface [polypeptide binding]; other site 697303002481 phosphorylation site [posttranslational modification] 697303002482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303002483 ATP binding site [chemical binding]; other site 697303002484 G-X-G motif; other site 697303002485 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697303002486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303002487 active site 697303002488 phosphorylation site [posttranslational modification] 697303002489 intermolecular recognition site; other site 697303002490 dimerization interface [polypeptide binding]; other site 697303002491 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303002492 DNA binding site [nucleotide binding] 697303002493 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 697303002494 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 697303002495 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 697303002496 Protein of unknown function (DUF2680); Region: DUF2680; pfam10925 697303002497 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 697303002498 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 697303002499 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 697303002500 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697303002501 active site 697303002502 HIGH motif; other site 697303002503 nucleotide binding site [chemical binding]; other site 697303002504 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 697303002505 active site 697303002506 KMSKS motif; other site 697303002507 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 697303002508 tRNA binding surface [nucleotide binding]; other site 697303002509 anticodon binding site; other site 697303002510 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 697303002511 putative acetyltransferase YhhY; Provisional; Region: PRK10140 697303002512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697303002513 Coenzyme A binding pocket [chemical binding]; other site 697303002514 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 697303002515 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303002516 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697303002517 Uncharacterized conserved protein [Function unknown]; Region: COG3391 697303002518 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 697303002519 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697303002520 iron-sulfur cluster binding protein, putative; Region: TIGR00276 697303002521 4Fe-4S binding domain; Region: Fer4; cl02805 697303002522 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303002523 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303002524 DNA binding site [nucleotide binding] 697303002525 domain linker motif; other site 697303002526 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697303002527 dimerization interface [polypeptide binding]; other site 697303002528 ligand binding site [chemical binding]; other site 697303002529 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 697303002530 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 697303002531 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 697303002532 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 697303002533 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697303002534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303002535 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 697303002536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303002537 dimer interface [polypeptide binding]; other site 697303002538 conserved gate region; other site 697303002539 putative PBP binding loops; other site 697303002540 ABC-ATPase subunit interface; other site 697303002541 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697303002542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303002543 dimer interface [polypeptide binding]; other site 697303002544 conserved gate region; other site 697303002545 putative PBP binding loops; other site 697303002546 ABC-ATPase subunit interface; other site 697303002547 beta-phosphoglucomutase; Region: bPGM; TIGR01990 697303002548 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303002549 motif II; other site 697303002550 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303002551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303002552 dimerization interface [polypeptide binding]; other site 697303002553 putative DNA binding site [nucleotide binding]; other site 697303002554 putative Zn2+ binding site [ion binding]; other site 697303002555 Integrase core domain; Region: rve; cl01316 697303002556 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303002557 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303002558 DNA binding site [nucleotide binding] 697303002559 domain linker motif; other site 697303002560 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697303002561 dimerization interface [polypeptide binding]; other site 697303002562 ligand binding site [chemical binding]; other site 697303002563 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303002564 dimer interface [polypeptide binding]; other site 697303002565 conserved gate region; other site 697303002566 putative PBP binding loops; other site 697303002567 ABC-ATPase subunit interface; other site 697303002568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303002569 dimer interface [polypeptide binding]; other site 697303002570 conserved gate region; other site 697303002571 putative PBP binding loops; other site 697303002572 ABC-ATPase subunit interface; other site 697303002573 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697303002574 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303002575 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303002576 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 697303002577 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 697303002578 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 697303002579 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 697303002580 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 697303002581 Peptidase S8 family domain, uncharacterized subfamily 1; Region: Peptidases_S8_1; cd07487 697303002582 active site 697303002583 catalytic triad [active] 697303002584 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 697303002585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303002586 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 697303002587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303002588 Walker A motif; other site 697303002589 ATP binding site [chemical binding]; other site 697303002590 Walker B motif; other site 697303002591 arginine finger; other site 697303002592 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303002593 putative peptidoglycan binding site; other site 697303002594 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 697303002595 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303002596 single-stranded DNA-binding protein; Provisional; Region: PRK05813 697303002597 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 697303002598 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 697303002599 dimer interface [polypeptide binding]; other site 697303002600 ssDNA binding site [nucleotide binding]; other site 697303002601 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697303002602 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 697303002603 homodimer interface [polypeptide binding]; other site 697303002604 Walker A motif; other site 697303002605 ATP binding site [chemical binding]; other site 697303002606 hydroxycobalamin binding site [chemical binding]; other site 697303002607 Walker B motif; other site 697303002608 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapD_N; pfam08503 697303002609 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 697303002610 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 697303002611 putative trimer interface [polypeptide binding]; other site 697303002612 putative CoA binding site [chemical binding]; other site 697303002613 dihydrodipicolinate reductase; Provisional; Region: PRK00048 697303002614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002615 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 697303002616 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 697303002617 dihydrodipicolinate synthase; Region: dapA; TIGR00674 697303002618 dimer interface [polypeptide binding]; other site 697303002619 active site 697303002620 catalytic residue [active] 697303002621 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 697303002622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002623 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 697303002624 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697303002625 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 697303002626 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 697303002627 Walker A/P-loop; other site 697303002628 ATP binding site [chemical binding]; other site 697303002629 Q-loop/lid; other site 697303002630 ABC transporter signature motif; other site 697303002631 Walker B; other site 697303002632 D-loop; other site 697303002633 H-loop/switch region; other site 697303002634 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 697303002635 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 697303002636 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303002637 Walker A/P-loop; other site 697303002638 ATP binding site [chemical binding]; other site 697303002639 Q-loop/lid; other site 697303002640 ABC transporter signature motif; other site 697303002641 Walker B; other site 697303002642 D-loop; other site 697303002643 H-loop/switch region; other site 697303002644 glutamine synthetase, type I; Region: GlnA; TIGR00653 697303002645 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 697303002646 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 697303002647 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 697303002648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303002649 active site 697303002650 phosphorylation site [posttranslational modification] 697303002651 intermolecular recognition site; other site 697303002652 dimerization interface [polypeptide binding]; other site 697303002653 ANTAR domain; Region: ANTAR; cl04297 697303002654 isoaspartyl dipeptidase; Provisional; Region: PRK10657 697303002655 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 697303002656 dimer interface [polypeptide binding]; other site 697303002657 active site 697303002658 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 697303002659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303002660 DNA-binding site [nucleotide binding]; DNA binding site 697303002661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697303002662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303002663 homodimer interface [polypeptide binding]; other site 697303002664 catalytic residue [active] 697303002665 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 697303002666 Peptidase family M23; Region: Peptidase_M23; pfam01551 697303002667 Uncharacterised protein family (UPF0180); Region: UPF0180; cl04214 697303002668 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 697303002669 active sites [active] 697303002670 tetramer interface [polypeptide binding]; other site 697303002671 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303002672 NlpC/P60 family; Region: NLPC_P60; cl11438 697303002673 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697303002674 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 697303002675 Walker A/P-loop; other site 697303002676 ATP binding site [chemical binding]; other site 697303002677 Q-loop/lid; other site 697303002678 ABC transporter signature motif; other site 697303002679 Walker B; other site 697303002680 D-loop; other site 697303002681 H-loop/switch region; other site 697303002682 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 697303002683 oligomer interface [polypeptide binding]; other site 697303002684 tandem repeat interface [polypeptide binding]; other site 697303002685 active site residues [active] 697303002686 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 697303002687 active site 697303002688 NTP binding site [chemical binding]; other site 697303002689 metal binding triad [ion binding]; metal-binding site 697303002690 antibiotic binding site [chemical binding]; other site 697303002691 Protein of unknown function DUF86; Region: DUF86; cl01031 697303002692 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; cl02316 697303002693 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl11420 697303002694 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 697303002695 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 697303002696 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 697303002697 Protein of unknown function (DUF436); Region: DUF436; cl01860 697303002698 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303002699 Transposase domain (DUF772); Region: DUF772; cl12084 697303002700 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303002701 S-layer homology domain; Region: SLH; pfam00395 697303002702 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 697303002703 active site 697303002704 Glyco_18 domain; Region: Glyco_18; smart00636 697303002705 PspC domain; Region: PspC; cl00864 697303002706 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 697303002707 Amino acid permease; Region: AA_permease; cl00524 697303002708 Carbon starvation protein CstA; Region: CstA; cl00856 697303002709 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 697303002710 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303002711 active site 697303002712 phosphorylation site [posttranslational modification] 697303002713 intermolecular recognition site; other site 697303002714 dimerization interface [polypeptide binding]; other site 697303002715 LytTr DNA-binding domain; Region: LytTR; cl04498 697303002716 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 697303002717 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 697303002718 GAF domain; Region: GAF; cl00853 697303002719 Histidine kinase; Region: His_kinase; pfam06580 697303002720 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 697303002721 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 697303002722 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303002723 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303002724 DNA binding residues [nucleotide binding] 697303002725 Anti-sigma-K factor rskA; Region: RskA; cl15366 697303002726 DNA polymerase I; Provisional; Region: PRK05755 697303002727 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 697303002728 active site 697303002729 metal binding site 1 [ion binding]; metal-binding site 697303002730 putative 5' ssDNA interaction site; other site 697303002731 metal binding site 3; metal-binding site 697303002732 metal binding site 2 [ion binding]; metal-binding site 697303002733 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 697303002734 putative DNA binding site [nucleotide binding]; other site 697303002735 putative metal binding site [ion binding]; other site 697303002736 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 697303002737 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 697303002738 active site 697303002739 DNA binding site [nucleotide binding] 697303002740 catalytic site [active] 697303002741 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 697303002742 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 697303002743 CoA-binding site [chemical binding]; other site 697303002744 ATP-binding [chemical binding]; other site 697303002745 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 697303002746 N-acetyl-D-glucosamine binding site [chemical binding]; other site 697303002747 catalytic residue [active] 697303002748 nicotinate phosphoribosyltransferase; Reviewed; Region: PRK08662 697303002749 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_B; cd01571 697303002750 active site 697303002751 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 697303002752 peptide binding site [polypeptide binding]; other site 697303002753 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 697303002754 dimer interface [polypeptide binding]; other site 697303002755 Bacterial SH3 domain; Region: SH3_3; cl02551 697303002756 Bacterial SH3 domain; Region: SH3_3; cl02551 697303002757 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 697303002758 NlpC/P60 family; Region: NLPC_P60; cl11438 697303002759 TypA (tyrosine phosphorylated protein A)/BipA subfamily. BipA is a protein belonging to the ribosome-binding family of GTPases and is widely distributed in bacteria and plants. BipA was originally described as a protein that is induced in Salmonella...; Region: TypA_BipA; cd01891 697303002760 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 697303002761 G1 box; other site 697303002762 putative GEF interaction site [polypeptide binding]; other site 697303002763 GTP/Mg2+ binding site [chemical binding]; other site 697303002764 Switch I region; other site 697303002765 G2 box; other site 697303002766 G3 box; other site 697303002767 Switch II region; other site 697303002768 G4 box; other site 697303002769 G5 box; other site 697303002770 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 697303002771 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 697303002772 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 697303002773 N-acetyl-D-glucosamine binding site [chemical binding]; other site 697303002774 catalytic residue [active] 697303002775 DRTGG domain; Region: DRTGG; cl12147 697303002776 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 697303002777 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 697303002778 4Fe-4S binding domain; Region: Fer4; cl02805 697303002779 4Fe-4S binding domain; Region: Fer4; cl02805 697303002780 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 697303002781 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein) [Energy production and conversion]; Region: CdhE; COG1456 697303002782 Putative Fe-S cluster; Region: FeS; pfam04060 697303002783 DRTGG domain; Region: DRTGG; cl12147 697303002784 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303002785 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 697303002786 putative dimer interface [polypeptide binding]; other site 697303002787 [2Fe-2S] cluster binding site [ion binding]; other site 697303002788 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303002789 ATP binding site [chemical binding]; other site 697303002790 Mg2+ binding site [ion binding]; other site 697303002791 G-X-G motif; other site 697303002792 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 697303002793 dimer interface [polypeptide binding]; other site 697303002794 [2Fe-2S] cluster binding site [ion binding]; other site 697303002795 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 697303002796 dimer interface [polypeptide binding]; other site 697303002797 [2Fe-2S] cluster binding site [ion binding]; other site 697303002798 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 697303002799 Respiratory-chain NADH dehydrogenase 51 Kd subunit; Region: Complex1_51K; pfam01512 697303002800 SLBB domain; Region: SLBB; pfam10531 697303002801 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; cl11211 697303002802 4Fe-4S binding domain; Region: Fer4; cl02805 697303002803 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 697303002804 4Fe-4S binding domain; Region: Fer4; cl02805 697303002805 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 697303002806 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 697303002807 catalytic loop [active] 697303002808 iron binding site [ion binding]; other site 697303002809 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; cl11210 697303002810 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 697303002811 4Fe-4S binding domain; Region: Fer4; cl02805 697303002812 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 697303002813 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 697303002814 Maf-like protein; Region: Maf; pfam02545 697303002815 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 697303002816 active site 697303002817 dimer interface [polypeptide binding]; other site 697303002818 hypothetical protein; Reviewed; Region: PRK00024 697303002819 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 697303002820 MPN+ (JAMM) motif; other site 697303002821 Zinc-binding site [ion binding]; other site 697303002822 rod shape-determining protein MreB; Provisional; Region: PRK13927 697303002823 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 697303002824 ATP binding site [chemical binding]; other site 697303002825 gelsolin binding site; other site 697303002826 profilin binding site; other site 697303002827 rod shape-determining protein MreC; Provisional; Region: PRK13922 697303002828 Protein of unknown function (DUF904); Region: DUF904; cl11531 697303002829 rod shape-determining protein MreC; Region: MreC; pfam04085 697303002830 rod shape-determining protein MreD; Region: MreD; cl01087 697303002831 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697303002832 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697303002833 penicillin-binding protein 1B; Region: PBP_1b; TIGR02071 697303002834 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 697303002835 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 697303002836 septum formation inhibitor; Reviewed; Region: minC; PRK00513 697303002837 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 697303002838 septum site-determining protein MinD; Region: minD_bact; TIGR01968 697303002839 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 697303002840 Switch I; other site 697303002841 Switch II; other site 697303002842 Septum formation topological specificity factor MinE; Region: MinE; cl00538 697303002843 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 697303002844 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 697303002845 active site 697303002846 dimer interfaces [polypeptide binding]; other site 697303002847 catalytic residues [active] 697303002848 Peptidase family M23; Region: Peptidase_M23; pfam01551 697303002849 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 697303002850 active site 697303002851 putative substrate binding region [chemical binding]; other site 697303002852 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 697303002853 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 697303002854 B12 binding site [chemical binding]; other site 697303002855 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303002856 FeS/SAM binding site; other site 697303002857 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 697303002858 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 697303002859 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 697303002860 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 697303002861 homodimer interface [polypeptide binding]; other site 697303002862 oligonucleotide binding site [chemical binding]; other site 697303002863 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 697303002864 QueT transporter; Region: QueT; cl01932 697303002865 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303002866 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 697303002867 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 697303002868 Protein of unknown function (DUF464); Region: DUF464; cl01080 697303002869 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 697303002870 GTPase CgtA; Reviewed; Region: obgE; PRK12297 697303002871 GTP1/OBG; Region: GTP1_OBG; pfam01018 697303002872 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 697303002873 G1 box; other site 697303002874 GTP/Mg2+ binding site [chemical binding]; other site 697303002875 Switch I region; other site 697303002876 G2 box; other site 697303002877 G3 box; other site 697303002878 Switch II region; other site 697303002879 G4 box; other site 697303002880 G5 box; other site 697303002881 Domain of unknown function (DUF1967); Region: DUF1967; cl07779 697303002882 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 697303002883 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 697303002884 active site 697303002885 (T/H)XGH motif; other site 697303002886 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303002887 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 697303002888 Domain of unknown function DUF143; Region: DUF143; cl00519 697303002889 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 697303002890 YheO-like PAS domain; Region: PAS_6; pfam08348 697303002891 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 697303002892 DNA-binding interface [nucleotide binding]; DNA binding site 697303002893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303002894 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 697303002895 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 697303002896 B12 binding site [chemical binding]; other site 697303002897 Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cl02025 697303002898 asparagine synthetase B; Provisional; Region: asnB; PRK09431 697303002899 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 697303002900 active site 697303002901 dimer interface [polypeptide binding]; other site 697303002902 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 697303002903 Ligand Binding Site [chemical binding]; other site 697303002904 Molecular Tunnel; other site 697303002905 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 697303002906 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 697303002907 SLBB domain; Region: SLBB; pfam10531 697303002908 comEA protein; Region: comE; TIGR01259 697303002909 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 697303002910 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 697303002911 tetramer interfaces [polypeptide binding]; other site 697303002912 binuclear metal-binding site [ion binding]; other site 697303002913 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 697303002914 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697303002915 active site 697303002916 HIGH motif; other site 697303002917 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697303002918 active site 697303002919 KMSKS motif; other site 697303002920 benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224 697303002921 4Fe-4S binding domain; Region: Fer4; cl02805 697303002922 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 697303002923 homodimer interface [polypeptide binding]; other site 697303002924 substrate-cofactor binding pocket; other site 697303002925 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303002926 Aminotransferase class IV; Region: Aminotran_4; pfam01063 697303002927 catalytic residue [active] 697303002928 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 697303002929 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 697303002930 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 697303002931 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 697303002932 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 697303002933 Transposase domain (DUF772); Region: DUF772; cl12084 697303002934 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303002935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303002936 motif II; other site 697303002937 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303002938 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 697303002939 Competence protein; Region: Competence; cl00471 697303002940 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303002941 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 697303002942 DNA polymerase III, delta subunit; Region: holA; TIGR01128 697303002943 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 697303002944 Membrane protein of unknown function; Region: DUF360; cl00850 697303002945 Germination protease; Region: Peptidase_A25; cl04057 697303002946 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 697303002947 stage II sporulation protein P; Region: spore_II_P; TIGR02867 697303002948 Sulfatase; Region: Sulfatase; cl10460 697303002949 Sugar transport protein; Region: Sugar_transport; pfam06800 697303002950 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 697303002951 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 697303002952 GTP-binding protein LepA; Provisional; Region: PRK05433 697303002953 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 697303002954 G1 box; other site 697303002955 putative GEF interaction site [polypeptide binding]; other site 697303002956 GTP/Mg2+ binding site [chemical binding]; other site 697303002957 Switch I region; other site 697303002958 G2 box; other site 697303002959 G3 box; other site 697303002960 Switch II region; other site 697303002961 G4 box; other site 697303002962 G5 box; other site 697303002963 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 697303002964 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 697303002965 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 697303002966 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 697303002967 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303002968 FeS/SAM binding site; other site 697303002969 HemN C-terminal region; Region: HemN_C; pfam06969 697303002970 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 697303002971 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303002972 HrcA protein C terminal domain; Region: HrcA; pfam01628 697303002973 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 697303002974 dimer interface [polypeptide binding]; other site 697303002975 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 697303002976 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 697303002977 chaperone protein DnaJ; Provisional; Region: PRK14277 697303002978 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 697303002979 HSP70 interaction site [polypeptide binding]; other site 697303002980 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 697303002981 substrate binding site [polypeptide binding]; other site 697303002982 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 697303002983 Zn binding sites [ion binding]; other site 697303002984 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 697303002985 dimer interface [polypeptide binding]; other site 697303002986 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 697303002987 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303002988 S-adenosylmethionine binding site [chemical binding]; other site 697303002989 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 697303002990 radical SAM methylthiotransferase, MiaB/RimO family; Region: TIGR00089 697303002991 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 697303002992 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303002993 FeS/SAM binding site; other site 697303002994 TRAM domain; Region: TRAM; cl01282 697303002995 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 697303002996 nucleotide binding site/active site [active] 697303002997 HIT family signature motif; other site 697303002998 catalytic residue [active] 697303002999 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 697303003000 GatB domain; Region: GatB_Yqey; cl11497 697303003001 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 697303003002 active site 697303003003 homotetramer interface [polypeptide binding]; other site 697303003004 homodimer interface [polypeptide binding]; other site 697303003005 YabP family; Region: YabP; cl06766 697303003006 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 697303003007 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 697303003008 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 697303003009 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303003010 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 697303003011 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 697303003012 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303003013 Zn2+ binding site [ion binding]; other site 697303003014 Mg2+ binding site [ion binding]; other site 697303003015 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 697303003016 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; cl00526 697303003017 PAP2_like proteins, diacylglycerol_kinase like sub-family. In some prokaryotes, PAP2_like phosphatase domains appear fused to E. coli DAGK-like trans-membrane diacylglycerol kinase domains. The cellular function of these architectures remains to be...; Region: PAP2_diacylglycerolkinase; cd03383 697303003018 active site 697303003019 Transposase domain (DUF772); Region: DUF772; cl12084 697303003020 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303003021 GTPase Era; Reviewed; Region: era; PRK00089 697303003022 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit, possibly...; Region: Era; cd04163 697303003023 G1 box; other site 697303003024 GTP/Mg2+ binding site [chemical binding]; other site 697303003025 Switch I region; other site 697303003026 G2 box; other site 697303003027 Switch II region; other site 697303003028 G3 box; other site 697303003029 G4 box; other site 697303003030 G5 box; other site 697303003031 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that...; Region: KH-I; cl00098 697303003032 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 697303003033 intersubunit interface [polypeptide binding]; other site 697303003034 active site 697303003035 catalytic residue [active] 697303003036 Recombination protein O N terminal; Region: RecO_N; pfam11967 697303003037 DNA repair protein RecO; Region: reco; TIGR00613 697303003038 Recombination protein O C terminal; Region: RecO_C; pfam02565 697303003039 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 697303003040 glycyl-tRNA synthetase; Provisional; Region: PRK04173 697303003041 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 697303003042 motif 1; other site 697303003043 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3'...; Region: GlyRS-like_core; cd00774 697303003044 active site 697303003045 motif 2; other site 697303003046 motif 3; other site 697303003047 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 697303003048 anticodon binding site; other site 697303003049 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303003050 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617 697303003051 FOG: CBS domain [General function prediction only]; Region: COG0517 697303003052 Domain of unknown function (DUF299); Region: DUF299; cl00780 697303003053 pyruvate phosphate dikinase; Provisional; Region: PRK09279 697303003054 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 697303003055 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 697303003056 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 697303003057 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303003058 ribonuclease R; Region: RNase_R; TIGR02063 697303003059 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 697303003060 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 697303003061 RNB domain; Region: RNB; pfam00773 697303003062 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an important...; Region: S1_RNase_R; cd04471 697303003063 RNA binding site [nucleotide binding]; other site 697303003064 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 697303003065 SmpB-tmRNA interface; other site 697303003066 Protein of unknown function (DUF969); Region: DUF969; cl01573 697303003067 Protein of unknown function (DUF979); Region: DUF979; cl01572 697303003068 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 697303003069 putative substrate binding pocket [chemical binding]; other site 697303003070 AC domain interface; other site 697303003071 catalytic triad [active] 697303003072 AB domain interface; other site 697303003073 interchain disulfide; other site 697303003074 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 697303003075 ligand binding site [chemical binding]; other site 697303003076 flexible hinge region; other site 697303003077 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 697303003078 proposed catalytic triad [active] 697303003079 conserved cys residue [active] 697303003080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303003081 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 697303003082 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 697303003083 active site 697303003084 FMN binding site [chemical binding]; other site 697303003085 substrate binding site [chemical binding]; other site 697303003086 putative catalytic residue [active] 697303003087 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003088 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003089 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 697303003090 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 697303003091 4Fe-4S binding domain; Region: Fer4; cl02805 697303003092 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303003093 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303003094 Walker A motif; other site 697303003095 ATP binding site [chemical binding]; other site 697303003096 Walker B motif; other site 697303003097 arginine finger; other site 697303003098 Peptidase family M48; Region: Peptidase_M48; cl12018 697303003099 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 697303003100 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 697303003101 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303003102 FeS/SAM binding site; other site 697303003103 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 697303003104 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 697303003105 active site 697303003106 catalytic site [active] 697303003107 metal binding site [ion binding]; metal-binding site 697303003108 dimer interface [polypeptide binding]; other site 697303003109 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303003110 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697303003111 putative substrate translocation pore; other site 697303003112 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 697303003113 putative ADP-ribose binding site [chemical binding]; other site 697303003114 putative active site [active] 697303003115 Bacitracin resistance protein BacA; Region: BacA; cl00858 697303003116 small acid-soluble spore protein SspI; Provisional; Region: PRK02955; cl07940 697303003117 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 697303003118 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 697303003119 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303003120 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 697303003121 Low molecular weight phosphatase family; Region: LMWPc; cd00115 697303003122 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 697303003123 active site 697303003124 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 697303003125 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003126 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 697303003127 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 697303003128 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 697303003129 Putative cyclase; Region: Cyclase; cl00814 697303003130 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 697303003131 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 697303003132 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 697303003133 putative L-serine binding site [chemical binding]; other site 697303003134 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 697303003135 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 697303003136 oligoendopeptidase F; Region: pepF; TIGR00181 697303003137 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 697303003138 active site 697303003139 Zn binding site [ion binding]; other site 697303003140 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 697303003141 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 697303003142 active site 697303003143 dimer interface [polypeptide binding]; other site 697303003144 metal binding site [ion binding]; metal-binding site 697303003145 prephenate dehydratase; Provisional; Region: PRK11898 697303003146 Prephenate dehydratase; Region: PDT; pfam00800 697303003147 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 697303003148 putative L-Phe binding site [chemical binding]; other site 697303003149 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 697303003150 NeuB family; Region: NeuB; cl00496 697303003151 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 697303003152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003153 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 697303003154 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 697303003155 hinge; other site 697303003156 active site 697303003157 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697303003158 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303003159 active site 697303003160 phosphorylation site [posttranslational modification] 697303003161 intermolecular recognition site; other site 697303003162 dimerization interface [polypeptide binding]; other site 697303003163 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303003164 DNA binding site [nucleotide binding] 697303003165 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 697303003166 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303003167 dimerization interface [polypeptide binding]; other site 697303003168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303003169 