-- dump date 20111121_015336 -- class Genbank::misc_feature -- table misc_feature_note -- id note 667014000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 667014000002 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 667014000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014000004 Walker A motif; other site 667014000005 ATP binding site [chemical binding]; other site 667014000006 Walker B motif; other site 667014000007 arginine finger; other site 667014000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 667014000009 DnaA box-binding interface [nucleotide binding]; other site 667014000010 FAD binding domain; Region: FAD_binding_4; pfam01565 667014000011 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 667014000012 Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771 667014000013 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16...; Region: OM_channels; cl00284 667014000014 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 667014000015 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014000016 dimer interface [polypeptide binding]; other site 667014000017 phosphorylation site [posttranslational modification] 667014000018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014000019 ATP binding site [chemical binding]; other site 667014000020 Mg2+ binding site [ion binding]; other site 667014000021 G-X-G motif; other site 667014000022 Dehydratase family; Region: ILVD_EDD; cl00340 667014000023 dihydroxy-acid dehydratase; Region: ilvD; TIGR00110 667014000024 NifU-like domain; Region: NifU; cl00484 667014000025 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 667014000026 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 667014000027 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 667014000028 HSP70 interaction site [polypeptide binding]; other site 667014000029 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 667014000030 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 667014000031 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a...; Region: MoaC_PE; cd01420 667014000032 trimer interface [polypeptide binding]; other site 667014000033 dimer interface [polypeptide binding]; other site 667014000034 putative active site [active] 667014000035 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 667014000036 Alpha-amylase/alpha-mannosidase [Carbohydrate transport and metabolism]; Region: COG1449 667014000037 ADP-glucose phosphorylase; Region: PLN02643 667014000038 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 667014000039 dimer interface [polypeptide binding]; other site 667014000040 active site 667014000041 Response regulator receiver domain; Region: Response_reg; pfam00072 667014000042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000043 active site 667014000044 phosphorylation site [posttranslational modification] 667014000045 intermolecular recognition site; other site 667014000046 dimerization interface [polypeptide binding]; other site 667014000047 Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181 667014000048 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 667014000049 NAD binding site [chemical binding]; other site 667014000050 substrate binding site [chemical binding]; other site 667014000051 homodimer interface [polypeptide binding]; other site 667014000052 active site 667014000053 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 667014000054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014000055 Walker A motif; other site 667014000056 ATP binding site [chemical binding]; other site 667014000057 Walker B motif; other site 667014000058 arginine finger; other site 667014000059 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014000060 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 667014000061 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 667014000062 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 667014000063 homodimer interface [polypeptide binding]; other site 667014000064 oligonucleotide binding site [chemical binding]; other site 667014000065 CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step...; Region: CIMS_like; cd03310 667014000066 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014000067 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 667014000068 HSP70 interaction site [polypeptide binding]; other site 667014000069 Uncharacterized ACR, COG2106; Region: DUF171; cl12077 667014000070 HipA-like N-terminal domain; Region: HipA_N; pfam07805 667014000071 HipA-like C-terminal domain; Region: HipA_C; pfam07804 667014000072 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 667014000073 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 667014000074 Major Facilitator Superfamily; Region: MFS_1; pfam07690 667014000075 putative substrate translocation pore; other site 667014000076 phosphoenolpyruvate synthase; Validated; Region: PRK06464 667014000077 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 667014000078 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 667014000079 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 667014000080 Uncharacterized protein conserved in archaea (DUF2250); Region: DUF2250; pfam10007 667014000081 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]; Region: BioF; COG0156 667014000082 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-...; Region: KBL_like; cd06454 667014000083 substrate-cofactor binding pocket; other site 667014000084 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014000085 catalytic residue [active] 667014000086 adenosylmethionine--8-amino-7-oxononanoate transaminase; Provisional; Region: PRK05964 667014000087 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 667014000088 inhibitor-cofactor binding pocket; inhibition site 667014000089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014000090 catalytic residue [active] 667014000091 biotin synthetase; Region: bioB; TIGR00433 667014000092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014000093 FeS/SAM binding site; other site 667014000094 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 667014000095 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 667014000096 Putative zinc ribbon domain; Region: DUF164; pfam02591 667014000097 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014000098 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014000099 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014000100 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 667014000101 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 667014000102 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 667014000103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 667014000104 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 667014000105 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 667014000106 DNA binding residues [nucleotide binding] 667014000107 DNA primase, catalytic core; Region: dnaG; TIGR01391 667014000108 CHC2 zinc finger; Region: zf-CHC2; cl02597 667014000109 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 667014000110 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 667014000111 active site 667014000112 metal binding site [ion binding]; metal-binding site 667014000113 interdomain interaction site; other site 667014000114 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 667014000115 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 667014000116 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014000117 Walker A/P-loop; other site 667014000118 ATP binding site [chemical binding]; other site 667014000119 Q-loop/lid; other site 667014000120 ABC transporter signature motif; other site 667014000121 Walker B; other site 667014000122 D-loop; other site 667014000123 H-loop/switch region; other site 667014000124 Smr domain; Region: Smr; cl02619 667014000125 Ribosomal protein S21; Region: Ribosomal_S21; cl00529 667014000126 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 667014000127 SUA5 domain; Region: SUA5; pfam03481 667014000128 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active...; Region: 4HBT; cd00586 667014000129 active site 667014000130 16S rRNA methyltransferase B; Provisional; Region: PRK14902 667014000131 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the rRNA-...; Region: NusB_Sun; cl00223 667014000132 putative RNA binding site [nucleotide binding]; other site 667014000133 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014000134 S-adenosylmethionine binding site [chemical binding]; other site 667014000135 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014000136 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 667014000137 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014000138 S-adenosylmethionine binding site [chemical binding]; other site 667014000139 tyrosine aminotransferase, eukaryotic; Region: tyr_amTase_E; TIGR01264 667014000140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 667014000141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014000142 homodimer interface [polypeptide binding]; other site 667014000143 catalytic residue [active] 667014000144 Nucleoside recognition; Region: Gate; cl00486 667014000145 Nucleoside recognition; Region: Gate; cl00486 667014000146 AIR carboxylase; Region: AIRC; cl00310 667014000147 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 667014000148 Ion channel; Region: Ion_trans_2; cl11596 667014000149 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 667014000150 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014000151 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014000152 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 667014000153 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 667014000154 active site 667014000155 dimer interface [polypeptide binding]; other site 667014000156 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 667014000157 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014000158 glycosylphosphatidylinositol-specific phospholipase C; Provisional; Region: PTZ00268 667014000159 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 667014000160 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 667014000161 CPxP motif; other site 667014000162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014000163 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 667014000164 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 667014000165 putative dimerization interface [polypeptide binding]; other site 667014000166 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 667014000167 putative active site [active] 667014000168 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 667014000169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014000170 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 667014000171 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 667014000172 inhibitor-cofactor binding pocket; inhibition site 667014000173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014000174 catalytic residue [active] 667014000175 Radical SAM; Region: Elp3; smart00729 667014000176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014000177 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 667014000178 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 667014000179 Clostridium kluyveri Re-citrate synthase and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_Re_CS; cd07947 667014000180 active site 667014000181 catalytic residues [active] 667014000182 metal binding site [ion binding]; metal-binding site 667014000183 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 667014000184 Alkaline phosphatase homologues; Region: alkPPc; smart00098 667014000185 active site 667014000186 dimer interface [polypeptide binding]; other site 667014000187 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 667014000188 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 667014000189 DNA polymerase III, delta subunit; Region: holA; TIGR01128 667014000190 PRTRC system ParB family protein; Region: PRTRC_parB; TIGR03734 667014000191 ParB-like nuclease domain; Region: ParBc; cl02129 667014000192 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 667014000193 ATP binding site [chemical binding]; other site 667014000194 active site 667014000195 substrate binding site [chemical binding]; other site 667014000196 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 667014000197 MgtC family; Region: MgtC; cl12207 667014000198 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14314 667014000199 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of UDP-N-...; Region: GlmM; cd05802 667014000200 active site 667014000201 substrate binding site [chemical binding]; other site 667014000202 metal binding site [ion binding]; metal-binding site 667014000203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 667014000204 YbbR-like protein; Region: YbbR; pfam07949 667014000205 Uncharacterized conserved protein [Function unknown]; Region: COG1624 667014000206 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 667014000207 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 667014000208 dihydropteroate synthase; Region: DHPS; TIGR01496 667014000209 substrate binding pocket [chemical binding]; other site 667014000210 dimer interface [polypeptide binding]; other site 667014000211 inhibitor binding site; inhibition site 667014000212 FtsH Extracellular; Region: FtsH_ext; pfam06480 667014000213 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 667014000214 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014000215 Walker A motif; other site 667014000216 ATP binding site [chemical binding]; other site 667014000217 Walker B motif; other site 667014000218 arginine finger; other site 667014000219 Peptidase family M41; Region: Peptidase_M41; pfam01434 667014000220 Response regulator receiver domain; Region: Response_reg; pfam00072 667014000221 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000222 active site 667014000223 phosphorylation site [posttranslational modification] 667014000224 intermolecular recognition site; other site 667014000225 dimerization interface [polypeptide binding]; other site 667014000226 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014000227 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 667014000228 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014000229 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014000230 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 667014000231 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 667014000232 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 667014000233 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 667014000234 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 667014000235 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 667014000236 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and...; Region: GMPK; cd00071 667014000237 catalytic site [active] 667014000238 G-X2-G-X-G-K; other site 667014000239 Domain of unknown function (DUF370); Region: DUF370; cl00898 667014000240 hypothetical protein; Provisional; Region: PRK11820 667014000241 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 667014000242 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 667014000243 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 667014000244 ligand binding site [chemical binding]; other site 667014000245 periplasmic chaperone; Provisional; Region: PRK10780 667014000246 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 667014000247 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 667014000248 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 667014000249 MviN-like protein; Region: MVIN; pfam03023 667014000250 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 667014000251 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 667014000252 indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336 667014000253 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 667014000254 dimer interface [polypeptide binding]; other site 667014000255 PYR/PP interface [polypeptide binding]; other site 667014000256 TPP binding site [chemical binding]; other site 667014000257 substrate binding site [chemical binding]; other site 667014000258 TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as indolepyruvate or phenylpyruvate, which are generated by the...; Region: TPP_IOR_alpha; cd02008 667014000259 TPP-binding site; other site 667014000260 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 667014000261 metal binding site 2 [ion binding]; metal-binding site 667014000262 putative DNA binding helix; other site 667014000263 metal binding site 1 [ion binding]; metal-binding site 667014000264 dimer interface [polypeptide binding]; other site 667014000265 structural Zn2+ binding site [ion binding]; other site 667014000266 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014000267 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014000268 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 667014000269 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 667014000270 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 667014000271 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014000272 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 667014000273 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 667014000274 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 667014000275 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 667014000276 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 667014000277 DsrE/DsrF-like family; Region: DrsE; cl00672 667014000278 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 667014000279 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014000280 Cysteine-rich domain; Region: CCG; pfam02754 667014000281 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014000282 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 667014000283 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 667014000284 homodimer interface [polypeptide binding]; other site 667014000285 putative active site [active] 667014000286 catalytic site [active] 667014000287 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014000288 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 667014000289 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 667014000290 nucleotide binding region [chemical binding]; other site 667014000291 ATP-binding site [chemical binding]; other site 667014000292 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 667014000293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014000294 S-adenosylmethionine binding site [chemical binding]; other site 667014000295 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 667014000296 Tetramer interface [polypeptide binding]; other site 667014000297 Active site [active] 667014000298 FMN-binding site [chemical binding]; other site 667014000299 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 667014000300 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 667014000301 ligand binding site [chemical binding]; other site 667014000302 flexible hinge region; other site 667014000303 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 667014000304 putative switch regulator; other site 667014000305 non-specific DNA interactions [nucleotide binding]; other site 667014000306 DNA binding site [nucleotide binding] 667014000307 sequence specific DNA binding site [nucleotide binding]; other site 667014000308 putative cAMP binding site [chemical binding]; other site 667014000309 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 667014000310 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 667014000311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014000312 dimer interface [polypeptide binding]; other site 667014000313 conserved gate region; other site 667014000314 putative PBP binding loops; other site 667014000315 ABC-ATPase subunit interface; other site 667014000316 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 667014000317 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014000318 dimer interface [polypeptide binding]; other site 667014000319 conserved gate region; other site 667014000320 putative PBP binding loops; other site 667014000321 ABC-ATPase subunit interface; other site 667014000322 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 667014000323 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 667014000324 putative dimer interface [polypeptide binding]; other site 667014000325 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 667014000326 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 667014000327 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cl02542 667014000328 anaerobic ribonucleoside-triphosphate reductase; Region: NrdD; TIGR02487 667014000329 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270 667014000330 ATP cone domain; Region: ATP-cone; pfam03477 667014000331 Class III ribonucleotide reductase; Region: RNR_III; cd01675 667014000332 effector binding site; other site 667014000333 active site 667014000334 Zn binding site [ion binding]; other site 667014000335 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 667014000336 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 667014000337 intersubunit interface [polypeptide binding]; other site 667014000338 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 667014000339 active site 667014000340 metal binding site [ion binding]; metal-binding site 667014000341 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 667014000342 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014000343 sensory histidine kinase AtoS; Provisional; Region: PRK11360 667014000344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014000345 ATP binding site [chemical binding]; other site 667014000346 Mg2+ binding site [ion binding]; other site 667014000347 G-X-G motif; other site 667014000348 Acyl transferase domain; Region: Acyl_transf_1; cl08282 667014000349 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 667014000350 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and L-...; Region: GCS_H; cd06848 667014000351 lipoyl attachment site [posttranslational modification]; other site 667014000352 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 667014000353 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014000354 FeS/SAM binding site; other site 667014000355 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 667014000356 Trm112p-like protein; Region: Trm112p; cl01066 667014000357 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 667014000358 Protein export membrane protein; Region: SecD_SecF; cl14618 667014000359 Cupin domain; Region: Cupin_2; cl09118 667014000360 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 667014000361 Protein of unknown function (DUF2605); Region: DUF2605; pfam10792 667014000362 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 667014000363 E3 interaction surface; other site 667014000364 lipoyl attachment site [posttranslational modification]; other site 667014000365 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 667014000366 Outer membrane efflux protein; Region: OEP; pfam02321 667014000367 Outer membrane efflux protein; Region: OEP; pfam02321 667014000368 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 667014000369 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 667014000370 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 667014000371 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014000372 binding surface 667014000373 TPR motif; other site 667014000374 Urea transporter; Region: UT; cl01829 667014000375 Peptidase family M23; Region: Peptidase_M23; pfam01551 667014000376 diaminopimelate decarboxylase; Region: lysA; TIGR01048 667014000377 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme MccE; Region: PLPDE_III_MccE_like; cd06841 667014000378 dimer interface [polypeptide binding]; other site 667014000379 active site 667014000380 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 667014000381 catalytic residues [active] 667014000382 substrate binding site [chemical binding]; other site 667014000383 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 667014000384 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014000385 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 667014000386 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 667014000387 RNA binding site [nucleotide binding]; other site 667014000388 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 667014000389 RNA binding site [nucleotide binding]; other site 667014000390 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 667014000391 RNA binding site [nucleotide binding]; other site 667014000392 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 667014000393 RNA binding site [nucleotide binding]; other site 667014000394 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists of...; Region: S1_RPS1_repeat_ec3; cd05688 667014000395 RNA binding site [nucleotide binding]; other site 667014000396 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 667014000397 RNA binding site [nucleotide binding]; other site 667014000398 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 667014000399 tandem repeat interface [polypeptide binding]; other site 667014000400 oligomer interface [polypeptide binding]; other site 667014000401 active site residues [active] 667014000402 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 667014000403 IHF dimer interface [polypeptide binding]; other site 667014000404 IHF - DNA interface [nucleotide binding]; other site 667014000405 exopolyphosphatase; Region: exo_poly_only; TIGR03706 667014000406 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 667014000407 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 667014000408 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 667014000409 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a key...; Region: CBS_pair_IMPDH; cd04601 667014000410 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of the...; Region: IMPDH; cd00381 667014000411 active site 667014000412 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 667014000413 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 667014000414 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 667014000415 Protein of unknown function (DUF434); Region: DUF434; cl04460 667014000416 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 667014000417 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 667014000418 HSP70 interaction site [polypeptide binding]; other site 667014000419 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 667014000420 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 667014000421 3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519 667014000422 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 667014000423 acetyl-CoA synthetase; Provisional; Region: PRK00174 667014000424 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 667014000425 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 667014000426 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 667014000427 ACT domain-containing protein [General function prediction only]; Region: COG4747 667014000428 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 667014000429 C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882 667014000430 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 667014000431 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 667014000432 nucleotide binding pocket [chemical binding]; other site 667014000433 K-X-D-G motif; other site 667014000434 catalytic site [active] 667014000435 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 667014000436 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 667014000437 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 667014000438 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo/...; Region: BRCT; cd00027 667014000439 Dimer interface [polypeptide binding]; other site 667014000440 BRCT sequence motif; other site 667014000441 YceG-like family; Region: YceG; pfam02618 667014000442 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 667014000443 dimerization interface [polypeptide binding]; other site 667014000444 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014000445 TPR motif; other site 667014000446 binding surface 667014000447 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014000448 binding surface 667014000449 TPR motif; other site 667014000450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014000451 binding surface 667014000452 TPR motif; other site 667014000453 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 667014000454 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014000455 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 667014000456 DNA binding residues [nucleotide binding] 667014000457 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 667014000458 Competence protein; Region: Competence; cl00471 667014000459 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014000460 Archease protein family (DUF101/UPF0211); Region: Archease; cl00606 667014000461 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 667014000462 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 667014000463 Protein export membrane protein; Region: SecD_SecF; cl14618 667014000464 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 667014000465 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014000466 Protein export membrane protein; Region: SecD_SecF; cl14618 667014000467 lon-related putative ATP-dependent protease; Region: lon_rel; TIGR00764 667014000468 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 667014000469 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 667014000470 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014000471 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014000472 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 667014000473 domain; Region: GreA_GreB_N; pfam03449 667014000474 C-term; Region: GreA_GreB; pfam01272 667014000475 UbiA prenyltransferase family; Region: UbiA; cl00337 667014000476 aromatic acid decarboxylase; Validated; Region: PRK05920 667014000477 Flavoprotein; Region: Flavoprotein; cl08021 667014000478 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 667014000479 intersubunit interface [polypeptide binding]; other site 667014000480 active site 667014000481 catalytic residue [active] 667014000482 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 667014000483 RNA/DNA hybrid binding site [nucleotide binding]; other site 667014000484 active site 667014000485 precorrin-2 dehydrogenase; Validated; Region: PRK06719 667014000486 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 667014000487 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 667014000488 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 667014000489 DNA binding site [nucleotide binding] 667014000490 active site 667014000491 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 667014000492 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 667014000493 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 667014000494 flagellar motor switch protein; Validated; Region: fliN; PRK05698 667014000495 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 667014000496 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 667014000497 FliP family; Region: FliP; cl00593 667014000498 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 667014000499 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 667014000500 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 667014000501 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 667014000502 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 667014000503 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 667014000504 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 667014000505 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014000506 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 667014000507 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 667014000508 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014000509 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 667014000510 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 667014000511 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 667014000512 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 667014000513 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 667014000514 DNA binding residues [nucleotide binding] 667014000515 Response regulator receiver domain; Region: Response_reg; pfam00072 667014000516 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000517 active site 667014000518 phosphorylation site [posttranslational modification] 667014000519 intermolecular recognition site; other site 667014000520 dimerization interface [polypeptide binding]; other site 667014000521 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014000522 Rrf2 family protein; Region: rrf2_super; TIGR00738 667014000523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014000524 ATP binding site [chemical binding]; other site 667014000525 Mg2+ binding site [ion binding]; other site 667014000526 G-X-G motif; other site 667014000527 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 667014000528 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 667014000529 Sulfatase; Region: Sulfatase; cl10460 667014000530 L-aspartate oxidase; Provisional; Region: PRK09077 667014000531 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014000532 domain; Region: Succ_DH_flav_C; pfam02910 667014000533 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 667014000534 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014000535 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 667014000536 HflX subfamily. A distinct conserved domain with a glycine-rich segment N-terminal of the GTPase domain characterizes the HflX subfamily. The E. coli HflX has been implicated in the control of the lambda cII repressor proteolysis, but the actual...; Region: HflX; cd01878 667014000537 G1 box; other site 667014000538 GTP/Mg2+ binding site [chemical binding]; other site 667014000539 Switch I region; other site 667014000540 G2 box; other site 667014000541 G3 box; other site 667014000542 Switch II region; other site 667014000543 G4 box; other site 667014000544 G5 box; other site 667014000545 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 667014000546 PseudoU_synth_EcTruB: Pseudouridine synthase, Escherichia coli TruB like. This group consists of bacterial pseudouridine synthases similar to E. coli TruB and Mycobacterium tuberculosis TruB. Pseudouridine synthases catalyze the isomerization of...; Region: PseudoU_synth_EcTruB; cd02573 667014000547 RNA binding site [nucleotide binding]; other site 667014000548 active site 667014000549 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 667014000550 DHH family; Region: DHH; pfam01368 667014000551 Ribosome-binding factor A; Region: RBFA; cl00542 667014000552 Protein of unknown function (DUF503); Region: DUF503; cl00669 667014000553 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 667014000554 translation initiation factor IF-2; Region: IF-2; TIGR00487 667014000555 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 667014000556 IF2/eIF5B (initiation factors 2/ eukaryotic initiation factor 5B) subfamily. IF2/eIF5B contribute to ribosomal subunit joining and function as GTPases that are maximally activated by the presence of both ribosomal subunits. As seen in other GTPases...; Region: IF2_eIF5B; cd01887 667014000557 G1 box; other site 667014000558 putative GEF interaction site [polypeptide binding]; other site 667014000559 GTP/Mg2+ binding site [chemical binding]; other site 667014000560 Switch I region; other site 667014000561 G2 box; other site 667014000562 G3 box; other site 667014000563 Switch II region; other site 667014000564 G4 box; other site 667014000565 G5 box; other site 667014000566 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the...; Region: IF2_mtIF2_II; cd03702 667014000567 Translation-initiation factor 2; Region: IF-2; pfam11987 667014000568 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation...; Region: mtIF2_IVc; cd03692 667014000569 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cl00189 667014000570 putative RNA binding cleft [nucleotide binding]; other site 667014000571 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 667014000572 NusA N-terminal domain; Region: NusA_N; pfam08529 667014000573 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and...; Region: S1_NusA; cd04455 667014000574 RNA binding site [nucleotide binding]; other site 667014000575 homodimer interface [polypeptide binding]; other site 667014000576 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 667014000577 G-X-X-G motif; other site 667014000578 DNA repair and recombination protein RadA; Validated; Region: radA; PRK04301 667014000579 ribosome maturation protein RimP; Reviewed; Region: PRK00092 667014000580 YxlS is a Bacillus subtilis gene of unknown function with two domains that each have an alpha/beta fold. The N-terminal domain is composed of two alpha-helices and a three-stranded beta-sheet, while the C-terminal domain is composed of one alpha-helix...; Region: YlxS_C; cd01734 667014000581 Sm1 motif; other site 667014000582 predicted subunit interaction site [polypeptide binding]; other site 667014000583 RNA binding pocket [nucleotide binding]; other site 667014000584 Sm2 motif; other site 667014000585 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014000586 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 667014000587 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 667014000588 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 667014000589 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 667014000590 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701 667014000591 CRISPR-associated protein, Csx11 family; Region: cas_csx11; TIGR02682 667014000592 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 667014000593 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 667014000594 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4871 667014000595 Putative Fe-S cluster; Region: FeS; pfam04060 667014000596 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09687 667014000597 CRISPR-associated protein Cas5, subtype I-B/TNEAP; Region: cas_Cas5t; TIGR01895 667014000598 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cd09693 667014000599 CRISPR/Cas system-associated protein Cas3''; Region: Cas3''_I; cd09641 667014000600 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014000601 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 667014000602 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 667014000603 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 667014000604 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722 667014000605 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 667014000606 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014000607 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014000608 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 667014000609 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 667014000610 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 667014000611 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 667014000612 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 667014000613 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 667014000614 ribonuclease R; Region: RNase_R; TIGR02063 667014000615 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 667014000616 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain...; Region: S1_like; cl09927 667014000617 RNB domain; Region: RNB; pfam00773 667014000618 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase play an...; Region: S1_RNase_R; cd04471 667014000619 RNA binding site [nucleotide binding]; other site 667014000620 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 667014000621 nucleotide binding site/active site [active] 667014000622 HIT family signature motif; other site 667014000623 catalytic residue [active] 667014000624 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cl12032 667014000625 hypothetical protein; Reviewed; Region: PRK09588 667014000626 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(...; Region: Pep_deformylase; cd00487 667014000627 active site 667014000628 catalytic residues [active] 667014000629 metal binding site [ion binding]; metal-binding site 667014000630 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 667014000631 TM-ABC transporter signature motif; other site 667014000632 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 667014000633 TM-ABC transporter signature motif; other site 667014000634 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 667014000635 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 667014000636 putative ligand binding site [chemical binding]; other site 667014000637 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 667014000638 isocitrate dehydrogenase; Validated; Region: PRK06451 667014000639 ThiC family; Region: ThiC; cl08031 667014000640 Uncharacterized conserved protein [Function unknown]; Region: COG4715 667014000641 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 667014000642 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 667014000643 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 667014000644 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 667014000645 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014000646 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 667014000647 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 667014000648 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014000649 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 667014000650 IMP binding site; other site 667014000651 dimer interface [polypeptide binding]; other site 667014000652 interdomain contacts; other site 667014000653 partial ornithine binding site; other site 667014000654 periplasmic folding chaperone; Provisional; Region: PRK10788 667014000655 SurA N-terminal domain; Region: SurA_N; pfam09312 667014000656 PPIC-type PPIASE domain; Region: Rotamase; cl08278 667014000657 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 667014000658 PAS domain S-box; Region: sensory_box; TIGR00229 667014000659 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014000660 putative active site [active] 667014000661 heme pocket [chemical binding]; other site 667014000662 PAS fold; Region: PAS_4; pfam08448 667014000663 sensory histidine kinase AtoS; Provisional; Region: PRK11360 667014000664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014000665 ATP binding site [chemical binding]; other site 667014000666 Mg2+ binding site [ion binding]; other site 667014000667 G-X-G motif; other site 667014000668 Response regulator receiver domain; Region: Response_reg; pfam00072 667014000669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000670 active site 667014000671 phosphorylation site [posttranslational modification] 667014000672 intermolecular recognition site; other site 667014000673 dimerization interface [polypeptide binding]; other site 667014000674 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 667014000675 putative acyl-acceptor binding pocket; other site 667014000676 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 667014000677 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 667014000678 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014000679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014000680 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 667014000681 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014000682 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 667014000683 substrate binding site [chemical binding]; other site 667014000684 dimer interface [polypeptide binding]; other site 667014000685 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 667014000686 Active_site [active] 667014000687 UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773 667014000688 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 667014000689 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 667014000690 AsmA family; Region: AsmA; pfam05170 667014000691 DNA ligase D, 3'-phosphoesterase domain; Region: LigD_PE_dom; TIGR02777 667014000692 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 667014000693 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014000694 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 667014000695 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 667014000696 metal binding site [ion binding]; metal-binding site 667014000697 active site 667014000698 I-site; other site 667014000699 DNA-directed RNA polymerase subunit gamma; Provisional; Region: rpoC1; PRK02625 667014000700 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 667014000701 RNA polymerase Rpb1, domain 2; Region: RNA_pol_Rpb1_2; cl11591 667014000702 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 667014000703 DNA-directed RNA polymerase subunit beta'; Provisional; Region: rpoC2; PRK02597 667014000704 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 667014000705 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 667014000706 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 667014000707 bifunctional DNA-directed RNA polymerase subunit beta/beta'; Reviewed; Region: PRK09603 667014000708 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 667014000709 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 667014000710 DNA binding site [nucleotide binding] 667014000711 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 667014000712 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl04593 667014000713 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; cl04591 667014000714 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 667014000715 RPB11 interaction site [polypeptide binding]; other site 667014000716 RPB12 interaction site [polypeptide binding]; other site 667014000717 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 667014000718 RPB3 interaction site [polypeptide binding]; other site 667014000719 RPB1 interaction site [polypeptide binding]; other site 667014000720 RPB11 interaction site [polypeptide binding]; other site 667014000721 RPB10 interaction site [polypeptide binding]; other site 667014000722 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 667014000723 peripheral dimer interface [polypeptide binding]; other site 667014000724 core dimer interface [polypeptide binding]; other site 667014000725 L10 interface [polypeptide binding]; other site 667014000726 L11 interface [polypeptide binding]; other site 667014000727 putative EF-Tu interaction site [polypeptide binding]; other site 667014000728 putative EF-G interaction site [polypeptide binding]; other site 667014000729 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11...; Region: Ribosomal_L10; cd05797 667014000730 23S rRNA interface [nucleotide binding]; other site 667014000731 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 667014000732 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that...; Region: Ribosomal_L1; cd00403 667014000733 mRNA/rRNA interface [nucleotide binding]; other site 667014000734 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 667014000735 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 667014000736 23S rRNA interface [nucleotide binding]; other site 667014000737 L7/L12 interface [polypeptide binding]; other site 667014000738 putative thiostrepton binding site; other site 667014000739 L25 interface [polypeptide binding]; other site 667014000740 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 667014000741 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 667014000742 putative homodimer interface [polypeptide binding]; other site 667014000743 KOW motif; Region: KOW; cl00354 667014000744 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; cl00481 667014000745 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 667014000746 elongation factor Tu; Reviewed; Region: PRK00049 667014000747 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 667014000748 G1 box; other site 667014000749 GEF interaction site [polypeptide binding]; other site 667014000750 GTP/Mg2+ binding site [chemical binding]; other site 667014000751 Switch I region; other site 667014000752 G2 box; other site 667014000753 G3 box; other site 667014000754 Switch II region; other site 667014000755 G4 box; other site 667014000756 G5 box; other site 667014000757 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 667014000758 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 667014000759 Antibiotic Binding Site [chemical binding]; other site 667014000760 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 667014000761 tricarballylate utilization protein B; Provisional; Region: PRK15033 667014000762 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 667014000763 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014000764 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014000765 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014000766 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 667014000767 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014000768 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014000769 adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854 667014000770 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014000771 domain; Region: Succ_DH_flav_C; pfam02910 667014000772 adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060 667014000773 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 667014000774 Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139 667014000775 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 667014000776 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 667014000777 GTP binding site [chemical binding]; other site 667014000778 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 667014000779 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 667014000780 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 667014000781 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 667014000782 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase...; Region: H2MP_MemB-H2up; cd06062 667014000783 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 667014000784 putative substrate-binding site; other site 667014000785 nickel binding site [ion binding]; other site 667014000786 HupF/HypC family; Region: HupF_HypC; cl00394 667014000787 Hydrogenase expression/synthesis hypA family; Region: HypA; cl00418 667014000788 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014000789 Acylphosphatase; Region: Acylphosphatase; cl00551 667014000790 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 667014000791 HypF finger; Region: zf-HYPF; pfam07503 667014000792 HypF finger; Region: zf-HYPF; pfam07503 667014000793 yrdC domain; Region: Sua5_yciO_yrdC; cl00305 667014000794 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 667014000795 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 667014000796 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 667014000797 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014000798 FeS/SAM binding site; other site 667014000799 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 667014000800 tetramerization interface [polypeptide binding]; other site 667014000801 active site 667014000802 pantoate--beta-alanine ligase; Region: panC; TIGR00018 667014000803 Pantoate-beta-alanine ligase; Region: PanC; cd00560 667014000804 active site 667014000805 ATP-binding site [chemical binding]; other site 