dimer interface [polypeptide binding]; other site 697303003170 phosphorylation site [posttranslational modification] 697303003171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303003172 ATP binding site [chemical binding]; other site 697303003173 Mg2+ binding site [ion binding]; other site 697303003174 G-X-G motif; other site 697303003175 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 697303003176 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27); Region: Auto_anti-p27; cl00713 697303003177 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303003178 putative peptidoglycan binding site; other site 697303003179 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 697303003180 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303003181 putative peptidoglycan binding site; other site 697303003182 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 697303003183 Predicted membrane protein [Function unknown]; Region: COG2119 697303003184 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 697303003185 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 697303003186 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 697303003187 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 697303003188 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697303003189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303003190 active site 697303003191 phosphorylation site [posttranslational modification] 697303003192 intermolecular recognition site; other site 697303003193 dimerization interface [polypeptide binding]; other site 697303003194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303003195 DNA binding site [nucleotide binding] 697303003196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 697303003197 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 697303003198 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303003199 dimer interface [polypeptide binding]; other site 697303003200 phosphorylation site [posttranslational modification] 697303003201 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303003202 ATP binding site [chemical binding]; other site 697303003203 Mg2+ binding site [ion binding]; other site 697303003204 G-X-G motif; other site 697303003205 Predicted membrane protein (DUF2078); Region: DUF2078; cl01373 697303003206 Creatinine amidohydrolase; Region: Creatininase; cl00618 697303003207 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 697303003208 putative trimer interface [polypeptide binding]; other site 697303003209 putative CoA binding site [chemical binding]; other site 697303003210 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 697303003211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303003212 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697303003213 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303003214 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303003215 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 697303003216 active site 697303003217 trimer interface [polypeptide binding]; other site 697303003218 allosteric site; other site 697303003219 active site lid [active] 697303003220 hexamer (dimer of trimers) interface [polypeptide binding]; other site 697303003221 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 697303003222 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697303003223 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 697303003224 Walker A/P-loop; other site 697303003225 ATP binding site [chemical binding]; other site 697303003226 Q-loop/lid; other site 697303003227 ABC transporter signature motif; other site 697303003228 Walker B; other site 697303003229 D-loop; other site 697303003230 H-loop/switch region; other site 697303003231 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl00515 697303003232 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 697303003233 catalytic residues [active] 697303003234 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697303003235 catalytic residues [active] 697303003236 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 697303003237 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 697303003238 homodimer interface [polypeptide binding]; other site 697303003239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303003240 catalytic residue [active] 697303003241 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 697303003242 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 697303003243 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 697303003244 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 697303003245 catalytic loop [active] 697303003246 iron binding site [ion binding]; other site 697303003247 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 697303003248 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303003249 Walker A/P-loop; other site 697303003250 ATP binding site [chemical binding]; other site 697303003251 ABC transporter signature motif; other site 697303003252 Walker B; other site 697303003253 D-loop; other site 697303003254 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303003255 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303003256 Walker A motif; other site 697303003257 ATP binding site [chemical binding]; other site 697303003258 Walker B motif; other site 697303003259 arginine finger; other site 697303003260 Integrase core domain; Region: rve; cl01316 697303003261 IS2 transposase TnpB; Reviewed; Region: PRK09409 697303003262 YmaF family; Region: YmaF; pfam12788 697303003263 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303003264 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 697303003265 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 697303003266 G1 box; other site 697303003267 GTP/Mg2+ binding site [chemical binding]; other site 697303003268 Switch I region; other site 697303003269 G2 box; other site 697303003270 G3 box; other site 697303003271 Switch II region; other site 697303003272 G4 box; other site 697303003273 G5 box; other site 697303003274 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 697303003275 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 697303003276 active site 697303003277 Ap6A binding site [chemical binding]; other site 697303003278 nudix motif; other site 697303003279 metal binding site [ion binding]; metal-binding site 697303003280 uncharacterized protein, YigZ family; Region: IMPACT_YIGZ; TIGR00257 697303003281 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 697303003282 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 697303003283 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 697303003284 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303003285 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303003286 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003287 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 697303003288 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 697303003289 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 697303003290 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 697303003291 dimer interface [polypeptide binding]; other site 697303003292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303003293 catalytic residue [active] 697303003294 Domain of unknown function DUF28; Region: DUF28; cl00361 697303003295 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 697303003296 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 697303003297 active site 697303003298 putative DNA-binding cleft [nucleotide binding]; other site 697303003299 dimer interface [polypeptide binding]; other site 697303003300 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 697303003301 RuvA N terminal domain; Region: RuvA_N; pfam01330 697303003302 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 697303003303 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 697303003304 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303003305 Walker A motif; other site 697303003306 ATP binding site [chemical binding]; other site 697303003307 Walker B motif; other site 697303003308 arginine finger; other site 697303003309 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 697303003310 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 697303003311 Stage II sporulation protein; Region: SpoIID; pfam08486 697303003312 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 697303003313 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 697303003314 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 697303003315 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 697303003316 Preprotein translocase subunit; Region: YajC; cl00806 697303003317 Protein of unknown function (DUF3792); Region: DUF3792; cl14821 697303003318 rSAM-modified six-cysteine peptide SCIFF; Region: six_Cys_in_45; TIGR03973 697303003319 six-Cys-in-45 modification radical SAM protein; Region: rSAM_six_Cys; TIGR03974 697303003320 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303003321 FeS/SAM binding site; other site 697303003322 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 697303003323 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 697303003324 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 697303003325 trimer interface [polypeptide binding]; other site 697303003326 putative metal binding site [ion binding]; other site 697303003327 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 697303003328 Protein export membrane protein; Region: SecD_SecF; cl14618 697303003329 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 697303003330 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 697303003331 Protein export membrane protein; Region: SecD_SecF; cl14618 697303003332 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 697303003333 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697303003334 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 697303003335 active site 697303003336 ATP binding site [chemical binding]; other site 697303003337 substrate binding site [chemical binding]; other site 697303003338 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 697303003339 DHH family; Region: DHH; pfam01368 697303003340 DHHA1 domain; Region: DHHA1; pfam02272 697303003341 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 697303003342 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303003343 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 697303003344 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303003345 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 697303003346 synthetase active site [active] 697303003347 NTP binding site [chemical binding]; other site 697303003348 metal binding site [ion binding]; metal-binding site 697303003349 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 697303003350 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 697303003351 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 697303003352 putative active site [active] 697303003353 dimerization interface [polypeptide binding]; other site 697303003354 putative tRNAtyr binding site [nucleotide binding]; other site 697303003355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303003356 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 697303003357 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 697303003358 FtsX-like permease family; Region: FtsX; pfam02687 697303003359 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 697303003360 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 697303003361 Walker A/P-loop; other site 697303003362 ATP binding site [chemical binding]; other site 697303003363 Q-loop/lid; other site 697303003364 ABC transporter signature motif; other site 697303003365 Walker B; other site 697303003366 D-loop; other site 697303003367 H-loop/switch region; other site 697303003368 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 697303003369 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 697303003370 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303003371 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303003372 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 697303003373 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 697303003374 dimer interface [polypeptide binding]; other site 697303003375 motif 1; other site 697303003376 active site 697303003377 motif 2; other site 697303003378 motif 3; other site 697303003379 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 697303003380 anticodon binding site; other site 697303003381 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 697303003382 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 697303003383 dimer interface [polypeptide binding]; other site 697303003384 anticodon binding site; other site 697303003385 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 697303003386 homodimer interface [polypeptide binding]; other site 697303003387 motif 1; other site 697303003388 active site 697303003389 motif 2; other site 697303003390 GAD domain; Region: GAD; pfam02938 697303003391 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 697303003392 motif 3; other site 697303003393 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 697303003394 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 697303003395 putative ATP binding site [chemical binding]; other site 697303003396 putative substrate interface [chemical binding]; other site 697303003397 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 697303003398 putative homotetramer interface [polypeptide binding]; other site 697303003399 putative homodimer interface [polypeptide binding]; other site 697303003400 putative allosteric switch controlling residues; other site 697303003401 putative metal binding site [ion binding]; other site 697303003402 putative homodimer-homodimer interface [polypeptide binding]; other site 697303003403 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 697303003404 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697303003405 catalytic residues [active] 697303003406 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697303003407 catalytic residues [active] 697303003408 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 697303003409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003410 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 697303003411 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 697303003412 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303003413 catalytic residue [active] 697303003414 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 697303003415 D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043 697303003416 B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067 697303003417 B12 binding site [chemical binding]; other site 697303003418 cobalt ligand [ion binding]; other site 697303003419 conserved hypothetical protein; Region: glmL_fam; TIGR01319 697303003420 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 697303003421 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 697303003422 dimer interface [polypeptide binding]; other site 697303003423 active site 697303003424 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697303003425 substrate binding site [chemical binding]; other site 697303003426 catalytic residue [active] 697303003427 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697303003428 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 697303003429 active site 697303003430 metal binding site [ion binding]; metal-binding site 697303003431 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303003432 Rrf2 family protein; Region: rrf2_super; TIGR00738 697303003433 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 697303003434 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 697303003435 Ligand Binding Site [chemical binding]; other site 697303003436 Domain of unknown function DUF20; Region: UPF0118; cl00465 697303003437 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 697303003438 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: AlaRS_core; cd00673 697303003439 motif 1; other site 697303003440 active site 697303003441 motif 2; other site 697303003442 motif 3; other site 697303003443 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 697303003444 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 697303003445 DHHA1 domain; Region: DHHA1; pfam02272 697303003446 Bacterial protein of unknown function (DUF965); Region: DUF965; cl01857 697303003447 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cl00243 697303003448 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 697303003449 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697303003450 metal binding site 2 [ion binding]; metal-binding site 697303003451 putative DNA binding helix; other site 697303003452 metal binding site 1 [ion binding]; metal-binding site 697303003453 dimer interface [polypeptide binding]; other site 697303003454 structural Zn2+ binding site [ion binding]; other site 697303003455 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 697303003456 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303003457 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 697303003458 Protein of unknown function (DUF964); Region: DUF964; cl01483 697303003459 QueT transporter; Region: QueT; cl01932 697303003460 YceG-like family; Region: YceG; pfam02618 697303003461 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 697303003462 dimerization interface [polypeptide binding]; other site 697303003463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303003464 S-adenosylmethionine binding site [chemical binding]; other site 697303003465 putative protease; Provisional; Region: PRK15452 697303003466 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 697303003467 Peptidase family U32; Region: Peptidase_U32; cl03113 697303003468 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 697303003469 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697303003470 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 697303003471 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 697303003472 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303003473 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303003474 DNA binding residues [nucleotide binding] 697303003475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303003476 active site 697303003477 motif I; other site 697303003478 motif II; other site 697303003479 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 697303003480 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 697303003481 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 697303003482 shikimate binding site; other site 697303003483 NAD(P) binding site [chemical binding]; other site 697303003484 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 697303003485 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 697303003486 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 697303003487 Walker A motif; other site 697303003488 ATP binding site [chemical binding]; other site 697303003489 Walker B motif; other site 697303003490 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 697303003491 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303003492 Walker A motif; other site 697303003493 ATP binding site [chemical binding]; other site 697303003494 Walker B motif; other site 697303003495 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 697303003496 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 697303003497 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 697303003498 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 697303003499 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 697303003500 Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970 697303003501 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 697303003502 general secretion pathway protein I; Region: gspI; TIGR01707 697303003503 Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966 697303003504 Prokaryotic N-terminal methylation motif; Region: N_methyl; cl06830 697303003505 Late competence development protein ComFB; Region: ComFB; pfam10719 697303003506 Cell division protein FtsA; Region: FtsA; cl11496 697303003507 Cell division protein FtsA; Region: FtsA; cl11496 697303003508 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 697303003509 Pilus assembly protein, PilO; Region: PilO; cl01234 697303003510 shikimate kinase; Reviewed; Region: aroK; PRK00131 697303003511 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 697303003512 ADP binding site [chemical binding]; other site 697303003513 magnesium binding site [ion binding]; other site 697303003514 putative shikimate binding site; other site 697303003515 AP endonuclease family 2; Region: AP2Ec; smart00518 697303003516 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 697303003517 AP (apurinic/apyrimidinic) site pocket; other site 697303003518 DNA interaction; other site 697303003519 Metal-binding active site; metal-binding site 697303003520 gamma-glutamyl kinase; Provisional; Region: PRK05429 697303003521 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 697303003522 nucleotide binding site [chemical binding]; other site 697303003523 homotetrameric interface [polypeptide binding]; other site 697303003524 putative phosphate binding site [ion binding]; other site 697303003525 putative allosteric binding site; other site 697303003526 PUA domain; Region: PUA; cl00607 697303003527 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 697303003528 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 697303003529 putative catalytic cysteine [active] 697303003530 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 697303003531 trimer interface [polypeptide binding]; other site 697303003532 active site 697303003533 dimer interface [polypeptide binding]; other site 697303003534 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 697303003535 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 697303003536 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 697303003537 active site 697303003538 elongation factor P; Validated; Region: PRK00529 697303003539 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 697303003540 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 697303003541 RNA binding site [nucleotide binding]; other site 697303003542 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 697303003543 RNA binding site [nucleotide binding]; other site 697303003544 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 697303003545 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303003546 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 697303003547 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 697303003548 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 697303003549 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; cl09771 697303003550 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; cl09803 697303003551 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 697303003552 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 697303003553 Protein of unknown function (DUF322); Region: DUF322; cl00574 697303003554 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 697303003555 putative RNA binding site [nucleotide binding]; other site 697303003556 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14178 697303003557 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 697303003558 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 697303003559 homodimer interface [polypeptide binding]; other site 697303003560 NADP binding site [chemical binding]; other site 697303003561 substrate binding site [chemical binding]; other site 697303003562 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 697303003563 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 697303003564 generic binding surface II; other site 697303003565 generic binding surface I; other site 697303003566 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 697303003567 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 697303003568 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 697303003569 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 697303003570 substrate binding pocket [chemical binding]; other site 697303003571 chain length determination region; other site 697303003572 substrate-Mg2+ binding site; other site 697303003573 catalytic residues [active] 697303003574 aspartate-rich region 1; other site 697303003575 active site lid residues [active] 697303003576 aspartate-rich region 2; other site 697303003577 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 697303003578 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 697303003579 TPP-binding site; other site 697303003580 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697303003581 PYR/PP interface [polypeptide binding]; other site 697303003582 dimer interface [polypeptide binding]; other site 697303003583 TPP binding site [chemical binding]; other site 697303003584 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303003585 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 697303003586 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303003587 RNA binding surface [nucleotide binding]; other site 697303003588 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303003589 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 697303003590 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 697303003591 arginine repressor; Provisional; Region: argR; PRK00441 697303003592 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 697303003593 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 697303003594 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 697303003595 Walker A/P-loop; other site 697303003596 ATP binding site [chemical binding]; other site 697303003597 Q-loop/lid; other site 697303003598 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides, and...; Region: ABC_RecN; cd03241 697303003599 ABC transporter signature motif; other site 697303003600 Walker B; other site 697303003601 D-loop; other site 697303003602 H-loop/switch region; other site 697303003603 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 697303003604 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697303003605 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 697303003606 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 697303003607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303003608 active site 697303003609 phosphorylation site [posttranslational modification] 697303003610 intermolecular recognition site; other site 697303003611 dimerization interface [polypeptide binding]; other site 697303003612 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 697303003613 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 697303003614 Thiamine pyrophosphokinase; Region: TPK; cl09135 697303003615 active site 697303003616 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 697303003617 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 697303003618 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 697303003619 Ligand binding site; other site 697303003620 Putative Catalytic site; other site 697303003621 DXD motif; other site 697303003622 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 697303003623 Mg++ binding site [ion binding]; other site 697303003624 putative catalytic motif [active] 697303003625 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 697303003626 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 697303003627 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 697303003628 dimer interface [polypeptide binding]; other site 697303003629 ADP-ribose binding site [chemical binding]; other site 697303003630 active site 697303003631 nudix motif; other site 697303003632 metal binding site [ion binding]; metal-binding site 697303003633 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 697303003634 Integral membrane protein DUF95; Region: DUF95; cl00572 697303003635 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697303003636 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 697303003637 DNA binding site [nucleotide binding] 697303003638 active site 697303003639 Int/Topo IB signature motif; other site 697303003640 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 697303003641 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 697303003642 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 697303003643 anti sigma factor interaction site; other site 697303003644 regulatory phosphorylation site [posttranslational modification]; other site 697303003645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303003646 ATP binding site [chemical binding]; other site 697303003647 Mg2+ binding site [ion binding]; other site 697303003648 G-X-G motif; other site 697303003649 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 697303003650 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303003651 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697303003652 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303003653 DNA binding residues [nucleotide binding] 697303003654 Protein of unknown function (DUF1458); Region: DUF1458; cl01328 697303003655 SpoVA protein; Region: SpoVA; cl04298 697303003656 stage V sporulation protein AD; Validated; Region: PRK08304 697303003657 stage V sporulation protein AD; Provisional; Region: PRK12404 697303003658 SpoVA protein; Region: SpoVA; cl04298 697303003659 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 697303003660 active site 697303003661 NTP binding site [chemical binding]; other site 697303003662 metal binding triad [ion binding]; metal-binding site 697303003663 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 697303003664 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 697303003665 active site 697303003666 putative substrate binding region [chemical binding]; other site 697303003667 ScpA/B protein; Region: ScpA_ScpB; cl00598 697303003668 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 697303003669 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303003670 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303003671 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303003672 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303003673 Integrase core domain; Region: rve; cl01316 697303003674 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 697303003675 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 697303003676 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303003677 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303003678 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 697303003679 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814 697303003680 hypothetical protein; Provisional; Region: PRK05802 697303003681 FAD/NAD binding domain (electron transfer subunit) of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate...; Region: DHOD_e_trans_like; cd06192 697303003682 FAD binding pocket [chemical binding]; other site 697303003683 FAD binding motif [chemical binding]; other site 697303003684 phosphate binding motif [ion binding]; other site 697303003685 beta-alpha-beta structure motif; other site 697303003686 NAD binding pocket [chemical binding]; other site 697303003687 Iron coordination center [ion binding]; other site 697303003688 Glucose inhibited division protein A; Region: GIDA; pfam01134 697303003689 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003690 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 697303003691 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 697303003692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303003693 RNA binding surface [nucleotide binding]; other site 697303003694 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 697303003695 active site 697303003696 spermidine synthase; Provisional; Region: PRK00811 697303003697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303003698 S-adenosylmethionine binding site [chemical binding]; other site 697303003699 Arginase family; Region: Arginase; cl00306 697303003700 oxaloacetate decarboxylase; Provisional; Region: PRK12331 697303003701 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 697303003702 active site 697303003703 catalytic residues [active] 697303003704 metal binding site [ion binding]; metal-binding site 697303003705 homodimer binding site [polypeptide binding]; other site 697303003706 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 697303003707 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303003708 putative peptidoglycan binding site; other site 697303003709 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303003710 putative peptidoglycan binding site; other site 697303003711 Survival protein SurE; Region: SurE; cl00448 697303003712 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 697303003713 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 697303003714 2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659 697303003715 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 697303003716 dimer interface [polypeptide binding]; other site 697303003717 PYR/PP interface [polypeptide binding]; other site 697303003718 TPP binding site [chemical binding]; other site 697303003719 substrate binding site [chemical binding]; other site 697303003720 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303003721 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 697303003722 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 697303003723 TPP-binding site [chemical binding]; other site 697303003724 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 697303003725 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 697303003726 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 697303003727 putative active site [active] 697303003728 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 697303003729 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 697303003730 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 697303003731 NAD(P) binding site [chemical binding]; other site 697303003732 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697303003733 catalytic core [active] 697303003734 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003735 flavoprotein, HI0933 family; Region: TIGR00275 697303003736 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 697303003737 homotrimer interaction site [polypeptide binding]; other site 697303003738 active site 697303003739 cytidylate kinase; Provisional; Region: cmk; PRK00023 697303003740 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 697303003741 CMP-binding site; other site 697303003742 The sites determining sugar specificity; other site 697303003743 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 697303003744 putative acyl-acceptor binding pocket; other site 697303003745 LytB protein; Region: LYTB; cl00507 697303003746 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 697303003747 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 697303003748 RNA binding site [nucleotide binding]; other site 697303003749 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 697303003750 RNA binding site [nucleotide binding]; other site 697303003751 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 697303003752 RNA binding site [nucleotide binding]; other site 697303003753 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 697303003754 RNA binding site [nucleotide binding]; other site 697303003755 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303003756 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303003757 dimerization interface [polypeptide binding]; other site 697303003758 putative DNA binding site [nucleotide binding]; other site 697303003759 putative Zn2+ binding site [ion binding]; other site 697303003760 Integrase core domain; Region: rve; cl01316 697303003761 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 697303003762 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 697303003763 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 697303003764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303003765 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328 697303003766 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 697303003767 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303003768 FeS/SAM binding site; other site 697303003769 TRAM domain; Region: TRAM; cl01282 697303003770 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 697303003771 MutS domain I; Region: MutS_I; pfam01624 697303003772 MutS domain II; Region: MutS_II; pfam05188 697303003773 MutS family domain IV; Region: MutS_IV; pfam05190 697303003774 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 697303003775 Walker A/P-loop; other site 697303003776 ATP binding site [chemical binding]; other site 697303003777 Q-loop/lid; other site 697303003778 ABC transporter signature motif; other site 697303003779 Walker B; other site 697303003780 D-loop; other site 697303003781 H-loop/switch region; other site 697303003782 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 697303003783 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 697303003784 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 697303003785 ATP binding site [chemical binding]; other site 697303003786 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 697303003787 IPP transferase; Region: IPPT; cl00403 697303003788 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 697303003789 Hfq, an abundant, ubiquitous RNA-binding protein, functions as a pleiotrophic regulator of RNA metabolism in prokaryotes, required for transcription of some transcripts and degradation of others. Hfq binds small RNA molecules called riboregulators that...; Region: Hfq; cd01716 697303003790 Sm1 motif; other site 697303003791 intra - hexamer interaction site; other site 697303003792 inter - hexamer interaction site [polypeptide binding]; other site 697303003793 nucleotide binding pocket [chemical binding]; other site 697303003794 Sm2 motif; other site 697303003795 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303003796 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 697303003797 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 697303003798 RNA/DNA hybrid binding site [nucleotide binding]; other site 697303003799 active site 697303003800 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 697303003801 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697303003802 DNA binding site [nucleotide binding] 697303003803 Int/Topo IB signature motif; other site 697303003804 active site 697303003805 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 697303003806 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697303003807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303003808 catalytic residue [active] 697303003809 stage V sporulation protein K; Region: spore_V_K; TIGR02881 697303003810 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303003811 Walker A motif; other site 697303003812 ATP binding site [chemical binding]; other site 697303003813 Walker B motif; other site 697303003814 arginine finger; other site 697303003815 adenylosuccinate lyase; Region: purB; TIGR00928 697303003816 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 697303003817 tetramer interface [polypeptide binding]; other site 697303003818 active site 697303003819 aspartate aminotransferase; Provisional; Region: PRK05764 697303003820 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697303003821 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303003822 homodimer interface [polypeptide binding]; other site 697303003823 catalytic residue [active] 697303003824 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 697303003825 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303003826 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 697303003827 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 697303003828 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 697303003829 putative active site [active] 697303003830 metal binding site [ion binding]; metal-binding site 697303003831 homodimer binding site [polypeptide binding]; other site 697303003832 phosphodiesterase; Provisional; Region: PRK12704 697303003833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303003834 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303003835 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303003836 dimerization interface [polypeptide binding]; other site 697303003837 putative DNA binding site [nucleotide binding]; other site 697303003838 putative Zn2+ binding site [ion binding]; other site 697303003839 Integrase core domain; Region: rve; cl01316 697303003840 RecX family; Region: RecX; cl00936 697303003841 recombinase A; Provisional; Region: recA; PRK09354 697303003842 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 697303003843 hexamer interface [polypeptide binding]; other site 697303003844 Walker A motif; other site 697303003845 ATP binding site [chemical binding]; other site 697303003846 Walker B motif; other site 697303003847 competence damage-inducible protein A; Provisional; Region: PRK00549 697303003848 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 697303003849 putative MPT binding site; other site 697303003850 Competence-damaged protein; Region: CinA; cl00666 697303003851 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 697303003852 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 697303003853 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 697303003854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303003855 FeS/SAM binding site; other site 697303003856 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303003857 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 697303003858 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl14780 697303003859 active site 697303003860 aspartate kinase I; Reviewed; Region: PRK08210 697303003861 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 697303003862 nucleotide binding site [chemical binding]; other site 697303003863 substrate binding site [chemical binding]; other site 697303003864 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 697303003865 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_2; cd04937 697303003866 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 697303003867 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 697303003868 trimer interface [polypeptide binding]; other site 697303003869 active site 697303003870 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697303003871 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 697303003872 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697303003873 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 697303003874 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 697303003875 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 697303003876 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 697303003877 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 697303003878 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 697303003879 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 697303003880 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 697303003881 putative nucleic acid binding region [nucleotide binding]; other site 697303003882 G-X-X-G motif; other site 697303003883 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 697303003884 RNA binding site [nucleotide binding]; other site 697303003885 domain interface; other site 697303003886 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 697303003887 16S/18S rRNA binding site [nucleotide binding]; other site 697303003888 S13e-L30e interaction site [polypeptide binding]; other site 697303003889 25S rRNA binding site [nucleotide binding]; other site 697303003890 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 697303003891 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 697303003892 active site 697303003893 Riboflavin kinase; Region: Flavokinase; cl03312 697303003894 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 697303003895 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of specific...; Region: PseudoU_synth_EcTruB; cd02573 697303003896 RNA binding site [nucleotide binding]; other site 697303003897 active site 697303003898 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 697303003899 DHH family; Region: DHH; pfam01368 697303003900 DHHA1 domain; Region: DHHA1; pfam02272 697303003901 Ribosome-binding factor A; Region: RBFA; cl00542 697303003902 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 697303003903 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 697303003904 translation initiation factor IF-2; Region: IF-2; TIGR00487 697303003905 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases; Region: IF2_eIF5B; cd01887 697303003906 G1 box; other site 697303003907 putative GEF interaction site [polypeptide binding]; other site 697303003908 GTP/Mg2+ binding site [chemical binding]; other site 697303003909 Switch I region; other site 697303003910 G2 box; other site 697303003911 G3 box; other site 697303003912 Switch II region; other site 697303003913 G4 box; other site 697303003914 G5 box; other site 697303003915 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 697303003916 Translation-initiation factor 2; Region: IF-2; pfam11987 697303003917 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 697303003918 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 697303003919 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 697303003920 putative RNA binding cleft [nucleotide binding]; other site 697303003921 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 697303003922 NusA N-terminal domain; Region: NusA_N; pfam08529 697303003923 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 697303003924 RNA binding site [nucleotide binding]; other site 697303003925 homodimer interface [polypeptide binding]; other site 697303003926 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 697303003927 G-X-X-G motif; other site 697303003928 ribosome maturation protein RimP; Reviewed; Region: PRK00092 697303003929 The eukaryotic Sm and Sm-like (LSm) proteins associate with RNA to form the core domain of the ribonucleoprotein particles involved in a variety of RNA processing events including pre-mRNA splicing, telomere replication, and mRNA degradation. Members of...; Region: Sm_like; cl00259 697303003930 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 697303003931 Sm1 motif; other site 697303003932 predicted subunit interaction site [polypeptide binding]; other site 697303003933 RNA binding pocket [nucleotide binding]; other site 697303003934 Sm2 motif; other site 697303003935 DNA polymerase III PolC; Validated; Region: polC; PRK00448 697303003936 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 697303003937 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 697303003938 generic binding surface I; other site 697303003939 generic binding surface II; other site 697303003940 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303003941 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 697303003942 active site 697303003943 substrate binding site [chemical binding]; other site 697303003944 catalytic site [active] 697303003945 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 697303003946 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 697303003947 Ligand binding site; other site 697303003948 Putative Catalytic site; other site 697303003949 DXD motif; other site 697303003950 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694; cl15446 697303003951 GcpE protein; Region: GcpE; pfam04551 697303003952 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 697303003953 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 697303003954 active site 697303003955 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 697303003956 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 697303003957 putative substrate binding region [chemical binding]; other site 697303003958 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 697303003959 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 697303003960 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 697303003961 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 697303003962 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 697303003963 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 697303003964 catalytic residue [active] 697303003965 putative FPP diphosphate binding site; other site 697303003966 putative FPP binding hydrophobic cleft; other site 697303003967 dimer interface [polypeptide binding]; other site 697303003968 putative IPP diphosphate binding site; other site 697303003969 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 697303003970 hinge region; other site 697303003971 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 697303003972 putative nucleotide binding site [chemical binding]; other site 697303003973 uridine monophosphate binding site [chemical binding]; other site 697303003974 homohexameric interface [polypeptide binding]; other site 697303003975 elongation factor Ts; Reviewed; Region: tsf; PRK12332 697303003976 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 697303003977 Elongation factor TS; Region: EF_TS; pfam00889 697303003978 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 697303003979 rRNA interaction site [nucleotide binding]; other site 697303003980 S8 interaction site; other site 697303003981 putative laminin-1 binding site; other site 697303003982 Protein of unknown function (DUF342); Region: DUF342; pfam03961 697303003983 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 697303003984 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303003985 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697303003986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303003987 DNA binding residues [nucleotide binding] 697303003988 CheD chemotactic sensory transduction; Region: CheD; cl00810 697303003989 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 697303003990 CheC-like family; Region: CheC; pfam04509 697303003991 CheC-like family; Region: CheC; pfam04509 697303003992 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 697303003993 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 697303003994 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 697303003995 putative binding surface; other site 697303003996 active site 697303003997 P2 response regulator binding domain; Region: P2; pfam07194 697303003998 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 697303003999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303004000 ATP binding site [chemical binding]; other site 697303004001 Mg2+ binding site [ion binding]; other site 697303004002 G-X-G motif; other site 697303004003 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 697303004004 CheB methylesterase; Region: CheB_methylest; pfam01339 697303004005 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 697303004006 Flagellar protein YcgR; Region: YcgR_2; pfam12945 697303004007 PilZ domain; Region: PilZ; cl01260 697303004008 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303004009 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 697303004010 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 697303004011 Flagellar GTP-binding protein [Cell motility and secretion]; Region: FlhF; COG1419 697303004012 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303004013 flagellar biosynthesis protein FlhA; Validated; Region: flhA; cl07980 697303004014 FHIPEP family; Region: FHIPEP; pfam00771 697303004015 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 697303004016 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 697303004017 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 697303004018 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 697303004019 FliP family; Region: FliP; cl00593 697303004020 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 697303004021 Response regulator receiver domain; Region: Response_reg; pfam00072 697303004022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303004023 active site 697303004024 phosphorylation site [posttranslational modification] 697303004025 intermolecular recognition site; other site 697303004026 dimerization interface [polypeptide binding]; other site 697303004027 flagellar motor switch protein; Validated; Region: PRK08119 697303004028 CheC-like family; Region: CheC; pfam04509 697303004029 CheC-like family; Region: CheC; pfam04509 697303004030 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 697303004031 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 697303004032 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 697303004033 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 697303004034 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 697303004035 Flagellar protein (FlbD); Region: FlbD; cl00683 697303004036 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 697303004037 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 697303004038 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 697303004039 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 697303004040 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 697303004041 Flagellar hook capping protein; Region: FlgD; cl04347 697303004042 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 697303004043 MgtE intracellular N domain; Region: MgtE_N; cl15244 697303004044 Flagellar FliJ protein; Region: FliJ; cl09161 697303004045 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 697303004046 flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497 697303004047 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 697303004048 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 697303004049 Walker A motif/ATP binding site; other site 697303004050 Walker B motif; other site 697303004051 Flagellar assembly protein FliH; Region: FliH; pfam02108 697303004052 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 697303004053 MgtE intracellular N domain; Region: MgtE_N; cl15244 697303004054 FliG C-terminal domain; Region: FliG_C; pfam01706 697303004055 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 697303004056 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 697303004057 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 697303004058 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 697303004059 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 697303004060 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 697303004061 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 697303004062 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 697303004063 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 697303004064 transcriptional repressor CodY; Validated; Region: PRK04158 697303004065 CodY GAF-like domain; Region: CodY; pfam06018 697303004066 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303004067 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 697303004068 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303004069 Walker A motif; other site 697303004070 ATP binding site [chemical binding]; other site 697303004071 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303004072 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 697303004073 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 697303004074 active site 697303004075 HslU subunit interaction site [polypeptide binding]; other site 697303004076 DNA topoisomerase I; Validated; Region: PRK05582 697303004077 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 697303004078 active site 697303004079 interdomain interaction site; other site 697303004080 putative metal-binding site [ion binding]; other site 697303004081 nucleotide binding site [chemical binding]; other site 697303004082 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 697303004083 domain I; other site 697303004084 DNA binding groove [nucleotide binding] 697303004085 phosphate binding site [ion binding]; other site 697303004086 domain II; other site 697303004087 domain III; other site 697303004088 nucleotide binding site [chemical binding]; other site 697303004089 catalytic site [active] 697303004090 domain IV; other site 697303004091 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 697303004092 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 697303004093 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 697303004094 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 697303004095 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 697303004096 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303004097 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 697303004098 RNA/DNA hybrid binding site [nucleotide binding]; other site 697303004099 active site 697303004100 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 697303004101 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 697303004102 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 697303004103 active site 697303004104 HIGH motif; other site 697303004105 dimer interface [polypeptide binding]; other site 697303004106 KMSKS motif; other site 697303004107 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697303004108 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697303004109 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697303004110 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 697303004111 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 697303004112 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 697303004113 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303004114 Walker A motif; other site 697303004115 ATP binding site [chemical binding]; other site 697303004116 Walker B motif; other site 697303004117 arginine finger; other site 697303004118 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 697303004119 YlqF. Proteins of the YlqF family contain all sequence motifs typical of the vast class of P-loop-containing GTPases, but show a circular permutation, with a G4-G1-G3 pattern of motifs as opposed to the regular G1-G3-G4 pattern seen in most GTPases. The...; Region: YlqF; cd01856 697303004120 GTP/Mg2+ binding site [chemical binding]; other site 697303004121 G4 box; other site 697303004122 G5 box; other site 697303004123 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303004124 G1 box; other site 697303004125 G1 box; other site 697303004126 GTP/Mg2+ binding site [chemical binding]; other site 697303004127 Switch I region; other site 697303004128 G2 box; other site 697303004129 G2 box; other site 697303004130 Switch I region; other site 697303004131 G3 box; other site 697303004132 G3 box; other site 697303004133 Switch II region; other site 697303004134 Switch II region; other site 697303004135 G4 box; other site 697303004136 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 697303004137 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 697303004138 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 697303004139 RimM N-terminal domain; Region: RimM; pfam01782 697303004140 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 697303004141 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 697303004142 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 697303004143 signal recognition particle protein; Provisional; Region: PRK10867 697303004144 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 697303004145 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 697303004146 P loop; other site 697303004147 GTP binding site [chemical binding]; other site 697303004148 Signal peptide binding domain; Region: SRP_SPB; pfam02978 697303004149 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 697303004150 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303004151 DNA binding residues [nucleotide binding] 697303004152 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 697303004153 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 697303004154 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 697303004155 GTP binding site [chemical binding]; other site 697303004156 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 697303004157 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 697303004158 Walker A/P-loop; other site 697303004159 ATP binding site [chemical binding]; other site 697303004160 Q-loop/lid; other site 697303004161 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; cl05797 697303004162 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large; Region: ABC_SMC_barmotin; cd03278 697303004163 ABC transporter signature motif; other site 697303004164 Walker B; other site 697303004165 D-loop; other site 697303004166 H-loop/switch region; other site 697303004167 Stage V sporulation protein S (SpoVS); Region: SpoVS; cl01005 697303004168 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303004169 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 697303004170 FeS/SAM binding site; other site 697303004171 ribonuclease III; Reviewed; Region: rnc; PRK00102 697303004172 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 697303004173 dimerization interface [polypeptide binding]; other site 697303004174 active site 697303004175 metal binding site [ion binding]; metal-binding site 697303004176 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 697303004177 dsRNA binding site [nucleotide binding]; other site 697303004178 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 697303004179 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 697303004180 dimer interface [polypeptide binding]; other site 697303004181 active site 697303004182 Phosphopantetheine attachment site; Region: PP-binding; cl09936 697303004183 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 697303004184 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 697303004185 NAD(P) binding site [chemical binding]; other site 697303004186 homotetramer interface [polypeptide binding]; other site 697303004187 homodimer interface [polypeptide binding]; other site 697303004188 active site 697303004189 Acyl transferase domain; Region: Acyl_transf_1; cl08282 697303004190 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 697303004191 putative enoyl-(acyl-carrier-protein) reductase II; Region: enACPred_II; TIGR03151 697303004192 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 697303004193 FMN binding site [chemical binding]; other site 697303004194 substrate binding site [chemical binding]; other site 697303004195 putative catalytic residue [active] 697303004196 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 697303004197 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 697303004198 dimer interface [polypeptide binding]; other site 697303004199 active site 697303004200 CoA binding pocket [chemical binding]; other site 697303004201 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 697303004202 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 697303004203 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 697303004204 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 697303004205 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 697303004206 Acetokinase family; Region: Acetate_kinase; cl01029 697303004207 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 697303004208 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 697303004209 hypothetical protein; Provisional; Region: PRK13670 697303004210 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 697303004211 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 697303004212 Nucleoside recognition; Region: Gate; cl00486 697303004213 Nucleoside recognition; Region: Gate; cl00486 697303004214 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 697303004215 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 697303004216 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 697303004217 active site 697303004218 (T/H)XGH motif; other site 697303004219 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303004220 S-adenosylmethionine binding site [chemical binding]; other site 697303004221 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697303004222 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697303004223 Uncharacterised protein, DegV family COG1307; Region: DegV; cl00577 697303004224 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 697303004225 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 697303004226 generic binding surface II; other site 697303004227 ssDNA binding site; other site 697303004228 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697303004229 ATP binding site [chemical binding]; other site 697303004230 putative Mg++ binding site [ion binding]; other site 697303004231 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697303004232 nucleotide binding region [chemical binding]; other site 697303004233 ATP-binding site [chemical binding]; other site 697303004234 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 697303004235 DAK2 domain; Region: Dak2; cl03685 697303004236 Protein of unknown function (DUF322); Region: DUF322; cl00574 697303004237 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 697303004238 Thiamine pyrophosphokinase; Region: TPK; cd07995 697303004239 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 697303004240 active site 697303004241 dimerization interface [polypeptide binding]; other site 697303004242 thiamine binding site [chemical binding]; other site 697303004243 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 697303004244 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 697303004245 substrate binding site [chemical binding]; other site 697303004246 hexamer interface [polypeptide binding]; other site 697303004247 metal binding site [ion binding]; metal-binding site 697303004248 GTPase RsgA; Reviewed; Region: PRK00098 697303004249 YjeQ/EngC. YjeQ (YloQ in Bacillus subtilis) represents a protein family whose members are broadly conserved in bacteria and have been shown to be essential to the growth of E. coli and B. subtilis. Proteins of the YjeQ family contain all sequence motifs...; Region: YjeQ_engC; cd01854 697303004250 GTPase/OB domain interface [polypeptide binding]; other site 697303004251 GTPase/Zn-binding domain interface [polypeptide binding]; other site 697303004252 GTP/Mg2+ binding site [chemical binding]; other site 697303004253 G4 box; other site 697303004254 G5 box; other site 697303004255 G1 box; other site 697303004256 Switch I region; other site 697303004257 G2 box; other site 697303004258 G3 box; other site 697303004259 Switch II region; other site 697303004260 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697303004261 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 697303004262 active site 697303004263 ATP binding site [chemical binding]; other site 697303004264 substrate binding site [chemical binding]; other site 697303004265 activation loop (A-loop); other site 697303004266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697303004267 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697303004268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 697303004269 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 697303004270 Protein phosphatase 2C; Region: PP2C; pfam00481 697303004271 active site 697303004272 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 697303004273 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303004274 FeS/SAM binding site; other site 697303004275 16S rRNA methyltransferase B; Provisional; Region: PRK14902 697303004276 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 697303004277 putative RNA binding site [nucleotide binding]; other site 697303004278 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303004279 S-adenosylmethionine binding site [chemical binding]; other site 697303004280 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; cl01049 697303004281 Endomembrane protein 70; Region: EMP70; pfam02990 697303004282 Protein of unknown function DUF116; Region: DUF116; cl00800 697303004283 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 697303004284 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 697303004285 putative active site [active] 697303004286 substrate binding site [chemical binding]; other site 697303004287 putative cosubstrate binding site; other site 697303004288 catalytic site [active] 697303004289 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 697303004290 substrate binding site [chemical binding]; other site 697303004291 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 697303004292 active site 697303004293 catalytic residues [active] 697303004294 metal binding site [ion binding]; metal-binding site 697303004295 primosome assembly protein PriA; Validated; Region: PRK05580 697303004296 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303004297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697303004298 ATP binding site [chemical binding]; other site 697303004299 putative Mg++ binding site [ion binding]; other site 697303004300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697303004301 ATP-binding site [chemical binding]; other site 697303004302 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 697303004303 Flavoprotein; Region: Flavoprotein; cl08021 697303004304 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 697303004305 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 697303004306 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 697303004307 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 697303004308 catalytic site [active] 697303004309 G-X2-G-X-G-K; other site 697303004310 Domain of unknown function (DUF370); Region: DUF370; cl00898 697303004311 hypothetical protein; Provisional; Region: PRK11820 697303004312 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 697303004313 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 697303004314 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 697303004315 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 697303004316 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 697303004317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303004318 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697303004319 putative substrate translocation pore; other site 697303004320 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 697303004321 Domain of unknown function (DUF814); Region: DUF814; pfam05670 697303004322 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 697303004323 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 697303004324 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 697303004325 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 697303004326 N-Acyltransferase superfamily: Various enyzmes that characteristicly catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 697303004327 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 697303004328 MetN (also known as YusC) is an ABC-type transporter encoded by metN of the metNPQ operon in Bacillus subtilis that is involved in methionine transport. Other members of this system include the MetP permease and the MetQ substrate binding protein. ABC...; Region: ABC_MetN_methionine_transporter; cd03258 697303004329 Walker A/P-loop; other site 697303004330 ATP binding site [chemical binding]; other site 697303004331 Q-loop/lid; other site 697303004332 ABC transporter signature motif; other site 697303004333 Walker B; other site 697303004334 D-loop; other site 697303004335 H-loop/switch region; other site 697303004336 NIL domain; Region: NIL; cl09633 697303004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303004338 dimer interface [polypeptide binding]; other site 697303004339 conserved gate region; other site 697303004340 ABC-ATPase subunit interface; other site 697303004341 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 697303004342 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 697303004343 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 697303004344 Ligand Binding Site [chemical binding]; other site 697303004345 PUA domain; Region: PUA; cl00607 697303004346 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 697303004347 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303004348 S-adenosylmethionine binding site [chemical binding]; other site 697303004349 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 697303004350 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303004351 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 697303004352 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 697303004353 heterodimer interface [polypeptide binding]; other site 697303004354 active site 697303004355 FMN binding site [chemical binding]; other site 697303004356 homodimer interface [polypeptide binding]; other site 697303004357 substrate binding site [chemical binding]; other site 697303004358 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 697303004359 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 697303004360 FAD binding pocket [chemical binding]; other site 697303004361 FAD binding motif [chemical binding]; other site 697303004362 phosphate binding motif [ion binding]; other site 697303004363 beta-alpha-beta structure motif; other site 697303004364 NAD binding pocket [chemical binding]; other site 697303004365 Iron coordination center [ion binding]; other site 697303004366 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 697303004367 active site 697303004368 dimer interface [polypeptide binding]; other site 697303004369 dihydroorotase; Validated; Region: pyrC; PRK09357 697303004370 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 697303004371 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 697303004372 active site 697303004373 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 697303004374 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 697303004375 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303004376 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303004377 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypE; COG0309 697303004378 AIR synthase (PurM) related protein, subgroup 1 of unknown function. The family of PurM related proteins includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM synthase and Selenophosphate synthetase (SelD). They all contain two...; Region: PurM-like1; cd06061 697303004379 dimerization interface [polypeptide binding]; other site 697303004380 putative ATP binding site [chemical binding]; other site 697303004381 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 697303004382 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303004383 RNA binding surface [nucleotide binding]; other site 697303004384 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 697303004385 active site 697303004386 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 697303004387 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 697303004388 putative active site [active] 697303004389 Domain of unknown function (DUF2357); Region: DUF2357; pfam09823 697303004390 Protein of unknown function (DUF524); Region: DUF524; pfam04411 697303004391 Domain of unknown function (DUF3578); Region: DUF3578; pfam12102 697303004392 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 697303004393 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303004394 Walker A motif; other site 697303004395 ATP binding site [chemical binding]; other site 697303004396 Walker B motif; other site 697303004397 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 697303004398 Integrase core domain; Region: rve; cl01316 697303004399 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303004400 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303004401 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 697303004402 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 697303004403 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 697303004404 dimer interface [polypeptide binding]; other site 697303004405 FMN binding site [chemical binding]; other site 697303004406 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303004407 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303004408 DNA binding residues [nucleotide binding] 697303004409 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303004410 Uncharacterized protein involved in cytokinesis, contains TGc (transglutaminase/protease-like) domain [Cell division and chromosome partitioning]; Region: CYK3; COG5279 697303004411 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 697303004412 PspC domain; Region: PspC; cl00864 697303004413 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 697303004414 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 697303004415 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 697303004416 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 697303004417 homodimer interface [polypeptide binding]; other site 697303004418 substrate-cofactor binding pocket; other site 697303004419 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303004420 catalytic residue [active] 697303004421 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303004422 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303004423 Walker A motif; other site 697303004424 ATP binding site [chemical binding]; other site 697303004425 Walker B motif; other site 697303004426 arginine finger; other site 697303004427 Integrase core domain; Region: rve; cl01316 697303004428 IS2 transposase TnpB; Reviewed; Region: PRK09409 697303004429 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 697303004430 catalytic triad [active] 697303004431 NeuB family; Region: NeuB; cl00496 697303004432 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 697303004433 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 697303004434 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 697303004435 substrate binding site [chemical binding]; other site 697303004436 active site 697303004437 catalytic residues [active] 697303004438 heterodimer interface [polypeptide binding]; other site 697303004439 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 697303004440 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 697303004441 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303004442 catalytic residue [active] 697303004443 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric; Region: PRAI; cd00405 697303004444 active site 697303004445 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 697303004446 active site 697303004447 substrate (anthranilate) binding pocket [chemical binding]; other site 697303004448 product (indole) binding pocket [chemical binding]; other site 697303004449 ribulose/triose binding site [chemical binding]; other site 697303004450 phosphate binding site [ion binding]; other site 697303004451 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 697303004452 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 697303004453 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 697303004454 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 697303004455 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 697303004456 glutamine binding [chemical binding]; other site 697303004457 catalytic triad [active] 697303004458 anthranilate synthase component I; Provisional; Region: PRK13570 697303004459 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 697303004460 chorismate binding enzyme; Region: Chorismate_bind; cl10555 697303004461 Domain of unknown function DUF77; Region: DUF77; cl00307 697303004462 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 697303004463 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 697303004464 homodimer interface [polypeptide binding]; other site 697303004465 substrate-cofactor binding pocket; other site 697303004466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303004467 catalytic residue [active] 697303004468 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 697303004469 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 697303004470 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 697303004471 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 697303004472 intersubunit interface [polypeptide binding]; other site 697303004473 active site 697303004474 Zn2+ binding site [ion binding]; other site 697303004475 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 697303004476 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 697303004477 active site 697303004478 putative substrate binding pocket [chemical binding]; other site 697303004479 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 697303004480 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 697303004481 HIGH motif; other site 697303004482 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 697303004483 active site 697303004484 KMSKS motif; other site 697303004485 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 697303004486 tRNA binding surface [nucleotide binding]; other site 697303004487 anticodon binding site; other site 697303004488 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 697303004489 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 697303004490 DivIVA protein; Region: DivIVA; pfam05103 697303004491 DivIVA domain; Region: DivI1A_domain; TIGR03544 697303004492 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 697303004493 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303004494 RNA binding surface [nucleotide binding]; other site 697303004495 YGGT family; Region: YGGT; cl00508 697303004496 Protein of unknown function (DUF552); Region: DUF552; cl00775 697303004497 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 697303004498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697303004499 catalytic residue [active] 697303004500 HlyD family secretion protein; Region: HlyD_2; pfam12700 697303004501 putative membrane fusion protein; Region: TIGR02828 697303004502 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 697303004503 homotrimer interaction site [polypeptide binding]; other site 697303004504 putative active site [active] 697303004505 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 697303004506 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 697303004507 active site 697303004508 FMN binding site [chemical binding]; other site 697303004509 substrate binding site [chemical binding]; other site 697303004510 putative catalytic residue [active] 697303004511 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303004512 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 697303004513 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 697303004514 active site 697303004515 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 697303004516 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 697303004517 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303004518 GntP family permease; Region: GntP_permease; cl15264 697303004519 Glycerate kinase family; Region: Gly_kinase; cl00841 697303004520 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 697303004521 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 697303004522 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303004523 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 697303004524 benzoyl-CoA reductase, bzd-type, N subunit; Region: benz_CoA_bzdN; cl11464 697303004525 Domain of