667014000806 pantoate-binding site; other site 667014000807 HXXH motif; other site 667014000808 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 667014000809 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 667014000810 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 667014000811 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 667014000812 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 667014000813 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014000814 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 667014000815 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 667014000816 active site 667014000817 catalytic residues [active] 667014000818 metal binding site [ion binding]; metal-binding site 667014000819 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 667014000820 aspartate kinase; Reviewed; Region: PRK06635 667014000821 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 667014000822 putative nucleotide binding site [chemical binding]; other site 667014000823 putative catalytic residues [active] 667014000824 putative Mg ion binding site [ion binding]; other site 667014000825 putative aspartate binding site [chemical binding]; other site 667014000826 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 667014000827 putative allosteric regulatory site; other site 667014000828 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 667014000829 putative allosteric regulatory residue; other site 667014000830 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 667014000831 HSP70 interaction site [polypeptide binding]; other site 667014000832 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014000833 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 667014000834 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 667014000835 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 667014000836 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014000837 Walker A/P-loop; other site 667014000838 ATP binding site [chemical binding]; other site 667014000839 Q-loop/lid; other site 667014000840 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 667014000841 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014000842 Walker A/P-loop; other site 667014000843 ATP binding site [chemical binding]; other site 667014000844 Q-loop/lid; other site 667014000845 ABC transporter signature motif; other site 667014000846 Walker B; other site 667014000847 D-loop; other site 667014000848 H-loop/switch region; other site 667014000849 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 667014000850 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 667014000851 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014000852 FeS/SAM binding site; other site 667014000853 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014000854 binding surface 667014000855 TPR motif; other site 667014000856 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 667014000857 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014000858 FeS/SAM binding site; other site 667014000859 PilZ domain; Region: PilZ; cl01260 667014000860 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 667014000861 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 667014000862 ligand binding site [chemical binding]; other site 667014000863 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 667014000864 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative...; Region: RPE; cd00429 667014000865 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 667014000866 substrate binding site [chemical binding]; other site 667014000867 hexamer interface [polypeptide binding]; other site 667014000868 metal binding site [ion binding]; metal-binding site 667014000869 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 667014000870 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 667014000871 dimerization interface [polypeptide binding]; other site 667014000872 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 667014000873 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014000874 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 667014000875 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014000876 ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998 667014000877 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014000878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014000879 dimer interface [polypeptide binding]; other site 667014000880 conserved gate region; other site 667014000881 putative PBP binding loops; other site 667014000882 ABC-ATPase subunit interface; other site 667014000883 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 667014000884 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 667014000885 Walker A/P-loop; other site 667014000886 ATP binding site [chemical binding]; other site 667014000887 Q-loop/lid; other site 667014000888 ABC transporter signature motif; other site 667014000889 Walker B; other site 667014000890 D-loop; other site 667014000891 H-loop/switch region; other site 667014000892 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 667014000893 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014000894 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000895 active site 667014000896 phosphorylation site [posttranslational modification] 667014000897 intermolecular recognition site; other site 667014000898 dimerization interface [polypeptide binding]; other site 667014000899 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014000900 Walker A motif; other site 667014000901 ATP binding site [chemical binding]; other site 667014000902 Walker B motif; other site 667014000903 arginine finger; other site 667014000904 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014000905 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 667014000906 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 667014000907 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014000908 dimer interface [polypeptide binding]; other site 667014000909 phosphorylation site [posttranslational modification] 667014000910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014000911 ATP binding site [chemical binding]; other site 667014000912 Mg2+ binding site [ion binding]; other site 667014000913 G-X-G motif; other site 667014000914 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 667014000915 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 667014000916 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014000917 Ligand Binding Site [chemical binding]; other site 667014000918 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 667014000919 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 667014000920 Citrate transporter; Region: CitMHS; pfam03600 667014000921 transmembrane helices; other site 667014000922 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014000923 Ligand Binding Site [chemical binding]; other site 667014000924 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014000925 Ligand Binding Site [chemical binding]; other site 667014000926 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 667014000927 Citrate transporter; Region: CitMHS; pfam03600 667014000928 transmembrane helices; other site 667014000929 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014000930 Ligand Binding Site [chemical binding]; other site 667014000931 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014000932 Ligand Binding Site [chemical binding]; other site 667014000933 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 667014000934 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 667014000935 DHHA2 domain; Region: DHHA2; pfam02833 667014000936 Phosphate-starvation-inducible E; Region: PsiE; cl01264 667014000937 membrane glycoprotein; Provisional; Region: PHA03332 667014000938 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 667014000939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014000940 ATP binding site [chemical binding]; other site 667014000941 Mg2+ binding site [ion binding]; other site 667014000942 G-X-G motif; other site 667014000943 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 667014000944 ATP binding site [chemical binding]; other site 667014000945 MutL C terminal dimerisation domain; Region: MutL_C; cl07336 667014000946 IPP transferase; Region: IPPT; cl00403 667014000947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 667014000948 metal binding site [ion binding]; metal-binding site 667014000949 active site 667014000950 I-site; other site 667014000951 Protein of unknown function DUF89; Region: DUF89; pfam01937 667014000952 Uncharacterized conserved protein [Function unknown]; Region: COG1578 667014000953 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 667014000954 active site 667014000955 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 667014000956 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 667014000957 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 667014000958 HSP70 interaction site [polypeptide binding]; other site 667014000959 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 667014000960 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 667014000961 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 667014000962 putative binding surface; other site 667014000963 active site 667014000964 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 667014000965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014000966 ATP binding site [chemical binding]; other site 667014000967 Mg2+ binding site [ion binding]; other site 667014000968 G-X-G motif; other site 667014000969 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 667014000970 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 667014000971 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 667014000972 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000973 active site 667014000974 phosphorylation site [posttranslational modification] 667014000975 intermolecular recognition site; other site 667014000976 dimerization interface [polypeptide binding]; other site 667014000977 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 667014000978 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 667014000979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014000980 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 667014000981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000982 active site 667014000983 phosphorylation site [posttranslational modification] 667014000984 intermolecular recognition site; other site 667014000985 dimerization interface [polypeptide binding]; other site 667014000986 CheB methylesterase; Region: CheB_methylest; pfam01339 667014000987 Response regulator receiver domain; Region: Response_reg; pfam00072 667014000988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014000989 active site 667014000990 phosphorylation site [posttranslational modification] 667014000991 intermolecular recognition site; other site 667014000992 dimerization interface [polypeptide binding]; other site 667014000993 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 667014000994 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 667014000995 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014000996 DRTGG domain; Region: DRTGG; cl12147 667014000997 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 667014000998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014000999 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 667014001000 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014001001 FeoA domain; Region: FeoA; cl00838 667014001002 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 667014001003 metal binding site 2 [ion binding]; metal-binding site 667014001004 putative DNA binding helix; other site 667014001005 metal binding site 1 [ion binding]; metal-binding site 667014001006 dimer interface [polypeptide binding]; other site 667014001007 structural Zn2+ binding site [ion binding]; other site 667014001008 Transposase domain (DUF772); Region: DUF772; cl12084 667014001009 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 667014001010 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 667014001011 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 667014001012 active site 667014001013 dimer interface [polypeptide binding]; other site 667014001014 effector binding site; other site 667014001015 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a...; Region: Hint; cd00081 667014001016 thioester formation/cholesterol transfer; other site 667014001017 protein-splicing catalytic site; other site 667014001018 DNA endonuclease related to intein-encoded endonucleases [DNA replication, recombination, and repair]; Region: COG3780 667014001019 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 667014001020 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 667014001021 TSCPD domain; Region: TSCPD; cl14834 667014001022 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 667014001023 3-dehydroquinate dehydratase, type I; Region: aroD; TIGR01093 667014001024 active site 667014001025 catalytic residue [active] 667014001026 dimer interface [polypeptide binding]; other site 667014001027 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates 5-aminoimidazole-4-carboxamide-; Region: IMPCH; cd01421 667014001028 purine monophosphate binding site [chemical binding]; other site 667014001029 dimer interface [polypeptide binding]; other site 667014001030 putative catalytic residues [active] 667014001031 putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054 667014001032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014001033 FeS/SAM binding site; other site 667014001034 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 667014001035 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014001036 active site 667014001037 phosphorylation site [posttranslational modification] 667014001038 intermolecular recognition site; other site 667014001039 dimerization interface [polypeptide binding]; other site 667014001040 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 667014001041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014001042 Walker A motif; other site 667014001043 ATP binding site [chemical binding]; other site 667014001044 Walker B motif; other site 667014001045 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 667014001046 primosome assembly protein PriA; Validated; Region: PRK05580 667014001047 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014001048 putative deoxyribonuclease YjjV; Provisional; Region: PRK11449 667014001049 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 667014001050 active site 667014001051 Maf-like protein; Region: Maf; pfam02545 667014001052 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 667014001053 active site 667014001054 dimer interface [polypeptide binding]; other site 667014001055 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 667014001056 Gram-negative bacterial tonB protein; Region: TonB; cl10048 667014001057 tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800 667014001058 TolB amino-terminal domain; Region: TolB_N; pfam04052 667014001059 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 667014001060 structural tetrad; other site 667014001061 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 667014001062 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 667014001063 active site 667014001064 Electron transfer flavoprotein, beta subunit [Energy production and conversion]; Region: FixA; COG2086 667014001065 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 667014001066 Ligand binding site [chemical binding]; other site 667014001067 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 667014001068 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 667014001069 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 667014001070 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 667014001071 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin...; Region: NPD_like; cd04730 667014001072 FMN binding site [chemical binding]; other site 667014001073 substrate binding site [chemical binding]; other site 667014001074 putative catalytic residue [active] 667014001075 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 667014001076 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 667014001077 NAD(P) binding site [chemical binding]; other site 667014001078 homotetramer interface [polypeptide binding]; other site 667014001079 homodimer interface [polypeptide binding]; other site 667014001080 active site 667014001081 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 667014001082 YcfA-like protein; Region: YcfA; cl00752 667014001083 Phosphopantetheine attachment site; Region: PP-binding; cl09936 667014001084 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 667014001085 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 667014001086 dimer interface [polypeptide binding]; other site 667014001087 active site 667014001088 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 667014001089 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 667014001090 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of...; Region: SHMT; cd00378 667014001091 dimer interface [polypeptide binding]; other site 667014001092 glycine-pyridoxal phosphate binding site [chemical binding]; other site 667014001093 active site 667014001094 folate binding site [chemical binding]; other site 667014001095 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 667014001096 catalytic motif [active] 667014001097 Zn binding site [ion binding]; other site 667014001098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 667014001099 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 667014001100 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 667014001101 Walker A/P-loop; other site 667014001102 ATP binding site [chemical binding]; other site 667014001103 Q-loop/lid; other site 667014001104 ABC transporter signature motif; other site 667014001105 Walker B; other site 667014001106 D-loop; other site 667014001107 H-loop/switch region; other site 667014001108 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 667014001109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014001110 dimer interface [polypeptide binding]; other site 667014001111 conserved gate region; other site 667014001112 putative PBP binding loops; other site 667014001113 ABC-ATPase subunit interface; other site 667014001114 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 667014001115 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 667014001116 substrate binding pocket [chemical binding]; other site 667014001117 membrane-bound complex binding site; other site 667014001118 hinge residues; other site 667014001119 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 667014001120 aspartate racemase; Region: asp_race; TIGR00035 667014001121 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014001122 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 667014001123 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 667014001124 active site clefts [active] 667014001125 zinc binding site [ion binding]; other site 667014001126 dimer interface [polypeptide binding]; other site 667014001127 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014001128 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014001129 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014001130 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 667014001131 NHL repeat; Region: NHL; pfam01436 667014001132 NHL repeat; Region: NHL; pfam01436 667014001133 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 667014001134 decaheme c-type cytochrome, OmcA/MtrC family; Region: decahem_SO1788; TIGR03507 667014001135 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 667014001136 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014001137 dimer interface [polypeptide binding]; other site 667014001138 phosphorylation site [posttranslational modification] 667014001139 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014001140 ATP binding site [chemical binding]; other site 667014001141 Mg2+ binding site [ion binding]; other site 667014001142 G-X-G motif; other site 667014001143 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 667014001144 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014001145 active site 667014001146 phosphorylation site [posttranslational modification] 667014001147 intermolecular recognition site; other site 667014001148 dimerization interface [polypeptide binding]; other site 667014001149 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 667014001150 DNA binding site [nucleotide binding] 667014001151 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 667014001152 Lumazine binding domain; Region: Lum_binding; pfam00677 667014001153 Lumazine binding domain; Region: Lum_binding; pfam00677 667014001154 Putative transcriptional regulators (Ypuh-like); Region: DUF387; cl00612 667014001155 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 667014001156 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants...; Region: Thr-synth_2; cd01560 667014001157 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014001158 catalytic residue [active] 667014001159 Dissimilatory sulfite reductase D (DsrD); Region: DsrD; pfam08679 667014001160 sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066 667014001161 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 667014001162 sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064 667014001163 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014001164 Roadblock/LC7 domain; Region: Robl_LC7; cl00886 667014001165 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cd00882 667014001166 G1 box; other site 667014001167 GTP/Mg2+ binding site [chemical binding]; other site 667014001168 G2 box; other site 667014001169 Switch I region; other site 667014001170 G3 box; other site 667014001171 Switch II region; other site 667014001172 G4 box; other site 667014001173 G5 box; other site 667014001174 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014001175 binding surface 667014001176 TPR motif; other site 667014001177 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 667014001178 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 667014001179 Walker A motif; other site 667014001180 ATP binding site [chemical binding]; other site 667014001181 Walker B motif; other site 667014001182 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 667014001183 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 667014001184 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 667014001185 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014001186 phosphorylation site [posttranslational modification] 667014001187 dimer interface [polypeptide binding]; other site 667014001188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014001189 ATP binding site [chemical binding]; other site 667014001190 Mg2+ binding site [ion binding]; other site 667014001191 G-X-G motif; other site 667014001192 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014001193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014001194 active site 667014001195 phosphorylation site [posttranslational modification] 667014001196 intermolecular recognition site; other site 667014001197 dimerization interface [polypeptide binding]; other site 667014001198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014001199 Walker A motif; other site 667014001200 ATP binding site [chemical binding]; other site 667014001201 Walker B motif; other site 667014001202 arginine finger; other site 667014001203 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014001204 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 667014001205 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014001206 aminomethyltransferase; Region: PLN02319 667014001207 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014001208 TPR motif; other site 667014001209 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 667014001210 binding surface 667014001211 selenocysteine synthase; Provisional; Region: PRK04311 667014001212 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 667014001213 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 667014001214 catalytic residue [active] 667014001215 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 667014001216 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cl01054 667014001217 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014001218 Cytochrome c552; Region: Cytochrom_C552; pfam02335 667014001219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 667014001220 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014001221 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014001222 Flagellin N-methylase; Region: FliB; cl00497 667014001223 Protein of unknown function (DUF3135); Region: DUF3135; pfam11333 667014001224 cell division protein FtsZ; Validated; Region: PRK09330 667014001225 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum...; Region: FtsZ_type1; cd02201 667014001226 nucleotide binding site [chemical binding]; other site 667014001227 SulA interaction site; other site 667014001228 cell division protein FtsA; Region: ftsA; TIGR01174 667014001229 Cell division protein FtsA; Region: FtsA; cl11496 667014001230 Cell division protein FtsA; Region: FtsA; cl11496 667014001231 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 667014001232 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 667014001233 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 667014001234 FAD binding domain; Region: FAD_binding_4; pfam01565 667014001235 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 667014001236 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 667014001237 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 667014001238 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 667014001239 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 667014001240 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 667014001241 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl...; Region: GT1_MurG; cd03785 667014001242 active site 667014001243 homodimer interface [polypeptide binding]; other site 667014001244 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106 667014001245 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 667014001246 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 667014001247 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 667014001248 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of undecaprenyl-pyrophosphoryl-N-...; Region: GT_MraY; cd06852 667014001249 Mg++ binding site [ion binding]; other site 667014001250 putative catalytic motif [active] 667014001251 putative substrate binding site [chemical binding]; other site 667014001252 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 667014001253 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 667014001254 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 667014001255 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 667014001256 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 667014001257 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 667014001258 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 667014001259 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 667014001260 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 667014001261 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 667014001262 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 667014001263 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 667014001264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014001265 cell division protein MraZ; Reviewed; Region: PRK00326 667014001266 MraZ protein; Region: MraZ; pfam02381 667014001267 MraZ protein; Region: MraZ; pfam02381 667014001268 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 667014001269 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 667014001270 UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589 667014001271 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 667014001272 NAD(P) binding site [chemical binding]; other site 667014001273 homodimer interface [polypeptide binding]; other site 667014001274 substrate binding site [chemical binding]; other site 667014001275 active site 667014001276 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 667014001277 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 667014001278 inhibitor-cofactor binding pocket; inhibition site 667014001279 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014001280 catalytic residue [active] 667014001281 SpsF is a glycosyltrnasferase implicated in the synthesis of the spore coat; Region: GT2_SpsF; cd02518 667014001282 ligand binding site [chemical binding]; other site 667014001283 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 667014001284 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 667014001285 pseudaminic acid synthase; Region: PseI; TIGR03586 667014001286 NeuB family; Region: NeuB; cl00496 667014001287 Thiamine pyrophosphokinase; Region: TPK; cl09135 667014001288 Alpha-2,3-sialyltransferase (CST-I); Region: CST-I; pfam06002 667014001289 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 667014001290 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 667014001291 Protein of unknown function (DUF342); Region: DUF342; pfam03961 667014001292 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 667014001293 Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]; Region: DapD; COG2171 667014001294 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 667014001295 putative trimer interface [polypeptide binding]; other site 667014001296 putative CoA binding site [chemical binding]; other site 667014001297 flagellin; Provisional; Region: PRK12802 667014001298 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 667014001299 Flagellar protein FliS; Region: FliS; cl00654 667014001300 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 667014001301 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 667014001302 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 667014001303 FliW protein; Region: FliW; cl00740 667014001304 Global regulator protein family; Region: CsrA; cl00670 667014001305 flagellar hook-associated protein 3; Region: flagell_flgL; TIGR02550 667014001306 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 667014001307 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 667014001308 flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492 667014001309 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 667014001310 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 667014001311 FlgN protein; Region: FlgN; cl09176 667014001312 Rod binding protein; Region: Rod-binding; cl01626 667014001313 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 667014001314 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 667014001315 Flagellar L-ring protein; Region: FlgH; cl00905 667014001316 SAF domain; Region: SAF; cl00555 667014001317 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 667014001318 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 667014001319 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 667014001320 fagellar hook-basal body proteins; Region: FlgEFG_subfam; TIGR03506 667014001321 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 667014001322 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 667014001323 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 667014001324 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 667014001325 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 667014001326 switch II; other site 667014001327 This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110 667014001328 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 667014001329 P loop nucleotide binding; other site 667014001330 switch II; other site 667014001331 This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851 667014001332 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 667014001333 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014001334 AIR carboxylase; Region: AIRC; cl00310 667014001335 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 667014001336 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using...; Region: AAK_NAGK-C; cd04250 667014001337 feedback inhibition sensing region; other site 667014001338 homohexameric interface [polypeptide binding]; other site 667014001339 nucleotide binding site [chemical binding]; other site 667014001340 N-acetyl-L-glutamate binding site [chemical binding]; other site 667014001341 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014001342 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 667014001343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014001344 Walker A/P-loop; other site 667014001345 ATP binding site [chemical binding]; other site 667014001346 ABC transporter signature motif; other site 667014001347 Walker B; other site 667014001348 D-loop; other site 667014001349 H-loop/switch region; other site 667014001350 Uncharacterised protein family (UPF0014); Region: UPF0014; cl00424 667014001351 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 667014001352 active site 667014001353 ATP binding site [chemical binding]; other site 667014001354 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 667014001355 active site 667014001356 substrate binding site [chemical binding]; other site 667014001357 ATP binding site [chemical binding]; other site 667014001358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 667014001359 active site 667014001360 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 667014001361 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 667014001362 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 667014001363 transketolase; Reviewed; Region: PRK05899 667014001364 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 667014001365 TPP-binding site [chemical binding]; other site 667014001366 dimer interface [polypeptide binding]; other site 667014001367 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 667014001368 PYR/PP interface [polypeptide binding]; other site 667014001369 dimer interface [polypeptide binding]; other site 667014001370 TPP binding site [chemical binding]; other site 667014001371 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 667014001372 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 667014001373 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014001374 putative active site [active] 667014001375 heme pocket [chemical binding]; other site 667014001376 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014001377 dimer interface [polypeptide binding]; other site 667014001378 phosphorylation site [posttranslational modification] 667014001379 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014001380 ATP binding site [chemical binding]; other site 667014001381 Mg2+ binding site [ion binding]; other site 667014001382 G-X-G motif; other site 667014001383 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014001384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014001385 active site 667014001386 phosphorylation site [posttranslational modification] 667014001387 intermolecular recognition site; other site 667014001388 dimerization interface [polypeptide binding]; other site 667014001389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014001390 Walker A motif; other site 667014001391 ATP binding site [chemical binding]; other site 667014001392 Walker B motif; other site 667014001393 arginine finger; other site 667014001394 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014001395 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 667014001396 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014001397 Walker A/P-loop; other site 667014001398 ATP binding site [chemical binding]; other site 667014001399 Q-loop/lid; other site 667014001400 ABC transporter signature motif; other site 667014001401 Walker B; other site 667014001402 D-loop; other site 667014001403 H-loop/switch region; other site 667014001404 TOBE domain; Region: TOBE_2; cl01440 667014001405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014001406 dimer interface [polypeptide binding]; other site 667014001407 conserved gate region; other site 667014001408 putative PBP binding loops; other site 667014001409 ABC-ATPase subunit interface; other site 667014001410 putative molybdenum utilization protein ModD; Region: modD; TIGR01334 667014001411 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 667014001412 dimerization interface [polypeptide binding]; other site 667014001413 active site 667014001414 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014001415 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 667014001416 Aspartase; Region: Aspartase; cd01357 667014001417 active sites [active] 667014001418 tetramer interface [polypeptide binding]; other site 667014001419 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 667014001420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014001421 FeS/SAM binding site; other site 667014001422 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 667014001423 putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959 667014001424 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 667014001425 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 667014001426 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 667014001427 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 667014001428 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 667014001429 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 667014001430 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 667014001431 4Fe-4S binding domain; Region: Fer4; cl02805 667014001432 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 667014001433 hydrogenase maturation GTPase HydF; Region: GTP_HydF; TIGR03918 667014001434 Era (E. coli Ras-like protein)-like. This family includes several distinct subfamilies (TrmE/ThdF, FeoB, YihA (EngG), Era, and EngA/YfgK) that generally show sequence conservation in the region between the Walker A and B motifs (G1 and G3 box motifs)...; Region: Era_like; cd00880 667014001435 G1 box; other site 667014001436 GTP/Mg2+ binding site [chemical binding]; other site 667014001437 Switch I region; other site 667014001438 G2 box; other site 667014001439 Switch II region; other site 667014001440 G3 box; other site 667014001441 G4 box; other site 667014001442 G5 box; other site 667014001443 biotin synthase; Provisional; Region: PRK07094 667014001444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014001445 FeS/SAM binding site; other site 667014001446 Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149 667014001447 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 667014001448 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 667014001449 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 667014001450 intersubunit interface [polypeptide binding]; other site 667014001451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 667014001452 dimer interface [polypeptide binding]; other site 667014001453 putative PBP binding regions; other site 667014001454 ABC-ATPase subunit interface; other site 667014001455 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 667014001456 ABC transporters, involved in the uptake of siderophores, heme, and vitamin B12, are widely conserved in bacteria and archaea. Only very few species lack representatives of the siderophore family transporters. The E. coli BtuCD protein is an ABC...; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 667014001457 Walker A/P-loop; other site 667014001458 ATP binding site [chemical binding]; other site 667014001459 Q-loop/lid; other site 667014001460 ABC transporter signature motif; other site 667014001461 Walker B; other site 667014001462 D-loop; other site 667014001463 H-loop/switch region; other site 667014001464 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 667014001465 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 667014001466 peptide binding site [polypeptide binding]; other site 667014001467 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 667014001468 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 667014001469 Ligand Binding Site [chemical binding]; other site 667014001470 TIGR00269 family protein; Region: TIGR00269 667014001471 Ribonuclease BN-like family; Region: Ribonuclease_BN; cl07918 667014001472 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014001473 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 667014001474 Secretin and TonB N terminus short domain; Region: STN; cl06624 667014001475 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 667014001476 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 667014001477 Pilus assembly protein, PilP; Region: PilP; cl01235 667014001478 Pilus assembly protein, PilO; Region: PilO; cl01234 667014001479 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 667014001480 Competence protein A; Region: Competence_A; pfam11104 667014001481 GTP-binding protein LepA; Provisional; Region: PRK05433 667014001482 LepA subfamily. LepA belongs to the GTPase family of and exhibits significant homology to the translation factors EF-G and EF-Tu, indicating its possible involvement in translation and association with the ribosome. LepA is ubiquitous in bacteria and...; Region: LepA; cd01890 667014001483 G1 box; other site 667014001484 putative GEF interaction site [polypeptide binding]; other site 667014001485 GTP/Mg2+ binding site [chemical binding]; other site 667014001486 Switch I region; other site 667014001487 G2 box; other site 667014001488 G3 box; other site 667014001489 Switch II region; other site 667014001490 G4 box; other site 667014001491 G5 box; other site 667014001492 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-...; Region: lepA_II; cd03699 667014001493 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 667014001494 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 667014001495 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 667014001496 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 667014001497 Catalytic site [active] 667014001498 hypothetical protein; Provisional; Region: PRK14852 667014001499 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 667014001500 metal binding site [ion binding]; metal-binding site 667014001501 active site 667014001502 I-site; other site 667014001503 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 667014001504 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014001505 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 667014001506 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl11426 667014001507 Glu-tRNAGln amidotransferase C subunit; Region: Glu-tRNAGln; cl00495 667014001508 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 667014001509 dimer interface [polypeptide binding]; other site 667014001510 phosphomethylpyrimidine kinase; Provisional; Region: PRK08573 667014001511 substrate binding site [chemical binding]; other site 667014001512 ATP binding site [chemical binding]; other site 667014001513 Archaeal phosphomethylpyrimidine kinase; Region: MethylPyrKinase; cl00871 667014001514 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the...; Region: mcbC-like_oxidoreductase; cd02142 667014001515 putative FMN binding site [chemical binding]; other site 667014001516 NADPH bind site [chemical binding]; other site 667014001517 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 667014001518 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 667014001519 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 667014001520 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 667014001521 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 667014001522 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 667014001523 active site 667014001524 metal binding site [ion binding]; metal-binding site 667014001525 homotetramer interface [polypeptide binding]; other site 667014001526 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 667014001527 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 667014001528 putative dimer interface [polypeptide binding]; other site 667014001529 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 667014001530 putative dimer interface [polypeptide binding]; other site 667014001531 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 667014001532 YcaO-like family; Region: YcaO; cl09146 667014001533 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014001534 TPR motif; other site 667014001535 binding surface 667014001536 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 667014001537 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014001538 binding surface 667014001539 TPR motif; other site 667014001540 NIL domain; Region: NIL; cl09633 667014001541 4Fe-4S binding domain; Region: Fer4; cl02805 667014001542 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 667014001543 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 667014001544 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs...; Region: tRNA_Me_trans; cd01998 667014001545 Ligand Binding Site [chemical binding]; other site 667014001546 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 667014001547 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 667014001548 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 667014001549 2-isopropylmalate synthase; Validated; Region: PRK00915 667014001550 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 667014001551 active site 667014001552 catalytic residues [active] 667014001553 metal binding site [ion binding]; metal-binding site 667014001554 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 667014001555 Response regulator receiver domain; Region: Response_reg; pfam00072 667014001556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014001557 active site 667014001558 phosphorylation site [posttranslational modification] 667014001559 intermolecular recognition site; other site 667014001560 dimerization interface [polypeptide binding]; other site 667014001561 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 667014001562 DNA-K related protein; Region: DUF3731; pfam12531 667014001563 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 667014001564 IHF dimer interface [polypeptide binding]; other site 667014001565 IHF - DNA interface [nucleotide binding]; other site 667014001566 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and...; Region: PBPb; cd00134 667014001567 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 667014001568 substrate binding pocket [chemical binding]; other site 667014001569 membrane-bound complex binding site; other site 667014001570 hinge residues; other site 667014001571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014001572 dimer interface [polypeptide binding]; other site 667014001573 conserved gate region; other site 667014001574 putative PBP binding loops; other site 667014001575 ABC-ATPase subunit interface; other site 667014001576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014001577 dimer interface [polypeptide binding]; other site 667014001578 conserved gate region; other site 667014001579 putative PBP binding loops; other site 667014001580 ABC-ATPase subunit interface; other site 667014001581 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 667014001582 HisP and GlnQ are the ATP-binding components of the bacterial periplasmic histidine and glutamine permeases, repectively. Histidine permease is a multisubunit complex containing the HisQ and HisM integral membrane subunits and two copies of HisP; Region: ABC_HisP_GlnQ_permeases; cd03262 667014001583 Walker A/P-loop; other site 667014001584 ATP binding site [chemical binding]; other site 667014001585 Q-loop/lid; other site 667014001586 ABC transporter signature motif; other site 667014001587 Walker B; other site 667014001588 D-loop; other site 667014001589 H-loop/switch region; other site 667014001590 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 667014001591 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 667014001592 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; cl00668 667014001593 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 667014001594 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 667014001595 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 667014001596 DctM-like transporters; Region: DctM; pfam06808 667014001597 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014001598 Mth938 domain. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a dimer, although it is monomeric in solution, with one disulfide bond in each monomer. The function of the...; Region: Mth938; cd05126 667014001599 peptide chain release factor 1; Validated; Region: prfA; PRK00591 667014001600 RF-1 domain; Region: RF-1; cl02875 667014001601 RF-1 domain; Region: RF-1; cl02875 667014001602 Ribosomal protein L31; Region: Ribosomal_L31; cl00377 667014001603 transcription termination factor Rho; Provisional; Region: rho; PRK09376 667014001604 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 667014001605 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent...; Region: Rho_CSD; cd04459 667014001606 RNA binding site [nucleotide binding]; other site 667014001607 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of...; Region: rho_factor; cd01128 667014001608 multimer interface [polypeptide binding]; other site 667014001609 Walker A motif; other site 667014001610 ATP binding site [chemical binding]; other site 667014001611 Walker B motif; other site 667014001612 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 667014001613 heterodimer interface [polypeptide binding]; other site 667014001614 active site 667014001615 FMN binding site [chemical binding]; other site 667014001616 homodimer interface [polypeptide binding]; other site 667014001617 substrate binding site [chemical binding]; other site 667014001618 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 667014001619 active site 667014001620 intersubunit interactions; other site 667014001621 catalytic residue [active] 667014001622 argininosuccinate synthase; Provisional; Region: PLN00200 667014001623 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 667014001624 ANP binding site [chemical binding]; other site 667014001625 Substrate Binding Site II [chemical binding]; other site 667014001626 Substrate Binding Site I [chemical binding]; other site 667014001627 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 667014001628 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 667014001629 substrate binding pocket [chemical binding]; other site 667014001630 chain length determination region; other site 667014001631 substrate-Mg2+ binding site; other site 667014001632 catalytic residues [active] 667014001633 aspartate-rich region 1; other site 667014001634 active site lid residues [active] 667014001635 aspartate-rich region 2; other site 667014001636 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 667014001637 Type I periplasmic binding component of ABC (ATPase Binding Cassette)-type transport systems that are predicted to be involved in uptake of amino acids; Region: PBP1_ABC-type_HAAT_like; cd06333 667014001638 putative ligand binding site [chemical binding]; other site 667014001639 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 667014001640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014001641 active site 667014001642 motif I; other site 667014001643 motif II; other site 667014001644 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 667014001645 dimerization interface [polypeptide binding]; other site 667014001646 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014001647 dimer interface [polypeptide binding]; other site 667014001648 phosphorylation site [posttranslational modification] 667014001649 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014001650 ATP binding site [chemical binding]; other site 667014001651 Mg2+ binding site [ion binding]; other site 667014001652 G-X-G motif; other site 667014001653 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 667014001654 peptidase T-like protein; Region: PepT-like; TIGR01883 667014001655 metal binding site [ion binding]; metal-binding site 667014001656 putative dimer interface [polypeptide binding]; other site 667014001657 Acylphosphatase; Region: Acylphosphatase; cl00551 667014001658 Protein of unknown function (DUF342); Region: DUF342; pfam03961 667014001659 Uncharacterized ACR, COG1993; Region: DUF190; cl00872 667014001660 CrcB-like protein; Region: CRCB; cl09114 667014001661 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 667014001662 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 667014001663 active site 667014001664 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 667014001665 dimer interface [polypeptide binding]; other site 667014001666 catalytic triad [active] 667014001667 Bordetella pertussis Bvg accessory factor family; Region: Bvg_acc_factor; cl09130 667014001668 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 667014001669 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014001670 Peptidase family M48; Region: Peptidase_M48; cl12018 667014001671 photosystem I assembly protein Ycf3; Provisional; Region: PRK02603 667014001672 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 667014001673 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 667014001674 N-terminal plug; other site 667014001675 ligand-binding site [chemical binding]; other site 667014001676 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK05989 667014001677 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 667014001678 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 667014001679 catalytic motif [active] 667014001680 Zn binding site [ion binding]; other site 667014001681 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5,10-...; Region: DHFR; cl00161 667014001682 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 667014001683 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014001684 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 667014001685 synthetase active site [active] 667014001686 NTP binding site [chemical binding]; other site 667014001687 metal binding site [ion binding]; metal-binding site 667014001688 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named...; Region: TGS_RelA_SpoT; cd01668 667014001689 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 667014001690 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 667014001691 replicative DNA helicase; Region: DnaB; TIGR00665 667014001692 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 667014001693 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 667014001694 Walker A motif; other site 667014001695 ATP binding site [chemical binding]; other site 667014001696 Walker B motif; other site 667014001697 DNA binding loops [nucleotide binding] 667014001698 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid...; Region: MECDP_synthase; cd00554 667014001699 homotrimer interaction site [polypeptide binding]; other site 667014001700 zinc binding site [ion binding]; other site 667014001701 CDP-binding sites; other site 667014001702 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 667014001703 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 667014001704 GIY-YIG motif/motif A; other site 667014001705 active site 667014001706 catalytic site [active] 667014001707 putative DNA binding site [nucleotide binding]; other site 667014001708 metal binding site [ion binding]; metal-binding site 667014001709 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 667014001710 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 667014001711 DNA binding site [nucleotide binding] 667014001712 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014001713 Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191 667014001714 FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663 667014001715 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 667014001716 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 667014001717 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014001718 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Validated; Region: PRK09369 667014001719 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 667014001720 hinge; other site 667014001721 active site 667014001722 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 667014001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014001724 S-adenosylmethionine binding site [chemical binding]; other site 667014001725 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 667014001726 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 667014001727 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014001728 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 667014001729 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 667014001730 dimer interface [polypeptide binding]; other site 667014001731 anticodon binding site; other site 667014001732 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of the...; Region: AspRS_core; cd00777 667014001733 homodimer interface [polypeptide binding]; other site 667014001734 motif 1; other site 667014001735 active site 667014001736 motif 2; other site 667014001737 GAD domain; Region: GAD; pfam02938 667014001738 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 667014001739 active site 667014001740 motif 3; other site 667014001741 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 667014001742 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is...; Region: GT1_TPS; cd03788 667014001743 active site 667014001744 homotetramer interface [polypeptide binding]; other site 667014001745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 667014001746 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014001747 Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose...; Region: GT1_Trehalose_phosphorylase; cd03792 667014001748 LysE type translocator; Region: LysE; cl00565 667014001749 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 667014001750 Pyridoxal phosphate biosynthetic protein PdxA; Region: PdxA; cl00873 667014001751 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 667014001752 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014001753 FeS/SAM binding site; other site 667014001754 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 667014001755 NeuB family; Region: NeuB; cl00496 667014001756 Mechanosensitive ion channel; Region: MS_channel; pfam00924 667014001757 recombinase A; Provisional; Region: recA; PRK09354 667014001758 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 667014001759 hexamer interface [polypeptide binding]; other site 667014001760 Walker A motif; other site 667014001761 ATP binding site [chemical binding]; other site 667014001762 Walker B motif; other site 667014001763 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 667014001764 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 667014001765 putative ribose interaction site [chemical binding]; other site 667014001766 putative ADP binding site [chemical binding]; other site 667014001767 Membrane transport protein; Region: Mem_trans; cl09117 667014001768 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 667014001769 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 667014001770 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 667014001771 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 667014001772 Surface antigen variable number repeat; Region: Surf_Ag_VNR; cl10520 667014001773 Surface antigen; Region: Bac_surface_Ag; cl03097 667014001774 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 667014001775 This family is comprised of MJ0796 ATP-binding cassette, macrolide-specific ABC-type efflux carrier (MacAB), and proteins involved in cell division (FtsE), and release of liporoteins from the cytoplasmic membrane (LolCDE). They are clustered together...; Region: ABC_MJ0796_Lo1CDE_FtsE; cd03255 667014001776 Walker A/P-loop; other site 667014001777 ATP binding site [chemical binding]; other site 667014001778 Q-loop/lid; other site 667014001779 ABC transporter signature motif; other site 667014001780 Walker B; other site 667014001781 D-loop; other site 667014001782 H-loop/switch region; other site 667014001783 LolC/E family; Region: lolCE; TIGR02212 667014001784 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 667014001785 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 667014001786 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-...; Region: LysRS_N; cd04322 667014001787 dimer interface [polypeptide binding]; other site 667014001788 putative anticodon binding site; other site 667014001789 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 667014001790 motif 1; other site 667014001791 active site 667014001792 motif 2; other site 667014001793 motif 3; other site 667014001794 UvrD/REP helicase; Region: UvrD-helicase; cl14126 667014001795 ATP-dependent DNA helicase Rep; Region: rep; TIGR01074 667014001796 UvrD/REP helicase; Region: UvrD-helicase; cl14126 667014001797 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 667014001798 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014001799 Protein of unknown function, DUF488; Region: DUF488; cl01246 667014001800 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 667014001801 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 667014001802 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 667014001803 probable DNA repair protein; Region: TIGR03623 667014001804 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 667014001805 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 667014001806 UvrD/REP helicase; Region: UvrD-helicase; cl14126 667014001807 UvrD/REP helicase; Region: UvrD-helicase; cl14126 667014001808 DNA helicase II; Region: uvrD; TIGR01075 667014001809 conserved hypothetical protein; Region: TIGR02231 667014001810 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 667014001811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014001812 FeS/SAM binding site; other site 667014001813 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 667014001814 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020 667014001815 dimer interface [polypeptide binding]; other site 667014001816 active site residues [active] 667014001817 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 667014001818 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 667014001819 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014001820 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 667014001821 putative dimerization interface [polypeptide binding]; other site 667014001822 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 667014001823 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a four-...; Region: RecG_wedge_OBF; cd04488 667014001824 ssDNA binding site; other site 667014001825 generic binding surface II; other site 667014001826 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 667014001827 ATP binding site [chemical binding]; other site 667014001828 putative Mg++ binding site [ion binding]; other site 667014001829 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 667014001830 nucleotide binding region [chemical binding]; other site 667014001831 ATP-binding site [chemical binding]; other site 667014001832 homoserine dehydrogenase; Provisional; Region: PRK06349 667014001833 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014001834 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 667014001835 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 667014001836 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 667014001837 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 667014001838 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this two-...; Region: SirA_YedF_YeeD; cd00291 667014001839 CPxP motif; other site 667014001840 putative inner membrane protein; Provisional; Region: PRK11099 667014001841 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 667014001842 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 667014001843 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 667014001844 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 667014001845 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 667014001846 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 667014001847 Domain of unknown function (DUF364); Region: DUF364; cl00885 667014001848 Domain of unknown function DUF59; Region: DUF59; cl00941 667014001849 antiporter inner membrane protein; Provisional; Region: PRK11670 667014001850 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 667014001851 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 667014001852 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 667014001853 TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine at the wobble position (U34) of tRNAs that read codons ending with A or G in the mixed codon family boxes. TrmE contains a GTPase...; Region: trmE; cd04164 667014001854 G1 box; other site 667014001855 GTP/Mg2+ binding site [chemical binding]; other site 667014001856 Switch I region; other site 667014001857 G2 box; other site 667014001858 Switch II region; other site 667014001859 G3 box; other site 667014001860 G4 box; other site 667014001861 G5 box; other site 667014001862 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 667014001863 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 667014001864 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 667014001865 G-X-X-G motif; other site 667014001866 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 667014001867 RxxxH motif; other site 667014001868 membrane protein insertase; Provisional; Region: PRK01318 667014001869 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 667014001870 Domain of unknown function DUF37; Region: DUF37; cl00506 667014001871 Ribonuclease P; Region: Ribonuclease_P; cl00457 667014001872 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 667014001873 YfdX protein; Region: YfdX; pfam10938 667014001874 putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498 667014001875 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 667014001876 dimer interface [polypeptide binding]; other site 667014001877 putative functional site; other site 667014001878 putative MPT binding site; other site 667014001879 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014001880 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 667014001881 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 667014001882 P-loop; other site 667014001883 Magnesium ion binding site [ion binding]; other site 667014001884 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 667014001885 Magnesium ion binding site [ion binding]; other site 667014001886 PemK-like protein; Region: PemK; cl00995 667014001887 Protein of unknown function (DUF2281); Region: DUF2281; cl02355 667014001888 Uncharacterised protein family UPF0102; Region: UPF0102; cl00516 667014001889 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 667014001890 RNA/DNA hybrid binding site [nucleotide binding]; other site 667014001891 active site 667014001892 Ribosomal protein L19; Region: Ribosomal_L19; cl00406 667014001893 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 667014001894 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 667014001895 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 667014001896 magnesium/nickel/cobalt transporter CorA; Provisional; Region: PRK11085; cl00459 667014001897 Bacitracin resistance protein BacA; Region: BacA; cl00858 667014001898 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 667014001899 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 667014001900 protein binding site [polypeptide binding]; other site 667014001901 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014001902 S-adenosylmethionine binding site [chemical binding]; other site 667014001903 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 667014001904 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 667014001905 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 667014001906 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 667014001907 spermidine synthase; Provisional; Region: PRK00811 667014001908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014001909 S-adenosylmethionine binding site [chemical binding]; other site 667014001910 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 667014001911 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014001912 DctM-like transporters; Region: DctM; pfam06808 667014001913 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 667014001914 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl15260 667014001915 Uncharacterized conserved protein [Function unknown]; Region: COG1641; cl03398 667014001916 Protein of unknown function DUF111; Region: DUF111; pfam01969 667014001917 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 667014001918 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014001919 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; cl10556 667014001920 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 667014001921 heme bL binding site [chemical binding]; other site 667014001922 interchain domain interface [polypeptide binding]; other site 667014001923 intrachain domain interface; other site 667014001924 heme bH binding site [chemical binding]; other site 667014001925 Qo binding site; other site 667014001926 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1)...; Region: Rieske; cd03467 667014001927 iron-sulfur cluster [ion binding]; other site 667014001928 [2Fe-2S] cluster binding site [ion binding]; other site 667014001929 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 667014001930 TRAM domain; Region: TRAM; cl01282 667014001931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014001932 cysteine synthases; Region: cysKM; TIGR01136 667014001933 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine...; Region: CBS_like; cd01561 667014001934 dimer interface [polypeptide binding]; other site 667014001935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014001936 catalytic residue [active] 667014001937 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 667014001938 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 667014001939 active site 667014001940 HIGH motif; other site 667014001941 nucleotide binding site [chemical binding]; other site 667014001942 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 667014001943 KMSKS motif; other site 667014001944 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 667014001945 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014001946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014001947 active site 667014001948 phosphorylation site [posttranslational modification] 667014001949 intermolecular recognition site; other site 667014001950 dimerization interface [polypeptide binding]; other site 667014001951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014001952 Walker A motif; other site 667014001953 ATP binding site [chemical binding]; other site 667014001954 Walker B motif; other site 667014001955 arginine finger; other site 667014001956 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014001957 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 667014001958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014001959 dimer interface [polypeptide binding]; other site 667014001960 phosphorylation site [posttranslational modification] 667014001961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014001962 ATP binding site [chemical binding]; other site 667014001963 Mg2+ binding site [ion binding]; other site 667014001964 G-X-G motif; other site 667014001965 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 667014001966 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014001967 Walker A/P-loop; other site 667014001968 ATP binding site [chemical binding]; other site 667014001969 Q-loop/lid; other site 667014001970 ABC transporter signature motif; other site 667014001971 Walker B; other site 667014001972 D-loop; other site 667014001973 H-loop/switch region; other site 667014001974 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 667014001975 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014001976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 667014001977 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 667014001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014001979 dimer interface [polypeptide binding]; other site 667014001980 conserved gate region; other site 667014001981 putative PBP binding loops; other site 667014001982 ABC-ATPase subunit interface; other site 667014001983 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 667014001984 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 667014001985 active site 667014001986 catalytic site [active] 667014001987 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014001988 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014001989 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 667014001990 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 667014001991 DNA binding site [nucleotide binding] 667014001992 Int/Topo IB signature motif; other site 667014001993 active site 667014001994 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 667014001995 active site 667014001996 HslU subunit interaction site [polypeptide binding]; other site 667014001997 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 667014001998 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014001999 Walker A motif; other site 667014002000 ATP binding site [chemical binding]; other site 667014002001 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014002002 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 667014002003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014002004 FeS/SAM binding site; other site 667014002005 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 667014002006 putative peptidoglycan binding site; other site 667014002007 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 667014002008 Anti-sigma-28 factor, FlgM; Region: FlgM; cl01052 667014002009 N-terminal domain of Chondroitin polymerase functions as a GalNAc transferase; Region: GT2_Chondriotin_Pol_N; cd06420 667014002010 Substrate binding site [chemical binding]; other site 667014002011 metal binding site [ion binding]; metal-binding site 667014002012 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 667014002013 putative metal binding site [ion binding]; other site 667014002014 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 667014002015 O-Antigen ligase; Region: Wzy_C; cl04850 667014002016 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 667014002017 active site 667014002018 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 667014002019 ABC transporter transmembrane region; Region: ABC_membrane; cl00549 667014002020 MsbA is an essential ABC transporter, closely related to eukaryotic MDR proteins. ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex organic...; Region: ABCC_MsbA; cd03251 667014002021 Walker A/P-loop; other site 667014002022 ATP binding site [chemical binding]; other site 667014002023 Q-loop/lid; other site 667014002024 ABC transporter signature motif; other site 667014002025 Walker B; other site 667014002026 D-loop; other site 667014002027 H-loop/switch region; other site 667014002028 peptide chain release factor 2; Validated; Region: prfB; PRK00578 667014002029 RF-1 domain; Region: RF-1; cl02875 667014002030 RF-1 domain; Region: RF-1; cl02875 667014002031 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 667014002032 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 667014002033 putative active site [active] 667014002034 catalytic triad [active] 667014002035 putative dimer interface [polypeptide binding]; other site 667014002036 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 667014002037 Transporter associated domain; Region: CorC_HlyC; cl08393 667014002038 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 667014002039 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 667014002040 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 667014002041 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 667014002042 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG1427 667014002043 Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271 667014002044 polysaccharide deactylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 667014002045 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 667014002046 Domain of unknown function (DUF3473); Region: DUF3473; pfam11959 667014002047 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 667014002048 YcfA-like protein; Region: YcfA; cl00752 667014002049 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 667014002050 FemAB family; Region: FemAB; cl11444 667014002051 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 667014002052 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 667014002053 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 667014002054 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 667014002055 putative ADP-binding pocket [chemical binding]; other site 667014002056 exosortase 1 system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 667014002057 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 667014002058 active site 667014002059 dimer interface [polypeptide binding]; other site 667014002060 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes...; Region: Asn_Synthase_B_C; cd01991 667014002061 Ligand Binding Site [chemical binding]; other site 667014002062 Molecular Tunnel; other site 667014002063 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014002064 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 667014002065 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 667014002066 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-...; Region: AP2Ec; cl12060 667014002067 Metal-binding active site; metal-binding site 667014002068 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 667014002069 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 667014002070 inhibitor-cofactor binding pocket; inhibition site 667014002071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014002072 catalytic residue [active] 667014002073 Undecaprenyl-phosphate galactose phosphotransferase, WbaP; Region: WbaP_sugtrans; TIGR03022 667014002074 Bacterial sugar transferase; Region: Bac_transf; cl00939 667014002075 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 667014002076 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 667014002077 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 667014002078 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 667014002079 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 667014002080 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014002081 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014002082 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 667014002083 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 667014002084 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 667014002085 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 667014002086 putative active site [active] 667014002087 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 667014002088 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 667014002089 putative active site [active] 667014002090 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 667014002091 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 667014002092 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 667014002093 NADP binding site [chemical binding]; other site 667014002094 active site 667014002095 putative substrate binding site [chemical binding]; other site 667014002096 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 667014002097 dTDP-glucose 4,6-dehydratase; Region: dTDP_gluc_dehyt; TIGR01181 667014002098 NAD binding site [chemical binding]; other site 667014002099 substrate binding site [chemical binding]; other site 667014002100 homodimer interface [polypeptide binding]; other site 667014002101 active site 667014002102 Cupin domain; Region: Cupin_2; cl09118 667014002103 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 667014002104 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 667014002105 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 667014002106 substrate binding site [chemical binding]; other site 667014002107 tetramer interface [polypeptide binding]; other site 667014002108 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014002109 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_6; cd04955 667014002110 polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591 667014002111 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 667014002112 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 667014002113 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 667014002114 NeuB family; Region: NeuB; cl00496 667014002115 SAF domain; Region: SAF; cl00555 667014002116 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 667014002117 ligand binding site [chemical binding]; other site 667014002118 tetramer interface [polypeptide binding]; other site 667014002119 pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590 667014002120 Glycosyl transferases group 1; Region: Glycos_transf_1; cl12012 667014002121 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 667014002122 PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855 667014002123 putative active site [active] 667014002124 Archaeal ATPase; Region: Arch_ATPase; pfam01637 667014002125 S23 ribosomal protein; Region: Ribosomal_S23p; cl05287 667014002126 Domain of unknown function DUF28; Region: DUF28; cl00361 667014002127 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD includes...; Region: RuvC_resolvase; cd00529 667014002128 active site 667014002129 putative DNA-binding cleft [nucleotide binding]; other site 667014002130 dimer interface [polypeptide binding]; other site 667014002131 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 667014002132 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 667014002133 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 667014002134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014002135 Walker A motif; other site 667014002136 ATP binding site [chemical binding]; other site 667014002137 Walker B motif; other site 667014002138 arginine finger; other site 667014002139 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 667014002140 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 667014002141 oligomerization interface [polypeptide binding]; other site 667014002142 active site 667014002143 metal binding site [ion binding]; metal-binding site 667014002144 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014002145 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002146 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014002147 4Fe-4S binding domain; Region: Fer4; cl02805 667014002148 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 667014002149 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 667014002150 Predicted methyltransferases [General function prediction only]; Region: COG0313 667014002151 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 667014002152 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 667014002153 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 667014002154 Myo-inositol-1-phosphate synthase; Region: Inos-1-P_synth; cl00554 667014002155 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 667014002156 aspartate aminotransferase; Provisional; Region: PRK07681 667014002157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 667014002158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014002159 homodimer interface [polypeptide binding]; other site 667014002160 catalytic residue [active] 667014002161 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 667014002162 catalytic center binding site [active] 667014002163 ATP binding site [chemical binding]; other site 667014002164 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 667014002165 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 667014002166 N-acetyl-D-glucosamine binding site [chemical binding]; other site 667014002167 catalytic residue [active] 667014002168 Uncharacterized ACR, COG1469; Region: DUF198; cl00642 667014002169 CO dehydrogenase maturation factor [Cell division and chromosome partitioning]; Region: CooC; COG3640 667014002170 The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034 667014002171 P-loop; other site 667014002172 prolyl-tRNA synthetase; Provisional; Region: PRK09194 667014002173 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: ProRS_core_prok; cd00779 667014002174 dimer interface [polypeptide binding]; other site 667014002175 motif 1; other site 667014002176 active site 667014002177 motif 2; other site 667014002178 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and single-...; Region: ProRS-INS; cd04334 667014002179 putative deacylase active site [active] 667014002180 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 667014002181 active site 667014002182 motif 3; other site 667014002183 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-...; Region: ProRS_anticodon_short; cd00861 667014002184 anticodon binding site; other site 667014002185 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 667014002186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 667014002187 RNA binding surface [nucleotide binding]; other site 667014002188 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014002189 S-adenosylmethionine binding site [chemical binding]; other site 667014002190 FOG: CBS domain [General function prediction only]; Region: COG0517 667014002191 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 667014002192 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cl09141 667014002193 Transglycosylase; Region: Transgly; cl07896 667014002194 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 667014002195 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 667014002196 Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818 667014002197 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014002198 Walker A/P-loop; other site 667014002199 ATP binding site [chemical binding]; other site 667014002200 Q-loop/lid; other site 667014002201 ABC transporter signature motif; other site 667014002202 Walker B; other site 667014002203 D-loop; other site 667014002204 H-loop/switch region; other site 667014002205 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group...; Region: OAT; cd02152 667014002206 heterotetramer interface [polypeptide binding]; other site 667014002207 active site pocket [active] 667014002208 cleavage site 667014002209 Survival protein SurE; Region: SurE; cl00448 667014002210 Rrf2 family protein; Region: rrf2_super; TIGR00738 667014002211 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 667014002212 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014002213 FeS/SAM binding site; other site 667014002214 radical SAM additional 4Fe4S-binding domain; Region: rSAM_more_4Fe4S; TIGR04085 667014002215 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 667014002216 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 667014002217 active site 667014002218 HIGH motif; other site 667014002219 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 667014002220 KMSKS motif; other site 667014002221 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 667014002222 Colicin V production protein; Region: Colicin_V; cl00567 667014002223 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 667014002224 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 667014002225 MazG nucleotide pyrophosphohydrolase domain; Region: MazG; cl00345 667014002226 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 667014002227 active site 667014002228 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 667014002229 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine residue is found in...; Region: RNA_Cyclase_Class_II; cd00874 667014002230 putative active site [active] 667014002231 adenylation catalytic residue [active] 667014002232 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 667014002233 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 667014002234 Walker A/P-loop; other site 667014002235 ATP binding site [chemical binding]; other site 667014002236 Q-loop/lid; other site 667014002237 ABC transporter signature motif; other site 667014002238 Walker B; other site 667014002239 D-loop; other site 667014002240 H-loop/switch region; other site 667014002241 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 667014002242 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 667014002243 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014002244 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014002245 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 667014002246 putative active site [active] 667014002247 SpoVT / AbrB like domain; Region: SpoVT_AbrB; cl00877 667014002248 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 667014002249 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 667014002250 Walker A/P-loop; other site 667014002251 ATP binding site [chemical binding]; other site 667014002252 Q-loop/lid; other site 667014002253 ABC transporter signature motif; other site 667014002254 Walker B; other site 667014002255 D-loop; other site 667014002256 H-loop/switch region; other site 667014002257 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 667014002258 Rhomboid family; Region: Rhomboid; cl11446 667014002259 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 667014002260 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 667014002261 active site 667014002262 Conserved TM helix; Region: TM_helix; pfam05552 667014002263 Conserved TM helix; Region: TM_helix; pfam05552 667014002264 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 667014002265 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 667014002266 Glycosyl hydrolases family 38 N-terminal domain; Region: Glyco_hydro_38; pfam01074 667014002267 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 667014002268 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 667014002269 Quinolinate synthetase A protein; Region: NadA; cl00420 667014002270 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl01065 667014002271 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 667014002272 Protein of unknown function (DUF998); Region: DUF998; cl01334 667014002273 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014002274 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 667014002275 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 667014002276 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 667014002277 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 667014002278 FOG: CBS domain [General function prediction only]; Region: COG0517 667014002279 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-...; Region: CBS_pair; cd02205 667014002280 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 667014002281 active site 667014002282 multimer interface [polypeptide binding]; other site 667014002283 thiamine monophosphate kinase; Provisional; Region: PRK05731 667014002284 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 667014002285 ATP binding site [chemical binding]; other site 667014002286 dimerization interface [polypeptide binding]; other site 667014002287 Protein of unknown function (DUF505); Region: DUF505; pfam04458 667014002288 ParB-like nuclease domain; Region: ParBc; cl02129 667014002289 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 667014002290 putative ligand binding pocket/active site [active] 667014002291 putative metal binding site [ion binding]; other site 667014002292 Heterodisulfide reductase, subunit C [Energy production and conversion]; Region: HdrC; COG1150 667014002293 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 667014002294 Cysteine-rich domain; Region: CCG; pfam02754 667014002295 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 667014002296 Organic solvent tolerance protein; Region: OstA_C; pfam04453 667014002297 bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308 667014002298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 667014002299 Coenzyme A binding pocket [chemical binding]; other site 667014002300 Sporulation related domain; Region: SPOR; cl10051 667014002301 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 667014002302 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; cl04104 667014002303 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 667014002304 active site 667014002305 HIGH motif; other site 667014002306 KMSK motif region; other site 667014002307 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 667014002308 tRNA binding surface [nucleotide binding]; other site 667014002309 anticodon binding site; other site 667014002310 Predicted RNA-binding protein; Region: RNA_bind_2; cl00662 667014002311 elongation factor P; Validated; Region: PRK00529 667014002312 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 667014002313 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_1; cd04470 667014002314 RNA binding site [nucleotide binding]; other site 667014002315 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with N-formylmethionyl-...; Region: S1_EF-P_repeat_2; cd05794 667014002316 RNA binding site [nucleotide binding]; other site 667014002317 Septum formation initiator; Region: DivIC; cl11433 667014002318 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 667014002319 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 667014002320 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 667014002321 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 667014002322 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 667014002323 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial...; Region: Sigma70_r4; cd06171 667014002324 DNA binding residues [nucleotide binding] 667014002325 RNA 2'-phosphotransferase, Tpt1 / KptA family; Region: PTS_2-RNA; pfam01885 667014002326 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 667014002327 tryptophan synthase, beta chain; Region: PLN02618 667014002328 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 667014002329 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014002330 catalytic residue [active] 667014002331 tryptophan synthase; Region: PLN02591 667014002332 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are...; Region: Tryptophan_synthase_alpha; cd04724 667014002333 substrate binding site [chemical binding]; other site 667014002334 active site 667014002335 catalytic residues [active] 667014002336 heterodimer interface [polypeptide binding]; other site 667014002337 Uncharacterized conserved protein [Function unknown]; Region: COG1565 667014002338 Uncharacterized ACR, COG1565; Region: DUF185; pfam02636 667014002339 Queuine tRNA-ribosyltransferase; Region: TGT; cl00409 667014002340 Preprotein translocase subunit; Region: YajC; cl00806 667014002341 cobyric acid synthase; Provisional; Region: PRK00784 667014002342 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 667014002343 catalytic triad [active] 667014002344 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 667014002345 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014002346 S-adenosylmethionine binding site [chemical binding]; other site 667014002347 Radical SAM; Region: Elp3; smart00729 667014002348 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014002349 FeS/SAM binding site; other site 667014002350 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 667014002351 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 667014002352 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 667014002353 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 667014002354 Rrf2 family protein; Region: rrf2_super; TIGR00738 667014002355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014002356 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 667014002357 active site 667014002358 cosubstrate binding site; other site 667014002359 substrate binding site [chemical binding]; other site 667014002360 catalytic site [active] 667014002361 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 667014002362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 667014002363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014002364 homodimer interface [polypeptide binding]; other site 667014002365 catalytic residue [active] 667014002366 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 667014002367 NAD synthetase; Provisional; Region: PRK13981 667014002368 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 667014002369 multimer interface [polypeptide binding]; other site 667014002370 active site 667014002371 catalytic triad [active] 667014002372 protein interface 1 [polypeptide binding]; other site 667014002373 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to...; Region: NAD_synthase; cd00553 667014002374 homodimer interface [polypeptide binding]; other site 667014002375 NAD binding pocket [chemical binding]; other site 667014002376 ATP binding pocket [chemical binding]; other site 667014002377 Mg binding site [ion binding]; other site 667014002378 active-site loop [active] 667014002379 CAAX amino terminal protease self- immunity; Region: Abi; cl00558 667014002380 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a...; Region: CobA_CobO_BtuR; cd00561 667014002381 Walker A motif; other site 667014002382 homodimer interface [polypeptide binding]; other site 667014002383 ATP binding site [chemical binding]; other site 667014002384 hydroxycobalamin binding site [chemical binding]; other site 667014002385 Walker B motif; other site 667014002386 CTP synthetase; Validated; Region: pyrG; PRK05380 667014002387 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer...; Region: CTGs; cd03113 667014002388 Catalytic site [active] 667014002389 Active site [active] 667014002390 UTP binding site [chemical binding]; other site 667014002391 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 667014002392 active site 667014002393 putative oxyanion hole; other site 667014002394 catalytic triad [active] 667014002395 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 667014002396 DNA repair protein RadA; Provisional; Region: PRK11823 667014002397 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 667014002398 Walker A motif/ATP binding site; other site 667014002399 ATP binding site [chemical binding]; other site 667014002400 Walker B motif; other site 667014002401 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 667014002402 putative homotetramer interface [polypeptide binding]; other site 667014002403 putative homodimer interface [polypeptide binding]; other site 667014002404 putative allosteric switch controlling residues; other site 667014002405 putative metal binding site [ion binding]; other site 667014002406 putative homodimer-homodimer interface [polypeptide binding]; other site 667014002407 4Fe-4S binding domain; Region: Fer4_5; pfam12801 667014002408 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 667014002409 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 667014002410 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 667014002411 glutamine binding [chemical binding]; other site 667014002412 catalytic triad [active] 667014002413 anthranilate synthase component I; Provisional; Region: PRK13565 667014002414 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 667014002415 chorismate binding enzyme; Region: Chorismate_bind; cl10555 667014002416 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 667014002417 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014002418 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 667014002419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014002420 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 667014002421 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 667014002422 E3 interaction surface; other site 667014002423 lipoyl attachment site [posttranslational modification]; other site 667014002424 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 667014002425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 667014002426 putative substrate translocation pore; other site 667014002427 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 667014002428 Outer membrane efflux protein; Region: OEP; pfam02321 667014002429 Outer membrane efflux protein; Region: OEP; pfam02321 667014002430 AMMECR1; Region: AMMECR1; cl00911 667014002431 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 667014002432 dimerization domain [polypeptide binding]; other site 667014002433 dimer interface [polypeptide binding]; other site 667014002434 catalytic residues [active] 667014002435 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 667014002436 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 667014002437 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 667014002438 catalytic residue [active] 667014002439 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 667014002440 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002441 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 667014002442 putative L-serine binding site [chemical binding]; other site 667014002443 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014002444 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014002445 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002446 binding surface 667014002447 TPR motif; other site 667014002448 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 667014002449 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 667014002450 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002451 TPR motif; other site 667014002452 binding surface 667014002453 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002454 binding surface 667014002455 TPR motif; other site 667014002456 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002457 binding surface 667014002458 TPR motif; other site 667014002459 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 667014002460 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002461 binding surface 667014002462 TPR motif; other site 667014002463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002464 binding surface 667014002465 TPR motif; other site 667014002466 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14463 667014002467 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014002468 FeS/SAM binding site; other site 667014002469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002470 Glucose inhibited division protein A; Region: GIDA; pfam01134 667014002471 trigger factor; Region: tig; TIGR00115 667014002472 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 667014002473 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 667014002474 oligomer interface [polypeptide binding]; other site 667014002475 active site residues [active] 667014002476 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 667014002477 ClpX C4-type zinc finger; Region: zf-C4_ClpX; cl05964 667014002478 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014002479 