unknown function DUF59; Region: DUF59; cl00941 697303004526 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 697303004527 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 697303004528 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_like_3; cd09321 697303004529 gating phenylalanine in ion channel; other site 697303004530 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 697303004531 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 697303004532 4Fe-4S binding domain; Region: Fer4; cl02805 697303004533 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cl00252 697303004534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303004535 dimerization interface [polypeptide binding]; other site 697303004536 putative DNA binding site [nucleotide binding]; other site 697303004537 putative Zn2+ binding site [ion binding]; other site 697303004538 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303004539 putative substrate translocation pore; other site 697303004540 ABC-2 type transporter; Region: ABC2_membrane; cl11417 697303004541 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 697303004542 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303004543 Walker A/P-loop; other site 697303004544 ATP binding site [chemical binding]; other site 697303004545 Q-loop/lid; other site 697303004546 ABC transporter signature motif; other site 697303004547 Walker B; other site 697303004548 D-loop; other site 697303004549 H-loop/switch region; other site 697303004550 Transcriptional regulators [Transcription]; Region: MarR; COG1846 697303004551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303004552 methionine aminopeptidase; Provisional; Region: PRK12318 697303004553 SEC-C motif; Region: SEC-C; pfam02810 697303004554 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 697303004555 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303004556 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303004557 Response regulator receiver domain; Region: Response_reg; pfam00072 697303004558 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303004559 active site 697303004560 phosphorylation site [posttranslational modification] 697303004561 intermolecular recognition site; other site 697303004562 dimerization interface [polypeptide binding]; other site 697303004563 Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; cl09772 697303004564 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 697303004565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303004566 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 697303004567 Domain of unknown function (DUF205); Region: DUF205; cl00410 697303004568 GTP-binding protein Der; Reviewed; Region: PRK00093 697303004569 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA1; cd01894 697303004570 G1 box; other site 697303004571 GTP/Mg2+ binding site [chemical binding]; other site 697303004572 Switch I region; other site 697303004573 G2 box; other site 697303004574 Switch II region; other site 697303004575 G3 box; other site 697303004576 G4 box; other site 697303004577 G5 box; other site 697303004578 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an...; Region: EngA2; cd01895 697303004579 G1 box; other site 697303004580 GTP/Mg2+ binding site [chemical binding]; other site 697303004581 Switch I region; other site 697303004582 G2 box; other site 697303004583 G3 box; other site 697303004584 Switch II region; other site 697303004585 G4 box; other site 697303004586 G5 box; other site 697303004587 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 697303004588 putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279 697303004589 Protein of unknown function (DUF512); Region: DUF512; pfam04459 697303004590 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 697303004591 Protein of unknown function (DUF3189); Region: DUF3189; pfam11385 697303004592 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 697303004593 stage II sporulation protein P; Region: spore_II_P; TIGR02867 697303004594 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 697303004595 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 697303004596 PhoU domain; Region: PhoU; pfam01895 697303004597 PhoU domain; Region: PhoU; pfam01895 697303004598 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 697303004599 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 697303004600 Walker A/P-loop; other site 697303004601 ATP binding site [chemical binding]; other site 697303004602 Q-loop/lid; other site 697303004603 ABC transporter signature motif; other site 697303004604 Walker B; other site 697303004605 D-loop; other site 697303004606 H-loop/switch region; other site 697303004607 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 697303004608 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303004609 dimer interface [polypeptide binding]; other site 697303004610 conserved gate region; other site 697303004611 putative PBP binding loops; other site 697303004612 ABC-ATPase subunit interface; other site 697303004613 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 697303004614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303004615 dimer interface [polypeptide binding]; other site 697303004616 conserved gate region; other site 697303004617 putative PBP binding loops; other site 697303004618 ABC-ATPase subunit interface; other site 697303004619 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303004620 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 697303004621 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 697303004622 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303004623 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303004624 dimer interface [polypeptide binding]; other site 697303004625 phosphorylation site [posttranslational modification] 697303004626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303004627 ATP binding site [chemical binding]; other site 697303004628 Mg2+ binding site [ion binding]; other site 697303004629 G-X-G motif; other site 697303004630 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 697303004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303004632 active site 697303004633 phosphorylation site [posttranslational modification] 697303004634 intermolecular recognition site; other site 697303004635 dimerization interface [polypeptide binding]; other site 697303004636 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303004637 DNA binding site [nucleotide binding] 697303004638 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 697303004639 ATP cone domain; Region: ATP-cone; pfam03477 697303004640 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303004641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303004642 dimerization interface [polypeptide binding]; other site 697303004643 putative DNA binding site [nucleotide binding]; other site 697303004644 putative Zn2+ binding site [ion binding]; other site 697303004645 Integrase core domain; Region: rve; cl01316 697303004646 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to produce...; Region: PRCH; cl09959 697303004647 sporulation sigma factor SigG; Reviewed; Region: PRK08215 697303004648 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303004649 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697303004650 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303004651 DNA binding residues [nucleotide binding] 697303004652 sporulation sigma factor SigE; Reviewed; Region: PRK08301 697303004653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303004654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303004655 DNA binding residues [nucleotide binding] 697303004656 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 697303004657 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 697303004658 cell division protein FtsZ; Validated; Region: PRK09330 697303004659 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 697303004660 nucleotide binding site [chemical binding]; other site 697303004661 SulA interaction site; other site 697303004662 cell division protein FtsA; Region: ftsA; TIGR01174 697303004663 Cell division protein FtsA; Region: FtsA; cl11496 697303004664 Cell division protein FtsA; Region: FtsA; cl11496 697303004665 Protein of unknown function (DUF1290); Region: DUF1290; cl01587 697303004666 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 697303004667 bZIP transcription factor; Region: bZIP_1; cl02576 697303004668 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 697303004669 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 697303004670 Cell division protein FtsQ; Region: FtsQ; pfam03799 697303004671 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697303004672 3-phosphoshikimate 1-carboxyvinyltransferase; Region: aroA; TIGR01356 697303004673 hinge; other site 697303004674 active site 697303004675 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 697303004676 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 697303004677 active site 697303004678 homodimer interface [polypeptide binding]; other site 697303004679 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 697303004680 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 697303004681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303004682 NAD(P) binding pocket [chemical binding]; other site 697303004683 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303004684 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697303004685 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 697303004686 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 697303004687 Mg++ binding site [ion binding]; other site 697303004688 putative catalytic motif [active] 697303004689 putative substrate binding site [chemical binding]; other site 697303004690 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697303004691 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 697303004692 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303004693 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697303004694 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 697303004695 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697303004696 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303004697 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697303004698 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 697303004699 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697303004700 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 697303004701 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 697303004702 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 697303004703 Septum formation initiator; Region: DivIC; cl11433 697303004704 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 697303004705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303004706 cell division protein MraZ; Reviewed; Region: PRK00326 697303004707 MraZ protein; Region: MraZ; pfam02381 697303004708 MraZ protein; Region: MraZ; pfam02381 697303004709 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697303004710 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 697303004711 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697303004712 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 697303004713 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 697303004714 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 697303004715 GTP-binding protein YchF; Reviewed; Region: PRK09601 697303004716 YchF subfamily. YchF is a member of the Obg family, which includes four other subfamilies of GTPases: Obg, DRG, Ygr210, and NOG1. Obg is an essential gene that is involved in DNA replication in C. crescentus and Streptomyces griseus and is associated...; Region: YchF; cd01900 697303004717 G1 box; other site 697303004718 GTP/Mg2+ binding site [chemical binding]; other site 697303004719 Switch I region; other site 697303004720 G2 box; other site 697303004721 Switch II region; other site 697303004722 G3 box; other site 697303004723 G4 box; other site 697303004724 G5 box; other site 697303004725 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 697303004726 Protein of unknown function(DUF2089); Region: DUF2089; pfam09862 697303004727 Uncharacterized conserved protein [Function unknown]; Region: COG3595 697303004728 Protein of unknown function(DUF2089); Region: DUF2089; pfam09862 697303004729 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 697303004730 THUMP domain; Region: THUMP; cl12076 697303004731 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 697303004732 Ligand Binding Site [chemical binding]; other site 697303004733 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697303004734 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 697303004735 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303004736 catalytic residue [active] 697303004737 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 697303004738 putative homotetramer interface [polypeptide binding]; other site 697303004739 putative homodimer interface [polypeptide binding]; other site 697303004740 putative allosteric switch controlling residues; other site 697303004741 putative metal binding site [ion binding]; other site 697303004742 putative homodimer-homodimer interface [polypeptide binding]; other site 697303004743 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 697303004744 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 697303004745 putative active site [active] 697303004746 putative NTP binding site [chemical binding]; other site 697303004747 putative nucleic acid binding site [nucleotide binding]; other site 697303004748 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697303004749 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 697303004750 dinuclear metal binding motif [ion binding]; other site 697303004751 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 697303004752 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697303004753 E3 interaction surface; other site 697303004754 lipoyl attachment site [posttranslational modification]; other site 697303004755 e3 binding domain; Region: E3_binding; pfam02817 697303004756 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 697303004757 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 697303004758 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 697303004759 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 697303004760 alpha subunit interface [polypeptide binding]; other site 697303004761 TPP binding site [chemical binding]; other site 697303004762 heterodimer interface [polypeptide binding]; other site 697303004763 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303004764 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 697303004765 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 697303004766 tetramer interface [polypeptide binding]; other site 697303004767 TPP-binding site [chemical binding]; other site 697303004768 heterodimer interface [polypeptide binding]; other site 697303004769 phosphorylation loop region [posttranslational modification] 697303004770 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; cl09807 697303004771 GAF domain; Region: GAF; cl00853 697303004772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303004773 sensory histidine kinase DcuS; Provisional; Region: PRK11086 697303004774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303004775 Walker A motif; other site 697303004776 ATP binding site [chemical binding]; other site 697303004777 Walker B motif; other site 697303004778 arginine finger; other site 697303004779 lipoyl synthase; Provisional; Region: PRK05481 697303004780 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303004781 FeS/SAM binding site; other site 697303004782 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 697303004783 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 697303004784 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 697303004785 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 697303004786 oligomer interface [polypeptide binding]; other site 697303004787 Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127 697303004788 putative active site [active] 697303004789 metal binding site [ion binding]; metal-binding site 697303004790 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 697303004791 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303004792 active site 697303004793 phosphorylation site [posttranslational modification] 697303004794 intermolecular recognition site; other site 697303004795 dimerization interface [polypeptide binding]; other site 697303004796 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 697303004797 DNA binding residues [nucleotide binding] 697303004798 dimerization interface [polypeptide binding]; other site 697303004799 Sensor protein DegS; Region: DegS; pfam05384 697303004800 Histidine kinase; Region: HisKA_3; pfam07730 697303004801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303004802 ATP binding site [chemical binding]; other site 697303004803 Mg2+ binding site [ion binding]; other site 697303004804 G-X-G motif; other site 697303004805 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 697303004806 Protein of unknown function (DUF523); Region: DUF523; cl00733 697303004807 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 697303004808 MutS2 homologs in bacteria and eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also...; Region: ABC_MutS2; cd03280 697303004809 Walker A/P-loop; other site 697303004810 ATP binding site [chemical binding]; other site 697303004811 Q-loop/lid; other site 697303004812 ABC transporter signature motif; other site 697303004813 Walker B; other site 697303004814 D-loop; other site 697303004815 H-loop/switch region; other site 697303004816 Smr domain; Region: Smr; cl02619 697303004817 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 697303004818 Peptidase family U32; Region: Peptidase_U32; cl03113 697303004819 Collagenase; Region: DUF3656; pfam12392 697303004820 Peptidase family U32; Region: Peptidase_U32; cl03113 697303004821 Cell division protein ZapA; Region: ZapA; cl01146 697303004822 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 697303004823 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 697303004824 putative tRNA-binding site [nucleotide binding]; other site 697303004825 B3/4 domain; Region: B3_4; cl11458 697303004826 tRNA synthetase B5 domain; Region: B5; cl08394 697303004827 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 697303004828 dimer interface [polypeptide binding]; other site 697303004829 motif 1; other site 697303004830 motif 3; other site 697303004831 motif 2; other site 697303004832 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 697303004833 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 697303004834 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 697303004835 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 697303004836 dimer interface [polypeptide binding]; other site 697303004837 motif 1; other site 697303004838 active site 697303004839 motif 2; other site 697303004840 motif 3; other site 697303004841 Transposase domain (DUF772); Region: DUF772; cl12084 697303004842 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303004843 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 697303004844 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 697303004845 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 697303004846 ribosomal protein L20; Region: rpl20; CHL00068 697303004847 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 697303004848 23S rRNA binding site [nucleotide binding]; other site 697303004849 L21 binding site [polypeptide binding]; other site 697303004850 L13 binding site [polypeptide binding]; other site 697303004851 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 697303004852 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 697303004853 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 697303004854 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 697303004855 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303004856 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303004857 dimerization interface [polypeptide binding]; other site 697303004858 putative DNA binding site [nucleotide binding]; other site 697303004859 putative Zn2+ binding site [ion binding]; other site 697303004860 Integrase core domain; Region: rve; cl01316 697303004861 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 697303004862 Tetramer interface [polypeptide binding]; other site 697303004863 active site 697303004864 FMN-binding site [chemical binding]; other site 697303004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303004866 putative substrate translocation pore; other site 697303004867 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 697303004868 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 697303004869 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 697303004870 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 697303004871 active site 697303004872 dimer interface [polypeptide binding]; other site 697303004873 motif 1; other site 697303004874 motif 2; other site 697303004875 motif 3; other site 697303004876 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 697303004877 anticodon binding site; other site 697303004878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4399 697303004879 Protein of unknown function (DUF445); Region: DUF445; pfam04286 697303004880 YtxC-like family; Region: YtxC; cl08500 697303004881 Response regulator receiver domain; Region: Response_reg; pfam00072 697303004882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303004883 active site 697303004884 phosphorylation site [posttranslational modification] 697303004885 intermolecular recognition site; other site 697303004886 dimerization interface [polypeptide binding]; other site 697303004887 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303004888 metal binding site [ion binding]; metal-binding site 697303004889 active site 697303004890 I-site; other site 697303004891 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697303004892 catalytic residues [active] 697303004893 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 697303004894 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 697303004895 dimerization interface [polypeptide binding]; other site 697303004896 domain crossover interface; other site 697303004897 redox-dependent activation switch; other site 697303004898 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein; Region: CSP_CDS; cd04458 697303004899 DNA-binding site [nucleotide binding]; DNA binding site 697303004900 RNA-binding motif; other site 697303004901 NAD-dependent deacetylase; Provisional; Region: PRK14138 697303004902 SIR2_Af2: Archaeal and prokaryotic group which includes Archaeoglobus fulgidus Sir2-Af2, Sulfolobus solfataricus ssSir2, and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2_Af2; cd01413 697303004903 NAD+ binding site [chemical binding]; other site 697303004904 substrate binding site [chemical binding]; other site 697303004905 Zn binding site [ion binding]; other site 697303004906 NifU-like domain; Region: NifU; cl00484 697303004907 GAF domain; Region: GAF; cl00853 697303004908 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 697303004909 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 697303004910 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 697303004911 metal binding site [ion binding]; metal-binding site 697303004912 dipeptidase PepV; Reviewed; Region: PRK07318 697303004913 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 697303004914 active site 697303004915 metal binding site [ion binding]; metal-binding site 697303004916 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 697303004917 Glyco_18 domain; Region: Glyco_18; smart00636 697303004918 active site 697303004919 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 697303004920 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 697303004921 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 697303004922 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 697303004923 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 697303004924 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 697303004925 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 697303004926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303004927 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 697303004928 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 697303004929 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 697303004930 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303004931 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 697303004932 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303004933 DNA binding residues [nucleotide binding] 697303004934 DNA primase; Validated; Region: dnaG; PRK05667 697303004935 CHC2 zinc finger; Region: zf-CHC2; cl15369 697303004936 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 697303004937 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 697303004938 active site 697303004939 metal binding site [ion binding]; metal-binding site 697303004940 interdomain interaction site; other site 697303004941 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 697303004942 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303004943 Zn2+ binding site [ion binding]; other site 697303004944 Mg2+ binding site [ion binding]; other site 697303004945 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303004946 Preprotein translocase SecG subunit; Region: SecG; cl09123 697303004947 enolase; Provisional; Region: eno; PRK00077 697303004948 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 697303004949 dimer interface [polypeptide binding]; other site 697303004950 metal binding site [ion binding]; metal-binding site 697303004951 substrate binding pocket [chemical binding]; other site 697303004952 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 697303004953 Sulfatase; Region: Sulfatase; cl10460 697303004954 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 697303004955 substrate binding site [chemical binding]; other site 697303004956 dimer interface [polypeptide binding]; other site 697303004957 catalytic triad [active] 697303004958 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 697303004959 substrate binding site [chemical binding]; other site 697303004960 hinge regions; other site 697303004961 ADP binding site [chemical binding]; other site 697303004962 catalytic site [active] 697303004963 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 697303004964 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 697303004965 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 697303004966 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 697303004967 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 697303004968 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 697303004969 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 697303004970 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 697303004971 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 697303004972 Acylphosphatase; Region: Acylphosphatase; cl00551 697303004973 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303004974 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 697303004975 active site 697303004976 motif I; other site 697303004977 motif II; other site 697303004978 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303004979 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303004980 Transposase domain (DUF772); Region: DUF772; cl12084 697303004981 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303004982 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697303004983 metal binding site 2 [ion binding]; metal-binding site 697303004984 putative DNA binding helix; other site 697303004985 metal binding site 1 [ion binding]; metal-binding site 697303004986 dimer interface [polypeptide binding]; other site 697303004987 structural Zn2+ binding site [ion binding]; other site 697303004988 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 697303004989 VanW like protein; Region: VanW; pfam04294 697303004990 G5 domain; Region: G5; pfam07501 697303004991 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 697303004992 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 697303004993 minor groove reading motif; other site 697303004994 helix-hairpin-helix signature motif; other site 697303004995 active site 697303004996 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 697303004997 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 697303004998 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 697303004999 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 697303005000 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 697303005001 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697303005002 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 697303005003 4Fe-4S binding domain; Region: Fer4; cl02805 697303005004 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005005 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303005006 FeS/SAM binding site; other site 697303005007 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 697303005008 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303005009 dimerization interface [polypeptide binding]; other site 697303005010 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303005011 Cache domain; Region: Cache_1; pfam02743 697303005012 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 697303005013 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 697303005014 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 697303005015 Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028 697303005016 active site 697303005017 Transposase domain (DUF772); Region: DUF772; cl12084 697303005018 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303005019 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303005020 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697303005021 MULE transposase domain; Region: MULE; pfam10551 697303005022 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303005023 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303005024 dimerization interface [polypeptide binding]; other site 697303005025 putative DNA binding site [nucleotide binding]; other site 697303005026 putative Zn2+ binding site [ion binding]; other site 697303005027 Integrase core domain; Region: rve; cl01316 697303005028 Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299 697303005029 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303005030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303005031 Walker A motif; other site 697303005032 ATP binding site [chemical binding]; other site 697303005033 Walker B motif; other site 697303005034 arginine finger; other site 697303005035 Protein of unknown function (DUF1646); Region: DUF1646; pfam07854 697303005036 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 697303005037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 697303005038 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697303005039 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303005040 motif II; other site 697303005041 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 697303005042 nitrogenase reductase; Reviewed; Region: nifH; PRK13233 697303005043 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 697303005044 Altronate dehydratase [Carbohydrate transport and metabolism]; Region: UxaA; COG2721 697303005045 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 697303005046 SAF domain; Region: SAF; cl00555 697303005047 Dehydratase family; Region: ILVD_EDD; cl00340 697303005048 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 697303005049 N- and C-terminal domain interface [polypeptide binding]; other site 697303005050 MgATP binding site [chemical binding]; other site 697303005051 active site 697303005052 catalytic site [active] 697303005053 metal binding site [ion binding]; metal-binding site 697303005054 carbohydrate binding site [chemical binding]; other site 697303005055 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 697303005056 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 697303005057 inhibitor site; inhibition site 697303005058 active site 697303005059 dimer interface [polypeptide binding]; other site 697303005060 catalytic residue [active] 697303005061 Transposase domain (DUF772); Region: DUF772; cl12084 697303005062 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303005063 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 697303005064 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005065 Uncharacterized conserved protein [Function unknown]; Region: COG2006 697303005066 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 697303005067 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005068 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 697303005069 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 697303005070 inhibitor site; inhibition site 697303005071 active site 697303005072 dimer interface [polypeptide binding]; other site 697303005073 catalytic residue [active] 697303005074 hypothetical protein; Provisional; Region: PRK08185 697303005075 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697303005076 intersubunit interface [polypeptide binding]; other site 697303005077 active site 697303005078 zinc binding site [ion binding]; other site 697303005079 Na+ binding site [ion binding]; other site 697303005080 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 697303005081 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303005082 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 697303005083 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303005084 motif I; other site 697303005085 active site 697303005086 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303005087 motif II; other site 697303005088 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 697303005089 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 697303005090 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697303005091 PYR/PP interface [polypeptide binding]; other site 697303005092 dimer interface [polypeptide binding]; other site 697303005093 TPP binding site [chemical binding]; other site 697303005094 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303005095 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 697303005096 TPP-binding site [chemical binding]; other site 697303005097 dimer interface [polypeptide binding]; other site 697303005098 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 697303005099 catalytic residue [active] 697303005100 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 697303005101 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303005102 Walker A motif; other site 697303005103 ATP binding site [chemical binding]; other site 697303005104 Walker B motif; other site 697303005105 arginine finger; other site 697303005106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005107 Radical SAM superfamily; Region: Radical_SAM; pfam04055 697303005108 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303005109 FeS/SAM binding site; other site 697303005110 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 697303005111 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF and...; Region: PseudoU_synth_RluCD_like; cd02869 697303005112 active site 697303005113 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 697303005114 nudix motif; other site 697303005115 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 697303005116 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 697303005117 active site 697303005118 substrate-binding site [chemical binding]; other site 697303005119 metal-binding site [ion binding] 697303005120 ATP binding site [chemical binding]; other site 697303005121 recombination factor protein RarA; Reviewed; Region: PRK13342 697303005122 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303005123 Walker A motif; other site 697303005124 ATP binding site [chemical binding]; other site 697303005125 Walker B motif; other site 697303005126 arginine finger; other site 697303005127 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 697303005128 HIRAN domain; Region: HIRAN; cl07418 697303005129 Domain of unknown function (DUF205); Region: DUF205; cl00410 697303005130 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 697303005131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 697303005132 active site 697303005133 Uncharacterized conserved protein [Function unknown]; Region: COG2128 697303005134 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 697303005135 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 697303005136 active site 697303005137 nucleophile elbow; other site 697303005138 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 697303005139 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303005140 S-adenosylmethionine binding site [chemical binding]; other site 697303005141 HutP; Region: HutP; cl07944 697303005142 subunit; Region: OAD_beta; cl00816 697303005143 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 697303005144 CotJB protein; Region: CotJB; pfam12652 697303005145 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 697303005146 dimanganese center [ion binding]; other site 697303005147 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 697303005148 putative deacylase active site [active] 697303005149 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 697303005150 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 697303005151 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 697303005152 Pterin binding enzyme; Region: Pterin_bind; pfam00809 697303005153 substrate binding pocket [chemical binding]; other site 697303005154 dimer interface [polypeptide binding]; other site 697303005155 inhibitor binding site; inhibition site 697303005156 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 697303005157 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 697303005158 B12 binding site [chemical binding]; other site 697303005159 cobalt ligand [ion binding]; other site 697303005160 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 697303005161 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 697303005162 FAD binding site [chemical binding]; other site 697303005163 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 697303005164 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 697303005165 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 697303005166 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 697303005167 active site 697303005168 dimer interface [polypeptide binding]; other site 697303005169 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 697303005170 dimer interface [polypeptide binding]; other site 697303005171 active site 697303005172 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150 697303005173 putative FMN binding site [chemical binding]; other site 697303005174 peptidase T; Region: peptidase-T; TIGR01882 697303005175 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 697303005176 metal binding site [ion binding]; metal-binding site 697303005177 dimer interface [polypeptide binding]; other site 697303005178 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 697303005179 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303005180 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 697303005181 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 697303005182 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 697303005183 active site 697303005184 catalytic residues [active] 697303005185 metal binding site [ion binding]; metal-binding site 697303005186 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 697303005187 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 697303005188 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 697303005189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303005190 dimer interface [polypeptide binding]; other site 697303005191 conserved gate region; other site 697303005192 ABC-ATPase subunit interface; other site 697303005193 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 697303005194 OpuCA is a the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing in a hyperosmolar environment. ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of...; Region: ABC_OpuCA_Osmoprotection; cd03295 697303005195 Walker A/P-loop; other site 697303005196 ATP binding site [chemical binding]; other site 697303005197 Q-loop/lid; other site 697303005198 ABC transporter signature motif; other site 697303005199 Walker B; other site 697303005200 D-loop; other site 697303005201 H-loop/switch region; other site 697303005202 FOG: CBS domain [General function prediction only]; Region: COG0517 697303005203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 697303005204 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303005205 DNA-binding site [nucleotide binding]; DNA binding site 697303005206 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 697303005207 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 697303005208 MatE; Region: MatE; cl10513 697303005209 MatE; Region: MatE; cl10513 697303005210 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 697303005211 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 697303005212 ligand binding site [chemical binding]; other site 697303005213 flexible hinge region; other site 697303005214 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 697303005215 putative switch regulator; other site 697303005216 non-specific DNA interactions [nucleotide binding]; other site 697303005217 DNA binding site [nucleotide binding] 697303005218 sequence specific DNA binding site [nucleotide binding]; other site 697303005219 putative cAMP binding site [chemical binding]; other site 697303005220 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 697303005221 TRAM domain; Region: TRAM; cl01282 697303005222 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 697303005223 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697303005224 active site 697303005225 ATP binding site [chemical binding]; other site 697303005226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303005227 S-adenosylmethionine binding site [chemical binding]; other site 697303005228 activation loop (A-loop); other site 697303005229 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 697303005230 active site 697303005231 pyruvate kinase; Provisional; Region: PRK06354 697303005232 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 697303005233 domain interfaces; other site 697303005234 active site 697303005235 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 697303005236 6-phosphofructokinase; Provisional; Region: PRK03202 697303005237 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 697303005238 active site 697303005239 ADP/pyrophosphate binding site [chemical binding]; other site 697303005240 dimerization interface [polypeptide binding]; other site 697303005241 allosteric effector site; other site 697303005242 fructose-1,6-bisphosphate binding site; other site 697303005243 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 697303005244 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303005245 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 697303005246 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 697303005247 generic binding surface II; other site 697303005248 generic binding surface I; other site 697303005249 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 697303005250 DRTGG domain; Region: DRTGG; cl12147 697303005251 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 697303005252 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 697303005253 active site 2 [active] 697303005254 active site 1 [active] 697303005255 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 697303005256 dimerization domain swap beta strand [polypeptide binding]; other site 697303005257 regulatory protein interface [polypeptide binding]; other site 697303005258 active site 697303005259 regulatory phosphorylation site [posttranslational modification]; other site 697303005260 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 697303005261 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 697303005262 maltodextrin glucosidase; Provisional; Region: PRK10785 697303005263 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 697303005264 homodimer interface [polypeptide binding]; other site 697303005265 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 697303005266 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 697303005267 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 697303005269 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 697303005270 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 697303005271 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 697303005272 ABC-type maltose transport systems, permease component [Carbohydrate transport and metabolism]; Region: MalG; COG3833 697303005273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303005274 dimer interface [polypeptide binding]; other site 697303005275 conserved gate region; other site 697303005276 putative PBP binding loops; other site 697303005277 ABC-ATPase subunit interface; other site 697303005278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303005279 dimer interface [polypeptide binding]; other site 697303005280 conserved gate region; other site 697303005281 ABC-ATPase subunit interface; other site 697303005282 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 697303005283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303005284 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 697303005285 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 697303005286 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 697303005287 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 697303005288 Uncharacterised protein family UPF0052; Region: UPF0052; pfam01933 697303005289 phosphate binding site [ion binding]; other site 697303005290 putative substrate binding pocket [chemical binding]; other site 697303005291 dimer interface [polypeptide binding]; other site 697303005292 Predicted P-loop-containing kinase [General function prediction only]; Region: COG1660 697303005293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303005294 Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387 697303005295 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303005296 RNase P subunit p30; Region: RNase_P_p30; cl03389 697303005297 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 697303005298 FAD binding domain; Region: FAD_binding_4; pfam01565 697303005299 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 697303005300 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 697303005301 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 697303005302 active site 697303005303 nucleophile elbow; other site 697303005304 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 697303005305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005306 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 697303005307 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697303005308 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: APH_ChoK_like; cd05120 697303005309 active site 697303005310 ATP binding site [chemical binding]; other site 697303005311 Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863 697303005312 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 697303005313 catalytic triad [active] 697303005314 conserved cis-peptide bond; other site 697303005315 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 697303005316 metal-binding site [ion binding] 697303005317 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 697303005318 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 697303005319 metal-binding site [ion binding] 697303005320 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697303005321 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303005322 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 697303005323 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 697303005324 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697303005325 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 697303005326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303005327 catalytic residue [active] 697303005328 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 697303005329 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 697303005330 dimer interface [polypeptide binding]; other site 697303005331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303005332 catalytic residue [active] 697303005333 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 697303005334 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 697303005335 metal-binding site [ion binding] 697303005336 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 697303005337 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 697303005338 Predicted membrane protein [Function unknown]; Region: COG4267 697303005339 PAS domain S-box; Region: sensory_box; TIGR00229 697303005340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303005341 putative active site [active] 697303005342 heme pocket [chemical binding]; other site 697303005343 PAS domain S-box; Region: sensory_box; TIGR00229 697303005344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303005345 putative active site [active] 697303005346 heme pocket [chemical binding]; other site 697303005347 PAS domain S-box; Region: sensory_box; TIGR00229 697303005348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303005349 metal binding site [ion binding]; metal-binding site 697303005350 active site 697303005351 I-site; other site 697303005352 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303005353 Zn2+ binding site [ion binding]; other site 697303005354 Mg2+ binding site [ion binding]; other site 697303005355 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 697303005356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303005357 FeS/SAM binding site; other site 697303005358 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 697303005359 ATP cone domain; Region: ATP-cone; pfam03477 697303005360 Class III ribonucleotide reductase; Region: RNR_III; cd01675 697303005361 effector binding site; other site 697303005362 active site 697303005363 Zn binding site [ion binding]; other site 697303005364 glycine loop; other site 697303005365 The Phox Homology domain, a phosphoinositide binding module; Region: PX_domain; cl02563 697303005366 phosphoinositide binding site [chemical binding]; other site 697303005367 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 697303005368 metal binding site 2 [ion binding]; metal-binding site 697303005369 putative DNA binding helix; other site 697303005370 metal binding site 1 [ion binding]; metal-binding site 697303005371 dimer interface [polypeptide binding]; other site 697303005372 structural Zn2+ binding site [ion binding]; other site 697303005373 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 697303005374 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 697303005375 G1 box; other site 697303005376 GTP/Mg2+ binding site [chemical binding]; other site 697303005377 Switch I region; other site 697303005378 G2 box; other site 697303005379 G3 box; other site 697303005380 Switch II region; other site 697303005381 G4 box; other site 697303005382 G5 box; other site 697303005383 Nucleoside recognition; Region: Gate; cl00486 697303005384 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 697303005385 Nucleoside recognition; Region: Gate; cl00486 697303005386 FeoA domain; Region: FeoA; cl00838 697303005387 FeoA domain; Region: FeoA; cl00838 697303005388 Protein of unknown function (DUF1847); Region: DUF1847; cl02037 697303005389 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 697303005390 homodimer interaction site [polypeptide binding]; other site 697303005391 cofactor binding site; other site 697303005392 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 697303005393 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 697303005394 Walker A/P-loop; other site 697303005395 ATP binding site [chemical binding]; other site 697303005396 Q-loop/lid; other site 697303005397 ABC transporter signature motif; other site 697303005398 Walker B; other site 697303005399 D-loop; other site 697303005400 H-loop/switch region; other site 697303005401 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 697303005402 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 697303005403 ABC-ATPase subunit interface; other site 697303005404 dimer interface [polypeptide binding]; other site 697303005405 putative PBP binding regions; other site 697303005406 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 697303005407 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 697303005408 putative metal binding site [ion binding]; other site 697303005409 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 697303005410 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303005411 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303005412 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 697303005413 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005414 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697303005415 biotin synthase; Provisional; Region: PRK07094 697303005416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303005417 FeS/SAM binding site; other site 697303005418 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 697303005419 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 697303005420 NADH dehydrogenase subunit I; Region: ndhI; CHL00014 697303005421 4Fe-4S binding domain; Region: Fer4; cl02805 697303005422 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 697303005423 4Fe-4S binding domain; Region: Fer4; cl02805 697303005424 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme. This...; Region: NifX_NifB; cd00562 697303005425 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303005426 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 697303005427 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 697303005428 Ferredoxin [Energy production and conversion]; Region: COG1146 697303005429 switch II; other site 697303005430 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 697303005431 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 697303005432 switch II; other site 697303005433 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 697303005434 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 697303005435 G1 box; other site 697303005436 GTP/Mg2+ binding site [chemical binding]; other site 697303005437 Switch I region; other site 697303005438 G2 box; other site 697303005439 Switch II region; other site 697303005440 G3 box; other site 697303005441 G4 box; other site 697303005442 G5 box; other site 697303005443 ATP-dependent protease La; Region: lon; TIGR00763 697303005444 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 697303005445 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303005446 S-adenosylmethionine binding site [chemical binding]; other site 697303005447 Predicted methyltransferases [General function prediction only]; Region: COG1568 697303005448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303005449 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303005450 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303005451 DNA binding site [nucleotide binding] 697303005452 domain linker motif; other site 697303005453 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 697303005454 dimerization interface [polypeptide binding]; other site 697303005455 ligand binding site [chemical binding]; other site 697303005456 sodium binding site [ion binding]; other site 697303005457 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 697303005458 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 697303005459 putative substrate binding site [chemical binding]; other site 697303005460 putative ATP binding site [chemical binding]; other site 697303005461 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 697303005462 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 697303005463 substrate binding [chemical binding]; other site 697303005464 active site 697303005465 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 697303005466 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697303005467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303005468 dimer interface [polypeptide binding]; other site 697303005469 conserved gate region; other site 697303005470 putative PBP binding loops; other site 697303005471 ABC-ATPase subunit interface; other site 697303005472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303005473 dimer interface [polypeptide binding]; other site 697303005474 conserved gate region; other site 697303005475 putative PBP binding loops; other site 697303005476 ABC-ATPase subunit interface; other site 697303005477 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697303005478 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303005479 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303005480 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697303005481 putative substrate translocation pore; other site 697303005482 Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571 697303005483 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 697303005484 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 697303005485 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697303005486 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 697303005487 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303005488 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 697303005489 active site 697303005490 intersubunit interactions; other site 697303005491 catalytic residue [active] 697303005492 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303005493 Walker A motif; other site 697303005494 ATP binding site [chemical binding]; other site 697303005495 Walker B motif; other site 697303005496 arginine finger; other site 697303005497 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 697303005498 active site 697303005499 dimerization interface [polypeptide binding]; other site 697303005500 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 697303005501 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 697303005502 active site 697303005503 metal binding site [ion binding]; metal-binding site 697303005504 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 697303005505 Amino acid permease; Region: AA_permease; cl00524 697303005506 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 697303005507 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005508 NAD(P) binding site [chemical binding]; other site 697303005509 active site 697303005510 uncharacterized xylulose kinase-like proteins, subgroup 1; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804 697303005511 N- and C-terminal domain interface [polypeptide binding]; other site 697303005512 D-xylulose kinase; Region: XylB; TIGR01312 697303005513 putative active site [active] 697303005514 catalytic site [active] 697303005515 metal binding site [ion binding]; metal-binding site 697303005516 putative xylulose binding site [chemical binding]; other site 697303005517 putative ATP binding site [chemical binding]; other site 697303005518 putative homodimer interface [polypeptide binding]; other site 697303005519 BtpA family; Region: BtpA; cl00440 697303005520 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697303005521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005522 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 697303005523 Archaeal ATPase; Region: Arch_ATPase; pfam01637 697303005524 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 697303005525 SEC-C motif; Region: SEC-C; pfam02810 697303005526 Uncharacterized conserved protein [Function unknown]; Region: COG4715 697303005527 SWIM zinc finger; Region: SWIM; cl15408 697303005528 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 697303005529 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303005530 flagellar capping protein; Reviewed; Region: fliD; PRK08032 697303005531 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 697303005532 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 697303005533 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 697303005534 ABC-2 type transporter; Region: ABC2_membrane; cl11417 697303005535 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 697303005536 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303005537 Walker A/P-loop; other site 697303005538 ATP binding site [chemical binding]; other site 697303005539 Q-loop/lid; other site 697303005540 ABC transporter signature motif; other site 697303005541 Walker B; other site 697303005542 D-loop; other site 697303005543 H-loop/switch region; other site 697303005544 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 697303005545 Acetamidase/Formamidase family; Region: FmdA_AmdA; cl01023 697303005546 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 697303005547 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 697303005548 domain; Region: Glyco_hydro_2; pfam00703 697303005549 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 697303005550 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 697303005551 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 697303005552 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303005553 dimer interface [polypeptide binding]; other site 697303005554 conserved gate region; other site 697303005555 putative PBP binding loops; other site 697303005556 ABC-ATPase subunit interface; other site 697303005557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303005558 dimer interface [polypeptide binding]; other site 697303005559 conserved gate region; other site 697303005560 putative PBP binding loops; other site 697303005561 ABC-ATPase subunit interface; other site 697303005562 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 697303005563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 697303005564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005565 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 697303005566 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303005567 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 697303005568 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 697303005569 NAD binding site [chemical binding]; other site 697303005570 homodimer interface [polypeptide binding]; other site 697303005571 active site 697303005572 substrate binding site [chemical binding]; other site 697303005573 galactokinase; Provisional; Region: PRK05322 697303005574 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 697303005575 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 697303005576 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697303005577 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 697303005578 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 697303005579 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 697303005580 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 697303005581 putative active site [active] 697303005582 Entner-Doudoroff aldolase; Region: eda; TIGR01182 697303005583 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 697303005584 active site 697303005585 intersubunit interface [polypeptide binding]; other site 697303005586 catalytic residue [active] 697303005587 glyoxylate reductase; Reviewed; Region: PRK13243 697303005588 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005589 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 697303005590 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 697303005591 active site 697303005592 phosphorylation site [posttranslational modification] 697303005593 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303005594 active pocket/dimerization site; other site 697303005595 active site 697303005596 phosphorylation site [posttranslational modification] 697303005597 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 697303005598 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 697303005599 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 697303005600 active site 697303005601 phosphorylation site [posttranslational modification] 697303005602 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303005603 active pocket/dimerization site; other site 697303005604 active site 697303005605 phosphorylation site [posttranslational modification] 697303005606 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 697303005607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303005608 Walker A motif; other site 697303005609 ATP binding site [chemical binding]; other site 697303005610 Walker B motif; other site 697303005611 arginine finger; other site 697303005612 PRD domain; Region: PRD; cl15445 697303005613 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303005614 active pocket/dimerization site; other site 697303005615 active site 697303005616 phosphorylation site [posttranslational modification] 697303005617 PRD domain; Region: PRD; cl15445 697303005618 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005619 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 697303005620 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 697303005621 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 697303005622 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005623 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697303005624 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303005625 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 697303005626 glyoxylate reductase; Reviewed; Region: PRK13243 697303005627 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005628 Membrane transport protein; Region: Mem_trans; cl09117 697303005629 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 697303005630 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 697303005631 AP (apurinic/apyrimidinic) site pocket; other site 697303005632 DNA interaction; other site 697303005633 Metal-binding active site; metal-binding site 697303005634 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 697303005635 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 697303005636 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697303005637 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005638 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 697303005639 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697303005640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005641 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 697303005642 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303005643 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303005644 DNA binding site [nucleotide binding] 697303005645 domain linker motif; other site 697303005646 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 697303005647 dimerization interface [polypeptide binding]; other site 697303005648 ligand binding site [chemical binding]; other site 697303005649 YcfA-like protein; Region: YcfA; cl00752 697303005650 Phd_YefM; Region: PhdYeFM; cl09153 697303005651 Protein of unknown function (DUF3832); Region: DUF3832; pfam12909 697303005652 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 697303005653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303005654 FeS/SAM binding site; other site 697303005655 hypothetical protein; Provisional; Region: PRK03881 697303005656 The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951 697303005657 AMMECR1; Region: AMMECR1; cl00911 697303005658 Protein of unknown function, DUF624; Region: DUF624; cl02369 697303005659 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 697303005660 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 697303005661 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 697303005662 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 697303005663 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 697303005664 catalytic site [active] 697303005665 metal binding site [ion binding]; metal-binding site 697303005666 putative hydrolase; Validated; Region: PRK09248 697303005667 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303005668 Ribosomal_L32_L32e: L32 is a protein from the large subunit that contains a surface-exposed globular domain and a finger-like projection that extends into the RNA core to stabilize the tertiary structure. L32 does not appear to play a role in forming the...; Region: Ribosomal_L32_L32e; cl00748 697303005669 HPr kinase/phosphorylase; Provisional; Region: PRK05428 697303005670 DRTGG domain; Region: DRTGG; cl12147 697303005671 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 697303005672 Hpr binding site; other site 697303005673 active site 697303005674 homohexamer subunit interaction site [polypeptide binding]; other site 697303005675 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005676 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 697303005677 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 697303005678 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 697303005679 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 697303005680 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 697303005681 GIY-YIG motif/motif A; other site 697303005682 active site 697303005683 catalytic site [active] 697303005684 putative DNA binding site [nucleotide binding]; other site 697303005685 metal binding site [ion binding]; metal-binding site 697303005686 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 697303005687 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 697303005688 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 697303005689 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01009 697303005690 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 697303005691 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 697303005692 phosphopeptide binding site; other site 697303005693 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 697303005694 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 697303005695 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 697303005696 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 697303005697 excinuclease ABC subunit B; Provisional; Region: PRK05298 697303005698 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 697303005699 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697303005700 ATP-binding site [chemical binding]; other site 697303005701 ATP binding site [chemical binding]; other site 697303005702 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697303005703 nucleotide binding region [chemical binding]; other site 697303005704 ATP-binding site [chemical binding]; other site 697303005705 Ultra-violet resistance protein B; Region: UvrB; pfam12344 697303005706 UvrB/uvrC motif; Region: UVR; pfam02151 697303005707 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 697303005708 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 697303005709 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697303005710 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 697303005711 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 697303005712 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 697303005713 protein binding site [polypeptide binding]; other site 697303005714 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 697303005715 Catalytic dyad [active] 697303005716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 697303005717 Peptidase family M23; Region: Peptidase_M23; pfam01551 697303005718 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 697303005719 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 697303005720 FtsE is a hydrophilic nucleotide-binding protein that binds FtsX to form a heterodimeric ATP-binding cassette (ABC)-type transporter that associates with the bacterial inner membrane. The FtsE/X transporter is thought to be involved in cell division and...; Region: ABC_FtsE_transporter; cd03292 697303005721 Walker A/P-loop; other site 697303005722 ATP binding site [chemical binding]; other site 697303005723 Q-loop/lid; other site 697303005724 ABC transporter signature motif; other site 697303005725 Walker B; other site 697303005726 D-loop; other site 697303005727 H-loop/switch region; other site 697303005728 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 697303005729 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 697303005730 The N-terminal ATPase domain of the maltose transporter, MalK. ATP binding cassette (ABC) proteins function from bacteria to human, mediating the translocation of substances into and out of cells or organelles. ABC transporters contain two...; Region: ABC_MalK_N; cd03301 697303005731 Walker A/P-loop; other site 697303005732 ATP binding site [chemical binding]; other site 697303005733 Q-loop/lid; other site 697303005734 ABC transporter signature motif; other site 697303005735 Walker B; other site 697303005736 D-loop; other site 697303005737 H-loop/switch region; other site 697303005738 diaminopimelate decarboxylase; Region: lysA; TIGR01048 697303005739 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 697303005740 active site 697303005741 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697303005742 substrate binding site [chemical binding]; other site 697303005743 catalytic residues [active] 697303005744 dimer interface [polypeptide binding]; other site 697303005745 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 697303005746 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 697303005747 5S rRNA interface [nucleotide binding]; other site 697303005748 CTC domain interface [polypeptide binding]; other site 697303005749 L16 interface [polypeptide binding]; other site 697303005750 RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468 697303005751 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303005752 Walker A motif; other site 697303005753 ATP binding site [chemical binding]; other site 697303005754 Walker B motif; other site 697303005755 PspC domain; Region: PspC; cl00864 697303005756 Phd_YefM; Region: PhdYeFM; cl09153 697303005757 Sporulation and spore germination; Region: Germane; cl11253 697303005758 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303005759 Transposase domain (DUF772); Region: DUF772; cl12084 697303005760 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303005761 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 697303005762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697303005763 Coenzyme A binding pocket [chemical binding]; other site 697303005764 H+ Antiporter protein; Region: 2A0121; TIGR00900 697303005765 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 697303005766 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697303005767 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 697303005768 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 697303005769 4Fe-4S binding domain; Region: Fer4; cl02805 697303005770 4Fe-4S binding domain; Region: Fer4; cl02805 697303005771 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 697303005772 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 697303005773 Putative Fe-S cluster; Region: FeS; pfam04060 697303005774 PAS domain S-box; Region: sensory_box; TIGR00229 697303005775 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303005776 putative active site [active] 697303005777 heme pocket [chemical binding]; other site 697303005778 Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186 697303005779 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 697303005780 putative active site [active] 697303005781 metal binding site [ion binding]; metal-binding site 697303005782 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 697303005783 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 697303005784 tetramer interface [polypeptide binding]; other site 697303005785 catalytic Zn binding site [ion binding]; other site 697303005786 NADP binding site [chemical binding]; other site 697303005787 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 697303005788 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 697303005789 FAD binding pocket [chemical binding]; other site 697303005790 FAD binding motif [chemical binding]; other site 697303005791 phosphate binding motif [ion binding]; other site 697303005792 beta-alpha-beta structure motif; other site 697303005793 NAD binding pocket [chemical binding]; other site 697303005794 Iron coordination center [ion binding]; other site 697303005795 putative oxidoreductase; Provisional; Region: PRK12831 697303005796 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005797 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005798 archaeoflavoprotein, MJ0208 family; Region: flavo_MJ0208; TIGR02700 697303005799 4Fe-4S binding domain; Region: Fer4; cl02805 697303005800 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 697303005801 4Fe-4S binding domain; Region: Fer4; cl02805 697303005802 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 697303005803 Archaeal ATPase; Region: Arch_ATPase; pfam01637 697303005804 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 697303005805 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303005806 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 697303005807 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303005808 motif II; other site 697303005809 cell division protein FtsA; Region: ftsA; TIGR01174 697303005810 Cell division protein FtsA; Region: FtsA; cl11496 697303005811 Cell division protein FtsA; Region: FtsA; cl11496 697303005812 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 697303005813 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 697303005814 peptide binding site [polypeptide binding]; other site 697303005815 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 697303005816 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303005817 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697303005818 Walker A motif; other site 697303005819 ATP binding site [chemical binding]; other site 697303005820 Walker B motif; other site 697303005821 arginine finger; other site 697303005822 Peptidase family M41; Region: Peptidase_M41; pfam01434 697303005823 Protein of unknown function (DUF1461); Region: DUF1461; cl01862 697303005824 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 697303005825 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 697303005826 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 697303005827 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303005828 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 697303005829 DAK2 domain; Region: Dak2; cl03685 697303005830 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 697303005831 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 697303005832 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 697303005833 dimerization domain swap beta strand [polypeptide binding]; other site 697303005834 regulatory protein interface [polypeptide binding]; other site 697303005835 active site 697303005836 regulatory phosphorylation site [posttranslational modification]; other site 697303005837 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 697303005838 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303005839 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303005840 Walker A motif; other site 697303005841 ATP binding site [chemical binding]; other site 697303005842 Walker B motif; other site 697303005843 arginine finger; other site 697303005844 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 697303005845 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 697303005846 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 697303005847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005848 Predicted dehydrogenase [General function prediction only]; Region: COG0579 697303005849 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005850 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 697303005851 glycerol kinase; Provisional; Region: glpK; PRK00047 697303005852 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 697303005853 N- and C-terminal domain interface [polypeptide binding]; other site 697303005854 active site 697303005855 MgATP binding site [chemical binding]; other site 697303005856 catalytic site [active] 697303005857 metal binding site [ion binding]; metal-binding site 697303005858 glycerol binding site [chemical binding]; other site 697303005859 homotetramer interface [polypeptide binding]; other site 697303005860 homodimer interface [polypeptide binding]; other site 697303005861 FBP binding site [chemical binding]; other site 697303005862 protein IIAGlc interface [polypeptide binding]; other site 697303005863 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 697303005864 amphipathic channel; other site 697303005865 Asn-Pro-Ala signature motifs; other site 697303005866 Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852 697303005867 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 697303005868 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 697303005869 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 697303005870 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 697303005871 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 697303005872 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 697303005873 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 697303005874 Ligand Binding Site [chemical binding]; other site 697303005875 K+-transporting ATPase, c chain; Region: KdpC; cl00944 697303005876 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 697303005877 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697303005878 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303005879 Potassium-transporting ATPase A subunit; Region: KdpA; cl00903 697303005880 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 697303005881 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 697303005882 active site 697303005883 Substrate binding site; other site 697303005884 Mg++ binding site; other site 697303005885 Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the...; Region: LbH_G1P_AT_C_like; cd03356 697303005886 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 697303005887 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 697303005888 active site 697303005889 substrate binding site [chemical binding]; other site 697303005890 metal binding site [ion binding]; metal-binding site 697303005891 Amino acid permease; Region: AA_permease; cl00524 697303005892 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 697303005893 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 697303005894 active site 697303005895 dimer interface [polypeptide binding]; other site 697303005896 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 697303005897 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 697303005898 dimer interface [polypeptide binding]; other site 697303005899 glycine-pyridoxal phosphate binding site [chemical binding]; other site 697303005900 active site 697303005901 folate binding site [chemical binding]; other site 697303005902 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 697303005903 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 697303005904 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 697303005905 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 697303005906 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 697303005907 substrate binding site [chemical binding]; other site 697303005908 glutamase interaction surface [polypeptide binding]; other site 697303005909 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 697303005910 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 697303005911 catalytic residues [active] 697303005912 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 697303005913 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 697303005914 putative active site [active] 697303005915 oxyanion strand; other site 697303005916 catalytic triad [active] 697303005917 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 697303005918 putative active site pocket [active] 697303005919 4-fold oligomerization interface [polypeptide binding]; other site 697303005920 metal binding residues [ion binding]; metal-binding site 697303005921 3-fold/trimer interface [polypeptide binding]; other site 697303005922 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 697303005923 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 697303005924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303005925 homodimer interface [polypeptide binding]; other site 697303005926 catalytic residue [active] 697303005927 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 697303005928 histidinol dehydrogenase; Region: hisD; TIGR00069 697303005929 NAD binding site [chemical binding]; other site 697303005930 dimerization interface [polypeptide binding]; other site 697303005931 product binding site; other site 697303005932 substrate binding site [chemical binding]; other site 697303005933 zinc binding site [ion binding]; other site 697303005934 catalytic residues [active] 697303005935 ATP phosphoribosyltransferase; Region: HisG; cl15266 697303005936 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 697303005937 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 697303005938 dimer interface [polypeptide binding]; other site 697303005939 motif 1; other site 697303005940 active site 697303005941 motif 2; other site 697303005942 motif 3; other site 697303005943 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 697303005944 putative active site [active] 697303005945 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 697303005946 active site 697303005947 NTP binding site [chemical binding]; other site 697303005948 metal binding triad [ion binding]; metal-binding site 697303005949 antibiotic binding site [chemical binding]; other site 697303005950 ABC-type uncharacterized transport system involved in gliding motility, auxiliary component [Cell motility and secretion]; Region: GldG; cl15400 697303005951 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 697303005952 ABC-2 type transporter; Region: ABC2_membrane; cl11417 697303005953 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 697303005954 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303005955 Walker A/P-loop; other site 697303005956 ATP binding site [chemical binding]; other site 697303005957 Q-loop/lid; other site 697303005958 ABC transporter signature motif; other site 697303005959 Walker B; other site 697303005960 D-loop; other site 697303005961 H-loop/switch region; other site 697303005962 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 697303005963 Uncharacterized protein conserved in bacteria (DUF2329); Region: DUF2329; pfam10091 697303005964 Putative carbohydrate binding domain; Region: CBM_X; cl05621 697303005965 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 697303005966 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 697303005967 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 697303005968 Putative carbohydrate binding domain; Region: CBM_X; cl05621 697303005969 Glycosyltransferase family 36; Region: Glyco_transf_36; pfam06165 697303005970 Glycosyltransferase 36 associated family; Region: GT36_AF; pfam06205 697303005971 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 697303005972 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 697303005973 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 697303005974 DNA binding residues [nucleotide binding] 697303005975 Serine Recombinase (SR) family, IS607-like transposase subfamily, catalytic domain; members contain a DNA binding domain with homology to MerR/SoxR located N-terminal to the catalytic domain. Serine recombinases catalyze site-specific recombination of...; Region: SR_IS607_transposase_like; cd03769 697303005976 catalytic residues [active] 697303005977 catalytic nucleophile [active] 697303005978 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 697303005979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303005980 S-adenosylmethionine binding site [chemical binding]; other site 697303005981 Uncharacterized conserved protein [Function unknown]; Region: COG3270 697303005982 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 697303005983 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005984 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 697303005985 homoserine O-acetyltransferase; Provisional; Region: metX; cl15472 697303005986 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 697303005987 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 697303005988 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 697303005989 homodimer interface [polypeptide binding]; other site 697303005990 substrate-cofactor binding pocket; other site 697303005991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303005992 catalytic residue [active] 697303005993 homoserine dehydrogenase; Provisional; Region: PRK06349 697303005994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303005995 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 697303005996 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303005997 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303005998 dimerization interface [polypeptide binding]; other site 697303005999 putative DNA binding site [nucleotide binding]; other site 697303006000 putative Zn2+ binding site [ion binding]; other site 697303006001 Integrase core domain; Region: rve; cl01316 697303006002 Transposase [DNA replication, recombination, and repair]; Region: COG5421 697303006003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006004 dimerization interface [polypeptide binding]; other site 697303006005 putative DNA binding site [nucleotide binding]; other site 697303006006 putative Zn2+ binding site [ion binding]; other site 697303006007 ThiC family; Region: ThiC; cl08031 697303006008 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 697303006009 Rubredoxin; Region: Rubredoxin; pfam00301 697303006010 iron binding site [ion binding]; other site 697303006011 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 697303006012 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 697303006013 Ligand Binding Site [chemical binding]; other site 697303006014 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 697303006015 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 697303006016 Na+/H+ antiporter family; Region: Na_H_antiporter; cl15356 697303006017 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 697303006018 active site 697303006019 ADP/pyrophosphate binding site [chemical binding]; other site 697303006020 fructose-1,6-bisphosphate binding site; other site 697303006021 dimerization interface [polypeptide binding]; other site 697303006022 Uncharacterized protein containing a ferredoxin domain [Function unknown]; Region: COG4739 697303006023 Uncharacterized protein containing a ferredoxin domain (DUF2148); Region: DUF2148; pfam09918 697303006024 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 697303006025 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 697303006026 PYR/PP interface [polypeptide binding]; other site 697303006027 dimer interface [polypeptide binding]; other site 697303006028 TPP binding site [chemical binding]; other site 697303006029 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303006030 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 697303006031 TPP-binding site [chemical binding]; other site 697303006032 dimer interface [polypeptide binding]; other site 697303006033 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697303006034 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 697303006035 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 697303006036 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 697303006037 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; cl09156 697303006038 PemK-like protein; Region: PemK; cl00995 697303006039 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 697303006040 Ribbon-helix-helix protein, copG family; Region: RHH_1; cl15375 697303006041 alanine racemase; Reviewed; Region: alr; PRK00053 697303006042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 697303006043 active site 697303006044 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 697303006045 dimer interface [polypeptide binding]; other site 697303006046 substrate binding site [chemical binding]; other site 697303006047 catalytic residues [active] 697303006048 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 697303006049 putative carbohydrate kinase; Provisional; Region: PRK10565 697303006050 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 697303006051 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 697303006052 putative substrate binding site [chemical binding]; other site 697303006053 putative ATP binding site [chemical binding]; other site 697303006054 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 697303006055 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006056 transcriptional repressor DicA; Reviewed; Region: PRK09706 697303006057 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697303006058 non-specific DNA binding site [nucleotide binding]; other site 697303006059 salt bridge; other site 697303006060 sequence-specific DNA binding site [nucleotide binding]; other site 697303006061 hybrid cluster protein; Provisional; Region: PRK05290 697303006062 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 697303006063 ACS interaction site; other site 697303006064 CODH interaction site; other site 697303006065 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 697303006066 hybrid metal cluster; other site 697303006067 Protein of unknown function (DUF503); Region: DUF503; cl00669 697303006068 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 697303006069 putative active site [active] 697303006070 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 697303006071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303006072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303006073 DNA binding residues [nucleotide binding] 697303006074 Uncharacterised protein family UPF0547; Region: UPF0547; pfam10571 697303006075 Double zinc ribbon; Region: DZR; pfam12773 697303006076 cardiolipin synthetase; Reviewed; Region: PRK12452 697303006077 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697303006078 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303006079 Walker A/P-loop; other site 697303006080 ATP binding site [chemical binding]; other site 697303006081 Q-loop/lid; other site 697303006082 ABC transporter signature motif; other site 697303006083 Walker B; other site 697303006084 D-loop; other site 697303006085 H-loop/switch region; other site 697303006086 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 697303006087 peroxiredoxin; Provisional; Region: PRK13189 697303006088 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 697303006089 dimer interface [polypeptide binding]; other site 697303006090 decamer (pentamer of dimers) interface [polypeptide binding]; other site 697303006091 catalytic triad [active] 697303006092 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 697303006093 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697303006094 putative substrate binding site [chemical binding]; other site 697303006095 putative ATP binding site [chemical binding]; other site 697303006096 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 697303006097 hypothetical protein; Provisional; Region: PRK08185 697303006098 intersubunit interface [polypeptide binding]; other site 697303006099 active site 697303006100 zinc binding site [ion binding]; other site 697303006101 Na+ binding site [ion binding]; other site 697303006102 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 697303006103 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 697303006104 substrate binding site [chemical binding]; other site 697303006105 ATP binding site [chemical binding]; other site 697303006106 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 697303006107 TM-ABC transporter signature motif; other site 697303006108 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 697303006109 This family represents the domain I of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses...; Region: ABC_Carb_Monos_I; cd03216 697303006110 Walker A/P-loop; other site 697303006111 ATP binding site [chemical binding]; other site 697303006112 Q-loop/lid; other site 697303006113 ABC transporter signature motif; other site 697303006114 Walker B; other site 697303006115 D-loop; other site 697303006116 H-loop/switch region; other site 697303006117 This family represents domain II of the carbohydrate uptake proteins that transport only monosaccharides (Monos). The Carb_Monos family is involved in the uptake of monosaccharides, such as pentoses (such as xylose, arabinose, and ribose) and hexoses; Region: ABC_Carb_Monos_II; cd03215 697303006118 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 697303006119 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 697303006120 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303006121 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303006122 DNA binding site [nucleotide binding] 697303006123 domain linker motif; other site 697303006124 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 697303006125 ligand binding site [chemical binding]; other site 697303006126 dimerization interface [polypeptide binding]; other site 697303006127 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303006128 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 697303006129 Phd_YefM; Region: PhdYeFM; cl09153 697303006130 Integrase core domain; Region: rve; cl01316 697303006131 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 697303006132 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 697303006133 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 697303006134 catalytic loop [active] 697303006135 iron binding site [ion binding]; other site 697303006136 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 697303006137 methyltransferase cognate corrinoid proteins, Methanosarcina family; Region: pyl_corrinoid; TIGR02370 697303006138 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 697303006139 B12 binding site [chemical binding]; other site 697303006140 cobalt ligand [ion binding]; other site 697303006141 Predicted histidine kinase sensor domain; Region: Hist_Kin_Sens; pfam10114 697303006142 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 697303006143 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697303006144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 697303006145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 697303006146 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 697303006147 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 697303006148 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 697303006149 catalytic loop [active] 697303006150 iron binding site [ion binding]; other site 697303006151 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 697303006152 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303006153 active pocket/dimerization site; other site 697303006154 active site 697303006155 phosphorylation site [posttranslational modification] 697303006156 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 697303006157 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 697303006158 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 697303006159 active site 697303006160 phosphorylation site [posttranslational modification] 697303006161 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006162 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006163 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697303006164 Walker A motif; other site 697303006165 ATP binding site [chemical binding]; other site 697303006166 Walker B motif; other site 697303006167 arginine finger; other site 697303006168 Transcriptional antiterminator [Transcription]; Region: COG3933 697303006169 PRD domain; Region: PRD; cl15445 697303006170 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 697303006171 active pocket/dimerization site; other site 697303006172 active site 697303006173 phosphorylation site [posttranslational modification] 697303006174 PRD domain; Region: PRD; cl15445 697303006175 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303006176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006177 dimerization interface [polypeptide binding]; other site 697303006178 putative DNA binding site [nucleotide binding]; other site 697303006179 putative Zn2+ binding site [ion binding]; other site 697303006180 Integrase core domain; Region: rve; cl01316 697303006181 Protein of unknown function DUF89; Region: DUF89; cl15397 697303006182 Phosphomannose isomerase type I; Region: PMI_typeI; cl15429 697303006183 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 697303006184 Cupin domain; Region: Cupin_2; cl09118 697303006185 Cupin domain; Region: Cupin_2; cl09118 697303006186 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 697303006187 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 697303006188 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021 697303006189 active site 697303006190 phosphorylation site [posttranslational modification] 697303006191 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 697303006192 active pocket/dimerization site; other site 697303006193 active site 697303006194 phosphorylation site [posttranslational modification] 697303006195 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 697303006196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303006197 DNA-binding site [nucleotide binding]; DNA binding site 697303006198 UTRA domain; Region: UTRA; cl01230 697303006199 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303006200 Protein of unknown function DUF91; Region: DUF91; cl00709 697303006201 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 697303006202 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 697303006203 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303006204 putative peptidoglycan binding site; other site 697303006205 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 697303006206 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 697303006207 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 697303006208 putative DNA binding site [nucleotide binding]; other site 697303006209 putative homodimer interface [polypeptide binding]; other site 697303006210 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 697303006211 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 697303006212 active site 697303006213 DNA binding site [nucleotide binding] 697303006214 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 697303006215 DNA binding site [nucleotide binding] 697303006216 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 697303006217 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697303006218 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303006219 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 697303006220 Integrase core domain; Region: rve; cl01316 697303006221 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; cl07370 697303006222 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 697303006223 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697303006224 non-specific DNA binding site [nucleotide binding]; other site 697303006225 salt bridge; other site 697303006226 sequence-specific DNA binding site [nucleotide binding]; other site 697303006227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697303006228 non-specific DNA binding site [nucleotide binding]; other site 697303006229 salt bridge; other site 697303006230 sequence-specific DNA binding site [nucleotide binding]; other site 697303006231 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 697303006232 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 697303006233 DNA binding site [nucleotide binding] 697303006234 Int/Topo IB signature motif; other site 697303006235 active site 697303006236 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 697303006237 DNA primase (bacterial type) [DNA replication, recombination, and repair]; Region: DnaG; COG0358 697303006238 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 697303006239 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 697303006240 active site 697303006241 metal binding site [ion binding]; metal-binding site 697303006242 interdomain interaction site; other site 697303006243 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006244 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697303006245 Walker A motif; other site 697303006246 ATP binding site [chemical binding]; other site 697303006247 Walker B motif; other site 697303006248 arginine finger; other site 697303006249 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 697303006250 Integrase core domain; Region: rve; cl01316 697303006251 Protein of unknown function DUF262; Region: DUF262; cl14890 697303006252 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 697303006253 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 697303006254 putative active site [active] 697303006255 catalytic site [active] 697303006256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697303006257 ATP binding site [chemical binding]; other site 697303006258 putative Mg++ binding site [ion binding]; other site 697303006259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697303006260 nucleotide binding region [chemical binding]; other site 697303006261 ATP-binding site [chemical binding]; other site 697303006262 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 697303006263 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 697303006264 Protein of unknown function (DUF3780); Region: DUF3780; pfam12635 697303006265 Protein of unknown function (DUF499); Region: DUF499; cl15396 697303006266 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303006267 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 697303006268 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 697303006269 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 697303006270 glutaminase active site [active] 697303006271 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 697303006272 dimer interface [polypeptide binding]; other site 697303006273 active site 697303006274 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 697303006275 dimer interface [polypeptide binding]; other site 697303006276 active site 697303006277 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 697303006278 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 697303006279 active site 697303006280 substrate binding site [chemical binding]; other site 697303006281 metal binding site [ion binding]; metal-binding site 697303006282 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 697303006283 putative acyl-acceptor binding pocket; other site 697303006284 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 697303006285 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 697303006286 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 697303006287 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 697303006288 dimer interface [polypeptide binding]; other site 697303006289 PYR/PP interface [polypeptide binding]; other site 697303006290 TPP binding site [chemical binding]; other site 697303006291 substrate binding site [chemical binding]; other site 697303006292 Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008 697303006293 TPP-binding site; other site 697303006294 4Fe-4S binding domain; Region: Fer4; cl02805 697303006295 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 697303006296 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 697303006297 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 697303006298 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 697303006299 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 697303006300 TPP-binding site [chemical binding]; other site 697303006301 2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119 697303006302 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 697303006303 dimer interface [polypeptide binding]; other site 697303006304 PYR/PP interface [polypeptide binding]; other site 697303006305 TPP binding site [chemical binding]; other site 697303006306 substrate binding site [chemical binding]; other site 697303006307 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303006308 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 697303006309 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 697303006310 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303006311 Acetokinase family; Region: Acetate_kinase; cl01029 697303006312 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 697303006313 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 697303006314 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 697303006315 NAD binding site [chemical binding]; other site 697303006316 Phe binding site; other site 697303006317 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 697303006318 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 697303006319 Acetokinase family; Region: Acetate_kinase; cl01029 697303006320 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 697303006321 YbbR-like protein; Region: YbbR; pfam07949 697303006322 YbbR-like protein; Region: YbbR; pfam07949 697303006323 Uncharacterized conserved protein [Function unknown]; Region: COG1624 697303006324 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 697303006325 Transposase domain (DUF772); Region: DUF772; cl12084 697303006326 BON domain; Region: BON; cl02771 697303006327 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 697303006328 Predicted periplasmic or secreted lipoprotein [General function prediction only]; Region: OsmY; COG2823 697303006329 BON domain; Region: BON; cl02771 697303006330 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 697303006331 Ligand Binding Site [chemical binding]; other site 697303006332 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303006333 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303006334 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 697303006335 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 697303006336 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 697303006337 MoxR-like ATPases [General function prediction only]; Region: COG0714 697303006338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006339 Walker A motif; other site 697303006340 ATP binding site [chemical binding]; other site 697303006341 Walker B motif; other site 697303006342 arginine finger; other site 697303006343 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 697303006344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 697303006345 active site 697303006346 motif I; other site 697303006347 motif II; other site 697303006348 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 697303006349 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697303006350 active site 697303006351 metal binding site [ion binding]; metal-binding site 697303006352 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303006353 putative peptidoglycan binding site; other site 697303006354 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 697303006355 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303006356 putative peptidoglycan binding site; other site 697303006357 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303006358 putative peptidoglycan binding site; other site 697303006359 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 697303006360 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303006361 putative peptidoglycan binding site; other site 697303006362 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 697303006363 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303006364 Coat F domain; Region: Coat_F; cl02368 697303006365 Thymidylate synthase complementing protein; Region: Thy1; cl03630 697303006366 Thymidylate synthase complementing protein; Region: Thy1; cl03630 697303006367 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 697303006368 active site 697303006369 DNA binding site [nucleotide binding] 697303006370 putative phosphate binding site [ion binding]; other site 697303006371 putative catalytic site [active] 697303006372 metal binding site A [ion binding]; metal-binding site 697303006373 AP binding site [nucleotide binding]; other site 697303006374 metal binding site B [ion binding]; metal-binding site 697303006375 Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172 697303006376 non-heme iron binding site [ion binding]; other site 697303006377 tetramer interface [polypeptide binding]; other site 697303006378 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 697303006379 putative binding surface; other site 697303006380 active site 697303006381 P2 response regulator binding domain; Region: P2; pfam07194 697303006382 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303006383 ATP binding site [chemical binding]; other site 697303006384 Mg2+ binding site [ion binding]; other site 697303006385 G-X-G motif; other site 697303006386 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 697303006387 Response regulator receiver domain; Region: Response_reg; pfam00072 697303006388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303006389 active site 697303006390 phosphorylation site [posttranslational modification] 697303006391 intermolecular recognition site; other site 697303006392 dimerization interface [polypeptide binding]; other site 697303006393 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 697303006394 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 697303006395 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303006396 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 697303006397 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 697303006398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303006399 active site 697303006400 phosphorylation site [posttranslational modification] 697303006401 intermolecular recognition site; other site 697303006402 dimerization interface [polypeptide binding]; other site 697303006403 CheB methylesterase; Region: CheB_methylest; pfam01339 697303006404 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 697303006405 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 697303006406 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 697303006407 putative CheA interaction surface; other site 697303006408 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 697303006409 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303006410 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303006411 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303006412 Zn2+ binding site [ion binding]; other site 697303006413 Mg2+ binding site [ion binding]; other site 697303006414 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 697303006415 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 697303006416 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 697303006417 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697303006418 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303006419 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 697303006420 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 697303006421 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 697303006422 23S rRNA interface [nucleotide binding]; other site 697303006423 L3 interface [polypeptide binding]; other site 697303006424 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 697303006425 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1); Region: PseudoU_synth_EcTruA; cd02570 697303006426 dimerization interface 3.5A [polypeptide binding]; other site 697303006427 active site 697303006428 Cobalt transport protein; Region: CbiQ; cl00463 697303006429 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637 697303006430 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 697303006431 Walker A/P-loop; other site 697303006432 ATP binding site [chemical binding]; other site 697303006433 Q-loop/lid; other site 697303006434 ABC transporter signature motif; other site 697303006435 Walker B; other site 697303006436 D-loop; other site 697303006437 H-loop/switch region; other site 697303006438 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 697303006439 cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633 697303006440 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This ABC...; Region: ABC_cobalt_CbiO_domain1; cd03225 697303006441 Walker A/P-loop; other site 697303006442 ATP binding site [chemical binding]; other site 697303006443 Q-loop/lid; other site 697303006444 ABC transporter signature motif; other site 697303006445 Walker B; other site 697303006446 D-loop; other site 697303006447 H-loop/switch region; other site 697303006448 Cobalt ATP-binding cassette C terminal; Region: CoABC_C; pfam12370 697303006449 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 697303006450 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 697303006451 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 697303006452 alphaNTD homodimer interface [polypeptide binding]; other site 697303006453 alphaNTD - beta interaction site [polypeptide binding]; other site 697303006454 alphaNTD - beta' interaction site [polypeptide binding]; other site 697303006455 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 697303006456 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 697303006457 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 697303006458 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303006459 RNA binding surface [nucleotide binding]; other site 697303006460 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 697303006461 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 697303006462 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 697303006463 Ribosomal protein L36; Region: Ribosomal_L36; cl00380 697303006464 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 697303006465 rRNA binding site [nucleotide binding]; other site 697303006466 predicted 30S ribosome binding site; other site 697303006467 Ribosomal protein L14E/L6E/L27E [Translation, ribosomal structure and biogenesis]; Region: RPL14A; COG2163 697303006468 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 697303006469 active site 697303006470 adenylate kinase; Reviewed; Region: adk; PRK00279 697303006471 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 697303006472 AMP-binding site [chemical binding]; other site 697303006473 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 697303006474 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 697303006475 SecY translocase; Region: SecY; pfam00344 697303006476 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 697303006477 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 697303006478 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 697303006479 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 697303006480 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 697303006481 5S rRNA interface [nucleotide binding]; other site 697303006482 L27 interface [polypeptide binding]; other site 697303006483 23S rRNA interface [nucleotide binding]; other site 697303006484 L5 interface [polypeptide binding]; other site 697303006485 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 697303006486 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 697303006487 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 697303006488 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 697303006489 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 697303006490 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 697303006491 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 697303006492 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 697303006493 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 697303006494 KOW motif; Region: KOW; cl00354 697303006495 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 697303006496 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 697303006497 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 697303006498 23S rRNA interface [nucleotide binding]; other site 697303006499 putative translocon interaction site; other site 697303006500 signal recognition particle (SRP54) interaction site; other site 697303006501 L23 interface [polypeptide binding]; other site 697303006502 trigger factor interaction site; other site 697303006503 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 697303006504 23S rRNA interface [nucleotide binding]; other site 697303006505 5S rRNA interface [nucleotide binding]; other site 697303006506 putative antibiotic binding site [chemical binding]; other site 697303006507 L25 interface [polypeptide binding]; other site 697303006508 L27 interface [polypeptide binding]; other site 697303006509 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 697303006510 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 697303006511 G-X-X-G motif; other site 697303006512 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 697303006513 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 697303006514 putative translocon binding site; other site 697303006515 protein-rRNA interface [nucleotide binding]; other site 697303006516 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 697303006517 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 697303006518 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 697303006519 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 697303006520 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 697303006521 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 697303006522 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 697303006523 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 697303006524 elongation factor Tu; Reviewed; Region: PRK00049 697303006525 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 697303006526 G1 box; other site 697303006527 GEF interaction site [polypeptide binding]; other site 697303006528 GTP/Mg2+ binding site [chemical binding]; other site 697303006529 Switch I region; other site 697303006530 G2 box; other site 697303006531 G3 box; other site 697303006532 Switch II region; other site 697303006533 G4 box; other site 697303006534 G5 box; other site 697303006535 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 697303006536 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 697303006537 Antibiotic Binding Site [chemical binding]; other site 697303006538 elongation factor G; Reviewed; Region: PRK00007 697303006539 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G; cd01886 697303006540 G1 box; other site 697303006541 putative GEF interaction site [polypeptide binding]; other site 697303006542 GTP/Mg2+ binding site [chemical binding]; other site 697303006543 Switch I region; other site 697303006544 G2 box; other site 697303006545 G3 box; other site 697303006546 Switch II region; other site 697303006547 G4 box; other site 697303006548 G5 box; other site 697303006549 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 697303006550 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 697303006551 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 697303006552 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 697303006553 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 697303006554 S17 interaction site [polypeptide binding]; other site 697303006555 S8 interaction site; other site 697303006556 16S rRNA interaction site [nucleotide binding]; other site 697303006557 streptomycin interaction site [chemical binding]; other site 697303006558 23S rRNA interaction site [nucleotide binding]; other site 697303006559 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 697303006560 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 697303006561 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 697303006562 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 697303006563 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 697303006564 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 697303006565 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 697303006566 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 697303006567 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 