Walker A motif; other site 667014002480 ATP binding site [chemical binding]; other site 667014002481 Walker B motif; other site 667014002482 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 667014002483 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 667014002484 Found in ATP-dependent protease La (LON); Region: LON; smart00464 667014002485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014002486 Walker A motif; other site 667014002487 ATP binding site [chemical binding]; other site 667014002488 Walker B motif; other site 667014002489 arginine finger; other site 667014002490 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 667014002491 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 667014002492 putative active site [active] 667014002493 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 667014002494 dimer interface [polypeptide binding]; other site 667014002495 active site 667014002496 Deoxyhypusine synthase; Region: DS; cl00826 667014002497 Domain of unknown function (DUF369); Region: DUF369; cl00950 667014002498 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 667014002499 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 667014002500 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 667014002501 domain interfaces; other site 667014002502 active site 667014002503 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 667014002504 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations...; Region: HemD; cd06578 667014002505 active site 667014002506 Uroporphyrinogen-III synthase HemD; Region: HEM4; pfam02602 667014002507 Predicted permease; Region: DUF318; cl00487 667014002508 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 667014002509 cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235 667014002510 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 667014002511 catalytic residue [active] 667014002512 H+ Antiporter protein; Region: 2A0121; TIGR00900 667014002513 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 667014002514 putative substrate translocation pore; other site 667014002515 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 667014002516 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 667014002517 Recombination protein O N terminal; Region: RecO_N; pfam11967 667014002518 Recombination protein O C terminal; Region: RecO_C; pfam02565 667014002519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 667014002520 SurA N-terminal domain; Region: SurA_N; pfam09312 667014002521 PPIC-type PPIASE domain; Region: Rotamase; cl08278 667014002522 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 667014002523 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 667014002524 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 667014002525 ATP binding site [chemical binding]; other site 667014002526 putative Mg++ binding site [ion binding]; other site 667014002527 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 667014002528 nucleotide binding region [chemical binding]; other site 667014002529 ATP-binding site [chemical binding]; other site 667014002530 TRCF domain; Region: TRCF; cl04088 667014002531 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 667014002532 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014002533 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 667014002534 metal binding site [ion binding]; metal-binding site 667014002535 active site 667014002536 I-site; other site 667014002537 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 667014002538 Ribosomal prokaryotic L21 protein; Region: Ribosomal_L21p; cl00382 667014002539 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 667014002540 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014002541 FeS/SAM binding site; other site 667014002542 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 667014002543 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 667014002544 Substrate binding site [chemical binding]; other site 667014002545 Cupin domain; Region: Cupin_2; cl09118 667014002546 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases...; Region: PFK; cl00204 667014002547 6-phosphofructokinase; Provisional; Region: PRK03202 667014002548 active site 667014002549 ADP/pyrophosphate binding site [chemical binding]; other site 667014002550 dimerization interface [polypeptide binding]; other site 667014002551 allosteric effector site; other site 667014002552 fructose-1,6-bisphosphate binding site; other site 667014002553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002554 TIGR01777 family protein; Region: yfcH 667014002555 NAD(P) binding site [chemical binding]; other site 667014002556 active site 667014002557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014002558 dimer interface [polypeptide binding]; other site 667014002559 phosphorylation site [posttranslational modification] 667014002560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014002561 ATP binding site [chemical binding]; other site 667014002562 Mg2+ binding site [ion binding]; other site 667014002563 G-X-G motif; other site 667014002564 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 667014002565 nucleotide binding site/active site [active] 667014002566 HIT family signature motif; other site 667014002567 catalytic residue [active] 667014002568 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014002569 DsrC like protein; Region: DsrC; cl01101 667014002570 Protein of unknown function (DUF3373); Region: DUF3373; pfam11853 667014002571 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 667014002572 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014002573 FeS/SAM binding site; other site 667014002574 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 667014002575 active site 667014002576 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 667014002577 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 667014002578 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat1; cd02203 667014002579 dimerization interface [polypeptide binding]; other site 667014002580 ATP binding site [chemical binding]; other site 667014002581 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP...; Region: PurL_repeat2; cd02204 667014002582 dimerization interface [polypeptide binding]; other site 667014002583 ATP binding site [chemical binding]; other site 667014002584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002585 binding surface 667014002586 TPR motif; other site 667014002587 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 667014002588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002589 binding surface 667014002590 TPR motif; other site 667014002591 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 667014002592 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002593 binding surface 667014002594 TPR motif; other site 667014002595 type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521 667014002596 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002597 TPR motif; other site 667014002598 binding surface 667014002599 alternative sigma factor RpoH; Region: rpoH_proteo; TIGR02392 667014002600 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 667014002601 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002602 Flavin-dependent tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA [Cell cycle control, cell division, chromosome partitioning]; Region: GidA; COG0445 667014002603 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 667014002604 Domain of unknown function DUF21; Region: DUF21; pfam01595 667014002605 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 667014002606 Transporter associated domain; Region: CorC_HlyC; cl08393 667014002607 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 667014002608 Domain of unknown function DUF21; Region: DUF21; pfam01595 667014002609 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 667014002610 Transporter associated domain; Region: CorC_HlyC; cl08393 667014002611 Domain of unknown function DUF20; Region: UPF0118; cl00465 667014002612 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 667014002613 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 667014002614 DNA binding site [nucleotide binding] 667014002615 catalytic residue [active] 667014002616 H2TH interface [polypeptide binding]; other site 667014002617 putative catalytic residues [active] 667014002618 turnover-facilitating residue; other site 667014002619 intercalation triad [nucleotide binding]; other site 667014002620 8OG recognition residue [nucleotide binding]; other site 667014002621 putative reading head residues; other site 667014002622 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 667014002623 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 667014002624 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 667014002625 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 667014002626 HIGH motif; other site 667014002627 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 667014002628 active site 667014002629 KMSKS motif; other site 667014002630 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 667014002631 tRNA binding surface [nucleotide binding]; other site 667014002632 anticodon binding site; other site 667014002633 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 667014002634 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; cl11587 667014002635 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 667014002636 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014002637 ATP binding site [chemical binding]; other site 667014002638 Mg2+ binding site [ion binding]; other site 667014002639 G-X-G motif; other site 667014002640 Response regulator receiver domain; Region: Response_reg; pfam00072 667014002641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014002642 active site 667014002643 phosphorylation site [posttranslational modification] 667014002644 intermolecular recognition site; other site 667014002645 dimerization interface [polypeptide binding]; other site 667014002646 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 667014002647 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014002648 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014002649 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014002650 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 667014002651 tetramer interfaces [polypeptide binding]; other site 667014002652 binuclear metal-binding site [ion binding]; other site 667014002653 Protein of unknown function (DUF523); Region: DUF523; cl00733 667014002654 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 667014002655 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine...; Region: PurM; cd02196 667014002656 dimerization interface [polypeptide binding]; other site 667014002657 putative ATP binding site [chemical binding]; other site 667014002658 Archaeal-type gltB domain. This domain shares sequence similarity with a region of unknown function found in the large subunit of glutamate synthase, which is encoded by gltB and found in most bacteria and eukaryotes. It is predicted to be homologous...; Region: arch_gltB; cd00981 667014002659 putative subunit interface; other site 667014002660 Glutamine amidotransferases class-II (Gn-AT)_GlxB-type. GlxB is a glutamine amidotransferase-like protein of unknown function found in bacteria and archaea. GlxB has a structural fold similar to that of other class II glutamine amidotransferases...; Region: GlxB; cd01907 667014002661 putative active site [active] 667014002662 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 667014002663 4Fe-4S binding domain; Region: Fer4; cl02805 667014002664 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant...; Region: GltS_FMN; cd02808 667014002665 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 667014002666 active site 667014002667 FMN binding site [chemical binding]; other site 667014002668 substrate binding site [chemical binding]; other site 667014002669 3Fe-4S cluster binding site [ion binding]; other site 667014002670 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 667014002671 ATP-NAD kinase; Region: NAD_kinase; pfam01513 667014002672 YtxH-like protein; Region: YtxH; cl02079 667014002673 Protein of unknown function (DUF1015); Region: DUF1015; cl01715 667014002674 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 667014002675 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 667014002676 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014002677 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cd00522 667014002678 hemerythrin-like metal-binding domain; Region: hemeryth_dom; TIGR02481 667014002679 octamerization interface [polypeptide binding]; other site 667014002680 diferric-oxygen binding site [ion binding]; other site 667014002681 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 667014002682 N-acetyl-D-glucosamine binding site [chemical binding]; other site 667014002683 catalytic residue [active] 667014002684 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 667014002685 putative peptidoglycan binding site; other site 667014002686 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 667014002687 Lysin domain, found in a variety of enzymes involved in bacterial cell wall degradation. This domain may have a general peptidoglycan binding function; Region: LysM; cd00118 667014002688 putative peptidoglycan binding site; other site 667014002689 Staphylococcal nuclease homologues; Region: SNc; smart00318 667014002690 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 667014002691 Catalytic site; other site 667014002692 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 667014002693 Chorismate mutase type II; Region: CM_2; cl00693 667014002694 prephenate dehydratase; Provisional; Region: PRK11898 667014002695 Prephenate dehydratase; Region: PDT; pfam00800 667014002696 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 667014002697 putative L-Phe binding site [chemical binding]; other site 667014002698 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 667014002699 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 667014002700 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002701 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014002702 Cation transport protein; Region: TrkH; cl10514 667014002703 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 667014002704 Cation transport protein; Region: TrkH; cl10514 667014002705 Transmembrane amino acid transporter protein; Region: Aa_trans; cl00524 667014002706 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 667014002707 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 667014002708 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014002709 FeS/SAM binding site; other site 667014002710 TRAM domain; Region: TRAM; cl01282 667014002711 Uncharacterised ACR, COG1259; Region: DUF151; cl00553 667014002712 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 667014002713 hypothetical protein; Provisional; Region: PRK06361 667014002714 RNase P subunit p30; Region: RNase_P_p30; cl03389 667014002715 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 667014002716 UvrD/REP helicase; Region: UvrD-helicase; cl14126 667014002717 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002718 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 667014002719 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014002720 Nif-specific regulatory protein; Region: nifA; TIGR01817 667014002721 GAF domain; Region: GAF; cl00853 667014002722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014002723 Walker A motif; other site 667014002724 ATP binding site [chemical binding]; other site 667014002725 Walker B motif; other site 667014002726 arginine finger; other site 667014002727 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014002728 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 667014002729 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 667014002730 active site 667014002731 NTP binding site [chemical binding]; other site 667014002732 metal binding triad [ion binding]; metal-binding site 667014002733 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 667014002734 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 667014002735 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014002736 motif II; other site 667014002737 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014002738 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 667014002739 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 667014002740 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 667014002741 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 667014002742 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 667014002743 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 667014002744 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 667014002745 GTP-binding protein YchF; Reviewed; Region: PRK09601 667014002746 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014002747 G1 box; other site 667014002748 GTP/Mg2+ binding site [chemical binding]; other site 667014002749 G2 box; other site 667014002750 Switch I region; other site 667014002751 G3 box; other site 667014002752 Switch II region; other site 667014002753 G4 box; other site 667014002754 G5 box; other site 667014002755 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 667014002756 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 667014002757 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 667014002758 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014002759 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 667014002760 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 667014002761 minor groove reading motif; other site 667014002762 helix-hairpin-helix signature motif; other site 667014002763 substrate binding pocket [chemical binding]; other site 667014002764 active site 667014002765 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 667014002766 acetylornithine deacetylase; Provisional; Region: PRK08652 667014002767 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 667014002768 metal binding site [ion binding]; metal-binding site 667014002769 dimer interface [polypeptide binding]; other site 667014002770 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 667014002771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 667014002772 Coenzyme A binding pocket [chemical binding]; other site 667014002773 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 667014002774 active site 667014002775 metal binding site [ion binding]; metal-binding site 667014002776 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 667014002777 active site 667014002778 dimer interface [polypeptide binding]; other site 667014002779 metal binding site [ion binding]; metal-binding site 667014002780 LysE type translocator; Region: LysE; cl00565 667014002781 Fumarate hydratase (Fumerase); Region: Fumerase; cl00851 667014002782 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 667014002783 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 667014002784 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic...; Region: PRX_Typ2cys; cd03015 667014002785 decamer (pentamer of dimers) interface [polypeptide binding]; other site 667014002786 catalytic triad [active] 667014002787 dimer interface [polypeptide binding]; other site 667014002788 peroxidatic and resolving cysteines [active] 667014002789 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 667014002790 Rubredoxin; Region: Rubredoxin; pfam00301 667014002791 iron binding site [ion binding]; other site 667014002792 Transposase, Mutator family; Region: Transposase_mut; pfam00872 667014002793 MULE transposase domain; Region: MULE; pfam10551 667014002794 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the...; Region: HIT_like; cl00228 667014002795 nucleotide binding site/active site [active] 667014002796 HIT family signature motif; other site 667014002797 catalytic residue [active] 667014002798 PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394 667014002799 active site 667014002800 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 667014002801 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 667014002802 FAD binding pocket [chemical binding]; other site 667014002803 FAD binding motif [chemical binding]; other site 667014002804 phosphate binding motif [ion binding]; other site 667014002805 beta-alpha-beta structure motif; other site 667014002806 NAD binding pocket [chemical binding]; other site 667014002807 Iron coordination center [ion binding]; other site 667014002808 imidazole glycerol phosphate synthase hisHF; Region: PLN02617 667014002809 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 667014002810 putative active site [active] 667014002811 oxyanion strand; other site 667014002812 catalytic triad [active] 667014002813 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)-formimino-5-; Region: HisF; cd04731 667014002814 substrate binding site [chemical binding]; other site 667014002815 glutamase interaction surface [polypeptide binding]; other site 667014002816 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 667014002817 pyruvate carboxylase subunit B; Validated; Region: PRK09282 667014002818 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 667014002819 active site 667014002820 catalytic residues [active] 667014002821 metal binding site [ion binding]; metal-binding site 667014002822 homodimer binding site [polypeptide binding]; other site 667014002823 Conserved carboxylase domain; Region: PYC_OADA; pfam02436 667014002824 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 667014002825 carboxyltransferase (CT) interaction site; other site 667014002826 biotinylation site [posttranslational modification]; other site 667014002827 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 667014002828 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 667014002829 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014002830 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 667014002831 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 667014002832 GAF domain; Region: GAF; cl00853 667014002833 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 667014002834 metal binding site [ion binding]; metal-binding site 667014002835 active site 667014002836 I-site; other site 667014002837 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 667014002838 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 667014002839 putative cation:proton antiport protein; Provisional; Region: PRK10669 667014002840 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002841 YacP-like NYN domain; Region: NYN_YacP; cl01491 667014002842 ParB-like partition proteins; Region: parB_part; TIGR00180 667014002843 ParB-like nuclease domain; Region: ParBc; cl02129 667014002844 KorB domain; Region: KorB; pfam08535 667014002845 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 667014002846 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 667014002847 P-loop; other site 667014002848 Magnesium ion binding site [ion binding]; other site 667014002849 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following...; Region: ParA; cd02042 667014002850 Magnesium ion binding site [ion binding]; other site 667014002851 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; cl00360 667014002852 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; cl04011 667014002853 Sporulation related domain; Region: SPOR; cl10051 667014002854 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 667014002855 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 667014002856 Walker A/P-loop; other site 667014002857 ATP binding site [chemical binding]; other site 667014002858 Q-loop/lid; other site 667014002859 ABC transporter signature motif; other site 667014002860 Walker B; other site 667014002861 D-loop; other site 667014002862 H-loop/switch region; other site 667014002863 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 667014002864 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 667014002865 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 667014002866 Walker A/P-loop; other site 667014002867 ATP binding site [chemical binding]; other site 667014002868 Q-loop/lid; other site 667014002869 ABC transporter signature motif; other site 667014002870 Walker B; other site 667014002871 D-loop; other site 667014002872 H-loop/switch region; other site 667014002873 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 667014002874 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 667014002875 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 667014002876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014002877 dimer interface [polypeptide binding]; other site 667014002878 conserved gate region; other site 667014002879 putative PBP binding loops; other site 667014002880 ABC-ATPase subunit interface; other site 667014002881 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 667014002882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014002883 dimer interface [polypeptide binding]; other site 667014002884 conserved gate region; other site 667014002885 putative PBP binding loops; other site 667014002886 ABC-ATPase subunit interface; other site 667014002887 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 667014002888 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 667014002889 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-...; Region: RIBOc; cd00593 667014002890 dimerization interface [polypeptide binding]; other site 667014002891 active site 667014002892 metal binding site [ion binding]; metal-binding site 667014002893 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase...; Region: DSRM; cd00048 667014002894 GTPase Era; Reviewed; Region: era; PRK00089 667014002895 Era subfamily. Era (E. coli Ras-like protein) is a multifunctional GTPase found in all bacteria except some eubacteria. It binds to the 16S ribosomal RNA (rRNA) of the 30S subunit and appears to play a role in the assembly of the 30S subunit...; Region: Era; cd04163 667014002896 G1 box; other site 667014002897 GTP/Mg2+ binding site [chemical binding]; other site 667014002898 Switch I region; other site 667014002899 G2 box; other site 667014002900 Switch II region; other site 667014002901 G3 box; other site 667014002902 G4 box; other site 667014002903 G5 box; other site 667014002904 K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains...; Region: KH-I; cl00098 667014002905 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 667014002906 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 667014002907 competence damage-inducible protein A; Provisional; Region: PRK00549 667014002908 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 667014002909 putative MPT binding site; other site 667014002910 Competence-damaged protein; Region: CinA; cl00666 667014002911 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 667014002912 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 667014002913 2',5' RNA ligase family; Region: 2_5_RNA_ligase; pfam02834 667014002914 dihydroorotase; Validated; Region: pyrC; PRK09357 667014002915 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 667014002916 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C...; Region: DHOase_IIa; cd01317 667014002917 active site 667014002918 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 667014002919 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 667014002920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014002921 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 667014002922 Ferritin-like domain; Region: Ferritin; pfam00210 667014002923 ferroxidase diiron center [ion binding]; other site 667014002924 acetylornithine aminotransferase; Provisional; Region: PRK02627 667014002925 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase...; Region: OAT_like; cd00610 667014002926 inhibitor-cofactor binding pocket; inhibition site 667014002927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014002928 catalytic residue [active] 667014002929 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 667014002930 DNA-binding site [nucleotide binding]; DNA binding site 667014002931 RNA-binding motif; other site 667014002932 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 667014002933 Ligand binding site [chemical binding]; other site 667014002934 oligomer interface [polypeptide binding]; other site 667014002935 Cupin domain; Region: Cupin_2; cl09118 667014002936 Phosphoribosyl-AMP cyclohydrolase; Region: PRA-CH; cl00344 667014002937 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 667014002938 ATP phosphoribosyltransferase; Region: HisG; cl15266 667014002939 HisG, C-terminal domain; Region: HisG_C; cl06867 667014002940 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002941 binding surface 667014002942 TPR motif; other site 667014002943 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002944 binding surface 667014002945 TPR motif; other site 667014002946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014002947 binding surface 667014002948 TPR motif; other site 667014002949 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 667014002950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 667014002951 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases and ATP sulphurylases. The domain forms a apha/beta/apha fold which binds to Adenosine group; Region: Alpha_ANH_like; cd01986 667014002952 Ligand Binding Site [chemical binding]; other site 667014002953 DNA polymerase III subunit beta; Validated; Region: PRK05643 667014002954 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the...; Region: beta_clamp; cd00140 667014002955 putative DNA binding surface [nucleotide binding]; other site 667014002956 dimer interface [polypeptide binding]; other site 667014002957 beta-clamp/clamp loader binding surface; other site 667014002958 beta-clamp/translesion DNA polymerase binding surface; other site 667014002959 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 667014002960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014002961 Mg2+ binding site [ion binding]; other site 667014002962 G-X-G motif; other site 667014002963 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are...; Region: TopoII_Trans_DNA_gyrase; cd00822 667014002964 anchoring element; other site 667014002965 dimer interface [polypeptide binding]; other site 667014002966 ATP binding site [chemical binding]; other site 667014002967 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of...; Region: TOPRIM_TopoIIA_GyrB; cd03366 667014002968 active site 667014002969 putative metal-binding site [ion binding]; other site 667014002970 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 667014002971 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 667014002972 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 667014002973 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; cl00397 667014002974 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl01000 667014002975 Cobalt transport protein; Region: CbiQ; cl00463 667014002976 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 667014002977 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 667014002978 Walker A/P-loop; other site 667014002979 ATP binding site [chemical binding]; other site 667014002980 Q-loop/lid; other site 667014002981 ABC transporter signature motif; other site 667014002982 Walker B; other site 667014002983 D-loop; other site 667014002984 H-loop/switch region; other site 667014002985 Flagellin N-methylase; Region: FliB; cl00497 667014002986 Domain of unknown function DUF143; Region: DUF143; cl00519 667014002987 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 667014002988 Sulfatase; Region: Sulfatase; cl10460 667014002989 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 667014002990 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 667014002991 AsmA family; Region: AsmA; pfam05170 667014002992 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 667014002993 Cation efflux family; Region: Cation_efflux; cl00316 667014002994 This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme; Region: NifX_NifB; cl00252 667014002995 hybrid cluster protein; Provisional; Region: PRK05290 667014002996 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014002997 ACS interaction site; other site 667014002998 CODH interaction site; other site 667014002999 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 667014003000 hybrid metal cluster; other site 667014003001 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 667014003002 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014003003 motif II; other site 667014003004 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014003005 FeS/SAM binding site; other site 667014003006 Predicted amidohydrolase [General function prediction only]; Region: COG0388 667014003007 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 667014003008 active site 667014003009 catalytic triad [active] 667014003010 dimer interface [polypeptide binding]; other site 667014003011 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 667014003012 active site 667014003013 nucleotide binding site [chemical binding]; other site 667014003014 HIGH motif; other site 667014003015 KMSKS motif; other site 667014003016 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 667014003017 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 667014003018 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic...; Region: Tryp_SPc; cl00149 667014003019 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 667014003020 protein binding site [polypeptide binding]; other site 667014003021 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 667014003022 protein binding site [polypeptide binding]; other site 667014003023 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cl00250 667014003024 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 667014003025 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl15258 667014003026 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 667014003027 Predicted exonuclease [DNA replication, recombination, and repair]; Region: COG3359 667014003028 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 667014003029 PPIC-type PPIASE domain; Region: Rotamase; cl08278 667014003030 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 667014003031 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 667014003032 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003033 GTPase CgtA; Reviewed; Region: obgE; PRK12299 667014003034 GTP1/OBG; Region: GTP1_OBG; pfam01018 667014003035 Obg subfamily. The Obg nucleotide binding protein subfamily has been implicated in stress response, chromosome partitioning, replication initiation, mycelium development, and sporulation. Obg proteins are among a large group of GTP binding proteins...; Region: Obg; cd01898 667014003036 G1 box; other site 667014003037 GTP/Mg2+ binding site [chemical binding]; other site 667014003038 Switch I region; other site 667014003039 G2 box; other site 667014003040 G3 box; other site 667014003041 Switch II region; other site 667014003042 G4 box; other site 667014003043 G5 box; other site 667014003044 gamma-glutamyl kinase; Provisional; Region: PRK05429 667014003045 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 667014003046 nucleotide binding site [chemical binding]; other site 667014003047 homotetrameric interface [polypeptide binding]; other site 667014003048 putative phosphate binding site [ion binding]; other site 667014003049 putative allosteric binding site; other site 667014003050 PUA domain; Region: PUA; cl00607 667014003051 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 667014003052 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014003053 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 667014003054 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 667014003055 active site 667014003056 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 667014003057 substrate binding site [chemical binding]; other site 667014003058 ATP binding site [chemical binding]; other site 667014003059 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; cl00398 667014003060 Putative modulator of DNA gyrase; Region: PmbA_TldD; pfam01523 667014003061 amidophosphoribosyltransferase; Region: purF; TIGR01134 667014003062 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 667014003063 active site 667014003064 tetramer interface [polypeptide binding]; other site 667014003065 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 667014003066 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 667014003067 4Fe-4S binding domain; Region: Fer4; cl02805 667014003068 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 667014003069 4Fe-4S binding domain; Region: Fer4; cl02805 667014003070 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 667014003071 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014003072 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 667014003073 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 667014003074 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 667014003075 Sodium:solute symporter family; Region: SSF; cl00456 667014003076 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 667014003077 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014003078 Ligand Binding Site [chemical binding]; other site 667014003079 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 667014003080 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 667014003081 Localisation of periplasmic protein complexes; Region: AMIN; pfam11741 667014003082 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 667014003083 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 667014003084 active site 667014003085 metal binding site [ion binding]; metal-binding site 667014003086 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 667014003087 MutS domain I; Region: MutS_I; pfam01624 667014003088 MutS domain II; Region: MutS_II; pfam05188 667014003089 MutS family domain IV; Region: MutS_IV; pfam05190 667014003090 MutS1 homolog in eukaryotes. The MutS protein initiates DNA mismatch repair by recognizing mispaired and unpaired bases embedded in duplex DNA and activating endo- and exonucleases to remove the mismatch. Members of the MutS family possess C-terminal...; Region: ABC_MutS1; cd03284 667014003091 Walker A/P-loop; other site 667014003092 ATP binding site [chemical binding]; other site 667014003093 Q-loop/lid; other site 667014003094 ABC transporter signature motif; other site 667014003095 Walker B; other site 667014003096 D-loop; other site 667014003097 H-loop/switch region; other site 667014003098 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 667014003099 Fe-S cluster binding site [ion binding]; other site 667014003100 active site 667014003101 Nif-specific regulatory protein; Region: nifA; TIGR01817 667014003102 GAF domain; Region: GAF; cl00853 667014003103 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003104 Walker A motif; other site 667014003105 ATP binding site [chemical binding]; other site 667014003106 Walker B motif; other site 667014003107 arginine finger; other site 667014003108 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014003109 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 667014003110 homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660 667014003111 active site 667014003112 catalytic residues [active] 667014003113 metal binding site [ion binding]; metal-binding site 667014003114 nitrogenase reductase; Reviewed; Region: nifH; PRK13233 667014003115 NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040 667014003116 Nucleotide-binding sites [chemical binding]; other site 667014003117 Switch I region of nucleotide binding site; other site 667014003118 Fe4S4 binding sites [ion binding]; other site 667014003119 Switch II region of nucleotide binding site; other site 667014003120 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014003121 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014003122 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014003123 FeS/SAM binding site; other site 667014003124 nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284 667014003125 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a molybdenum-...; Region: Nitrogenase_MoFe_alpha_like; cd01967 667014003126 Nitrogenase_MoFe_beta_like: Nitrogenase MoFe protein, beta subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen (N2) to ammonia. This group contains the beta subunits of component 1 of the three known genetically...; Region: Nitrogenase_MoFe_beta_like; cd01965 667014003127 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 667014003128 cyanate hydratase; Validated; Region: PRK02866 667014003129 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 667014003130 oligomer interface [polypeptide binding]; other site 667014003131 active site 667014003132 Nitrogenase_MoFe_alpha_like: Nitrogenase MoFe protein, alpha subunit_like. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. Three genetically distinct types of nitrogenase systems are known to exist: a molybdenum-...; Region: Nitrogenase_MoFe_alpha_like; cd01967 667014003133 Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148 667014003134 CGGC domain; Region: CGGC; cl02356 667014003135 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 667014003136 putative phosphate binding site [ion binding]; other site 667014003137 putative catalytic site [active] 667014003138 active site 667014003139 metal binding site A [ion binding]; metal-binding site 667014003140 DNA binding site [nucleotide binding] 667014003141 putative AP binding site [nucleotide binding]; other site 667014003142 putative metal binding site B [ion binding]; other site 667014003143 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 667014003144 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 667014003145 oligomer interface [polypeptide binding]; other site 667014003146 active site 667014003147 metal binding site [ion binding]; metal-binding site 667014003148 PAS domain S-box; Region: sensory_box; TIGR00229 667014003149 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014003150 putative active site [active] 667014003151 heme pocket [chemical binding]; other site 667014003152 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 667014003153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 667014003154 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 667014003155 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003157 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014003158 Ligand Binding Site [chemical binding]; other site 667014003159 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 667014003160 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 667014003161 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 667014003162 Pseudouridine synthases are responsible for the synthesis of pseudouridine from uracil in ribosomal RNA. The RsuA subfamily includes Pseudouridine Synthase similar to Ribosomal small subunit pseudouridine 516 synthase. Most of the proteins in this...; Region: PseudoU_synth_RsuA_like; cd02870 667014003163 active site 667014003164 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 667014003165 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 667014003166 active site 667014003167 Riboflavin kinase; Region: Flavokinase; cl03312 667014003168 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 667014003169 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 667014003170 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; cl03056 667014003171 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 667014003172 catalytic site [active] 667014003173 subunit interface [polypeptide binding]; other site 667014003174 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003175 Walker A motif; other site 667014003176 ATP binding site [chemical binding]; other site 667014003177 Walker B motif; other site 667014003178 thymidylate kinase; Validated; Region: tmk; PRK00698 667014003179 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting...; Region: TMPK; cd01672 667014003180 TMP-binding site; other site 667014003181 ATP-binding site [chemical binding]; other site 667014003182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 667014003183 Smr domain; Region: Smr; cl02619 667014003184 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 667014003185 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 667014003186 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 667014003187 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014003188 dimer interface [polypeptide binding]; other site 667014003189 phosphorylation site [posttranslational modification] 667014003190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014003191 ATP binding site [chemical binding]; other site 667014003192 Mg2+ binding site [ion binding]; other site 667014003193 G-X-G motif; other site 667014003194 Response regulator receiver domain; Region: Response_reg; pfam00072 667014003195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003196 active site 667014003197 phosphorylation site [posttranslational modification] 667014003198 intermolecular recognition site; other site 667014003199 dimerization interface [polypeptide binding]; other site 667014003200 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 667014003201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 667014003202 Zn2+ binding site [ion binding]; other site 667014003203 Mg2+ binding site [ion binding]; other site 667014003204 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014003205 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 667014003206 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 667014003207 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 667014003208 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 667014003209 metal binding triad; other site 667014003210 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 667014003211 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 667014003212 metal binding triad; other site 667014003213 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 667014003214 Response regulator receiver domain; Region: Response_reg; pfam00072 667014003215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003216 active site 667014003217 phosphorylation site [posttranslational modification] 667014003218 intermolecular recognition site; other site 667014003219 dimerization interface [polypeptide binding]; other site 667014003220 sensory histidine kinase AtoS; Provisional; Region: PRK11360 667014003221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014003222 dimer interface [polypeptide binding]; other site 667014003223 phosphorylation site [posttranslational modification] 667014003224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014003225 ATP binding site [chemical binding]; other site 667014003226 Mg2+ binding site [ion binding]; other site 667014003227 G-X-G motif; other site 667014003228 Response regulator receiver domain; Region: Response_reg; pfam00072 667014003229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003230 active site 667014003231 phosphorylation site [posttranslational modification] 667014003232 intermolecular recognition site; other site 667014003233 dimerization interface [polypeptide binding]; other site 667014003234 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 667014003235 FMN binding site [chemical binding]; other site 667014003236 dimer interface [polypeptide binding]; other site 667014003237 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 667014003238 TM-ABC transporter signature motif; other site 667014003239 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 667014003240 TM-ABC transporter signature motif; other site 667014003241 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014003242 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 667014003243 Polysaccharide deacetylase; Region: Polysacc_deac_1; cl12061 667014003244 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 667014003245 SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain. The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421 667014003246 selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527 667014003247 CPxP motif; other site 667014003248 DsrE/DsrF-like family; Region: DrsE; cl00672 667014003249 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 667014003250 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 667014003251 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 667014003252 catalytic residue [active] 667014003253 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 667014003254 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 667014003255 SmpB-tmRNA interface; other site 667014003256 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 667014003257 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003258 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 667014003259 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 667014003260 active site residue [active] 667014003261 Protein of unknown function (DUF2934); Region: DUF2934; pfam11154 667014003262 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 667014003263 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 667014003264 tetrathionate reductase subunit A; Provisional; Region: PRK14991 667014003265 The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758 667014003266 putative [Fe4-S4] binding site [ion binding]; other site 667014003267 putative molybdopterin cofactor binding site [chemical binding]; other site 667014003268 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-; Region: MopB_CT; cl09929 667014003269 molybdopterin cofactor binding site; other site 667014003270 Transglutaminase-like superfamily; Region: Transglut_core; cl10469 667014003271 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 667014003272 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 667014003273 active site 667014003274 metal binding site [ion binding]; metal-binding site 667014003275 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 667014003276 generic binding surface II; other site 667014003277 generic binding surface I; other site 667014003278 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 667014003279 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This...; Region: Alpha_ANH_like_II; cd01993 667014003280 Ligand Binding Site [chemical binding]; other site 667014003281 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 667014003282 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014003283 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 667014003284 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 667014003285 putative ligand binding site [chemical binding]; other site 667014003286 Putative glucose-1-phosphate thymidylyltransferase, C-terminal Left-handed parallel beta-Helix (LbH) domain: Proteins in this family show simlarity to glucose-1-phosphate adenylyltransferases in that they contain N-terminal catalytic domains that...; Region: LbH_G1P_TT_C_like; cd05636 667014003287 RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467 667014003288 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014003289 Walker A motif; other site 667014003290 ATP binding site [chemical binding]; other site 667014003291 Walker B motif; other site 667014003292 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 667014003293 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 667014003294 ligand binding site [chemical binding]; other site 667014003295 oligomer interface [polypeptide binding]; other