697303006568 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 697303006569 G-loop; other site 697303006570 DNA binding site [nucleotide binding] 697303006571 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 697303006572 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 697303006573 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 697303006574 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 697303006575 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 697303006576 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 697303006577 RPB1 interaction site [polypeptide binding]; other site 697303006578 RPB10 interaction site [polypeptide binding]; other site 697303006579 RPB11 interaction site [polypeptide binding]; other site 697303006580 RPB3 interaction site [polypeptide binding]; other site 697303006581 RPB12 interaction site [polypeptide binding]; other site 697303006582 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 697303006583 core dimer interface [polypeptide binding]; other site 697303006584 peripheral dimer interface [polypeptide binding]; other site 697303006585 L10 interface [polypeptide binding]; other site 697303006586 L11 interface [polypeptide binding]; other site 697303006587 putative EF-Tu interaction site [polypeptide binding]; other site 697303006588 putative EF-G interaction site [polypeptide binding]; other site 697303006589 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 697303006590 23S rRNA interface [nucleotide binding]; other site 697303006591 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 697303006592 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 697303006593 mRNA/rRNA interface [nucleotide binding]; other site 697303006594 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 697303006595 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 697303006596 23S rRNA interface [nucleotide binding]; other site 697303006597 L7/L12 interface [polypeptide binding]; other site 697303006598 putative thiostrepton binding site; other site 697303006599 L25 interface [polypeptide binding]; other site 697303006600 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 697303006601 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 697303006602 putative homodimer interface [polypeptide binding]; other site 697303006603 KOW motif; Region: KOW; cl00354 697303006604 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 697303006605 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 697303006606 elongation factor Tu; Reviewed; Region: PRK00049 697303006607 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 697303006608 G1 box; other site 697303006609 GEF interaction site [polypeptide binding]; other site 697303006610 GTP/Mg2+ binding site [chemical binding]; other site 697303006611 Switch I region; other site 697303006612 G2 box; other site 697303006613 G3 box; other site 697303006614 Switch II region; other site 697303006615 G4 box; other site 697303006616 G5 box; other site 697303006617 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 697303006618 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 697303006619 Antibiotic Binding Site [chemical binding]; other site 697303006620 RNA polymerase sigma-H factor; Region: spore_sigH; TIGR02859 697303006621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303006622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl15358 697303006623 YacP-like NYN domain; Region: NYN_YacP; cl01491 697303006624 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 697303006625 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 697303006626 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 697303006627 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 697303006628 active site 697303006629 metal binding site [ion binding]; metal-binding site 697303006630 dimerization interface [polypeptide binding]; other site 697303006631 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 697303006632 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 697303006633 active site 697303006634 HIGH motif; other site 697303006635 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 697303006636 KMSKS motif; other site 697303006637 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 697303006638 tRNA binding surface [nucleotide binding]; other site 697303006639 anticodon binding site; other site 697303006640 serine O-acetyltransferase; Region: cysE; TIGR01172 697303006641 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 697303006642 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 697303006643 trimer interface [polypeptide binding]; other site 697303006644 active site 697303006645 substrate binding site [chemical binding]; other site 697303006646 CoA binding site [chemical binding]; other site 697303006647 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 697303006648 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697303006649 HIGH motif; other site 697303006650 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 697303006651 active site 697303006652 KMSKS motif; other site 697303006653 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 697303006654 prolyl-tRNA synthetase; Provisional; Region: PRK09194 697303006655 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of...; Region: ProRS_core_prok; cd00779 697303006656 dimer interface [polypeptide binding]; other site 697303006657 motif 1; other site 697303006658 active site 697303006659 motif 2; other site 697303006660 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 697303006661 putative deacylase active site [active] 697303006662 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it attaches...; Region: class_II_aaRS-like_core; cl00268 697303006663 active site 697303006664 motif 3; other site 697303006665 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 697303006666 anticodon binding site; other site 697303006667 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 697303006668 homotrimer interaction site [polypeptide binding]; other site 697303006669 zinc binding site [ion binding]; other site 697303006670 CDP-binding sites; other site 697303006671 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303006672 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 697303006673 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 697303006674 substrate binding site; other site 697303006675 dimer interface; other site 697303006676 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 697303006677 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 697303006678 putative active site [active] 697303006679 DNA repair protein RadA; Provisional; Region: PRK11823 697303006680 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 697303006681 Walker A motif/ATP binding site; other site 697303006682 ATP binding site [chemical binding]; other site 697303006683 Walker B motif; other site 697303006684 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 697303006685 Natural resistance-associated macrophage protein; Region: Nramp; cl00836 697303006686 manganese transport transcriptional regulator; Provisional; Region: PRK03902 697303006687 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006688 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 697303006689 Clp protease ATP binding subunit; Region: clpC; CHL00095 697303006690 Clp amino terminal domain; Region: Clp_N; pfam02861 697303006691 Clp amino terminal domain; Region: Clp_N; pfam02861 697303006692 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006693 Walker A motif; other site 697303006694 ATP binding site [chemical binding]; other site 697303006695 Walker B motif; other site 697303006696 arginine finger; other site 697303006697 UvrB/uvrC motif; Region: UVR; pfam02151 697303006698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006699 Walker A motif; other site 697303006700 ATP binding site [chemical binding]; other site 697303006701 Walker B motif; other site 697303006702 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 697303006703 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 697303006704 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 697303006705 ADP binding site [chemical binding]; other site 697303006706 phosphagen binding site; other site 697303006707 substrate specificity loop; other site 697303006708 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 697303006709 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 697303006710 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 697303006711 Malic enzyme, N-terminal domain; Region: malic; pfam00390 697303006712 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 697303006713 putative NAD(P) binding site [chemical binding]; other site 697303006714 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved so...; Region: EF-G_bact; cd04170 697303006715 elongation factor G; Reviewed; Region: PRK12740 697303006716 G1 box; other site 697303006717 putative GEF interaction site [polypeptide binding]; other site 697303006718 GTP/Mg2+ binding site [chemical binding]; other site 697303006719 Switch I region; other site 697303006720 G2 box; other site 697303006721 G3 box; other site 697303006722 Switch II region; other site 697303006723 G4 box; other site 697303006724 G5 box; other site 697303006725 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 697303006726 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 697303006727 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 697303006728 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 697303006729 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 697303006730 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 697303006731 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 697303006732 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 697303006733 P-loop; other site 697303006734 active site 697303006735 phosphorylation site [posttranslational modification] 697303006736 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 697303006737 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697303006738 active site 697303006739 phosphorylation site [posttranslational modification] 697303006740 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 697303006741 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006743 PRD domain; Region: PRD; cl15445 697303006744 PRD domain; Region: PRD; cl15445 697303006745 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 697303006746 P-loop; other site 697303006747 active site 697303006748 phosphorylation site [posttranslational modification] 697303006749 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697303006750 active site 697303006751 phosphorylation site [posttranslational modification] 697303006752 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 697303006753 GAF domain; Region: GAF; cl00853 697303006754 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303006755 metal binding site [ion binding]; metal-binding site 697303006756 active site 697303006757 I-site; other site 697303006758 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 697303006759 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 697303006760 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 697303006761 active site 697303006762 dimer interface [polypeptide binding]; other site 697303006763 effector binding site; other site 697303006764 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 697303006765 TSCPD domain; Region: TSCPD; cl14834 697303006766 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 697303006767 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 697303006768 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697303006769 inhibitor-cofactor binding pocket; inhibition site 697303006770 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303006771 catalytic residue [active] 697303006772 Protein of unknown function (DUF1614); Region: DUF1614; cl15407 697303006773 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 697303006774 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cl12031 697303006775 Sugar fermentation stimulation protein; Region: SfsA; cl00647 697303006776 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 697303006777 active site 697303006778 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 697303006779 catalytic center binding site [active] 697303006780 ATP binding site [chemical binding]; other site 697303006781 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 697303006782 dihydropteroate synthase; Region: DHPS; TIGR01496 697303006783 substrate binding pocket [chemical binding]; other site 697303006784 dimer interface [polypeptide binding]; other site 697303006785 inhibitor binding site; inhibition site 697303006786 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 697303006787 homodecamer interface [polypeptide binding]; other site 697303006788 GTP cyclohydrolase I; Provisional; Region: PLN03044 697303006789 active site 697303006790 putative catalytic site residues [active] 697303006791 zinc binding site [ion binding]; other site 697303006792 GTP-CH-I/GFRP interaction surface; other site 697303006793 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 697303006794 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 697303006795 dimer interface [polypeptide binding]; other site 697303006796 putative anticodon binding site; other site 697303006797 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 697303006798 motif 1; other site 697303006799 active site 697303006800 motif 2; other site 697303006801 motif 3; other site 697303006802 domain; Region: GreA_GreB_N; pfam03449 697303006803 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 697303006804 Predicted dehydrogenase [General function prediction only]; Region: COG5322 697303006805 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 697303006806 NADP binding site [chemical binding]; other site 697303006807 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006808 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 697303006809 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 697303006810 Amino acid permease; Region: AA_permease; cl00524 697303006811 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 697303006812 Predicted membrane protein [Function unknown]; Region: COG4684 697303006813 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 697303006814 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 697303006815 carboxyltransferase (CT) interaction site; other site 697303006816 biotinylation site [posttranslational modification]; other site 697303006817 methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117 697303006818 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 697303006819 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 697303006820 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697303006821 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 697303006822 dimer interface [polypeptide binding]; other site 697303006823 substrate binding site [chemical binding]; other site 697303006824 metal binding site [ion binding]; metal-binding site 697303006825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303006826 ArgK protein; Region: ArgK; pfam03308 697303006827 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 697303006828 Walker A; other site 697303006829 G1 box; other site 697303006830 GTP/Mg2+ binding site [chemical binding]; other site 697303006831 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303006832 G4 box; other site 697303006833 G5 box; other site 697303006834 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 697303006835 B12 binding site [chemical binding]; other site 697303006836 cobalt ligand [ion binding]; other site 697303006837 Methylmalonyl-CoA mutase, N-terminal domain/subunit [Lipid metabolism]; Region: Sbm; COG1884 697303006838 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680 697303006839 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 697303006840 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 697303006841 Potassium binding sites [ion binding]; other site 697303006842 Cesium cation binding sites [ion binding]; other site 697303006843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303006844 PAS fold; Region: PAS; pfam00989 697303006845 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 697303006846 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303006847 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303006848 dimer interface [polypeptide binding]; other site 697303006849 phosphorylation site [posttranslational modification] 697303006850 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303006851 ATP binding site [chemical binding]; other site 697303006852 Mg2+ binding site [ion binding]; other site 697303006853 G-X-G motif; other site 697303006854 FtsH Extracellular; Region: FtsH_ext; pfam06480 697303006855 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 697303006856 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006857 Walker A motif; other site 697303006858 ATP binding site [chemical binding]; other site 697303006859 Walker B motif; other site 697303006860 arginine finger; other site 697303006861 Peptidase family M41; Region: Peptidase_M41; pfam01434 697303006862 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303006863 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 697303006864 Ligand Binding Site [chemical binding]; other site 697303006865 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 697303006866 B3/4 domain; Region: B3_4; cl11458 697303006867 stage II sporulation protein E; Region: spore_II_E; TIGR02865 697303006868 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 697303006869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303006870 S-adenosylmethionine binding site [chemical binding]; other site 697303006871 Uncharacterised protein family (UPF0236); Region: UPF0236; pfam06782 697303006872 EamA-like transporter family; Region: EamA; cl01037 697303006873 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 697303006874 EamA-like transporter family; Region: EamA; cl01037 697303006875 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 697303006876 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303006877 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303006878 DNA binding residues [nucleotide binding] 697303006879 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 697303006880 Predicted integral membrane protein (DUF2275); Region: DUF2275; pfam10039 697303006881 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697303006882 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 697303006883 Walker A/P-loop; other site 697303006884 ATP binding site [chemical binding]; other site 697303006885 Q-loop/lid; other site 697303006886 ABC transporter signature motif; other site 697303006887 Walker B; other site 697303006888 D-loop; other site 697303006889 H-loop/switch region; other site 697303006890 ABC-2 type transporter; Region: ABC2_membrane; cl11417 697303006891 Protein of unknown function (DUF1284); Region: DUF1284; cl01419 697303006892 Domain of unknown function (DUF3787); Region: DUF3787; pfam12655 697303006893 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 697303006894 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 697303006895 dimer interface [polypeptide binding]; other site 697303006896 PYR/PP interface [polypeptide binding]; other site 697303006897 TPP binding site [chemical binding]; other site 697303006898 substrate binding site [chemical binding]; other site 697303006899 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 697303006900 Domain of unknown function; Region: EKR; cl11037 697303006901 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 697303006902 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 697303006903 TPP-binding site [chemical binding]; other site 697303006904 dimer interface [polypeptide binding]; other site 697303006905 Threonine dehydrogenase; Region: TDH; cd05281 697303006906 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 697303006907 structural Zn binding site [ion binding]; other site 697303006908 catalytic Zn binding site [ion binding]; other site 697303006909 tetramer interface [polypeptide binding]; other site 697303006910 NADP binding site [chemical binding]; other site 697303006911 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 697303006912 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 697303006913 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303006914 catalytic residue [active] 697303006915 Permease family; Region: Xan_ur_permease; cl00967 697303006916 Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890 697303006917 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 697303006918 active site 697303006919 metal binding site [ion binding]; metal-binding site 697303006920 Domain of unknown function DUF59; Region: DUF59; cl00941 697303006921 Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284 697303006922 GAF domain; Region: GAF; cl00853 697303006923 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303006924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006925 Walker A motif; other site 697303006926 ATP binding site [chemical binding]; other site 697303006927 Walker B motif; other site 697303006928 arginine finger; other site 697303006929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303006930 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 697303006931 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 697303006932 tetramer interface [polypeptide binding]; other site 697303006933 TPP-binding site [chemical binding]; other site 697303006934 heterodimer interface [polypeptide binding]; other site 697303006935 phosphorylation loop region [posttranslational modification] 697303006936 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 697303006937 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 697303006938 alpha subunit interface [polypeptide binding]; other site 697303006939 TPP binding site [chemical binding]; other site 697303006940 heterodimer interface [polypeptide binding]; other site 697303006941 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 697303006942 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 697303006943 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 697303006944 E3 interaction surface; other site 697303006945 lipoyl attachment site [posttranslational modification]; other site 697303006946 e3 binding domain; Region: E3_binding; pfam02817 697303006947 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; cl02008 697303006948 Domain of unknown function DUF302; Region: DUF302; cl01364 697303006949 Response regulator receiver domain; Region: Response_reg; pfam00072 697303006950 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303006951 active site 697303006952 phosphorylation site [posttranslational modification] 697303006953 intermolecular recognition site; other site 697303006954 dimerization interface [polypeptide binding]; other site 697303006955 PAS domain S-box; Region: sensory_box; TIGR00229 697303006956 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303006957 PAS domain S-box; Region: sensory_box; TIGR00229 697303006958 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303006959 putative active site [active] 697303006960 heme pocket [chemical binding]; other site 697303006961 PAS domain S-box; Region: sensory_box; TIGR00229 697303006962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303006963 putative active site [active] 697303006964 heme pocket [chemical binding]; other site 697303006965 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303006966 metal binding site [ion binding]; metal-binding site 697303006967 active site 697303006968 I-site; other site 697303006969 Protein of unknown function (DUF342); Region: DUF342; pfam03961 697303006970 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303006971 metal binding site [ion binding]; metal-binding site 697303006972 active site 697303006973 I-site; other site 697303006974 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 697303006975 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 697303006976 Protein of unknown function (DUF1648); Region: DUF1648; cl01712 697303006977 Protein of unknown function (DUF3006); Region: DUF3006; pfam11213 697303006978 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 697303006979 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 697303006980 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 697303006981 putative metal binding site [ion binding]; other site 697303006982 Transposase domain (DUF772); Region: DUF772; cl12084 697303006983 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303006984 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 697303006985 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 697303006986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303006987 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 697303006988 Walker A motif; other site 697303006989 ATP binding site [chemical binding]; other site 697303006990 Walker B motif; other site 697303006991 arginine finger; other site 697303006992 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 697303006993 Chitin synthase; Region: Chitin_synth_2; pfam03142 697303006994 DXD motif; other site 697303006995 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 697303006996 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 697303006997 PBS lyase HEAT-like repeat; Region: HEAT_PBS; cl15388 697303006998 Response regulator receiver domain; Region: Response_reg; pfam00072 697303006999 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303007000 active site 697303007001 phosphorylation site [posttranslational modification] 697303007002 intermolecular recognition site; other site 697303007003 dimerization interface [polypeptide binding]; other site 697303007004 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303007005 metal binding site [ion binding]; metal-binding site 697303007006 active site 697303007007 I-site; other site 697303007008 Response regulator receiver domain; Region: Response_reg; pfam00072 697303007009 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303007010 active site 697303007011 phosphorylation site [posttranslational modification] 697303007012 intermolecular recognition site; other site 697303007013 dimerization interface [polypeptide binding]; other site 697303007014 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 697303007015 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 697303007016 metal binding site [ion binding]; metal-binding site 697303007017 active site 697303007018 I-site; other site 697303007019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 697303007020 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 697303007021 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 697303007022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303007023 ATP binding site [chemical binding]; other site 697303007024 Mg2+ binding site [ion binding]; other site 697303007025 G-X-G motif; other site 697303007026 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 697303007027 Sulphate Transporter and Anti-Sigma factor antagonist domain of the 'stressosome' complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 697303007028 Transposase, Mutator family; Region: Transposase_mut; pfam00872 697303007029 MULE transposase domain; Region: MULE; pfam10551 697303007030 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303007031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303007032 Walker A motif; other site 697303007033 ATP binding site [chemical binding]; other site 697303007034 Walker B motif; other site 697303007035 arginine finger; other site 697303007036 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 697303007037 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 697303007038 P-loop; other site 697303007039 Magnesium ion binding site [ion binding]; other site 697303007040 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 697303007041 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 697303007042 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 697303007043 Walker A motif; other site 697303007044 hexamer interface [polypeptide binding]; other site 697303007045 ATP binding site [chemical binding]; other site 697303007046 Walker B motif; other site 697303007047 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 697303007048 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007049 SAF domain; Region: SAF; cl00555 697303007050 Peptidase family M23; Region: Peptidase_M23; pfam01551 697303007051 AAA-like domain; Region: AAA_10; pfam12846 697303007052 Domain of unknown function DUF87; Region: DUF87; pfam01935 697303007053 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 697303007054 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 697303007055 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007056 Walker A motif; other site 697303007057 ATP binding site [chemical binding]; other site 697303007058 Walker B motif; other site 697303007059 plasmid segregation protein ParM; Provisional; Region: PRK13917 697303007060 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 697303007061 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 697303007062 Zn2+ binding site [ion binding]; other site 697303007063 Mg2+ binding site [ion binding]; other site 697303007064 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 697303007065 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 697303007066 putative NADP binding site [chemical binding]; other site 697303007067 putative substrate binding site [chemical binding]; other site 697303007068 active site 697303007069 Tetrahydromethanopterin S-methyltransferase subunit B; Region: MtrB; cl01678 697303007070 manganese transport regulator MntR; Provisional; Region: PRK11050 697303007071 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697303007072 non-specific DNA binding site [nucleotide binding]; other site 697303007073 salt bridge; other site 697303007074 sequence-specific DNA binding site [nucleotide binding]; other site 697303007075 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697303007076 non-specific DNA binding site [nucleotide binding]; other site 697303007077 salt bridge; other site 697303007078 sequence-specific DNA binding site [nucleotide binding]; other site 697303007079 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl15449 697303007080 hypothetical protein; Provisional; Region: PRK05807 697303007081 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_hs4; cd05692 697303007082 RNA binding site [nucleotide binding]; other site 697303007083 Septum formation initiator; Region: DivIC; cl11433 697303007084 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 697303007085 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK14869 697303007086 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc2; cd04597 697303007087 DRTGG domain; Region: DRTGG; cl12147 697303007088 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 697303007089 DHH family; Region: DHH; pfam01368 697303007090 DHHA2 domain; Region: DHHA2; pfam02833 697303007091 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303007092 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 697303007093 YabP family; Region: YabP; cl06766 697303007094 Stage II sporulation protein; Region: SpoIID; pfam08486 697303007095 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 697303007096 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 697303007097 RNA binding surface [nucleotide binding]; other site 697303007098 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 697303007099 IHF dimer interface [polypeptide binding]; other site 697303007100 IHF - DNA interface [nucleotide binding]; other site 697303007101 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 697303007102 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 697303007103 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 697303007104 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697303007105 non-specific DNA binding site [nucleotide binding]; other site 697303007106 salt bridge; other site 697303007107 sequence-specific DNA binding site [nucleotide binding]; other site 697303007108 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 697303007109 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 697303007110 binding surface 697303007111 TPR motif; other site 697303007112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 697303007113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303007114 H+ Antiporter protein; Region: 2A0121; TIGR00900 697303007115 putative substrate translocation pore; other site 697303007116 hydrogenase maturation GTPase HydF; Region: GTP_HydF; TIGR03918 697303007117 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs); Region: Era_like; cd00880 697303007118 G1 box; other site 697303007119 GTP/Mg2+ binding site [chemical binding]; other site 697303007120 Switch I region; other site 697303007121 G2 box; other site 697303007122 Switch II region; other site 697303007123 G3 box; other site 697303007124 G4 box; other site 697303007125 G5 box; other site 697303007126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303007127 dimerization interface [polypeptide binding]; other site 697303007128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303007129 dimer interface [polypeptide binding]; other site 697303007130 phosphorylation site [posttranslational modification] 697303007131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303007132 ATP binding site [chemical binding]; other site 697303007133 Mg2+ binding site [ion binding]; other site 697303007134 G-X-G motif; other site 697303007135 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697303007136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303007137 active site 697303007138 phosphorylation site [posttranslational modification] 697303007139 intermolecular recognition site; other site 697303007140 dimerization interface [polypeptide binding]; other site 697303007141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303007142 DNA binding site [nucleotide binding] 697303007143 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 697303007144 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small; Region: DSRD; cd00974 697303007145 non-heme iron binding site [ion binding]; other site 697303007146 dimer interface [polypeptide binding]; other site 697303007147 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_Dfx_classI; cd03171 697303007148 non-heme iron binding site [ion binding]; other site 697303007149 dimer interface [polypeptide binding]; other site 697303007150 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 697303007151 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 697303007152 Predicted amidohydrolase [General function prediction only]; Region: COG0388 697303007153 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 697303007154 active site 697303007155 catalytic triad [active] 697303007156 dimer interface [polypeptide binding]; other site 697303007157 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 697303007158 active site 697303007159 catalytic triad [active] 697303007160 dimer interface [polypeptide binding]; other site 697303007161 Protein of unknown function (DUF1237); Region: DUF1237; cl15402 697303007162 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 697303007163 Ligand Binding Site [chemical binding]; other site 697303007164 TIGR00269 family protein; Region: TIGR00269 697303007165 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 697303007166 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 697303007167 putative ATP binding site [chemical binding]; other site 697303007168 putative substrate interface [chemical binding]; other site 697303007169 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 697303007170 Major membrane immunogen, membrane-anchored lipoprotein [Function unknown]; Region: COG4939 697303007171 FMN-binding domain; Region: FMN_bind; cl01081 697303007172 UbiA prenyltransferase family; Region: UbiA; cl00337 697303007173 ApbE family; Region: ApbE; cl00643 697303007174 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 697303007175 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 697303007176 substrate binding pocket [chemical binding]; other site 697303007177 chain length determination region; other site 697303007178 substrate-Mg2+ binding site; other site 697303007179 catalytic residues [active] 697303007180 aspartate-rich region 1; other site 697303007181 active site lid residues [active] 697303007182 aspartate-rich region 2; other site 697303007183 Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; cl01973 697303007184 Listerrria innocua Lin0431 is similar to the N-Utilization Substance G (NusG) N terminal (NGN) insert (DII); Region: Lin0431_like; cd09911 697303007185 trimer interface [polypeptide binding]; other site 697303007186 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 697303007187 Ferritin-like domain; Region: Ferritin; pfam00210 697303007188 ferroxidase diiron center [ion binding]; other site 697303007189 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697303007190 catalytic core [active] 697303007191 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 697303007192 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 697303007193 Coenzyme A binding pocket [chemical binding]; other site 697303007194 N-acetylglutamate synthase; Validated; Region: PRK05279 697303007195 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; cl02270 697303007196 PIN domain of the Rv0301 toxin of Mycobacterium tuberculosis and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MtRv0301; cd09882 697303007197 putative active site [active] 697303007198 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 697303007199 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 697303007200 Walker A/P-loop; other site 697303007201 ATP binding site [chemical binding]; other site 697303007202 Q-loop/lid; other site 697303007203 ABC transporter signature motif; other site 697303007204 Walker B; other site 697303007205 D-loop; other site 697303007206 H-loop/switch region; other site 697303007207 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: MutS; COG0249 697303007208 The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family also possess a conserved ATPase activity that...; Region: ABC_MutS_homologs; cd03243 697303007209 Walker A/P-loop; other site 697303007210 ATP binding site [chemical binding]; other site 697303007211 Q-loop/lid; other site 697303007212 ABC transporter signature motif; other site 697303007213 Walker B; other site 697303007214 D-loop; other site 697303007215 H-loop/switch region; other site 697303007216 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 697303007217 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 697303007218 Cl- selectivity filter; other site 697303007219 Cl- binding residues [ion binding]; other site 697303007220 pore gating glutamate residue; other site 697303007221 dimer interface [polypeptide binding]; other site 697303007222 H+/Cl- coupling transport residue; other site 697303007223 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl15357 697303007224 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303007225 Predicted membrane protein [Function unknown]; Region: COG2733 697303007226 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 697303007227 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 697303007228 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 697303007229 DNA binding residues [nucleotide binding] 697303007230 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 697303007231 This family of ATP-binding proteins belongs to a multisubunit transporter involved in drug resistance (BcrA and DrrA), nodulation, lipid transport, and lantibiotic immunity. In bacteria and archaea, these transporters usually include an ATP-binding...; Region: ABC_DR_subfamily_A; cd03230 697303007232 Walker A/P-loop; other site 697303007233 ATP binding site [chemical binding]; other site 697303007234 Q-loop/lid; other site 697303007235 ABC transporter signature motif; other site 697303007236 Walker B; other site 697303007237 D-loop; other site 697303007238 H-loop/switch region; other site 697303007239 Predicted transcriptional regulators [Transcription]; Region: COG1725 697303007240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303007241 DNA-binding site [nucleotide binding]; DNA binding site 697303007242 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 697303007243 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 697303007244 active site 697303007245 Zn binding site [ion binding]; other site 697303007246 argininosuccinate lyase; Provisional; Region: PRK00855 697303007247 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 697303007248 active sites [active] 697303007249 tetramer interface [polypeptide binding]; other site 697303007250 Argininosuccinate synthase [Amino acid transport and metabolism]; Region: ArgG; COG0137 697303007251 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 697303007252 ANP binding site [chemical binding]; other site 697303007253 Substrate Binding Site II [chemical binding]; other site 697303007254 Substrate Binding Site I [chemical binding]; other site 697303007255 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 697303007256 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697303007257 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 