site 667014003296 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 667014003297 dimer interface [polypeptide binding]; other site 667014003298 N-terminal domain interface [polypeptide binding]; other site 667014003299 sulfate 1 binding site; other site 667014003300 Family of unknown function (DUF500); Region: DUF500; cl01109 667014003301 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014003302 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 667014003303 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 667014003304 putative ligand binding site [chemical binding]; other site 667014003305 PAS domain S-box; Region: sensory_box; TIGR00229 667014003306 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 667014003307 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014003308 dimer interface [polypeptide binding]; other site 667014003309 phosphorylation site [posttranslational modification] 667014003310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014003311 ATP binding site [chemical binding]; other site 667014003312 Mg2+ binding site [ion binding]; other site 667014003313 G-X-G motif; other site 667014003314 Response regulator receiver domain; Region: Response_reg; pfam00072 667014003315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003316 active site 667014003317 phosphorylation site [posttranslational modification] 667014003318 intermolecular recognition site; other site 667014003319 dimerization interface [polypeptide binding]; other site 667014003320 ThiC family; Region: ThiC; cl08031 667014003321 ornithine carbamoyltransferase; Provisional; Region: PRK00779 667014003322 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 667014003323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003324 Inactivated superfamily I helicase [DNA replication, recombination, and repair]; Region: COG3893 667014003325 ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857 667014003326 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 667014003327 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014003328 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014003329 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 667014003330 PUA domain; Region: PUA; cl00607 667014003331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014003332 S-adenosylmethionine binding site [chemical binding]; other site 667014003333 hypothetical protein; Provisional; Region: PRK08609 667014003334 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 667014003335 active site 667014003336 primer binding site [nucleotide binding]; other site 667014003337 NTP binding site [chemical binding]; other site 667014003338 metal binding triad [ion binding]; metal-binding site 667014003339 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 667014003340 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 667014003341 eight transmembrane protein EpsH (proposed exosortase); Region: 8TM_EpsH; cl10495 667014003342 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 667014003343 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 667014003344 conserved cys residue [active] 667014003345 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 667014003346 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting...; Region: NAPRTase_A; cd01570 667014003347 active site 667014003348 Isochorismatase family; Region: Isochorismatase; pfam00857 667014003349 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 667014003350 catalytic triad [active] 667014003351 conserved cis-peptide bond; other site 667014003352 Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434 667014003353 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014003354 Transposase domain (DUF772); Region: DUF772; cl12084 667014003355 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 667014003356 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 667014003357 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 667014003358 active site 667014003359 ribulose/triose binding site [chemical binding]; other site 667014003360 phosphate binding site [ion binding]; other site 667014003361 substrate (anthranilate) binding pocket [chemical binding]; other site 667014003362 product (indole) binding pocket [chemical binding]; other site 667014003363 diaminopimelate decarboxylase; Region: lysA; TIGR01048 667014003364 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 667014003365 active site 667014003366 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 667014003367 substrate binding site [chemical binding]; other site 667014003368 catalytic residues [active] 667014003369 dimer interface [polypeptide binding]; other site 667014003370 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 667014003371 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 667014003372 Diaminopimelate epimerase; Region: DAP_epimerase; cl14668 667014003373 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 667014003374 dihydrodipicolinate synthase; Region: dapA; TIGR00674 667014003375 dimer interface [polypeptide binding]; other site 667014003376 active site 667014003377 catalytic residue [active] 667014003378 dihydrodipicolinate reductase; Provisional; Region: PRK00048 667014003379 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003380 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 667014003381 Transposase domain (DUF772); Region: DUF772; cl12084 667014003382 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 667014003383 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014003384 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003385 active site 667014003386 phosphorylation site [posttranslational modification] 667014003387 intermolecular recognition site; other site 667014003388 dimerization interface [polypeptide binding]; other site 667014003389 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003390 Walker A motif; other site 667014003391 ATP binding site [chemical binding]; other site 667014003392 Walker B motif; other site 667014003393 arginine finger; other site 667014003394 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014003395 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 667014003396 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014003397 dimer interface [polypeptide binding]; other site 667014003398 phosphorylation site [posttranslational modification] 667014003399 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 667014003400 Mechanosensitive ion channel; Region: MS_channel; pfam00924 667014003401 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 667014003402 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 667014003403 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 667014003404 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 667014003405 minor groove reading motif; other site 667014003406 helix-hairpin-helix signature motif; other site 667014003407 substrate binding pocket [chemical binding]; other site 667014003408 active site 667014003409 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 667014003410 N-ethylammeline chlorohydrolase; Provisional; Region: PRK09045 667014003411 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 667014003412 active site 667014003413 putative substrate binding pocket [chemical binding]; other site 667014003414 urease subunit alpha; Reviewed; Region: ureC; PRK13207 667014003415 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 667014003416 subunit interactions [polypeptide binding]; other site 667014003417 active site 667014003418 flap region; other site 667014003419 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_beta; cd00407 667014003420 gamma-beta subunit interface [polypeptide binding]; other site 667014003421 alpha-beta subunit interface [polypeptide binding]; other site 667014003422 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 667014003423 alpha-gamma subunit interface [polypeptide binding]; other site 667014003424 beta-gamma subunit interface [polypeptide binding]; other site 667014003425 GAF domain; Region: GAF; cl00853 667014003426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003427 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 667014003428 Walker A motif; other site 667014003429 ATP binding site [chemical binding]; other site 667014003430 Walker B motif; other site 667014003431 arginine finger; other site 667014003432 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014003433 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 667014003434 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 667014003435 putative ligand binding site [chemical binding]; other site 667014003436 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 667014003437 TM-ABC transporter signature motif; other site 667014003438 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 667014003439 TM-ABC transporter signature motif; other site 667014003440 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 667014003441 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 667014003442 Walker A/P-loop; other site 667014003443 ATP binding site [chemical binding]; other site 667014003444 Q-loop/lid; other site 667014003445 ABC transporter signature motif; other site 667014003446 Walker B; other site 667014003447 D-loop; other site 667014003448 H-loop/switch region; other site 667014003449 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 667014003450 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 667014003451 Walker A/P-loop; other site 667014003452 ATP binding site [chemical binding]; other site 667014003453 Q-loop/lid; other site 667014003454 ABC transporter signature motif; other site 667014003455 Walker B; other site 667014003456 D-loop; other site 667014003457 H-loop/switch region; other site 667014003458 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 667014003459 protein-L-isoaspartate O-methyltransferase; Provisional; Region: PRK13943 667014003460 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014003461 S-adenosylmethionine binding site [chemical binding]; other site 667014003462 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 667014003463 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003464 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 667014003465 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003466 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 667014003467 catalytic residues [active] 667014003468 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 667014003469 Flavoprotein; Region: Flavoprotein; cl08021 667014003470 DNA / pantothenate metabolism flavoprotein; Region: DFP; cl04410 667014003471 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 667014003472 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 667014003473 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 667014003474 active site 667014003475 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 667014003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014003477 S-adenosylmethionine binding site [chemical binding]; other site 667014003478 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 667014003479 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 667014003480 Walker A/P-loop; other site 667014003481 ATP binding site [chemical binding]; other site 667014003482 Q-loop/lid; other site 667014003483 ABC transporter signature motif; other site 667014003484 Walker B; other site 667014003485 D-loop; other site 667014003486 H-loop/switch region; other site 667014003487 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 667014003488 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 667014003489 FAD binding site [chemical binding]; other site 667014003490 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 667014003491 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014003492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003493 active site 667014003494 phosphorylation site [posttranslational modification] 667014003495 intermolecular recognition site; other site 667014003496 dimerization interface [polypeptide binding]; other site 667014003497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003498 Walker A motif; other site 667014003499 ATP binding site [chemical binding]; other site 667014003500 Walker B motif; other site 667014003501 arginine finger; other site 667014003502 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014003503 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 667014003504 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 667014003505 dimerization interface [polypeptide binding]; other site 667014003506 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014003507 putative active site [active] 667014003508 heme pocket [chemical binding]; other site 667014003509 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014003510 dimer interface [polypeptide binding]; other site 667014003511 phosphorylation site [posttranslational modification] 667014003512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014003513 ATP binding site [chemical binding]; other site 667014003514 Mg2+ binding site [ion binding]; other site 667014003515 G-X-G motif; other site 667014003516 NAD(P)H:flavin oxidoreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes...; Region: NADPH_oxidoreductase_1; cd02150 667014003517 putative FMN binding site [chemical binding]; other site 667014003518 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 667014003519 spermidine synthase; Provisional; Region: PRK00811 667014003520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014003521 ATP sulfurylase (sulfate adenylyltransferase) [Inorganic ion transport and metabolism]; Region: MET3; COG2046 667014003522 ATP-sulfurylase; Region: ATPS; cd00517 667014003523 active site 667014003524 HXXH motif; other site 667014003525 flexible loop; other site 667014003526 Protein of unknown function (DUF1343); Region: DUF1343; cl01598 667014003527 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 667014003528 DHH family; Region: DHH; pfam01368 667014003529 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 667014003530 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 667014003531 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 667014003532 ligand binding site [chemical binding]; other site 667014003533 oligomer interface [polypeptide binding]; other site 667014003534 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and rate-...; Region: LbH_G1P_AT_C; cd04651 667014003535 dimer interface [polypeptide binding]; other site 667014003536 N-terminal domain interface [polypeptide binding]; other site 667014003537 sulfate 1 binding site; other site 667014003538 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 667014003539 dimerization domain swap beta strand [polypeptide binding]; other site 667014003540 regulatory protein interface [polypeptide binding]; other site 667014003541 active site 667014003542 regulatory phosphorylation site [posttranslational modification]; other site 667014003543 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 667014003544 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 667014003545 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 667014003546 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl09155 667014003547 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 667014003548 mce related protein; Region: MCE; pfam02470 667014003549 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 667014003550 ABC (ATP-binding cassette) transport system involved in resistant to organic solvents; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds, like sugars, ions, peptides, and more complex...; Region: ABC_Org_Solvent_Resistant; cd03261 667014003551 Walker A/P-loop; other site 667014003552 ATP binding site [chemical binding]; other site 667014003553 Q-loop/lid; other site 667014003554 ABC transporter signature motif; other site 667014003555 Walker B; other site 667014003556 D-loop; other site 667014003557 H-loop/switch region; other site 667014003558 Domain of unknown function DUF140; Region: DUF140; cl00510 667014003559 Low molecular weight phosphatase family; Region: LMWPc; cd00115 667014003560 Active site [active] 667014003561 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014003562 FeS/SAM binding site; other site 667014003563 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 667014003564 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 667014003565 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 667014003566 active site 667014003567 Nuclease-related domain; Region: NERD; pfam08378 667014003568 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 667014003569 Coenzyme A binding pocket [chemical binding]; other site 667014003570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014003571 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014003572 Thymidylate synthase complementing protein; Region: Thy1; cl03630 667014003573 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 667014003574 trimer interface [polypeptide binding]; other site 667014003575 active site 667014003576 Uncharacterized conserved protein [Function unknown]; Region: COG1542 667014003577 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 667014003578 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 667014003579 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014003580 putative active site [active] 667014003581 heme pocket [chemical binding]; other site 667014003582 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 667014003583 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 667014003584 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014003585 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 667014003586 putative active site [active] 667014003587 heme pocket [chemical binding]; other site 667014003588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014003589 dimer interface [polypeptide binding]; other site 667014003590 phosphorylation site [posttranslational modification] 667014003591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014003592 ATP binding site [chemical binding]; other site 667014003593 Mg2+ binding site [ion binding]; other site 667014003594 G-X-G motif; other site 667014003595 Response regulator receiver domain; Region: Response_reg; pfam00072 667014003596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003597 active site 667014003598 phosphorylation site [posttranslational modification] 667014003599 intermolecular recognition site; other site 667014003600 dimerization interface [polypeptide binding]; other site 667014003601 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 667014003602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014003603 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 667014003604 excinuclease ABC subunit B; Provisional; Region: PRK05298 667014003605 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 667014003606 ATP binding site [chemical binding]; other site 667014003607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 667014003608 nucleotide binding region [chemical binding]; other site 667014003609 ATP-binding site [chemical binding]; other site 667014003610 Ultra-violet resistance protein B; Region: UvrB; pfam12344 667014003611 UvrB/uvrC motif; Region: UVR; pfam02151 667014003612 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 667014003613 active site 667014003614 Flagellin N-methylase; Region: FliB; cl00497 667014003615 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 667014003616 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 667014003617 catalytic core [active] 667014003618 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 667014003619 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014003620 HrcA protein C terminal domain; Region: HrcA; pfam01628 667014003621 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding...; Region: GrpE; cd00446 667014003622 dimer interface [polypeptide binding]; other site 667014003623 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 667014003624 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 667014003625 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 667014003626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014003627 S-adenosylmethionine binding site [chemical binding]; other site 667014003628 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 667014003629 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 667014003630 active site 667014003631 (T/H)XGH motif; other site 667014003632 Protein of unknown function (DUF3108); Region: DUF3108; pfam11306 667014003633 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II)...; Region: Aldolase_II; cl00214 667014003634 intersubunit interface [polypeptide binding]; other site 667014003635 active site 667014003636 Zn2+ binding site [ion binding]; other site 667014003637 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 667014003638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003639 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 667014003640 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003641 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 667014003642 putative active site pocket [active] 667014003643 4-fold oligomerization interface [polypeptide binding]; other site 667014003644 metal binding residues [ion binding]; metal-binding site 667014003645 3-fold/trimer interface [polypeptide binding]; other site 667014003646 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 667014003647 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 667014003648 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014003649 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 667014003650 AIR carboxylase; Region: AIRC; cl00310 667014003651 EamA-like transporter family; Region: EamA; cl01037 667014003652 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 667014003653 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003654 NAD(P) binding site [chemical binding]; other site 667014003655 active site 667014003656 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 667014003657 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate...; Region: GFAT; cd00714 667014003658 glutaminase active site [active] 667014003659 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 667014003660 dimer interface [polypeptide binding]; other site 667014003661 active site 667014003662 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 667014003663 dimer interface [polypeptide binding]; other site 667014003664 active site 667014003665 sugar transferase, PEP-CTERM system associated; Region: EpsB_2; TIGR03013 667014003666 Bacterial sugar transferase; Region: Bac_transf; cl00939 667014003667 exopolysaccharide/PEPCTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 667014003668 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 667014003669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003670 Walker A motif; other site 667014003671 ATP binding site [chemical binding]; other site 667014003672 Walker B motif; other site 667014003673 arginine finger; other site 667014003674 Chain length determinant protein; Region: Wzz; cl01623 667014003675 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 667014003676 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; cl12051 667014003677 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 667014003678 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 667014003679 SLBB domain; Region: SLBB; pfam10531 667014003680 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins...; Region: HNHc; cd00085 667014003681 active site 667014003682 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 667014003683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014003684 FeS/SAM binding site; other site 667014003685 DNA gyrase subunit A; Validated; Region: PRK05560 667014003686 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in...; Region: TOP4c; cd00187 667014003687 CAP-like domain; other site 667014003688 Active site [active] 667014003689 primary dimer interface [polypeptide binding]; other site 667014003690 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 667014003691 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 667014003692 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 667014003693 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 667014003694 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 667014003695 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014003696 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 667014003697 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003698 Domain of unknown function (DUF329); Region: DUF329; cl01144 667014003699 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014003700 Ligand Binding Site [chemical binding]; other site 667014003701 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014003702 Ligand Binding Site [chemical binding]; other site 667014003703 recombination protein RecR; Reviewed; Region: recR; PRK00076 667014003704 RecR protein; Region: RecR; pfam02132 667014003705 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 667014003706 putative active site [active] 667014003707 putative metal-binding site [ion binding]; other site 667014003708 tetramer interface [polypeptide binding]; other site 667014003709 Uncharacterised BCR, YbaB family COG0718; Region: DUF149; cl00494 667014003710 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 667014003711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003712 Walker A motif; other site 667014003713 ATP binding site [chemical binding]; other site 667014003714 Walker B motif; other site 667014003715 arginine finger; other site 667014003716 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 667014003717 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 667014003718 AzlC protein; Region: AzlC; cl00570 667014003719 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 667014003720 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 667014003721 non-specific DNA binding site [nucleotide binding]; other site 667014003722 salt bridge; other site 667014003723 sequence-specific DNA binding site [nucleotide binding]; other site 667014003724 Cupin domain; Region: Cupin_2; cl09118 667014003725 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495 667014003726 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014003727 FeS/SAM binding site; other site 667014003728 Peptidase family M48; Region: Peptidase_M48; cl12018 667014003729 signal recognition particle protein; Provisional; Region: PRK10867 667014003730 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 667014003731 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 667014003732 P loop; other site 667014003733 GTP binding site [chemical binding]; other site 667014003734 Signal peptide binding domain; Region: SRP_SPB; pfam02978 667014003735 Ribosomal protein S16; Region: Ribosomal_S16; cl00368 667014003736 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837; cl00794 667014003737 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 667014003738 RimM N-terminal domain; Region: RimM; pfam01782 667014003739 Photosynthetic reaction center (RC) complex, subunit H; RC is an integral membrane protein-pigment complex which catalyzes light-induced reduction of ubiquinone to ubiquinol, generating a transmembrane electrochemical gradient of protons used to...; Region: PRCH; cl09959 667014003740 acetyl-CoA synthetase; Provisional; Region: PRK00174 667014003741 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 667014003742 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 667014003743 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 667014003744 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 667014003745 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 667014003746 ABC-type transport system involved in Fe-S cluster assembly, ATPase component. Biosynthesis of iron-sulfur clusters (Fe-S) depends on multiprotein systems. The SUF system of E. coli and Erwinia chrysanthemi is important for Fe-S biogenesis under...; Region: ABC_FeS_Assembly; cd03217 667014003747 Walker A/P-loop; other site 667014003748 ATP binding site [chemical binding]; other site 667014003749 Q-loop/lid; other site 667014003750 ABC transporter signature motif; other site 667014003751 Walker B; other site 667014003752 D-loop; other site 667014003753 H-loop/switch region; other site 667014003754 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 667014003755 alanine racemase; Reviewed; Region: alr; PRK00053 667014003756 active site 667014003757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 667014003758 dimer interface [polypeptide binding]; other site 667014003759 substrate binding site [chemical binding]; other site 667014003760 catalytic residues [active] 667014003761 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 667014003762 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 667014003763 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 667014003764 heme-binding residues [chemical binding]; other site 667014003765 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 667014003766 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 667014003767 heme-binding residues [chemical binding]; other site 667014003768 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 667014003769 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 667014003770 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014003771 putative active site [active] 667014003772 heme pocket [chemical binding]; other site 667014003773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003774 Walker A motif; other site 667014003775 ATP binding site [chemical binding]; other site 667014003776 Walker B motif; other site 667014003777 arginine finger; other site 667014003778 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014003779 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 667014003780 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 667014003781 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 667014003782 DNA binding residues [nucleotide binding] 667014003783 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 667014003784 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 667014003785 The YihA (EngB) subfamily. This subfamily of GTPases is typified by the E. coli YihA, an essential protein involved in cell division control. YihA and its orthologs are small proteins that typically contain less than 200 amino acid residues and...; Region: YihA_EngB; cd01876 667014003786 G1 box; other site 667014003787 GTP/Mg2+ binding site [chemical binding]; other site 667014003788 Switch I region; other site 667014003789 G2 box; other site 667014003790 G3 box; other site 667014003791 Switch II region; other site 667014003792 G4 box; other site 667014003793 G5 box; other site 667014003794 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003795 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 667014003796 Walker A motif; other site 667014003797 ATP binding site [chemical binding]; other site 667014003798 Walker B motif; other site 667014003799 arginine finger; other site 667014003800 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 667014003801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014003802 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 667014003803 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014003804 Beta-Casp domain; Region: Beta-Casp; cl12567 667014003805 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 667014003806 PilZ domain; Region: PilZ; cl01260 667014003807 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 667014003808 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 667014003809 Type IV leader peptidase family; Region: Peptidase_A24; cl02077 667014003810 phosphodiesterase; Provisional; Region: PRK12704 667014003811 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014003812 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 667014003813 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 667014003814 putative active site [active] 667014003815 metal binding site [ion binding]; metal-binding site 667014003816 homodimer binding site [polypeptide binding]; other site 667014003817 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 667014003818 metal binding site 2 [ion binding]; metal-binding site 667014003819 putative DNA binding helix; other site 667014003820 metal binding site 1 [ion binding]; metal-binding site 667014003821 dimer interface [polypeptide binding]; other site 667014003822 structural Zn2+ binding site [ion binding]; other site 667014003823 FeoA domain; Region: FeoA; cl00838 667014003824 integron integrase; Region: integrase_gron; TIGR02249 667014003825 DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and a secondary target called the attC (or 59-base element)...; Region: INT_IntI; cd01193 667014003826 Int/Topo IB signature motif; other site 667014003827 Transposase domain (DUF772); Region: DUF772; cl12084 667014003828 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 667014003829 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 667014003830 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 667014003831 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-...; Region: SIS_Kpsf; cd05014 667014003832 putative active site [active] 667014003833 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 667014003834 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 667014003835 glycogen/starch synthases, ADP-glucose type; Region: glgA; TIGR02095 667014003836 ADP-binding pocket [chemical binding]; other site 667014003837 homodimer interface [polypeptide binding]; other site 667014003838 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 667014003839 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 667014003840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014003841 catalytic residue [active] 667014003842 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 667014003843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014003844 Walker A motif; other site 667014003845 ATP binding site [chemical binding]; other site 667014003846 Walker B motif; other site 667014003847 arginine finger; other site 667014003848 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014003849 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014003850 Uncharacterized conserved protein [Function unknown]; Region: COG0585 667014003851 PseudoU_synth: Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi). Pseudouridine synthases contains the RsuA/RluD, TruA, TruB and TruD families. This group consists of...; Region: PseudoU_synth; cl00130 667014003852 active site 667014003853 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 667014003854 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014003855 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 667014003856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 667014003857 nucleotide binding region [chemical binding]; other site 667014003858 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 667014003859 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 667014003860 Putative periplasminc binding protein (DUF178); Region: DUF178; cl15271 667014003861 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 667014003862 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 667014003863 PhoU domain; Region: PhoU; pfam01895 667014003864 PhoU domain; Region: PhoU; pfam01895 667014003865 Protein of unknown function DUF47; Region: PhoU_div; pfam01865 667014003866 phosphate ABC transporter, ATP-binding protein; Region: 3a0107s01c2; TIGR00972 667014003867 Phosphate uptake is of fundamental importance in the cell physiology of bacteria because phosphate is required as a nutrient. The Pst system of E. coli comprises four distinct subunits encoded by the pstS, pstA, pstB, and pstC genes. The PstS protein...; Region: ABC_PstB_phosphate_transporter; cd03260 667014003868 Walker A/P-loop; other site 667014003869 ATP binding site [chemical binding]; other site 667014003870 Q-loop/lid; other site 667014003871 ABC transporter signature motif; other site 667014003872 Walker B; other site 667014003873 D-loop; other site 667014003874 H-loop/switch region; other site 667014003875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014003876 dimer interface [polypeptide binding]; other site 667014003877 conserved gate region; other site 667014003878 putative PBP binding loops; other site 667014003879 ABC-ATPase subunit interface; other site 667014003880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014003881 dimer interface [polypeptide binding]; other site 667014003882 conserved gate region; other site 667014003883 putative PBP binding loops; other site 667014003884 ABC-ATPase subunit interface; other site 667014003885 Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768 667014003886 Uncharacterized conserved protein [Function unknown]; Region: COG2006 667014003887 4Fe-4S binding domain; Region: Fer4; cl02805 667014003888 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 667014003889 Protein of unknown function DUF82; Region: DUF82; pfam01927 667014003890 Nickel uptake substrate-specific transmembrane region; Region: NikM; pfam10670 667014003891 ABC-type Co2+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CbiK; COG5266 667014003892 Beta-lactamase; Region: Beta-lactamase; cl01009 667014003893 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 667014003894 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 667014003895 dimerization interface [polypeptide binding]; other site 667014003896 domain crossover interface; other site 667014003897 redox-dependent activation switch; other site 667014003898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014003899 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 667014003900 argininosuccinate lyase; Provisional; Region: PRK00855 667014003901 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 667014003902 active sites [active] 667014003903 tetramer interface [polypeptide binding]; other site 667014003904 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 667014003905 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: HisRS-like_core; cd00773 667014003906 dimer interface [polypeptide binding]; other site 667014003907 motif 1; other site 667014003908 active site 667014003909 motif 2; other site 667014003910 motif 3; other site 667014003911 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 667014003912 anticodon binding site; other site 667014003913 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 667014003914 PilZ domain; Region: PilZ; cl01260 667014003915 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 667014003916 ATP synthase I chain; Region: ATP_synt_I; cl09170 667014003917 ATP synthase A chain; Region: ATP-synt_A; cl00413 667014003918 ATP synthase subunit C; Region: ATP-synt_C; cl00466 667014003919 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 667014003920 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 667014003921 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014003922 binding surface 667014003923 TPR motif; other site 667014003924 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 667014003925 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are...; Region: ACD_sHsps-like; cd06464 667014003926 putative dimer interface [polypeptide binding]; other site 667014003927 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 667014003928 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 667014003929 putative active site [active] 667014003930 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014003931 active site 667014003932 motif I; other site 667014003933 motif II; other site 667014003934 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 667014003935 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 667014003936 putative active site [active] 667014003937 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1'-...; Region: HisA; cd04732 667014003938 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 667014003939 catalytic residues [active] 667014003940 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 667014003941 RNB domain; Region: RNB; pfam00773 667014003942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014003943 Response regulator receiver domain; Region: Response_reg; pfam00072 667014003944 active site 667014003945 phosphorylation site [posttranslational modification] 667014003946 intermolecular recognition site; other site 667014003947 dimerization interface [polypeptide binding]; other site 667014003948 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 667014003949 metal binding site [ion binding]; metal-binding site 667014003950 active site 667014003951 I-site; other site 667014003952 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or...; Region: Nudix_Hydrolase; cl00447 667014003953 nudix motif; other site 667014003954 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 667014003955 active site 667014003956 dimerization interface [polypeptide binding]; other site 667014003957 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 667014003958 Initiation factor 2 subunit family; Region: IF-2B; pfam01008 667014003959 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 667014003960 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 667014003961 GatB domain; Region: GatB_Yqey; cl11497 667014003962 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 667014003963 octamerization interface [polypeptide binding]; other site 667014003964 hemerythrin-like metal-binding domain; Region: hemeryth_dom; TIGR02481 667014003965 diferric-oxygen binding site [ion binding]; other site 667014003966 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 667014003967 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 667014003968 HIGH motif; other site 667014003969 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 667014003970 active site 667014003971 KMSKS motif; other site 667014003972 Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361 667014003973 putative ligand binding pocket/active site [active] 667014003974 putative metal binding site [ion binding]; other site 667014003975 rod shape-determining protein MreB; Provisional; Region: PRK13927 667014003976 Actin; An ubiquitous protein involved in the formation of filaments that are a major component of the cytoskeleton. Interaction with myosin provides the basis of muscular contraction and many aspects of cell motility. Each actin protomer binds one...; Region: ACTIN; cl11528 667014003977 ATP binding site [chemical binding]; other site 667014003978 gelsolin binding site; other site 667014003979 profilin binding site; other site 667014003980 rod shape-determining protein MreC; Region: MreC; pfam04085 667014003981 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 667014003982 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 667014003983 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl01039 667014003984 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 667014003985 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 667014003986 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 667014003987 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 667014003988 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl07975 667014003989 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 667014003990 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 667014003991 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 667014003992 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 667014003993 beta subunit interaction interface [polypeptide binding]; other site 667014003994 Walker A motif; other site 667014003995 ATP binding site [chemical binding]; other site 667014003996 Walker B motif; other site 667014003997 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 667014003998 ATP synthase; Region: ATP-synt; cl00365 667014003999 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 667014004000 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 667014004001 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 667014004002 alpha subunit interaction interface [polypeptide binding]; other site 667014004003 Walker A motif; other site 667014004004 ATP binding site [chemical binding]; other site 667014004005 Walker B motif; other site 667014004006 inhibitor binding site; inhibition site 667014004007 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 667014004008 ATP synthase, Delta/Epsilon chain, beta-sandwich domain; Region: ATP-synt_DE_N; cl10033 667014004009 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 667014004010 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 667014004011 Substrate binding site [chemical binding]; other site 667014004012 Mg++ binding site [ion binding]; other site 667014004013 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 667014004014 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 667014004015 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 667014004016 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014004017 CRISPR-associated protein (Cas_Cas02710); Region: Cas_Cas02710; pfam09670 667014004018 CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09747 667014004019 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 667014004020 CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cl01317 667014004021 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 667014004022 Uncharacterized conserved protein [Function unknown]; Region: COG1656; cl09136 667014004023 Protein of unknown function (DUF433); Region: DUF433; cl01030 667014004024 CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cl12075 667014004025 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679 667014004026 CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577 667014004027 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl00592 667014004028 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 667014004029 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 667014004030 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014004031 binding surface 667014004032 TPR motif; other site 667014004033 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 667014004034 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 667014004035 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 667014004036 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 667014004037 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 667014004038 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 667014004039 Domain of unknown function DUF39; Region: DUF39; cl14897 667014004040 FOG: CBS domain [General function prediction only]; Region: COG0517 667014004041 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc; cd04584 667014004042 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 667014004043 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 667014004044 FGGY family of carbohydrate kinases, N-terminal domain; Region: FGGY_N; cl09121 667014004045 CoA enzyme activase uncharacterised domain (DUF2229); Region: DUF2229; cl12083 667014004046 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 667014004047 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 667014004048 putative active site [active] 667014004049 putative CoA binding site [chemical binding]; other site 667014004050 nudix motif; other site 667014004051 metal binding site [ion binding]; metal-binding site 667014004052 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 667014004053 oligomeric interface; other site 667014004054 homodimer interface [polypeptide binding]; other site 667014004055 putative active site [active] 667014004056 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 667014004057 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014004058 S-adenosylmethionine binding site [chemical binding]; other site 667014004059 Protein of unknown function DUF262; Region: DUF262; cl14890 667014004060 Uncharacterized conserved protein (DUF2081); Region: DUF2081; cl09179 667014004061 integron integrase; Region: integrase_gron; TIGR02249 667014004062 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 667014004063 DNA binding site [nucleotide binding] 667014004064 Int/Topo IB signature motif; other site 667014004065 active site 667014004066 hydrogenase, Fe-only; Region: Fe_only_hydrog; TIGR02512 667014004067 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 667014004068 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; cl03503 667014004069 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004070 Active site [active] 667014004071 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 667014004072 SRP54-type protein, helical bundle domain; Region: SRP54_N; cl03758 667014004073 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 667014004074 GTP binding site [chemical binding]; other site 667014004075 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 667014004076 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and alpha-...; Region: BCAT_beta_family; cd01557 667014004077 homodimer interface [polypeptide binding]; other site 667014004078 substrate-cofactor binding pocket; other site 667014004079 catalytic residue [active] 667014004080 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004081 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 667014004082 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004083 Walker A/P-loop; other site 667014004084 ATP binding site [chemical binding]; other site 667014004085 Q-loop/lid; other site 667014004086 ABC transporter signature motif; other site 667014004087 Walker B; other site 667014004088 D-loop; other site 667014004089 H-loop/switch region; other site 667014004090 ABC-2 type transporter; Region: ABC2_membrane; cl11417 667014004091 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 667014004092 23S rRNA interface [nucleotide binding]; other site 667014004093 L3 interface [polypeptide binding]; other site 667014004094 Ribosomal protein S9/S16; Region: Ribosomal_S9; cl00334 667014004095 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 667014004096 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014004097 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 667014004098 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 667014004099 PseudoU_synth_EcTruA: Pseudouridine synthase, Escherichia coli TruA like. This group consists of eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA, Pseudomonas aeruginosa truA and human pseudouridine synthase-like 1 (PUSL1)...; Region: PseudoU_synth_EcTruA; cd02570 667014004100 dimerization interface 3.5A [polypeptide binding]; other site 667014004101 active site 667014004102 hypothetical protein; Validated; Region: PRK07682 667014004103 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 667014004104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014004105 homodimer interface [polypeptide binding]; other site 667014004106 catalytic residue [active] 667014004107 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 667014004108 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 667014004109 N-terminal plug; other site 667014004110 ligand-binding site [chemical binding]; other site 667014004111 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 667014004112 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014004113 dimer interface [polypeptide binding]; other site 667014004114 phosphorylation site [posttranslational modification] 667014004115 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014004116 ATP binding site [chemical binding]; other site 667014004117 Mg2+ binding site [ion binding]; other site 667014004118 G-X-G motif; other site 667014004119 Response regulator receiver domain; Region: Response_reg; pfam00072 667014004120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014004121 active site 667014004122 phosphorylation site [posttranslational modification] 667014004123 intermolecular recognition site; other site 667014004124 dimerization interface [polypeptide binding]; other site 667014004125 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 667014004126 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 667014004127 active site 667014004128 HIGH motif; other site 667014004129 nucleotide binding site [chemical binding]; other site 667014004130 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 667014004131 active site 667014004132 KMSKS motif; other site 667014004133 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 667014004134 tRNA binding surface [nucleotide binding]; other site 667014004135 anticodon binding site; other site 667014004136 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 667014004137 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 667014004138 lipoprotein signal peptidase; Provisional; Region: PRK14787 667014004139 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts...; Region: cpn10; cd00320 667014004140 oligomerisation interface [polypeptide binding]; other site 667014004141 mobile loop; other site 667014004142 roof hairpin; other site 667014004143 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 667014004144 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 667014004145 ring oligomerisation interface [polypeptide binding]; other site 667014004146 ATP/Mg binding site [chemical binding]; other site 667014004147 stacking interactions; other site 667014004148 hinge regions; other site 667014004149 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 667014004150 Peptidase family M48; Region: Peptidase_M48; cl12018 667014004151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014004152 TPR motif; other site 667014004153 binding surface 667014004154 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014004155 binding surface 667014004156 TPR motif; other site 667014004157 elongation factor G; Reviewed; Region: PRK00007 667014004158 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 667014004159 G1 box; other site 667014004160 putative GEF interaction site [polypeptide binding]; other site 667014004161 GTP/Mg2+ binding site [chemical binding]; other site 667014004162 Switch I region; other site 667014004163 G2 box; other site 667014004164 G3 box; other site 667014004165 Switch II region; other site 667014004166 G4 box; other site 667014004167 G5 box; other site 667014004168 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 667014004169 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 667014004170 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 667014004171 Domain of unknown function (DUF205); Region: DUF205; cl00410 667014004172 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014004173 FeS assembly SUF system regulator, gammaproteobacterial; Region: suf_reg_Xantho; TIGR02944 667014004174 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014004175 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 667014004176 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 667014004177 Protein of unknown function (DUF429); Region: DUF429; cl12046 667014004178 hypothetical protein; Validated; Region: PRK08223 667014004179 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014004180 ATP binding site [chemical binding]; other site 667014004181 substrate interface [chemical binding]; other site 667014004182 ApbE family; Region: ApbE; cl00643 667014004183 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 667014004184 NeuB family; Region: NeuB; cl00496 667014004185 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 667014004186 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 667014004187 OstA-like protein; Region: OstA; cl00844 667014004188 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 667014004189 The ABC transporters belonging to the YhbG family are similar to members of the Mj1267_LivG family, which is involved in the transport of branched-chain amino acids. The genes yhbG and yhbN are located in a single operon and may function together in...; Region: ABC_YhbG; cd03218 667014004190 Walker A/P-loop; other site 667014004191 ATP binding site [chemical binding]; other site 667014004192 Q-loop/lid; other site 667014004193 ABC transporter signature motif; other site 667014004194 Walker B; other site 667014004195 D-loop; other site 667014004196 H-loop/switch region; other site 667014004197 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 667014004198 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 667014004199 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 667014004200 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 667014004201 RaiA ('ribosome-associated inhibitor A', also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal A site...; Region: RaiA; cd00552 667014004202 30S subunit binding site; other site 667014004203 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 667014004204 active site 667014004205 phosphorylation site [posttranslational modification] 667014004206 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004207 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_man; cd00006 667014004208 active pocket/dimerization site; other site 667014004209 active site 667014004210 phosphorylation site [posttranslational modification] 667014004211 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 667014004212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 667014004213 Coenzyme A binding pocket [chemical binding]; other site 667014004214 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 667014004215 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 667014004216 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 667014004217 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 667014004218 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 667014004219 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; cl15267 667014004220 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 667014004221 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 667014004222 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 667014004223 substrate binding site [chemical binding]; other site 667014004224 hinge regions; other site 667014004225 ADP binding site [chemical binding]; other site 667014004226 catalytic site [active] 667014004227 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 667014004228 substrate binding site [chemical binding]; other site 667014004229 dimer interface [polypeptide binding]; other site 667014004230 catalytic triad [active] 667014004231 Preprotein translocase SecG subunit; Region: SecG; cl09123 667014004232 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 667014004233 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 667014004234 tRNA; other site 667014004235 putative tRNA binding site [nucleotide binding]; other site 667014004236 putative NADP binding site [chemical binding]; other site 667014004237 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 667014004238 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 667014004239 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014004240 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 667014004241 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 667014004242 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 667014004243 Ion channel; Region: Ion_trans_2; cl11596 667014004244 pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029 667014004245 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 667014004246 2-oxoacid:acceptor oxidoreductase, delta subunit, pyruvate/2-ketoisovalerate family; Region: PorD_KorD; TIGR02179 667014004247 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014004248 pyruvate ferredoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK08367 667014004249 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 667014004250 dimer interface [polypeptide binding]; other site 667014004251 PYR/PP interface [polypeptide binding]; other site 667014004252 TPP binding site [chemical binding]; other site 667014004253 substrate binding site [chemical binding]; other site 667014004254 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 667014004255 TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea and some hyperthermophilic bacteria. PFOR catalyzes the...; Region: TPP_PFOR_porB_like; cd03376 667014004256 TPP-binding site [chemical binding]; other site 667014004257 putative dimer interface [polypeptide binding]; other site 667014004258 carbon-monoxide dehydrogenase, catalytic subunit; Region: CO_DH_cata; TIGR01702 667014004259 Carbon monoxide dehydrogenase (CODH) is found in acetogenic and methanogenic organisms and is responsible for the synthesis and breakdown of acetyl-CoA, respectively. CODH has two types of metal clusters, a cubane [Fe4-S4] center (B-cluster) similar to...; Region: CODH; cd01915 667014004260 ACS interaction site; other site 667014004261 CODH interaction site; other site 667014004262 cubane metal cluster (B-cluster) [ion binding]; other site 667014004263 Ni-Fe-S cluster (C-cluster) [ion binding]; other site 667014004264 LytTr DNA-binding domain; Region: LytTR; cl04498 667014004265 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 667014004266 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014004267 Walker A motif; other site 667014004268 ATP binding site [chemical binding]; other site 667014004269 Walker B motif; other site 667014004270 arginine finger; other site 667014004271 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 667014004272 Ku-core domain; includes the central DNA-binding beta-barrels, polypeptide rings, and the C-terminal arm of Ku proteins. The Ku protein consists of two tightly associated homologous subunits, Ku70 and Ku80, and was originally identified as an...; Region: KU; cl02666 667014004273 DNA binding site [nucleotide binding] 667014004274 heterodimer interface [polypeptide binding]; other site 667014004275 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 667014004276 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 667014004277 active site 667014004278 DNA binding site [nucleotide binding] 667014004279 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 667014004280 DNA binding site [nucleotide binding] 667014004281 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 667014004282 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 667014004283 NAD(P) binding site [chemical binding]; other site 667014004284 dimer interface [polypeptide binding]; other site 667014004285 tetramer (dimer of dimers) interface [polypeptide binding]; other site 667014004286 substrate binding site [chemical binding]; other site 667014004287 Archaea-specific editing domain of threonyl-tRNA synthetase; Region: tRNA-Thr_ED; pfam08915 667014004288 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 667014004289 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 667014004290 dimerization interface [polypeptide binding]; other site 667014004291 putative DNA binding site [nucleotide binding]; other site 667014004292 putative Zn2+ binding site [ion binding]; other site 667014004293 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is...; Region: CobU; cd00544 667014004294 homotrimer interface [polypeptide binding]; other site 667014004295 Walker A motif; other site 667014004296 GTP binding site [chemical binding]; other site 667014004297 Walker B motif; other site 667014004298 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 667014004299 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 667014004300 catalytic loop [active] 667014004301 iron binding site [ion binding]; other site 667014004302 FGGY family of carbohydrate kinases; Region: FGGY; cl08364 667014004303 catalytic site [active] 667014004304 metal binding site [ion binding]; metal-binding site 667014004305 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 667014004306 substrate binding pocket [chemical binding]; other site 667014004307 dimer interface [polypeptide binding]; other site 667014004308 inhibitor binding site; inhibition site 667014004309 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014004310 Predicted permease; Region: DUF318; cl00487 667014004311 hypothetical protein; Provisional; Region: PRK14851 667014004312 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 667014004313 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 667014004314 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014004315 hypothetical protein; Provisional; Region: PRK14852 667014004316 Creatinine amidohydrolase; Region: Creatininase; cl00618 667014004317 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing...; Region: TlpA_like_family; cd02966 667014004318 catalytic residues [active] 667014004319 selenophosphate synthetase; Provisional; Region: PRK00943 667014004320 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 667014004321 dimerization interface [polypeptide binding]; other site 667014004322 putative ATP binding site [chemical binding]; other site 667014004323 PAS fold; Region: PAS_4; pfam08448 667014004324 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 667014004325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014004326 dimer interface [polypeptide binding]; other site 667014004327 phosphorylation site [posttranslational modification] 667014004328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014004329 ATP binding site [chemical binding]; other site 667014004330 Mg2+ binding site [ion binding]; other site 667014004331 G-X-G motif; other site 667014004332 Response regulator receiver domain; Region: Response_reg; pfam00072 667014004333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014004334 active site 667014004335 phosphorylation site [posttranslational modification] 667014004336 intermolecular recognition site; other site 667014004337 dimerization interface [polypeptide binding]; other site 667014004338 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 667014004339 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG4871 667014004340 Putative Fe-S cluster; Region: FeS; pfam04060 667014004341 Domain of unknown function (DUF3786); Region: DUF3786; pfam12654 667014004342 reverse gyrase; Reviewed; Region: PRK09401 667014004343 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004344 TopoIA_RevGyr : The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to the ATP-dependent reverse gyrase found in archaea and thermophilic bacteria. Type IA DNA topoisomerases remove...; Region: TOPRIM_TopoIA_RevGyr; cd03361 667014004345 active site 667014004346 putative interdomain interaction site [polypeptide binding]; other site 667014004347 putative metal-binding site [ion binding]; other site 667014004348 putative nucleotide binding site [chemical binding]; other site 667014004349 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 667014004350 domain I; other site 667014004351 DNA binding groove [nucleotide binding] 667014004352 phosphate binding site [ion binding]; other site 667014004353 domain II; other site 667014004354 domain III; other site 667014004355 nucleotide binding site [chemical binding]; other site 667014004356 catalytic site [active] 667014004357 domain IV; other site 667014004358 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 667014004359 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014004360 active site 667014004361 phosphorylation site [posttranslational modification] 667014004362 intermolecular recognition site; other site 667014004363 dimerization interface [polypeptide binding]; other site 667014004364 ANTAR domain; Region: ANTAR; cl04297 667014004365 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014004366 glycyl-tRNA synthetase, tetrameric type, alpha subunit; Region: glyQ; TIGR00388 667014004367 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 667014004368 dimer interface [polypeptide binding]; other site 667014004369 motif 1; other site 667014004370 active site 667014004371 motif 2; other site 667014004372 motif 3; other site 667014004373 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 667014004374 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014004375 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 667014004376 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 667014004377 S17 interaction site [polypeptide binding]; other site 667014004378 S8 interaction site; other site 667014004379 16S rRNA interaction site [nucleotide binding]; other site 667014004380 streptomycin interaction site [chemical binding]; other site 667014004381 23S rRNA interaction site [nucleotide binding]; other site 667014004382 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 667014004383 Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313 667014004384 elongation factor G; Reviewed; Region: PRK00007 667014004385 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G; cd01886 667014004386 G1 box; other site 667014004387 putative GEF interaction site [polypeptide binding]; other site 667014004388 GTP/Mg2+ binding site [chemical binding]; other site 667014004389 Switch I region; other site 667014004390 G2 box; other site 667014004391 G3 box; other site 667014004392 Switch II region; other site 667014004393 G4 box; other site 667014004394 G5 box; other site 667014004395 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 667014004396 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 667014004397 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 667014004398 elongation factor Tu; Reviewed; Region: PRK00049 667014004399 EF-Tu subfamily. This subfamily includes orthologs of translation elongation factor EF-Tu in bacteria, mitochondria, and chloroplasts. It is one of several GTP-binding translation factors found in the larger family of GTP-binding elongation factors; Region: EF_Tu; cd01884 667014004400 G1 box; other site 667014004401 GEF interaction site [polypeptide binding]; other site 667014004402 GTP/Mg2+ binding site [chemical binding]; other site 667014004403 Switch I region; other site 667014004404 G2 box; other site 667014004405 G3 box; other site 667014004406 Switch II region; other site 667014004407 G4 box; other site 667014004408 G5 box; other site 667014004409 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 667014004410 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts)...; Region: EFTU_III; cd03707 667014004411 Antibiotic Binding Site [chemical binding]; other site 667014004412 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 667014004413 Ribosomal protein L3; Region: Ribosomal_L3; cl00324 667014004414 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 667014004415 Ribosomal protein L23; Region: Ribosomal_L23; cl00326 667014004416 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 667014004417 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 667014004418 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 667014004419 Ribosomal protein S19; Region: Ribosomal_S19; cl00350 667014004420 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 667014004421 putative translocon binding site; other site 667014004422 protein-rRNA interface [nucleotide binding]; other site 667014004423 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 667014004424 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The...; Region: 30S_S3_KH; cd02412 667014004425 G-X-X-G motif; other site 667014004426 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 667014004427 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 667014004428 23S rRNA interface [nucleotide binding]; other site 667014004429 5S rRNA interface [nucleotide binding]; other site 667014004430 putative antibiotic binding site [chemical binding]; other site 667014004431 L25 interface [polypeptide binding]; other site 667014004432 L27 interface [polypeptide binding]; other site 667014004433 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where...; Region: Ribosomal_L29_HIP; cd00427 667014004434 23S rRNA interface [nucleotide binding]; other site 667014004435 putative translocon interaction site; other site 667014004436 signal recognition particle (SRP54) interaction site; other site 667014004437 L23 interface [polypeptide binding]; other site 667014004438 trigger factor interaction site; other site 667014004439 Ribosomal protein S17; Region: Ribosomal_S17; cl00351 667014004440 Ribosomal protein L14p/L23e; Region: Ribosomal_L14; cl00328 667014004441 KOW motif; Region: KOW; cl00354 667014004442 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 667014004443 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 667014004444 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 667014004445 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 667014004446 Ribosomal protein S8; Region: Ribosomal_S8; cl00330 667014004447 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 667014004448 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 667014004449 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 667014004450 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 667014004451 23S rRNA interface [nucleotide binding]; other site 667014004452 5S rRNA interface [nucleotide binding]; other site 667014004453 L27 interface [polypeptide binding]; other site 667014004454 L5 interface [polypeptide binding]; other site 667014004455 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 667014004456 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 667014004457 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 667014004458 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins...; Region: Ribosomal_L30; cd01658 667014004459 23S rRNA binding site [nucleotide binding]; other site 667014004460 Ribosomal protein L18e/L15; Region: Ribosomal_L18e; cl12022 667014004461 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 667014004462 SecY translocase; Region: SecY; pfam00344 667014004463 adenylate kinase; Reviewed; Region: adk; PRK00279 667014004464 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 667014004465 AMP-binding site [chemical binding]; other site 667014004466 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 667014004467 methionine aminopeptidase; Reviewed; Region: PRK07281 667014004468 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 667014004469 active site 667014004470 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 667014004471 rRNA binding site [nucleotide binding]; other site 667014004472 predicted 30S ribosome binding site; other site 667014004473 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 667014004474 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 667014004475 Ribosomal protein S11; Region: Ribosomal_S11; cl00332 667014004476 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 667014004477 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 667014004478 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 667014004479 RNA binding surface [nucleotide binding]; other site 667014004480 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 667014004481 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 667014004482 alphaNTD - beta interaction site [polypeptide binding]; other site 667014004483 alphaNTD homodimer interface [polypeptide binding]; other site 667014004484 alphaNTD - beta' interaction site [polypeptide binding]; other site 667014004485 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; cl11613 667014004486 Ribosomal protein L17; Region: Ribosomal_L17; cl00356 667014004487 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 667014004488 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 667014004489 active site 667014004490 metal binding site [ion binding]; metal-binding site 667014004491 hexamer interface [polypeptide binding]; other site 667014004492 recombination factor protein RarA; Reviewed; Region: PRK13342 667014004493 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014004494 Walker A motif; other site 667014004495 ATP binding site [chemical binding]; other site 667014004496 Walker B motif; other site 667014004497 arginine finger; other site 667014004498 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 667014004499 Uncharacterized protein family UPF0054; Region: UPF0054; cl00402 667014004500 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in the...; Region: PNPsynthase; cd00003 667014004501 active site 667014004502 hydrophilic channel; other site 667014004503 dimerization interface [polypeptide binding]; other site 667014004504 catalytic residues [active] 667014004505 active site lid [active] 667014004506 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 667014004507 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 667014004508 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 667014004509 DNA binding site [nucleotide binding] 667014004510 Int/Topo IB signature motif; other site 667014004511 active site 667014004512 Uncharacterised protein family (UPF0175); Region: UPF0175; cl01085 667014004513 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 667014004514 Domain of unknown function (DUF3368); Region: DUF3368; pfam11848 667014004515 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 667014004516 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 667014004517 polymerase nucleotide-binding site; other site 667014004518 DNA-binding residues [nucleotide binding]; DNA binding site 667014004519 nucleotide binding site [chemical binding]; other site 667014004520 primase nucleotide-binding site [nucleotide binding]; other site 667014004521 DEAD-like helicases superfamily; Region: DEXDc; smart00487 667014004522 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 667014004523 ATP binding site [chemical binding]; other site 667014004524 putative Mg++ binding site [ion binding]; other site 667014004525 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 667014004526 nucleotide binding region [chemical binding]; other site 667014004527 Restriction endonuclease [Defense mechanisms]; Region: COG3587 667014004528 ATP-binding site [chemical binding]; other site 667014004529 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 667014004530 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014004531 Semialdehyde dehydrogenase, dimerisation domain; Region: Semialdhyde_dhC; pfam02774 667014004532 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 667014004533 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004534 Walker A/P-loop; other site 667014004535 ATP binding site [chemical binding]; other site 667014004536 Q-loop/lid; other site 667014004537 RecN ATPase involved in DNA repair; ABC (ATP-binding cassette) transporter nucleotide-binding domain; ABC transporters are a large family of proteins involved in the transport of a wide variety of different compounds including sugars, ions, peptides...; Region: ABC_RecN; cd03241 667014004538 ABC transporter signature motif; other site 667014004539 Walker B; other site 667014004540 D-loop; other site 667014004541 H-loop/switch region; other site 667014004542 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 667014004543 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 667014004544 Ligand Binding Site [chemical binding]; other site 667014004545 Domain of unknown function (DUF814); Region: DUF814; pfam05670 667014004546 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 667014004547 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 667014004548 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2,3-...; Region: LbH_LpxD; cd03352 667014004549 trimer interface [polypeptide binding]; other site 667014004550 active site 667014004551 UDP-GlcNAc binding site [chemical binding]; other site 667014004552 lipid binding site [chemical binding]; lipid-binding site 667014004553 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 667014004554 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 667014004555 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A...; Region: LbH_UDP-GlcNAc_AT; cd03351 667014004556 active site 667014004557 Protein of unknown function (DUF1009); Region: DUF1009; cl09182 667014004558 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 667014004559 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014004560 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 667014004561 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 667014004562 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 667014004563 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 667014004564 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; cl01801 667014004565 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a...; Region: GT1_AviGT4_like; cd03802 667014004566 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014004567 putative ADP-binding pocket [chemical binding]; other site 667014004568 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes...; Region: SIRT5_Af1_CobB; cd01412 667014004569 NAD+ binding site [chemical binding]; other site 667014004570 substrate binding site [chemical binding]; other site 667014004571 Zn binding site [ion binding]; other site 667014004572 Elongation factor G (EF-G) subfamily. Translocation is mediated by EF-G (also called translocase). The structure of EF-G closely resembles that of the complex between EF-Tu and tRNA. This is an example of molecular mimicry; a protein domain evolved...; Region: EF-G_bact; cd04170 667014004573 G1 box; other site 667014004574 putative GEF interaction site [polypeptide binding]; other site 667014004575 elongation factor G; Reviewed; Region: PRK12740 667014004576 GTP/Mg2+ binding site [chemical binding]; other site 667014004577 Switch I region; other site 667014004578 G2 box; other site 667014004579 G3 box; other site 667014004580 Switch II region; other site 667014004581 G4 box; other site 667014004582 G5 box; other site 667014004583 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide...; Region: EFG_mtEFG_II; cd04088 667014004584 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor...; Region: EFG_mtEFG1_IV; cd01434 667014004585 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor...; Region: EFG_mtEFG_C; cd03713 667014004586 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea...; Region: MogA_MoaB; cd00886 667014004587 MPT binding site; other site 667014004588 trimer interface [polypeptide binding]; other site 667014004589 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 667014004590 Ligand Binding Site [chemical binding]; other site 667014004591 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 667014004592 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase [Lipid metabolism]; Region: IspE; COG1947 667014004593 GHMP kinases N terminal domain; Region: GHMP_kinases_N; cl08256 667014004594 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 667014004595 Phosphoribosyl transferase domain; Region: Pribosyltran; cl00309 667014004596 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 667014004597 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 667014004598 5S rRNA interface [nucleotide binding]; other site 667014004599 CTC domain interface [polypeptide binding]; other site 667014004600 L16 interface [polypeptide binding]; other site 667014004601 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 667014004602 putative active site [active] 667014004603 catalytic residue [active] 667014004604 Macro domain, Appr-1'-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Appr_pase_like; cd02908 667014004605 putative ADP-ribose binding site [chemical binding]; other site 667014004606 putative active site [active] 667014004607 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 667014004608 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of...; Region: DnaJ; cd06257 667014004609 HSP70 interaction site [polypeptide binding]; other site 667014004610 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 667014004611 DnaJ C terminal domain; Region: DnaJ_C; pfam01556 667014004612 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 667014004613 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a single-strand-...; Region: ExoVII_LU_OBF; cd04489 667014004614 generic binding surface II; other site 667014004615 generic binding surface I; other site 667014004616 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 667014004617 Peptidase family M23; Region: Peptidase_M23; pfam01551 667014004618 Exonuclease VII small subunit; Region: Exonuc_VII_S; cl00750 667014004619 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 667014004620 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 667014004621 substrate binding pocket [chemical binding]; other site 667014004622 chain length determination region; other site 667014004623 substrate-Mg2+ binding site; other site 667014004624 catalytic residues [active] 667014004625 aspartate-rich region 1; other site 667014004626 active site lid residues [active] 667014004627 aspartate-rich region 2; other site 667014004628 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 667014004629 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 667014004630 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 667014004631 TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products with important pharmaceutical activity. DXS...; Region: TPP_DXS; cd02007 667014004632 TPP-binding site; other site 667014004633 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 667014004634 PYR/PP interface [polypeptide binding]; other site 667014004635 dimer interface [polypeptide binding]; other site 667014004636 TPP binding site [chemical binding]; other site 667014004637 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 667014004638 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 667014004639 Protein export membrane protein; Region: SecD_SecF; cl14618 667014004640 Protein of unknown function (DUF1329); Region: DUF1329; pfam07044 667014004641 Uncharacterized homolog of PrgY (pheromone shutdown protein) [Function unknown]; Region: COG1916 667014004642 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase contains two...; Region: OMP_decarboxylase_like; cd04725 667014004643 active site 667014004644 dimer interface [polypeptide binding]; other site 667014004645 Protein of unknown function (DUF763); Region: DUF763; cl00620 667014004646 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 667014004647 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 667014004648 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 667014004649 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl01295 667014004650 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 667014004651 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 667014004652 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 667014004653 catalytic triad [active] 667014004654 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 667014004655 Peptidase family M23; Region: Peptidase_M23; pfam01551 667014004656 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 667014004657 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 667014004658 FMN binding site [chemical binding]; other site 667014004659 active site 667014004660 catalytic residues [active] 667014004661 substrate binding site [chemical binding]; other site 667014004662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 667014004663 active site 667014004664 intersubunit interface [polypeptide binding]; other site 667014004665 zinc binding site [ion binding]; other site 667014004666 Na+ binding site [ion binding]; other site 667014004667 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 667014004668 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014004669 S-adenosylmethionine binding site [chemical binding]; other site 667014004670 M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659 667014004671 oligomer interface [polypeptide binding]; other site 667014004672 putative active site [active] 667014004673 metal binding site [ion binding]; metal-binding site 667014004674 Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972 667014004675 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase...; Region: crotonase-like; cl14780 667014004676 active site 667014004677 Rhomboid family; Region: Rhomboid; cl11446 667014004678 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cl11391 667014004679 GMP synthase; Reviewed; Region: guaA; PRK00074 667014004680 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 667014004681 AMP/PPi binding site [chemical binding]; other site 667014004682 candidate oxyanion hole; other site 667014004683 catalytic triad [active] 667014004684 potential glutamine specificity residues [chemical binding]; other site 667014004685 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 667014004686 ATP Binding subdomain [chemical binding]; other site 667014004687 Ligand Binding sites [chemical binding]; other site 667014004688 Dimerization subdomain; other site 667014004689 Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041 667014004690 Ferritin-like domain; Region: Ferritin; pfam00210 667014004691 binuclear metal center [ion binding]; other site 667014004692 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected...; Region: rubredoxin_like; cl00202 667014004693 iron binding site [ion binding]; other site 667014004694 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 667014004695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014004696 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 667014004697 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 667014004698 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 667014004699 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 667014004700 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 667014004701 ATP binding site [chemical binding]; other site 667014004702 putative Mg++ binding site [ion binding]; other site 667014004703 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 667014004704 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 667014004705 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 667014004706 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 667014004707 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 667014004708 active site 667014004709 catalytic triad [active] 667014004710 26S protease regulatory subunit 6B-like protein; Provisional; Region: PTZ00454 667014004711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014004712 Walker A motif; other site 667014004713 ATP binding site [chemical binding]; other site 667014004714 Walker B motif; other site 667014004715 arginine finger; other site 667014004716 Protein of unknown function (DUF1016); Region: DUF1016; cl01979 667014004717 HsdM N-terminal domain; Region: HsdM_N; pfam12161 667014004718 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 667014004719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014004720 FlaG protein; Region: FlaG; cl00591 667014004721 Response regulator receiver domain; Region: Response_reg; pfam00072 667014004722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014004723 active site 667014004724 phosphorylation site [posttranslational modification] 667014004725 intermolecular recognition site; other site 667014004726 dimerization interface [polypeptide binding]; other site 667014004727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014004728 Response regulator receiver domain; Region: Response_reg; pfam00072 667014004729 active site 667014004730 phosphorylation site [posttranslational modification] 667014004731 intermolecular recognition site; other site 667014004732 dimerization interface [polypeptide binding]; other site 667014004733 GAF domain; Region: GAF; cl00853 667014004734 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 667014004735 Zn2+ binding site [ion binding]; other site 667014004736 Mg2+ binding site [ion binding]; other site 667014004737 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 667014004738 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 667014004739 DNA recombination-mediator protein A; Region: DNA_processg_A; cl00695 667014004740 DNA topoisomerase I; Validated; Region: PRK06599 667014004741 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in...; Region: TOPRIM_TopoIA_TopoI; cd03363 667014004742 active site 667014004743 interdomain interaction site; other site 667014004744 putative metal-binding site [ion binding]; other site 667014004745 nucleotide binding site [chemical binding]; other site 667014004746 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded...; Region: TOP1Ac; cd00186 667014004747 domain I; other site 667014004748 DNA binding groove [nucleotide binding] 667014004749 phosphate binding site [ion binding]; other site 667014004750 domain II; other site 667014004751 domain III; other site 667014004752 nucleotide binding site [chemical binding]; other site 667014004753 catalytic site [active] 667014004754 domain IV; other site 667014004755 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 667014004756 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 667014004757 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; cl11977 667014004758 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 667014004759 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 667014004760 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 667014004761 ResB-like family; Region: ResB; pfam05140 667014004762 Uncharacterised protein family (UPF0150); Region: UPF0150; cl00691 667014004763 YcfA-like protein; Region: YcfA; cl00752 667014004764 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 667014004765 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase...; Region: TGS_ThrRS_N; cd01667 667014004766 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 667014004767 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 667014004768 active site 667014004769 dimer interface [polypeptide binding]; other site 667014004770 motif 1; other site 667014004771 motif 2; other site 667014004772 motif 3; other site 667014004773 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 667014004774 anticodon binding site; other site 667014004775 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 667014004776 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 667014004777 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 667014004778 Ribosomal protein L35; Region: Ribosomal_L35p; cl00392 667014004779 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 667014004780 23S rRNA binding site [nucleotide binding]; other site 667014004781 L21 binding site [polypeptide binding]; other site 667014004782 L13 binding site [polypeptide binding]; other site 667014004783 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 667014004784 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 667014004785 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 667014004786 dimer interface [polypeptide binding]; other site 667014004787 motif 1; other site 667014004788 active site 667014004789 motif 2; other site 667014004790 motif 3; other site 667014004791 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 667014004792 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 667014004793 putative tRNA-binding site [nucleotide binding]; other site 667014004794 B3/4 domain; Region: B3_4; cl11458 667014004795 tRNA synthetase B5 domain; Region: B5; cl08394 667014004796 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 667014004797 dimer interface [polypeptide binding]; other site 667014004798 motif 1; other site 667014004799 motif 3; other site 667014004800 motif 2; other site 667014004801 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; cl08386 667014004802 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 667014004803 IHF - DNA interface [nucleotide binding]; other site 667014004804 IHF dimer interface [polypeptide binding]; other site 667014004805 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 667014004806 DNA binding residues [nucleotide binding] 667014004807 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 667014004808 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014004809 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 667014004810 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 667014004811 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 667014004812 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014004813 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule...; Region: GT1_like_2; cd03814 667014004814 Predicted deacetylase [General function prediction only]; Region: COG3233 667014004815 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 667014004816 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 667014004817 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 667014004818 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014004819 motif II; other site 667014004820 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 667014004821 S-adenosylmethionine synthetase; Validated; Region: PRK05250 667014004822 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 667014004823 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 667014004824 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 667014004825 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 667014004826 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 667014004827 DNA topoisomerase I; Validated; Region: PRK06599 667014004828 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 667014004829 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 667014004830 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014004831 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014004832 aconitate hydratase; Validated; Region: PRK07229 667014004833 Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: AcnA_Bact; cd01585 667014004834 substrate binding site [chemical binding]; other site 667014004835 ligand binding site [chemical binding]; other site 667014004836 Bacterial Aconitase-like swivel domain. Aconitase (aconitate hydratase or citrate hydrolyase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. Cis-aconitate is formed as an intermediate product during the...; Region: AcnA_Bact_Swivel; cd01579 667014004837 substrate binding site [chemical binding]; other site 667014004838 Uncharacterised protein family (UPF0182); Region: UPF0182; pfam03699 667014004839 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 667014004840 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 667014004841 transcriptional regulator PpsR; Region: PpsR-CrtJ; TIGR02040 667014004842 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 667014004843 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 667014004844 putative active site [active] 667014004845 heme pocket [chemical binding]; other site 667014004846 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014004847 dimer interface [polypeptide binding]; other site 667014004848 phosphorylation site [posttranslational modification] 667014004849 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014004850 ATP binding site [chemical binding]; other site 667014004851 Mg2+ binding site [ion binding]; other site 667014004852 G-X-G motif; other site 667014004853 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014004854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014004855 active site 667014004856 phosphorylation site [posttranslational modification] 667014004857 intermolecular recognition site; other site 667014004858 dimerization interface [polypeptide binding]; other site 667014004859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014004860 Walker A motif; other site 667014004861 ATP binding site [chemical binding]; other site 667014004862 Walker B motif; other site 667014004863 arginine finger; other site 667014004864 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014004865 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 667014004866 thiosulfate reductase PhsA; Provisional; Region: PRK15488 667014004867 The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755 667014004868 putative [Fe4-S4] binding site [ion binding]; other site 667014004869 putative molybdopterin cofactor binding site [chemical binding]; other site 667014004870 The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound...; Region: MopB_CT_Thiosulfate-R-like; cd02778 667014004871 putative molybdopterin cofactor binding site; other site 667014004872 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 667014004873 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 667014004874 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 667014004875 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 667014004876 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 667014004877 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl00539 667014004878 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 667014004879 NADH dehydrogenase; Region: NADHdh; cl00469 667014004880 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 667014004881 4Fe-4S binding domain; Region: Fer4; cl02805 667014004882 NADH dehydrogenase subunit J; Provisional; Region: PRK06433; cl14634 667014004883 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 667014004884 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L; Region: Oxidored_q2; cl00492 667014004885 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 667014004886 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 667014004887 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 667014004888 NADH-Ubiquinone oxidoreductase (complex I) subunit C-terminus; Region: Oxidored_q1_C; pfam01010 667014004889 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 667014004890 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 667014004891 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 667014004892 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; cl14187 667014004893 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 667014004894 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 667014004895 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 667014004896 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 667014004897 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 667014004898 catalytic residue [active] 667014004899 Protein of unknown function DUF72; Region: DUF72; cl00777 667014004900 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but...; Region: Dtyr_deacylase; cd00563 667014004901 putative active site [active] 667014004902 dimerization interface [polypeptide binding]; other site 667014004903 putative tRNAtyr binding site [nucleotide binding]; other site 667014004904 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014004905 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole...; Region: Ribosomal_S15p_S13e; cd00353 667014004906 16S/18S rRNA binding site [nucleotide binding]; other site 667014004907 S13e-L30e interaction site [polypeptide binding]; other site 667014004908 25S rRNA binding site [nucleotide binding]; other site 667014004909 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 667014004910 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 667014004911 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 667014004912 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 667014004913 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 667014004914 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA...; Region: S1_PNPase; cd04472 667014004915 RNA binding site [nucleotide binding]; other