697303007258 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 697303007259 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 697303007260 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 697303007261 substrate binding site [chemical binding]; other site 697303007262 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 697303007263 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 697303007264 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 697303007265 catalytic site [active] 697303007266 subunit interface [polypeptide binding]; other site 697303007267 acetylornithine aminotransferase; Provisional; Region: PRK02627 697303007268 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 697303007269 inhibitor-cofactor binding pocket; inhibition site 697303007270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303007271 catalytic residue [active] 697303007272 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 697303007273 feedback inhibition sensing region; other site 697303007274 homohexameric interface [polypeptide binding]; other site 697303007275 nucleotide binding site [chemical binding]; other site 697303007276 N-acetyl-L-glutamate binding site [chemical binding]; other site 697303007277 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 697303007278 heterotetramer interface [polypeptide binding]; other site 697303007279 active site pocket [active] 697303007280 cleavage site 697303007281 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 697303007282 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007283 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 697303007284 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 697303007285 Iron only hydrogenase large subunit, C-terminal domain [General function prediction only]; Region: COG4624 697303007286 4Fe-4S binding domain; Region: Fer4; cl02805 697303007287 4Fe-4S binding domain; Region: Fer4; cl02805 697303007288 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 697303007289 electron transport complex, RnfABCDGE type, B subunit; Region: rnfB; TIGR01944 697303007290 Putative Fe-S cluster; Region: FeS; pfam04060 697303007291 PAS domain S-box; Region: sensory_box; TIGR00229 697303007292 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 697303007293 putative active site [active] 697303007294 heme pocket [chemical binding]; other site 697303007295 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 697303007296 dimer interface [polypeptide binding]; other site 697303007297 [2Fe-2S] cluster binding site [ion binding]; other site 697303007298 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 697303007299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303007300 dimerization interface [polypeptide binding]; other site 697303007301 putative DNA binding site [nucleotide binding]; other site 697303007302 putative Zn2+ binding site [ion binding]; other site 697303007303 Integrase core domain; Region: rve; cl01316 697303007304 NADP(H)-dependent alcohol dehydrogenases; Region: NADP_ADH; cd08285 697303007305 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 697303007306 tetramer interface [polypeptide binding]; other site 697303007307 catalytic Zn binding site [ion binding]; other site 697303007308 NADP binding site [chemical binding]; other site 697303007309 ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222 697303007310 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219 697303007311 FAD binding pocket [chemical binding]; other site 697303007312 FAD binding motif [chemical binding]; other site 697303007313 phosphate binding motif [ion binding]; other site 697303007314 beta-alpha-beta structure motif; other site 697303007315 NAD binding pocket [chemical binding]; other site 697303007316 Iron coordination center [ion binding]; other site 697303007317 putative oxidoreductase; Provisional; Region: PRK12831 697303007318 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303007320 sugar efflux transporter; Region: 2A0120; TIGR00899 697303007321 putative substrate translocation pore; other site 697303007322 Putative cyclase; Region: Cyclase; cl00814 697303007323 hypothetical protein; Provisional; Region: PRK08609 697303007324 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 697303007325 active site 697303007326 primer binding site [nucleotide binding]; other site 697303007327 NTP binding site [chemical binding]; other site 697303007328 metal binding triad [ion binding]; metal-binding site 697303007329 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303007330 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 697303007331 magnesium-transporting ATPase; Provisional; Region: PRK15122 697303007332 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 697303007333 Haloacid Dehalogenase-like Hydrolases; Region: HAD_like; cl11391 697303007334 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 697303007335 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 697303007336 active site 697303007337 Protein of unknown function (DUF1393); Region: DUF1393; cl01942 697303007338 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 697303007339 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 697303007340 Glucan exporter ATP-binding protein. In A. tumefaciens cyclic beta-1, 2-glucan must be transported into the periplasmic space to exert its action as a virluence factor. This subfamily belongs to the MRP-like family and is involved in drug, peptide, and...; Region: ABCC_Glucan_exporter_like; cd03254 697303007341 Walker A/P-loop; other site 697303007342 ATP binding site [chemical binding]; other site 697303007343 Q-loop/lid; other site 697303007344 ABC transporter signature motif; other site 697303007345 Walker B; other site 697303007346 D-loop; other site 697303007347 H-loop/switch region; other site 697303007348 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697303007349 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 697303007350 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007351 Walker A/P-loop; other site 697303007352 ATP binding site [chemical binding]; other site 697303007353 Q-loop/lid; other site 697303007354 ABC transporter signature motif; other site 697303007355 Walker B; other site 697303007356 D-loop; other site 697303007357 H-loop/switch region; other site 697303007358 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 697303007359 putative DNA binding site [nucleotide binding]; other site 697303007360 putative Zn2+ binding site [ion binding]; other site 697303007361 hypothetical protein; Provisional; Region: PRK08609 697303007362 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 697303007363 active site 697303007364 primer binding site [nucleotide binding]; other site 697303007365 NTP binding site [chemical binding]; other site 697303007366 metal binding triad [ion binding]; metal-binding site 697303007367 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 697303007368 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 697303007369 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 697303007370 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 697303007371 DNA binding site [nucleotide binding] 697303007372 active site 697303007373 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 697303007374 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 697303007375 putative catalytic cysteine [active] 697303007376 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 697303007377 putative active site [active] 697303007378 metal binding site [ion binding]; metal-binding site 697303007379 SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913 697303007380 SH3 domain of SH3b2 type; Region: SH3_7; pfam12914 697303007381 NlpC/P60 family; Region: NLPC_P60; cl11438 697303007382 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 697303007383 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 697303007384 active site 697303007385 catalytic tetrad [active] 697303007386 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 697303007387 Acetyl-CoA Synthetase and similar proteins; Region: Acetyl-CoA_Synthetase; cl15355 697303007388 Transposase [DNA replication, recombination, and repair]; Region: COG5421 697303007389 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 697303007390 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 697303007391 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 697303007392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303007393 dimer interface [polypeptide binding]; other site 697303007394 conserved gate region; other site 697303007395 putative PBP binding loops; other site 697303007396 ABC-ATPase subunit interface; other site 697303007397 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 697303007398 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 697303007399 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 697303007400 dimer interface [polypeptide binding]; other site 697303007401 conserved gate region; other site 697303007402 putative PBP binding loops; other site 697303007403 ABC-ATPase subunit interface; other site 697303007404 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 697303007405 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 697303007406 Walker A/P-loop; other site 697303007407 ATP binding site [chemical binding]; other site 697303007408 Q-loop/lid; other site 697303007409 ABC transporter signature motif; other site 697303007410 Walker B; other site 697303007411 D-loop; other site 697303007412 H-loop/switch region; other site 697303007413 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697303007414 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 697303007415 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 697303007416 Walker A/P-loop; other site 697303007417 ATP binding site [chemical binding]; other site 697303007418 Q-loop/lid; other site 697303007419 ABC transporter signature motif; other site 697303007420 Walker B; other site 697303007421 D-loop; other site 697303007422 H-loop/switch region; other site 697303007423 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 697303007424 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303007425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303007426 Transposase IS200 like; Region: Y1_Tnp; cl00848 697303007427 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303007428 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 697303007429 ABC-2 type transporter; Region: ABC2_membrane; cl11417 697303007430 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 697303007431 ABC-2 type transporter; Region: ABC2_membrane; cl11417 697303007432 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007433 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 697303007434 Walker A/P-loop; other site 697303007435 ATP binding site [chemical binding]; other site 697303007436 Q-loop/lid; other site 697303007437 ABC transporter signature motif; other site 697303007438 Walker B; other site 697303007439 D-loop; other site 697303007440 H-loop/switch region; other site 697303007441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303007442 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 697303007443 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 697303007444 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 697303007445 active site 697303007446 HIGH motif; other site 697303007447 KMSK motif region; other site 697303007448 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 697303007449 tRNA binding surface [nucleotide binding]; other site 697303007450 anticodon binding site; other site 697303007451 Domain of unknown function (DUF1934); Region: DUF1934; cl01870 697303007452 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 697303007453 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 697303007454 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 697303007455 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 697303007456 germination protein YpeB; Region: spore_YpeB; TIGR02889 697303007457 Peptidase propeptide and YPEB domain; Region: PepSY; cl15480 697303007458 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 697303007459 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 697303007460 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 697303007461 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; cl09775 697303007462 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; cl05194 697303007463 Amino acid permease; Region: AA_permease; cl00524 697303007464 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 697303007465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 697303007466 active site 697303007467 Transcriptional regulators [Transcription]; Region: GntR; COG1802 697303007468 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 697303007469 DNA-binding site [nucleotide binding]; DNA binding site 697303007470 FCD domain; Region: FCD; cl11656 697303007471 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 697303007472 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 697303007473 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697303007474 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 697303007475 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 697303007476 Domain of unknown function (DUF3794); Region: DUF3794; pfam12673 697303007477 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303007478 putative peptidoglycan binding site; other site 697303007479 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 697303007480 YabG peptidase U57; Region: Peptidase_U57; cl05250 697303007481 stage V sporulation protein T; Region: spore_V_T; TIGR02851 697303007482 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 697303007483 SurA N-terminal domain; Region: SurA_N; pfam09312 697303007484 PPIC-type PPIASE domain; Region: Rotamase; cl08278 697303007485 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 697303007486 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 697303007487 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 697303007488 ATP binding site [chemical binding]; other site 697303007489 putative Mg++ binding site [ion binding]; other site 697303007490 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 697303007491 nucleotide binding region [chemical binding]; other site 697303007492 ATP-binding site [chemical binding]; other site 697303007493 TRCF domain; Region: TRCF; cl04088 697303007494 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 697303007495 putative active site [active] 697303007496 catalytic residue [active] 697303007497 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 697303007498 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697303007499 protein binding site [polypeptide binding]; other site 697303007500 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 697303007501 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303007502 dimerization interface [polypeptide binding]; other site 697303007503 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303007504 dimer interface [polypeptide binding]; other site 697303007505 phosphorylation site [posttranslational modification] 697303007506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303007507 ATP binding site [chemical binding]; other site 697303007508 Mg2+ binding site [ion binding]; other site 697303007509 G-X-G motif; other site 697303007510 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697303007511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303007512 active site 697303007513 phosphorylation site [posttranslational modification] 697303007514 intermolecular recognition site; other site 697303007515 dimerization interface [polypeptide binding]; other site 697303007516 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303007517 DNA binding site [nucleotide binding] 697303007518 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 697303007519 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303007520 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 697303007521 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 697303007522 Substrate binding site; other site 697303007523 Mg++ binding site; other site 697303007524 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 697303007525 active site 697303007526 substrate binding site [chemical binding]; other site 697303007527 CoA binding site [chemical binding]; other site 697303007528 SpoVG; Region: SpoVG; cl00915 697303007529 pur operon repressor; Provisional; Region: PRK09213 697303007530 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 697303007531 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 697303007532 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 697303007533 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 697303007534 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303007535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697303007536 Transcriptional regulators [Transcription]; Region: PurR; COG1609 697303007537 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 697303007538 DNA binding site [nucleotide binding] 697303007539 domain linker motif; other site 697303007540 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 697303007541 putative dimerization interface [polypeptide binding]; other site 697303007542 putative ligand binding site [chemical binding]; other site 697303007543 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 697303007544 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 697303007545 putative dimer interface [polypeptide binding]; other site 697303007546 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 697303007547 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 697303007548 P-loop; other site 697303007549 active site 697303007550 phosphorylation site [posttranslational modification] 697303007551 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; cl00557 697303007552 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 697303007553 active site 697303007554 phosphorylation site [posttranslational modification] 697303007555 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 697303007556 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 697303007557 putative substrate binding site [chemical binding]; other site 697303007558 putative ATP binding site [chemical binding]; other site 697303007559 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 697303007560 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl00088 697303007561 SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to...; Region: SugarP_isomerase; cl00339 697303007562 S-layer homology domain; Region: SLH; pfam00395 697303007563 S-layer homology domain; Region: SLH; pfam00395 697303007564 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; cl09200 697303007565 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303007566 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 697303007567 S-layer homology domain; Region: SLH; pfam00395 697303007568 S-layer homology domain; Region: SLH; pfam00395 697303007569 S-layer homology domain; Region: SLH; pfam00395 697303007570 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303007571 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 697303007572 Bacterial SH3 domain; Region: SH3_3; cl02551 697303007573 Alpha amylase, catalytic domain; Region: Alpha-amylase; cl07893 697303007574 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 697303007575 Phd_YefM; Region: PhdYeFM; cl09153 697303007576 CTP synthetase; Validated; Region: pyrG; PRK05380 697303007577 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 697303007578 Catalytic site [active] 697303007579 active site 697303007580 UTP binding site [chemical binding]; other site 697303007581 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 697303007582 active site 697303007583 putative oxyanion hole; other site 697303007584 catalytic triad [active] 697303007585 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 697303007586 histidinol-phosphatase; Provisional; Region: PRK07328 697303007587 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 697303007588 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 697303007589 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303007590 Beta-Casp domain; Region: Beta-Casp; cl12567 697303007591 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 697303007592 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 697303007593 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007594 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 697303007595 putative L-serine binding site [chemical binding]; other site 697303007596 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 697303007597 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 697303007598 homodimer interface [polypeptide binding]; other site 697303007599 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303007600 catalytic residue [active] 697303007601 Spc7 kinetochore protein; Region: Spc7; smart00787 697303007602 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 697303007603 putative active site [active] 697303007604 catalytic triad [active] 697303007605 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 697303007606 putative integrin binding motif; other site 697303007607 PA/protease domain interface [polypeptide binding]; other site 697303007608 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 697303007609 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 697303007610 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 697303007611 S-layer homology domain; Region: SLH; pfam00395 697303007612 S-layer homology domain; Region: SLH; pfam00395 697303007613 S-layer homology domain; Region: SLH; pfam00395 697303007614 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 697303007615 C-terminal peptidase (prc); Region: prc; TIGR00225 697303007616 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 697303007617 protein binding site [polypeptide binding]; other site 697303007618 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 697303007619 Catalytic dyad [active] 697303007620 Putative peptidoglycan binding domain; Region: PG_binding_1; cl15437 697303007621 homoserine kinase; Provisional; Region: PRK01212 697303007622 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 697303007623 threonine synthase; Reviewed; Region: PRK06721 697303007624 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 697303007625 homodimer interface [polypeptide binding]; other site 697303007626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 697303007627 catalytic residue [active] 697303007628 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007629 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 697303007630 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 697303007631 hypothetical protein; Provisional; Region: PRK04435 697303007632 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 697303007633 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303007634 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303007635 Amino acid permease; Region: AA_permease; cl00524 697303007636 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 697303007637 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303007638 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 697303007639 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 697303007640 active site 697303007641 FMN binding site [chemical binding]; other site 697303007642 substrate binding site [chemical binding]; other site 697303007643 putative catalytic residue [active] 697303007644 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007645 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 697303007646 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303007647 Walker A motif; other site 697303007648 ATP binding site [chemical binding]; other site 697303007649 Walker B motif; other site 697303007650 arginine finger; other site 697303007651 Integrase core domain; Region: rve; cl01316 697303007652 IS2 transposase TnpB; Reviewed; Region: PRK09409 697303007653 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 697303007654 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 697303007655 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 697303007656 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 697303007657 active site pocket [active] 697303007658 oxyanion hole [active] 697303007659 catalytic triad [active] 697303007660 active site nucleophile [active] 697303007661 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303007662 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303007663 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 697303007664 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007665 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 697303007666 CRISPR-associated protein Cas5, subtype I-B/HMARI; Region: cas_Cas5h; TIGR02592 697303007667 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 697303007668 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 697303007669 CRISPR/Cas system-associated protein Cas8a1; Region: Cas8a1_I-A; cd09730 697303007670 Transposase domain (DUF772); Region: DUF772; cl12084 697303007671 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303007672 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 697303007673 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 697303007674 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 697303007675 active site 697303007676 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 697303007677 trimerization site [polypeptide binding]; other site 697303007678 active site 697303007679 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 697303007680 Aminotransferase class-V; Region: Aminotran_5; pfam00266 697303007681 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303007682 catalytic residue [active] 697303007683 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 697303007684 FeS assembly protein SufB; Region: sufB; TIGR01980 697303007685 Uncharacterized protein family (UPF0051); Region: UPF0051; cl03223 697303007686 FeS assembly ATPase SufC; Region: sufC; TIGR01978 697303007687 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 697303007688 Walker A/P-loop; other site 697303007689 ATP binding site [chemical binding]; other site 697303007690 Q-loop/lid; other site 697303007691 ABC transporter signature motif; other site 697303007692 Walker B; other site 697303007693 D-loop; other site 697303007694 H-loop/switch region; other site 697303007695 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 697303007696 oligomerisation interface [polypeptide binding]; other site 697303007697 roof hairpin; other site 697303007698 Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187 697303007699 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 697303007700 catalytic residues [active] 697303007701 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 697303007702 catalytic residues [active] 697303007703 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 697303007704 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 697303007705 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 697303007706 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 697303007707 Probable transposase; Region: OrfB_IS605; pfam01385 697303007708 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697303007709 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 697303007710 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 697303007711 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 697303007712 active site 697303007713 HIGH motif; other site 697303007714 dimer interface [polypeptide binding]; other site 697303007715 KMSKS motif; other site 697303007716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 697303007717 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 697303007718 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 697303007719 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 697303007720 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 697303007721 protein binding site [polypeptide binding]; other site 697303007722 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 697303007723 hinge; other site 697303007724 active site 697303007725 YycH protein; Region: YycI; cl02015 697303007726 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 697303007727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303007728 dimerization interface [polypeptide binding]; other site 697303007729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 697303007730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 697303007731 dimer interface [polypeptide binding]; other site 697303007732 phosphorylation site [posttranslational modification] 697303007733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 697303007734 ATP binding site [chemical binding]; other site 697303007735 Mg2+ binding site [ion binding]; other site 697303007736 G-X-G motif; other site 697303007737 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 697303007738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 697303007739 active site 697303007740 phosphorylation site [posttranslational modification] 697303007741 intermolecular recognition site; other site 697303007742 dimerization interface [polypeptide binding]; other site 697303007743 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 697303007744 DNA binding site [nucleotide binding] 697303007745 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 697303007746 putative peptidoglycan binding site; other site 697303007747 G5 domain; Region: G5; pfam07501 697303007748 Peptidase family M23; Region: Peptidase_M23; pfam01551 697303007749 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 697303007750 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 697303007751 DNA replication protein DnaC; Validated; Region: PRK06835 697303007752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 697303007753 Walker A motif; other site 697303007754 ATP binding site [chemical binding]; other site 697303007755 Walker B motif; other site 697303007756 arginine finger; other site 697303007757 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 697303007758 Zn binding site [ion binding]; other site 697303007759 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 697303007760 Probable transposase; Region: OrfB_IS605; pfam01385 697303007761 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 697303007762 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 697303007763 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 697303007764 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 697303007765 dimer interface [polypeptide binding]; other site 697303007766 Transposase; Region: DEDD_Tnp_IS110; pfam01548 697303007767 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 697303007768 Iron permease FTR1 family; Region: FTR1; cl00475 697303007769 phage shock protein A; Region: phageshock_pspA; TIGR02977 697303007770 phosphodiesterase; Provisional; Region: PRK12704 697303007771 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 697303007772 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 697303007773 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 697303007774 GDP-binding site [chemical binding]; other site 697303007775 ACT binding site; other site 697303007776 IMP binding site; other site 697303007777 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 697303007778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007779 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 697303007780 dimerization interface [polypeptide binding]; other site 697303007781 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These transmembrane...; Region: TarH; cl00144 697303007782 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 697303007783 Uncharacterized conserved protein [Function unknown]; Region: COG1284 697303007784 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; cl10498 697303007785 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007786 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 697303007787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007788 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 697303007789 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 697303007790 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 697303007791 putative active site [active] 697303007792 putative metal binding site [ion binding]; other site 697303007793 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 697303007794 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 697303007795 putative active site [active] 697303007796 putative NTP binding site [chemical binding]; other site 697303007797 putative nucleic acid binding site [nucleotide binding]; other site 697303007798 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 697303007799 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 697303007800 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 697303007801 active site 697303007802 substrate binding site [chemical binding]; other site 697303007803 metal binding site [ion binding]; metal-binding site 697303007804 oligoendopeptidase F; Region: pepF; TIGR00181 697303007805 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_4; cd09609 697303007806 active site 697303007807 Zn binding site [ion binding]; other site 697303007808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl12011 697303007809 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303007810 S-adenosylmethionine binding site [chemical binding]; other site 697303007811 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 697303007812 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007813 Walker A/P-loop; other site 697303007814 ATP binding site [chemical binding]; other site 697303007815 Q-loop/lid; other site 697303007816 ABC transporter signature motif; other site 697303007817 Walker B; other site 697303007818 D-loop; other site 697303007819 H-loop/switch region; other site 697303007820 Protein of unknown function (DUF990); Region: DUF990; cl01496 697303007821 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 697303007822 Protein of unknown function (DUF990); Region: DUF990; cl01496 697303007823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697303007824 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 697303007825 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007826 Walker A/P-loop; other site 697303007827 ATP binding site [chemical binding]; other site 697303007828 Q-loop/lid; other site 697303007829 ABC transporter signature motif; other site 697303007830 Walker B; other site 697303007831 D-loop; other site 697303007832 H-loop/switch region; other site 697303007833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 697303007834 Major Facilitator Superfamily; Region: MFS_1; pfam07690 697303007835 putative substrate translocation pore; other site 697303007836 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 697303007837 non-specific DNA binding site [nucleotide binding]; other site 697303007838 salt bridge; other site 697303007839 sequence-specific DNA binding site [nucleotide binding]; other site 697303007840 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 697303007841 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697303007842 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 697303007843 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007844 Walker A/P-loop; other site 697303007845 ATP binding site [chemical binding]; other site 697303007846 Q-loop/lid; other site 697303007847 ABC transporter signature motif; other site 697303007848 Walker B; other site 697303007849 D-loop; other site 697303007850 H-loop/switch region; other site 697303007851 Transposase domain (DUF772); Region: DUF772; cl12084 697303007852 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 697303007853 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 697303007854 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 697303007855 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop_NTPase; cl09099 697303007856 Walker A/P-loop; other site 697303007857 ATP binding site [chemical binding]; other site 697303007858 Q-loop/lid; other site 697303007859 ABC transporter signature motif; other site 697303007860 Walker B; other site 697303007861 D-loop; other site 697303007862 H-loop/switch region; other site 697303007863 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 697303007864 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 697303007865 FeS/SAM binding site; other site 697303007866 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 697303007867 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 697303007868 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 697303007869 ligand binding site [chemical binding]; other site 697303007870 flexible hinge region; other site 697303007871 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 697303007872 putative switch regulator; other site 697303007873 non-specific DNA interactions [nucleotide binding]; other site 697303007874 DNA binding site [nucleotide binding] 697303007875 sequence specific DNA binding site [nucleotide binding]; other site 697303007876 putative cAMP binding site [chemical binding]; other site 697303007877 replicative DNA helicase; Region: DnaB; TIGR00665 697303007878 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 697303007879 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 697303007880 Walker A motif; other site 697303007881 ATP binding site [chemical binding]; other site 697303007882 Walker B motif; other site 697303007883 DNA binding loops [nucleotide binding] 697303007884 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 697303007885 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 697303007886 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 697303007887 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 697303007888 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 697303007889 dimer interface [polypeptide binding]; other site 697303007890 ssDNA binding site [nucleotide binding]; other site 697303007891 tetramer (dimer of dimers) interface [polypeptide binding]; other site 697303007892 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 697303007893 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 697303007894 Mechanosensitive ion channel; Region: MS_channel; pfam00924 697303007895 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 697303007896 cyanophycin synthetase; Region: cya_phycin_syn; TIGR02068 697303007897 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 697303007898 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 697303007899 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 697303007900 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 697303007901 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 697303007902 proposed catalytic triad [active] 697303007903 active site nucleophile [active] 697303007904 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 697303007905 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 697303007906 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 697303007907 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 697303007908 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 697303007909 catalytic residue [active] 697303007910 ParB-like partition proteins; Region: parB_part; TIGR00180 697303007911 ParB-like nuclease domain; Region: ParBc; cl02129 697303007912 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 697303007913 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 697303007914 P-loop; other site 697303007915 Magnesium ion binding site [ion binding]; other site 697303007916 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 697303007917 Magnesium ion binding site [ion binding]; other site 697303007918 ParB-like partition proteins; Region: parB_part; TIGR00180 697303007919 ParB-like nuclease domain; Region: ParBc; cl02129 697303007920 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 697303007921 nudix motif; other site 697303007922 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 697303007923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 697303007924 S-adenosylmethionine binding site [chemical binding]; other site 697303007925 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 697303007926 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 697303007927 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335; cl15440 697303007928 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 697303007929 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 697303007930 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 697303007931 G1 box; other site 697303007932 GTP/Mg2+ binding site [chemical binding]; other site 697303007933 Switch I region; other site 697303007934 G2 box; other site 697303007935 Switch II region; other site 697303007936 G3 box; other site 697303007937 G4 box; other site 697303007938 G5 box; other site 697303007939 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 697303007940 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 697303007941 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 697303007942 G-X-X-G motif; other site 697303007943 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 697303007944 RxxxH motif; other site 697303007945 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 697303007946 Domain of unknown function DUF37; Region: DUF37; cl00506 697303007947 Ribonuclease P; Region: Ribonuclease_P; cl00457