site 667014004916 domain interface; other site 667014004917 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 667014004918 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 667014004919 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 667014004920 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004921 Walker A/P-loop; other site 667014004922 ATP binding site [chemical binding]; other site 667014004923 Q-loop/lid; other site 667014004924 ABC transporter signature motif; other site 667014004925 Walker B; other site 667014004926 D-loop; other site 667014004927 H-loop/switch region; other site 667014004928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014004929 dimer interface [polypeptide binding]; other site 667014004930 conserved gate region; other site 667014004931 putative PBP binding loops; other site 667014004932 ABC-ATPase subunit interface; other site 667014004933 Transposase domain (DUF772); Region: DUF772; cl12084 667014004934 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 667014004935 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014004936 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014004937 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014004938 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 667014004939 Walker A/P-loop; other site 667014004940 ATP binding site [chemical binding]; other site 667014004941 Q-loop/lid; other site 667014004942 ABC transporter signature motif; other site 667014004943 Walker B; other site 667014004944 D-loop; other site 667014004945 H-loop/switch region; other site 667014004946 ABC-2 type transporter; Region: ABC2_membrane; cl11417 667014004947 Predicted transcriptional regulators [Transcription]; Region: COG1318 667014004948 probable regulatory domain; Region: near_KaiC_dom; TIGR03879 667014004949 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014004950 aminodeoxychorismate synthase; Provisional; Region: PRK07508 667014004951 chorismate binding enzyme; Region: Chorismate_bind; cl10555 667014004952 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and 4-amino-4-deoxychorismate...; Region: PLPDE_IV; cl00224 667014004953 Aminotransferase class IV; Region: Aminotran_4; pfam01063 667014004954 substrate-cofactor binding pocket; other site 667014004955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014004956 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 667014004957 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 667014004958 Walker A/P-loop; other site 667014004959 ATP binding site [chemical binding]; other site 667014004960 Q-loop/lid; other site 667014004961 ABC transporter signature motif; other site 667014004962 Walker B; other site 667014004963 D-loop; other site 667014004964 H-loop/switch region; other site 667014004965 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 667014004966 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 667014004967 The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane...; Region: ABC_NikE_OppD_transporters; cd03257 667014004968 Walker A/P-loop; other site 667014004969 ATP binding site [chemical binding]; other site 667014004970 Q-loop/lid; other site 667014004971 ABC transporter signature motif; other site 667014004972 Walker B; other site 667014004973 D-loop; other site 667014004974 H-loop/switch region; other site 667014004975 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 667014004976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014004977 dimer interface [polypeptide binding]; other site 667014004978 conserved gate region; other site 667014004979 putative PBP binding loops; other site 667014004980 ABC-ATPase subunit interface; other site 667014004981 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 667014004982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014004983 dimer interface [polypeptide binding]; other site 667014004984 conserved gate region; other site 667014004985 putative PBP binding loops; other site 667014004986 ABC-ATPase subunit interface; other site 667014004987 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 667014004988 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 667014004989 putative PEP-CTERM system histidine kinase; Region: PEP_his_kin; TIGR02916 667014004990 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014004991 ATP binding site [chemical binding]; other site 667014004992 Mg2+ binding site [ion binding]; other site 667014004993 G-X-G motif; other site 667014004994 Response regulator receiver domain; Region: Response_reg; pfam00072 667014004995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014004996 active site 667014004997 phosphorylation site [posttranslational modification] 667014004998 intermolecular recognition site; other site 667014004999 dimerization interface [polypeptide binding]; other site 667014005000 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 667014005001 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014005002 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 667014005003 Uncharacterized conserved protein [Function unknown]; Region: COG1751 667014005004 Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887 667014005005 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 667014005006 Zn2+ binding site [ion binding]; other site 667014005007 Mg2+ binding site [ion binding]; other site 667014005008 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 667014005009 Zn2+ binding site [ion binding]; other site 667014005010 Mg2+ binding site [ion binding]; other site 667014005011 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 667014005012 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 667014005013 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate...; Region: APP_MetAP; cl00279 667014005014 active site 667014005015 lytic murein transglycosylase; Region: MltB_2; TIGR02283 667014005016 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic 'goose-type' lysozymes (GEWL). LTs catalyze...; Region: LT_GEWL; cd00254 667014005017 N-acetyl-D-glucosamine binding site [chemical binding]; other site 667014005018 catalytic residue [active] 667014005019 Response regulator receiver domain; Region: Response_reg; pfam00072 667014005020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014005021 active site 667014005022 phosphorylation site [posttranslational modification] 667014005023 intermolecular recognition site; other site 667014005024 dimerization interface [polypeptide binding]; other site 667014005025 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically 'activated' sulfate form important for the assimilation...; Region: APSK; cd02027 667014005026 ligand-binding site [chemical binding]; other site 667014005027 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 667014005028 putative homodimer interface [polypeptide binding]; other site 667014005029 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 667014005030 Peptidase family M23; Region: Peptidase_M23; pfam01551 667014005031 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 667014005032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014005033 S-adenosylmethionine binding site [chemical binding]; other site 667014005034 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 667014005035 Peptidase family M48; Region: Peptidase_M48; cl12018 667014005036 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014005037 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 667014005038 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 667014005039 Sugar fermentation stimulation protein; Region: SfsA; cl00647 667014005040 TIGR03790 family protein; Region: TIGR03790 667014005041 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014005042 binding surface 667014005043 TPR motif; other site 667014005044 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014005045 binding surface 667014005046 TPR motif; other site 667014005047 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 667014005048 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 667014005049 NAD binding site [chemical binding]; other site 667014005050 homodimer interface [polypeptide binding]; other site 667014005051 active site 667014005052 substrate binding site [chemical binding]; other site 667014005053 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 667014005054 dimer interface [polypeptide binding]; other site 667014005055 active site 667014005056 Schiff base residues; other site 667014005057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 667014005058 putative substrate translocation pore; other site 667014005059 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 667014005060 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 667014005061 dimer interface [polypeptide binding]; other site 667014005062 ssDNA binding site [nucleotide binding]; other site 667014005063 tetramer (dimer of dimers) interface [polypeptide binding]; other site 667014005064 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 667014005065 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 667014005066 Walker A/P-loop; other site 667014005067 ATP binding site [chemical binding]; other site 667014005068 Barmotin is a tight junction-associated protein expressed in rat epithelial cells which is thought to have an important regulatory role in tight junction barrier function. Barmotin belongs to the SMC protein family. SMC proteins are large (...; Region: ABC_SMC_barmotin; cd03278 667014005069 ABC transporter signature motif; other site 667014005070 Walker B; other site 667014005071 D-loop; other site 667014005072 H-loop/switch region; other site 667014005073 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 667014005074 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 667014005075 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 667014005076 Ribosomal protein S18; Region: Ribosomal_S18; cl00373 667014005077 Ribosomal protein S6; Region: Ribosomal_S6; cl00414 667014005078 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A Ham1-...; Region: HAM1; cd00515 667014005079 active site 667014005080 dimerization interface [polypeptide binding]; other site 667014005081 ribonuclease PH; Reviewed; Region: rph; PRK00173 667014005082 3' exoribonuclease family, domain 1; Region: RNase_PH; pfam01138 667014005083 3' exoribonuclease family, domain 2; Region: RNase_PH_C; pfam03725 667014005084 Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348 667014005085 4Fe-4S binding domain; Region: Fer4_5; pfam12801 667014005086 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014005087 Domain of unknown function DUF77; Region: DUF77; cl00307 667014005088 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Region: NadD; COG1057 667014005089 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 667014005090 active site 667014005091 (T/H)XGH motif; other site 667014005092 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 667014005093 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 667014005094 putative catalytic cysteine [active] 667014005095 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 667014005096 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 667014005097 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005098 DEAD-like helicases superfamily; Region: DEXDc; smart00487 667014005099 ATP binding site [chemical binding]; other site 667014005100 putative Mg++ binding site [ion binding]; other site 667014005101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 667014005102 nucleotide binding region [chemical binding]; other site 667014005103 ATP-binding site [chemical binding]; other site 667014005104 CheD chemotactic sensory transduction; Region: CheD; cl00810 667014005105 Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639 667014005106 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 667014005107 Zn2+ binding site [ion binding]; other site 667014005108 Mg2+ binding site [ion binding]; other site 667014005109 Flagellar biosynthesis pathway, component FlhB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhB; cl12017 667014005110 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 667014005111 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 667014005112 homodimer interface [polypeptide binding]; other site 667014005113 oligonucleotide binding site [chemical binding]; other site 667014005114 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 667014005115 MoaE homodimer interface [polypeptide binding]; other site 667014005116 MoaD interaction [polypeptide binding]; other site 667014005117 active site residues [active] 667014005118 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014005119 binding surface 667014005120 TPR motif; other site 667014005121 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cl02429 667014005122 binding surface 667014005123 TPR motif; other site 667014005124 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 667014005125 heme-binding residues [chemical binding]; other site 667014005126 NodT family; Region: outer_NodT; TIGR01845 667014005127 Outer membrane efflux protein; Region: OEP; pfam02321 667014005128 Outer membrane efflux protein; Region: OEP; pfam02321 667014005129 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 667014005130 putative membrane fusion protein; Region: TIGR02828 667014005131 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 667014005132 Protein export membrane protein; Region: SecD_SecF; cl14618 667014005133 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005134 Walker A/P-loop; other site 667014005135 ATP binding site [chemical binding]; other site 667014005136 Q-loop/lid; other site 667014005137 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 667014005138 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005139 ABC transporter signature motif; other site 667014005140 Walker B; other site 667014005141 D-loop; other site 667014005142 H-loop/switch region; other site 667014005143 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 667014005144 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005145 Walker A/P-loop; other site 667014005146 ATP binding site [chemical binding]; other site 667014005147 Q-loop/lid; other site 667014005148 ABC transporter signature motif; other site 667014005149 Walker B; other site 667014005150 D-loop; other site 667014005151 H-loop/switch region; other site 667014005152 membrane glycoprotein; Provisional; Region: PHA03332 667014005153 coproporphyrinogen III oxidase; Provisional; Region: PRK05799 667014005154 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014005155 HemN C-terminal region; Region: HemN_C; pfam06969 667014005156 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 667014005157 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 667014005158 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 667014005159 Zn2+ binding site [ion binding]; other site 667014005160 Mg2+ binding site [ion binding]; other site 667014005161 DNA polymerase I; Provisional; Region: PRK05755 667014005162 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 667014005163 active site 667014005164 metal binding site 1 [ion binding]; metal-binding site 667014005165 putative 5' ssDNA interaction site; other site 667014005166 metal binding site 3; metal-binding site 667014005167 metal binding site 2 [ion binding]; metal-binding site 667014005168 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 667014005169 putative DNA binding site [nucleotide binding]; other site 667014005170 putative metal binding site [ion binding]; other site 667014005171 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 667014005172 active site 667014005173 catalytic site [active] 667014005174 substrate binding site [chemical binding]; other site 667014005175 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 667014005176 active site 667014005177 DNA binding site [nucleotide binding] 667014005178 catalytic site [active] 667014005179 PilZ domain; Region: PilZ; cl01260 667014005180 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 667014005181 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 667014005182 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 667014005183 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 667014005184 dimer interface [polypeptide binding]; other site 667014005185 active site 667014005186 CoA binding pocket [chemical binding]; other site 667014005187 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl00390 667014005188 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 667014005189 Uncharacterized ACR, COG1399; Region: DUF177; cl00616 667014005190 Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067 667014005191 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl09488 667014005192 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cd00591 667014005193 IHF dimer interface [polypeptide binding]; other site 667014005194 IHF - DNA interface [nucleotide binding]; other site 667014005195 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 667014005196 Zn binding site [ion binding]; other site 667014005197 Protein of unknown function, DUF399; Region: DUF399; cl01139 667014005198 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind C-...; Region: PDZ_serine_protease; cd00987 667014005199 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005200 hypothetical protein; Provisional; Region: PRK10557 667014005201 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 667014005202 active site 667014005203 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 667014005204 UbiA prenyltransferase family; Region: UbiA; cl00337 667014005205 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; cl00973 667014005206 Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820 667014005207 Protein of unknown function (DUF1703); Region: DUF1703; pfam08011 667014005208 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT; cl01961 667014005209 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 667014005210 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 667014005211 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 667014005212 O-Antigen ligase; Region: Wzy_C; cl04850 667014005213 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_3; cd10448 667014005214 GIY-YIG motif/motif A; other site 667014005215 putative active site [active] 667014005216 putative metal binding site [ion binding]; other site 667014005217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 667014005218 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014005219 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014005220 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 667014005221 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 667014005222 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 667014005223 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 667014005224 active site 667014005225 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 667014005226 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 667014005227 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005228 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; cl11611 667014005229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005230 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 667014005231 NAD(P) binding site [chemical binding]; other site 667014005232 active site 667014005233 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 667014005234 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 667014005235 active site 667014005236 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 667014005237 Protein of unknown function (DUF2283); Region: DUF2283; cl02251 667014005238 Plasmid stabilisation system protein; Region: Plasmid_stabil; cl11422 667014005239 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 667014005240 dimer interface [polypeptide binding]; other site 667014005241 active site 667014005242 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 667014005243 YibE/F-like protein; Region: YibE_F; cl02259 667014005244 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 667014005245 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014005246 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014005247 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 667014005248 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 667014005249 active site 667014005250 NTP binding site [chemical binding]; other site 667014005251 metal binding triad [ion binding]; metal-binding site 667014005252 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 667014005253 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014005254 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 667014005255 Phosphoenolpyruvate carboxylase [Carbohydrate transport and metabolism; Energy production and conversion]; Region: COG1892; cl14656 667014005256 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 667014005257 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 667014005258 Cl- selectivity filter; other site 667014005259 Cl- binding residues [ion binding]; other site 667014005260 pore gating glutamate residue; other site 667014005261 dimer interface [polypeptide binding]; other site 667014005262 FOG: CBS domain [General function prediction only]; Region: COG0517 667014005263 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 667014005264 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 667014005265 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 667014005266 Cl- selectivity filter; other site 667014005267 Cl- binding residues [ion binding]; other site 667014005268 pore gating glutamate residue; other site 667014005269 dimer interface [polypeptide binding]; other site 667014005270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC...; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613 667014005271 FOG: CBS domain [General function prediction only]; Region: COG0517 667014005272 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 667014005273 PhoH-like protein; Region: PhoH; cl12134 667014005274 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 667014005275 putative MPT binding site; other site 667014005276 YGGT family; Region: YGGT; cl00508 667014005277 DivIVA protein; Region: DivIVA; pfam05103 667014005278 DivIVA domain; Region: DivI1A_domain; TIGR03544 667014005279 Uncharacterised ACR, YggU family COG1872; Region: DUF167; cl00811 667014005280 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 667014005281 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014005282 motif II; other site 667014005283 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 667014005284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014005285 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 667014005286 4Fe-4S binding domain; Region: Fer4; cl02805 667014005287 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422 667014005288 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 667014005289 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014005290 4Fe-4S binding domain; Region: Fer4; cl02805 667014005291 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014005292 CoB--CoM heterodisulfide reductase, subunit C; Region: CoB_CoM_SS_C; TIGR03290 667014005293 Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048 667014005294 Cysteine-rich domain; Region: CCG; pfam02754 667014005295 Cysteine-rich domain; Region: CCG; pfam02754 667014005296 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 667014005297 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; cl00419 667014005298 Respiratory-chain NADH dehydrogenase, 49 Kd subunit; Region: Complex1_49kDa; cl00417 667014005299 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cd00518 667014005300 nickel binding site [ion binding]; other site 667014005301 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 667014005302 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 667014005303 NHL repeat; Region: NHL; pfam01436 667014005304 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 667014005305 peptidylprolyl isomerase; Reviewed; Region: prsA; PRK03002 667014005306 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 667014005307 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005308 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005309 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005310 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005311 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014005312 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005313 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005314 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005315 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005316 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005317 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014005318 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005319 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005320 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005321 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014005322 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005323 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005324 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014005325 Uncharacterized conserved protein [Function unknown]; Region: COG3391 667014005326 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014005327 Doubled CXXCH motif (Paired_CXXCH_1); Region: Paired_CXXCH_1; cl09905 667014005328 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 667014005329 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005330 Ribulose 1,5-bisphosphate synthetase, converts PRPP to RuBP, flavoprotein [Carbohydrate transport and metabolism]; Region: THI4; COG1635 667014005331 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 667014005332 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with 5-...; Region: QPRTase; cd01572 667014005333 dimerization interface [polypeptide binding]; other site 667014005334 active site 667014005335 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014005336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014005337 active site 667014005338 phosphorylation site [posttranslational modification] 667014005339 intermolecular recognition site; other site 667014005340 dimerization interface [polypeptide binding]; other site 667014005341 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014005342 Walker A motif; other site 667014005343 ATP binding site [chemical binding]; other site 667014005344 Walker B motif; other site 667014005345 arginine finger; other site 667014005346 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014005347 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014005348 binding surface 667014005349 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 667014005350 TPR motif; other site 667014005351 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014005352 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014005353 active site 667014005354 phosphorylation site [posttranslational modification] 667014005355 intermolecular recognition site; other site 667014005356 dimerization interface [polypeptide binding]; other site 667014005357 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014005358 Walker A motif; other site 667014005359 ATP binding site [chemical binding]; other site 667014005360 Walker B motif; other site 667014005361 arginine finger; other site 667014005362 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014005363 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 667014005364 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 667014005365 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 667014005366 Flagella basal body rod protein; Region: Flg_bb_rod; cl15245 667014005367 Domain of unknown function (DUF1078); Region: DUF1078; pfam06429 667014005368 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 667014005369 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 667014005370 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 667014005371 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 667014005372 MgtE intracellular N domain; Region: MgtE_N; cl15244 667014005373 FliG C-terminal domain; Region: FliG_C; pfam01706 667014005374 type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499 667014005375 Flagellar assembly protein FliH; Region: FliH; pfam02108 667014005376 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 667014005377 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; cl15275 667014005378 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 667014005379 Walker A motif/ATP binding site; other site 667014005380 Walker B motif; other site 667014005381 MgtE intracellular N domain; Region: MgtE_N; cl15244 667014005382 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014005383 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein; Provisional; Region: PRK14494 667014005384 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria...; Region: Cytochrome_b_N; cl00859 667014005385 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 667014005386 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 667014005387 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 667014005388 [4Fe-4S] binding site [ion binding]; other site 667014005389 molybdopterin cofactor binding site; other site 667014005390 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and tungsten-...; Region: Molybdopterin-Binding; cl09928 667014005391 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 667014005392 molybdopterin cofactor binding site; other site 667014005393 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 667014005394 hypothetical protein; Provisional; Region: PRK13795 667014005395 ferredoxin; Validated; Region: PRK07118 667014005396 Formate hydrogenlyase subunit 6/NADH:ubiquinone oxidoreductase 23 kD subunit (chain I) [Energy production and conversion]; Region: NuoI; COG1143 667014005397 4Fe-4S binding domain; Region: Fer4; cl02805 667014005398 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 667014005399 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 667014005400 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 667014005401 Cation efflux family; Region: Cation_efflux; cl00316 667014005402 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 667014005403 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 667014005404 HIGH motif; other site 667014005405 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 667014005406 active site 667014005407 KMSKS motif; other site 667014005408 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 667014005409 tRNA binding surface [nucleotide binding]; other site 667014005410 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 667014005411 isocitrate dehydrogenase; Validated; Region: PRK07362 667014005412 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 667014005413 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014005414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014005415 active site 667014005416 phosphorylation site [posttranslational modification] 667014005417 intermolecular recognition site; other site 667014005418 dimerization interface [polypeptide binding]; other site 667014005419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014005420 Walker A motif; other site 667014005421 ATP binding site [chemical binding]; other site 667014005422 Walker B motif; other site 667014005423 arginine finger; other site 667014005424 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014005425 sensory histidine kinase AtoS; Provisional; Region: PRK11360 667014005426 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014005427 dimer interface [polypeptide binding]; other site 667014005428 phosphorylation site [posttranslational modification] 667014005429 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014005430 ATP binding site [chemical binding]; other site 667014005431 G-X-G motif; other site 667014005432 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 667014005433 Uncharacterised P-loop hydrolase UPF0079; Region: UPF0079; cl00520 667014005434 putative carbohydrate kinase; Provisional; Region: PRK10565 667014005435 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 667014005436 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 667014005437 putative substrate binding site [chemical binding]; other site 667014005438 putative ATP binding site [chemical binding]; other site 667014005439 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 667014005440 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 667014005441 Ligand Binding Site [chemical binding]; other site 667014005442 B3/4 domain; Region: B3_4; cl11458 667014005443 CobD/Cbib protein; Region: CobD_Cbib; cl00561 667014005444 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 667014005445 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 667014005446 putative dimer interface [polypeptide binding]; other site 667014005447 active site pocket [active] 667014005448 putative cataytic base [active] 667014005449 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 667014005450 Peptidase family M54; Region: Peptidase_M54; cl00835 667014005451 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 667014005452 Flavin Reductases; Region: FlaRed; cl00801 667014005453 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 667014005454 Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB2; cd01048 667014005455 diiron binding motif [ion binding]; other site 667014005456 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, 2-...; Region: ribokinase_pfkB_like; cl00192 667014005457 ATP binding site [chemical binding]; other site 667014005458 substrate binding site [chemical binding]; other site 667014005459 ketol-acid reductoisomerase; Provisional; Region: PRK05479 667014005460 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005461 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 667014005462 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 667014005463 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014005464 S-adenosylmethionine binding site [chemical binding]; other site 667014005465 CarD-like/TRCF domain; Region: CarD_TRCF; cl00588 667014005466 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 667014005467 putative active site [active] 667014005468 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 667014005469 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 667014005470 dimer interface [polypeptide binding]; other site 667014005471 putative functional site; other site 667014005472 putative MPT binding site; other site 667014005473 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 667014005474 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 667014005475 substrate binding site [chemical binding]; other site 667014005476 ligand binding site [chemical binding]; other site 667014005477 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate 3-...; Region: IPMI_Swivel; cd01577 667014005478 substrate binding site [chemical binding]; other site 667014005479 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 667014005480 TM-ABC transporter signature motif; other site 667014005481 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 667014005482 TM-ABC transporter signature motif; other site 667014005483 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 667014005484 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 667014005485 Walker A/P-loop; other site 667014005486 ATP binding site [chemical binding]; other site 667014005487 Q-loop/lid; other site 667014005488 ABC transporter signature motif; other site 667014005489 Walker B; other site 667014005490 D-loop; other site 667014005491 H-loop/switch region; other site 667014005492 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 667014005493 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 667014005494 Walker A/P-loop; other site 667014005495 ATP binding site [chemical binding]; other site 667014005496 Q-loop/lid; other site 667014005497 ABC transporter signature motif; other site 667014005498 Walker B; other site 667014005499 D-loop; other site 667014005500 H-loop/switch region; other site 667014005501 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 667014005502 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 667014005503 ligand binding site [chemical binding]; other site 667014005504 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 667014005505 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 667014005506 ligand binding site [chemical binding]; other site 667014005507 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 667014005508 Found in ATP-dependent protease La (LON); Region: LON; smart00464 667014005509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014005510 Walker A motif; other site 667014005511 ATP binding site [chemical binding]; other site 667014005512 Walker B motif; other site 667014005513 arginine finger; other site 667014005514 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 667014005515 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 667014005516 ABC-ATPase subunit interface; other site 667014005517 dimer interface [polypeptide binding]; other site 667014005518 putative PBP binding regions; other site 667014005519 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 667014005520 ABC component of the metal-type transporters. This family includes transporters involved in the uptake of various metallic cations such as iron, manganese, and zinc. The ATPases of this group of transporters are very similar to members of iron-...; Region: ABC_Metallic_Cations; cd03235 667014005521 Yip1 domain; Region: Yip1; cl12048 667014005522 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 667014005523 active site 667014005524 8-oxo-dGMP binding site [chemical binding]; other site 667014005525 nudix motif; other site 667014005526 metal binding site [ion binding]; metal-binding site 667014005527 adenylosuccinate lyase; Provisional; Region: PRK07492 667014005528 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 667014005529 tetramer interface [polypeptide binding]; other site 667014005530 active site 667014005531 SpoU rRNA Methylase family; Region: SpoU_methylase; cl00362 667014005532 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 667014005533 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 667014005534 RNA binding surface [nucleotide binding]; other site 667014005535 PseudoU_synth_RsuA/RluD: Pseudouridine synthase, RsuA/RluD family. This group is comprised of eukaryotic, bacterial and archeal proteins similar to eight site specific Escherichia coli pseudouridine synthases: RsuA, RluA, RluB, RluC, RluD, RluE, RluF...; Region: PseudoU_synth_RluCD_like; cd02869 667014005536 active site 667014005537 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 667014005538 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cl00315 667014005539 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 667014005540 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 667014005541 CoA-binding site [chemical binding]; other site 667014005542 ATP-binding [chemical binding]; other site 667014005543 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 667014005544 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 667014005545 dimer interface [polypeptide binding]; other site 667014005546 putative functional site; other site 667014005547 putative MPT binding site; other site 667014005548 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 667014005549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 667014005550 non-specific DNA binding site [nucleotide binding]; other site 667014005551 salt bridge; other site 667014005552 sequence-specific DNA binding site [nucleotide binding]; other site 667014005553 Cupin domain; Region: Cupin_2; cl09118 667014005554 S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687 667014005555 Arginase family; Region: Arginase; cl00306 667014005556 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 667014005557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014005558 dimer interface [polypeptide binding]; other site 667014005559 phosphorylation site [posttranslational modification] 667014005560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014005561 ATP binding site [chemical binding]; other site 667014005562 Mg2+ binding site [ion binding]; other site 667014005563 G-X-G motif; other site 667014005564 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 667014005565 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; cl00336 667014005566 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 667014005567 dimerization interface [polypeptide binding]; other site 667014005568 active site 667014005569 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 667014005570 homopentamer interface [polypeptide binding]; other site 667014005571 active site 667014005572 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 667014005573 putative RNA binding site [nucleotide binding]; other site 667014005574 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi...; Region: TPR; cd00189 667014005575 binding surface 667014005576 TPR motif; other site 667014005577 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 667014005578 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 667014005579 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005580 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 667014005581 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 667014005582 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 667014005583 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 667014005584 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 667014005585 GSPII_E N-terminal domain; Region: GSPII_E_N; pfam05157 667014005586 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005587 Walker A motif; other site 667014005588 ATP binding site [chemical binding]; other site 667014005589 Walker B motif; other site 667014005590 adenine deaminase; Region: ade; TIGR01178 667014005591 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 667014005592 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen...; Region: AdeC; cd01295 667014005593 active site 667014005594 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have...; Region: metallo-dependent_hydrolases; cl00281 667014005595 Sulfate transporter family; Region: Sulfate_transp; cl00967 667014005596 Permease family; Region: Xan_ur_permease; pfam00860 667014005597 Fructose-1,6-bisphosphatase; Region: FBPase_3; cl00862 667014005598 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 667014005599 chromosome segregation protein; Provisional; Region: PRK01156 667014005600 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 667014005601 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 667014005602 active site 667014005603 metal binding site [ion binding]; metal-binding site 667014005604 DNA binding site [nucleotide binding] 667014005605 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 667014005606 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 667014005607 catalytic triad [active] 667014005608 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 667014005609 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 667014005610 Cobalamin synthesis G C-terminus; Region: CbiG_C; cl12133 667014005611 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 667014005612 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 667014005613 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 667014005614 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 667014005615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014005616 S-adenosylmethionine binding site [chemical binding]; other site 667014005617 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist...; Region: TM_ABC_iron-siderophores_like; cd06550 667014005618 dimer interface [polypeptide binding]; other site 667014005619 putative PBP binding regions; other site 667014005620 ABC-ATPase subunit interface; other site 667014005621 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 667014005622 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005623 Walker A/P-loop; other site 667014005624 ATP binding site [chemical binding]; other site 667014005625 Q-loop/lid; other site 667014005626 ABC transporter signature motif; other site 667014005627 Walker B; other site 667014005628 D-loop; other site 667014005629 H-loop/switch region; other site 667014005630 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface...; Region: TroA-like; cl00262 667014005631 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 667014005632 intersubunit interface [polypeptide binding]; other site 667014005633 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 667014005634 Cobalt chelatase (CbiK); Region: CbiK; pfam06180 667014005635 active site 667014005636 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and...; Region: Chelatase_Class_II; cl02784 667014005637 active site 667014005638 Tetrapyrrole (Corrin/Porphyrin) Methylases; Region: TP_methylase; cl00304 667014005639 CbiD; Region: CbiD; cl00828 667014005640 Precorrin isomerase [Coenzyme metabolism]; Region: CobH; cl00913 667014005641 Precorrin-8X methylmutase; Region: CbiC; pfam02570 667014005642 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 667014005643 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 667014005644 MarC family integral membrane protein; Region: MarC; cl00919 667014005645 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 667014005646 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 667014005647 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 667014005648 hypothetical protein; Reviewed; Region: PRK00024 667014005649 helix-hairpin-helix signature motif; other site 667014005650 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 667014005651 MPN+ (JAMM) motif; other site 667014005652 Zinc-binding site [ion binding]; other site 667014005653 (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216 667014005654 LytB protein; Region: LYTB; cl00507 667014005655 UbiA prenyltransferase family; Region: UbiA; cl00337 667014005656 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 667014005657 nucleoside/Zn binding site; other site 667014005658 dimer interface [polypeptide binding]; other site 667014005659 catalytic motif [active] 667014005660 Pyruvate-formate lyase-activating enzyme [Posttranslational modification, protein turnover, chaperones]; Region: PflA; COG1180 667014005661 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014005662 FeS/SAM binding site; other site 667014005663 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 667014005664 dimerization interface [polypeptide binding]; other site 667014005665 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 667014005666 ATP binding site [chemical binding]; other site 667014005667 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 667014005668 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 667014005669 active site 667014005670 HIGH motif; other site 667014005671 dimer interface [polypeptide binding]; other site 667014005672 KMSKS motif; other site 667014005673 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 667014005674 RNA binding surface [nucleotide binding]; other site 667014005675 RmuC family; Region: RmuC; pfam02646 667014005676 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 667014005677 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 667014005678 PYR/PP interface [polypeptide binding]; other site 667014005679 dimer interface [polypeptide binding]; other site 667014005680 TPP binding site [chemical binding]; other site 667014005681 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 667014005682 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 667014005683 TPP-binding site [chemical binding]; other site 667014005684 dimer interface [polypeptide binding]; other site 667014005685 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 667014005686 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 667014005687 putative valine binding site [chemical binding]; other site 667014005688 dimer interface [polypeptide binding]; other site 667014005689 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 667014005690 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 667014005691 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; cl02930 667014005692 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 667014005693 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014005694 motif II; other site 667014005695 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 667014005696 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 667014005697 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 667014005698 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 667014005699 shikimate binding site; other site 667014005700 NAD(P) binding site [chemical binding]; other site 667014005701 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 667014005702 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form 5-enolpyruvylshkimate-3-...; Region: EPSP_synthase; cd01556 667014005703 hinge; other site 667014005704 active site 667014005705 shikimate kinase; Reviewed; Region: aroK; PRK00131 667014005706 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the...; Region: SK; cd00464 667014005707 ADP binding site [chemical binding]; other site 667014005708 magnesium binding site [ion binding]; other site 667014005709 putative shikimate binding site; other site 667014005710 PRTRC system protein D; Region: PRTRC_D; TIGR03739 667014005711 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 667014005712 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide...; Region: DsbA_DsbC_DsbG; cd03020 667014005713 dimerization domain [polypeptide binding]; other site 667014005714 dimer interface [polypeptide binding]; other site 667014005715 catalytic residues [active] 667014005716 TraL protein; Region: TraL; cl06278 667014005717 TraE protein; Region: TraE; cl05060 667014005718 TraK protein; Region: TraK; pfam06586 667014005719 Poly A polymerase head domain; Region: PolyA_pol; cl14657 667014005720 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 667014005721 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 667014005722 Peptidase S26; Region: Peptidase_S26; pfam10502 667014005723 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88)...; Region: Peptidase_S24_S26; cl10465 667014005724 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 667014005725 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 667014005726 Conjugative relaxosome accessory transposon protein; Region: TraH; cl05580 667014005727 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 667014005728 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein...; Region: CSP_CDS; cd04458 667014005729 DNA-binding site [nucleotide binding]; DNA binding site 667014005730 RNA-binding motif; other site 667014005731 Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601 667014005732 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 667014005733 dimer interface [polypeptide binding]; other site 667014005734 ssDNA binding site [nucleotide binding]; other site 667014005735 tetramer (dimer of dimers) interface [polypeptide binding]; other site 667014005736 TraU protein; Region: TraU; cl06067 667014005737 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; cl09883 667014005738 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 667014005739 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14877 667014005740 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 667014005741 YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831 667014005742 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 667014005743 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 667014005744 Uncharacterized conserved protein containing a coiled-coil domain [Function unknown]; Region: COG5493 667014005745 Protein of unknown function (DUF736); Region: DUF736; cl02303 667014005746 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868 667014005747 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 667014005748 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014005749 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl14888 667014005750 AAA-like domain; Region: AAA_10; pfam12846 667014005751 FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 667014005752 putative active site [active] 667014005753 Domain of unknown function (DUF955); Region: DUF955; cl01076 667014005754 LabA_like proteins. A well conserved group of bacterial proteins with no defined function. LabA, a member from Synechococcus elongatus PCC 7942, has been shown to play a role in cyanobacterial circadian timing. It is required for negative feedback...; Region: LabA_like; cd06167 667014005755 putative metal binding site [ion binding]; other site 667014005756 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 667014005757 non-specific DNA binding site [nucleotide binding]; other site 667014005758 salt bridge; other site 667014005759 sequence-specific DNA binding site [nucleotide binding]; other site 667014005760 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 667014005761 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 667014005762 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 667014005763 DNA binding site [nucleotide binding] 667014005764 Int/Topo IB signature motif; other site 667014005765 active site 667014005766 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 667014005767 Cation transport protein; Region: TrkH; cl10514 667014005768 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 667014005769 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005770 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014005771 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005772 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014005773 E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent oxidation of L-histidinol to L-...; Region: Histidinol_dh; cd06572 667014005774 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 667014005775 NAD binding site [chemical binding]; other site 667014005776 dimerization interface [polypeptide binding]; other site 667014005777 product binding site; other site 667014005778 substrate binding site [chemical binding]; other site 667014005779 zinc binding site [ion binding]; other site 667014005780 catalytic residues [active] 667014005781 Uncharacterised protein family UPF0047; Region: UPF0047; cl00439 667014005782 Fumarase C-terminus; Region: Fumerase_C; cl00795 667014005783 GTP-binding protein Der; Reviewed; Region: PRK00093 667014005784 EngA1 subfamily. This CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA1; cd01894 667014005785 G1 box; other site 667014005786 GTP/Mg2+ binding site [chemical binding]; other site 667014005787 Switch I region; other site 667014005788 G2 box; other site 667014005789 Switch II region; other site 667014005790 G3 box; other site 667014005791 G4 box; other site 667014005792 G5 box; other site 667014005793 EngA2 subfamily. This CD represents the second GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that...; Region: EngA2; cd01895 667014005794 G1 box; other site 667014005795 GTP/Mg2+ binding site [chemical binding]; other site 667014005796 Switch I region; other site 667014005797 G2 box; other site 667014005798 G3 box; other site 667014005799 Switch II region; other site 667014005800 G4 box; other site 667014005801 G5 box; other site 667014005802 adenylosuccinate synthetase; Provisional; Region: PRK01117 667014005803 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the r-...; Region: AdSS; cd03108 667014005804 GDP-binding site [chemical binding]; other site 667014005805 ACT binding site; other site 667014005806 IMP binding site; other site 667014005807 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 667014005808 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 667014005809 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; cl03087 667014005810 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; cl08365 667014005811 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 667014005812 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl00513 667014005813 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase...; Region: biotinyl_domain; cd06850 667014005814 carboxyltransferase (CT) interaction site; other site 667014005815 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2...; Region: Biotinyl_lipoyl_domains; cl11404 667014005816 lipoyl-biotinyl attachment site [posttranslational modification]; other site 667014005817 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014005818 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 667014005819 Gram-negative bacterial tonB protein; Region: TonB; cl10048 667014005820 Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537 667014005821 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 667014005822 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014005823 cobaltochelatase subunit; Region: Cob-chelat-sub; TIGR02442 667014005824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014005825 Walker A motif; other site 667014005826 ATP binding site [chemical binding]; other site 667014005827 Walker B motif; other site 667014005828 arginine finger; other site 667014005829 Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase...; Region: vWA_Magnesium_chelatase; cd01451 667014005830 metal ion-dependent adhesion site (MIDAS); other site 667014005831 FOG: WD40 repeat [General function prediction only]; Region: COG2319 667014005832 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues...; Region: WD40; cl02567 667014005833 Cobalt transport protein; Region: CbiQ; cl00463 667014005834 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 667014005835 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 667014005836 Walker A/P-loop; other site 667014005837 ATP binding site [chemical binding]; other site 667014005838 Q-loop/lid; other site 667014005839 ABC transporter signature motif; other site 667014005840 Walker B; other site 667014005841 D-loop; other site 667014005842 H-loop/switch region; other site 667014005843 Domain I of the ABC component of a cobalt transport family found in bacteria, archaea, and eukaryota. The transition metal cobalt is an essential component of many enzymes and must be transported into cells in appropriate amounts when needed. This...; Region: ABC_cobalt_CbiO_domain1; cd03225 667014005844 Walker A/P-loop; other site 667014005845 ATP binding site [chemical binding]; other site 667014005846 Q-loop/lid; other site 667014005847 ABC transporter signature motif; other site 667014005848 Walker B; other site 667014005849 D-loop; other site 667014005850 H-loop/switch region; other site 667014005851 Adenosylcobinamide amidohydrolase; Region: CbiZ; cl00808 667014005852 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 667014005853 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 667014005854 N-terminal plug; other site 667014005855 ligand-binding site [chemical binding]; other site 667014005856 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 667014005857 Hydrogenase formation hypA family; Region: HypD; cl12072 667014005858 Protein of unknown function DUF72; Region: DUF72; cl00777 667014005859 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1689 667014005860 Ribosomal protein S20; Region: Ribosomal_S20p; cl00384 667014005861 2,3-bisphosphoglycerate-independent phosphoglycerate mutase, archaeal form; Region: apgM; TIGR00306 667014005862 Sulfatase; Region: Sulfatase; cl10460 667014005863 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH...; Region: alkPPc; cl12039 667014005864 active site 667014005865 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 667014005866 active site 667014005867 nucleotide binding site [chemical binding]; other site 667014005868 HIGH motif; other site 667014005869 KMSKS motif; other site 667014005870 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 667014005871 substrate binding site [chemical binding]; other site 667014005872 multimerization interface [polypeptide binding]; other site 667014005873 ATP binding site [chemical binding]; other site 667014005874 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5- (beta-...; Region: TMP_TenI; cd00564 667014005875 thiamine phosphate binding site [chemical binding]; other site 667014005876 active site 667014005877 pyrophosphate binding site [ion binding]; other site 667014005878 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl00088 667014005879 acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717 667014005880 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014005881 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 667014005882 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl00357 667014005883 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 667014005884 Histone deacetylase domain; Region: Hist_deacetyl; cl02986 667014005885 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 667014005886 substrate binding site [chemical binding]; other site 667014005887 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl09110 667014005888 DctM-like transporters; Region: DctM; pfam06808 667014005889 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 667014005890 succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional; Region: PRK06259 667014005891 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014005892 Cysteine-rich domain; Region: CCG; pfam02754 667014005893 Cysteine-rich domain; Region: CCG; pfam02754 667014005894 FAD binding domain; Region: FAD_binding_4; pfam01565 667014005895 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 667014005896 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl00710 667014005897 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 667014005898 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 667014005899 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 667014005900 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 667014005901 Rubredoxin; Region: Rubredoxin; pfam00301 667014005902 iron binding site [ion binding]; other site 667014005903 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 667014005904 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 667014005905 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 667014005906 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli...; Region: DnaE_OBF; cd04485 667014005907 generic binding surface I; other site 667014005908 generic binding surface II; other site 667014005909 Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313 667014005910 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl15259 667014005911 diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166 667014005912 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 667014005913 active site 667014005914 metal binding site [ion binding]; metal-binding site 667014005915 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 667014005916 N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination of chromosomal replication, and stable plasmid...; Region: INT_XerDC; cd00798 667014005917 Int/Topo IB signature motif; other site 667014005918 active site 667014005919 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl09108 667014005920 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 667014005921 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 667014005922 active site 667014005923 NTP binding site [chemical binding]; other site 667014005924 metal binding triad [ion binding]; metal-binding site 667014005925 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 667014005926 active site 667014005927 putative substrate binding region [chemical binding]; other site 667014005928 DNA topoisomerase I; Validated; Region: PRK07219 667014005929 Dissimilatory sulfite reductase (desulfoviridin), alpha and beta subunits [Energy production and conversion]; Region: DsrA; COG2221 667014005930 4Fe-4S binding domain; Region: Fer4; cl02805 667014005931 MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149 667014005932 4Fe-4S binding domain; Region: Fer4; cl02805 667014005933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 667014005934 Uncharacterized conserved protein [Function unknown]; Region: COG1543 667014005935 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 667014005936 Thiamine biosynthesis ATP pyrophosphatase [Coenzyme metabolism]; Region: ThiI; COG0301 667014005937 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 667014005938 Ligand Binding Site [chemical binding]; other site 667014005939 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 667014005940 putative active site pocket [active] 667014005941 dimerization interface [polypeptide binding]; other site 667014005942 putative catalytic residue [active] 667014005943 Mechanosensitive ion channel; Region: MS_channel; pfam00924 667014005944 Transposase IS200 like; Region: Y1_Tnp; cl00848 667014005945 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 667014005946 putative active site [active] 667014005947 catalytic triad [active] 667014005948 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 667014005949 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 667014005950 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 667014005951 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 667014005952 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 667014005953 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 667014005954 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 667014005955 metal binding site [ion binding]; metal-binding site 667014005956 dimer interface [polypeptide binding]; other site 667014005957 desulfoferrodoxin; Region: dfx_rbo; TIGR00320 667014005958 Desulforedoxin (DSRD) domain; a small non-heme iron domain present in the desulforedoxin (rubredoxin oxidoreductase) and desulfoferrodoxin proteins of some archeael and bacterial methanogens and sulfate/sulfur reducers. Desulforedoxin is a small...; Region: DSRD; cd00974 667014005959 non-heme iron binding site [ion binding]; other site 667014005960 dimer interface [polypeptide binding]; other site 667014005961 Superoxide reductase-like (SORL) domain, class I; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin. Superoxide reductase-like proteins scavenge superoxide anion...; Region: SORL_Dfx_classI; cd03171 667014005962 non-heme iron binding site [ion binding]; other site 667014005963 dimer interface [polypeptide binding]; other site 667014005964 metallo-beta-lactamase/flavodoxin domain-containing protein; Provisional; Region: PRK11921 667014005965 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014005966 NADPH-dependent FMN reductase; Region: FMN_red; cl00438 667014005967 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 667014005968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014005969 FeS/SAM binding site; other site 667014005970 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 667014005971 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 667014005972 UPF0278 family; Region: UPF0278; cl00637 667014005973 Cache domain; Region: Cache_2; cl07034 667014005974 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 667014005975 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014005976 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 667014005977 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014005978 active site 667014005979 phosphorylation site [posttranslational modification] 667014005980 intermolecular recognition site; other site 667014005981 dimerization interface [polypeptide binding]; other site 667014005982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014005983 Walker A motif; other site 667014005984 ATP binding site [chemical binding]; other site 667014005985 Walker B motif; other site 667014005986 arginine finger; other site 667014005987 Bacterial regulatory protein, Fis family; Region: HTH_8; cl01091 667014005988 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014005989 dimer interface [polypeptide binding]; other site 667014005990 phosphorylation site [posttranslational modification] 667014005991 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014005992 ATP binding site [chemical binding]; other site 667014005993 Mg2+ binding site [ion binding]; other site 667014005994 G-X-G motif; other site 667014005995 Response regulator receiver domain; Region: Response_reg; pfam00072 667014005996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014005997 active site 667014005998 phosphorylation site [posttranslational modification] 667014005999 intermolecular recognition site; other site 667014006000 dimerization interface [polypeptide binding]; other site 667014006001 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 667014006002 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; cl01586 667014006003 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; cl09826 667014006004 Predicted permeases [General function prediction only]; Region: COG0730; cl00498 667014006005 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 667014006006 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014006007 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014006008 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014006009 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 667014006010 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432 667014006011 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 667014006012 sulfite reductase, subunit A; Region: sulfite_red_A; TIGR02910 667014006013 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 667014006014 Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221 667014006015 FAD binding pocket [chemical binding]; other site 667014006016 FAD binding motif [chemical binding]; other site 667014006017 phosphate binding motif [ion binding]; other site 667014006018 beta-alpha-beta structure motif; other site 667014006019 NAD binding pocket [chemical binding]; other site 667014006020 Iron coordination center [ion binding]; other site 667014006021 Hemerythrin (Hr) is a non-heme diiron oxygen transport protein found in four marine invertebrate phyla including priapulida, brachiopoda, sipunculida, and annelida, as well as in protozoa. Myohemerythrin (Mhr), a hemerythrin homolog, is found in the...; Region: Hemerythrin; cl11605 667014006022 hemerythrin-like metal-binding domain; Region: hemeryth_dom; TIGR02481 667014006023 octamerization interface [polypeptide binding]; other site 667014006024 diferric-oxygen binding site [ion binding]; other site 667014006025 Rhomboid family; Region: Rhomboid; cl11446 667014006026 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 667014006027 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation...; Region: AlaRS_core; cd00673 667014006028 motif 1; other site 667014006029 active site 667014006030 motif 2; other site 667014006031 motif 3; other site 667014006032 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 667014006033 DHHA1 domain; Region: DHHA1; pfam02272 667014006034 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 667014006035 active site 667014006036 metal binding site [ion binding]; metal-binding site 667014006037 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 667014006038 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 667014006039 active site 667014006040 metal binding site [ion binding]; metal-binding site 667014006041 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 667014006042 Uncharacterized conserved protein [Function unknown]; Region: COG3391 667014006043 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl01255 667014006044 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 667014006045 putative trimer interface [polypeptide binding]; other site 667014006046 putative CoA binding site [chemical binding]; other site 667014006047 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 667014006048 The Mj1267/LivG ABC transporter subfamily is involved in the transport of the hydrophobic amino acids leucine, isoleucine and valine. MJ1267 is a branched-chain amino acid transporter with 29% similarity to both the LivF and LivG components of the E...; Region: ABC_Mj1267_LivG_branched; cd03219 667014006049 Walker A/P-loop; other site 667014006050 ATP binding site [chemical binding]; other site 667014006051 Q-loop/lid; other site 667014006052 ABC transporter signature motif; other site 667014006053 Walker B; other site 667014006054 D-loop; other site 667014006055 H-loop/switch region; other site 667014006056 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 667014006057 LivF (TM1139) is part of the LIV-I bacterial ABC-type two-component transport system that imports neutral, branched-chain amino acids. The E. coli branched-chain amino acid transporter comprises a heterodimer of ABC transporters (LivF and LivG), a...; Region: ABC_TM1139_LivF_branched; cd03224 667014006058 Walker A/P-loop; other site 667014006059 ATP binding site [chemical binding]; other site 667014006060 Q-loop/lid; other site 667014006061 ABC transporter signature motif; other site 667014006062 Walker B; other site 667014006063 D-loop; other site 667014006064 H-loop/switch region; other site 667014006065 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 667014006066 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 667014006067 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 667014006068 active site 667014006069 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most...; Region: PDZ_metalloprotease; cd00989 667014006070 protein binding site [polypeptide binding]; other site 667014006071 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 667014006072 putative substrate binding region [chemical binding]; other site 667014006073 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 667014006074 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 667014006075 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 667014006076 Cytidylyltransferase family; Region: CTP_transf_1; cl00347 667014006077 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 667014006078 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 667014006079 catalytic residue [active] 667014006080 putative FPP diphosphate binding site; other site 667014006081 putative FPP binding hydrophobic cleft; other site 667014006082 dimer interface [polypeptide binding]; other site 667014006083 putative IPP diphosphate binding site; other site 667014006084 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are 'recycled' and ready for another round of...; Region: RRF; cd00520 667014006085 hinge region; other site 667014006086 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control...; Region: AAK_UMPK-PyrH-Ec; cd04254 667014006087 putative nucleotide binding site [chemical binding]; other site 667014006088 uridine monophosphate binding site [chemical binding]; other site 667014006089 homohexameric interface [polypeptide binding]; other site 667014006090 elongation factor Ts; Reviewed; Region: tsf; PRK12332 667014006091 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 667014006092 Elongation factor TS; Region: EF_TS; pfam00889 667014006093 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 667014006094 rRNA interaction site [nucleotide binding]; other site 667014006095 S8 interaction site; other site 667014006096 putative laminin-1 binding site; other site 667014006097 flagellar hook protein FlgE; Validated; Region: flgE; PRK08425 667014006098 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 667014006099 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 667014006100 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 667014006101 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 667014006102 Flagellar hook capping protein; Region: FlgD; cl04347 667014006103 Flagellar hook-length control protein FliK; Region: Flg_hook; cl15269 667014006104 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 667014006105 Clp amino terminal domain; Region: Clp_N; pfam02861 667014006106 Clp amino terminal domain; Region: Clp_N; pfam02861 667014006107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014006108 Walker A motif; other site 667014006109 ATP binding site [chemical binding]; other site 667014006110 Walker B motif; other site 667014006111 arginine finger; other site 667014006112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes...; Region: AAA; cd00009 667014006113 Walker A motif; other site 667014006114 ATP binding site [chemical binding]; other site 667014006115 Walker B motif; other site 667014006116 arginine finger; other site 667014006117 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; cl11083 667014006118 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 667014006119 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014006120 Ras-like GTPase superfamily. The Ras-like superfamily of small GTPases consists of several families with an extremely high degree of structural and functional similarity. The Ras superfamily is divided into at least four families in eukaryotes: the Ras...; Region: Ras_like_GTPase; cl10444 667014006121 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 667014006122 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014006123 S-adenosylmethionine binding site [chemical binding]; other site 667014006124 Protein of unknown function (DUF452); Region: DUF452; cl01062 667014006125 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187 667014006126 Predicted kinase [General function prediction only]; Region: COG0645 667014006127 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 667014006128 ATP-binding site [chemical binding]; other site 667014006129 Gluconate-6-phosphate binding site [chemical binding]; other site 667014006130 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 667014006131 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 667014006132 active site 667014006133 HIGH motif; other site 667014006134 dimer interface [polypeptide binding]; other site 667014006135 KMSKS motif; other site 667014006136 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 667014006137 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others...; Region: HAD_like; cd01427 667014006138 motif II; other site 667014006139 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 667014006140 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 667014006141 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 667014006142 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 667014006143 Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414 667014006144 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; cl08354 667014006145 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 667014006146 SelB subfamily. SelB is an elongation factor needed for the co-translational incorporation of selenocysteine. Selenocysteine is coded by a UGA stop codon in combination with a specific downstream mRNA hairpin. In bacteria, the C-terminal part of...; Region: SelB; cd04171 667014006147 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 667014006148 G1 box; other site 667014006149 putative GEF interaction site [polypeptide binding]; other site 667014006150 GTP/Mg2+ binding site [chemical binding]; other site 667014006151 Switch I region; other site 667014006152 G2 box; other site 667014006153 G3 box; other site 667014006154 Switch II region; other site 667014006155 G4 box; other site 667014006156 G5 box; other site 667014006157 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires...; Region: selB_II; cd03696 667014006158 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 667014006159 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 667014006160 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 667014006161 Peptidase family M54; Region: Peptidase_M54; cl00835 667014006162 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cl12011 667014006163 ScpA/B protein; Region: ScpA_ScpB; cl00598 667014006164 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 667014006165 homodimer interaction site [polypeptide binding]; other site 667014006166 cofactor binding site; other site 667014006167 Predicted SPOUT methyltransferase; Region: SPOUT_MTase; cl00679 667014006168 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 667014006169 active site 667014006170 PilZ domain; Region: PilZ; cl01260 667014006171 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 667014006172 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 667014006173 active site 667014006174 HIGH motif; other site 667014006175 KMSKS motif; other site 667014006176 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 667014006177 tRNA binding surface [nucleotide binding]; other site 667014006178 anticodon binding site; other site 667014006179 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 667014006180 dimer interface [polypeptide binding]; other site 667014006181 putative tRNA-binding site [nucleotide binding]; other site 667014006182 PSP1 C-terminal conserved region; Region: PSP1; cl00770 667014006183 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are monomeric...; Region: PRAI; cd00405 667014006184 active site 667014006185 Type II/IV secretion system protein; Region: GSPII_E; pfam00437 667014006186 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 667014006187 Walker A motif; other site 667014006188 ATP binding site [chemical binding]; other site 667014006189 Walker B motif; other site 667014006190 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 667014006191 Bacterial type II secretion system protein G; Region: GSPII_G; pfam08334 667014006192 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 667014006193 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 667014006194 Bacterial type II secretion system protein F domain; Region: GSPII_F; cl00906 667014006195 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 667014006196 General secretion pathway protein K; Region: GspK; pfam03934 667014006197 general secretion pathway protein D; Region: type_II_gspD; TIGR02517 667014006198 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 667014006199 Bacterial type II and III secretion system protein; Region: Secretin; cl02829 667014006200 seryl-tRNA synthetase; Provisional; Region: PRK05431 667014006201 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 667014006202 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 667014006203 dimer interface [polypeptide binding]; other site 667014006204 active site 667014006205 motif 1; other site 667014006206 motif 2; other site 667014006207 motif 3; other site 667014006208 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 667014006209 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 667014006210 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 667014006211 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 667014006212 radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960 667014006213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cd01335 667014006214 FeS/SAM binding site; other site 667014006215 radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936 667014006216 Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; cl02090 667014006217 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 667014006218 active site 667014006219 tetramer interface [polypeptide binding]; other site 667014006220 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 667014006221 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014006222 Walker A motif; other site 667014006223 ATP binding site [chemical binding]; other site 667014006224 Walker B motif; other site 667014006225 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 667014006226 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 667014006227 Walker A motif; other site 667014006228 ATP binding site [chemical binding]; other site 667014006229 Walker B motif; other site 667014006230 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 667014006231 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014006232 Walker A/P-loop; other site 667014006233 ATP binding site [chemical binding]; other site 667014006234 Q-loop/lid; other site 667014006235 ABC transporter signature motif; other site 667014006236 Walker B; other site 667014006237 D-loop; other site 667014006238 H-loop/switch region; other site 667014006239 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 667014006240 FtsX-like permease family; Region: FtsX; pfam02687 667014006241 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 667014006242 Peptidase family M23; Region: Peptidase_M23; pfam01551 667014006243 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 667014006244 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 667014006245 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 667014006246 protein binding site [polypeptide binding]; other site 667014006247 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 667014006248 Catalytic dyad [active] 667014006249 Divergent polysaccharide deacetylase; Region: Polysacc_deac_2; cl04721 667014006250 histidinol-phosphate aminotransferase; Region: hisC; TIGR01141 667014006251 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 667014006252 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014006253 homodimer interface [polypeptide binding]; other site 667014006254 catalytic residue [active] 667014006255 cytidylate kinase; Provisional; Region: cmk; PRK00023 667014006256 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 667014006257 CMP-binding site; other site 667014006258 The sites determining sugar specificity; other site 667014006259 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 667014006260 Ligand binding site [chemical binding]; other site 667014006261 Putative Catalytic site [active] 667014006262 DXD motif; other site 667014006263 Predicted integral membrane protein [Function unknown]; Region: COG0392 667014006264 Uncharacterised protein family (UPF0104); Region: UPF0104; cl04219 667014006265 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 667014006266 EamA-like transporter family; Region: EamA; cl01037 667014006267 EamA-like transporter family; Region: EamA; cl01037 667014006268 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 667014006269 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 667014006270 putative active site [active] 667014006271 substrate binding site [chemical binding]; other site 667014006272 putative cosubstrate binding site; other site 667014006273 catalytic site [active] 667014006274 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 667014006275 substrate binding site [chemical binding]; other site 667014006276 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 667014006277 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014006278 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014006279 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 667014006280 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 667014006281 DnaJ central domain; Region: DnaJ_CXXCXGXG; cl14908 667014006282 The excision repair protein UvrA domain I; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_I; cd03270 667014006283 The excision repair protein UvrA domain II; Nucleotide excision repair in eubacteria is a process that repairs DNA damage by the removal of a 12-13-mer oligonucleotide containing the lesion. Recognition and cleavage of the damaged DNA is a multistep...; Region: ABC_UvrA_II; cd03271 667014006284 Sulfatase; Region: Sulfatase; cl10460 667014006285 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 667014006286 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cl00427 667014006287 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits...; Region: TM_PBP2; cd06261 667014006288 dimer interface [polypeptide binding]; other site 667014006289 conserved gate region; other site 667014006290 putative PBP binding loops; other site 667014006291 ABC-ATPase subunit interface; other site 667014006292 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 667014006293 P-loop containing Nucleoside Triphosphate Hydrolases; Region: P-loop NTPase; cl09099 667014006294 Walker A/P-loop; other site 667014006295 ATP binding site [chemical binding]; other site 667014006296 Q-loop/lid; other site 667014006297 ABC transporter signature motif; other site 667014006298 Walker B; other site 667014006299 D-loop; other site 667014006300 H-loop/switch region; other site 667014006301 TOBE domain; Region: TOBE_2; cl01440 667014006302 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 667014006303 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014006304 Uncharacterized conserved protein [Function unknown]; Region: COG1912 667014006305 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 667014006306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014006307 S-adenosylmethionine binding site [chemical binding]; other site 667014006308 Protein of unknown function (DUF721); Region: DUF721; cl02324 667014006309 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 667014006310 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 667014006311 active site 667014006312 substrate binding site [chemical binding]; other site 667014006313 metal binding site [ion binding]; metal-binding site 667014006314 Signal transduction histidine kinase, nitrate/nitrite-specific [Signal transduction mechanisms]; Region: NarQ; COG3850 667014006315 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 667014006316 dimerization interface [polypeptide binding]; other site 667014006317 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 667014006318 Taxis toward Aspartate and Related amino acids and Homologs (TarH). The Tar chemoreceptor of Escherichia coli mediates attractant responses to aspartate, maltose, and phenol, repellent responses to Ni2+ and Co2+, and thermoresponses. These...; Region: TarH; cl00144 667014006319 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 667014006320 DHH family; Region: DHH; pfam01368 667014006321 DHHA1 domain; Region: DHHA1; pfam02272 667014006322 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and higher-...; Region: HU_IHF; cl00257 667014006323 enolase; Provisional; Region: eno; PRK00077 667014006324 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 667014006325 dimer interface [polypeptide binding]; other site 667014006326 metal binding site [ion binding]; metal-binding site 667014006327 substrate binding pocket [chemical binding]; other site 667014006328 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them...; Region: YcaC_related; cd01012 667014006329 Isochorismatase family; Region: Isochorismatase; pfam00857 667014006330 catalytic triad [active] 667014006331 dimer interface [polypeptide binding]; other site 667014006332 conserved cis-peptide bond; other site 667014006333 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 667014006334 ATP cone domain; Region: ATP-cone; pfam03477 667014006335 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They...; Region: rubredoxin; cd00730 667014006336 Rubredoxin; Region: Rubredoxin; pfam00301 667014006337 iron binding site [ion binding]; other site 667014006338 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014006339 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 667014006340 putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814 667014006341 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 667014006342 catalytic loop [active] 667014006343 iron binding site [ion binding]; other site 667014006344 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014006345 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014006346 4Fe-4S binding domain; Region: Fer4; cl02805 667014006347 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H)...; Region: MopB_Formate-Dh-H; cd02753 667014006348 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 667014006349 [4Fe-4S] binding site [ion binding]; other site 667014006350 molybdopterin cofactor binding site; other site 667014006351 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 667014006352 molybdopterin cofactor binding site; other site 667014006353 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 667014006354 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit; Region: CO_dh; cl00815 667014006355 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 667014006356 substrate binding pocket [chemical binding]; other site 667014006357 dimer interface [polypeptide binding]; other site 667014006358 inhibitor binding site; inhibition site 667014006359 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl08495 667014006360 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 667014006361 active site 667014006362 NTP binding site [chemical binding]; other site 667014006363 metal binding triad [ion binding]; metal-binding site 667014006364 antibiotic binding site [chemical binding]; other site 667014006365 acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165 667014006366 Putative Fe-S cluster; Region: FeS; pfam04060 667014006367 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 667014006368 bifunctional acetyl-CoA decarbonylase/synthase complex subunit alpha/beta; Reviewed; Region: PRK09529 667014006369 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014006370 metal cluster binding site [ion binding]; other site 667014006371 CO dehydrogenase/acetyl-CoA synthase complex beta subunit; Region: CdhC; cl11685 667014006372 Methylenetetrahydrofolate reductase; Region: MTHFR; pfam02219 667014006373 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine...; Region: MTHFR; cd00537 667014006374 FAD binding site [chemical binding]; other site 667014006375 acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452 667014006376 Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225 667014006377 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 667014006378 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014006379 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014006380 2-ketoisovalerate ferredoxin oxidoreductase subunit delta; Reviewed; Region: vorD; PRK09623 667014006381 Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831 667014006382 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014006383 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014006384 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014006385 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014006386 Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148 667014006387 4Fe-4S binding domain; Region: Fer4; cl02805 667014006388 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014006389 Prismane/CO dehydrogenase family; Region: Prismane; pfam03063 667014006390 ACS interaction site; other site 667014006391 CODH interaction site; other site 667014006392 metal cluster binding site [ion binding]; other site 667014006393 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 667014006394 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 667014006395 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 667014006396 homodimer interface [polypeptide binding]; other site 667014006397 NADP binding site [chemical binding]; other site 667014006398 substrate binding site [chemical binding]; other site 667014006399 Formate--tetrahydrofolate ligase; Region: FTHFS; pfam01268 667014006400 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 667014006401 Potassium binding sites [ion binding]; other site 667014006402 Cesium cation binding sites [ion binding]; other site 667014006403 PilZ domain; Region: PilZ; cl01260 667014006404 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 667014006405 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014006406 S-adenosylmethionine binding site [chemical binding]; other site 667014006407 glutamine synthetase, type I; Region: GlnA; TIGR00653 667014006408 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 667014006409 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 667014006410 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 667014006411 [Protein-PII] uridylyltransferase; Region: UTase_glnD; TIGR01693 667014006412 metal binding triad; other site 667014006413 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 667014006414 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014006415 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 667014006416 ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD; Region: ACT_UUR-ACR-like; cd04873 667014006417 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl00412 667014006418 Flagellin N-methylase; Region: FliB; cl00497 667014006419 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 667014006420 Ligand Binding Site [chemical binding]; other site 667014006421 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 667014006422 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 667014006423 oligomerization interface [polypeptide binding]; other site 667014006424 active site 667014006425 NAD+ binding site [chemical binding]; other site 667014006426 S-adenosylmethionine synthetase; Validated; Region: PRK05250 667014006427 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 667014006428 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 667014006429 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 667014006430 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: COG2248 667014006431 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 667014006432 UGMP family protein; Validated; Region: PRK09604 667014006433 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl14000 667014006434 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014006435 S-adenosylmethionine binding site [chemical binding]; other site 667014006436 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 667014006437 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 667014006438 catalytic triad [active] 667014006439 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 667014006440 NeuB family; Region: NeuB; cl00496 667014006441 MarC family integral membrane protein; Region: MarC; cl00919 667014006442 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of...; Region: ThiF_MoeB_HesA_family; cd00757 667014006443 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 667014006444 ATP binding site [chemical binding]; other site 667014006445 substrate interface [chemical binding]; other site 667014006446 Ubiquitin-like proteins; Region: UBQ; cl00155 667014006447 charged pocket; other site 667014006448 hydrophobic patch; other site 667014006449 aspartate aminotransferase; Provisional; Region: PRK06836 667014006450 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 667014006451 pyridoxal 5'-phosphate binding site [chemical binding]; other site 667014006452 homodimer interface [polypeptide binding]; other site 667014006453 catalytic residue [active] 667014006454 Acyl-protein synthetase, LuxE; Region: LuxE; cl10450 667014006455 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 667014006456 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and...; Region: DUS_like_FMN; cd02801 667014006457 FMN binding site [chemical binding]; other site 667014006458 active site 667014006459 catalytic residues [active] 667014006460 substrate binding site [chemical binding]; other site 667014006461 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl00076 667014006462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 667014006463 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 667014006464 active site 667014006465 metal binding site [ion binding]; metal-binding site 667014006466 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 667014006467 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl09485 667014006468 Protein of unknown function (DUF3365); Region: DUF3365; pfam11845 667014006469 Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The...; Region: HAMP; cd06225 667014006470 dimerization interface [polypeptide binding]; other site 667014006471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-...; Region: HisKA; cd00082 667014006472 dimer interface [polypeptide binding]; other site 667014006473 phosphorylation site [posttranslational modification] 667014006474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 667014006475 ATP binding site [chemical binding]; other site 667014006476 Mg2+ binding site [ion binding]; other site 667014006477 G-X-G motif; other site 667014006478 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 667014006479 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems...; Region: REC; cd00156 667014006480 active site 667014006481 phosphorylation site [posttranslational modification] 667014006482 intermolecular recognition site; other site 667014006483 dimerization interface [polypeptide binding]; other site 667014006484 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase...; Region: trans_reg_C; cd00383 667014006485 DNA binding site [nucleotide binding] 667014006486 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 667014006487 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 667014006488 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 667014006489 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved alpha-; Region: HCP_like; cl14655 667014006490 NapD protein; Region: NapD; cl01163 667014006491 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 667014006492 NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol oxidation via a membrane-anchored...; Region: MopB_Nitrate-R-NapA-like; cd02754 667014006493 [4Fe-4S] binding site [ion binding]; other site 667014006494 molybdopterin cofactor binding site; other site 667014006495 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of...; Region: MopB_CT_Fdh-Nap-like; cd00508 667014006496 molybdopterin cofactor binding site; other site 667014006497 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 667014006498 Ferrous iron transport protein B (FeoB) subfamily. E. coli has an iron(II) transport system, known as feo, which may make an important contribution to the iron supply of the cell under anaerobic conditions. FeoB has been identified as part of this...; Region: FeoB; cd01879 667014006499 G1 box; other site 667014006500 GTP/Mg2+ binding site [chemical binding]; other site 667014006501 Switch I region; other site 667014006502 G2 box; other site 667014006503 G3 box; other site 667014006504 Switch II region; other site 667014006505 G4 box; other site 667014006506 G5 box; other site 667014006507 Nucleoside recognition; Region: Gate; cl00486 667014006508 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 667014006509 Nucleoside recognition; Region: Gate; cl00486 667014006510 Predicted methyltransferases [General function prediction only]; Region: COG1568 667014006511 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy)...; Region: AdoMet_MTases; cd02440 667014006512 nickel responsive regulator; Provisional; Region: PRK04460 667014006513 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 667014006514 Curli production assembly/transport component CsgG; Region: CsgG; cl00639 667014006515 CutA1 divalent ion tolerance protein; Region: CutA1; cl00584 667014006516 Transposase; Region: DEDD_Tnp_IS110; pfam01548 667014006517 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371